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Search of human proteins with 42716289
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42716289 erythrocyte membrane protein band 4.1
(elliptocytosis 1, RH-linked) isoform 1 [Homo sapiens]
(775 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 1541 0.0
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 1093 0.0
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 1017 0.0
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 570 e-162
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 512 e-145
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 512 e-145
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 496 e-140
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 486 e-137
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 484 e-136
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 257 3e-68
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 230 3e-60
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 223 7e-58
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 221 3e-57
gi|117500790 FERM domain containing 3 [Homo sapiens] 213 5e-55
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 210 4e-54
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 210 4e-54
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 210 4e-54
gi|34916000 FERM domain containing 7 [Homo sapiens] 197 4e-50
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 196 9e-50
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 195 2e-49
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 194 2e-49
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 156 6e-38
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i... 156 8e-38
gi|161702986 ezrin [Homo sapiens] 137 4e-32
gi|21614499 ezrin [Homo sapiens] 137 4e-32
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 134 4e-31
gi|4505257 moesin [Homo sapiens] 124 3e-28
gi|4506467 radixin [Homo sapiens] 123 6e-28
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 117 4e-26
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 117 4e-26
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 1541 bits (3990), Expect = 0.0
Identities = 775/775 (100%), Positives = 775/775 (100%)
Query: 1 MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDT 60
MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDT
Sbjct: 1 MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDT 60
Query: 61 PTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGT 120
PTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGT
Sbjct: 61 PTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGT 120
Query: 121 SLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECS 180
SLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECS
Sbjct: 121 SLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECS 180
Query: 181 KIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVETWLDSAKEIKKQV 240
KIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVETWLDSAKEIKKQV
Sbjct: 181 KIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVETWLDSAKEIKKQV 240
Query: 241 RGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 300
RGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS
Sbjct: 241 RGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 300
Query: 301 ELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSM 360
ELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSM
Sbjct: 301 ELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSM 360
Query: 361 YGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGE 420
YGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGE
Sbjct: 361 YGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGE 420
Query: 421 QEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQA 480
QEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQA
Sbjct: 421 QEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQA 480
Query: 481 QTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVL 540
QTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVL
Sbjct: 481 QTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVL 540
Query: 541 DASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDLDKSQEEIKKHHASISELK 600
DASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDLDKSQEEIKKHHASISELK
Sbjct: 541 DASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDLDKSQEEIKKHHASISELK 600
Query: 601 KNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSE 660
KNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSE
Sbjct: 601 KNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSE 660
Query: 661 IPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKG 720
IPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKG
Sbjct: 661 IPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKG 720
Query: 721 GISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 775
GISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE
Sbjct: 721 GISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 775
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 1093 bits (2826), Expect = 0.0
Identities = 566/641 (88%), Positives = 566/641 (88%), Gaps = 75/641 (11%)
Query: 210 MHCKVSLLDDTVYECVVE-----------------------------------TWLDSAK 234
MHCKVSLLDDTVYECVVE TWLDSAK
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 235 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 294
EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG
Sbjct: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
Query: 295 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 354
SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
Query: 355 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 414
AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
Query: 415 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 474
KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
Query: 475 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 534
SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV
Sbjct: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
Query: 535 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK-------------- 580
AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK
Sbjct: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSN 420
Query: 581 --------------------------DLDKSQEEIKKHHASISELKKNFMESVPEPRPSE 614
DLDKSQEEIKKHHASISELKKNFMESVPEPRPSE
Sbjct: 421 GDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSE 480
Query: 615 WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK 674
WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK
Sbjct: 481 WDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETK 540
Query: 675 TITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVIT 734
TITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVIT
Sbjct: 541 TITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVIT 600
Query: 735 GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 775
GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE
Sbjct: 601 GDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 641
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 1017 bits (2630), Expect = 0.0
Identities = 532/622 (85%), Positives = 532/622 (85%), Gaps = 90/622 (14%)
Query: 210 MHCKVSLLDDTVYECVVE-----------------------------------TWLDSAK 234
MHCKVSLLDDTVYECVVE TWLDSAK
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 235 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 294
EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG
Sbjct: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
Query: 295 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 354
SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
Query: 355 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 414
AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
Query: 415 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 474
KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
Query: 475 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 534
SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV
Sbjct: 301 SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
Query: 535 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK-------------- 580
AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK
Sbjct: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYIR 420
Query: 581 -------DLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQ 633
DLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQ
Sbjct: 421 HSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQ 480
Query: 634 IPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPG 693
IPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQT
Sbjct: 481 IPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQT---------- 530
Query: 694 VLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAK 753
VKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAK
Sbjct: 531 ------------------------VKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAK 566
Query: 754 EQHPDMSVTKVVVHQETEIADE 775
EQHPDMSVTKVVVHQETEIADE
