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Search of human proteins with 4503579
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform
a [Homo sapiens]
(1005 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 1981 0.0
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 1217 0.0
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 1217 0.0
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 707 0.0
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 694 0.0
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 622 e-178
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 620 e-177
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 582 e-166
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 570 e-162
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 310 3e-84
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 292 1e-78
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 273 6e-73
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 273 6e-73
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 267 4e-71
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 256 7e-68
gi|117500790 FERM domain containing 3 [Homo sapiens] 254 2e-67
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 250 4e-66
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 246 6e-65
gi|34916000 FERM domain containing 7 [Homo sapiens] 236 1e-61
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 225 2e-58
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 225 2e-58
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 160 6e-39
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i... 150 4e-36
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 150 4e-36
gi|161702986 ezrin [Homo sapiens] 142 2e-33
gi|21614499 ezrin [Homo sapiens] 142 2e-33
gi|4505257 moesin [Homo sapiens] 139 2e-32
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 133 1e-30
gi|4506467 radixin [Homo sapiens] 131 4e-30
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 128 2e-29
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 1981 bits (5133), Expect = 0.0
Identities = 1005/1005 (100%), Positives = 1005/1005 (100%)
Query: 1 MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR 60
MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR
Sbjct: 1 MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR 60
Query: 61 RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE 120
RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE
Sbjct: 61 RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE 120
Query: 121 EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET 180
EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET
Sbjct: 121 EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET 180
Query: 181 QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG 240
QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG
Sbjct: 181 QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG 240
Query: 241 QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD 300
QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD
Sbjct: 241 QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD 300
Query: 301 PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE 360
PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE
Sbjct: 301 PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE 360
Query: 361 FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK 420
FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK
Sbjct: 361 FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK 420
Query: 421 LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA 480
LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA
Sbjct: 421 LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA 480
Query: 481 AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE 540
AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE
Sbjct: 481 AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE 540
Query: 541 RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT 600
RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT
Sbjct: 541 RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT 600
Query: 601 KAPHLQLIEGKKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTP 660
KAPHLQLIEGKKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTP
Sbjct: 601 KAPHLQLIEGKKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTP 660
Query: 661 EPRPNEWEKRRITPLSLQTQGSSHETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGP 720
EPRPNEWEKRRITPLSLQTQGSSHETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGP
Sbjct: 661 EPRPNEWEKRRITPLSLQTQGSSHETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGP 720
Query: 721 GEIRKVEPVTQKDSTSLSSESSSSSSESEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEE 780
GEIRKVEPVTQKDSTSLSSESSSSSSESEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEE
Sbjct: 721 GEIRKVEPVTQKDSTSLSSESSSSSSESEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEE 780
Query: 781 PRPAAKVVEREEAVPEASPVTQAGASVITVETVIQENVGAQKIPGEKSVHEGALKQDMGE 840
PRPAAKVVEREEAVPEASPVTQAGASVITVETVIQENVGAQKIPGEKSVHEGALKQDMGE
Sbjct: 781 PRPAAKVVEREEAVPEASPVTQAGASVITVETVIQENVGAQKIPGEKSVHEGALKQDMGE 840
Query: 841 EAEEEPQKVNGEVSHVDIDVLPQIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTE 900
EAEEEPQKVNGEVSHVDIDVLPQIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTE
Sbjct: 841 EAEEEPQKVNGEVSHVDIDVLPQIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTE 900
Query: 901 TKTITYESPQIDGGAGGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVI 960
TKTITYESPQIDGGAGGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVI
Sbjct: 901 TKTITYESPQIDGGAGGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVI 960
Query: 961 TGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED 1005
TGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED
Sbjct: 961 TGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED 1005
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 1217 bits (3150), Expect = 0.0
Identities = 611/611 (100%), Positives = 611/611 (100%)
Query: 1 MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR 60
MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR
Sbjct: 1 MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR 60
Query: 61 RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE 120
RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE
Sbjct: 61 RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE 120
Query: 121 EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET 180
EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET
Sbjct: 121 EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET 180
Query: 181 QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG 240
QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG
Sbjct: 181 QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG 240
Query: 241 QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD 300
QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD
Sbjct: 241 QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD 300
Query: 301 PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE 360
PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE
Sbjct: 301 PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE 360
Query: 361 FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK 420
FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK
Sbjct: 361 FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK 420
Query: 421 LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA 480
LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA
Sbjct: 421 LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA 480
Query: 481 AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE 540
AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE
Sbjct: 481 AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE 540
Query: 541 RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT 600
RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT
Sbjct: 541 RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT 600
Query: 601 KAPHLQLIEGK 611
KAPHLQLIEGK
Sbjct: 601 KAPHLQLIEGK 611
Score = 126 bits (316), Expect = 1e-28
Identities = 63/63 (100%), Positives = 63/63 (100%)
Query: 943 KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 1002
KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE
Sbjct: 611 KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 670
Query: 1003 GED 1005
GED
Sbjct: 671 GED 673
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 1217 bits (3150), Expect = 0.0
Identities = 611/611 (100%), Positives = 611/611 (100%)
Query: 1 MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR 60
MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR
Sbjct: 1 MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR 60
Query: 61 RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE 120
RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE
Sbjct: 61 RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE 120
Query: 121 EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET 180
EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET
Sbjct: 121 EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET 180
Query: 181 QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG 240
QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG
Sbjct: 181 QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG 240
Query: 241 QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD 300
QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD
Sbjct: 241 QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD 300
Query: 301 PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE 360
PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE
Sbjct: 301 PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE 360
Query: 361 FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK 420
FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK
Sbjct: 361 FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK 420
Query: 421 LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA 480
LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA
Sbjct: 421 LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA 480
Query: 481 AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE 540
AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE
Sbjct: 481 AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE 540
Query: 541 RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT 600
RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT
Sbjct: 541 RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT 600
Query: 601 KAPHLQLIEGK 611
KAPHLQLIEGK
Sbjct: 601 KAPHLQLIEGK 611
Score = 126 bits (316), Expect = 1e-28
Identities = 63/63 (100%), Positives = 63/63 (100%)
Query: 943 KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 1002
KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE
Sbjct: 611 KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 670
Query: 1003 GED 1005
GED
Sbjct: 671 GED 673
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 707 bits (1825), Expect = 0.0
Identities = 422/881 (47%), Positives = 537/881 (60%), Gaps = 76/881 (8%)
Query: 156 PSVSKVEMQPTELVSKEREEKVKETQEDKLEG-GAAKRETKEVQTNELKAEKASQKVTKK 214
P + E P++ ++ E+ + ++D E G ++R T KA+K+ QK+ KK
Sbjct: 40 PEANSNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPS------KAQKSPQKIAKK 93
Query: 215 TKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLD 274
K+ C+VTLLD +EY C++EKH +GQVLFD VCEHLNLLEKDYFGL F ++ QKNWLD
Sbjct: 94 YKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLD 153
Query: 275 PAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHA 334
P+KEIK+Q+R+ PW F F VKFYPPDP+QLTEDITRY+LCLQLR DI +GRLPCSFVTHA
Sbjct: 154 PSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHA 213
Query: 335 LLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQF 394
LLGSY +QAELGDYD EEH +SE +FAP QT+ELEE++ ELHKT+RG++P +A+ F
Sbjct: 214 LLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHF 273
Query: 395 LENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSN 454
LENAK+LSMYGVDLHHAKDSEG+DI LGVCANGLLIY+DRLRINRFAWPKILKISYKRSN
Sbjct: 274 LENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSN 333
Query: 455 FYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSK 514
FYIK+RP E EQFESTIGFKLPNHR+AKRLWKVC+EHHTF+RLVSPE PPK FL +GSK
Sbjct: 334 FYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSK 392
Query: 515 FRYSGRTQAQTRQASTLIDRPAPHFERTSSKR--VSRSLDGAPIGVMDQSLMKDFPGAAG 572
FRYSGRTQAQTRQAS LIDRPAP FER+SSKR +SRSLDGA P +
Sbjct: 393 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEF---------SRPASVS 443
Query: 573 EISAYGPGLVSIAVVQDGDGRR------EVRSPTKAPHLQLIEGKKNSLRVEGDNIYVRH 626
E GP + G+R EVR+PTK L+ RH
Sbjct: 444 ENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELK-----------PEQETTPRH 492
Query: 627 SNLMLEELDKAQEDILKHQASISELKRNFMESTPE--PRPNEWEKRRITPLSLQTQGSSH 684
E LDK ++ +LKHQASI+ELKR E + R +WE+ R P S S
Sbjct: 493 KQ---EFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLP-SSPASPSPK 548
Query: 685 ETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGPGEIRKVE--------PVTQKDSTS 736
T E+ G +E+V E G + + + +K S+
Sbjct: 549 GTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSI 608
Query: 737 LSSESSSSSSESEEEDVGEYRPHHRVTEGTIREEQEYEEEVEE----------EPRPAAK 786
S +SS +E + +G+Y H E R E + + + + A
Sbjct: 609 TVSSTSSLEAEVDFTVIGDY--HGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAP 666
Query: 787 VVEREEAVPEASPVTQAGAS--VITVETVIQENVGAQKIPGEKSVHEGALKQDMGEEAEE 844
+ E E SP A ++ + E V E + + K + A+ Q A +
Sbjct: 667 SQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTR-VSAMD 725
Query: 845 EPQKVNGEVSHVDIDVLPQIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTETKTI 904
Q+V+G S V + I + +T T+ ++ + + + +P QT I
Sbjct: 726 NTQQVDGSAS-----VGREFIATTPSITTETISTTMENSLKSGKGAAAMIPGPQTVATEI 780
Query: 905 TYESPQIDGGAGGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVITGDG 964
SP I G D L + T+E++ST+TTTH+TKTVKGG SETRIEKRI+ITGD
Sbjct: 781 RSLSPII----GKD--VLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDE 834
Query: 965 DIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED 1005
D+D DQALA AI+EA+ QHPDM VT+ VV++ET+ + E D
Sbjct: 835 DVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERD 875
Score = 31.2 bits (69), Expect = 5.1
Identities = 36/131 (27%), Positives = 52/131 (39%), Gaps = 16/131 (12%)
Query: 1 MTTEVGSVSEVKKDS----SQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQ 56
MTTE G SEVKK Q A P A + +++ E+ Q AE
Sbjct: 1 MTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQS 60
Query: 57 SSLRRQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEE 116
+ EK+ SE+ G+S P K QKS + K+ A+ +LD E
Sbjct: 61 LDM----EEKDYSEADGLSERTTP-SKAQKSPQKIA-------KKYKSAICRVTLLDASE 108
Query: 117 PLPEEQRQAKG 127
E ++ +G
Sbjct: 109 YECEVEKHGRG 119
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 694 bits (1791), Expect = 0.0
Identities = 409/843 (48%), Positives = 509/843 (60%), Gaps = 119/843 (14%)
Query: 198 QTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKD 257
+T KA+K+ QK+ KK K+ C+VTLLD +EY C++EKH +GQVLFD VCEHLNLLEKD
Sbjct: 15 RTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKD 74
Query: 258 YFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQL 317
YFGL F ++ QKNWLDP+KEIK+Q+R+ PW F F VKFYPPDP+QLTEDITRY+LCLQL
Sbjct: 75 YFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQL 134
Query: 318 RQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAE 377
R DI +GRLPCSFVTHALLGSY +QAELGDYD EEH +SE +FAP QT+ELEE++ E
Sbjct: 135 RADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIME 194
Query: 378 LHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRI 437
LHKT+RG++P +A+ FLENAK+LSMYGVDLHHAKDSEG+DI LGVCANGLLIY+DRLRI
Sbjct: 195 LHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRI 254
Query: 438 NRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL 497
NRFAWPKILKISYKRSNFYIK+RP E EQFESTIGFKLPNHR+AKRLWKVC+EHHTF+RL
Sbjct: 255 NRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL 314
Query: 498 VSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR--VSRSLDGAP 555
VSPE PPK FL +GSKFRYSGRTQAQTRQAS LIDRPAP FER+SSKR +SRSLDGA
Sbjct: 315 VSPEPPPKG-FLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAE 373
Query: 556 IGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKKNSL 615
P + E GP DGD R E +G+
Sbjct: 374 F---------SRPASVSENHDAGP---------DGDKRDE-------------DGESGGQ 402
Query: 616 RVEGDNIYVRHSNLM--LEELDKAQEDILKHQASISELKRNFMESTPE--PRPNEWEKRR 671
R E + VR + L+ LDK ++ +LKHQASI+ELKR E + R +WE+ R
Sbjct: 403 RSEAEEGEVRTPTKIKELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERER 462
Query: 672 ITPLSLQTQGSSHETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGPGEIRKVE---- 727
P S S T E+ G +E+V E G + +
Sbjct: 463 RLP-SSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLK 521
Query: 728 ----PVTQKDSTSLSSESSSSSSESEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEEPRP 783
+ +K S+ S +SS +E + +G+Y H E R E + +
Sbjct: 522 DNHLAIERKCSSITVSSTSSLEAEVDFTVIGDY--HGSAFEDFSRSLPELDRD------- 572
Query: 784 AAKVVEREEAVPEASPVTQAGASVITVETVIQENVGAQKIPGEKSVHEGALKQDMGEEAE 843
+ + + + + +++GA QD E
Sbjct: 573 -------------------------------KSDSDTEGLLFSRDLNKGAPSQD-DESGG 600
Query: 844 EEPQKVNGEVSHVDIDVLPQIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTETKT 903
E G S D +PQ EP VKTE +T+S + R +I + V +
Sbjct: 601 IEDSPDRGACSTPD---MPQF----EP--VKTETMTVSSLAIRKKIEPEAVLQTRVSAMD 651
Query: 904 ITYESPQIDGGAGG---------------------DSGTLLTAQTITSESVSTTTTTHIT 942
T E+ + G G L + T+E++ST+TTTH+T
Sbjct: 652 NTQEN-SLKSGKGAAAMIPGPQTVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVT 710
Query: 943 KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 1002
KTVKGG SETRIEKRI+ITGD D+D DQALA AI+EA+ QHPDM VT+ VV++ET+ + E
Sbjct: 711 KTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPE 770
Query: 1003 GED 1005
D
Sbjct: 771 ERD 773
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 622 bits (1603), Expect = e-178
Identities = 327/553 (59%), Positives = 395/553 (71%), Gaps = 57/553 (10%)
Query: 218 VQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAK 277
+ CKV+LLD T Y C +EKHAKGQ L +VCEHLNLLE+DYFGL ++ K WLD AK
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 278 EIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLG 337
EIK+Q+R +PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLG
Sbjct: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
Query: 338 SYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLEN 397
SYT+Q+ELGDYDPE HG +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLEN
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
Query: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457
AK+LSMYGVDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+I
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
Query: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRY 517
K+RP E EQ+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S + PK+KFL LGSKFRY
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
Query: 518 SGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAY 577
SGRTQAQTRQAS LIDRPAPHFERT+SKR SRSLDGA +D + P +A I+
Sbjct: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT-- 356
Query: 578 GPGLVSIAVVQDGDGRREV-----------------RSPTKAPHLQLIEGKKNSLRVEGD 620
G V+ V D ++ V P +A KK R++G+
Sbjct: 357 -QGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGE 415
Query: 621 NIYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTPEPRPNEWEKRRITPLSLQTQ 680
NIY+RHSNLMLE+LDK+QE+I KH ASISELK+NFMES PEPRP+EW+KR T
Sbjct: 416 NIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLST------- 468
Query: 681 GSSHETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGPGEIRKVEPVTQKDSTSLSSE 740
S TLNI NG +I G GP P+ + + ++S
Sbjct: 469 HSPFRTLNI--------------------NG-QIPTGEGP-------PLVKTQTVTISDN 500
Query: 741 SSSSSSESEEEDV 753
+++ SE +DV
Sbjct: 501 ANAVKSEIPTKDV 513
Score = 139 bits (351), Expect = 1e-32
Identities = 80/147 (54%), Positives = 96/147 (65%), Gaps = 35/147 (23%)
Query: 858 IDVLPQIICCSEPPVVKTEMVTISDASQ--RTEISTKEVPIVQTETKTITYESPQIDGGA 915
+++ QI PP+VKT+ VTISD + ++EI TK+VPIV TETKTITYE+ Q
Sbjct: 475 LNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQ----- 529
Query: 916 GGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVITGDGDIDHDQALAQA 975
TVKGGISETRIEKRIVITGD DIDHDQ L QA
Sbjct: 530 ----------------------------TVKGGISETRIEKRIVITGDADIDHDQVLVQA 561
Query: 976 IREAREQHPDMSVTRVVVHKETELAEE 1002
I+EA+EQHPDMSVT+VVVH+ETE+A+E
Sbjct: 562 IKEAKEQHPDMSVTKVVVHQETEIADE 588
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 620 bits (1598), Expect = e-177
Identities = 348/683 (50%), Positives = 443/683 (64%), Gaps = 85/683 (12%)
Query: 218 VQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAK 277
+ CKV+LLD T Y C +EKHAKGQ L +VCEHLNLLE+DYFGL ++ K WLD AK
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 278 EIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLG 337
EIK+Q+R +PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLG
Sbjct: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
Query: 338 SYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLEN 397
SYT+Q+ELGDYDPE HG +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLEN
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
Query: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457
AK+LSMYGVDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+I
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
Query: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRY 517
K+RP E EQ+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S + PK+KFL LGSKFRY
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
Query: 518 SGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAY 577
SGRTQAQTRQAS LIDRPAPHFERT+SKR SRSLDGA +D + P +A I+
Sbjct: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT-- 356
Query: 578 GPGLVSIAVVQDGDGRREV------------------------RSPTKA-----PHLQLI 608
G V+ V D ++ V PT+A H+++
Sbjct: 357 -QGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVT 415
Query: 609 -------EGKKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTPE 661
+ +K R++G+NIY+RHSNLMLE+LDK+QE+I KH ASISELK+NFMES PE
Sbjct: 416 VPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPE 475
Query: 662 PRPNEWEKRRITPLSLQTQGSSHETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGPG 721
PRP+EW+KR T S TLNI NG +I G GP
Sbjct: 476 PRPSEWDKRLST-------HSPFRTLNI--------------------NG-QIPTGEGP- 506
Query: 722 EIRKVEPVTQKDSTSLSSESSSSSSESEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEEP 781
P+ + + ++S +++ SE +DV + + + +++
Sbjct: 507 ------PLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGV 560
Query: 782 RPAAKVVEREEAVPEASPVTQAGASVI--TVETVIQENVGAQKIPGEKSV-HEGALKQDM 838
A+ + E P ++ TQ +V ET I++ + I G+ + H+ L Q +
Sbjct: 561 LLTAQTITSE--TPSSTTTTQITKTVKGGISETRIEKRI---VITGDADIDHDQVLVQAI 615
Query: 839 GEEAEEEP-QKVNGEVSHVDIDV 860
E E+ P V V H + ++
Sbjct: 616 KEAKEQHPDMSVTKVVVHQETEI 638
Score = 195 bits (496), Expect = 2e-49
Identities = 124/255 (48%), Positives = 160/255 (62%), Gaps = 19/255 (7%)
Query: 767 IREEQEYEEEVEEEPRPAAKVVER--EEAVPEAS-PVTQAGASVITVETVIQENVGAQKI 823
+++E E E+ E EP A KV + E VP ++ TQ + E + +
Sbjct: 387 VKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLE 446
Query: 824 PGEKSVHE--------GALKQDMGEEAEEE-----PQKVNGEVSHVDIDVLPQIICCSEP 870
+KS E LK++ E E ++++ +++ QI P
Sbjct: 447 DLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGP 506
Query: 871 PVVKTEMVTISDASQ--RTEISTKEVPIVQTETKTITYESPQIDGGAGG-DSGTLLTAQT 927
P+VKT+ VTISD + ++EI TK+VPIV TETKTITYE+ Q D +G D G LLTAQT
Sbjct: 507 PLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQT 566
Query: 928 ITSESVSTTTTTHITKTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMS 987
ITSE+ S+TTTT ITKTVKGGISETRIEKRIVITGD DIDHDQ L QAI+EA+EQHPDMS
Sbjct: 567 ITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMS 626
Query: 988 VTRVVVHKETELAEE 1002
VT+VVVH+ETE+A+E
Sbjct: 627 VTKVVVHQETEIADE 641
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 582 bits (1499), Expect = e-166
Identities = 286/440 (65%), Positives = 353/440 (80%), Gaps = 5/440 (1%)
Query: 116 EPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREE 175
E P+++ + + A + + KEE+ ++ + + E+ KE+E
Sbjct: 10 ESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRREVTDKEQEF 69
Query: 176 KVKETQEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLE 235
+ ++ LE + + +++ K ++ K+ KK K++QCKV LLDG+EY+CD+E
Sbjct: 70 AARAAKQ--LEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVE 127
Query: 236 KHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVK 295
K ++GQVLFDKVCEHLNLLEKDYFGL ++++ QKNWLDPAKEIK+Q+R+ W F+FNVK
Sbjct: 128 KRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVK 187
Query: 296 FYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGS 355
FYPPDP+QL+EDITRY+LCLQLR DI SGRLPCSFVT ALLGSYT+Q+ELGDYDP+E GS
Sbjct: 188 FYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGS 247
