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Search of human proteins with 4503513
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503513 eukaryotic translation initiation factor 3, subunit
2 beta, 36kDa [Homo sapiens]
(325 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503513 eukaryotic translation initiation factor 3, subunit 2... 677 0.0
gi|148727341 serine/threonine kinase receptor associated protein... 99 5e-21
gi|32189425 WD repeat domain 69 [Homo sapiens] 91 2e-18
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 79 5e-15
gi|23199987 WD repeat domain 5B [Homo sapiens] 74 2e-13
gi|239753142 PREDICTED: similar to unr-interacting protein [Homo... 73 3e-13
gi|239747708 PREDICTED: similar to unr-interacting protein [Homo... 73 3e-13
gi|113412837 PREDICTED: similar to unr-interacting protein [Homo... 71 1e-12
gi|16554629 WD repeat domain 5 [Homo sapiens] 70 2e-12
gi|16554627 WD repeat domain 5 [Homo sapiens] 70 2e-12
gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog... 69 4e-12
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 67 2e-11
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 67 2e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 65 6e-11
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 65 1e-10
gi|153791630 bromodomain and WD repeat domain containing 3 [Homo... 65 1e-10
gi|26665869 WD repeat domain 51B [Homo sapiens] 64 2e-10
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 63 3e-10
gi|16445438 bromodomain and WD repeat domain containing 1 isofor... 63 4e-10
gi|16445436 bromodomain and WD repeat domain containing 1 isofor... 63 4e-10
gi|34996489 pleckstrin homology domain interacting protein [Homo... 62 7e-10
gi|19913367 transducin beta-like 1Y [Homo sapiens] 62 9e-10
gi|19913365 transducin beta-like 1Y [Homo sapiens] 62 9e-10
gi|15150805 transducin beta-like 1Y [Homo sapiens] 62 9e-10
gi|13376840 WD repeat domain 61 [Homo sapiens] 62 9e-10
gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens] 62 9e-10
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 61 1e-09
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 61 1e-09
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 61 1e-09
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 61 2e-09
>gi|4503513 eukaryotic translation initiation factor 3, subunit 2
beta, 36kDa [Homo sapiens]
Length = 325
Score = 677 bits (1748), Expect = 0.0
Identities = 325/325 (100%), Positives = 325/325 (100%)
Query: 1 MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDA 60
MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDA
Sbjct: 1 MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDA 60
Query: 61 DWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQC 120
DWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQC
Sbjct: 61 DWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQC 120
Query: 121 FVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEV 180
FVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEV
Sbjct: 121 FVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEV 180
Query: 181 LVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPN 240
LVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPN
Sbjct: 181 LVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPN 240
Query: 241 YDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSY 300
YDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSY
Sbjct: 241 YDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSY 300
Query: 301 SSGGEDGYVRIHYFDPQYFEFEFEA 325
SSGGEDGYVRIHYFDPQYFEFEFEA
Sbjct: 301 SSGGEDGYVRIHYFDPQYFEFEFEA 325
>gi|148727341 serine/threonine kinase receptor associated protein
[Homo sapiens]
Length = 350
Score = 99.0 bits (245), Expect = 5e-21
Identities = 79/322 (24%), Positives = 134/322 (41%), Gaps = 50/322 (15%)
Query: 3 PILLQGHERSITQIKYNR---EGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVD 59
P+ GH R + + ++ G L + KD + G+ +GT++GH GAVW
Sbjct: 7 PLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGAT 66
Query: 60 ADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQ 119
+ D T +AD + ++WD +G +L L V+T F N ++ G
Sbjct: 67 LNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTG-----GQD 121
Query: 120 CFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGE 179
+ +DL P EP +I + S I A+W + I++ +
Sbjct: 122 KLLRIYDLNKPEA----EP-KEISGHTSGIKKALWCSEDKQILSADDK------------ 164
Query: 180 VLVNVKEHSRQINDIQLSRDMTM----------FVTASKDNTAKLFDSTTLEHQKTFRTE 229
V + +H+ L+ +M++ + + + + +L+ K+F
Sbjct: 165 -TVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAP 223
Query: 230 RPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPIN 289
+NSA+L P + +V GG F+ + EE KGHFGPI+
Sbjct: 224 ATINSASLHPEKEFLVAGGED--------------FKLYKYDYNSGEELESYKGHFGPIH 269
Query: 290 SVAFHPDGKSYSSGGEDGYVRI 311
V F PDG+ Y+SG EDG +R+
Sbjct: 270 CVRFSPDGELYASGSEDGTLRL 291
Score = 62.4 bits (150), Expect = 5e-10
Identities = 51/220 (23%), Positives = 99/220 (45%), Gaps = 25/220 (11%)
Query: 4 ILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGT--YMGHTG----AVWC 57
++ H+ + + + ++ + L T +D ++ + Y +N GHT A+WC
Sbjct: 94 LMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRI-YDLNKPEAEPKEISGHTSGIKKALWC 152
Query: 58 VDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMG 117
+ K +L+ D + RLWD T ++ L N +V + + G I++ + + +
Sbjct: 153 SE----DKQILSAD-DKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIA 207
Query: 118 YQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKS 177
+ VS ++ + P I SA P E ++AG E +L +Y S
Sbjct: 208 FHSAVSLDPIKS----------FEAPAT---INSASLHPEKEFLVAGGEDFKLYKYDYNS 254
Query: 178 GEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDS 217
GE L + K H I+ ++ S D ++ + S+D T +L+ +
Sbjct: 255 GEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQT 294
Score = 40.4 bits (93), Expect = 0.002
Identities = 20/51 (39%), Positives = 26/51 (50%)
Query: 41 NGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLK 91
+GE L +Y GH G + CV D + +GS D + RLW GK L K
Sbjct: 254 SGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWK 304
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 90.5 bits (223), Expect = 2e-18
Identities = 75/309 (24%), Positives = 130/309 (42%), Gaps = 26/309 (8%)
Query: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCV--DADW 62
+L+ H +T + N+ G T + D +W + +GE L T GH V+ + + +
Sbjct: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146
Query: 63 DTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFV 122
K + TGS D +C+LW ETGK + ++A I+ S + Q
Sbjct: 147 GDK-IATGSFDKTCKLWSVETGKCYHTFRGHTA----------EIVCLSFNPQSTLVATG 195
Query: 123 SFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLV 182
S I N E + + ++I S + G+ II G + + A +G +
Sbjct: 196 SMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN 255
Query: 183 NVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYD 242
+ H +I+ + D ++ +T S D T KL+D+T + K T + L +D
Sbjct: 256 ILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDAT---NGKCVATLTGHDDEILDSCFD 312
Query: 243 HVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSS 302
+ G+ + T AR F A + +++GH G I+ ++F+P G +
Sbjct: 313 YT----GKLIATASADGT------ARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLT 362
Query: 303 GGEDGYVRI 311
G D RI
Sbjct: 363 GSSDKTARI 371
Score = 85.9 bits (211), Expect = 4e-17
Identities = 54/212 (25%), Positives = 100/212 (47%), Gaps = 14/212 (6%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65
L+GH I + +N GD + T + D V VW + G ++ +GH + +WD
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274
Query: 66 HVLTGSADNSCRLWDCETGKQLALL--KTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVS 123
+LTGS D +C+LWD GK +A L + + +C FD+ G +I +T G S
Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC-FDYTGKLI--ATASADGTARIFS 331
Query: 124 FFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVN 183
+ ++++ +E +I+ + P G ++ G + A++G+ L
Sbjct: 332 AATRKCIAKLEGHE---------GEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382
Query: 184 VKEHSRQINDIQLSRDMTMFVTASKDNTAKLF 215
++ H+ +I + + +T SKDNT +++
Sbjct: 383 LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 75.9 bits (185), Expect = 5e-14
Identities = 70/309 (22%), Positives = 131/309 (42%), Gaps = 28/309 (9%)
Query: 6 LQGHERSITQIKYNRE-GDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64
L+GH + I +N GD + T + D +W G+ T+ GHT + C+ + +
Sbjct: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQS 189
Query: 65 KHVLTGSADNSCRLWDCETGKQLALLKTNSA-VRTCGFDFGGNIIMFSTDKQMGYQCFVS 123
V TGS D + +LWD + G+++ L+ +SA + + F+ G+ I+ + + V
Sbjct: 190 TLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGS-----FDHTVV 244
Query: 124 FFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVN 183
+D D + + ++I+SA + I+ G + A +G+ +
Sbjct: 245 VWD------ADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVAT 298
Query: 184 VKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLE-HQKTFRTERPVNSAALSPNYD 242
+ H +I D + TAS D TA++F + T + K E ++ + +P +
Sbjct: 299 LTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358
Query: 243 HVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSS 302
H++ G + AR + + ++GH I S AF+ G +
Sbjct: 359 HLLTGSSDKT--------------ARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVIT 404
Query: 303 GGEDGYVRI 311
G +D RI
Sbjct: 405 GSKDNTCRI 413
Score = 37.0 bits (84), Expect = 0.024