Sbjct: 567 EQHPDMSVTKVVVHQETEIADE 588
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 570 bits (1469), Expect = e-162
Identities = 368/879 (41%), Positives = 495/879 (56%), Gaps = 126/879 (14%)
Query: 1 MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDT 60
MTTE V+E + Q G +A +E + + Q++ + Q A+ +
Sbjct: 1 MTTEVGSVSEVKKDSSQL---GTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQS 57
Query: 61 PTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQ---VSEEEGKEVES----------DKE 107
K ++ TSESRG+SR +LK+ KS V+++ G + E DKE
Sbjct: 58 SLRRQ--KREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKE 115
Query: 108 KG---EGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQ----- 159
+ E Q + + ++ +K + +P + + + S+S E QP +
Sbjct: 116 EPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKE---EKPSVSKVEMQPTELVSKE 172
Query: 160 --EELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLL 217
E+++E + +++ G E +++ E KAE KASQK +K + + CKV+LL
Sbjct: 173 REEKVKETQEDKLEGGAAKRETKEVQTNE----LKAE---KASQKVTKKTKTVQCKVTLL 225
Query: 218 DDTVYECVVE-----------------------------------TWLDSAKEIKKQVRG 242
D T Y C +E WLD AKEIK+Q+R
Sbjct: 226 DGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRN 285
Query: 243 VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSEL 302
+PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLGSYT+Q+EL
Sbjct: 286 LPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAEL 345
Query: 303 GDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYG 362
GDYDPE HG +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLENAK+LSMYG
Sbjct: 346 GDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYG 405
Query: 363 VDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQE 422
VDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+IK+RP E E
Sbjct: 406 VDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELE 465
Query: 423 QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQT 482
Q+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S + PK+KFL LGSKFRYSGRTQAQT
Sbjct: 466 QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQT 525
Query: 483 RQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT---QGQVAEG 537
RQAS LIDRPAPHFERT+SKR SRSLDGA +D + P +A I+ G V+
Sbjct: 526 RQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIA 585
Query: 538 GVLDASAKKTV-VPKAQKETVKAEVKKED---EPPEQAEPEPTEAWKDLDKSQEEIKKHH 593
V D ++ V P E KK E ++LDK+QE+I KH
Sbjct: 586 VVQDGDGRREVRSPTKAPHLQLIEGKKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQ 645
Query: 594 ASISELKKNFMESVPEPRPSEWDKRLST-------HSPFRTLNI---------------- 630
ASISELK+NFMES PEPRP+EW+KR T S TLNI
Sbjct: 646 ASISELKRNFMESTPEPRPNEWEKRRITPLSLQTQGSSHETLNIVEEKKRAEVGKDERVI 705
Query: 631 ----NG-QIPTGEGP-------PLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITY 678
NG +I G GP P+ + + ++S +++ SE +DV +
Sbjct: 706 TEEMNGKEISPGSGPGEIRKVEPVTQKDSTSLSSESSSSSSESEEEDVGEYRPHHRVTEG 765
Query: 679 EAAQTDDNSGDLDPGVLLTAQTITSE--TPSSTTTTQITKTVKGGISETRIEKRI---VI 733
+ + +++ A+ + E P ++ TQ +V ET I++ + I
Sbjct: 766 TIREEQEYEEEVEEEPRPAAKVVEREEAVPEASPVTQAGASVI--TVETVIQENVGAQKI 823
Query: 734 TGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEI 772
G+ + H+ L Q + E E+ P V V H + ++
Sbjct: 824 PGEKSV-HEGALKQDMGEEAEEEP-QKVNGEVSHVDIDV 860
Score = 193 bits (491), Expect = 4e-49
Identities = 115/239 (48%), Positives = 153/239 (64%), Gaps = 27/239 (11%)
Query: 561 VKKEDEPPEQAEPEPTEAWKDLDKSQ-----EEIKKHHASISELKKNFMESVPEPR---- 611
+++E E E+ E EP A K +++ + + + AS+ ++ E+V +
Sbjct: 767 IREEQEYEEEVEEEPRPAAKVVEREEAVPEASPVTQAGASVITVETVIQENVGAQKIPGE 826
Query: 612 ---------------PSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANA 656
E ++++ +++ QI PP+VKT+ VTISD +
Sbjct: 827 KSVHEGALKQDMGEEAEEEPQKVNGEVSHVDIDVLPQIICCSEPPVVKTEMVTISDASQ- 885
Query: 657 VKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITK 716
++EI TK+VPIV TETKTITYE+ Q D +G D G LLTAQTITSE+ S+TTTT ITK
Sbjct: 886 -RTEISTKEVPIVQTETKTITYESPQIDGGAGG-DSGTLLTAQTITSESVSTTTTTHITK 943
Query: 717 TVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 775
TVKGGISETRIEKRIVITGD DIDHDQ L QAI+EA+EQHPDMSVT+VVVH+ETE+A+E
Sbjct: 944 TVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 1002
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 512 bits (1319), Expect = e-145
Identities = 296/611 (48%), Positives = 384/611 (62%), Gaps = 78/611 (12%)
Query: 1 MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDT 60
MTTE V+E + Q G +A +E + + Q++ + Q A+ +
Sbjct: 1 MTTEVGSVSEVKKDSSQL---GTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQS 57
