Search of human proteins with 42716291

Search of human proteins with 42716291

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|42716291 erythrocyte membrane protein band 4.1
(elliptocytosis 1, RH-linked) isoform 2 [Homo sapiens]
         (641 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi...  1282   0.0  
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis...  1150   0.0  
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi...  1093   0.0  
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ...   620   e-177
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform...   580   e-165
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor...   536   e-152
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor...   536   e-152
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform...   526   e-149
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s...   525   e-149
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho...   299   5e-81
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s...   274   2e-73
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform...   261   1e-69
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo...   258   2e-68
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo...   258   2e-68
gi|117500790 FERM domain containing 3 [Homo sapiens]                  256   6e-68
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]        253   3e-67
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]         245   8e-65
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...   243   4e-64
gi|34916000 FERM domain containing 7 [Homo sapiens]                   234   2e-61
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i...   224   2e-58
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i...   222   9e-58
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i...   158   2e-38
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ...   156   5e-38
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i...   156   6e-38
gi|161702986 ezrin [Homo sapiens]                                     152   9e-37
gi|21614499 ezrin [Homo sapiens]                                      152   9e-37
gi|4505257 moesin [Homo sapiens]                                      145   1e-34
gi|4506467 radixin [Homo sapiens]                                     137   3e-32
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]                  126   5e-29
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]                  126   5e-29

>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 2 [Homo sapiens]
          Length = 641

 Score = 1282 bits (3318), Expect = 0.0
 Identities = 641/641 (100%), Positives = 641/641 (100%)

Query: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
           MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK
Sbjct: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60

Query: 61  EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
           EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG
Sbjct: 61  EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120

Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
           SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180

Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
           AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240

Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
           KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300

Query: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
           SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV
Sbjct: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360

Query: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSN 420
           AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSN
Sbjct: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSN 420

Query: 421 GDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSE 480
           GDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSE
Sbjct: 421 GDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSE 480

Query: 481 WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK 540
           WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK
Sbjct: 481 WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK 540

Query: 541 TITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVIT 600
           TITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVIT
Sbjct: 541 TITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVIT 600

Query: 601 GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 641
           GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE
Sbjct: 601 GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 641


>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
           RH-linked) isoform 3 [Homo sapiens]
          Length = 588

 Score = 1150 bits (2975), Expect = 0.0
 Identities = 588/641 (91%), Positives = 588/641 (91%), Gaps = 53/641 (8%)

Query: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
           MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK
Sbjct: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60

Query: 61  EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
           EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG
Sbjct: 61  EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120

Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
           SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180

Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
           AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240

Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
           KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300

Query: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
           SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV
Sbjct: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360

Query: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSN 420
           AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK              
Sbjct: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK-------------- 406

Query: 421 GDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSE 480
                KKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSE
Sbjct: 407 -----KKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSE 461

Query: 481 WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK 540
           WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK
Sbjct: 462 WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK 521

Query: 541 TITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVIT 600
           TITYEAAQT                                  VKGGISETRIEKRIVIT
Sbjct: 522 TITYEAAQT----------------------------------VKGGISETRIEKRIVIT 547

Query: 601 GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 641
           GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE
Sbjct: 548 GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 588


>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 1 [Homo sapiens]
          Length = 775

 Score = 1093 bits (2826), Expect = 0.0
 Identities = 566/641 (88%), Positives = 566/641 (88%), Gaps = 75/641 (11%)

Query: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
           MHCKVSLLDDTVYECVVE                                   TWLDSAK
Sbjct: 210 MHCKVSLLDDTVYECVVE-----------------------------------TWLDSAK 234

Query: 61  EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
           EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG
Sbjct: 235 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 294

Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
           SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN
Sbjct: 295 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 354

Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
           AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI
Sbjct: 355 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 414

Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
           KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY
Sbjct: 415 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 474

Query: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
           SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV
Sbjct: 475 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 534

Query: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSN 420
           AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK              
Sbjct: 535 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK-------------- 580

Query: 421 GDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSE 480
                                     DLDKSQEEIKKHHASISELKKNFMESVPEPRPSE
Sbjct: 581 --------------------------DLDKSQEEIKKHHASISELKKNFMESVPEPRPSE 614

Query: 481 WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK 540
           WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK
Sbjct: 615 WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK 674

Query: 541 TITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVIT 600
           TITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVIT
Sbjct: 675 TITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVIT 734

Query: 601 GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 641
           GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE
Sbjct: 735 GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 775


>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
           [Homo sapiens]
          Length = 1005

 Score =  620 bits (1598), Expect = e-177
 Identities = 348/683 (50%), Positives = 443/683 (64%), Gaps = 85/683 (12%)

Query: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
           + CKV+LLD T Y C +EKHAKGQ L  +VCEHLNLLE+DYFGL   ++   K WLD AK
Sbjct: 218 VQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAK 277

Query: 61  EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
           EIK+Q+R +PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLG
Sbjct: 278 EIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLG 337

Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
           SYT+Q+ELGDYDPE HG   +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLEN
Sbjct: 338 SYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLEN 397

Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
           AK+LSMYGVDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+I
Sbjct: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457

Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
           K+RP E EQ+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S +  PK+KFL LGSKFRY
Sbjct: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRY 517

Query: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT-- 356
           SGRTQAQTRQAS LIDRPAPHFERT+SKR SRSLDGA    +D +     P +A  I+  
Sbjct: 518 SGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAY 577

Query: 357 -QGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVT 415
             G V+   V D   ++ V                          PT+A      H+++ 
Sbjct: 578 GPGLVSIAVVQDGDGRREV------------------------RSPTKA-----PHLQLI 608

Query: 416 VPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPE 475
                  + +K   R++G+NIY+RHSNLMLE+LDK+QE+I KH ASISELK+NFMES PE
Sbjct: 609 -------EGKKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTPE 661

Query: 476 PRPSEWDKRLST-------HSPFRTLNI--------------------NG-QIPTGEGP- 506
           PRP+EW+KR  T        S   TLNI                    NG +I  G GP 
Sbjct: 662 PRPNEWEKRRITPLSLQTQGSSHETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGPG 721

Query: 507 ------PLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGV 560
                 P+ +  + ++S  +++  SE   +DV       +       +  +   +++   
Sbjct: 722 EIRKVEPVTQKDSTSLSSESSSSSSESEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEEP 781

Query: 561 LLTAQTITSE--TPSSTTTTQITKTVKGGISETRIEKRI---VITGDADIDHDQVLVQAI 615
              A+ +  E   P ++  TQ   +V     ET I++ +    I G+  + H+  L Q +
Sbjct: 782 RPAAKVVEREEAVPEASPVTQAGASVI--TVETVIQENVGAQKIPGEKSV-HEGALKQDM 838