Query: 356 IDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSE 415
+SEF+FAP TKELE+KV ELHK+HRG++PA+A+ FLENAK+LSMYGVDLHHAKDSE
Sbjct: 248 DYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSE 307
Query: 416 GVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKL 475
GV+I LGVCA+GLLIY+DRLRINRFAWPK+LKISYKR+NFYIK+RP E EQFESTIGFKL
Sbjct: 308 GVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKL 367
Query: 476 PNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRP 535
PNHRAAKRLWKVCVEHHTF+RL+ PE PPK KFLTLGSKFRYSGRTQAQTR+AS LIDRP
Sbjct: 368 PNHRAAKRLWKVCVEHHTFFRLLLPEAPPK-KFLTLGSKFRYSGRTQAQTRRASALIDRP 426
Query: 536 APHFERTSSKR--VSRSLDG 553
AP+FER+SSKR +SRSLDG
Sbjct: 427 APYFERSSSKRYTMSRSLDG 446
Score = 240 bits (612), Expect = 6e-63
Identities = 169/401 (42%), Positives = 229/401 (57%), Gaps = 49/401 (12%)
Query: 627 SNLMLEELDKAQEDILKHQASISELKRNFME-STPEPRPNEWEKRRIT-PLSLQTQGSSH 684
+ L +EL+K Q+D++KHQ +ISELKR F+E ST NEWEKR T P+ L +
Sbjct: 714 AELKAQELEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLSTSPVRLAAR---Q 770
Query: 685 ETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGPGEIRKVEPVTQKDSTSLSSESSSS 744
E ++E E T++ +G+++ GS EI + +K + + +S+S
Sbjct: 771 EDAPMIEPLVPEE--------TKQSSGEKLMDGS---EIFSLLESARKPTEFIGGVTSTS 819
Query: 745 SS-----ESEEEDVG---EYRPHH------RVTEGTIREEQEYEEEVEEEPRPAAKVVER 790
S E++ E G E HH +V + T+ E+ + +A
Sbjct: 820 QSWVQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGD 879
Query: 791 EEAVPEASPVTQAGASVITVETVIQENVGAQKIPGEKSVHEGALKQDMGEEAEEEPQKVN 850
A P + + S +T GA++ GE+ V + L+Q+ A E Q+
Sbjct: 880 AAAQPAFTGIKGKEGSALTE--------GAKEEGGEE-VAKAVLEQEETAAASRERQEEQ 930
Query: 851 GEVSHVD--IDVLPQIICCSEPPVVKTEMVT---ISDASQRTEISTKEVPIVQTETKTIT 905
H+ ++ P E VKTE ++ +S + EISTKEVP+V TETKTIT
Sbjct: 931 SAAIHISETLEQKPHF----ESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTIT 986
Query: 906 YESPQIDGGAGGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVITGDGD 965
YES Q+D G + G L++AQTITSE+ STTTTTHITKTVKGGISETRIEKRIVITGD D
Sbjct: 987 YESSQVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDAD 1046
Query: 966 IDHDQALAQAIREAREQHPDMSVTRVVVHKETELA-EEGED 1005
IDHDQALAQAI+EA+EQHPDMSVT+VVVHKETE+ E+GED
Sbjct: 1047 IDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED 1087
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 570 bits (1469), Expect = e-162
Identities = 368/879 (41%), Positives = 495/879 (56%), Gaps = 126/879 (14%)
Query: 1 MTTEVGSVSEVKKDSSQL---GTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQS 57
MTTE V+E + Q G +A +E + + Q++ + Q A+ +
Sbjct: 1 MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDT 60
Query: 58 SLRRQ--KREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKE 115
K ++ TSESRG+SR +LK+ KS V+++ G + E DKE
Sbjct: 61 PTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQ---VSEEEGKEVES----------DKE 107
Query: 116 EPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKE---EKPSVSKVEMQPTELVSKE 172
+ E Q + + ++ +K + +P + + + S+S E QP +
Sbjct: 108 KG---EGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQ----- 159
Query: 173 REEKVKETQEDKLEGGAAKRETKEVQTNE----LKAE---KASQKVTKKTKTVQCKVTLL 225
E+++E + +++ G E +++ E KAE KASQK +K + + CKV+LL
Sbjct: 160 --EELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLL 217
Query: 226 DGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRN 285
D T Y C +E WLD AKEIK+Q+R
Sbjct: 218 DDTVYECVVE-----------------------------------TWLDSAKEIKKQVRG 242
Query: 286 LPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAEL 345
+PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLGSYT+Q+EL
Sbjct: 243 VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSEL 302
Query: 346 GDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYG 405
GDYDPE HG +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLENAK+LSMYG
Sbjct: 303 GDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYG 362
Query: 406 VDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELE 465
VDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+IK+RP E E
Sbjct: 363 VDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQE 422
Query: 466 QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQT 525
Q+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S + PK+KFL LGSKFRYSGRTQAQT
Sbjct: 423 QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQT 482
Query: 526 RQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIA 585
RQAS LIDRPAPHFERT+SKR SRSLDGA +D + P +A I+ G V+
Sbjct: 483 RQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT---QGQVAEG 537
Query: 586 VVQDGDGRREVRSPTKAPHLQLIEGKKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQ 645
V D ++ V P E KK E ++LDK+QE+I KH
Sbjct: 538 GVLDASAKKTV-VPKAQKETVKAEVKKED---EPPEQAEPEPTEAWKDLDKSQEEIKKHH 593
Query: 646 ASISELKRNFMESTPEPRPNEWEKRRITPLSLQTQGSSHETLNIVEEKKRAEVGKDERVI 705
ASISELK+NFMES PEPRP+EW+KR T S TLNI
Sbjct: 594 ASISELKKNFMESVPEPRPSEWDKRLST-------HSPFRTLNI---------------- 630
Query: 706 TEEMNGKEISPGSGPGEIRKVEPVTQKDSTSLSSESSSSSSESEEEDVGEYRPHHRVTEG 765
NG +I G GP P+ + + ++S +++ SE +DV +
Sbjct: 631 ----NG-QIPTGEGP-------PLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITY 678
Query: 766 TIREEQEYEEEVEEEPRPAAKVVEREEAVPEASPVTQAGASVI--TVETVIQENVGAQKI 823
+ + +++ A+ + E P ++ TQ +V ET I++ + I
Sbjct: 679 EAAQTDDNSGDLDPGVLLTAQTITSE--TPSSTTTTQITKTVKGGISETRIEKRI---VI 733
Query: 824 PGEKSV-HEGALKQDMGEEAEEEP-QKVNGEVSHVDIDV 860
G+ + H+ L Q + E E+ P V V H + ++
Sbjct: 734 TGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEI 772
Score = 193 bits (491), Expect = 6e-49
Identities = 115/239 (48%), Positives = 153/239 (64%), Gaps = 27/239 (11%)
Query: 767 IREEQEYEEEVEEEPRPAAKVVEREEAVPEASPVTQAGASVITVETVIQENVGAQKIPGE 826
+++E E E+ E EP A K +++ + + + AS+ ++ E+V +
Sbjct: 561 VKKEDEPPEQAEPEPTEAWKDLDKSQ-----EEIKKHHASISELKKNFMESVPEPR---- 611
Query: 827 KSVHEGALKQDMGEEAEEEPQKVNGEVSHVDIDVLPQIICCSEPPVVKTEMVTISDASQ- 885
E ++++ +++ QI PP+VKT+ VTISD +
Sbjct: 612 ---------------PSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANA 656
Query: 886 -RTEISTKEVPIVQTETKTITYESPQIDGGAGG-DSGTLLTAQTITSESVSTTTTTHITK 943
++EI TK+VPIV TETKTITYE+ Q D +G D G LLTAQTITSE+ S+TTTT ITK
Sbjct: 657 VKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITK 716
Query: 944 TVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 1002
TVKGGISETRIEKRIVITGD DIDHDQ L QAI+EA+EQHPDMSVT+VVVH+ETE+A+E
Sbjct: 717 TVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 775
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 310 bits (795), Expect = 3e-84
Identities = 164/363 (45%), Positives = 232/363 (63%), Gaps = 12/363 (3%)
Query: 194 TKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNL 253
T V+ +EL ++ +V C + LLD T + + KH +GQVL D V +HL+L
Sbjct: 12 TYNVRASELARDRQHTEVV-------CNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDL 64
Query: 254 LEKDYFGL-LFQESPEQKNWLDPAKEIKRQL-RNLPWLFTFNVKFYPPDPSQLTEDITRY 311
E+DYFGL L +S + WLDP K I++QL R P+ F VKF+ DP++L E+ TRY
Sbjct: 65 TEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRY 124
Query: 312 FLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL 371
LQ++QDI +GRLPC T ALL S+ +Q+ELGDYD E+ S LS++ F P Q ++
Sbjct: 125 QYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDF 184
Query: 372 EEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIY 431
E+++A+LH+ H GLSPA+A+ +L A+ L +YGV+ H+A+D +I +GV + G+LIY
Sbjct: 185 EKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIY 244
Query: 432 KDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEH 491
K+R+R+N F W KI+KIS+K F+I++R E E+ +GF + N+RA K LWK CVEH
Sbjct: 245 KNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEH 304
Query: 492 HTFYRLVSPEQPPK---AKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVS 548
HTF+RL P P K A + TLGSKFRY GRT+ Q+ Q F R+ SK ++
Sbjct: 305 HTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLA 364
Query: 549 RSL 551
R L
Sbjct: 365 RKL 367
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 292 bits (747), Expect = 1e-78
Identities = 153/337 (45%), Positives = 215/337 (63%), Gaps = 7/337 (2%)
Query: 218 VQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAK 277
+ C+V+LLDGT+ S DL K AKGQ LFD++ HL+L+E DYFGL F +S + +WLD K
Sbjct: 43 ITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTK 102
Query: 278 EIKRQLR-NLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALL 336
IK+Q++ P+ VKFY +P+ L E++TRY LQL+QDI SG+L C F T L