Query: 61 PTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQ---VSEEEGKEVES----------DKE 107
K ++ TSESRG+SR +LK+ KS V+++ G + E DKE
Sbjct: 58 SLRRQ--KREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKE 115
Query: 108 KG---EGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQ----- 159
+ E Q + + ++ +K + +P + + + S+S E QP +
Sbjct: 116 EPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKE---EKPSVSKVEMQPTELVSKE 172
Query: 160 --EELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLL 217
E+++E + +++ G E +++ E KAE KASQK +K + + CKV+LL
Sbjct: 173 REEKVKETQEDKLEGGAAKRETKEVQTNE----LKAE---KASQKVTKKTKTVQCKVTLL 225
Query: 218 DDTVYECVVE-----------------------------------TWLDSAKEIKKQVRG 242
D T Y C +E WLD AKEIK+Q+R
Sbjct: 226 DGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRN 285
Query: 243 VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSEL 302
+PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLGSYT+Q+EL
Sbjct: 286 LPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAEL 345
Query: 303 GDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYG 362
GDYDPE HG +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLENAK+LSMYG
Sbjct: 346 GDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYG 405
Query: 363 VDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQE 422
VDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+IK+RP E E
Sbjct: 406 VDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELE 465
Query: 423 QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQT 482
Q+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S + PK+KFL LGSKFRYSGRTQAQT
Sbjct: 466 QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQT 525
Query: 483 RQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT---QGQVAEG 537
RQAS LIDRPAPHFERT+SKR SRSLDGA +D + P +A I+ G V+
Sbjct: 526 RQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIA 585
Query: 538 GVLDASAKKTV 548
V D ++ V
Sbjct: 586 VVQDGDGRREV 596
Score = 107 bits (267), Expect = 4e-23
Identities = 51/60 (85%), Positives = 57/60 (95%)
Query: 716 KTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 775
KTVKGGISETRIEKRIVITGD DIDHDQ L QAI+EA+EQHPDMSVT+VVVH+ETE+A+E
Sbjct: 611 KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 670
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 512 bits (1319), Expect = e-145
Identities = 296/611 (48%), Positives = 384/611 (62%), Gaps = 78/611 (12%)
Query: 1 MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDT 60
MTTE V+E + Q G +A +E + + Q++ + Q A+ +
Sbjct: 1 MTTEVGSVSEVKKDSSQL---GTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQS 57
Query: 61 PTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQ---VSEEEGKEVES----------DKE 107
K ++ TSESRG+SR +LK+ KS V+++ G + E DKE
Sbjct: 58 SLRRQ--KREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKE 115
Query: 108 KG---EGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQ----- 159
+ E Q + + ++ +K + +P + + + S+S E QP +
Sbjct: 116 EPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKE---EKPSVSKVEMQPTELVSKE 172
Query: 160 --EELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLL 217
E+++E + +++ G E +++ E KAE KASQK +K + + CKV+LL
Sbjct: 173 REEKVKETQEDKLEGGAAKRETKEVQTNE----LKAE---KASQKVTKKTKTVQCKVTLL 225
Query: 218 DDTVYECVVE-----------------------------------TWLDSAKEIKKQVRG 242
D T Y C +E WLD AKEIK+Q+R
Sbjct: 226 DGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRN 285
Query: 243 VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSEL 302
+PW FTFNVKFYPPDP+QLTEDITRY+LCLQLRQDI +GRLPCSF T ALLGSYT+Q+EL
Sbjct: 286 LPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAEL 345
Query: 303 GDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYG 362
GDYDPE HG +S+F+ AP QTKELEEKV ELHK++R ++PAQAD +FLENAK+LSMYG
Sbjct: 346 GDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYG 405
Query: 363 VDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQE 422
VDLH AKD EGVDI LGVC++GLL+YKD+LRINRF WPK+LKISYKRS+F+IK+RP E E
Sbjct: 406 VDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELE 465
Query: 423 QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQT 482
Q+ESTIGFKLP++RAAK+LWKVCVEHHTF+RL S + PK+KFL LGSKFRYSGRTQAQT
Sbjct: 466 QFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQT 525
Query: 483 RQASALIDRPAPHFERTASKRASRSLDGA--AAVDSADRSPRPTSAPAIT---QGQVAEG 537
RQAS LIDRPAPHFERT+SKR SRSLDGA +D + P +A I+ G V+
Sbjct: 526 RQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIA 585
Query: 538 GVLDASAKKTV 548
V D ++ V
Sbjct: 586 VVQDGDGRREV 596
