Search of human proteins with 4503625

Search of human proteins with 4503625

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503625 coagulation factor X preproprotein [Homo sapiens]
         (488 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503625 coagulation factor X preproprotein [Homo sapiens]         1019   0.0  
gi|4503649 coagulation factor IX preproprotein [Homo sapiens]         395   e-110
gi|10518503 coagulation factor VII isoform b precursor [Homo sap...   358   8e-99
gi|4503645 coagulation factor VII isoform a precursor [Homo sapi...   355   7e-98
gi|4506115 protein C [Homo sapiens]                                   311   9e-85
gi|4506121 protein Z, vitamin K-dependent plasma glycoprotein [H...   191   1e-48
gi|4503635 coagulation factor II preproprotein [Homo sapiens]         174   2e-43
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         152   9e-37
gi|110578663 hypothetical protein LOC203074 [Homo sapiens]            151   1e-36
gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]           150   3e-36
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]           149   4e-36
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           149   4e-36
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           148   1e-35
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]        147   2e-35
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             146   5e-35
gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]       145   6e-35
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   143   4e-34
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   143   4e-34
gi|4506143 neurotrypsin precursor [Homo sapiens]                      143   4e-34
gi|13994276 marapsin [Homo sapiens]                                   142   9e-34
gi|21264363 mannan-binding lectin serine protease 2 isoform 1 pr...   141   1e-33
gi|4506153 prostasin preproprotein [Homo sapiens]                     141   1e-33
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          141   1e-33
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   140   2e-33
gi|11415040 matriptase [Homo sapiens]                                 140   3e-33
gi|66347875 complement component 1, r subcomponent [Homo sapiens]     139   4e-33
gi|4758502 hyaluronan binding protein 2 preproprotein [Homo sapi...   139   6e-33
gi|4503627 coagulation factor XI precursor [Homo sapiens]             139   8e-33
gi|110815798 ovochymase 1 [Homo sapiens]                              138   1e-32
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          137   2e-32

>gi|4503625 coagulation factor X preproprotein [Homo sapiens]
          Length = 488

 Score = 1019 bits (2636), Expect = 0.0
 Identities = 488/488 (100%), Positives = 488/488 (100%)

Query: 1   MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE 60
           MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
Sbjct: 1   MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE 60

Query: 61  TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN 120
           TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
Sbjct: 61  TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN 120

Query: 121 CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR 180
           CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
Sbjct: 121 CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR 180

Query: 181 KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE 240
           KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
Sbjct: 181 KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE 240

Query: 241 CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE 300
           CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
Sbjct: 241 CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE 300

Query: 301 AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI 360
           AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
Sbjct: 301 AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI 360

Query: 361 VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG 420
           VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
Sbjct: 361 VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG 420

Query: 421 GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE 480
           GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
Sbjct: 421 GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE 480

Query: 481 VITSSPLK 488
           VITSSPLK
Sbjct: 481 VITSSPLK 488


>gi|4503649 coagulation factor IX preproprotein [Homo sapiens]
          Length = 461

 Score =  395 bits (1016), Expect = e-110
 Identities = 208/464 (44%), Positives = 284/464 (61%), Gaps = 23/464 (4%)

Query: 9   LLSASLAGLLLLGE-SLFIRREQANNILARVTRANSF-LEEMKKGHLERECMEETCSYEE 66
           L++  L G LL  E ++F+  E AN IL R  R NS  LEE  +G+LERECMEE CS+EE
Sbjct: 14  LITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEE 73

Query: 67  AREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTR 126
           AREVFE++++T EFW +Y DGDQCE++PC N G CKD +  Y C C  GFEGKNCEL   
Sbjct: 74  AREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVT 133

Query: 127 KLCSLDNGDCDQFC-HEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVA 185
             C++ NG C+QFC +   N VVCSC  GY LA+N K+C P  P+PCG+ ++ +     +
Sbjct: 134 --CNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQ----TS 187

Query: 186 QATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGE 245
           + T +    PD       D  +    E   D    N TQ  +  N+ TR+VGG++ K G+
Sbjct: 188 KLTRAETVFPD------VDYVNSTEAETILD----NITQSTQSFNDFTRVVGGEDAKPGQ 237

Query: 246 CPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEV 305
            PWQ +L N + + FCGG+I++E +I+TAAHC+    +  V  G+ N E+ E  E    V
Sbjct: 238 FPWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNV 296

Query: 306 EVVIKHNRFTK--ETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSG 363
             +I H+ +      Y+ DIA+L L  P+     V P C+ ++++  +  +   +G VSG
Sbjct: 297 IRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYT-NIFLKFGSGYVSG 355

Query: 364 FGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPH 423
           +GR   KGR +  L+ L VP VDR +C  S+ F I  NMFCAG+     D+CQGDSGGPH
Sbjct: 356 WGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPH 415

Query: 424 VTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMK 467
           VT  + T F+TGI+SWGE CA KGKYGIYTKV+ ++ WI    K
Sbjct: 416 VTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTK 459


>gi|10518503 coagulation factor VII isoform b precursor [Homo
           sapiens]
          Length = 444

 Score =  358 bits (918), Expect = 8e-99
 Identities = 187/491 (38%), Positives = 276/491 (56%), Gaps = 62/491 (12%)

Query: 1   MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE 60
           + + L L+ L   L G L    ++F+ +E+A+ +L R  RAN+FLEE++ G LEREC EE
Sbjct: 2   VSQALRLLCLLLGLQGCLA---AVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEE 58

Query: 61  TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN 120
            CS+EEARE+F+D+++T  FW  Y DGDQC +SPCQN G CKD L  Y C CL  FEG+N
Sbjct: 59  QCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRN 118

Query: 121 CELFT--RKLCSLDNGDCDQFCHEEQNSV-VCSCARGYTLADNGKACIPTGPYPCGK-QT 176
           CE     + +C  +NG C+Q+C +   +   C C  GY+L  +G +C PT  YPCGK   
Sbjct: 119 CETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPI 178

Query: 177 LERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIV 236
           LE+R  S  Q                                               RIV
Sbjct: 179 LEKRNASKPQG----------------------------------------------RIV 192

Query: 237 GGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRV---GDRNT 293
           GG+ C  GECPWQ LL+    +  CGGT+++  ++++AAHC  + K ++  +   G+ + 
Sbjct: 193 GGKVCPKGECPWQVLLLVNGAQ-LCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDL 251

Query: 294 EQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTL 353
            + +G E    V  VI  + +   T + DIA+LRL  P+    +V P CLPER ++E TL
Sbjct: 252 SEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTL 311

Query: 354 MTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSC-----KLSSSFIITQNMFCAGYD 408
              +  +VSG+G+  ++G  +  L +L VP +    C     K+  S  IT+ MFCAGY 
Sbjct: 312 AFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYS 371