Identities = 33/140 (23%), Positives = 58/140 (41%), Gaps = 16/140 (11%)
Query: 169 ELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRT 228
+L Q S + + +K H + ++ L++ + F+T S D T KL+D+ + E T
Sbjct: 73 KLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEG 132
Query: 229 ERPVNSAAL--SPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFG 286
R V A +P D + G + + + T GK F +GH
Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVET--GKCYHTF------------RGHTA 178
Query: 287 PINSVAFHPDGKSYSSGGED 306
I ++F+P ++G D
Sbjct: 179 EIVCLSFNPQSTLVATGSMD 198
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 79.0 bits (193), Expect = 5e-15
Identities = 71/317 (22%), Positives = 134/317 (42%), Gaps = 42/317 (13%)
Query: 4 ILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGE--RLGTYMGHTGAVWCVDAD 61
+LL GHE + K++ G L + D ++ +W +V G+ T GH+GAV + +
Sbjct: 60 MLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLW-NVYGDCDNYATLKGHSGAVMELHYN 118
Query: 62 WDTKHVLTGSADNSCRLWDCETGKQLALLKTN-SAVRTC-GFDFGGNIIMFSTDKQMGYQ 119
D + + S D + +WD ETG+++ LK + S V +C G ++ +D
Sbjct: 119 TDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT--- 175
Query: 120 CFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGE 179
V +D+R + I + N ++ + + + II+G ++ + + +
Sbjct: 176 --VKLWDIRKKAAIQTFQ-------NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNK 226
Query: 180 VLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFD---------STTLEHQKTFRTER 230
+ ++ H+ + + LS + + ++ + DNT +++D + E+
Sbjct: 227 LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEK 286
Query: 231 PVNSAALSPNYDHVVLGGGQEAMDV-TTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPIN 289
+ + SP+ + G + V TTS RI ++ GH G IN
Sbjct: 287 NLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRI---------------LYKLPGHAGSIN 331
Query: 290 SVAFHPDGKSYSSGGED 306
VAFHPD S D
Sbjct: 332 EVAFHPDEPIIISASSD 348
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 73.9 bits (180), Expect = 2e-13
Identities = 64/295 (21%), Positives = 131/295 (44%), Gaps = 29/295 (9%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65
L GH +++ +K++ G+ L + + D ++ +W + +G+ T GH + V D+
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
Query: 66 HVLTGSADNSCRLWDCETGKQLALLKTNS-AVRTCGFDFGGNIIMFSTDKQMGYQCFVSF 124
+++ S D + +LWD +GK L LK +S V C F+ N+I+ SF
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISG-----------SF 145
Query: 125 FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVN- 183
+ ++ + + + +++ + G I++G G + A SG+ L
Sbjct: 146 DETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL 205
Query: 184 VKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTF---RTERPVNSAALSPN 240
V + + ++ ++ S + +TA+ DNT KL+D + KT+ + E+ A S
Sbjct: 206 VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVT 265
Query: 241 YDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHP 295
++ G ++ + ++L +E +++GH + S A HP
Sbjct: 266 GGKWIVSGSEDNL-------------VYIWNLQTKEIVQKLQGHTDVVISAACHP 307
Score = 60.1 bits (144), Expect = 3e-09
Identities = 60/254 (23%), Positives = 113/254 (44%), Gaps = 40/254 (15%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65
L GH I+ + ++ + L + + D + +W +G+ L T GH+ V+C + + +
Sbjct: 79 LYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSN 138
Query: 66 HVLTGSADNSCRLWDCETGKQLALLKTNS-AVRTCGFDFGGNIIMFST--------DKQM 116
+++GS D + ++W+ +TGK L L +S V F+ G++I+ + D
Sbjct: 139 LIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAAS 198
Query: 117 GYQCFVSFFDLRDPSQIDNNEP--YMKIPCNDSKITSA-------VWG-PLGECI--IAG 164
G QC + D D+N P ++K N I +A +W G C+ G
Sbjct: 199 G-QCLKTLVD-------DDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG 250
Query: 165 HESGE---LNQYSAKSGEVLVNVKEH------SRQINDI--QLSRDMTMFVTASKDNTAK 213
H++ + +S G+ +V+ E + Q +I +L + ++A+ T
Sbjct: 251 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN 310
Query: 214 LFDSTTLEHQKTFR 227
L S LE+ KT +
Sbjct: 311 LIASAALENDKTIK 324
Score = 44.3 bits (103), Expect = 1e-04
Identities = 39/164 (23%), Positives = 69/164 (42%), Gaps = 15/164 (9%)
Query: 149 ITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASK 208
++S + P GE + + + + A G+ + H+ +I+D+ S D + V+AS
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103
Query: 209 DNTAKLFDSTTLEHQKTFRTERP-VNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEA 267
D T KL+D + + KT + V +P + ++ G E + + T GK
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT--GKC-- 159
Query: 268 RFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311
+ H P+++V F+ G SG DG RI
Sbjct: 160 ----------LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRI 193
>gi|239753142 PREDICTED: similar to unr-interacting protein [Homo
sapiens]
Length = 347
Score = 73.2 bits (178), Expect = 3e-13
Identities = 67/276 (24%), Positives = 112/276 (40%), Gaps = 42/276 (15%)
Query: 42 GERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGF 101
G+ +GT+ GH GAVW A + T +AD + ++WD G +L L V+T F
Sbjct: 49 GDWIGTFWGHKGAVW--GATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYF 106
Query: 102 DFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECI 161
N ++ G + +DL P +I + S I +W + I
Sbjct: 107 MQDSNYLLTK-----GQDKLLRMYDLNKPKARPK-----EISGHTSGIKKGLWCSEDKQI 156
Query: 162 IAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASK------DNTAKLF 215
++ + A EV + +N +S T ++ + +
Sbjct: 157 LSADDKTARLWDHATMTEV--------KSLN-FNMSVSSTKYIPEGEILVITYGLSIAFH 207
Query: 216 DSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFE 275
+ +L+ +F +NSA+L P + +V GG + + +
Sbjct: 208 SAVSLDPITSFEAPATINSASLHPEKEFLVAGGEDFKL---------------YKYFNHG 252
Query: 276 EEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311
EEF KG+FGPI+ V F DG+ Y+SG EDG +R+
Sbjct: 253 EEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRL 288
Score = 50.4 bits (119), Expect = 2e-06
Identities = 52/217 (23%), Positives = 97/217 (44%), Gaps = 26/217 (11%)
Query: 4 ILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGE--RLGTYMGHTGAV----WC 57
++ H+ + + + ++ + L T +D ++ + Y +N R GHT + WC
Sbjct: 92 LMTLAHKYIVKTVYFMQDSNYLLTKGQDKLLRM-YDLNKPKARPKEISGHTSGIKKGLWC 150
Query: 58 VDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMG 117
+ K +L+ D + RLWD T ++ L N +V + + G I++ + +
Sbjct: 151 SE----DKQILSAD-DKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIA 205
Query: 118 YQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKS 177
+ VS DP I + E + I SA P E ++AG E +L +Y
Sbjct: 206 FHSAVSL----DP--ITSFEA-------PATINSASLHPEKEFLVAGGEDFKLYKYF-NH 251
Query: 178 GEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKL 214
GE + K + I+ ++ SRD ++ + S+D T +L
Sbjct: 252 GEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRL 288
Score = 32.7 bits (73), Expect = 0.45
Identities = 18/54 (33%), Positives = 25/54 (46%)
Query: 38 YSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLK 91
Y +GE +Y G+ G + CV D + +GS D + RL GK L K
Sbjct: 248 YFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTYGLWK 301
>gi|239747708 PREDICTED: similar to unr-interacting protein [Homo
sapiens]
Length = 347
Score = 73.2 bits (178), Expect = 3e-13
Identities = 67/276 (24%), Positives = 112/276 (40%), Gaps = 42/276 (15%)
Query: 42 GERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGF 101
G+ +GT+ GH GAVW A + T +AD + ++WD G +L L V+T F
Sbjct: 49 GDWIGTFWGHKGAVW--GATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYF 106
Query: 102 DFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECI 161
N ++ G + +DL P +I + S I +W + I
Sbjct: 107 MQDSNYLLTK-----GQDKLLRMYDLNKPKARPK-----EISGHTSGIKKGLWCSEDKQI 156
Query: 162 IAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASK------DNTAKLF 215
++ + A EV + +N +S T ++ + +
Sbjct: 157 LSADDKTARLWDHATMTEV--------KSLN-FNMSVSSTKYIPEGEILVITYGLSIAFH 207
Query: 216 DSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFE 275
+ +L+ +F +NSA+L P + +V GG + + +
Sbjct: 208 SAVSLDPITSFEAPATINSASLHPEKEFLVAGGEDFKL---------------YKYFNHG 252
Query: 276 EEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311
EEF KG+FGPI+ V F DG+ Y+SG EDG +R+
Sbjct: 253 EEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRL 288
Score = 50.4 bits (119), Expect = 2e-06
Identities = 52/217 (23%), Positives = 97/217 (44%), Gaps = 26/217 (11%)
Query: 4 ILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGE--RLGTYMGHTGAV----WC 57
++ H+ + + + ++ + L T +D ++ + Y +N R GHT + WC
Sbjct: 92 LMTLAHKYIVKTVYFMQDSNYLLTKGQDKLLRM-YDLNKPKARPKEISGHTSGIKKGLWC 150
Query: 58 VDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMG 117
+ K +L+ D + RLWD T ++ L N +V + + G I++ + +
Sbjct: 151 SE----DKQILSAD-DKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIA 205
Query: 118 YQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKS 177
+ VS DP I + E + I SA P E ++AG E +L +Y
Sbjct: 206 FHSAVSL----DP--ITSFEA-------PATINSASLHPEKEFLVAGGEDFKLYKYF-NH 251
Query: 178 GEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKL 214
GE + K + I+ ++ SRD ++ + S+D T +L
Sbjct: 252 GEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRL 288
Score = 32.7 bits (73), Expect = 0.45
Identities = 18/54 (33%), Positives = 25/54 (46%)
Query: 38 YSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLK 91
Y +GE +Y G+ G + CV D + +GS D + RL GK L K
Sbjct: 248 YFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTYGLWK 301
>gi|113412837 PREDICTED: similar to unr-interacting protein [Homo
sapiens]
Length = 348
