Search of human proteins with 4503143

Search of human proteins with 4503143

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503143 cathepsin D preproprotein [Homo sapiens]
         (412 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503143 cathepsin D preproprotein [Homo sapiens]                   832   0.0  
gi|4758754 napsin A preproprotein [Homo sapiens]                      386   e-107
gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens]         363   e-100
gi|119372302 pepsinogen 4, group I [Homo sapiens]                     332   3e-91
gi|119372298 pepsinogen 3, group I [Homo sapiens]                     332   4e-91
gi|23943854 pepsinogen 5, group I [Homo sapiens]                      331   6e-91
gi|4506475 renin preproprotein [Homo sapiens]                         328   4e-90
gi|4505757 progastricsin (pepsinogen C) [Homo sapiens]                289   4e-78
gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens]        215   5e-56
gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprot...   103   2e-22
gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprot...   103   3e-22
gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprote...   101   1e-21
gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprot...    96   5e-20
gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprot...    87   2e-17
gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprot...    74   2e-13
gi|169218035 PREDICTED: similar to pepsinogen 3, group I [Homo s...    69   8e-12
gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprot...    54   3e-07
gi|63003930 transmembrane protein 30B [Homo sapiens]                   32   1.1  
gi|93141016 motile sperm domain containing 3 isoform b [Homo sap...    29   8.9  

>gi|4503143 cathepsin D preproprotein [Homo sapiens]
          Length = 412

 Score =  832 bits (2150), Expect = 0.0
 Identities = 412/412 (100%), Positives = 412/412 (100%)

Query: 1   MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP 60
           MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
Sbjct: 1   MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP 60

Query: 61  AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH 120
           AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
Sbjct: 61  AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH 120

Query: 121 HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG 180
           HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
Sbjct: 121 HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG 180

Query: 181 EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ 240
           EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
Sbjct: 181 EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ 240

Query: 241 PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL 300
           PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
Sbjct: 241 PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL 300

Query: 301 MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ 360
           MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
Sbjct: 301 MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ 360

Query: 361 AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL 412
           AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
Sbjct: 361 AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL 412


>gi|4758754 napsin A preproprotein [Homo sapiens]
          Length = 420

 Score =  386 bits (991), Expect = e-107
 Identities = 192/413 (46%), Positives = 265/413 (64%), Gaps = 22/413 (5%)

Query: 1   MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP 60
           +QP  LL L L  +    + L+RIPLH+    RR ++ + G  E      P        P
Sbjct: 7   LQPLLLL-LPLLNVEPSGATLIRIPLHRVQPGRRILNLLRGWRE------PAELPKLGAP 59

Query: 61  AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH 120
           +  + PI   L NY D QY+GEIG+GTPPQ FTV FDTGSSNLWVPS  C    + CW+H
Sbjct: 60  SPGDKPIFVPLSNYRDVQYFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLH 119

Query: 121 HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG 180
           H+++   SS++  NGT F I YG+G + G LS+D +++           GG+K    +FG
Sbjct: 120 HRFDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTI-----------GGIKGASVIFG 168

Query: 181 EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ 240
           EA  +P + F  A FDGILG+ +P +SV  V P  D L++Q L+D+ +FSFYL+RDP+  
Sbjct: 169 EALWEPSLVFAFAHFDGILGLGFPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPEEP 228

Query: 241 PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL 300
            GGEL+LGG+D  +Y   L+++ VT  AYWQ+H+++V+V  GLTLC +GC AI+DTGTSL
Sbjct: 229 DGGELVLGGSDPAHYIPPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDTGTSL 288

Query: 301 MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ 360
           + GP +E+R L  AIG +PL+ GEY+I C ++  LPA++  LGG  + L+  DY ++ ++
Sbjct: 289 ITGPTEEIRALHAAIGGIPLLAGEYIILCSEIPKLPAVSFLLGGVWFNLTAHDYVIQTTR 348