Query: 616 KEAKEQHPDMSVTKVVVHQETEI 638
            E  E+ P   V   V H + ++
Sbjct: 839 GEEAEEEP-QKVNGEVSHVDIDV 860



 Score =  195 bits (496), Expect = 9e-50
 Identities = 124/255 (48%), Positives = 160/255 (62%), Gaps = 19/255 (7%)

Query: 387  VKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLE 446
            +++E E  E+ E EP  A KV +   E  VP ++   TQ     +  E +   +      
Sbjct: 767  IREEQEYEEEVEEEPRPAAKVVER--EEAVPEAS-PVTQAGASVITVETVIQENVGAQKI 823

Query: 447  DLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGP 506
              +KS  E          LK++  E   E       ++++       +++  QI     P
Sbjct: 824  PGEKSVHE--------GALKQDMGEEAEEE-----PQKVNGEVSHVDIDVLPQIICCSEP 870

Query: 507  PLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQT 566
            P+VKT+ VTISD +   ++EI TK+VPIV TETKTITYE+ Q D  +G  D G LLTAQT
Sbjct: 871  PVVKTEMVTISDASQ--RTEISTKEVPIVQTETKTITYESPQIDGGAGG-DSGTLLTAQT 927

Query: 567  ITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMS 626
            ITSE+ S+TTTT ITKTVKGGISETRIEKRIVITGD DIDHDQ L QAI+EA+EQHPDMS
Sbjct: 928  ITSESVSTTTTTHITKTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMS 987

Query: 627  VTKVVVHQETEIADE 641
            VT+VVVH+ETE+A+E
Sbjct: 988  VTRVVVHKETELAEE 1002


>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
           [Homo sapiens]
          Length = 779

 Score =  580 bits (1494), Expect = e-165
 Identities = 357/748 (47%), Positives = 444/748 (59%), Gaps = 123/748 (16%)

Query: 3   CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEI 62
           C+V+LLD + YEC VEKH +GQ L   VCEHLNLLE+DYFGL   D  + K WLD +KEI
Sbjct: 37  CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 96

Query: 63  KKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSY 122
           KKQ+R  PWNF F VKFYPPDPAQLTEDITRYYLCLQLR DI+ GRLPCSF T ALLGSY
Sbjct: 97  KKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 156

Query: 123 TIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAK 182
            +Q+ELGDYD E H  +YVS+ + APNQT+ELEE++MELHK+YR MTP +A++ FLENAK
Sbjct: 157 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 216

Query: 183 KLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKI 242
           KLSMYGVDLH AKD EG+DI+LGVC++GLL+Y+D+LRINRF WPK+LKISYKRS+F+IKI
Sbjct: 217 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 276

Query: 243 RPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSG 302
           RPGE EQ+ESTIGFKLP++R+AK+LWKVC+EHHTFFRL S +  PK  FL +GSKFRYSG
Sbjct: 277 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSKFRYSG 335

Query: 303 RTQAQTRQASALIDRPAPHFERTASKR--ASRSLDG------AAAVDSADRSP----RPT 350
           RTQAQTRQASALIDRPAP FER++SKR   SRSLDG      A+  ++ D  P    R  
Sbjct: 336 RTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDE 395

Query: 351 SAPAITQGQVAEGGVLDASAK----------KTVVPKAQ------KETVKAEVKK----- 389
              +  Q   AE G +    K          + V+ K Q      K T+K    K     
Sbjct: 396 DGESGGQRSEAEEGEVRTPTKIKELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRD 455

Query: 390 ---EDE---PPEQAEPEP--------TEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGE- 434
              E E   P   A P P          A   E +  +V  P     ++    E  D E 
Sbjct: 456 RDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQER 515

Query: 435 -NIYIRHSNLMLE--------------DLDKSQEEIKKHHASISELKKNFMESVPEPRPS 479
             ++++ ++L +E              + +     I  +H S  E   +F  S+PE    
Sbjct: 516 DTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFE---DFSRSLPELDRD 572

Query: 480 EWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVP---IVH 536
           + D         R LN        +G P    ++  I D+ +  +    T D+P    V 
Sbjct: 573 KSDSDTEGLLFSRDLN--------KGAPSQDDESGGIEDSPD--RGACSTPDMPQFEPVK 622

Query: 537 TETKTITYEAAQ------------------TDDNS-------GDLDPGVLLTAQTITSET 571
           TET T++  A +                  T +NS         + PG    A  I S +
Sbjct: 623 TETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQENSLKSGKGAAAMIPGPQTVATEIRSLS 682

Query: 572 P--------------SSTTTTQIT----KTVKGGISETRIEKRIVITGDADIDHDQVLVQ 613
           P              + T +T  T    KTVKGG SETRIEKRI+ITGD D+D DQ L  
Sbjct: 683 PIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALAL 742

Query: 614 AIKEAKEQHPDMSVTKVVVHQETEIADE 641
           AIKEAK QHPDM VTK VV++ET+ + E
Sbjct: 743 AIKEAKLQHPDMLVTKAVVYRETDPSPE 770


>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score =  536 bits (1380), Expect = e-152
 Identities = 263/379 (69%), Positives = 310/379 (81%), Gaps = 5/379 (1%)

Query: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
           + CKV+LLD T Y C +EKHAKGQ L  +VCEHLNLLE+DYFGL   ++   K WLD AK
Sbjct: 218 VQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAK 277

Query: 61  EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
           EIK+Q+R +PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLG
Sbjct: 278 EIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLG 337

Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
           SYT+Q+ELGDYDPE HG   +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLEN
Sbjct: 338 SYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLEN 397

Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
           AK+LSMYGVDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+I
Sbjct: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457

Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
           K+RP E EQ+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S +  PK+KFL LGSKFRY
Sbjct: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRY 517

Query: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT-- 356
           SGRTQAQTRQAS LIDRPAPHFERT+SKR SRSLDGA    +D +     P +A  I+  
Sbjct: 518 SGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAY 577

Query: 357 -QGQVAEGGVLDASAKKTV 374
             G V+   V D   ++ V
Sbjct: 578 GPGLVSIAVVQDGDGRREV 596



 Score =  107 bits (267), Expect = 3e-23
 Identities = 51/60 (85%), Positives = 57/60 (95%)

Query: 582 KTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 641
           KTVKGGISETRIEKRIVITGD DIDHDQ L QAI+EA+EQHPDMSVT+VVVH+ETE+A+E
Sbjct: 611 KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 670


>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score =  536 bits (1380), Expect = e-152
 Identities = 263/379 (69%), Positives = 310/379 (81%), Gaps = 5/379 (1%)

Query: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
           + CKV+LLD T Y C +EKHAKGQ L  +VCEHLNLLE+DYFGL   ++   K WLD AK
Sbjct: 218 VQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAK 277

Query: 61  EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
           EIK+Q+R +PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLG
Sbjct: 278 EIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLG 337

Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
           SYT+Q+ELGDYDPE HG   +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLEN
Sbjct: 338 SYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLEN 397

Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
           AK+LSMYGVDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+I
Sbjct: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457

Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
           K+RP E EQ+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S +  PK+KFL LGSKFRY
Sbjct: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRY 517

Query: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT-- 356
           SGRTQAQTRQAS LIDRPAPHFERT+SKR SRSLDGA    +D +     P +A  I+  
Sbjct: 518 SGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAY 577

Query: 357 -QGQVAEGGVLDASAKKTV 374
             G V+   V D   ++ V
Sbjct: 578 GPGLVSIAVVQDGDGRREV 596



 Score =  107 bits (267), Expect = 3e-23
 Identities = 51/60 (85%), Positives = 57/60 (95%)

Query: 582 KTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 641
           KTVKGGISETRIEKRIVITGD DIDHDQ L QAI+EA+EQHPDMSVT+VVVH+ETE+A+E
Sbjct: 611 KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 670


>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
           [Homo sapiens]
          Length = 881

 Score =  526 bits (1355), Expect = e-149
 Identities = 284/509 (55%), Positives = 342/509 (67%), Gaps = 60/509 (11%)

Query: 3   CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEI 62
           C+V+LLD + YEC VEKH +GQ L   VCEHLNLLE+DYFGL   D  + K WLD +KEI
Sbjct: 99  CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 158

Query: 63  KKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSY 122
           KKQ+R  PWNF F VKFYPPDPAQLTEDITRYYLCLQLR DI+ GRLPCSF T ALLGSY
Sbjct: 159 KKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 218

Query: 123 TIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAK 182
            +Q+ELGDYD E H  +YVS+ + APNQT+ELEE++MELHK+YR MTP +A++ FLENAK
Sbjct: 219 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 278

Query: 183 KLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKI 242
           KLSMYGVDLH AKD EG+DI+LGVC++GLL+Y+D+LRINRF WPK+LKISYKRS+F+IKI
Sbjct: 279 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 338

Query: 243 RPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSG 302
           RPGE EQ+ESTIGFKLP++R+AK+LWKVC+EHHTFFRL S +  PK  FL +GSKFRYSG
Sbjct: 339 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSKFRYSG 397

Query: 303 RTQAQTRQASALIDRPAPHFERTASKR--ASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
           RTQAQTRQASALIDRPAP FER++SKR   SRSLDGA          RP S         
Sbjct: 398 RTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGA-------EFSRPASV-------- 442

Query: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSN 420
                            ++      +  K DE  E          + E    EV  PT  
Sbjct: 443 -----------------SENHDAGPDGDKRDEDGESG------GQRSEAEEGEVRTPT-- 477

Query: 421 GDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFME--SVPEPRP 478
                K +E    +    RH     E LDK ++ + KH ASI+ELK+   E  S    R 
Sbjct: 478 -----KIKELKPEQETTPRHKQ---EFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRD 529

Query: 479 SEWDKRLSTHSPFRTLNINGQIPTGEGPP 507
            +W++        R L  +   P+ +G P
Sbjct: 530 RDWERE-------RRLPSSPASPSPKGTP 551



 Score =  107 bits (266), Expect = 4e-23
 Identities = 77/196 (39%), Positives = 105/196 (53%), Gaps = 23/196 (11%)

Query: 453 EEIKKHHASISEL---KKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEG---- 505
           E +K    ++S L   KK   E+V + R S  D          T  ++G    G      
Sbjct: 693 EPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDN---------TQQVDGSASVGREFIAT 743

Query: 506 PPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQ 565
            P + T+T++ +   N++KS    K    +    +T+  E        G     VL +  
Sbjct: 744 TPSITTETISTTME-NSLKSG---KGAAAMIPGPQTVATEIRSLSPIIGK---DVLTSTY 796

Query: 566 TITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDM 625
             T+ET S++TTT +TKTVKGG SETRIEKRI+ITGD D+D DQ L  AIKEAK QHPDM
Sbjct: 797 GATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDM 856

Query: 626 SVTKVVVHQETEIADE 641
            VTK VV++ET+ + E
Sbjct: 857 LVTKAVVYRETDPSPE 872


>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
           sapiens]
          Length = 1087

 Score =  525 bits (1352), Expect = e-149
 Identities = 266/401 (66%), Positives = 313/401 (78%), Gaps = 19/401 (4%)

Query: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
           M CKV LLD + Y C VEK ++GQ L  +VCEHLNLLE+DYFGL   D    K WLD AK
Sbjct: 110 MQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAK 169

Query: 61  EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
           EIKKQVR   W+F+FNVKFYPPDPAQL+EDITRYYLCLQLR DIV+GRLPCSF TLALLG
Sbjct: 170 EIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLG 229

Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
           SYT+QSELGDYDP+  G DY+S+F+ APN TKELE+KV+ELHKS+R MTPA+A++ FLEN
Sbjct: 230 SYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLEN 289

Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
           AKKLSMYGVDLH AKD EGV+I+LGVC+SGLL+Y+D+LRINRF WPKVLKISYKR++F+I
Sbjct: 290 AKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYI 349

Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
           KIRPGE EQ+ESTIGFKLP++RAAK+LWKVCVEHHTFFRL   +  PK KFL LGSKFRY
Sbjct: 350 KIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPK-KFLTLGSKFRY 408

Query: 301 SGRTQAQTRQASALIDRPAPHFERTASKR--ASRSLDGAAAVDSADRSPRPTSAPAITQG 358
           SGRTQAQTR+ASALIDRPAP+FER++SKR   SRSLDG             T   A T+ 
Sbjct: 409 SGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVG----------TGQYATTK- 457

Query: 359 QVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEP 399
                G+   +   TV P+ + E  + E + +    E+  P
Sbjct: 458 -----GISQTNLITTVTPEKKAEEERDEEEDKRRKGEEVTP 493



 Score =  195 bits (495), Expect = 1e-49
 Identities = 102/134 (76%), Positives = 116/134 (86%), Gaps = 2/134 (1%)

Query: 509  VKTQTVTI-SDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTI 567
            VKT+T++  S +   VK EI TK+VP+VHTETKTITYE++Q D  + DL+PGVL++AQTI
Sbjct: 951  VKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGT-DLEPGVLMSAQTI 1009

Query: 568  TSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSV 627
            TSET S+TTTT ITKTVKGGISETRIEKRIVITGDADIDHDQ L QAIKEAKEQHPDMSV
Sbjct: 1010 TSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSV 1069

Query: 628  TKVVVHQETEIADE 641
            TKVVVH+ETEI  E
Sbjct: 1070 TKVVVHKETEITPE 1083



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 40/121 (33%), Positives = 62/121 (51%), Gaps = 11/121 (9%)

Query: 408 EKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKK 467
           E+T  E T   ++G+ T  + ++ +        + L  ++L+K+Q+++ KH  +ISELK+
Sbjct: 688 EETDSERTDTAADGETTATESDQEED-------AELKAQELEKTQDDLMKHQTNISELKR 740