Score = 70.9 bits (172), Expect = 1e-12
Identities = 66/276 (23%), Positives = 110/276 (39%), Gaps = 41/276 (14%)
Query: 42 GERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGF 101
G+ +GT+ GH GAVW A + T +AD + ++WD G +L L V+T F
Sbjct: 49 GDWIGTFWGHKGAVW--GATLNATKAATAAADFTAKVWDAVLGDELMTLAHKYIVKTVYF 106
Query: 102 DFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECI 161
N ++ G + +DL P P S TS + L C
Sbjct: 107 MQDSNYLLTK-----GQDKLLRMYDLNKPKAR---------PKEISGHTSGIKKRLLWC- 151
Query: 162 IAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASK------DNTAKLF 215
E ++ K+ + + + + +S T ++ + +
Sbjct: 152 ---SEDKQILSADDKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSIAFH 208
Query: 216 DSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFE 275
+ +L+ +F +NSA+L P + +V GG + + +
Sbjct: 209 SAVSLDPITSFEAPATINSASLHPEKEFLVAGGEDFKL---------------YKYFNHG 253
Query: 276 EEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311
EEF KG+FGPI+ V F DG+ Y+SG EDG +R+
Sbjct: 254 EEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRL 289
Score = 50.1 bits (118), Expect = 3e-06
Identities = 52/218 (23%), Positives = 97/218 (44%), Gaps = 27/218 (12%)
Query: 4 ILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGE--RLGTYMGHTGAV-----W 56
++ H+ + + + ++ + L T +D ++ + Y +N R GHT + W
Sbjct: 92 LMTLAHKYIVKTVYFMQDSNYLLTKGQDKLLRM-YDLNKPKARPKEISGHTSGIKKRLLW 150
Query: 57 CVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQM 116
C + K +L+ D + RLWD T ++ L N +V + + G I++ + +
Sbjct: 151 CSE----DKQILSAD-DKTARLWDHATMTEVKSLNFNMSVSSTKYIPEGEILVITYGLSI 205
Query: 117 GYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAK 176
+ VS DP I + E + I SA P E ++AG E +L +Y
Sbjct: 206 AFHSAVSL----DP--ITSFEA-------PATINSASLHPEKEFLVAGGEDFKLYKYF-N 251
Query: 177 SGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKL 214
GE + K + I+ ++ SRD ++ + S+D T +L
Sbjct: 252 HGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRL 289
Score = 32.7 bits (73), Expect = 0.45
Identities = 18/54 (33%), Positives = 25/54 (46%)
Query: 38 YSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLK 91
Y +GE +Y G+ G + CV D + +GS D + RL GK L K
Sbjct: 249 YFNHGEEFESYKGYFGPIHCVRFSRDGELYASGSEDGTLRLGQTVVGKTYGLWK 302
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 70.5 bits (171), Expect = 2e-12
Identities = 60/295 (20%), Positives = 133/295 (45%), Gaps = 29/295 (9%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65
L GH ++++ +K++ G+ L + + D ++ +W + +G+ T GH + V D+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 66 HVLTGSADNSCRLWDCETGKQLALLKTNS-AVRTCGFDFGGNIIMFSTDKQMGYQCFVSF 124
+++ S D + ++WD +GK L LK +S V C F+ N+I+ + + V
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS-----FDESVRI 155
Query: 125 FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVN- 183
+D++ + +P + +++ + G I++ G + SG+ L
Sbjct: 156 WDVK------TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209
Query: 184 VKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTF---RTERPVNSAALSPN 240
+ + + ++ ++ S + + A+ DNT KL+D + + KT+ + E+ A S
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Query: 241 YDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHP 295
++ G ++ + ++L +E +++GH + S A HP
Sbjct: 270 GGKWIVSGSEDNL-------------VYIWNLQTKEIVQKLQGHTDVVISTACHP 311
Score = 48.1 bits (113), Expect = 1e-05
Identities = 44/203 (21%), Positives = 90/203 (44%), Gaps = 16/203 (7%)
Query: 47 TYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGN 106
T GHT AV V + + + + SAD ++W GK KT S G G +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK---FEKTIS-----GHKLGIS 91
Query: 107 IIMFSTDKQMGYQCFVSFFDLRDPS--QIDNNEPYMKIPCNDSKITSAVWGPLGECIIAG 164
+ +S+D + VS D + + + + + + + + + P I++G
Sbjct: 92 DVAWSSDSNL----LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147
Query: 165 HESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQK 224
+ + K+G+ L + HS ++ + +RD ++ V++S D +++D+ + + K
Sbjct: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 225 TFRTE--RPVNSAALSPNYDHVV 245
T + PV+ SPN +++
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYIL 230
Score = 47.0 bits (110), Expect = 2e-05
Identities = 39/164 (23%), Positives = 69/164 (42%), Gaps = 15/164 (9%)
Query: 149 ITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASK 208
++S + P GE + + + + A G+ + H I+D+ S D + V+AS
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 209 DNTAKLFDSTTLEHQKTFRTERP-VNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEA 267
D T K++D ++ + KT + V +P + +V G E++ + T GK
Sbjct: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT--GKC-- 163
Query: 268 RFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311
+ H P+++V F+ DG S DG RI
Sbjct: 164 ----------LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197
Score = 43.1 bits (100), Expect = 3e-04
Identities = 22/95 (23%), Positives = 47/95 (49%), Gaps = 3/95 (3%)
Query: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64
L+ ++ +K++ G + D + +W G+ L TY GH +C+ A++
Sbjct: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268
Query: 65 ---KHVLTGSADNSCRLWDCETGKQLALLKTNSAV 96
K +++GS DN +W+ +T + + L+ ++ V
Sbjct: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 70.5 bits (171), Expect = 2e-12
Identities = 60/295 (20%), Positives = 133/295 (45%), Gaps = 29/295 (9%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65
L GH ++++ +K++ G+ L + + D ++ +W + +G+ T GH + V D+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 66 HVLTGSADNSCRLWDCETGKQLALLKTNS-AVRTCGFDFGGNIIMFSTDKQMGYQCFVSF 124
+++ S D + ++WD +GK L LK +S V C F+ N+I+ + + V
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS-----FDESVRI 155
Query: 125 FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVN- 183
+D++ + +P + +++ + G I++ G + SG+ L
Sbjct: 156 WDVK------TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209
Query: 184 VKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTF---RTERPVNSAALSPN 240
+ + + ++ ++ S + + A+ DNT KL+D + + KT+ + E+ A S
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Query: 241 YDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHP 295
++ G ++ + ++L +E +++GH + S A HP
Sbjct: 270 GGKWIVSGSEDNL-------------VYIWNLQTKEIVQKLQGHTDVVISTACHP 311
Score = 48.1 bits (113), Expect = 1e-05
Identities = 44/203 (21%), Positives = 90/203 (44%), Gaps = 16/203 (7%)
Query: 47 TYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGN 106
T GHT AV V + + + + SAD ++W GK KT S G G +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK---FEKTIS-----GHKLGIS 91
Query: 107 IIMFSTDKQMGYQCFVSFFDLRDPS--QIDNNEPYMKIPCNDSKITSAVWGPLGECIIAG 164
+ +S+D + VS D + + + + + + + + + P I++G
Sbjct: 92 DVAWSSDSNL----LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147
Query: 165 HESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQK 224
+ + K+G+ L + HS ++ + +RD ++ V++S D +++D+ + + K
Sbjct: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 225 TFRTE--RPVNSAALSPNYDHVV 245
T + PV+ SPN +++
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYIL 230
Score = 47.0 bits (110), Expect = 2e-05
Identities = 39/164 (23%), Positives = 69/164 (42%), Gaps = 15/164 (9%)
Query: 149 ITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASK 208
++S + P GE + + + + A G+ + H I+D+ S D + V+AS
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 209 DNTAKLFDSTTLEHQKTFRTERP-VNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEA 267
D T K++D ++ + KT + V +P + +V G E++ + T GK
Sbjct: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT--GKC-- 163
Query: 268 RFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311
+ H P+++V F+ DG S DG RI
Sbjct: 164 ----------LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197
Score = 43.1 bits (100), Expect = 3e-04
Identities = 22/95 (23%), Positives = 47/95 (49%), Gaps = 3/95 (3%)
Query: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64
L+ ++ +K++ G + D + +W G+ L TY GH +C+ A++
Sbjct: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268
Query: 65 ---KHVLTGSADNSCRLWDCETGKQLALLKTNSAV 96
K +++GS DN +W+ +T + + L+ ++ V
Sbjct: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303
>gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog
[Homo sapiens]
Length = 518
Score = 69.3 bits (168), Expect = 4e-12
Identities = 56/230 (24%), Positives = 101/230 (43%), Gaps = 10/230 (4%)
Query: 18 YNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCR 77
+ ++G LL ++D V ++ L + GHT AV VD D HV++G+ D + +
Sbjct: 88 FRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVK 147
Query: 78 LWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNE 137
LWD K++ K +S CG N +F T Y V FD R + + E
Sbjct: 148 LWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITG---SYDHTVKMFDARTSESVLSVE 204
Query: 138 PYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLS 197
+ + S + P G +++ K G++LV++K H + + + LS
Sbjct: 205 -------HGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLS 257
Query: 198 RDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLG 247
++ S D K++ +T+ + +F + S AL+ + +V+G
Sbjct: 258 SSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALAHEDETIVVG 307
Score = 41.2 bits (95), Expect = 0.001
Identities = 24/91 (26%), Positives = 47/91 (51%), Gaps = 1/91 (1%)
Query: 161 IIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSR-DMTMFVTASKDNTAKLFDSTT 219
+++G + + + + + ++ KEHS + S+ + +F+T S D+T K+FD+ T
Sbjct: 137 VVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDART 196