Query: 409 TKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKT 468
              +D+C+GDSGGPH T ++ T+++TGIVSWG+GCA  G +G+YT+V+ +++W+ + M++
Sbjct: 372 DGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRS 431

Query: 469 RGLPKAKSHAP 479
              P     AP
Sbjct: 432 EPRPGVLLRAP 442


>gi|4503645 coagulation factor VII isoform a precursor [Homo
           sapiens]
          Length = 466

 Score =  355 bits (910), Expect = 7e-98
 Identities = 181/468 (38%), Positives = 266/468 (56%), Gaps = 59/468 (12%)

Query: 24  LFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNK 83
           +F+ +E+A+ +L R  RAN+FLEE++ G LEREC EE CS+EEARE+F+D+++T  FW  
Sbjct: 44  VFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWIS 103

Query: 84  YKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFT--RKLCSLDNGDCDQFCH 141
           Y DGDQC +SPCQN G CKD L  Y C CL  FEG+NCE     + +C  +NG C+Q+C 
Sbjct: 104 YSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCS 163

Query: 142 EEQNSV-VCSCARGYTLADNGKACIPTGPYPCGK-QTLERRKRSVAQATSSSGEAPDSIT 199
           +   +   C C  GY+L  +G +C PT  YPCGK   LE+R  S  Q             
Sbjct: 164 DHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQG------------ 211

Query: 200 WKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEG 259
                                             RIVGG+ C  GECPWQ LL+    + 
Sbjct: 212 ----------------------------------RIVGGKVCPKGECPWQVLLLVNGAQ- 236

Query: 260 FCGGTILSEFYILTAAHCLYQAKRFKVRV---GDRNTEQEEGGEAVHEVEVVIKHNRFTK 316
            CGGT+++  ++++AAHC  + K ++  +   G+ +  + +G E    V  VI  + +  
Sbjct: 237 LCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVP 296

Query: 317 ETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTR 376
            T + DIA+LRL  P+    +V P CLPER ++E TL   +  +VSG+G+  ++G  +  
Sbjct: 297 GTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALE 356

Query: 377 LKMLEVPYVDRNSC-----KLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTY 431
           L +L VP +    C     K+  S  IT+ MFCAGY    +D+C+GDSGGPH T ++ T+
Sbjct: 357 LMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTW 416

Query: 432 FVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAP 479
           ++TGIVSWG+GCA  G +G+YT+V+ +++W+ + M++   P     AP
Sbjct: 417 YLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAP 464


>gi|4506115 protein C [Homo sapiens]
          Length = 461

 Score =  311 bits (797), Expect = 9e-85
 Identities = 167/475 (35%), Positives = 259/475 (54%), Gaps = 54/475 (11%)

Query: 22  ESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFW 81
           +S+F   E+A+ +L    RANSFLEE++   LEREC+EE C +EEA+E+F++ D T  FW
Sbjct: 24  DSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFW 83

Query: 82  NKYKDGDQCETSP--------CQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKL-CSLD 132
           +K+ DGDQC   P        C   G C DG+G ++C C  G+EG+ C+     L CSLD
Sbjct: 84  SKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLD 143

Query: 133 NGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGK--QTLERRKRSVAQATSS 190
           NG C  +C EE     CSCA GY L D+   C P   +PCG+  + +E+++  + + T  
Sbjct: 144 NGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTED 203

Query: 191 SGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQA 250
             +              +DP                       R++ G+  + G+ PWQ 
Sbjct: 204 QED-------------QVDP-----------------------RLIDGKMTRRGDSPWQV 227

Query: 251 LLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIK 310
           +L++ + +  CG  ++   ++LTAAHC+ ++K+  VR+G+ +  + E  E   +++ V  
Sbjct: 228 VLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFV 287

Query: 311 HNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTL-MTQKTGIVSGFGRTHE 369
           H  ++K T D DIA+L L  P T    + P CLP+   AE  L    +  +V+G+G    
Sbjct: 288 HPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSS 347

Query: 370 KGRQSTR-----LKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHV 424
           + +++ R     L  +++P V  N C    S ++++NM CAG    ++DAC+GDSGGP V
Sbjct: 348 REKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMV 407

Query: 425 TRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAP 479
             F  T+F+ G+VSWGEGC     YG+YTKV+ +L WI   ++ +  P+ KS AP
Sbjct: 408 ASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQ-KSWAP 461


>gi|4506121 protein Z, vitamin K-dependent plasma glycoprotein [Homo
           sapiens]
          Length = 400

 Score =  191 bits (486), Expect = 1e-48
 Identities = 134/448 (29%), Positives = 198/448 (44%), Gaps = 75/448 (16%)

Query: 23  SLFIRREQANNILARVTRANSFL-EEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFW 81
           S+F+   +AN++L R  RA S+L EE+ +G+LE+EC EE C YEEAREVFE+   T+EFW
Sbjct: 23  SVFLPASKANDVLVRWKRAGSYLLEELFEGNLEKECYEEICVYEEAREVFENEVVTDEFW 82

Query: 82  NKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCH 141
            +YK G  C + PC + G C+D +  YTCTC  G+EG NCEL   +        C  FC 
Sbjct: 83  RRYKGGSPCISQPCLHNGSCQDSIWGYTCTCSPGYEGSNCELAKNECHPERTDGCQHFCL 142

Query: 142 EEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPD--SIT 199
             Q S  CSCA+GY L ++ K C+P     CG  T E+R             APD   + 
Sbjct: 143 PGQESYTCSCAQGYRLGEDHKQCVPHDQCACGVLTSEKR-------------APDLQDLP 189

Query: 200 WKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEG 259
           W+                              LT   G   C                  
Sbjct: 190 WQV----------------------------KLTNSEGKDFC------------------ 203

Query: 260 FCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETY 319
             GG I+ E ++LT A C    +   V+     T Q+     +  V V   H R+  +  
Sbjct: 204 --GGVIIRENFVLTTAKCSLLHRNITVKTYFNRTSQDPLMIKITHVHV---HMRYDADAG 258

Query: 320 DFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKM 379
           + D+++L L+ PI       P C PE+D+AE  L+ +  G++SG+ R       S  L  
Sbjct: 259 ENDLSLLELEWPIQCPGAGLPVCTPEKDFAEHLLIPRTRGLLSGWARNGTDLGNS--LTT 316

Query: 380 LEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTR-FKDTYFVTGIVS 438
             V  V+   C    +  +T   +C     +   A      G  VTR  + ++F+TG++ 
Sbjct: 317 RPVTLVEGEECGQVLNVTVTTRTYC----ERSSVAAMHWMDGSVVTREHRGSWFLTGVLG 372

Query: 439 WGEGCARKGKYGIYTKVTAFLKWIDRSM 466
             +    +    + TKV+ +  W  + M
Sbjct: 373 -SQPVGGQAHMVLVTKVSRYSLWFKQIM 399