Score = 107 bits (267), Expect = 4e-23
Identities = 51/60 (85%), Positives = 57/60 (95%)
Query: 716 KTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 775
KTVKGGISETRIEKRIVITGD DIDHDQ L QAI+EA+EQHPDMSVT+VVVH+ETE+A+E
Sbjct: 611 KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 670
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 496 bits (1277), Expect = e-140
Identities = 277/532 (52%), Positives = 350/532 (65%), Gaps = 71/532 (13%)
Query: 151 SSAETQPAQEEL-REDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRN 209
S +T+PA++ L E+ D+ E +GL E + SKA+ K+ QK +K+++
Sbjct: 50 SQQDTRPAEQSLDMEEKDYS--EADGLSE--------RTTPSKAQ---KSPQKIAKKYKS 96
Query: 210 MHCKVSLLDDTVYECVVE-----------------------------------TWLDSAK 234
C+V+LLD + YEC VE WLD +K
Sbjct: 97 AICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSK 156
Query: 235 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 294
EIKKQ+R PWNF F VKFYPPDPAQLTEDITRYYLCLQLR DI+ GRLPCSF T ALLG
Sbjct: 157 EIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLG 216
Query: 295 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 354
SY +Q+ELGDYD E H +YVS+ + APNQT+ELEE++MELHK+YR MTP +A++ FLEN
Sbjct: 217 SYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLEN 276
Query: 355 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 414
AKKLSMYGVDLH AKD EG+DI+LGVC++GLL+Y+D+LRINRF WPK+LKISYKRS+F+I
Sbjct: 277 AKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYI 336
Query: 415 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 474
KIRPGE EQ+ESTIGFKLP++R+AK+LWKVC+EHHTFFRL S + PK FL +GSKFRY
Sbjct: 337 KIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSKFRY 395
Query: 475 SGRTQAQTRQASALIDRPAPHFERTASKR--ASRSLDGAAAVDSADRSPRPTSAPAITQG 532
SGRTQAQTRQASALIDRPAP FER++SKR SRSLDGA A S + P
Sbjct: 396 SGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGP----- 450
Query: 533 QVAEGGVLDASAKK-TVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDLDKSQEEIKK 591
+G D + +A++ V+ K ++ PEQ E P + LDK ++ + K
Sbjct: 451 ---DGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQ-ETTPRHKQEFLDKPEDVLLK 506
Query: 592 HHASISELKKNFME--SVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPP 641
H ASI+ELK+ E S R +W++ R L + P+ +G P
Sbjct: 507 HQASINELKRTLKEPNSKLIHRDRDWERE-------RRLPSSPASPSPKGTP 551
Score = 107 bits (266), Expect = 5e-23
Identities = 77/196 (39%), Positives = 105/196 (53%), Gaps = 23/196 (11%)
Query: 587 EEIKKHHASISEL---KKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEG---- 639
E +K ++S L KK E+V + R S D T ++G G
Sbjct: 693 EPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDN---------TQQVDGSASVGREFIAT 743
Query: 640 PPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQ 699
P + T+T++ + N++KS K + +T+ E G VL +
Sbjct: 744 TPSITTETISTTME-NSLKSG---KGAAAMIPGPQTVATEIRSLSPIIGK---DVLTSTY 796
Query: 700 TITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDM 759
T+ET S++TTT +TKTVKGG SETRIEKRI+ITGD D+D DQ L AIKEAK QHPDM
Sbjct: 797 GATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDM 856
Query: 760 SVTKVVVHQETEIADE 775
VTK VV++ET+ + E
Sbjct: 857 LVTKAVVYRETDPSPE 872
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 486 bits (1250), Expect = e-137
Identities = 282/566 (49%), Positives = 363/566 (64%), Gaps = 66/566 (11%)
Query: 130 APIAAPEPELKTDPSLDLHSLSSAETQPAQEELRE-DPDFEIKEGEGLEECSKIEVKEES 188
AP+ P P+ + +L+ + ++A + P + E+ + + +F + + LE ++E + S
Sbjct: 31 APVPEP-PKEEQQQALEQFAAAAAHSTPVRREVTDKEQEFAARAAKQLEY-QQLEDDKLS 88
Query: 189 PQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVE--------------------- 227
+S + ++ K ++K ++M CKV LLD + Y C VE
Sbjct: 89 QKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEK 148
Query: 228 --------------TWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQ 273
WLD AKEIKKQVR W+F+FNVKFYPPDPAQL+EDITRYYLCLQ
Sbjct: 149 DYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQ 208
Query: 274 LRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVM 333
LR DIV+GRLPCSF TLALLGSYT+QSELGDYDP+ G DY+S+F+ APN TKELE+KV+
Sbjct: 209 LRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVI 268
Query: 334 ELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLR 393
ELHKS+R MTPA+A++ FLENAKKLSMYGVDLH AKD EGV+I+LGVC+SGLL+Y+D+LR
Sbjct: 269 ELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLR 328
Query: 394 INRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFR 453
INRF WPKVLKISYKR++F+IKIRPGE EQ+ESTIGFKLP++RAAK+LWKVCVEHHTFFR
Sbjct: 329 INRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFR 388