Sbjct: 103 SIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQL 162
Query: 337 GSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLE 396
+Y LQAELGDYD EH +SEF+F P QT+E+E + E K +RG +PAQA++ +L
Sbjct: 163 AAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLN 222
Query: 397 NAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFY 456
AK L MYGVD+H K +G D LG+ G+L+++ +I F WPKI ++ +K++
Sbjct: 223 KAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKLT 282
Query: 457 IKV--RPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPP--KAKFLTLG 512
+ V + ++ E T F+L + +A K LWK VEHH F+RL P Q ++ F+ LG
Sbjct: 283 LVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSHRSGFIRLG 342
Query: 513 SKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSR 549
S+FRYSG+T+ QT + + R + FER SKR SR
Sbjct: 343 SRFRYSGKTEYQTTKTNKA--RRSTSFERRPSKRYSR 377
>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
1 [Homo sapiens]
Length = 518
Score = 273 bits (698), Expect = 6e-73
Identities = 150/335 (44%), Positives = 207/335 (61%), Gaps = 7/335 (2%)
Query: 217 TVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPA 276
T+ C+V LLDGTE S DL KHAKGQ LFD++ HL+L+E DYFGL F +S + +WLD A
Sbjct: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
Query: 277 KEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHAL 335
K IK+Q++ P + F VK+Y +P+ L E+ TRY LQLR DI SG+L C + T
Sbjct: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203
Query: 336 LGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFL 395
L + LQAELG+ + EH +SEF+F P QT+ +E + + K RG SPAQA+ +L
Sbjct: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263
Query: 396 ENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF 455
AK L MYGVD+H + +G + LG+ G+LI++ +I F WPKI K+ +K+S
Sbjct: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323
Query: 456 YIKVRPAELE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSP--EQPPKAKFLTL 511
+ V + + + E T F+L + R K LWK VEHH F+RL +P + ++ F+ L
Sbjct: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383
Query: 512 GSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR 546
GS+FR+SGRT+ Q S L R FER SKR
Sbjct: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
2 [Homo sapiens]
Length = 900
Score = 273 bits (698), Expect = 6e-73
Identities = 150/335 (44%), Positives = 207/335 (61%), Gaps = 7/335 (2%)
Query: 217 TVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPA 276
T+ C+V LLDGTE S DL KHAKGQ LFD++ HL+L+E DYFGL F +S + +WLD A
Sbjct: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
Query: 277 KEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHAL 335
K IK+Q++ P + F VK+Y +P+ L E+ TRY LQLR DI SG+L C + T
Sbjct: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203
Query: 336 LGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFL 395
L + LQAELG+ + EH +SEF+F P QT+ +E + + K RG SPAQA+ +L
Sbjct: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263
Query: 396 ENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF 455
AK L MYGVD+H + +G + LG+ G+LI++ +I F WPKI K+ +K+S
Sbjct: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323
Query: 456 YIKVRPAELE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSP--EQPPKAKFLTL 511
+ V + + + E T F+L + R K LWK VEHH F+RL +P + ++ F+ L
Sbjct: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383
Query: 512 GSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR 546
GS+FR+SGRT+ Q S L R FER SKR
Sbjct: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 267 bits (682), Expect = 4e-71
Identities = 149/350 (42%), Positives = 207/350 (59%), Gaps = 11/350 (3%)
Query: 212 TKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKN 271
T K V K+ +LD T+ + ++ + A G+VL D VC HLNL+E DYFGL F + +
Sbjct: 34 TPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITV 93
Query: 272 WLDPAKEIKRQLRNLPWLFT-FNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSF 330
WLD K I +Q+R + F VKF+PPD +QL E++TRY LQ++QD+A GRL C+
Sbjct: 94 WLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCND 153
Query: 331 VTHALLGSYTLQAELGDYDP---EEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSP 387
+ ALL S+ +Q+E+GD+D EH L++ ++ P Q LE+K+ E H H G +P
Sbjct: 154 TSAALLISHIVQSEIGDFDEALDREH----LAKNKYIPQQDA-LEDKIVEFHHNHIGQTP 208
Query: 388 AQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILK 447
A++D Q LE A+RL MYG+ LH AKD EG I L V G+L+++ +IN F W K+ K
Sbjct: 209 AESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRK 268
Query: 448 ISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLV-SPEQPPKA 506
+S+KR F IK+RP ++ T+ F + + K WK+CVEHH F+RL P+ PK
Sbjct: 269 LSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKP 328
Query: 507 KFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVS-RSLDGAP 555
+ GS FR+SGRTQ Q FER SK S RSL P
Sbjct: 329 VLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQP 378
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 256 bits (654), Expect = 7e-68
Identities = 170/514 (33%), Positives = 258/514 (50%), Gaps = 52/514 (10%)
Query: 220 CKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEI 279
C V LLD +EY+C +++ AKGQ LFD +C HLNLLEKDYFG+ F + +Q++WL+ K +
Sbjct: 19 CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78
Query: 280 KRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGS 338
+QLR+ P + F VKFYP DP+ L E+ITRY + LQ+++D+ GRL C ALL +
Sbjct: 79 VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAA 138
Query: 339 YTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTH-RGLSPAQADSQFLEN 397
Y LQAE+GDYD +H S+FQF P +++LE K+AE+HKT G +PA ++ FL
Sbjct: 139 YILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRK 198
Query: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457
A+ L YGVD H KD G L G ++ + R++ W ++ K+ ++ FY+
Sbjct: 199 AQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYL 258
Query: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTL---GSK 514
V ++ E+ + + + P A K LWK +E+ FY+L Q L GS+
Sbjct: 259 YV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSR 316
Query: 515 FRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEI 574
FRYSGR + ++S I R P R P +
Sbjct: 317 FRYSGRVAKEVMESSAKIKREPPEIHRAGM----------------------VPSRSCPS 354
Query: 575 SAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKKNSLRVEGDNIYVR---HSNLML 631
+GP L S+ R+ +A H+ ++EG + SLR + VR H + L
Sbjct: 355 ITHGPRLSSVP-----------RTRRRAVHISIMEGLE-SLRDSAHSTPVRSTSHGDTFL 402
Query: 632 EELDKAQEDILKHQASISELKRNFMESTPEPRPNEWEKRRITPLSLQTQGSSHETLNIVE 691
+ ++ D + A I++ + +S P P + LS Q G++ +E
Sbjct: 403 PHVRSSRTDSNERVAVIADEAYSPADSV-LPTPVAEHSLELMLLSRQINGATCS----IE 457
Query: 692 EKKRAEVGKDERVITEEMNG--KEISPG-SGPGE 722
E+K +E E + G + + G SGP E
Sbjct: 458 EEKESEASTPTATEVEALGGELRALCQGHSGPEE 491
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 254 bits (650), Expect = 2e-67
Identities = 135/352 (38%), Positives = 203/352 (57%), Gaps = 10/352 (2%)
Query: 208 SQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESP 267
S V ++ ++C + LLD +E SC +++ KGQ L D +C + +LLEKDYFG+ + +
Sbjct: 22 SSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPE 81
Query: 268 EQKNWLDPAKEIKRQLR-NLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRL 326
+Q++WL+P K I +Q++ + P+ F VKFYP +P ++ E++TRY L LQ+++DI GRL
Sbjct: 82 KQRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRL 141
Query: 327 PCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTH-RGL 385
CSF A LG+ +QAELGDYDP+EH +SEF+ P Q+++LE K+ E+HK RG
Sbjct: 142 LCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQ 201
Query: 386 SPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKI 445
SP A+ L A L YGVD H KDS G LG A G ++++ RI+ WP +
Sbjct: 202 SPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDV 261
Query: 446 LKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQ--- 502
K+ ++ FY+ ++ ++ + F A K LWK VE+ FY+ Q
Sbjct: 262 CKLKFEGKTFYV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKT 318
Query: 503 PPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERT--SSKRVSRSLD 552
+K GS+FRYSG+ + +AS+ I R P R + R S SL+
Sbjct: 319 VSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLN 370
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 250 bits (639), Expect = 4e-66
Identities = 145/358 (40%), Positives = 205/358 (57%), Gaps = 20/358 (5%)
Query: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
K + +V LLD T D+E GQVL +V + LNL+E DYFG+ FQ + WL+P