>gi|4503635 coagulation factor II preproprotein [Homo sapiens]
          Length = 622

 Score =  174 bits (440), Expect = 2e-43
 Identities = 102/254 (40%), Positives = 144/254 (56%), Gaps = 24/254 (9%)

Query: 234 RIVGGQECKDGECPWQALLINEE-NEGFCGGTILSEFYILTAAHCL--------YQAKRF 284
           RIV G + + G  PWQ +L  +   E  CG +++S+ ++LTAAHCL        +     
Sbjct: 363 RIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDL 422

Query: 285 KVRVGDRN-TEQEEGGEAVHEVEVVIKHNRFT-KETYDFDIAVLRLKTPITFRMNVAPAC 342
            VR+G  + T  E   E +  +E +  H R+  +E  D DIA+++LK P+ F   + P C
Sbjct: 423 LVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVC 482

Query: 343 LPERDWAESTLMTQKTGIVSGFGRTHE-------KGRQSTRLKMLEVPYVDRNSCKLSSS 395
           LP+R+ A S L     G V+G+G   E       KG+ S  L+++ +P V+R  CK S+ 
Sbjct: 483 LPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSV-LQVVNLPIVERPVCKDSTR 541

Query: 396 FIITQNMFCAGY---DTKQEDACQGDSGGPHVTR--FKDTYFVTGIVSWGEGCARKGKYG 450
             IT NMFCAGY   + K+ DAC+GDSGGP V +  F + ++  GIVSWGEGC R GKYG
Sbjct: 542 IRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYG 601

Query: 451 IYTKVTAFLKWIDR 464
            YT V    KWI +
Sbjct: 602 FYTHVFRLKKWIQK 615



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 46/96 (47%), Positives = 62/96 (64%), Gaps = 10/96 (10%)

Query: 18  LLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKT 77
           L+  + +F+  +QA ++L RV RAN+FLEE++KG+LEREC+EETCSYEEA E  E S  T
Sbjct: 21  LVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTAT 80

Query: 78  NEFWNKYKDGDQCETSPCQN-------QGKCKDGLG 106
           + FW KY     CET+           +G C +GLG
Sbjct: 81  DVFWAKY---TACETARTPRDKLAACLEGNCAEGLG 113


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  152 bits (383), Expect = 9e-37
 Identities = 90/243 (37%), Positives = 129/243 (53%), Gaps = 15/243 (6%)

Query: 234 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKR-----FKVRV 288
           RIVGG    D + PWQ  L +      CGGT++   ++LTAAHC +  +      +KV  
Sbjct: 325 RIVGGALASDSKWPWQVSL-HFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYA 383

Query: 289 GDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDW 348
           G  N  Q    EA    E++I  N +T E  D+DIA++RL  P+T   ++ PACLP    
Sbjct: 384 GTSNLHQLP--EAASIAEIIINSN-YTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHG- 439

Query: 349 AESTLMTQKTGIVSGFGRTHEKG-RQSTRLKMLEVPYVDRNSCK--LSSSFIITQNMFCA 405
              T    +T  ++GFG+T E   + S  L+ ++V  +D   C   L     +T  M CA
Sbjct: 440 --QTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCA 497

Query: 406 GYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRS 465
           G      D+CQGDSGGP V    + +++ G+ SWG GC ++ K G+YTKVT  L WI   
Sbjct: 498 GDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSK 557

Query: 466 MKT 468
           M++
Sbjct: 558 MES 560


>gi|110578663 hypothetical protein LOC203074 [Homo sapiens]
          Length = 352

 Score =  151 bits (381), Expect = 1e-36
 Identities = 95/285 (33%), Positives = 145/285 (50%), Gaps = 10/285 (3%)

Query: 193 EAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALL 252
           EA  +I  +   A    P   P  + +        G    +RI GG E + GE PWQ + 
Sbjct: 26  EAGVAILGRARGAHRPQPPHPPSPVSECGDRSIFEGRTRYSRITGGMEAEVGEFPWQ-VS 84

Query: 253 INEENEGFCGGTILSEFYILTAAHCLYQAKRF--KVRVGDRNTEQEEGGEAVHEVEVVIK 310
           I   +E FCGG+IL++++ILTAAHCLY  + F  ++ V     +       + EV  +I 
Sbjct: 85  IQARSEPFCGGSILNKWWILTAAHCLYSEELFPEELSVVLGTNDLTSPSMEIKEVASIIL 144

Query: 311 HNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEK 370
           H  F +   D DIA+L L +PI       P CLP     +    T +   V+G+G+T+  
Sbjct: 145 HKDFKRANMDNDIALLLLASPIKLDDLKVPICLP----TQPGPATWRECWVAGWGQTNAA 200

Query: 371 GRQSTRLKMLEVPYVDRNSCKLSSSF-IITQNMFCAGYDTKQEDACQGDSGGPHVTRFK- 428
            + S +  +++ P V  +  + S  F  +T+NM CAGY  +  DAC+GDSGGP V   + 
Sbjct: 201 DKNSVKTDLMKAPMVIMDWEECSKMFPKLTKNMLCAGYKNESYDACKGDSGGPLVCTPEP 260

Query: 429 -DTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLP 472
            + ++  GI+SWG+ C  K   GIYT +  +  WI++  +  G P
Sbjct: 261 GEKWYQVGIISWGKSCGEKNTPGIYTSLVNYNLWIEKVTQLEGRP 305


>gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  150 bits (378), Expect = 3e-36
 Identities = 85/232 (36%), Positives = 127/232 (54%), Gaps = 18/232 (7%)

Query: 234 RIVGGQECKDGECPWQALLINEENEG--FCGGTILSEFYILTAAHCLYQAKRFKVRVGDR 291
           +IVGG  C++   P+Q  L    N G  FCGG+++SE ++++A HC     R +VR+G+ 
Sbjct: 23  KIVGGYICEENSVPYQVSL----NSGYHFCGGSLISEQWVVSAGHCY--KSRIQVRLGEH 76

Query: 292 NTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAES 351
           N E  EG E       +I+H ++   T D DI +++L +P      V+   LP    A  
Sbjct: 77  NIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVINSRVSAISLPTAPPAAG 136

Query: 352 TLMTQKTGIVSGFGRTHEKGRQ-STRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTK 410
           T       ++SG+G T   G      L+ L+ P + +  C+ S    IT NMFC G+   
Sbjct: 137 T-----ESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKITNNMFCVGFLEG 191

Query: 411 QEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWI 462
            +D+CQGDSGGP V+  +    + GIVSWG GCA+K + G+YTKV  ++ WI
Sbjct: 192 GKDSCQGDSGGPVVSNGE----LQGIVSWGYGCAQKNRPGVYTKVYNYVDWI 239