Query: 468 NFME-SVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSE 526
            F+E S      +EW+KRLST SP R        P  E  PLV  +T   S       SE
Sbjct: 741 TFLETSTDTAVTNEWEKRLST-SPVRLAARQEDAPMIE--PLVPEETKQSSGEKLMDGSE 797

Query: 527 I 527
           I
Sbjct: 798 I 798


>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
           sapiens]
          Length = 926

 Score =  299 bits (766), Expect = 5e-81
 Identities = 154/338 (45%), Positives = 218/338 (64%), Gaps = 7/338 (2%)

Query: 3   CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKT-WLDSAKE 61
           C + LLD+TV    V KH +GQ LL  V +HL+L E+DYFGL + D++T    WLD  K 
Sbjct: 31  CNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKP 90

Query: 62  IKKQV-RGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
           I+KQ+ RG P++  F VKF+  DP +L E+ TRY   LQ++QDI+ GRLPC   T ALL 
Sbjct: 91  IRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLA 150

Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
           S+ +QSELGDYD   +   Y+SD+   PNQ ++ E+++ +LH+ +  ++PA+A+  +L  
Sbjct: 151 SFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNT 210

Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
           A+ L +YGV+ H A+D    +I++GV S G+L+YK+++R+N FPW K++KIS+K   FFI
Sbjct: 211 ARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFI 270

Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLA----LGS 296
           ++R    E  E+ +GF + +YRA K LWK CVEHHTFFRL      P+  F A    LGS
Sbjct: 271 QLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRL-DRPLPPQKNFFAHYFTLGS 329

Query: 297 KFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSL 334
           KFRY GRT+ Q+ Q           F R+ SK  +R L
Sbjct: 330 KFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKL 367


>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
           sapiens]
          Length = 733

 Score =  274 bits (701), Expect = 2e-73
 Identities = 146/335 (43%), Positives = 204/335 (60%), Gaps = 7/335 (2%)

Query: 3   CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEI 62
           C+VSLLD T     + K AKGQ+L  ++  HL+L+E DYFGL   D+A    WLD  K I
Sbjct: 45  CRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSI 104

Query: 63  KKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGS 121
           KKQV+ G P+     VKFY  +P  L E++TRY   LQL+QDI++G+L C F T   L +
Sbjct: 105 KKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQLAA 164

Query: 122 YTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENA 181
           Y +Q+ELGDYD   H  + VS+F+  P QT+E+E  + E  K YR  TPAQA+  +L  A
Sbjct: 165 YNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLNKA 224

Query: 182 KKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIK 241
           K L MYGVD+H  K  +G D  LG+  +G+LV++   +I  F WPK+ ++ +K++   + 
Sbjct: 225 KWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKLTLV 284

Query: 242 IRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTIPKSKFLALGSK 297
           +   + +  + E T  F+L   +A K LWK  VEHH FFRL      +  +S F+ LGS+
Sbjct: 285 VVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSHRSGFIRLGSR 344

Query: 298 FRYSGRTQAQTRQASALIDRPAPHFERTASKRASR 332
           FRYSG+T+ QT + +    R +  FER  SKR SR
Sbjct: 345 FRYSGKTEYQTTKTNKA--RRSTSFERRPSKRYSR 377


>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
           [Homo sapiens]
          Length = 1045

 Score =  261 bits (667), Expect = 1e-69
 Identities = 150/362 (41%), Positives = 208/362 (57%), Gaps = 5/362 (1%)

Query: 4   KVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIK 63
           K+ +LDDT     V + A G+ LL  VC HLNL+E DYFGL   D+     WLD  K I 
Sbjct: 43  KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIV 102

Query: 64  KQVRGVPWNFT-FNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSY 122
           KQ+R        F VKF+PPD  QL E++TRY   LQ++QD+  GRL C+  + ALL S+
Sbjct: 103 KQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISH 162

Query: 123 TIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAK 182
            +QSE+GD+D  L   ++++  K  P Q   LE+K++E H ++   TPA++D + LE A+
Sbjct: 163 IVQSEIGDFDEALDR-EHLAKNKYIPQQDA-LEDKIVEFHHNHIGQTPAESDFQLLEIAR 220

Query: 183 KLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKI 242
           +L MYG+ LH AKD EG  I L V ++G+LV++   +IN F W KV K+S+KR  F IK+
Sbjct: 221 RLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKL 280

Query: 243 RPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRL-TSTDTIPKSKFLALGSKFRYS 301
           RP     Y+ T+ F + S    K  WK+CVEHH FFRL       PK    + GS FR+S
Sbjct: 281 RPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFS 340

Query: 302 GRTQAQTRQASALIDRPAPHFERTASK-RASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
           GRTQ Q              FER  SK  + RSL       +++   +   + ++T G+ 
Sbjct: 341 GRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEG 400

Query: 361 AE 362
           AE
Sbjct: 401 AE 402


>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
           1 [Homo sapiens]
          Length = 518

 Score =  258 bits (658), Expect = 2e-68
 Identities = 138/334 (41%), Positives = 199/334 (59%), Gaps = 7/334 (2%)

Query: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
           ++C+V LLD T     + KHAKGQDL  ++  HL+L+E DYFGL   D+A    WLD AK
Sbjct: 85  LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144

Query: 61  EIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
            IKKQ++ G  +   F VK+Y  +P  L E+ TRY   LQLR DI++G+L C + T   L
Sbjct: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204

Query: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179
            +  +Q+ELG+ +   H  + VS+F+  PNQT+ +E  + +  K  R  +PAQA+L +L 
Sbjct: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264

Query: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239
            AK L MYGVD+H  +  +G +  LG+  +G+L+++   +I  F WPK+ K+ +K+S   
Sbjct: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLT 324

Query: 240 IKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTIPKSKFLALG 295
           + +   + +  + E T  F+L S R  K LWK  VEHH FFRL +       +S F+ LG
Sbjct: 325 LVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLG 384

Query: 296 SKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 329
           S+FR+SGRT+ Q    S L  R    FER  SKR
Sbjct: 385 SRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416


>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
           2 [Homo sapiens]
          Length = 900

 Score =  258 bits (658), Expect = 2e-68
 Identities = 138/334 (41%), Positives = 199/334 (59%), Gaps = 7/334 (2%)

Query: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
           ++C+V LLD T     + KHAKGQDL  ++  HL+L+E DYFGL   D+A    WLD AK
Sbjct: 85  LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144

Query: 61  EIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
            IKKQ++ G  +   F VK+Y  +P  L E+ TRY   LQLR DI++G+L C + T   L
Sbjct: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204

Query: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179
            +  +Q+ELG+ +   H  + VS+F+  PNQT+ +E  + +  K  R  +PAQA+L +L 
Sbjct: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264