Sbjct: 42 KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101
Query: 276 AKEIKRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHA 334
K I RQ+R + VKF+PPDP QL E+ TRY LQL++D+ RL C+ T A
Sbjct: 102 MKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAA 161
Query: 335 LLGSYTLQAELGDYDP---EEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQAD 391
LL S+ LQ+E+GDYD EH ++ ++ P Q LE K+ E H+ H G +PA++D
Sbjct: 162 LLTSHLLQSEIGDYDETLDREHLKVN----EYLPGQQHCLE-KILEFHQKHVGQTPAESD 216
Query: 392 SQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYK 451
Q LE A++L MYG+ H A D EG I+L V G+L+++ +IN F W K+ K+S+K
Sbjct: 217 FQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFK 276
Query: 452 RSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLV-SPEQPPKAKFLT 510
R F IK+ P ++ T+ F L + K WK+CVE+HTF+RL+ P+ KA F +
Sbjct: 277 RKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFS 336
Query: 511 LGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFP 568
GS FRYSGRTQ Q L+D +F+ + KR+ + ++L D P
Sbjct: 337 RGSSFRYSGRTQKQ------LVD----YFKDSGMKRIPYERRHSKTHTSVRALTADLP 384
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 246 bits (629), Expect = 6e-65
Identities = 135/340 (39%), Positives = 202/340 (59%), Gaps = 16/340 (4%)
Query: 220 CKVTLLDGTEYSCD-----LEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLD 274
C+V LLD ++ + ++K KG V+ D V H+NL+E DYFGL + + Q WLD
Sbjct: 13 CEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLD 72
Query: 275 PAKEIK--RQLRNL--PWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSF 330
PAK + ++L N P+ F +KFY DP +L E+ITRY LQ++QD+ GRLPC
Sbjct: 73 PAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPV 132
Query: 331 VTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQA 390
T A LG+Y +Q+ELGDYDP +H + +SE++F P Q +ELEE + +HKT G P++A
Sbjct: 133 NTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSEA 192
Query: 391 DSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISY 450
+ +L AK L MYGVDLH + LG+ G+++YK++ ++ ++ WP+I K+ +
Sbjct: 193 ELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHF 252
Query: 451 KRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPE----QPPKA 506
K + F ++V + E++ F+ + A K LWK VEHHTF+R+ E +
Sbjct: 253 KETQFELRVLGKDCN--ETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSLSRKLS 310
Query: 507 KFLTLGSKFRYSGRTQAQ-TRQASTLIDRPAPHFERTSSK 545
KF ++ K RYSGRT Q +R S + RP + R+ SK
Sbjct: 311 KFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSK 350
>gi|34916000 FERM domain containing 7 [Homo sapiens]
Length = 714
Score = 236 bits (601), Expect = 1e-61
Identities = 129/306 (42%), Positives = 183/306 (59%), Gaps = 4/306 (1%)
Query: 221 KVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIK 280
KV LD ++ +++ + G+ LF+ C HLNL EK+YFGL F WL+ K I
Sbjct: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
Query: 281 RQLRNLPWL-FTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSY 339
+Q++N + F F VKF+P DP L E++TRY LQ+++D+A GRLPCS AL+ S+
Sbjct: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
Query: 340 TLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAK 399
LQ+ELGD+ EE L++ ++ P Q LE K+ H+ H G SPA++D L+ A+
Sbjct: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182
Query: 400 RLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKV 459
+L MYG+ H A D EG+ I L V G+L+ + +IN F W KI K+S+KR +F IK+
Sbjct: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
Query: 460 RPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL-VSPEQPPKAKFLTLGSKFRYS 518
L + T+ F + + A K WK CVE+H F+RL P+ PK + GS FRYS
Sbjct: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302
Query: 519 GRTQAQ 524
GRTQ Q
Sbjct: 303 GRTQRQ 308
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 225 bits (573), Expect = 2e-58
Identities = 117/323 (36%), Positives = 184/323 (56%), Gaps = 12/323 (3%)
Query: 197 VQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEK 256
++T+EL EK +V C + LDG + + K GQVL D V HL + EK
Sbjct: 15 IRTSELPKEKTRSEVI-------CSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEK 67
Query: 257 DYFGLLFQE-SPEQKNWLDPAKEIKRQLRN-LPWLFTFNVKFYPPDPSQLTEDITRYFLC 314
+YFGL + S + WL+ +K I++QL+ P F V+F+ PDP+ L ++ TR+
Sbjct: 68 EYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYF 127
Query: 315 LQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEK 374
LQL+ DI GRL C + +L SY +Q+ GDY+ H LS+ F P Q ++ K
Sbjct: 128 LQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTK 187
Query: 375 VAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDR 434
V LH+ H GL ++A+S ++ A+ L YGV+LH +D +D+ +G+ + G+ +Y+
Sbjct: 188 VESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKY 247
Query: 435 LRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTF 494
+ + + W ILKIS+KR F+I R + E E + F + N+R+ K LWK CVEHHTF
Sbjct: 248 ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTF 307
Query: 495 Y---RLVSPEQPPKAKFLTLGSK 514
+ +L+ E+ +++ T+GS+
Sbjct: 308 FQAKKLLPQEKNVLSQYWTMGSR 330
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 225 bits (573), Expect = 2e-58
Identities = 117/323 (36%), Positives = 184/323 (56%), Gaps = 12/323 (3%)
Query: 197 VQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEK 256
++T+EL EK +V C + LDG + + K GQVL D V HL + EK
Sbjct: 15 IRTSELPKEKTRSEVI-------CSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEK 67
Query: 257 DYFGLLFQE-SPEQKNWLDPAKEIKRQLRN-LPWLFTFNVKFYPPDPSQLTEDITRYFLC 314
+YFGL + S + WL+ +K I++QL+ P F V+F+ PDP+ L ++ TR+
Sbjct: 68 EYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYF 127
Query: 315 LQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEK 374
LQL+ DI GRL C + +L SY +Q+ GDY+ H LS+ F P Q ++ K
Sbjct: 128 LQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTK 187
Query: 375 VAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDR 434
V LH+ H GL ++A+S ++ A+ L YGV+LH +D +D+ +G+ + G+ +Y+
Sbjct: 188 VESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKY 247
Query: 435 LRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTF 494
+ + + W ILKIS+KR F+I R + E E + F + N+R+ K LWK CVEHHTF
Sbjct: 248 ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTF 307
Query: 495 Y---RLVSPEQPPKAKFLTLGSK 514
+ +L+ E+ +++ T+GS+
Sbjct: 308 FQAKKLLPQEKNVLSQYWTMGSR 330
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 160 bits (405), Expect = 6e-39
Identities = 101/307 (32%), Positives = 154/307 (50%), Gaps = 18/307 (5%)
Query: 202 LKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGL 261
LK ++ + + ++ LL+ L + GQ + V + L L E YF L
Sbjct: 7 LKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSL 66
Query: 262 LFQESPEQKNWLDPAKEIKRQLRNL---PWLFTFNVKFYPPDPSQLTEDITRYFLCLQLR 318
+ Q+ W+D K +K+QL P ++ F V FY P SQL ++ITRY LQL+
Sbjct: 67 WYYNKQNQRRWVDLEKPLKKQLDKYALEPTVY-FGVVFYVPSVSQLQQEITRYQYYLQLK 125
Query: 319 QDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPT----QTKELEE- 373
+DI G +PC+ L +QA+ GD+D E L +F P K LEE
Sbjct: 126 KDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDF-LQKFALFPVGWLQDEKVLEEA 184
Query: 374 --KVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLI- 430
KVA LH+ +RGL+ A+ +++ +R+ YG + + AKDS+G DI +G C G+ +
Sbjct: 185 TQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVK 244
Query: 431 YKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVE 490
+K+ F W I +S+ +S F + EL E TI F+ + AK +W++CV
Sbjct: 245 HKNGRHPVVFRWHDIANMSHNKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLCVA 299
Query: 491 HHTFYRL 497
H FYRL
Sbjct: 300 RHKFYRL 306
>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
Length = 737
Score = 150 bits (380), Expect = 4e-36
Identities = 72/198 (36%), Positives = 116/198 (58%), Gaps = 3/198 (1%)
Query: 320 DIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELH 379
DI GRL C + +L SY +Q+ GDY+ H LS+ F P Q ++ KV LH
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 380 KTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINR 439
+ H GL ++A+S ++ A+ L YGV+LH +D +D+ +G+ + G+ +Y+ + +
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 440 FAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY---R 496
+ W ILKIS+KR F+I R + E E + F + N+R+ K LWK CVEHHTF+ +
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
Query: 497 LVSPEQPPKAKFLTLGSK 514
L+ E+ +++ T+GS+
Sbjct: 182 LLPQEKNVLSQYWTMGSR 199
>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
isoform 3 [Homo sapiens]