Query: 220 LEHQKTFRTERPVNSAALSPNYDHVVLGGGQ 250
E + +PV S L P+ +V GG+
Sbjct: 197 SESVLSVEHGQPVESVLLFPSGGLLVSAGGR 227
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 67.4 bits (163), Expect = 2e-11
Identities = 67/310 (21%), Positives = 123/310 (39%), Gaps = 33/310 (10%)
Query: 7 QGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKH 66
+GH ++T + ++ L + + D + VW+ R + GH AV CV+
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 67 VLTGSADNSCRLWDCETGKQLALLKTNSA-VRTCGF-DFGGNIIMFSTDKQMGYQCFVSF 124
+ +GS D + R+W + + + ++A VR+ F G + + S DK +
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135
Query: 125 FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNV 184
L SQ N + A + P G I++ + + + S E + +
Sbjct: 136 KFLFSLSQHIN------------WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
Query: 185 KEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTT---LEHQKTFRTERPVNSAALSPNY 241
EH + + T A DNT K++D T L+H + VN + P+
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAA--VNGLSFHPSG 241
Query: 242 DHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYS 301
++++ + + + E R + + GH GP +VAF G+ ++
Sbjct: 242 NYLITASSDSTLKI------LDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFA 287
Query: 302 SGGEDGYVRI 311
SGG D V +
Sbjct: 288 SGGSDEQVMV 297
Score = 41.6 bits (96), Expect = 0.001
Identities = 30/113 (26%), Positives = 51/113 (45%), Gaps = 2/113 (1%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65
L H + K++ +G L+ + + D V +W + E + +Y H G V VD
Sbjct: 141 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 200
Query: 66 HVLTGSADNSCRLWDCETGKQLALLKTNS-AVRTCGFDFGGN-IIMFSTDKQM 116
+ DN+ ++WD T + L + +S AV F GN +I S+D +
Sbjct: 201 CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253
Score = 32.7 bits (73), Expect = 0.45
Identities = 16/73 (21%), Positives = 31/73 (42%)
Query: 7 QGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKH 66
Q H ++ + ++ G+ L T + D + + + G L T GH G V ++
Sbjct: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
Query: 67 VLTGSADNSCRLW 79
+G +D +W
Sbjct: 286 FASGGSDEQVMVW 298
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 67.4 bits (163), Expect = 2e-11
Identities = 67/310 (21%), Positives = 123/310 (39%), Gaps = 33/310 (10%)
Query: 7 QGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKH 66
+GH ++T + ++ L + + D + VW+ R + GH AV CV+
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 67 VLTGSADNSCRLWDCETGKQLALLKTNSA-VRTCGF-DFGGNIIMFSTDKQMGYQCFVSF 124
+ +GS D + R+W + + + ++A VR+ F G + + S DK +
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135
Query: 125 FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNV 184
L SQ N + A + P G I++ + + + S E + +
Sbjct: 136 KFLFSLSQHIN------------WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
Query: 185 KEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTT---LEHQKTFRTERPVNSAALSPNY 241
EH + + T A DNT K++D T L+H + VN + P+
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAA--VNGLSFHPSG 241
Query: 242 DHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYS 301
++++ + + + E R + + GH GP +VAF G+ ++
Sbjct: 242 NYLITASSDSTLKI------LDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFA 287
Query: 302 SGGEDGYVRI 311
SGG D V +
Sbjct: 288 SGGSDEQVMV 297
Score = 41.6 bits (96), Expect = 0.001
Identities = 30/113 (26%), Positives = 51/113 (45%), Gaps = 2/113 (1%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65
L H + K++ +G L+ + + D V +W + E + +Y H G V VD
Sbjct: 141 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 200
Query: 66 HVLTGSADNSCRLWDCETGKQLALLKTNS-AVRTCGFDFGGN-IIMFSTDKQM 116
+ DN+ ++WD T + L + +S AV F GN +I S+D +
Sbjct: 201 CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 253
Score = 32.7 bits (73), Expect = 0.45
Identities = 16/73 (21%), Positives = 31/73 (42%)
Query: 7 QGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKH 66
Q H ++ + ++ G+ L T + D + + + G L T GH G V ++
Sbjct: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
Query: 67 VLTGSADNSCRLW 79
+G +D +W
Sbjct: 286 FASGGSDEQVMVW 298
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 65.5 bits (158), Expect = 6e-11
Identities = 65/297 (21%), Positives = 111/297 (37%), Gaps = 68/297 (22%)
Query: 22 GDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDC 81
G LL T D VN+W + + GHT V V + + ++ GS S R+WD
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
Query: 82 ETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMK 141
E K L L MG++ + D
Sbjct: 93 EAAKILRTL-------------------------MGHKANICSLDFH------------- 114
Query: 142 IPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMT 201
P GE + +G + + + + + + HS+ + ++ S D
Sbjct: 115 --------------PYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGK 160
Query: 202 MFVTASKDNTAKLFDSTTLEHQKTFRTER-PVNSAALSPNYDHVVLGGGQEAMDVTTTST 260
+A+ D+T KL+D T + F PVN PN ++++ G +
Sbjct: 161 WLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPN-EYLLASGSSDRT------- 212
Query: 261 RIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQ 317
RF+ L + ++G GP+ SV F+PDG SG +D +R++ ++P+
Sbjct: 213 ------IRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS-LRVYGWEPE 262
Score = 48.5 bits (114), Expect = 8e-06
Identities = 22/76 (28%), Positives = 42/76 (55%)
Query: 7 QGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKH 66
+GH +++ ++++ +G L + A D V +W G+ + + GHTG V V+ +
Sbjct: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYL 203
Query: 67 VLTGSADNSCRLWDCE 82
+ +GS+D + R WD E
Sbjct: 204 LASGSSDRTIRFWDLE 219
Score = 47.0 bits (110), Expect = 2e-05
Identities = 47/205 (22%), Positives = 79/205 (38%), Gaps = 23/205 (11%)
Query: 117 GYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAK 176
G C V+ + + P+ I M + + S + S E I+AG +SG + + +
Sbjct: 40 GDDCRVNLWSINKPNCI------MSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLE 93
Query: 177 SGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTE-RPVNSA 235
+ ++L + H I + + S+D KL+D +R + V
Sbjct: 94 AAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCL 153
Query: 236 ALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHP 295
SP D L + V GK + F GH GP+N V FHP
Sbjct: 154 RFSP--DGKWLASAADDHTVKLWDLTAGKMMSEF------------PGHTGPVNVVEFHP 199
Query: 296 DGKSYSSGGEDGYVRIHYFDPQYFE 320
+ +SG D +R ++D + F+
Sbjct: 200 NEYLLASGSSDRTIR--FWDLEKFQ 222
Score = 39.3 bits (90), Expect = 0.005
Identities = 20/75 (26%), Positives = 35/75 (46%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65
L GH + ++ N +L+ ++ + VW + L T MGH + +D +
Sbjct: 59 LTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGE 118
Query: 66 HVLTGSADNSCRLWD 80
V +GS D + +LWD
Sbjct: 119 FVASGSQDTNIKLWD 133
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 64.7 bits (156), Expect = 1e-10
Identities = 59/251 (23%), Positives = 105/251 (41%), Gaps = 15/251 (5%)
Query: 8 GHERSITQIKYNREGDLLFTVAKDPIVNVWY-SVNGERLGTYMGHTGAVWCVDADWDTKH 66
GH+ ++T + ++ G LL + ++D V +W +V GE + HT V V D +
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSDGQS 79
Query: 67 VLTGSADNSCRLWDCETGKQLALLKTN-SAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFF 125
+T S D + ++W K L L + + VR F G +I+ ++D +
Sbjct: 80 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKT--------V 131
Query: 126 DLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVK 185
L D S + Y + + +T + P G CI A + + ++ +L + +
Sbjct: 132 KLWDKSSRECVHSYCE---HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQ 188
Query: 186 EHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTER-PVNSAALSPNYDHV 244
HS +N + +TAS D+T K+ D T + P + A S ++
Sbjct: 189 LHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYF 248
Query: 245 VLGGGQEAMDV 255
GG E + V
Sbjct: 249 ASGGSDEQVMV 259
Score = 60.8 bits (146), Expect = 2e-09
Identities = 63/286 (22%), Positives = 111/286 (38%), Gaps = 33/286 (11%)
Query: 31 DPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALL 90
D + VW+ R + GH AV CV+ + +GS D + R+W + +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 91 KTNSA-VRTCGF-DFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSK 148
+ ++A VR+ F G + + S DK + L SQ N
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHIN------------W 109
Query: 149 ITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASK 208
+ A + P G I++ + + + S E + + EH + + T A
Sbjct: 110 VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGM 169
Query: 209 DNTAKLFDSTT---LEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKF 265
DNT K++D T L+H + VN + P+ ++++ + + +
Sbjct: 170 DNTVKVWDVRTHRLLQHYQLHSAA--VNGLSFHPSGNYLITASSDSTLKI------LDLM 221
Query: 266 EARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311
E R + + GH GP +VAF G+ ++SGG D V +
Sbjct: 222 EGRLLYT--------LHGHQGPATTVAFSRTGEYFASGGSDEQVMV 259
Score = 41.6 bits (96), Expect = 0.001
Identities = 30/113 (26%), Positives = 51/113 (45%), Gaps = 2/113 (1%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65
L H + K++ +G L+ + + D V +W + E + +Y H G V VD
Sbjct: 103 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 162
Query: 66 HVLTGSADNSCRLWDCETGKQLALLKTNS-AVRTCGFDFGGN-IIMFSTDKQM 116
+ DN+ ++WD T + L + +S AV F GN +I S+D +
Sbjct: 163 CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 215
Score = 32.7 bits (73), Expect = 0.45
Identities = 16/73 (21%), Positives = 31/73 (42%)
Query: 7 QGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKH 66
Q H ++ + ++ G+ L T + D + + + G L T GH G V ++