Query: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239
            AK L MYGVD+H  +  +G +  LG+  +G+L+++   +I  F WPK+ K+ +K+S   
Sbjct: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLT 324

Query: 240 IKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTIPKSKFLALG 295
           + +   + +  + E T  F+L S R  K LWK  VEHH FFRL +       +S F+ LG
Sbjct: 325 LVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLG 384

Query: 296 SKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 329
           S+FR+SGRT+ Q    S L  R    FER  SKR
Sbjct: 385 SRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416


>gi|117500790 FERM domain containing 3 [Homo sapiens]
          Length = 597

 Score =  256 bits (653), Expect = 6e-68
 Identities = 142/406 (34%), Positives = 225/406 (55%), Gaps = 12/406 (2%)

Query: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
           M C + LLDD+   C +++  KGQ L+  +C + +LLE+DYFG+   D    + WL+  K
Sbjct: 32  MRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNK 91

Query: 61  EIKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
            I KQ++   P+   F VKFYP +P ++ E++TRY L LQ+++DI  GRL CSF+  A L
Sbjct: 92  SIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYL 151

Query: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKS-YRSMTPAQADLEFL 178
           G+  +Q+ELGDYDP+ H  +Y+S+F++ P Q+++LE K++E+HK+  R  +P  A+   L
Sbjct: 152 GACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLL 211

Query: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSF 238
             A  L  YGVD H  KD  G    LG  ++G +V++   RI+   WP V K+ ++  +F
Sbjct: 212 LKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTF 271

Query: 239 FIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD---TIPKSKFLALG 295
           ++    G Q++ ++ + F   +  A K LWK  VE+  F++   +    T+  SK    G
Sbjct: 272 YV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKG 328

Query: 296 SKFRYSGRTQAQTRQASALIDRPAPHFERT--ASKRASRSLDGAAAVDSADRSPRPTSAP 353
           S+FRYSG+   +  +AS+ I R  P   R      R+S SL+    ++     P   S P
Sbjct: 329 SRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPS-P 387

Query: 354 AITQGQVAEG-GVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAE 398
           +  + ++  G GV     +    P      VKA  + ED P E+ +
Sbjct: 388 SEQEEELPLGEGVPLPKEENISAPLISSSPVKAAREYEDPPSEEED 433


>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
          Length = 686

 Score =  253 bits (647), Expect = 3e-67
 Identities = 152/409 (37%), Positives = 222/409 (54%), Gaps = 28/409 (6%)

Query: 2   HCKVSLLDD-----TVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWL 56
           +C+V LLD+     T  +  ++K  KG  +L  V  H+NL+E DYFGL   D +    WL
Sbjct: 12  YCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWL 71

Query: 57  DSAKEIKKQVR----GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCS 112
           D AK + +       G P+   F +KFY  DP +L E+ITRY   LQ++QD++ GRLPC 
Sbjct: 72  DPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCP 131

Query: 113 FATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQ 172
             T A LG+Y IQSELGDYDP  H   YVS+++  P+Q +ELEE +  +HK+     P++
Sbjct: 132 VNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSE 191

Query: 173 ADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKIS 232
           A+L +L  AK L MYGVDLH        +  LG+   G++VYK+K ++ ++ WP++ K+ 
Sbjct: 192 AELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVH 251

Query: 233 YKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD----TIPK 288
           +K + F  ++R   ++  E++  F+  S  A K LWK  VEHHTFFR+   +    +   
Sbjct: 252 FKETQF--ELRVLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSLSRKL 309

Query: 289 SKFLALGSKFRYSGRTQAQ-TRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSP 347
           SKF ++  K RYSGRT  Q +R  S  + RP  +  R+ SK   + +      +S     
Sbjct: 310 SKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYPKRIAQTQPAES----- 364

Query: 348 RPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQ 396
              S   IT     E G  + +  K + P   K   KA  K E+ P  Q
Sbjct: 365 --NSISRITANM--ENGENEGTI-KIIAPSPVKSFKKA--KNENSPDTQ 406


>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
          Length = 570

 Score =  245 bits (626), Expect = 8e-65
 Identities = 133/363 (36%), Positives = 202/363 (55%), Gaps = 9/363 (2%)

Query: 3   CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEI 62
           C V LLDD+ Y C +++ AKGQ L   +C HLNLLE+DYFG+   D    + WL+  K +
Sbjct: 19  CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78

Query: 63  KKQVRGVP-WNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGS 121
            KQ+R  P +   F VKFYP DPA L E+ITRY + LQ+++D+  GRL C  +  ALL +
Sbjct: 79  VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAA 138

Query: 122 YTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRS-MTPAQADLEFLEN 180
           Y +Q+E+GDYD   H   Y S F+  P  +++LE K+ E+HK+  S  TPA ++L FL  
Sbjct: 139 YILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRK 198

Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
           A+ L  YGVD H  KD+ G    L     G +V +   R++   W +V K+ ++  +F++
Sbjct: 199 AQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYL 258

Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD---TIPKSKFLALGSK 297
            +   ++E+ +  + +  P+  A K LWK  +E+  F++L  +    T+  S     GS+
Sbjct: 259 YV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSR 316

Query: 298 FRYSGRTQAQTRQASALIDRPAPHFERT--ASKRASRSLDGAAAVDSADRSPRPTSAPAI 355
           FRYSGR   +  ++SA I R  P   R      R+  S+     + S  R+ R     +I
Sbjct: 317 FRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHISI 376

Query: 356 TQG 358
            +G
Sbjct: 377 MEG 379


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
           sapiens]
          Length = 1054

 Score =  243 bits (620), Expect = 4e-64
 Identities = 137/311 (44%), Positives = 187/311 (60%), Gaps = 8/311 (2%)

Query: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
           +H +V LLD+T+    +E    GQ LL +V + LNL+E DYFG+   +  +   WL+  K
Sbjct: 44  LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMK 103

Query: 61  EIKKQVRGVPWNFTFN--VKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLAL 118
            I +Q+R  P N      VKF+PPDP QL E+ TRY   LQL++D++  RL C+  T AL
Sbjct: 104 PIIRQIRR-PKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAAL 162

Query: 119 LGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFL 178
           L S+ +QSE+GDYD  L   +++   +  P Q   LE K++E H+ +   TPA++D + L
Sbjct: 163 LTSHLLQSEIGDYDETLDR-EHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAESDFQVL 220

Query: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSF 238
           E A+KL MYG+  H A D EG  I L V   G+LV++   +IN F W KV K+S+KR  F
Sbjct: 221 EIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRF 280

Query: 239 FIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSK--FLALGS 296
            IK+ P     Y+ T+ F L S    K  WK+CVE+HTFFRL      PK+K  F + GS
Sbjct: 281 LIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPK-PKAKAVFFSRGS 339