>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
          Length = 247

 Score =  149 bits (377), Expect = 4e-36
 Identities = 87/257 (33%), Positives = 138/257 (53%), Gaps = 18/257 (7%)

Query: 213 NPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEG--FCGGTILSEFY 270
           NP  +L F         ++  +IVGG  C++   P+Q  L    N G  FCGG++++E +
Sbjct: 2   NPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSL----NSGYHFCGGSLINEQW 57

Query: 271 ILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKT 330
           +++A HC     R +VR+G+ N E  EG E       +I+H ++ ++T + DI +++L +
Sbjct: 58  VVSAGHCY--KSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSS 115

Query: 331 PITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQ-STRLKMLEVPYVDRNS 389
                  V+   LP    A  T       ++SG+G T   G      L+ L+ P + +  
Sbjct: 116 RAVINARVSTISLPTAPPATGTKC-----LISGWGNTASSGADYPDELQCLDAPVLSQAK 170

Query: 390 CKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKY 449
           C+ S    IT NMFC G+    +D+CQGDSGGP V   +    + G+VSWG+GCA+K K 
Sbjct: 171 CEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQ----LQGVVSWGDGCAQKNKP 226

Query: 450 GIYTKVTAFLKWIDRSM 466
           G+YTKV  ++KWI  ++
Sbjct: 227 GVYTKVYNYVKWIKNTI 243


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  149 bits (377), Expect = 4e-36
 Identities = 113/383 (29%), Positives = 168/383 (43%), Gaps = 61/383 (15%)

Query: 95  CQNQGKCKDGLGEYTCTCLEGFEGKNCE--LFTRKLCSLDNGDCDQFCHEEQNSVVCSCA 152
           C     C +GL E  C C   F+ K     +   K+C     DC     EEQ      C 
Sbjct: 474 CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCD-GQPDCLNGSDEEQ------CQ 526

Query: 153 RGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTE 212
            G                PCG  T +   RS  +              KP    D  P  
Sbjct: 527 EGV---------------PCGTFTFQCEDRSCVK--------------KPNPQCDGRP-- 555

Query: 213 NPFDLLDFNQTQPERGDNNL----TRIVGGQECKDGECPWQALLINEENEGFCGGTILSE 268
              D  D   +  E  D  L    +RIVGG    +GE PWQA L        CGG ++++
Sbjct: 556 ---DCRD--GSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASL-QVRGRHICGGALIAD 609

Query: 269 FYILTAAHCLYQAKR-----FKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDI 323
            +++TAAHC  +        + V +G         GE   +V  ++ H    ++++D+D+
Sbjct: 610 RWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDV 669

Query: 324 AVLRLKTPITFRMNVAPACLPERD-WAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEV 382
           A+L+L  P+     V P CLP R  + E  L       ++G+G   E G  S  L+ ++V
Sbjct: 670 ALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCW----ITGWGALREGGPISNALQKVDV 725

Query: 383 PYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTR-FKDTYFVTGIVSWGE 441
             + ++ C     + +T  M CAGY   ++DACQGDSGGP V +     +F+ G+VSWG 
Sbjct: 726 QLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGL 785

Query: 442 GCARKGKYGIYTKVTAFLKWIDR 464
           GC R   +G+YT++T  + WI +
Sbjct: 786 GCGRPNYFGVYTRITGVISWIQQ 808


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  148 bits (374), Expect = 1e-35
 Identities = 89/251 (35%), Positives = 126/251 (50%), Gaps = 9/251 (3%)

Query: 234 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAK---RFKVRVGD 290
           RIVGG E   GE PWQA L  E  E FCG  I++  ++++AAHC  + +   ++   VG 
Sbjct: 202 RIVGGMEASPGEFPWQASL-RENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYVGA 260

Query: 291 RNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAE 350
                 E      +V  ++KH  +  +T DFD+AVL L +P+ F  ++ P CLP    A 
Sbjct: 261 TYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPA---AT 317

Query: 351 STLMTQKTGIVSGFGRTHEKGRQSTR-LKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDT 409
                 K  ++SG+G   E        L+   V  +D+  C       +T  M CAGY  
Sbjct: 318 HIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRMVCAGYLD 377

Query: 410 KQEDACQGDSGGPHVTRFKD-TYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKT 468
            + D+CQGDSGGP V       +F+ GIVSWG GCA   + G+Y +VT    WI  +   
Sbjct: 378 GKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWILEATTK 437

Query: 469 RGLPKAKSHAP 479
             +P A + AP
Sbjct: 438 ASMPLAPTMAP 448



 Score =  148 bits (373), Expect = 1e-35
 Identities = 88/259 (33%), Positives = 134/259 (51%), Gaps = 9/259 (3%)

Query: 233 TRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVR--VGD 290
           TR+VGG     GE PWQ  L  E +  FCG T++ + ++L+AAHC    K  +VR  +G 
Sbjct: 502 TRVVGGFGAASGEVPWQVSL-KEGSRHFCGATVVGDRWLLSAAHCFNHTKVEQVRAHLGT 560

Query: 291 RNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAE 350
            +     G      +  V+ H  +     DFD+AVL L +P+ F   + P CLP    A 
Sbjct: 561 ASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLP---LAI 617

Query: 351 STLMTQKTGIVSGFGRTHE-KGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDT 409
                 +  ++SG+G T E    +   L+   V  +D+ +C +  +F +T  M CAG+  
Sbjct: 618 QKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFSLTDRMICAGFLE 677

Query: 410 KQEDACQGDSGGPHVTR-FKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKT 468
            + D+CQGDSGGP         +++ GIVSWG GCA+  K G+YT++T    WI   M +
Sbjct: 678 GKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILEIMSS 737

Query: 469 RGLPKAKSHAPEVI-TSSP 486
           + LP +      ++ T+SP
Sbjct: 738 QPLPMSPPSTTRMLATTSP 756



 Score =  125 bits (314), Expect = 9e-29
 Identities = 77/240 (32%), Positives = 115/240 (47%), Gaps = 9/240 (3%)

Query: 232  LTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCL---YQAKRFKVRV 288
            LTRIVGG     GE PWQ  L     E  CG  +++E ++L+AAHC       K++   +
Sbjct: 824  LTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFL 883

Query: 289  GDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDW 348
            G       EG   +  V  + KH  +   T D+D+A+L L  P+     V P CLPE   
Sbjct: 884  GTPFLSGAEG--QLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPE--- 938

Query: 349  AESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYD 408
                       +++G+G   E G  + +L+   V  +   +C+      I+  M CAG+ 
Sbjct: 939  PAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFP 998

Query: 409  TKQEDACQGDSGGPHVTRF-KDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMK 467
                D+C GD+GGP   R     + +TG+ SWG GC R    G+YT+V A   WI + ++
Sbjct: 999  QGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQ 1058