Length = 782
Score = 150 bits (380), Expect = 4e-36
Identities = 72/198 (36%), Positives = 116/198 (58%), Gaps = 3/198 (1%)
Query: 320 DIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELH 379
DI GRL C + +L SY +Q+ GDY+ H LS+ F P Q ++ KV LH
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 380 KTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINR 439
+ H GL ++A+S ++ A+ L YGV+LH +D +D+ +G+ + G+ +Y+ + +
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 440 FAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY---R 496
+ W ILKIS+KR F+I R + E E + F + N+R+ K LWK CVEHHTF+ +
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
Query: 497 LVSPEQPPKAKFLTLGSK 514
L+ E+ +++ T+GS+
Sbjct: 182 LLPQEKNVLSQYWTMGSR 199
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 142 bits (358), Expect = 2e-33
Identities = 147/605 (24%), Positives = 256/605 (42%), Gaps = 80/605 (13%)
Query: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
K + +VT +D E ++ + G+ LFD+V + + L E YFGL + ++ WL
Sbjct: 3 KPINVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
Query: 276 AKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVT 332
K++ Q + P F F KFYP D ++ L +DIT+ LQ+++ I S + C T
Sbjct: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
Query: 333 HALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQT--------KELEEKVAELHKTHRG 384
LLGSY +QA+ GDY+ E H S LS + P + + E+++ H HRG
Sbjct: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
Query: 385 LSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFA 441
+ A ++L+ A+ L MYG++ K+ +G D+ LGV A GL IY+ ++ F
Sbjct: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
Query: 442 WPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPE 501
W +I IS+ F IK + F F P R KR+ ++C+ +H Y +
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILQLCMGNHELY--MRRR 295
Query: 502 QPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQ 561
+P + + + QA+ + ++R E+ + V R +
Sbjct: 296 KPDTIEVQQM--------KAQAREEKHQKQLERQQLETEKKRRETVERE---------KE 338
Query: 562 SLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKKNSLRVEGDN 621
+M++ + Y TK +L E + +L++E +
Sbjct: 339 QMMREKEELMLRLQDY-------------------EEKTKKAERELSEQIQRALQLEEER 379
Query: 622 IYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTPEPRPNEWEKRRIT-PLSLQTQ 680
+ EE ++ + D + + EL+R ++ E T ++L +
Sbjct: 380 KRAQ------EEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEE 433
Query: 681 GSSHETLNIVEEKKRAEVGKDERVIT-EEMNGKEISPGSGPGEIRKVEPVTQKDSTSLSS 739
+ + E + RA+ +D+ V T EE++ +P P + EPV+ SL
Sbjct: 434 ARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPV--YEPVSYHVQESLQD 491
Query: 740 E-------SSSSSSE------SEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEEPRPAAK 786
E S+ SSE +EE+ + E + RV + E + +E R
Sbjct: 492 EGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHND 551
Query: 787 VVERE 791
++ E
Sbjct: 552 IIHNE 556
Score = 35.4 bits (80), Expect = 0.27
Identities = 44/202 (21%), Positives = 86/202 (42%), Gaps = 19/202 (9%)
Query: 21 DATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPP 80
+ TK+ +E++E Q EE K +Q A ++ R KE E + + +
Sbjct: 356 EKTKKAERELSEQIQRALQLEEERKRAQEE-AERLEADRMAALRAKEELERQAVDQ---- 410
Query: 81 WLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIK 140
+K Q+ +A+ A++EE KE+ + E Q +AK +++ + K+E+
Sbjct: 411 -IKSQEQLAAELAE-----YTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELH 464
Query: 141 VEVKEEKP-------SVSKEEKPSVSKVEMQPTELVSKEREEKVKETQ-EDKLEGGAAKR 192
+ + P VS + S+ +PT ++ E +++ + E+K A K
Sbjct: 465 LVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKN 524
Query: 193 ETKEVQTNELKAEKASQKVTKK 214
E + Q L +E + + K
Sbjct: 525 ERVQRQLLTLSSELSQARDENK 546
Score = 32.3 bits (72), Expect = 2.3
Identities = 43/199 (21%), Positives = 85/199 (42%), Gaps = 21/199 (10%)
Query: 123 RQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQE 182
R+ K D E+ Q++K + +EEK K+ + + E + E V +E+E+ ++E +E
Sbjct: 293 RRRKPDTIEV----QQMKAQAREEKH--QKQLERQQLETEKKRRETVEREKEQMMREKEE 346
Query: 183 DKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSC-----DLEKH 237
L + +TK+ + + + + ++ ++ K Q + L+ + +LE+
Sbjct: 347 LMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQ 406
Query: 238 AKGQVLFDKVCEHLNLLEKDYFG--LLFQESPEQK-----NWLDPAKEIKRQLRNLPWLF 290
A Q+ K E L +Y L +E+ +K W AKE + L
Sbjct: 407 AVDQI---KSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEEL 463
Query: 291 TFNVKFYPPDPSQLTEDIT 309
+ PP P + E ++
Sbjct: 464 HLVMTAPPPPPPPVYEPVS 482
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 142 bits (358), Expect = 2e-33
Identities = 147/605 (24%), Positives = 256/605 (42%), Gaps = 80/605 (13%)
Query: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
K + +VT +D E ++ + G+ LFD+V + + L E YFGL + ++ WL
Sbjct: 3 KPINVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
Query: 276 AKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVT 332
K++ Q + P F F KFYP D ++ L +DIT+ LQ+++ I S + C T
Sbjct: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
Query: 333 HALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQT--------KELEEKVAELHKTHRG 384
LLGSY +QA+ GDY+ E H S LS + P + + E+++ H HRG
Sbjct: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
Query: 385 LSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFA 441
+ A ++L+ A+ L MYG++ K+ +G D+ LGV A GL IY+ ++ F
Sbjct: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
Query: 442 WPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPE 501
W +I IS+ F IK + F F P R KR+ ++C+ +H Y +
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILQLCMGNHELY--MRRR 295
Query: 502 QPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQ 561
+P + + + QA+ + ++R E+ + V R +
Sbjct: 296 KPDTIEVQQM--------KAQAREEKHQKQLERQQLETEKKRRETVERE---------KE 338
Query: 562 SLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKKNSLRVEGDN 621
+M++ + Y TK +L E + +L++E +
Sbjct: 339 QMMREKEELMLRLQDY-------------------EEKTKKAERELSEQIQRALQLEEER 379
Query: 622 IYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTPEPRPNEWEKRRIT-PLSLQTQ 680
+ EE ++ + D + + EL+R ++ E T ++L +
Sbjct: 380 KRAQ------EEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEE 433
Query: 681 GSSHETLNIVEEKKRAEVGKDERVIT-EEMNGKEISPGSGPGEIRKVEPVTQKDSTSLSS 739
+ + E + RA+ +D+ V T EE++ +P P + EPV+ SL
Sbjct: 434 ARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPV--YEPVSYHVQESLQD 491
Query: 740 E-------SSSSSSE------SEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEEPRPAAK 786
E S+ SSE +EE+ + E + RV + E + +E R
Sbjct: 492 EGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHND 551
Query: 787 VVERE 791
++ E
Sbjct: 552 IIHNE 556
Score = 35.4 bits (80), Expect = 0.27
Identities = 44/202 (21%), Positives = 86/202 (42%), Gaps = 19/202 (9%)
Query: 21 DATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPP 80
+ TK+ +E++E Q EE K +Q A ++ R KE E + + +
Sbjct: 356 EKTKKAERELSEQIQRALQLEEERKRAQEE-AERLEADRMAALRAKEELERQAVDQ---- 410
Query: 81 WLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIK 140
+K Q+ +A+ A++EE KE+ + E Q +AK +++ + K+E+
Sbjct: 411 -IKSQEQLAAELAE-----YTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELH 464
Query: 141 VEVKEEKP-------SVSKEEKPSVSKVEMQPTELVSKEREEKVKETQ-EDKLEGGAAKR 192
+ + P VS + S+ +PT ++ E +++ + E+K A K
Sbjct: 465 LVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKN 524
Query: 193 ETKEVQTNELKAEKASQKVTKK 214
E + Q L +E + + K
Sbjct: 525 ERVQRQLLTLSSELSQARDENK 546
Score = 32.3 bits (72), Expect = 2.3
Identities = 43/199 (21%), Positives = 85/199 (42%), Gaps = 21/199 (10%)
Query: 123 RQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQE 182
R+ K D E+ Q++K + +EEK K+ + + E + E V +E+E+ ++E +E
Sbjct: 293 RRRKPDTIEV----QQMKAQAREEKH--QKQLERQQLETEKKRRETVEREKEQMMREKEE 346
Query: 183 DKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSC-----DLEKH 237
L + +TK+ + + + + ++ ++ K Q + L+ + +LE+
Sbjct: 347 LMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQ 406
Query: 238 AKGQVLFDKVCEHLNLLEKDYFG--LLFQESPEQK-----NWLDPAKEIKRQLRNLPWLF 290
A Q+ K E L +Y L +E+ +K W AKE + L
Sbjct: 407 AVDQI---KSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEEL 463
Query: 291 TFNVKFYPPDPSQLTEDIT 309
+ PP P + E ++
Sbjct: 464 HLVMTAPPPPPPPVYEPVS 482
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 139 bits (349), Expect = 2e-32
Identities = 95/294 (32%), Positives = 150/294 (51%), Gaps = 19/294 (6%)