Query: 297 KFRYSGRTQAQ 307
            FRYSGRTQ Q
Sbjct: 340 SFRYSGRTQKQ 350


>gi|34916000 FERM domain containing 7 [Homo sapiens]
          Length = 714

 Score =  234 bits (597), Expect = 2e-61
 Identities = 128/309 (41%), Positives = 182/309 (58%), Gaps = 4/309 (1%)

Query: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
           +H KV  LDD+    VV++ + G+ L    C HLNL E++YFGL    ++ +  WL+  K
Sbjct: 2   LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61

Query: 61  EIKKQVRGVPWN-FTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
            I KQV+      F F VKF+P DP  L E++TRY   LQ+++D+  GRLPCS    AL+
Sbjct: 62  PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121

Query: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179
            S+ +QSELGD+  E     +++  +  PNQ   LE K+M  H+ +   +PA++D+  L+
Sbjct: 122 VSHILQSELGDFHEETDR-KHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLD 179

Query: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239
            A+KL MYG+  H A D EG+ I L V   G+LV +   +IN F W K+ K+S+KR  F 
Sbjct: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239

Query: 240 IKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLT-STDTIPKSKFLALGSKF 298
           IK+        + T+ F + S  A K  WK CVE+H FFRL+    + PK+   + GS F
Sbjct: 240 IKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSF 299

Query: 299 RYSGRTQAQ 307
           RYSGRTQ Q
Sbjct: 300 RYSGRTQRQ 308


>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
           isoform 1 [Homo sapiens]
          Length = 913

 Score =  224 bits (570), Expect = 2e-58
 Identities = 137/438 (31%), Positives = 229/438 (52%), Gaps = 25/438 (5%)

Query: 3   CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNAT-SKTWLDSAKE 61
           C +  LD  V    V K   GQ LL  V  HL + E++YFGL   D++  S  WL+++K 
Sbjct: 31  CSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKA 90

Query: 62  IKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
           I+KQ++G  P    F V+F+ PDP  L ++ TR+   LQL+ DI  GRL C   +  +L 
Sbjct: 91  IRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLA 150

Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
           SY +QS  GDY+  +H   Y+SD    P+Q ++   KV  LH+ +  +  ++A+  ++  
Sbjct: 151 SYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINI 210

Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
           A+ L  YGV+LH  +DL  +D+++G+ S+G+ VY+  +  + +PW  +LKIS+KR  FFI
Sbjct: 211 ARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFI 270

Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---RLTSTDTIPKSKFLALGSK 297
             R  + E  E  + F + +YR+ K LWK CVEHHTFF   +L   +    S++  +GS+
Sbjct: 271 HQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSR 330

Query: 298 -FRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSAD----------RS 346
             + S   Q   +    ++  PA     +     ++SL   +   + +          R 
Sbjct: 331 NTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRK 390

Query: 347 PRPTSAPAITQGQ--VAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQ--AEPEPT 402
           PR +SA  +      + E   +  + K ++ P    +   +EV +   P ++  +E  P 
Sbjct: 391 PRHSSADNLANEMTYITETEDVFYTYKGSLAP----QDSDSEVSQNRSPHQESLSENNPA 446

Query: 403 EAWKVEKTHIEVTVPTSN 420
           +++  +K+   V+ P+SN
Sbjct: 447 QSYLTQKSSSSVS-PSSN 463


>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
           isoform 2 [Homo sapiens]
          Length = 868

 Score =  222 bits (565), Expect = 9e-58
 Identities = 113/300 (37%), Positives = 175/300 (58%), Gaps = 5/300 (1%)

Query: 3   CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNAT-SKTWLDSAKE 61
           C +  LD  V    V K   GQ LL  V  HL + E++YFGL   D++  S  WL+++K 
Sbjct: 31  CSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKA 90

Query: 62  IKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
           I+KQ++G  P    F V+F+ PDP  L ++ TR+   LQL+ DI  GRL C   +  +L 
Sbjct: 91  IRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLA 150

Query: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
           SY +QS  GDY+  +H   Y+SD    P+Q ++   KV  LH+ +  +  ++A+  ++  
Sbjct: 151 SYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINI 210

Query: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
           A+ L  YGV+LH  +DL  +D+++G+ S+G+ VY+  +  + +PW  +LKIS+KR  FFI
Sbjct: 211 ARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFI 270

Query: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---RLTSTDTIPKSKFLALGSK 297
             R  + E  E  + F + +YR+ K LWK CVEHHTFF   +L   +    S++  +GS+
Sbjct: 271 HQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSR 330


>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
           isoform 3 [Homo sapiens]
          Length = 782

 Score =  158 bits (399), Expect = 2e-38
 Identities = 97/336 (28%), Positives = 171/336 (50%), Gaps = 23/336 (6%)

Query: 103 DIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELH 162
           DI  GRL C   +  +L SY +QS  GDY+  +H   Y+SD    P+Q ++   KV  LH
Sbjct: 2   DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61

Query: 163 KSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINR 222
           + +  +  ++A+  ++  A+ L  YGV+LH  +DL  +D+++G+ S+G+ VY+  +  + 
Sbjct: 62  EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121

Query: 223 FPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---R 279
           +PW  +LKIS+KR  FFI  R  + E  E  + F + +YR+ K LWK CVEHHTFF   +
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181

Query: 280 LTSTDTIPKSKFLALGSK-FRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAA 338
           L   +    S++  +GS+  + S   Q   +    ++  PA     +     ++SL   +
Sbjct: 182 LLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRS 241

Query: 339 AVDSAD----------RSPRPTSAPAITQGQ--VAEGGVLDASAKKTVVPKAQKETVKAE 386
              + +          R PR +SA  +      + E   +  + K ++ P    +   +E
Sbjct: 242 PPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAP----QDSDSE 297

Query: 387 VKKEDEPPEQ--AEPEPTEAWKVEKTHIEVTVPTSN 420
           V +   P ++  +E  P +++  +K+   V+ P+SN
Sbjct: 298 VSQNRSPHQESLSENNPAQSYLTQKSSSSVS-PSSN 332


>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
           [Homo sapiens]
          Length = 1174

 Score =  156 bits (395), Expect = 5e-38
 Identities = 92/287 (32%), Positives = 149/287 (51%), Gaps = 16/287 (5%)

Query: 4   KVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIK 63
           ++ LL++   E  +   + GQ+ L+ V + L L E  YF L  ++    + W+D  K +K
Sbjct: 26  RIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLK 85

Query: 64  KQVRGVPWNFT--FNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGS 121
           KQ+       T  F V FY P  +QL ++ITRY   LQL++DI+ G +PC+      L  
Sbjct: 86  KQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAG 145

Query: 122 YTIQSELGDYDPELHGVDYVSDFKLAP----NQTKELEE---KVMELHKSYRSMTPAQAD 174
             +Q++ GD+D +    D++  F L P       K LEE   KV  LH+ YR +T   A+
Sbjct: 146 LAVQADFGDFD-QYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDAE 204