>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  147 bits (372), Expect = 2e-35
 Identities = 87/251 (34%), Positives = 133/251 (52%), Gaps = 14/251 (5%)

Query: 213 NPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYIL 272
           NPF +L F         ++  +IVGG  C++   P+Q  L       FCGG+++SE +++
Sbjct: 2   NPFLILAFVGAAVAVPFDDDDKIVGGYTCEENSLPYQVSL--NSGSHFCGGSLISEQWVV 59

Query: 273 TAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPI 332
           +AAHC     R +VR+G+ N +  EG E       +I+H ++ ++T D DI +++L +P 
Sbjct: 60  SAAHCY--KTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPA 117

Query: 333 TFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQ-STRLKMLEVPYVDRNSCK 391
                V+   LP    A  T       ++SG+G T   G      LK L+ P + +  CK
Sbjct: 118 VINARVSTISLPTAPPAAGTEC-----LISGWGNTLSFGADYPDELKCLDAPVLTQAECK 172

Query: 392 LSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGI 451
            S    IT +MFC G+    +D+CQ DSGGP V   +    + G+VSWG GCA K + G+
Sbjct: 173 ASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQ----LQGVVSWGHGCAWKNRPGV 228

Query: 452 YTKVTAFLKWI 462
           YTKV  ++ WI
Sbjct: 229 YTKVYNYVDWI 239


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  146 bits (368), Expect = 5e-35
 Identities = 90/264 (34%), Positives = 138/264 (52%), Gaps = 16/264 (6%)

Query: 228 GDNNL------TRIVGGQECKDGECPWQALLINE--ENEGFCGGTILSEFYILTAAHC-- 277
           GDN++      TRIVGG     GE PWQ  L  +       CGG+++   ++LTAAHC  
Sbjct: 378 GDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFD 437

Query: 278 -LYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRM 336
            L     +++  G  N           +++ +I H  +     + DIA+++L+ P+ +  
Sbjct: 438 GLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTE 497

Query: 337 NVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSC-KLSSS 395
              P CLP +    ST+ T     V+G+G + EKG     L+ + +P V    C K    
Sbjct: 498 FQKPICLPSKG-DTSTIYTNCW--VTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQD 554

Query: 396 FIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKV 455
           + ITQ M CAGY    +DAC+GDSGGP V +    + + GI SWGEGCAR+ + G+YTKV
Sbjct: 555 YKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKV 614

Query: 456 TAFLKWI-DRSMKTRGLPKAKSHA 478
             ++ WI +++  + G  + +S A
Sbjct: 615 AEYMDWILEKTQSSDGKAQMQSPA 638


>gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]
          Length = 304

 Score =  145 bits (367), Expect = 6e-35
 Identities = 82/230 (35%), Positives = 125/230 (54%), Gaps = 14/230 (6%)

Query: 234 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNT 293
           +IVGG  C++   P+Q  L       FCGG+++SE ++++AAHC     R +VR+G+ N 
Sbjct: 80  KIVGGYTCEENSLPYQVSL--NSGSHFCGGSLISEQWVVSAAHCY--KTRIQVRLGEHNI 135

Query: 294 EQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTL 353
           +  EG E       +I+H ++ ++T D DI +++L +P      V+   LP    A  T 
Sbjct: 136 KVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTE 195

Query: 354 MTQKTGIVSGFGRTHEKGRQ-STRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQE 412
                 ++SG+G T   G      LK L+ P + +  CK S    IT +MFC G+    +
Sbjct: 196 C-----LISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGK 250

Query: 413 DACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWI 462
           D+CQ DSGGP V   +    + G+VSWG GCA K + G+YTKV  ++ WI
Sbjct: 251 DSCQRDSGGPVVCNGQ----LQGVVSWGHGCAWKNRPGVYTKVYNYVDWI 296


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  143 bits (360), Expect = 4e-34
 Identities = 88/244 (36%), Positives = 128/244 (52%), Gaps = 11/244 (4%)

Query: 233 TRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHC----LYQAKRFKVRV 288
           +RIVGG+    G  PWQ  L + +N   CGG+I++  +I+TAAHC    L     +    
Sbjct: 291 SRIVGGESALPGAWPWQVSL-HVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFA 349

Query: 289 GDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDW 348
           G         G A ++VE VI H  +  +T + DIA+++L+ P+TF   V P CLP    
Sbjct: 350 GILRQSFMFYG-AGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGM 408

Query: 349 AESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSF--IITQNMFCAG 406
               L  ++   +SG+G T EKG+ S  L   +V  ++   C     +  +IT  M CAG
Sbjct: 409 M---LQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAG 465

Query: 407 YDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSM 466
           +     D+CQGDSGGP VT   + +++ G  SWG GCA+  + G+Y  V  F  WI R M
Sbjct: 466 FLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM 525

Query: 467 KTRG 470
           +  G
Sbjct: 526 RADG 529


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  143 bits (360), Expect = 4e-34
 Identities = 88/244 (36%), Positives = 128/244 (52%), Gaps = 11/244 (4%)

Query: 233 TRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHC----LYQAKRFKVRV 288
           +RIVGG+    G  PWQ  L + +N   CGG+I++  +I+TAAHC    L     +    
Sbjct: 254 SRIVGGESALPGAWPWQVSL-HVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFA 312

Query: 289 GDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDW 348
           G         G A ++VE VI H  +  +T + DIA+++L+ P+TF   V P CLP    
Sbjct: 313 GILRQSFMFYG-AGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGM 371

Query: 349 AESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSF--IITQNMFCAG 406
               L  ++   +SG+G T EKG+ S  L   +V  ++   C     +  +IT  M CAG
Sbjct: 372 M---LQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAG 428

Query: 407 YDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSM 466
           +     D+CQGDSGGP VT   + +++ G  SWG GCA+  + G+Y  V  F  WI R M
Sbjct: 429 FLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM 488

Query: 467 KTRG 470
           +  G
Sbjct: 489 RADG 492


>gi|4506143 neurotrypsin precursor [Homo sapiens]
          Length = 875

 Score =  143 bits (360), Expect = 4e-34
 Identities = 90/245 (36%), Positives = 132/245 (53%), Gaps = 21/245 (8%)

Query: 234 RIVGGQECKDGECPWQALLINEENEG----FCGGTILSEFYILTAAHCLYQ----AKRFK 285
           RI+GG+    G  PWQ  L  + + G     CG T+LS  ++LTAAHC  +     + + 
Sbjct: 630 RIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRSYA 689

Query: 286 VRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTP----ITFRMNVAPA 341
           VRVGD +T   E  E    V+ ++ H  +  +  D+DIA++RL+ P      F  +V PA
Sbjct: 690 VRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQGPEEQCARFSSHVLPA 749

Query: 342 CLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTR-LKMLEVPYVDRNSCKLSSSFIITQ 400
           CLP   W E    T     ++G+G T   GR  +R L+   +P + +  C+       T 
Sbjct: 750 CLPL--WRERPQKTASNCYITGWGDT---GRAYSRTLQQAAIPLLPKRFCEERYKGRFTG 804

Query: 401 NMFCAG--YDTKQEDACQGDSGGPHVT-RFKDTYFVTGIVSWGEGCARKGKYGIYTKVTA 457
            M CAG  ++ K+ D+CQGDSGGP +  R  +++ V G+ SWG GC  K   G+YTKV+A
Sbjct: 805 RMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPGVYTKVSA 864

Query: 458 FLKWI 462
           F+ WI
Sbjct: 865 FVPWI 869


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  142 bits (357), Expect = 9e-34
 Identities = 84/247 (34%), Positives = 127/247 (51%), Gaps = 18/247 (7%)

Query: 232 LTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKR---FKVRV 288
           L R+VGGQ+ ++GE PWQ + I      FCGG++++E ++LTAAHC         ++V +
Sbjct: 32  LNRMVGGQDTQEGEWPWQ-VSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSETSLYQVLL 90

Query: 289 GDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDW 348
           G R   Q         V  V  +  +       D+A++ L+ P+ F   + P CLP+   
Sbjct: 91  GARQLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYILPVCLPDPSV 150

Query: 349 AESTLMTQKTGIVSGFGRTHEKGR--QSTRLKMLEVPYVDRNSCKLSSSF---------I 397
              T M      V+G+G   E+    +   L+ L VP +D   C L  S           
Sbjct: 151 IFETGMNCW---VTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKT 207

Query: 398 ITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTA 457
           I  +M CAG++  ++DAC+GDSGGP V     ++   G++SWGEGCAR+ + G+Y +VTA
Sbjct: 208 IKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQNRPGVYIRVTA 267

Query: 458 FLKWIDR 464
              WI R
Sbjct: 268 HHNWIHR 274


>gi|21264363 mannan-binding lectin serine protease 2 isoform 1
           precursor [Homo sapiens]
          Length = 686

 Score =  141 bits (356), Expect = 1e-33
 Identities = 85/244 (34%), Positives = 130/244 (53%), Gaps = 21/244 (8%)

Query: 234 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKR----FKVRVG 289
           RI GGQ+ K G+ PWQ L++         G +L + ++LTAAH +Y+ K       +R+G
Sbjct: 444 RIYGGQKAKPGDFPWQVLILGGTT---AAGALLYDNWVLTAAHAVYEQKHDASALDIRMG 500

Query: 290 DRNTEQEEGGEAVHEVEVVIKHNRFTKET-YDFDIAVLRLKTPITFRMNVAPACLPERDW 348
                     +A  E   V  H  +T +  +D DIA+++L   +    N+ P CLP ++ 
Sbjct: 501 TLKRLSPHYTQAWSEA--VFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKE- 557

Query: 349 AESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSF------IITQNM 402
           AES + T   G  SG+G T ++G  +  L  +++P VD   C  +          +T NM
Sbjct: 558 AESFMRTDDIGTASGWGLT-QRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANM 616

Query: 403 FCAGYDTKQEDACQGDSGGPHVTRFKDT--YFVTGIVSWGE-GCARKGKYGIYTKVTAFL 459
            CAG ++  +D+C+GDSGG  V    +T  +FV GIVSWG   C   G+YG+YTKV  ++
Sbjct: 617 LCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYI 676

Query: 460 KWID 463
            WI+
Sbjct: 677 PWIE 680



 Score = 33.5 bits (75), Expect = 0.45
 Identities = 12/29 (41%), Positives = 13/29 (44%)

Query: 136 CDQFCHEEQNSVVCSCARGYTLADNGKAC 164
           CD  CH       CSC  GY L  N + C
Sbjct: 152 CDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  141 bits (356), Expect = 1e-33
 Identities = 83/263 (31%), Positives = 134/263 (50%), Gaps = 20/263 (7%)

Query: 234 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCL---YQAKRFKVRVGD 290
           RI GG     G+ PWQ + I  E    CGG+++SE ++L+AAHC    +  + ++V++G 
Sbjct: 44  RITGGSSAVAGQWPWQ-VSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGA 102

Query: 291 RNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAE 350
              +       V  ++ +I H  + +E    DIA+L+L  PITF   + P CLP    A 
Sbjct: 103 HQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPA---AN 159

Query: 351 STLMTQKTGIVSGFGRTHEKGRQSTR--LKMLEVPYVDRNSC--------KLSSSFIITQ 400
           ++        V+G+G         T   L+ LEVP + R +C        K      + +
Sbjct: 160 ASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQE 219

Query: 401 NMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLK 460
           +M CAGY    +DACQGDSGGP     +  +++TGIVSWG+ C  + + G+YT  +++  
Sbjct: 220 DMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYAS 279

Query: 461 WID---RSMKTRGLPKAKSHAPE 480
           WI      ++ R +P+ +   P+
Sbjct: 280 WIQSKVTELQPRVVPQTQESQPD 302


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  141 bits (356), Expect = 1e-33
 Identities = 89/245 (36%), Positives = 124/245 (50%), Gaps = 27/245 (11%)

Query: 233 TRIVGGQECKDGECPWQALLINEENEGF---CGGTILSEFYILTAAHCLYQAKRFKVRVG 289
           +RIVGGQ    G  PWQA +      GF   CGG++L+  +++TAAHC++       R+ 
Sbjct: 216 SRIVGGQSVAPGRWPWQASVAL----GFRHTCGGSVLAPRWVVTAAHCMHS-----FRLA 266

Query: 290 DRNTEQEEGGEAVHE---------VEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAP 340
             ++ +   G   H          VE +I H  ++ + +D+D+A+LRL+T + F   V  
Sbjct: 267 RLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGA 326

Query: 341 ACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQST-RLKMLEVPYVDRNSCKLSSSF--I 397
            CLP +   E          VSG+G TH     S+  L+   VP      C  S  +   
Sbjct: 327 VCLPAK---EQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGA 383

Query: 398 ITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTA 457
           +T  M CAGY   + DACQGDSGGP V    DT+ + G+VSWG GCA     G+Y KV  
Sbjct: 384 LTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAE 443

Query: 458 FLKWI 462
           FL WI
Sbjct: 444 FLDWI 448


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  140 bits (354), Expect = 2e-33
 Identities = 87/243 (35%), Positives = 130/243 (53%), Gaps = 16/243 (6%)

Query: 233 TRIVGGQECKDGECPWQALLINEENEGF--CGGTILSEFYILTAAHC---LYQAKRFKVR 287
           +RIVGG      + PWQA L   + +G+  CGG++++  +I+TAAHC   LY  K + ++
Sbjct: 215 SRIVGGNMSLLSQWPWQASL---QFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQ 271