Sbjct: 188 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 247
Query: 67 VLTGSADNSCRLW 79
+G +D +W
Sbjct: 248 FASGGSDEQVMVW 260
>gi|153791630 bromodomain and WD repeat domain containing 3 [Homo
sapiens]
Length = 1802
Score = 64.7 bits (156), Expect = 1e-10
Identities = 74/327 (22%), Positives = 136/327 (41%), Gaps = 27/327 (8%)
Query: 8 GHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHV 67
GH S+ + ++R G +FT + D +V +W + +G L T GH+ + + +++ +
Sbjct: 178 GHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLI 237
Query: 68 LTGSADNSCRLWDCETGKQLALLKTNSA----VRTCGFDFGGNIIMFSTDKQMGYQCFVS 123
GS D R+W T +A+L+ +SA ++ C G N + ST G CF
Sbjct: 238 AAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLTSTGAD-GTICFWQ 296
Query: 124 F------FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQY--SA 175
+ F R + + P ++I C S +S G I G + Y +
Sbjct: 297 WHVKTMKFRDRPVKFTERSRPGVQISC--SSFSSG-----GMFITTGSTDHVIRIYYLGS 349
Query: 176 KSGEVLVNVKEHSRQINDIQL--SRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVN 233
+ E + ++ H+ ++ +Q + D FV+ S+D TA+++ E +
Sbjct: 350 EVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKM 409
Query: 234 SAALSPNYDHVV--LGGGQEAMD--VTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPIN 289
+ P+ + + L A D TT T + F + ++ + + GH +
Sbjct: 410 TGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVF 469
Query: 290 SVAFHP-DGKSYSSGGEDGYVRIHYFD 315
+ HP D + S G DG + I D
Sbjct: 470 VLEAHPFDQRIILSAGHDGNIFIWDLD 496
Score = 43.9 bits (102), Expect = 2e-04
Identities = 25/101 (24%), Positives = 49/101 (48%), Gaps = 7/101 (6%)
Query: 13 ITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDA-DWDTKHVLTGS 71
+T + ++R + T + ++ VW S+ G+ L T GH V+ ++A +D + +L+
Sbjct: 426 VTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAG 485
Query: 72 ADNSCRLWDCETGKQLALL------KTNSAVRTCGFDFGGN 106
D + +WD + G ++ + + AV C F GN
Sbjct: 486 HDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGN 526
Score = 38.9 bits (89), Expect = 0.006
Identities = 17/47 (36%), Positives = 28/47 (59%)
Query: 49 MGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSA 95
+GH +V+CV D + + TGS D ++W + G+ LA L+ +SA
Sbjct: 177 LGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSA 223
Score = 32.3 bits (72), Expect = 0.59
Identities = 17/78 (21%), Positives = 33/78 (42%), Gaps = 4/78 (5%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAV----WCVDAD 61
L+GH I+ + N E L+ + D +V VW + GH+ ++ +C
Sbjct: 218 LRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTK 277
Query: 62 WDTKHVLTGSADNSCRLW 79
+++ + AD + W
Sbjct: 278 GTNRYLTSTGADGTICFW 295
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 63.5 bits (153), Expect = 2e-10
Identities = 45/210 (21%), Positives = 88/210 (41%), Gaps = 12/210 (5%)
Query: 8 GHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHV 67
GH+ +T ++++ G+LL + ++D V +W + + HT V VD D + +
Sbjct: 58 GHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFL 117
Query: 68 LTGSADNSCRLWDCETGKQL-ALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFD 126
T S D S ++W + L +L + VR F G +I+ ++ + + +D
Sbjct: 118 ATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKT-----IKIWD 172
Query: 127 LRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKE 186
+ ++N + + P G CI + + + + ++L + +
Sbjct: 173 TTNKQCVNNFSDSVGF------ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQV 226
Query: 187 HSRQINDIQLSRDMTMFVTASKDNTAKLFD 216
HS +N I +TAS D T K+ D
Sbjct: 227 HSGGVNCISFHPSGNYLITASSDGTLKILD 256
Score = 58.9 bits (141), Expect = 6e-09
Identities = 63/308 (20%), Positives = 124/308 (40%), Gaps = 33/308 (10%)
Query: 7 QGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKH 66
+GH+ +IT + + G L T + D + +W R Y+GH V V
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL 74
Query: 67 VLTGSADNSCRLWDCETGKQLALLKTNSA-VRTCGFDFGGNIIMF-STDKQMGYQCFVSF 124
+ + S D + RLW + + + K ++A VR+ F G + S DK + S
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW---SM 131
Query: 125 FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNV 184
+ R + + +++ A + P G I++ E + + + + + N
Sbjct: 132 YRQRFLYSLYRHTHWVRC---------AKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF 182
Query: 185 KEHSRQINDIQLSRDMTMFVTASKDNTAKLFD---STTLEHQKTFRTERPVNSAALSPNY 241
+ N + + T +A D T K++D + L+H + VN + P+
Sbjct: 183 SDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVH--SGGVNCISFHPSG 240
Query: 242 DHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYS 301
++++ + + + E R + ++GH GP+ +V+F G+ ++
Sbjct: 241 NYLITASSDGTLKI------LDLLEGRLIYT--------LQGHTGPVFTVSFSKGGELFA 286
Query: 302 SGGEDGYV 309
SGG D V
Sbjct: 287 SGGADTQV 294
Score = 50.4 bits (119), Expect = 2e-06
Identities = 48/266 (18%), Positives = 100/266 (37%), Gaps = 27/266 (10%)
Query: 48 YMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCET-GKQLALLKTNSAVRTCGFDFGGN 106
+ GH A+ +D + K + T S D LW+ + + + V + F GN
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 107 IIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHE 166
++ S + + ++ D + + + + + S + G+ + E
Sbjct: 74 LLA-SASRDRTVRLWIP----------DKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
Query: 167 SGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTF 226
+ +S L ++ H+ + + S D + V+ S+D T K++D+T + F
Sbjct: 123 DKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF 182
Query: 227 RTERP-VNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHF 285
N +P+ + G + + V R+ K + + H
Sbjct: 183 SDSVGFANFVDFNPSGTCIASAGSDQTVKV--WDVRVNKLLQHY------------QVHS 228
Query: 286 GPINSVAFHPDGKSYSSGGEDGYVRI 311
G +N ++FHP G + DG ++I
Sbjct: 229 GGVNCISFHPSGNYLITASSDGTLKI 254
Score = 38.1 bits (87), Expect = 0.011
Identities = 20/73 (27%), Positives = 32/73 (43%)
Query: 7 QGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKH 66
Q H + I ++ G+ L T + D + + + G + T GHTG V+ V +
Sbjct: 225 QVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGEL 284
Query: 67 VLTGSADNSCRLW 79
+G AD LW
Sbjct: 285 FASGGADTQVLLW 297
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 63.2 bits (152), Expect = 3e-10
Identities = 77/345 (22%), Positives = 147/345 (42%), Gaps = 55/345 (15%)
Query: 7 QGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLG-TYMGH----TGAVW-CVDA 60
+GH + I ++ +G L + K+ + +W G+++G T GH TG W + A
Sbjct: 153 KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHA 212
Query: 61 DWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQ----- 115
+ + ++V + S D S R+WD G+ +L ++ TC +GG+ +++S +
Sbjct: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTC-LRWGGDGLLYSASQDRTIKV 271
Query: 116 ------------MGYQCFVSFFDLR----------DPSQIDNNEPYMKIPCNDSKITSA- 152
G+ +V+ L +P++ N ++ + K +
Sbjct: 272 WRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALS 331
Query: 153 ----VWGPLGECIIAGHESGELNQYS-AKSGEVLVNVKEHSRQINDIQLSRDMTMFVTAS 207
V G E +++G + L +S A+ + L + H IN + S D + +AS
Sbjct: 332 RYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASAS 391
Query: 208 KDNTAKLFDSTTLEHQKTFRTE-RPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFE 266
D + KL+D T ++ + R V A S + +V G + V ++
Sbjct: 392 FDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKV---------WD 442
Query: 267 ARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311
+ LA + + GH + +V + PDG+ +SGG+D +RI
Sbjct: 443 VKAQKLAMD-----LPGHADEVYAVDWSPDGQRVASGGKDKCLRI 482
Score = 48.1 bits (113), Expect = 1e-05
Identities = 21/85 (24%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 2 KPIL-LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDA 60
KP+ + GH+ I Q+ ++ + ++ + + D + +W G+ L + GH AV+ +
Sbjct: 363 KPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAW 422
Query: 61 DWDTKHVLTGSADNSCRLWDCETGK 85
D++ +++GS+D++ ++WD + K
Sbjct: 423 SADSRLLVSGSSDSTLKVWDVKAQK 447
Score = 42.0 bits (97), Expect = 7e-04
Identities = 23/75 (30%), Positives = 39/75 (52%), Gaps = 2/75 (2%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYM-GHTGAVWCVDADWDT 64
L+GH ++ QI ++ + LL + + D + VW V ++L + GH V+ VD D
Sbjct: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW-DVKAQKLAMDLPGHADEVYAVDWSPDG 468
Query: 65 KHVLTGSADNSCRLW 79
+ V +G D R+W
Sbjct: 469 QRVASGGKDKCLRIW 483
Score = 37.4 bits (85), Expect = 0.018
Identities = 22/84 (26%), Positives = 36/84 (42%), Gaps = 4/84 (4%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADW--D 63
L+GH ++ + ++ G L + + D V W T GH W + W D
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRH--WVLSISWSPD 167
Query: 64 TKHVLTGSADNSCRLWDCETGKQL 87
+ + +G + LWD TGKQ+
Sbjct: 168 GRKLASGCKNGQILLWDPSTGKQV 191
Score = 33.1 bits (74), Expect = 0.35
Identities = 48/200 (24%), Positives = 84/200 (42%), Gaps = 20/200 (10%)
Query: 50 GHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTC-GFDFGGNII 108
GH+ AV V K++ +GS D + R WD L T + TC G I
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWD---------LSTETPHFTCKGHRHWVLSI 162
Query: 109 MFSTD-KQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPL---GEC--II 162
+S D +++ C L DPS + + + IT W PL EC +
Sbjct: 163 SWSPDGRKLASGCKNGQILLWDPS--TGKQVGRTLAGHSKWITGLSWEPLHANPECRYVA 220
Query: 163 AGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEH 222
+ + G + + +G + H++ + ++ D ++ +AS+D T K++ +
Sbjct: 221 SSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAHDGVL 279
Query: 223 QKTFRTE-RPVNSAALSPNY 241
+T + VN+ ALS +Y
Sbjct: 280 CRTLQGHGHWVNTMALSTDY 299
Score = 32.3 bits (72), Expect = 0.59