Query: 361 AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDR----DNNRVGFAEA 409
            G  LCLSGF  +D+PPP+GP WILGDVF+G Y  VFDR     + RVG A A
Sbjct: 349 NGVRLCLSGFQALDVPPPAGPFWILGDVFLGTYVAVFDRGDMKSSARVGLARA 401


>gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens]
          Length = 396

 Score =  363 bits (932), Expect = e-100
 Identities = 186/409 (45%), Positives = 254/409 (62%), Gaps = 15/409 (3%)

Query: 1   MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP 60
           M+   LL L L  L     +L R+PL +  S+++ +      + +      +        
Sbjct: 1   MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKL-RARSQLSEFWKSHNLDMIQFTES 59

Query: 61  AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH 120
              +    E L NY+D +Y+G I IG+PPQ FTV+FDTGSSNLWVPS++C     AC  H
Sbjct: 60  CSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCT--SPACKTH 117

Query: 121 HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG 180
            ++   +SSTY + G SF I YG+GSLSG +  D VSV            G+ V  Q FG
Sbjct: 118 SRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVE-----------GLTVVGQQFG 166

Query: 181 EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ 240
           E+  +PG TF+ A+FDGILG+ YP ++V  V PVFDN+M Q LVD  +FS Y+S +P+  
Sbjct: 167 ESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGG 226

Query: 241 PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL 300
            G EL+ GG D  ++ GSL+++ VT++AYWQ+ LD ++V   +  C EGC+AIVDTGTSL
Sbjct: 227 AGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSL 286

Query: 301 MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ 360
           + GP D++++LQ AIGA P + GEY + C  ++ +P +T  + G  Y LSP  YTL    
Sbjct: 287 ITGPSDKIKQLQNAIGAAP-VDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFV 345

Query: 361 AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEA 409
            G   C SGF G+DI PP+GPLWILGDVFI ++Y+VFDR NNRVG A A
Sbjct: 346 DGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPA 394


>gi|119372302 pepsinogen 4, group I [Homo sapiens]
          Length = 388

 Score =  332 bits (852), Expect = 3e-91
 Identities = 183/408 (44%), Positives = 246/408 (60%), Gaps = 30/408 (7%)

Query: 9   LALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAK---GPVSKYS---QAVPAV 62
           L L L+A     + ++PL +  S+RRT+SE  G ++D + K    P  KY    +A   V
Sbjct: 5   LLLGLVALSECIMYKVPLIRKKSLRRTLSE-RGLLKDFLKKHNLNPARKYFPQWEAPTLV 63

Query: 63  TEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHK 122
            E P    L+NY+D +Y+G IGIGTP Q FTVVFDTGSSNLWVPS++C  L  AC  H++
Sbjct: 64  DEQP----LENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSL--ACTNHNR 117

Query: 123 YNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEA 182
           +N + SSTY     +  I YG+GS++G L  DTV V           GG+    Q+FG +
Sbjct: 118 FNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQV-----------GGISDTNQIFGLS 166

Query: 183 TKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPG 242
             +PG     A FDGILG+AYP IS +   PVFDN+  Q LV Q++FS YLS D   Q G
Sbjct: 167 ETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADD--QSG 224

Query: 243 GELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMV 302
             ++ GG DS YY GSL+++ VT + YWQ+ +D + +      C EGC+AIVDTGTSL+ 
Sbjct: 225 SVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLT 284

Query: 303 GPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAG 362
           GP   +  +Q  IGA     G+ ++ C  +S+LP I   + G  Y + P  Y L+     
Sbjct: 285 GPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQ----S 340

Query: 363 KTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAA 410
           +  C+SGF GM++P  SG LWILGDVFI +Y+TVFDR NN+VG A  A
Sbjct: 341 EGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA 388


>gi|119372298 pepsinogen 3, group I [Homo sapiens]
          Length = 388

 Score =  332 bits (851), Expect = 4e-91
 Identities = 183/408 (44%), Positives = 246/408 (60%), Gaps = 30/408 (7%)