Query: 288 VGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERD 347
           VG       +     H VE ++ H+++  +    DIA+++L  P+TF   + P CLP   
Sbjct: 272 VG--LVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPN-- 327

Query: 348 WAESTLMTQKTGIVSGFGRTHE-KGRQSTRLKMLEVPYVDRNSCKLSSSF--IITQNMFC 404
            +E      K    SG+G T +  G  S  L    VP +    C     +  II+ +M C
Sbjct: 328 -SEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLC 386

Query: 405 AGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDR 464
           AGY T   D+CQGDSGGP V + +  + + G  S+G GCA   K G+YT+VT+FL WI  
Sbjct: 387 AGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHE 446

Query: 465 SMK 467
            M+
Sbjct: 447 QME 449


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  140 bits (352), Expect = 3e-33
 Identities = 111/389 (28%), Positives = 167/389 (42%), Gaps = 31/389 (7%)

Query: 95  CQNQGKCKDGLGEYTCTCLEG--FEGKNCELFTRKLCSLDNGDCDQF--CHEEQNSVVCS 150
           C     C D   E  C+C  G  F  KN      K C      CD    C +  +   CS
Sbjct: 471 CDGWADCTDHSDELNCSCDAGHQFTCKN------KFCKPLFWVCDSVNDCGDNSDEQGCS 524

Query: 151 CARGYTLADNGKACIPT----GPYPCGKQTLERR--KRSVAQATSSSGEAPDSITWKPYD 204
           C        NGK    +    G   CG  + E    K +V   T  +    + +     +
Sbjct: 525 CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGN 584

Query: 205 AADLDPTENPFDLLDFNQTQPE-RGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGG 263
             + D  E+  D  D        R      R+VGG +  +GE PWQ  L        CG 
Sbjct: 585 P-ECDGKEDCSDGSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGA 643

Query: 264 TILSEFYILTAAHCLYQAKRFKVR--------VGDRNTEQEEG-GEAVHEVEVVIKHNRF 314
           +++S  ++++AAHC    + F+          +G  +  Q    G     ++ +I H  F
Sbjct: 644 SLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFF 703

Query: 315 TKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQS 374
              T+D+DIA+L L+ P  +   V P CLP+   A       K   V+G+G T   G  +
Sbjct: 704 NDFTFDYDIALLELEKPAEYSSMVRPICLPD---ASHVFPAGKAIWVTGWGHTQYGGTGA 760

Query: 375 TRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKD-TYFV 433
             L+  E+  +++ +C+      IT  M C G+ +   D+CQGDSGGP  +   D   F 
Sbjct: 761 LILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQ 820

Query: 434 TGIVSWGEGCARKGKYGIYTKVTAFLKWI 462
            G+VSWG+GCA++ K G+YT++  F  WI
Sbjct: 821 AGVVSWGDGCAQRNKPGVYTRLPLFRDWI 849


>gi|66347875 complement component 1, r subcomponent [Homo sapiens]
          Length = 705

 Score =  139 bits (351), Expect = 4e-33
 Identities = 92/251 (36%), Positives = 134/251 (53%), Gaps = 28/251 (11%)

Query: 234 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKR-------FKV 286
           RI+GGQ+ K G  PWQ +  N    G  GG +L + +ILTAAH LY  +          V
Sbjct: 463 RIIGGQKAKMGNFPWQ-VFTNIHGRG--GGALLGDRWILTAAHTLYPKEHEAQSNASLDV 519

Query: 287 RVGDRNTEQ--EEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLP 344
            +G  N E+  + G   +  V V   + +     ++ DIA+L L+  +T   N+ P CLP
Sbjct: 520 FLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLP 579

Query: 345 ERD-WAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCK-----LSSSFII 398
           + D + +  LM    G VSGFG   EK      L+ + +P  +  +C+      +   + 
Sbjct: 580 DNDTFYDLGLM----GYVSGFGVMEEKIAHD--LRFVRLPVANPQACENWLRGKNRMDVF 633

Query: 399 TQNMFCAGYDTKQEDACQGDSGGPHVTRFKDT--YFVTGIVSWGEGCARKGKYGIYTKVT 456
           +QNMFCAG+ + ++DACQGDSGG    R  +T  +  TGIVSWG GC+R   YG YTKV 
Sbjct: 634 SQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSR--GYGFYTKVL 691

Query: 457 AFLKWIDRSMK 467
            ++ WI + M+
Sbjct: 692 NYVDWIKKEME 702



 Score = 29.3 bits (64), Expect = 8.5
 Identities = 10/29 (34%), Positives = 13/29 (44%)

Query: 136 CDQFCHEEQNSVVCSCARGYTLADNGKAC 164
           C   CH       CSC  GY L ++  +C
Sbjct: 161 CQHLCHNYVGGYFCSCRPGYELQEDRHSC 189


>gi|4758502 hyaluronan binding protein 2 preproprotein [Homo
           sapiens]
          Length = 560

 Score =  139 bits (350), Expect = 6e-33
 Identities = 117/412 (28%), Positives = 181/412 (43%), Gaps = 42/412 (10%)

Query: 90  CETSPCQNQGKCK--DGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSV 147
           C  +PCQN   C       ++TC C + F+GK CE+ +      D        +   N  
Sbjct: 154 CRPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQH 213

Query: 148 VCSCARGYTLADNGKACI--PTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDA 205
            C     + L              +  G+    R   +  +         D + W+  D 
Sbjct: 214 ACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDV 273

Query: 206 A----------DLDPTENPFDLLDFNQT-QPERGDNNLTRIVGGQECKDGECPWQA---- 250
           +          +  PTE    L  F+   + E  +  + RI GG +   G+ PWQA    
Sbjct: 274 SACSAQDVAYPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQS 333

Query: 251 ---LLINEENEGFCGGTILSEFYILTAAHCL-YQAKRFKVRVGDRNTEQEEGGEAVHEVE 306
              L I+     FCGG ++   ++LTAAHC   + +  KV +GD++ ++EE  E    VE
Sbjct: 334 SLPLTISMPQGHFCGGALIHPCWVLTAAHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVE 393

Query: 307 VVIKHNRFTK--ETYDFDIAVLRLKTPITFRMN-----VAPACLPERDWAESTLMTQKTG 359
            + K++ + +  E    DIA+L+LK P+          V   CLP+  +   +       
Sbjct: 394 KIFKYSHYNERDEIPHNDIALLKLK-PVDGHCALESKYVKTVCLPDGSFPSGSECH---- 448

Query: 360 IVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSF--IITQNMFCAGYDTKQ-EDACQ 416
            +SG+G T E G+ S +L   +V  +    C     +  +I  +M CAG   K  +D CQ
Sbjct: 449 -ISGWGVT-ETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQ 506