Identities = 23/85 (27%), Positives = 39/85 (45%), Gaps = 16/85 (18%)
Query: 232 VNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSV 291
V S A SP ++ G G + RF+ L+ E KGH + S+
Sbjct: 117 VISVAFSPTGKYLASGSGDTTV--------------RFWDLSTETPHFTCKGHRHWVLSI 162
Query: 292 AFHPDGKSYSSGGEDGYVRIHYFDP 316
++ PDG+ +SG ++G + + +DP
Sbjct: 163 SWSPDGRKLASGCKNGQILL--WDP 185
Score = 28.5 bits (62), Expect = 8.5
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 281 VKGHFGPINSVAFHPDGKSYSSGGEDGYVR 310
++GH + SVAF P GK +SG D VR
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVR 139
>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
[Homo sapiens]
Length = 2269
Score = 62.8 bits (151), Expect = 4e-10
Identities = 68/342 (19%), Positives = 136/342 (39%), Gaps = 50/342 (14%)
Query: 8 GHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHV 67
GH ++ + ++R G +FT + D +V +W + NG L T GH+ + + +++ +
Sbjct: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMI 243
Query: 68 LTGSADNSCRLWDCETGKQLALLKTN----SAVRTCGFDFGGNIIMFSTDKQMGYQCFVS 123
GS D R+W T +A+L+ + ++++ G M ST G CF
Sbjct: 244 AAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGAD-GTVCFWQ 302
Query: 124 F------FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQY--SA 175
+ F R + P +++ C+ + G + G + Y
Sbjct: 303 WDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVG-------GMFLATGSTDHVIRMYFLGF 355
Query: 176 KSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSA 235
++ E + ++ H+ +++ IQ + F++ S+D TA+++ LE + S
Sbjct: 356 EAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISG 415
Query: 236 ALSPNYDH-------VVLGGGQEAMDVTTTSTRIGK----FEARFFHLAFEEEFGRVKGH 284
LS + ++ +++ VT + + K + + H + GH
Sbjct: 416 DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLH--------NLMGH 467
Query: 285 FGPINSVAFHP-DGKSYSSGGEDGYVRI----------HYFD 315
+ + HP D + S G DG + I HYF+
Sbjct: 468 ADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN 509
>gi|16445436 bromodomain and WD repeat domain containing 1 isoform A
[Homo sapiens]
Length = 2320
Score = 62.8 bits (151), Expect = 4e-10
Identities = 68/342 (19%), Positives = 136/342 (39%), Gaps = 50/342 (14%)
Query: 8 GHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHV 67
GH ++ + ++R G +FT + D +V +W + NG L T GH+ + + +++ +
Sbjct: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMI 243
Query: 68 LTGSADNSCRLWDCETGKQLALLKTN----SAVRTCGFDFGGNIIMFSTDKQMGYQCFVS 123
GS D R+W T +A+L+ + ++++ G M ST G CF
Sbjct: 244 AAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGAD-GTVCFWQ 302
Query: 124 F------FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQY--SA 175
+ F R + P +++ C+ + G + G + Y
Sbjct: 303 WDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVG-------GMFLATGSTDHVIRMYFLGF 355
Query: 176 KSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSA 235
++ E + ++ H+ +++ IQ + F++ S+D TA+++ LE + S
Sbjct: 356 EAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISG 415
Query: 236 ALSPNYDH-------VVLGGGQEAMDVTTTSTRIGK----FEARFFHLAFEEEFGRVKGH 284
LS + ++ +++ VT + + K + + H + GH
Sbjct: 416 DLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLH--------NLMGH 467
Query: 285 FGPINSVAFHP-DGKSYSSGGEDGYVRI----------HYFD 315
+ + HP D + S G DG + I HYF+
Sbjct: 468 ADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN 509
>gi|34996489 pleckstrin homology domain interacting protein [Homo
sapiens]
Length = 1821
Score = 62.0 bits (149), Expect = 7e-10
Identities = 52/216 (24%), Positives = 97/216 (44%), Gaps = 12/216 (5%)
Query: 8 GHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHV 67
GH S+ + ++R G +FT + D +V +W + +G L T GH + + +++ +
Sbjct: 181 GHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMI 240
Query: 68 LTGSADNSCRLWDCETGKQLALLKTNSA-VRTCGFD--FGGNIIMFSTDKQMGYQCFVSF 124
GS D R+W T LA+L+ +SA + + F G+ S+ G CF
Sbjct: 241 AAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFW-- 298
Query: 125 FDLRDPSQIDNN---EPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSG--E 179
L D + N + + P ++ + + G + G + Y SG E
Sbjct: 299 --LWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPE 356
Query: 180 VLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLF 215
+ ++ H+ +++ IQ S FV+ S+D TA+++
Sbjct: 357 KISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIW 392
Score = 38.1 bits (87), Expect = 0.011
Identities = 22/88 (25%), Positives = 43/88 (48%), Gaps = 6/88 (6%)
Query: 6 LQGHERSITQIK-----YNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDA 60
LQG E IT++K ++R + + T + + VW S G+ + MGH V+ ++
Sbjct: 415 LQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEP 474
Query: 61 -DWDTKHVLTGSADNSCRLWDCETGKQL 87
+D + + + D + +WD G ++
Sbjct: 475 HPFDPRVLFSAGHDGNVIVWDLARGVKI 502
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 61.6 bits (148), Expect = 9e-10
Identities = 58/273 (21%), Positives = 112/273 (41%), Gaps = 38/273 (13%)
Query: 8 GHE----RSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWD 63
GH+ + +T + +N +G LL + D +W + NG T H G ++ + +
Sbjct: 229 GHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKK 287
Query: 64 TKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVS 123
+VL+ D + +WD TG+ +SA D+ N+ S M C
Sbjct: 288 GNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSA-PALDVDWQNNMTFASCSTDM---CI-- 341
Query: 124 FFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVN 183
++ + P + +++ + W P G + + + L +S K + +
Sbjct: 342 -----HVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHD 396
Query: 184 VKEHSRQINDIQLS---------RDMTMFVTASKDNTAKLFD-------STTLEHQKTFR 227
++ HS++I I+ S M +AS D+T +L+D T ++HQ+
Sbjct: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQE--- 453
Query: 228 TERPVNSAALSPNYDHVVLGGGQEAMDVTTTST 260
PV S A SP+ ++ G + + + T +
Sbjct: 454 ---PVYSVAFSPDGKYLASGSFDKYVHIWNTQS 483
Score = 37.4 bits (85), Expect = 0.018
Identities = 24/88 (27%), Positives = 39/88 (44%), Gaps = 9/88 (10%)
Query: 6 LQGHERSITQIKYNREGD---------LLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVW 56
LQ H + I IK++ G +L + + D V +W G T M H V+
Sbjct: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVY 456
Query: 57 CVDADWDTKHVLTGSADNSCRLWDCETG 84
V D K++ +GS D +W+ ++G
Sbjct: 457 SVAFSPDGKYLASGSFDKYVHIWNTQSG 484
Score = 33.1 bits (74), Expect = 0.35
Identities = 21/89 (23%), Positives = 35/89 (39%), Gaps = 13/89 (14%)
Query: 7 QGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKH 66
QGH + IK++ G LL + + D + +W + H+ ++ + W
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTI--KWSPTG 413
Query: 67 VLT-----------GSADNSCRLWDCETG 84
T S D++ RLWD E G
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQG 442
Score = 31.6 bits (70), Expect = 1.0
Identities = 37/171 (21%), Positives = 73/171 (42%), Gaps = 18/171 (10%)
Query: 142 IPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMT 201
+P N +TS W G + G G ++ ++G + + +H I ++ ++
Sbjct: 232 VPSNKD-VTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 202 MFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSA-ALSPNYDHVVLGGGQEAMDVTTTST 260
++A D T ++D+ T E ++ F P +SA AL ++ Q M + ST
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQF----PFHSAPALDVDW--------QNNMTFASCST 337
Query: 261 RIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311
+ R L + +GH +N++ + P G +S +D ++I
Sbjct: 338 DMCIHVCR---LGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 385
Score = 28.5 bits (62), Expect = 8.5
Identities = 14/67 (20%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65
L H+ + + ++ +G L + + D V++W + +G + +Y G TG ++ + W+ +
Sbjct: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIF--EVCWNAR 504
Query: 66 HVLTGSA 72
G++
Sbjct: 505 GDKVGAS 511
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 61.6 bits (148), Expect = 9e-10
Identities = 58/273 (21%), Positives = 112/273 (41%), Gaps = 38/273 (13%)
Query: 8 GHE----RSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWD 63
GH+ + +T + +N +G LL + D +W + NG T H G ++ + +
Sbjct: 229 GHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKK 287
Query: 64 TKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVS 123
+VL+ D + +WD TG+ +SA D+ N+ S M C
Sbjct: 288 GNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSA-PALDVDWQNNMTFASCSTDM---CI-- 341
Query: 124 FFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVN 183
++ + P + +++ + W P G + + + L +S K + +
Sbjct: 342 -----HVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHD 396
Query: 184 VKEHSRQINDIQLS---------RDMTMFVTASKDNTAKLFD-------STTLEHQKTFR 227
++ HS++I I+ S M +AS D+T +L+D T ++HQ+
Sbjct: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQE--- 453
Query: 228 TERPVNSAALSPNYDHVVLGGGQEAMDVTTTST 260
PV S A SP+ ++ G + + + T +
Sbjct: 454 ---PVYSVAFSPDGKYLASGSFDKYVHIWNTQS 483
Score = 37.4 bits (85), Expect = 0.018
Identities = 24/88 (27%), Positives = 39/88 (44%), Gaps = 9/88 (10%)
Query: 6 LQGHERSITQIKYNREGD---------LLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVW 56
LQ H + I IK++ G +L + + D V +W G T M H V+
Sbjct: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVY 456
Query: 57 CVDADWDTKHVLTGSADNSCRLWDCETG 84
V D K++ +GS D +W+ ++G
Sbjct: 457 SVAFSPDGKYLASGSFDKYVHIWNTQSG 484
Score = 33.1 bits (74), Expect = 0.35
Identities = 21/89 (23%), Positives = 35/89 (39%), Gaps = 13/89 (14%)
Query: 7 QGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKH 66
QGH + IK++ G LL + + D + +W + H+ ++ + W
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTI--KWSPTG 413