Query: 9   LALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAK---GPVSKYS---QAVPAV 62
           L L L+A     + ++PL +  S+RRT+SE  G ++D + K    P  KY    +A   V
Sbjct: 5   LLLGLVALSECIMYKVPLIRKKSLRRTLSE-RGLLKDFLKKHNLNPARKYFPQWKAPTLV 63

Query: 63  TEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHK 122
            E P    L+NY+D +Y+G IGIGTP Q FTVVFDTGSSNLWVPS++C  L  AC  H++
Sbjct: 64  DEQP----LENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSL--ACTNHNR 117

Query: 123 YNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEA 182
           +N + SSTY     +  I YG+GS++G L  DTV V           GG+    Q+FG +
Sbjct: 118 FNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQV-----------GGISDTNQIFGLS 166

Query: 183 TKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPG 242
             +PG     A FDGILG+AYP IS +   PVFDN+  Q LV Q++FS YLS D   Q G
Sbjct: 167 ETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADD--QSG 224

Query: 243 GELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMV 302
             ++ GG DS YY GSL+++ VT + YWQ+ +D + +      C EGC+AIVDTGTSL+ 
Sbjct: 225 SVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLT 284

Query: 303 GPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAG 362
           GP   +  +Q  IGA     G+ ++ C  +S+LP I   + G  Y + P  Y L+     
Sbjct: 285 GPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQ----S 340

Query: 363 KTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAA 410
           +  C+SGF GM++P  SG LWILGDVFI +Y+TVFDR NN+VG A  A
Sbjct: 341 EGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA 388


>gi|23943854 pepsinogen 5, group I [Homo sapiens]
          Length = 388

 Score =  331 bits (849), Expect = 6e-91
 Identities = 182/408 (44%), Positives = 246/408 (60%), Gaps = 30/408 (7%)

Query: 9   LALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAK---GPVSKYS---QAVPAV 62
           L L L+A     + ++PL +  S+RRT+SE  G ++D + K    P  KY    +A   V
Sbjct: 5   LLLGLVALSECIMYKVPLIRKKSLRRTLSE-RGLLKDFLKKHNLNPARKYFPQWEAPTLV 63

Query: 63  TEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHK 122
            E P    L+NY+D +Y+G IGIGTP Q FTVVFDTGSSNLWVPS++C  L  AC  H++
Sbjct: 64  DEQP----LENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSL--ACTNHNR 117

Query: 123 YNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEA 182
           +N + SSTY     +  I YG+GS++G L  DTV V           GG+    Q+FG +
Sbjct: 118 FNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQV-----------GGISDTNQIFGLS 166

Query: 183 TKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPG 242
             +PG     A FDGILG+AYP IS +   PVFDN+  Q LV Q++FS YLS D  +  G
Sbjct: 167 ETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKS--G 224

Query: 243 GELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMV 302
             ++ GG DS YY GSL+++ VT + YWQ+ +D + +      C EGC+AIVDTGTSL+ 
Sbjct: 225 SVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLT 284

Query: 303 GPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAG 362
           GP   +  +Q  IGA     G+ ++ C  +S+LP I   + G  Y + P  Y L+     
Sbjct: 285 GPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQ----S 340

Query: 363 KTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAA 410
           +  C+SGF GM++P  SG LWILGDVFI +Y+TVFDR NN+VG A  A
Sbjct: 341 EGSCISGFQGMNVPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA 388


>gi|4506475 renin preproprotein [Homo sapiens]
          Length = 406

 Score =  328 bits (842), Expect = 4e-90
 Identities = 169/400 (42%), Positives = 246/400 (61%), Gaps = 22/400 (5%)

Query: 14  LAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPE--VL 71
           L    +   RI L +  SIR ++ E G    D+   GP  ++SQ +  +T G      +L
Sbjct: 24  LPTDTTTFKRIFLKRMPSIRESLKERG---VDMARLGP--EWSQPMKRLTLGNTTSSVIL 78