Query: 175 LEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLV-YKDKLRINRFPWPKVLKISY 233
           + +++  +++  YG + + AKD +G DI +G C  G+ V +K+      F W  +  +S+
Sbjct: 205 MLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSH 264

Query: 234 KRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRL 280
            +S F +     E    E TI F+      AK +W++CV  H F+RL
Sbjct: 265 NKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLCVARHKFYRL 306


>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
           isoform 4 [Homo sapiens]
          Length = 737

 Score =  156 bits (394), Expect = 6e-38
 Identities = 73/198 (36%), Positives = 117/198 (59%), Gaps = 3/198 (1%)

Query: 103 DIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELH 162
           DI  GRL C   +  +L SY +QS  GDY+  +H   Y+SD    P+Q ++   KV  LH
Sbjct: 2   DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61

Query: 163 KSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINR 222
           + +  +  ++A+  ++  A+ L  YGV+LH  +DL  +D+++G+ S+G+ VY+  +  + 
Sbjct: 62  EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121

Query: 223 FPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---R 279
           +PW  +LKIS+KR  FFI  R  + E  E  + F + +YR+ K LWK CVEHHTFF   +
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181

Query: 280 LTSTDTIPKSKFLALGSK 297
           L   +    S++  +GS+
Sbjct: 182 LLPQEKNVLSQYWTMGSR 199


>gi|161702986 ezrin [Homo sapiens]
          Length = 586

 Score =  152 bits (384), Expect = 9e-37
 Identities = 142/567 (25%), Positives = 251/567 (44%), Gaps = 57/567 (10%)

Query: 10  DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLD-----SAKEIKK 64
           D   E  ++ +  G+ L  +V + + L E  YFGL   DN    TWL      SA+E++K
Sbjct: 13  DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72

Query: 65  QVRGVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYT 123
           +    P  F F  KFYP D A+ L +DIT+    LQ+++ I++  + C   T  LLGSY 
Sbjct: 73  EN---PLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYA 129

Query: 124 IQSELGDYDPELHGVDYVSDFKLAPNQT--------KELEEKVMELHKSYRSMTPAQADL 175
           +Q++ GDY+ E+H   Y+S  +L P +          + E+++   H  +R M    A L
Sbjct: 130 VQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAML 189

Query: 176 EFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYK--DKLRIN-RFPWPKVLKIS 232
           E+L+ A+ L MYG++  + K+ +G D+ LGV + GL +Y+  DKL     FPW ++  IS
Sbjct: 190 EYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNIS 249

Query: 233 YKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKF 291
           +    F IK  P +++  +    F  P  R  K++ ++C+  H  + R    DTI   + 
Sbjct: 250 FNDKKFVIK--PIDKKAPDFV--FYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQM 305

Query: 292 LALGSKFRYSGRTQAQ----TRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSP 347
            A   + ++  + + Q     ++    ++R      R   +   R  D       A+R  
Sbjct: 306 KAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERE- 364

Query: 348 RPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVK-AEVKKEDEPPEQAEPEPTEAWK 406
                      Q+     L+   K+      + E  + A ++ ++E   QA  +     +
Sbjct: 365 --------LSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQ 416

Query: 407 VEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELK 466
           +     E T   +  ++ ++++E  D    +   +    +DL K++EE+           
Sbjct: 417 LAAELAEYTAKIALLEEARRRKE--DEVEEWQHRAKEAQDDLVKTKEEL----------- 463

Query: 467 KNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSE 526
            + + + P P P    + +S H    +L   G  PTG    L    +  I D+ N  K  
Sbjct: 464 -HLVMTAPPPPPPPVYEPVSYHVQ-ESLQDEGAEPTGYSAEL---SSEGIRDDRNEEKRI 518

Query: 527 IPTKDVPIVHTETKTITYEAAQTDDNS 553
              +    V  +  T++ E +Q  D +
Sbjct: 519 TEAEKNERVQRQLLTLSSELSQARDEN 545


>gi|21614499 ezrin [Homo sapiens]
          Length = 586

 Score =  152 bits (384), Expect = 9e-37
 Identities = 142/567 (25%), Positives = 251/567 (44%), Gaps = 57/567 (10%)

Query: 10  DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLD-----SAKEIKK 64
           D   E  ++ +  G+ L  +V + + L E  YFGL   DN    TWL      SA+E++K
Sbjct: 13  DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72

Query: 65  QVRGVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYT 123
           +    P  F F  KFYP D A+ L +DIT+    LQ+++ I++  + C   T  LLGSY 
Sbjct: 73  EN---PLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYA 129

Query: 124 IQSELGDYDPELHGVDYVSDFKLAPNQT--------KELEEKVMELHKSYRSMTPAQADL 175
           +Q++ GDY+ E+H   Y+S  +L P +          + E+++   H  +R M    A L
Sbjct: 130 VQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAML 189

Query: 176 EFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYK--DKLRIN-RFPWPKVLKIS 232
           E+L+ A+ L MYG++  + K+ +G D+ LGV + GL +Y+  DKL     FPW ++  IS
Sbjct: 190 EYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNIS 249

Query: 233 YKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKF 291
           +    F IK  P +++  +    F  P  R  K++ ++C+  H  + R    DTI   + 
Sbjct: 250 FNDKKFVIK--PIDKKAPDFV--FYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQM 305

Query: 292 LALGSKFRYSGRTQAQ----TRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSP 347
            A   + ++  + + Q     ++    ++R      R   +   R  D       A+R  
Sbjct: 306 KAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERE- 364

Query: 348 RPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVK-AEVKKEDEPPEQAEPEPTEAWK 406
                      Q+     L+   K+      + E  + A ++ ++E   QA  +     +
Sbjct: 365 --------LSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQ 416

Query: 407 VEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELK 466
           +     E T   +  ++ ++++E  D    +   +    +DL K++EE+           
Sbjct: 417 LAAELAEYTAKIALLEEARRRKE--DEVEEWQHRAKEAQDDLVKTKEEL----------- 463

Query: 467 KNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSE 526
            + + + P P P    + +S H    +L   G  PTG    L    +  I D+ N  K  
Sbjct: 464 -HLVMTAPPPPPPPVYEPVSYHVQ-ESLQDEGAEPTGYSAEL---SSEGIRDDRNEEKRI 518

Query: 527 IPTKDVPIVHTETKTITYEAAQTDDNS 553
              +    V  +  T++ E +Q  D +
Sbjct: 519 TEAEKNERVQRQLLTLSSELSQARDEN 545


>gi|4505257 moesin [Homo sapiens]
          Length = 577

 Score =  145 bits (365), Expect = 1e-34
 Identities = 120/466 (25%), Positives = 216/466 (46%), Gaps = 33/466 (7%)