Query: 67 VLT-----------GSADNSCRLWDCETG 84
T S D++ RLWD E G
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQG 442
Score = 31.6 bits (70), Expect = 1.0
Identities = 37/171 (21%), Positives = 73/171 (42%), Gaps = 18/171 (10%)
Query: 142 IPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMT 201
+P N +TS W G + G G ++ ++G + + +H I ++ ++
Sbjct: 232 VPSNKD-VTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 202 MFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSA-ALSPNYDHVVLGGGQEAMDVTTTST 260
++A D T ++D+ T E ++ F P +SA AL ++ Q M + ST
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQF----PFHSAPALDVDW--------QNNMTFASCST 337
Query: 261 RIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311
+ R L + +GH +N++ + P G +S +D ++I
Sbjct: 338 DMCIHVCR---LGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 385
Score = 28.5 bits (62), Expect = 8.5
Identities = 14/67 (20%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65
L H+ + + ++ +G L + + D V++W + +G + +Y G TG ++ + W+ +
Sbjct: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIF--EVCWNAR 504
Query: 66 HVLTGSA 72
G++
Sbjct: 505 GDKVGAS 511
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 61.6 bits (148), Expect = 9e-10
Identities = 58/273 (21%), Positives = 112/273 (41%), Gaps = 38/273 (13%)
Query: 8 GHE----RSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWD 63
GH+ + +T + +N +G LL + D +W + NG T H G ++ + +
Sbjct: 229 GHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKK 287
Query: 64 TKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVS 123
+VL+ D + +WD TG+ +SA D+ N+ S M C
Sbjct: 288 GNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSA-PALDVDWQNNMTFASCSTDM---CI-- 341
Query: 124 FFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVN 183
++ + P + +++ + W P G + + + L +S K + +
Sbjct: 342 -----HVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHD 396
Query: 184 VKEHSRQINDIQLS---------RDMTMFVTASKDNTAKLFD-------STTLEHQKTFR 227
++ HS++I I+ S M +AS D+T +L+D T ++HQ+
Sbjct: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQE--- 453
Query: 228 TERPVNSAALSPNYDHVVLGGGQEAMDVTTTST 260
PV S A SP+ ++ G + + + T +
Sbjct: 454 ---PVYSVAFSPDGKYLASGSFDKYVHIWNTQS 483
Score = 37.4 bits (85), Expect = 0.018
Identities = 24/88 (27%), Positives = 39/88 (44%), Gaps = 9/88 (10%)
Query: 6 LQGHERSITQIKYNREGD---------LLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVW 56
LQ H + I IK++ G +L + + D V +W G T M H V+
Sbjct: 397 LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVY 456
Query: 57 CVDADWDTKHVLTGSADNSCRLWDCETG 84
V D K++ +GS D +W+ ++G
Sbjct: 457 SVAFSPDGKYLASGSFDKYVHIWNTQSG 484
Score = 33.1 bits (74), Expect = 0.35
Identities = 21/89 (23%), Positives = 35/89 (39%), Gaps = 13/89 (14%)
Query: 7 QGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKH 66
QGH + IK++ G LL + + D + +W + H+ ++ + W
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTI--KWSPTG 413
Query: 67 VLT-----------GSADNSCRLWDCETG 84
T S D++ RLWD E G
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQG 442
Score = 31.6 bits (70), Expect = 1.0
Identities = 37/171 (21%), Positives = 73/171 (42%), Gaps = 18/171 (10%)
Query: 142 IPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMT 201
+P N +TS W G + G G ++ ++G + + +H I ++ ++
Sbjct: 232 VPSNKD-VTSLDWNSDGTLLAMGSYDGFARIWT-ENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 202 MFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSA-ALSPNYDHVVLGGGQEAMDVTTTST 260
++A D T ++D+ T E ++ F P +SA AL ++ Q M + ST
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQF----PFHSAPALDVDW--------QNNMTFASCST 337
Query: 261 RIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311
+ R L + +GH +N++ + P G +S +D ++I
Sbjct: 338 DMCIHVCR---LGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 385
Score = 28.5 bits (62), Expect = 8.5
Identities = 14/67 (20%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65
L H+ + + ++ +G L + + D V++W + +G + +Y G TG ++ + W+ +
Sbjct: 448 LMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIF--EVCWNAR 504
Query: 66 HVLTGSA 72
G++
Sbjct: 505 GDKVGAS 511
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 61.6 bits (148), Expect = 9e-10
Identities = 70/314 (22%), Positives = 120/314 (38%), Gaps = 33/314 (10%)
Query: 7 QGHERSITQIKYN----REGDLLFTVAKDPIVNVWYSVNGERLG---TYMGHTGAVWCVD 59
Q H+ +I + + + + T + D +V VW ERL + GH V VD
Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVW-KWRDERLDLQWSLEGHQLGVVSVD 71
Query: 60 ADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQ 119
+ S D RLWD E GKQ+ + V F + +T +G
Sbjct: 72 ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGP-VDAWTLAFSPDSQYLATGTHVGK- 129
Query: 120 CFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGE 179
V+ F +++ + + I S + P G+ + +G G +N + +G+
Sbjct: 130 --VNIFG------VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGK 181
Query: 180 VLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERP-VNSAALS 238
+L ++ H+ I + S D + VTAS D K++D T V + A
Sbjct: 182 LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFC 241
Query: 239 PNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGK 298
P+ H V +++ V TR H F+ H + V ++ +G
Sbjct: 242 PDDTHFVSSSSDKSVKVWDVGTR------TCVHTFFD--------HQDQVWGVKYNGNGS 287
Query: 299 SYSSGGEDGYVRIH 312
S G+D + I+
Sbjct: 288 KIVSVGDDQEIHIY 301
Score = 45.8 bits (107), Expect = 5e-05
Identities = 37/222 (16%), Positives = 88/222 (39%), Gaps = 12/222 (5%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65
L+GH+ + + + + + + D + +W NG+++ + W + D++
Sbjct: 60 LEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQ 119
Query: 66 HVLTGSADNSCRLWDCETGKQLALLKTNSA-VRTCGFDFGGNIIMFSTDKQMGYQCFVSF 124
++ TG+ ++ E+GK+ L T + + + G + ++
Sbjct: 120 YLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASG-----AIDGIINI 174
Query: 125 FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNV 184
FD+ + E + I S + P + ++ + G + Y + + +
Sbjct: 175 FDIATGKLLHTLEGHA------MPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTL 228
Query: 185 KEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTF 226
H+ + ++ D T FV++S D + K++D T TF
Sbjct: 229 SGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
Score = 36.6 bits (83), Expect = 0.031
Identities = 33/138 (23%), Positives = 60/138 (43%), Gaps = 12/138 (8%)
Query: 2 KPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDAD 61
K L + I I Y+ +G L + A D I+N++ G+ L T GH + +
Sbjct: 140 KEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFS 199
Query: 62 WDTKHVLTGSADNSCRLWDCETGKQLALLKTNSA----VRTCGFDFGGNIIMFSTDKQMG 117
D++ ++T S D +++D + L +++ V C D + + S+DK +
Sbjct: 200 PDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDD--THFVSSSSDKSVK 257
Query: 118 Y------QCFVSFFDLRD 129
C +FFD +D
Sbjct: 258 VWDVGTRTCVHTFFDHQD 275
Score = 29.3 bits (64), Expect = 5.0
Identities = 15/76 (19%), Positives = 30/76 (39%)
Query: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65
L GH + + + + + + D V VW + T+ H VW V + +
Sbjct: 228 LSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGS 287
Query: 66 HVLTGSADNSCRLWDC 81
+++ D ++DC
Sbjct: 288 KIVSVGDDQEIHIYDC 303
>gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]
Length = 919
Score = 61.6 bits (148), Expect = 9e-10
Identities = 38/166 (22%), Positives = 75/166 (45%), Gaps = 13/166 (7%)
Query: 147 SKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTA 206
+ + + + P G+ I+ G + G++ ++ SG V EHS + + + + VT+
Sbjct: 374 NSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTS 433
Query: 207 SKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYD-HVVLGGGQEAMDVTTTSTRIGKF 265
S D T + FD + +TF + RP + ++ + +V G Q++ ++ S + G+
Sbjct: 434 SMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRL 493
Query: 266 EARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311
+ GH GPI+ + F+P +S D VR+
Sbjct: 494 ------------LDVLSGHEGPISGLCFNPMKSVLASASWDKTVRL 527
Score = 41.2 bits (95), Expect = 0.001
Identities = 65/334 (19%), Positives = 119/334 (35%), Gaps = 75/334 (22%)
Query: 7 QGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKH 66
QGH S+ + Y+ +G + T D V VW +++G T+ H+ V V
Sbjct: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
Query: 67 VLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFD 126
V+T S D + R +D + N F++ + + C
Sbjct: 430 VVTSSMDGTVRAFDLHRYR--------------------NFRTFTSPRPTQFSCVA---- 465
Query: 127 LRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAG-HESGELNQYSAKSGEVLVNVK 185
+D + GE + AG +S E+ +S ++G +L +
Sbjct: 466 ------VDAS---------------------GEIVSAGAQDSFEIFVWSMQTGRLLDVLS 498
Query: 186 EHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVV 245
H I+ + + ++ +AS D T +L+D F + R + AL+ + V
Sbjct: 499 GHEGPISGLCFNPMKSVLASASWDKTVRLWD--------MFDSWRTKETLALTSDALAVT 550
Query: 246 LGGGQEAMDVTTTSTRI-----------GKFEARFFHLAFEEEFGRVKGHFG----PINS 290
+ V T +++I G E R +E ++ +
Sbjct: 551 FRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTA 610
Query: 291 VAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFE 324
+ + DG S +GG +V I++ Q FE
Sbjct: 611 LCYSADGHSILAGGMSKFVCIYHVREQILMKRFE 644
Score = 28.9 bits (63), Expect = 6.5
Identities = 19/94 (20%), Positives = 37/94 (39%)
Query: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64
+L GHE I+ + +N +L + + D V +W + R + T V D
Sbjct: 496 VLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDG 555
Query: 65 KHVLTGSADNSCRLWDCETGKQLALLKTNSAVRT 98