Query: 72  KNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTY 131
            NYMD QYYGEIGIGTPPQ F VVFDTGSSN+WVPS  C  L  AC  H  +++  SS+Y
Sbjct: 79  TNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSY 138

Query: 132 VKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFI 191
             NGT   + Y +G++SG+LSQD ++V           GG+ V  Q+FGE T+ P + F+
Sbjct: 139 KHNGTELTLRYSTGTVSGFLSQDIITV-----------GGITV-TQMFGEVTEMPALPFM 186

Query: 192 AAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQP--GGELMLGG 249
            A+FDG++GM +   ++  V P+FDN++ Q ++ +++FSFY +RD +     GG+++LGG
Sbjct: 187 LAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGG 246

Query: 250 TDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVR 309
           +D ++Y+G+  Y+N+ +   WQ+ +  V V S   LC++GC A+VDTG S + G    + 
Sbjct: 247 SDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE 306

Query: 310 ELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSG 369
           +L +A+GA   +  +Y++ C +  TLP I+  LGGK Y L+  DY  + S + K LC   
Sbjct: 307 KLMEALGAKKRL-FDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLA 365

Query: 370 FMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEA 409
              MDIPPP+GP W LG  FI ++YT FDR NNR+GFA A
Sbjct: 366 IHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALA 405


>gi|4505757 progastricsin (pepsinogen C) [Homo sapiens]
          Length = 388

 Score =  289 bits (739), Expect = 4e-78
 Identities = 166/408 (40%), Positives = 233/408 (57%), Gaps = 31/408 (7%)

Query: 9   LALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAK--GPVSKYSQAVPAVTEGP 66
           + L  L    +A+V++PL KF SIR TM E G   E L      P  KY     +VT  P
Sbjct: 6   VVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEP 65

Query: 67  IPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSD 126
           +      YMDA Y+GEI IGTPPQ F V+FDTGSSNLWVPS++C+    AC  H ++N  
Sbjct: 66  MA-----YMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPS 118

Query: 127 KSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQP 186
           +SSTY  NG +F + YGSGSL+G+   DT++V             ++V  Q FG +  +P
Sbjct: 119 ESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQ-----------SIQVPNQEFGLSENEP 167

Query: 187 GITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELM 246
           G  F+ A+FDGI+G+AYP +SV+        ++Q+  +   +FS YLS +     GG ++
Sbjct: 168 GTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLS-NQQGSSGGAVV 226

Query: 247 LGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEV---ASGLTLCKEGCEAIVDTGTSLMVG 303
            GG DS  Y G + +  VT++ YWQ+ +++  +   ASG   C EGC+AIVDTGTSL+  
Sbjct: 227 FGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASG--WCSEGCQAIVDTGTSLLTV 284

Query: 304 PVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGK 363
           P   +  L +A GA     G++++ C  +  LP++T  + G  + L P  Y L    +  
Sbjct: 285 PQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYIL----SNN 340

Query: 364 TLCLSGFMGMDIPPPSG-PLWILGDVFIGRYYTVFDRDNNRVGFAEAA 410
             C  G     +   +G PLWILGDVF+  YY+V+D  NNRVGFA AA
Sbjct: 341 GYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA 388


>gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens]
          Length = 363

 Score =  215 bits (548), Expect = 5e-56
 Identities = 115/277 (41%), Positives = 163/277 (58%), Gaps = 14/277 (5%)

Query: 1   MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP 60
           M+   LL L L  L     +L R+PL +  S+++ +      + +      +        
Sbjct: 1   MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKL-RARSQLSEFWKSHNLDMIQFTES 59

Query: 61  AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH 120
              +    E L NY+D +Y+G I IG+PPQ FTV+FDTGSSNLWVPS++C     AC  H
Sbjct: 60  CSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCT--SPACKTH 117

Query: 121 HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG 180
            ++   +SSTY + G SF I YG+GSLSG +  D VSV            G+ V  Q FG
Sbjct: 118 SRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVE-----------GLTVVGQQFG 166