Query: 10  DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQV--R 67
           D   E  ++ +  G+ L  +V + + L E  +FGL   D     TWL   K++  Q   +
Sbjct: 13  DAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRK 72

Query: 68  GVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126
             P  F F  KFYP D ++ L +DIT+    LQ+++ I+   + C   T  LL SY +QS
Sbjct: 73  ESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQS 132

Query: 127 ELGDYDPELHGVDYVSDFKLAPNQTKE--------LEEKVMELHKSYRSMTPAQADLEFL 178
           + GD++ E+H   Y++  KL P +  E         EE++   H+ +R M    A LE+L
Sbjct: 133 KYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYL 192

Query: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKR 235
           + A+ L MYGV+    K+ +G ++ LGV + GL +Y+   R+     FPW ++  IS+  
Sbjct: 193 KIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFND 252

Query: 236 SSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLAL 294
             F IK  P +++  +    F  P  R  K++  +C+  H  + R    DTI   +  A 
Sbjct: 253 KKFVIK--PIDKKAPDFV--FYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQ 308

Query: 295 GSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPT-SAP 353
             + ++      Q +   A+++      E    ++     +    ++   +    T  A 
Sbjct: 309 AREEKH------QKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKAQ 362

Query: 354 AITQGQVAEGGVLDASAKK--TVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTH 411
              + Q      L+   K+  +   K  KE  +AE  KE       + + T+    E+  
Sbjct: 363 QELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQ----EQLA 418

Query: 412 IEVTVPTSNGDQTQKKRERLDGENI-YIRHSNLMLEDLDKSQEEIK 456
           +E+   T+   Q +  R++ + E + + + + ++ EDL+K++ E+K
Sbjct: 419 LEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELK 464


>gi|4506467 radixin [Homo sapiens]
          Length = 583

 Score =  137 bits (345), Expect = 3e-32
 Identities = 118/466 (25%), Positives = 215/466 (46%), Gaps = 33/466 (7%)

Query: 10  DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQ--VR 67
           D   E  ++ +  G+ L  +V + + L E  +FGL   D+    TWL   K++ +Q   +
Sbjct: 13  DAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKK 72

Query: 68  GVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126
             P  F F  KF+P D ++ L ++IT+    LQ+++ I+   + C   T  LL SY +Q+
Sbjct: 73  ENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQA 132

Query: 127 ELGDYDPELHGVDYVSDFKLAPNQ-------TKE-LEEKVMELHKSYRSMTPAQADLEFL 178
           + GDY+ E+H   Y+++ +L P +       TKE  EE++   H+ +R M    + +E+L
Sbjct: 133 KYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYL 192

Query: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYK--DKLRIN-RFPWPKVLKISYKR 235
           + A+ L MYGV+  + K+ +G ++ LGV + GL +Y+  DKL     FPW ++  IS+  
Sbjct: 193 KIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFND 252

Query: 236 SSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLAL 294
             F IK  P +++  +    F  P  R  K++  +C+  H  + R    DTI   +  A 
Sbjct: 253 KKFVIK--PIDKKAPDFV--FYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQ 308

Query: 295 GSKFRYSGRTQ----AQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPT 350
             + ++  + +       ++   + ++     ER   +   R          A +     
Sbjct: 309 AREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQ 368

Query: 351 SAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKT 410
           +  A+   Q       +    K    + +KE   AE  K     +QA  +     ++   
Sbjct: 369 TRKALELDQ-------ERKRAKEEAERLEKERRAAEEAK-SAIAKQAADQMKNQEQLAAE 420

Query: 411 HIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIK 456
             E T   +  ++ +KK+E    E  +   +    EDL+K++EE+K
Sbjct: 421 LAEFTAKIALLEEAKKKKEEEATE--WQHKAFAAQEDLEKTKEELK 464


>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score =  126 bits (317), Expect = 5e-29
 Identities = 101/410 (24%), Positives = 181/410 (44%), Gaps = 21/410 (5%)

Query: 10  DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQ--VR 67
           D   E   E   KG+DL   VC  L L E  +FGL      T   WL   K++      +
Sbjct: 30  DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTV-AWLKMDKKVLDHDVSK 88

Query: 68  GVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126
             P  F F  KFYP +  + L ++IT++   LQ+++ I+  ++ C      LL SY +Q+
Sbjct: 89  EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148

Query: 127 ELGDYDPELHGVDYVSDFKLAPNQTKEL--------EEKVMELHKSYRSMTPAQADLEFL 178
           + GDYDP +H   +++  +L P +   L        EE++   +  +R     +A++E+L
Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208

Query: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKR 235
           + A+ L MYGV+    ++ +G +++LGV + GL +Y  + R+     FPW ++  ISY  
Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268

Query: 236 SSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLAL 294
             F IK    + + ++    F     R  K + ++C+  H  F R    D++   +  A 
Sbjct: 269 KEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324

Query: 295 GSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPA 354
             + +   + + Q       +   A        +R  +  + A   + A      T+   
Sbjct: 325 AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLL 384

Query: 355 ITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEA 404
             + Q+ E       A+K    + + + +KA   + +E     E +  EA
Sbjct: 385 AEKAQITEEEA-KLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEA 433


>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score =  126 bits (317), Expect = 5e-29
 Identities = 101/410 (24%), Positives = 181/410 (44%), Gaps = 21/410 (5%)

Query: 10  DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQ--VR 67
           D   E   E   KG+DL   VC  L L E  +FGL      T   WL   K++      +
Sbjct: 30  DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTV-AWLKMDKKVLDHDVSK 88

Query: 68  GVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126
             P  F F  KFYP +  + L ++IT++   LQ+++ I+  ++ C      LL SY +Q+
Sbjct: 89  EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148

Query: 127 ELGDYDPELHGVDYVSDFKLAPNQTKEL--------EEKVMELHKSYRSMTPAQADLEFL 178
           + GDYDP +H   +++  +L P +   L        EE++   +  +R     +A++E+L
Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208

Query: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKR 235
           + A+ L MYGV+    ++ +G +++LGV + GL +Y  + R+     FPW ++  ISY  
Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268

Query: 236 SSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLAL 294
             F IK    + + ++    F     R  K + ++C+  H  F R    D++   +  A 
Sbjct: 269 KEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324

Query: 295 GSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPA 354
             + +   + + Q       +   A        +R  +  + A   + A      T+   
Sbjct: 325 AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLL 384

Query: 355 ITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEA 404
             + Q+ E       A+K    + + + +KA   + +E     E +  EA
Sbjct: 385 AEKAQITEEEA-KLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEA 433


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,958,786
Number of Sequences: 37866
Number of extensions: 1156990
Number of successful extensions: 4934
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 4218
Number of HSP's gapped (non-prelim): 910
length of query: 641
length of database: 18,247,518
effective HSP length: 109
effective length of query: 532
effective length of database: 14,120,124
effective search space: 7511905968
effective search space used: 7511905968
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.