Query: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
KT+ +VT +D E ++ + G+ LFD+V + + L E +FGL +Q++ WL
Sbjct: 3 KTISVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
Query: 276 AKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVT 332
K++ Q + P LF F KFYP D S+ L +DIT+ LQ+++ I + + C T
Sbjct: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
Query: 333 HALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL--------EEKVAELHKTHRG 384
LL SY +Q++ GD++ E H S L+ + P + E EE++ H+ HRG
Sbjct: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
Query: 385 LSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFA 441
+ A ++L+ A+ L MYGV+ K+ +G ++ LGV A GL IY+ R+ F
Sbjct: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
Query: 442 WPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495
W +I IS+ F IK + F F P R KR+ +C+ +H Y
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNHELY 291
Score = 38.5 bits (88), Expect = 0.032
Identities = 28/143 (19%), Positives = 69/143 (48%), Gaps = 8/143 (5%)
Query: 81 WLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIK 140
+++++K T+ V ++ QA E+ E + E +++ + AE+ +K + K
Sbjct: 291 YMRRRKPDTIEV------QQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREK 344
Query: 141 VEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQEDKLEGGAAKRETKEVQTN 200
E+ E + ++ K + ++E Q + E+E K +++ +KL ++E +E +
Sbjct: 345 EELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKL--AKERQEAEEAKEA 402
Query: 201 ELKAEKASQKVTKKTKTVQCKVT 223
L+A + +K ++ ++T
Sbjct: 403 LLQASRDQKKTQEQLALEMAELT 425
>gi|34328899 protein tyrosine phosphatase, non-receptor type 14
[Homo sapiens]
Length = 1187
Score = 133 bits (334), Expect = 1e-30
Identities = 89/290 (30%), Positives = 140/290 (48%), Gaps = 24/290 (8%)
Query: 221 KVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIK 280
++ LLD C L + GQ + V + L L E YFGL F +Q W++ K +K
Sbjct: 24 RIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLK 83
Query: 281 RQL---RNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLG 337
+ L N P LF F V FY P+ S L ++ TRY LQ+++D+ GRL C+ L
Sbjct: 84 KHLDKFANEPLLF-FGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLA 142
Query: 338 SYTLQAELGDYDPEEHGSIDLSEFQFAPTQT-------KELEEKVAELHKTHRGLSPAQA 390
+QA+ GDY+ + L E+ P +EL +KVA+ HK H G+ PA+A
Sbjct: 143 GLAVQADFGDYNQFDSQDF-LREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPAEA 201
Query: 391 DSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINR----FAWPKIL 446
+ ++ +RL +G ++ KD+ G + LG+ G+ + R RI R + W +
Sbjct: 202 ELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFV---RNRIGRQAVIYRWNDMG 258
Query: 447 KISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYR 496
I++ +S + EL E T F + AK + ++ H FY+
Sbjct: 259 NITHNKSTILV-----ELINKEETALFHTDDIENAKYISRLFATRHKFYK 303
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 131 bits (329), Expect = 4e-30
Identities = 92/294 (31%), Positives = 149/294 (50%), Gaps = 19/294 (6%)
Query: 216 KTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDP 275
K + +VT +D E ++ + G+ LFD+V + + L E +FGL + +S WL
Sbjct: 3 KPINVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61
Query: 276 AKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVT 332
K++ +Q + P F F KF+P D S+ L ++IT+ LQ+++ I + + C T
Sbjct: 62 NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121
Query: 333 HALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQ-------TKEL-EEKVAELHKTHRG 384
LL SY +QA+ GDY+ E H L+ + P + TKE EE++ H+ HRG
Sbjct: 122 AVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRG 181
Query: 385 LSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFA 441
+ + ++L+ A+ L MYGV+ K+ +G ++ LGV A GL IY+ ++ F
Sbjct: 182 MLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241
Query: 442 WPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495
W +I IS+ F IK + F F P R KR+ +C+ +H Y
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNHELY 291
Score = 40.8 bits (94), Expect = 0.006
Identities = 49/228 (21%), Positives = 95/228 (41%), Gaps = 36/228 (15%)
Query: 8 VSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEE------EKGSQPPPAAESQSSLRR 61
++E +K+ + + E+ K++ E + EE E + A E L +
Sbjct: 332 IAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEK 391
Query: 62 QKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEE 121
++R E ++S I++ +K Q+ +A+ A++EE KEE E
Sbjct: 392 ERRAAEEAKS-AIAKQAADQMKNQEQLAAELAEFTAKI-----ALLEEAKKKKEEEATEW 445
Query: 122 QRQAKGDAEEMAQKKQEIKVEVKEEKPSV-------------SKEEKPSVSKVEMQPTEL 168
Q +A E++ + K+E+K + P +E + + E+ +
Sbjct: 446 QHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGV 505
Query: 169 VS-KEREEKVKETQEDK----------LEGGAAKRETKEVQTNELKAE 205
++ + EE+V ETQ+++ E A+ ETK+ Q + L AE
Sbjct: 506 MNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAE 553
Score = 37.7 bits (86), Expect = 0.055
Identities = 43/195 (22%), Positives = 82/195 (42%), Gaps = 22/195 (11%)
Query: 24 KEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPPWLK 83
+ KP + E QQ ++ EE+ Q A +R+ EKE ++
Sbjct: 294 RRKPDTI-EVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKER-----------IE 341
Query: 84 KQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIKVEV 143
++K + K ++ Q +EEQ K L +E+++AK +AE + ++++
Sbjct: 342 REKEELMERLKQIEEQTIKAQKELEEQT-RKALELDQERKRAKEEAERLEKERR----AA 396
Query: 144 KEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQEDKLEGGAAKRETKEVQTNELK 203
+E K +++K+ + E EL + + E + K E E E Q
Sbjct: 397 EEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKE-----EEATEWQHKAFA 451
Query: 204 AEKASQKVTKKTKTV 218
A++ +K ++ KTV
Sbjct: 452 AQEDLEKTKEELKTV 466
Score = 32.0 bits (71), Expect = 3.0
Identities = 39/207 (18%), Positives = 79/207 (38%), Gaps = 15/207 (7%)
Query: 18 LGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRF 77
L D +++ KE AE + + EE K + AA+ + +++ E +E
Sbjct: 373 LELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKN--QEQLAAELAEFTAKIAL 430
Query: 78 IPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEE--QVLDKEEPLP----------EEQRQA 125
+ KK++ +E + EE V+ P P E
Sbjct: 431 LEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHD 490
Query: 126 KGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQEDKL 185
+ +AE A+ E + + E+ V++ +K K ++Q + ++ K+TQ D L
Sbjct: 491 ENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVL 550
Query: 186 EGGAAKRETKEVQT-NELKAEKASQKV 211
K + +T +++ Q++
Sbjct: 551 HAENVKAGRDKYKTLRQIRQGNTKQRI 577
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 128 bits (322), Expect = 2e-29
Identities = 89/298 (29%), Positives = 150/298 (50%), Gaps = 22/298 (7%)
Query: 213 KKTKTVQCKVTLLDGT-EYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKN 271
K+ KT ++ +D E++C+++ KG+ LFD VC L L E +FGL + +
Sbjct: 17 KQPKTFTVRIVTMDAEMEFNCEMKW--KGKDLFDLVCRTLGLRETWFFGLQYTIK-DTVA 73
Query: 272 WLDPAKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPC 328
WL K++ + P F F KFYP + + L ++IT++ LQ+++ I ++ C
Sbjct: 74 WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 133
Query: 329 SFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL--------EEKVAELHK 380
LL SY +QA+ GDYDP H L++ + P + L EE++ +
Sbjct: 134 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYA 193
Query: 381 THRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN-- 438
HRG + +A+ ++L+ A+ L MYGV+ ++ +G ++ LGV A GL IY R+
Sbjct: 194 EHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPK 253
Query: 439 -RFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495
F W +I ISY F IK +++ F+ F R K + ++C+ +H +
Sbjct: 254 ISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 307
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.127 0.349
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,461,529
Number of Sequences: 37866
Number of extensions: 2023399
Number of successful extensions: 22869
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 287
Number of HSP's successfully gapped in prelim test: 1012
Number of HSP's that attempted gapping in prelim test: 11722
Number of HSP's gapped (non-prelim): 7344
length of query: 1005
length of database: 18,247,518
effective HSP length: 112
effective length of query: 893
effective length of database: 14,006,526
effective search space: 12507827718
effective search space used: 12507827718
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.