Query: 181 EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ 240
           E+  +PG TF+ A+FDGILG+ YP ++V  V PVFDN+M Q LVD  +FS Y+S +P+  
Sbjct: 167 ESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGG 226

Query: 241 PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQV 277
            G EL+ GG D  ++ GSL+++ VT++AYWQ+ LD +
Sbjct: 227 AGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNM 263


>gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprotein
           [Homo sapiens]
          Length = 518

 Score =  103 bits (258), Expect = 2e-22
 Identities = 102/358 (28%), Positives = 166/358 (46%), Gaps = 49/358 (13%)

Query: 79  YYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSF 138
           YY E+ IGTPPQ   ++ DTGSSN  V       +D        +++++SSTY   G   
Sbjct: 92  YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTY------FDTERSSTYRSKGFDV 145

Query: 139 DIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGI 198
            + Y  GS +G++ +D V++P     + S L  V +      E    PGI     K++GI
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIP--KGFNTSFL--VNIATIFESENFFLPGI-----KWNGI 196

Query: 199 LGMAYPRISV--NNVLPVFDNLMQQKLVDQNIFSFY-----LSRDPDAQPGGELMLGGTD 251
           LG+AY  ++   +++   FD+L+ Q  +  N+FS       L        GG L+LGG +
Sbjct: 197 LGLAYATLAKPSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIE 255

Query: 252 SKYYKGSLSYLNVTRKAYWQVHLDQVEVAS-GLTL-CKE--GCEAIVDTGTSLMVGP--- 304
              YKG + Y  +  + Y+Q+ + ++E+    L L C+E    +AIVD+GT+L+  P   
Sbjct: 256 PSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKV 315

Query: 305 VDEVRELQKAIGAVPLIQGEYMIPCEKV---------STLPAITLKL----GGKGYKLS- 350
            D V E       +P     +    +           S  P I++ L      + ++++ 
Sbjct: 316 FDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITI 375

Query: 351 -PEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFA 407
            P+ Y   +  AG       F    I P +  L ++G   +  +Y +FDR   RVGFA
Sbjct: 376 LPQLYIQPMMGAGLNYECYRF---GISPSTNAL-VIGATVMEGFYVIFDRAQKRVGFA 429


>gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprotein
           [Homo sapiens]
          Length = 468

 Score =  103 bits (257), Expect = 3e-22
 Identities = 96/340 (28%), Positives = 155/340 (45%), Gaps = 63/340 (18%)

Query: 79  YYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSF 138
           YY E+ IGTPPQ   ++ DTGSSN  V       +D        +++++SSTY   G   
Sbjct: 92  YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTY------FDTERSSTYRSKGFDV 145

Query: 139 DIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGI 198
            + Y  GS +G++ +D V++P     + S L  V +      E    PGI     K++GI
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIP--KGFNTSFL--VNIATIFESENFFLPGI-----KWNGI 196

Query: 199 LGMAYPRISV--NNVLPVFDNLMQQKLVDQNIFSFY-----LSRDPDAQPGGELMLGGTD 251
           LG+AY  ++   +++   FD+L+ Q  +  N+FS       L        GG L+LGG +
Sbjct: 197 LGLAYATLAKPSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIE 255

Query: 252 SKYYKGSLSYLNVTRKAYWQVHLDQVEV-ASGLTL-CKE--GCEAIVDTGTSLMVGPVDE 307
              YKG + Y  +  + Y+Q+ + ++E+    L L C+E    +AIVD+GT+L+  P   
Sbjct: 256 PSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKV 315

Query: 308 VRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCL 367
              + +A+    L+  + M+                  G  L+ E Y   +S        
Sbjct: 316 FDAVVEAVARASLLYIQPMM------------------GAGLNYECYRFGIS-------- 349

Query: 368 SGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFA 407
                     PS    ++G   +  +Y +FDR   RVGFA
Sbjct: 350 ----------PSTNALVIGATVMEGFYVIFDRAQKRVGFA 379


>gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprotein
           [Homo sapiens]
          Length = 501

 Score =  101 bits (251), Expect = 1e-21
 Identities = 106/368 (28%), Positives = 160/368 (43%), Gaps = 59/368 (16%)

Query: 79  YYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSF 138
           YY E+ +G+PPQ   ++ DTGSSN  V +     L      H  Y    SSTY       
Sbjct: 75  YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------HRYYQRQLSSTYRDLRKGV 128

Query: 139 DIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGI 198
            + Y  G   G L  D VS+P          G     R      T+        + ++GI
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPH---------GPNVTVRANIAAITESDKFFINGSNWEGI 179

Query: 199 LGMAYPRISV--NNVLPVFDNLMQQKLVDQNIFSFYL--------SRDPDAQPGGELMLG 248
           LG+AY  I+   +++ P FD+L++Q  V  N+FS  L          +  A  GG +++G
Sbjct: 180 LGLAYAEIARPDDSLEPFFDSLVKQTHVP-NLFSLQLCGAGFPLNQSEVLASVGGSMIIG 238

Query: 249 GTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTL---CKE--GCEAIVDTGTSLMVG 303
           G D   Y GSL Y  + R+ Y++V + +VE+ +G  L   CKE    ++IVD+GT+ +  
Sbjct: 239 GIDHSLYTGSLWYTPIRREWYYEVIIVRVEI-NGQDLKMDCKEYNYDKSIVDSGTTNLRL 297

Query: 304 PVDEVRELQKAIGAVPLIQ--------GEYMIPCEKVST-----LPAITLKLGGKGYKLS 350
           P        K+I A    +        GE ++ C +  T      P I+L L G+    S
Sbjct: 298 PKKVFEAAVKSIKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQS 356

Query: 351 ------PEDYTLKVSQAGKTL--CLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNN 402
                 P+ Y   V     +   C    +       S    ++G V +  +Y VFDR   
Sbjct: 357 FRITILPQQYLRPVEDVATSQDDCYKFAISQ-----SSTGTVMGAVIMEGFYVVFDRARK 411

Query: 403 RVGFAEAA 410
           R+GFA +A
Sbjct: 412 RIGFAVSA 419


>gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprotein
           [Homo sapiens]
          Length = 396

 Score = 96.3 bits (238), Expect = 5e-20
 Identities = 79/254 (31%), Positives = 128/254 (50%), Gaps = 27/254 (10%)

Query: 79  YYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSF 138
           YY E+ IGTPPQ   ++ DTGSSN  V       +D        +++++SSTY   G   
Sbjct: 92  YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTY------FDTERSSTYRSKGFDV 145

Query: 139 DIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGI 198
            + Y  GS +G++ +D V++P     + S L  V +      E    PGI     K++GI
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIP--KGFNTSFL--VNIATIFESENFFLPGI-----KWNGI 196

Query: 199 LGMAYPRISV--NNVLPVFDNLMQQKLVDQNIFSFY-----LSRDPDAQPGGELMLGGTD 251
           LG+AY  ++   +++   FD+L+ Q  +  N+FS       L        GG L+LGG +
Sbjct: 197 LGLAYATLAKPSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIE 255

Query: 252 SKYYKGSLSYLNVTRKAYWQVHLDQVEV-ASGLTL-CKE--GCEAIVDTGTSLMVGPVDE 307
              YKG + Y  +  + Y+Q+ + ++E+    L L C+E    +AIVD+GT+L+  P   
Sbjct: 256 PSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKV 315

Query: 308 VRELQKAIGAVPLI 321
              + +A+    LI
Sbjct: 316 FDAVVEAVARASLI 329


>gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprotein
           [Homo sapiens]
          Length = 476

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 98/358 (27%), Positives = 148/358 (41%), Gaps = 64/358 (17%)

Query: 79  YYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSF 138
           YY E+ +G+PPQ   ++ DTGSSN  V +     L      H  Y    SSTY       
Sbjct: 75  YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------HRYYQRQLSSTYRDLRKGV 128