Query: 417 GDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKT 468
           GDSGGP       TY+V GIVSWG  C ++   G+YT+VT FL WI  ++K+
Sbjct: 507 GDSGGPLTCEKDGTYYVYGIVSWGLECGKRP--GVYTQVTKFLNWIKATIKS 556



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 31/109 (28%), Positives = 41/109 (37%), Gaps = 6/109 (5%)

Query: 78  NEFWNKYKD-GDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELF--TRKLCSLDNG 134
           N  W   +D  D C+ +PC++ G C      +TC+CL  F G  C+    T K      G
Sbjct: 64  NPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPCGRG 123

Query: 135 DCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPC-GKQTLERRKR 182
            C     +      C C   YT     +      P PC    T  R KR
Sbjct: 124 QC--LITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKR 170


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  139 bits (349), Expect = 8e-33
 Identities = 80/235 (34%), Positives = 122/235 (51%), Gaps = 9/235 (3%)

Query: 234 RIVGGQECKDGECPWQALL--INEENEGFCGGTILSEFYILTAAHCLY---QAKRFKVRV 288
           RIVGG     GE PWQ  L   +      CGG+I+   +ILTAAHC Y     K  +V  
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYS 446

Query: 289 GDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDW 348
           G  N  + +   +   V+ +I H+++      +DIA+L+L+T + +  +  P CLP +  
Sbjct: 447 GILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKG- 505

Query: 349 AESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSC-KLSSSFIITQNMFCAGY 407
             + + T     V+G+G    + +    L+  ++P V    C K      IT  M CAGY
Sbjct: 506 DRNVIYTDCW--VTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGY 563

Query: 408 DTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWI 462
               +DAC+GDSGGP   +  + + + GI SWGEGCA++ + G+YT V  ++ WI
Sbjct: 564 REGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWI 618


>gi|110815798 ovochymase 1 [Homo sapiens]
          Length = 1134

 Score =  138 bits (348), Expect = 1e-32
 Identities = 84/238 (35%), Positives = 127/238 (53%), Gaps = 13/238 (5%)

Query: 234 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKR---FKVRVGD 290
           RI GG+E      PWQ  L     +  CGG I++  +ILTAAHC+        + +  GD
Sbjct: 574 RIAGGEEACPHCWPWQVGL-RFLGDYQCGGAIINPVWILTAAHCVQLKNNPLSWTIIAGD 632

Query: 291 RNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAE 350
            +   +E  E V   + +I H  F   +YD DIA+++L +P+ +   V P CLP    + 
Sbjct: 633 HDRNLKESTEQVRRAKHIIVHEDFNTLSYDSDIALIQLSSPLEYNSVVRPVCLPH---SA 689

Query: 351 STLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFI----ITQNMFCAG 406
             L + +   V+G+G     G  ++RL+ ++V  ++R  C+ +        IT+ M CAG
Sbjct: 690 EPLFSSEICAVTGWGSISADGGLASRLQQIQVHVLEREVCEHTYYSAHPGGITEKMICAG 749

Query: 407 YDTK-QEDACQGDSGGPHVTRFKDTYFVT-GIVSWGEGCARKGKYGIYTKVTAFLKWI 462
           +    ++D CQGDSGGP V R ++  FV  GIVSWG GC +  K G++ +V  FL WI
Sbjct: 750 FAASGEKDFCQGDSGGPLVCRHENGPFVLYGIVSWGAGCVQPWKPGVFARVMIFLDWI 807



 Score =  116 bits (290), Expect = 5e-26
 Identities = 89/284 (31%), Positives = 138/284 (48%), Gaps = 30/284 (10%)

Query: 217 LLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAH 276
           +++    +P  G    +RI   +       PWQ  L ++E+  FCGG+++ E  ++TAAH
Sbjct: 29  MVNMKSKEPAVGSRFFSRISSWRNSTVTGHPWQVSLKSDEHH-FCGGSLIQEDRVVTAAH 87

Query: 277 CL-----YQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETY-DFDIAVLRLKT 330
           CL      Q K   V  G+ +  Q++  E    V  +I H  +    Y   DIA+L LK 
Sbjct: 88  CLDSLSEKQLKNITVTSGEYSLFQKDKQEQNIPVSKIITHPEYNSREYMSPDIALLYLKH 147

Query: 331 PITFRMNVAPACLPERD-WAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNS 389
            + F   V P CLP+ D   E  ++     + SG+G+  +    S  L+ +E+P +D  +
Sbjct: 148 KVKFGNAVQPICLPDSDDKVEPGILC----LSSGWGKISKTSEYSNVLQEMELPIMDDRA 203

Query: 390 CK--LSSSFI--ITQNMFCAGYDTKQEDACQGDSGGPHV-TRFKDTYFVTGIVSWGEGCA 444
           C   L S  +  + + M CAG+     DACQGDSGGP V  R    + + GI SW  GCA
Sbjct: 204 CNTVLKSMNLPPLGRTMLCAGFPDWGMDACQGDSGGPLVCRRGGGIWILAGITSWVAGCA 263

Query: 445 R----------KGKYGIYTKVTAFLKWIDRSMKT---RGLPKAK 475
                      K   GI++KV+  + +I +++ T   RG P +K
Sbjct: 264 GGSVPVRNNHVKASLGIFSKVSELMDFITQNLFTGLDRGQPLSK 307


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  137 bits (346), Expect = 2e-32
 Identities = 82/237 (34%), Positives = 118/237 (49%), Gaps = 18/237 (7%)

Query: 234 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNT 293
           RI+GG E ++G  PWQ  L    N   CGG++++  +ILTAAHC      F+     R+ 
Sbjct: 186 RILGGTEAEEGSWPWQVSL-RLNNAHHCGGSLINNMWILTAAHC------FRSNSNPRDW 238

Query: 294 EQEEGGEAVH-----EVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDW 348
               G           V  ++ HN +   T++ DIA++RL+  +TF  ++   CLP    
Sbjct: 239 IATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPA--- 295

Query: 349 AESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSF--IITQNMFCAG 406
           A   +    T  V+G+G     G     L+  +V  +  + C    S+   I   M CAG
Sbjct: 296 ATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAG 355

Query: 407 YDTKQEDACQGDSGGPHVTR-FKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWI 462
                 DACQGDSGGP V    +  +F+ GIVSWG+ C    K G+YT+VTA+L WI
Sbjct: 356 VPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWI 412


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,179,508
Number of Sequences: 37866
Number of extensions: 967525
Number of successful extensions: 4898
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 304
Number of HSP's successfully gapped in prelim test: 125
Number of HSP's that attempted gapping in prelim test: 2466
Number of HSP's gapped (non-prelim): 1517
length of query: 488
length of database: 18,247,518
effective HSP length: 106
effective length of query: 382
effective length of database: 14,233,722
effective search space: 5437281804
effective search space used: 5437281804
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.