+ + ++ WD E Q ++ ++T
Sbjct: 556 AELAVATLNSQITFWDPENAVQTGSIEGRHDLKT 589
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 61.2 bits (147), Expect = 1e-09
Identities = 67/261 (25%), Positives = 113/261 (43%), Gaps = 30/261 (11%)
Query: 30 KDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQL-A 88
+D + +W + E L GHTG+V C+ +D + ++TGS+D++ R+WD TG+ L
Sbjct: 258 RDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSSDSTVRVWDVNTGEVLNT 315
Query: 89 LLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSK 148
L+ N AV F G ++ S D+ + S D+ + + + + D K
Sbjct: 316 LIHHNEAVLHLRFS-NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK 374
Query: 149 ITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASK 208
I++ + +S + E + + H R I +Q RD + V+ S
Sbjct: 375 Y-----------IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY-RD-RLVVSGSS 421
Query: 209 DNTAKLFD------STTLE-HQKTFRTERPVNSAALSPNYD-HVVLGGGQEAMD-----V 255
DNT +L+D LE H++ R R N +S YD + + Q A+D
Sbjct: 422 DNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPAS 481
Query: 256 TTTSTRIGKFEARFFHLAFEE 276
T + + R F L F+E
Sbjct: 482 TLCLRTLVEHSGRVFRLQFDE 502
Score = 45.8 bits (107), Expect = 5e-05
Identities = 25/95 (26%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64
+L GH ++ + ++ + + + + D + VW + E + T GH + C+ +
Sbjct: 358 VLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQ--YRD 413
Query: 65 KHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTC 99
+ V++GS+DN+ RLWD E G L +L+ + + C
Sbjct: 414 RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRC 448
Score = 37.7 bits (86), Expect = 0.014
Identities = 28/102 (27%), Positives = 46/102 (45%), Gaps = 8/102 (7%)
Query: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64
+L GH S+ ++Y+ ++ T + D V VW GE L T + H AV + +
Sbjct: 275 VLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAV--LHLRFSN 330
Query: 65 KHVLTGSADNSCRLWDCETGKQLALLKT----NSAVRTCGFD 102
++T S D S +WD + + L + +AV FD
Sbjct: 331 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFD 372
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 61.2 bits (147), Expect = 1e-09
Identities = 67/261 (25%), Positives = 113/261 (43%), Gaps = 30/261 (11%)
Query: 30 KDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQL-A 88
+D + +W + E L GHTG+V C+ +D + ++TGS+D++ R+WD TG+ L
Sbjct: 224 RDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSSDSTVRVWDVNTGEVLNT 281
Query: 89 LLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSK 148
L+ N AV F G ++ S D+ + S D+ + + + + D K
Sbjct: 282 LIHHNEAVLHLRFS-NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK 340
Query: 149 ITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASK 208
I++ + +S + E + + H R I +Q RD + V+ S
Sbjct: 341 Y-----------IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY-RD-RLVVSGSS 387
Query: 209 DNTAKLFD------STTLE-HQKTFRTERPVNSAALSPNYD-HVVLGGGQEAMD-----V 255
DNT +L+D LE H++ R R N +S YD + + Q A+D
Sbjct: 388 DNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPAS 447
Query: 256 TTTSTRIGKFEARFFHLAFEE 276
T + + R F L F+E
Sbjct: 448 TLCLRTLVEHSGRVFRLQFDE 468
Score = 45.8 bits (107), Expect = 5e-05
Identities = 25/95 (26%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64
+L GH ++ + ++ + + + + D + VW + E + T GH + C+ +
Sbjct: 324 VLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQ--YRD 379
Query: 65 KHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTC 99
+ V++GS+DN+ RLWD E G L +L+ + + C
Sbjct: 380 RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRC 414
Score = 37.7 bits (86), Expect = 0.014
Identities = 28/102 (27%), Positives = 46/102 (45%), Gaps = 8/102 (7%)
Query: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64
+L GH S+ ++Y+ ++ T + D V VW GE L T + H AV + +
Sbjct: 241 VLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAV--LHLRFSN 296
Query: 65 KHVLTGSADNSCRLWDCETGKQLALLKT----NSAVRTCGFD 102
++T S D S +WD + + L + +AV FD
Sbjct: 297 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFD 338
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 61.2 bits (147), Expect = 1e-09
Identities = 67/261 (25%), Positives = 113/261 (43%), Gaps = 30/261 (11%)
Query: 30 KDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQL-A 88
+D + +W + E L GHTG+V C+ +D + ++TGS+D++ R+WD TG+ L
Sbjct: 245 RDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSSDSTVRVWDVNTGEVLNT 302
Query: 89 LLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSK 148
L+ N AV F G ++ S D+ + S D+ + + + + D K
Sbjct: 303 LIHHNEAVLHLRFS-NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK 361
Query: 149 ITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASK 208
I++ + +S + E + + H R I +Q RD + V+ S
Sbjct: 362 Y-----------IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY-RD-RLVVSGSS 408
Query: 209 DNTAKLFD------STTLE-HQKTFRTERPVNSAALSPNYD-HVVLGGGQEAMD-----V 255
DNT +L+D LE H++ R R N +S YD + + Q A+D
Sbjct: 409 DNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPAS 468
Query: 256 TTTSTRIGKFEARFFHLAFEE 276
T + + R F L F+E
Sbjct: 469 TLCLRTLVEHSGRVFRLQFDE 489
Score = 45.8 bits (107), Expect = 5e-05
Identities = 25/95 (26%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64
+L GH ++ + ++ + + + + D + VW + E + T GH + C+ +
Sbjct: 345 VLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQ--YRD 400
Query: 65 KHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTC 99
+ V++GS+DN+ RLWD E G L +L+ + + C
Sbjct: 401 RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRC 435
Score = 37.7 bits (86), Expect = 0.014
Identities = 28/102 (27%), Positives = 46/102 (45%), Gaps = 8/102 (7%)
Query: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64
+L GH S+ ++Y+ ++ T + D V VW GE L T + H AV + +
Sbjct: 262 VLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAV--LHLRFSN 317
Query: 65 KHVLTGSADNSCRLWDCETGKQLALLKT----NSAVRTCGFD 102
++T S D S +WD + + L + +AV FD
Sbjct: 318 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFD 359
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 60.8 bits (146), Expect = 2e-09
Identities = 56/266 (21%), Positives = 107/266 (40%), Gaps = 34/266 (12%)
Query: 11 RSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTG 70
+ +T + +N EG LL T + D +W + +G T H G ++ + + +L+
Sbjct: 226 KDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSA 284
Query: 71 SADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDP 130
D + +WD TG+ +SA D+ N S M C
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSA-PALDVDWQSNNTFASCSTDM---CI-------HV 333
Query: 131 SQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQ 190
++ + P + +++ + W P G + + + L +S K + +++ H+++
Sbjct: 334 CKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKE 393
Query: 191 INDIQLS---------RDMTMFVTASKDNTAKLFD-------STTLEHQKTFRTERPVNS 234
I I+ S M +AS D+T +L+D T +HQ+ PV S
Sbjct: 394 IYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQE------PVYS 447
Query: 235 AALSPNYDHVVLGGGQEAMDVTTTST 260
A SP+ ++ G + + + T T
Sbjct: 448 VAFSPDGRYLASGSFDKCVHIWNTQT 473
Score = 36.2 bits (82), Expect = 0.041
Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 9/88 (10%)
Query: 6 LQGHERSITQIKYNREGD---------LLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVW 56
LQ H + I IK++ G +L + + D V +W G + T H V+
Sbjct: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVY 446
Query: 57 CVDADWDTKHVLTGSADNSCRLWDCETG 84
V D +++ +GS D +W+ +TG
Sbjct: 447 SVAFSPDGRYLASGSFDKCVHIWNTQTG 474
Score = 33.5 bits (75), Expect = 0.26
Identities = 64/338 (18%), Positives = 116/338 (34%), Gaps = 58/338 (17%)
Query: 2 KPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGT---YMGHTGAVWCV 58
K ++L+GHE + +N DLL + + D +W G+ + H
Sbjct: 161 KAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQ 220
Query: 59 DA---------DWDTKHVL--TGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNI 107
D DW+++ L TGS D R+W + L + + ++ GN
Sbjct: 221 DVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNF 280
Query: 108 IMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVW---GPLGECIIAG 164
I+ + G +D E + P + + W C
Sbjct: 281 ILSA-----GVDKTTIIWDAH------TGEAKQQFPFHSAPALDVDWQSNNTFASC---- 325
Query: 165 HESGELNQYSAKSGE--VLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTT--- 219
S ++ + K G+ + + H+ ++N I+ + + S D T K++
Sbjct: 326 --STDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNC 383
Query: 220 ----LEHQKTFRTER--PVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLA 273
H K T + P +PN + ++ ++ R + +
Sbjct: 384 VHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDST-------------VRLWDVD 430
Query: 274 FEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311
+ H P+ SVAF PDG+ +SG D V I
Sbjct: 431 RGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHI 468
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,157,884
Number of Sequences: 37866
Number of extensions: 519378
Number of successful extensions: 2721
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 194
Number of HSP's successfully gapped in prelim test: 73
Number of HSP's that attempted gapping in prelim test: 1125
Number of HSP's gapped (non-prelim): 1212
length of query: 325
length of database: 18,247,518
effective HSP length: 102
effective length of query: 223
effective length of database: 14,385,186
effective search space: 3207896478
effective search space used: 3207896478
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.