Query: 139 DIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGI 198
            + Y  G   G L  D VS+P          G     R      T+        + ++GI
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPH---------GPNVTVRANIAAITESDKFFINGSNWEGI 179

Query: 199 LGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGS 258
           LG+AY  I+   +      L Q +++              A  GG +++GG D   Y GS
Sbjct: 180 LGLAYAEIA--RLCGAGFPLNQSEVL--------------ASVGGSMIIGGIDHSLYTGS 223

Query: 259 LSYLNVTRKAYWQVHLDQVEVASGLTL---CKE--GCEAIVDTGTSLMVGPVDEVRELQK 313
           L Y  + R+ Y++V + +VE+ +G  L   CKE    ++IVD+GT+ +  P        K
Sbjct: 224 LWYTPIRREWYYEVIIVRVEI-NGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVK 282

Query: 314 AIGAVPLIQ--------GEYMIPCEKVST-----LPAITLKLGGKGYKLS------PEDY 354
           +I A    +        GE ++ C +  T      P I+L L G+    S      P+ Y
Sbjct: 283 SIKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQY 341

Query: 355 TLKVSQAGKTL--CLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAA 410
              V     +   C    +       S    ++G V +  +Y VFDR   R+GFA +A
Sbjct: 342 LRPVEDVATSQDDCYKFAISQ-----SSTGTVMGAVIMEGFYVVFDRARKRIGFAVSA 394


>gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprotein
           [Homo sapiens]
          Length = 457

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 99/366 (27%), Positives = 147/366 (40%), Gaps = 99/366 (27%)

Query: 79  YYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSF 138
           YY E+ +G+PPQ   ++ DTGSSN  V +     L      H  Y    SSTY       
Sbjct: 75  YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------HRYYQRQLSSTYR------ 122

Query: 139 DIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGI 198
           D+  G            V VP                              +   K++G 
Sbjct: 123 DLRKG------------VYVP------------------------------YTQGKWEGE 140

Query: 199 LGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYL--------SRDPDAQPGGELMLGGT 250
           LG   P  S+    P FD+L++Q  V  N+FS  L          +  A  GG +++GG 
Sbjct: 141 LGTDLPDDSLE---PFFDSLVKQTHVP-NLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI 196

Query: 251 DSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTL---CKE--GCEAIVDTGTSLMVGPV 305
           D   Y GSL Y  + R+ Y++V + +VE+ +G  L   CKE    ++IVD+GT+ +  P 
Sbjct: 197 DHSLYTGSLWYTPIRREWYYEVIIVRVEI-NGQDLKMDCKEYNYDKSIVDSGTTNLRLPK 255

Query: 306 DEVRELQKAIGAVPLIQ--------GEYMIPCEKVST-----LPAITLKLGGKGYKLS-- 350
                  K+I A    +        GE ++ C +  T      P I+L L G+    S  
Sbjct: 256 KVFEAAVKSIKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFR 314

Query: 351 ----PEDYTLKVSQAGKTL--CLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRV 404
               P+ Y   V     +   C    +       S    ++G V +  +Y VFDR   R+
Sbjct: 315 ITILPQQYLRPVEDVATSQDDCYKFAISQ-----SSTGTVMGAVIMEGFYVVFDRARKRI 369

Query: 405 GFAEAA 410
           GFA +A
Sbjct: 370 GFAVSA 375


>gi|169218035 PREDICTED: similar to pepsinogen 3, group I [Homo
           sapiens]
          Length = 87

 Score = 68.9 bits (167), Expect = 8e-12
 Identities = 31/73 (42%), Positives = 43/73 (58%)

Query: 286 CKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGK 345
           C EGC+AIVDTGTSL+ GP   +  +Q  IGA     G+ ++ C  +S+LP I   + G 
Sbjct: 8   CAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGV 67

Query: 346 GYKLSPEDYTLKV 358
            Y + P  Y L+V
Sbjct: 68  QYPVPPSAYILQV 80


>gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprotein
           [Homo sapiens]
          Length = 432

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 57/198 (28%), Positives = 89/198 (44%), Gaps = 33/198 (16%)

Query: 239 AQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTL---CKE--GCEAI 293
           A  GG +++GG D   Y GSL Y  + R+ Y++V + +VE+ +G  L   CKE    ++I
Sbjct: 160 ASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEI-NGQDLKMDCKEYNYDKSI 218

Query: 294 VDTGTSLMVGPVDEVRELQKAIGAVPLIQ--------GEYMIPCEKVST-----LPAITL 340
           VD+GT+ +  P        K+I A    +        GE ++ C +  T      P I+L
Sbjct: 219 VDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISL 277

Query: 341 KLGGKGYKLS------PEDYTLKVSQAGKTL--CLSGFMGMDIPPPSGPLWILGDVFIGR 392
            L G+    S      P+ Y   V     +   C    +       S    ++G V +  
Sbjct: 278 YLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQ-----SSTGTVMGAVIMEG 332

Query: 393 YYTVFDRDNNRVGFAEAA 410
           +Y VFDR   R+GFA +A
Sbjct: 333 FYVVFDRARKRIGFAVSA 350



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 29/96 (30%), Positives = 41/96 (42%), Gaps = 9/96 (9%)

Query: 79  YYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSF 138
           YY E+ +G+PPQ   ++ DTGSSN  V +     L      H  Y    SSTY       
Sbjct: 75  YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------HRYYQRQLSSTYRDLRKGV 128

Query: 139 DIHYGSGSLSGYLSQDTV---SVPCQSASSASALGG 171
            + Y  G   G L  D +     P   +   +++GG
Sbjct: 129 YVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGG 164


>gi|63003930 transmembrane protein 30B [Homo sapiens]
          Length = 351

 Score = 32.0 bits (71), Expect = 1.1
 Identities = 28/98 (28%), Positives = 39/98 (39%), Gaps = 11/98 (11%)

Query: 319 PLIQGEYMIPCEKVSTLPAITLKLG----GKGYKLSPEDYTLKVSQAGKTLCLSGFMGMD 374
           PL+     +P    + L  I L LG      G K    DYT        ++C +   G  
Sbjct: 28  PLLSASIALPLFFCAGLAFIGLGLGLYYSSNGIKELEYDYTGDPGTGNCSVCAAAGQGRA 87

Query: 375 IPPPSGPLWI--LGDVFIGRYY-----TVFDRDNNRVG 405
           +PPP    W   L ++F G  Y     T F ++N R G
Sbjct: 88  LPPPCSCAWYFSLPELFQGPVYLYYELTNFYQNNRRYG 125


>gi|93141016 motile sperm domain containing 3 isoform b [Homo
           sapiens]
          Length = 225

 Score = 28.9 bits (63), Expect = 8.9
 Identities = 26/99 (26%), Positives = 41/99 (41%), Gaps = 11/99 (11%)

Query: 44  EDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNL 103
           ++L+  GP  + S+  P    GP+  VL    D  +  +   G P Q  T+   TG++  
Sbjct: 9   QELVGPGPPGRGSRGAPPPL-GPVVPVLVFPPDLVFRADQRSG-PRQLLTLYNPTGTALR 66

Query: 104 WVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHY 142
           +          + C    KY    +  YVK  +  DIHY
Sbjct: 67  F---------RVLCTAPAKYTVFDAEGYVKPQSCIDIHY 96


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,405,457
Number of Sequences: 37866
Number of extensions: 750505
Number of successful extensions: 1518
Number of sequences better than 10.0: 19
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 1440
Number of HSP's gapped (non-prelim): 23
length of query: 412
length of database: 18,247,518
effective HSP length: 105
effective length of query: 307
effective length of database: 14,271,588
effective search space: 4381377516
effective search space used: 4381377516
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.