Query: 454 LTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKR--ASRSLDGA 511
L + PK KFL LGSKFRYSGRTQAQTR+ASALIDRPAP+FER++SKR SRSLDG
Sbjct: 389 LLLPEAPPK-KFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGE 447
Query: 512 AAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQA 571
T A T+ G+ + TV P+ + E + E +ED+ +
Sbjct: 448 VG----------TGQYATTK------GISQTNLITTVTPEKKAEEERDE--EEDKRRKGE 489
Query: 572 EPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVP---EPRPSEWDKRLSTHSPFRTL 628
E P A + KS + +S + + P R E D +L + P R
Sbjct: 490 EVTPISAIRHEGKS-PGLGTDSCPLSPPSTHCAPTSPTELRRRCKENDCKLPGYEPSRAE 548
Query: 629 NINGQ---IPTGEGPPLVKTQTVTIS 651
++ G+ G G P + Q V S
Sbjct: 549 HLPGEPALDSDGPGRPYLGDQDVAFS 574
Score = 195 bits (495), Expect = 2e-49
Identities = 102/134 (76%), Positives = 116/134 (86%), Gaps = 2/134 (1%)
Query: 643 VKTQTVTI-SDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTI 701
VKT+T++ S + VK EI TK+VP+VHTETKTITYE++Q D + DL+PGVL++AQTI
Sbjct: 951 VKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGT-DLEPGVLMSAQTI 1009
Query: 702 TSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSV 761
TSET S+TTTT ITKTVKGGISETRIEKRIVITGDADIDHDQ L QAIKEAKEQHPDMSV
Sbjct: 1010 TSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSV 1069
Query: 762 TKVVVHQETEIADE 775
TKVVVH+ETEI E
Sbjct: 1070 TKVVVHKETEITPE 1083
Score = 50.1 bits (118), Expect = 8e-06
Identities = 43/142 (30%), Positives = 67/142 (47%), Gaps = 13/142 (9%)
Query: 521 PRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK 580
P+ S A ++ + +++T A ET E +E++ +A+
Sbjct: 669 PKAASLSASLDNDPSDSSEEETDSERTDTA-ADGETTATESDQEEDAELKAQ-------- 719
Query: 581 DLDKSQEEIKKHHASISELKKNFME-SVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEG 639
+L+K+Q+++ KH +ISELK+ F+E S +EW+KRLST SP R P E
Sbjct: 720 ELEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLST-SPVRLAARQEDAPMIE- 777
Query: 640 PPLVKTQTVTISDNANAVKSEI 661
PLV +T S SEI
Sbjct: 778 -PLVPEETKQSSGEKLMDGSEI 798
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 484 bits (1247), Expect = e-136
Identities = 264/497 (53%), Positives = 327/497 (65%), Gaps = 70/497 (14%)
Query: 184 VKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVE---------------- 227
+ E + SKA+ K+ QK +K+++ C+V+LLD + YEC VE
Sbjct: 12 LSERTTPSKAQ---KSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHL 68
Query: 228 -------------------TWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRY 268
WLD +KEIKKQ+R PWNF F VKFYPPDPAQLTEDITRY
Sbjct: 69 NLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRY 128
Query: 269 YLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKEL 328
YLCLQLR DI+ GRLPCSF T ALLGSY +Q+ELGDYD E H +YVS+ + APNQT+EL
Sbjct: 129 YLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL 188
Query: 329 EEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVY 388
EE++MELHK+YR MTP +A++ FLENAKKLSMYGVDLH AKD EG+DI+LGVC++GLL+Y
Sbjct: 189 EERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIY 248
Query: 389 KDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEH 448
+D+LRINRF WPK+LKISYKRS+F+IKIRPGE EQ+ESTIGFKLP++R+AK+LWKVC+EH
Sbjct: 249 RDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEH 308
Query: 449 HTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKR--ASR 506
HTFFRL S + PK FL +GSKFRYSGRTQAQTRQASALIDRPAP FER++SKR SR
Sbjct: 309 HTFFRLVSPEPPPKG-FLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSR 367
Query: 507 SLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE 566
SLDGA A S + P +G K ++ + E E
Sbjct: 368 SLDGAEFSRPASVSENHDAGP--------DG------------DKRDEDGESGGQRSEAE 407
Query: 567 PPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFME--SVPEPRPSEWDKRLSTHSP 624
E P + K LDK ++ + KH ASI+ELK+ E S R +W++
Sbjct: 408 EGEVRTPTKIKELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERE------ 461
Query: 625 FRTLNINGQIPTGEGPP 641
R L + P+ +G P
Sbjct: 462 -RRLPSSPASPSPKGTP 477
Score = 108 bits (269), Expect = 2e-23
Identities = 79/218 (36%), Positives = 114/218 (52%), Gaps = 25/218 (11%)
Query: 578 AWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTH-SPFRTLNINGQIPT 636
A++D +S E+ + + F + + PS+ D+ SP R +P
Sbjct: 558 AFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQ 617
Query: 637 GEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYE-AAQTDDNSGDLDPG-- 693
E VKT+T+T+S + A++ +I + V T E + ++ + + PG
Sbjct: 618 FEP---VKTETMTVS--SLAIRKKIEPEAVLQTRVSAMDNTQENSLKSGKGAAAMIPGPQ 672
Query: 694 ----------------VLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDA 737
VL + T+ET S++TTT +TKTVKGG SETRIEKRI+ITGD
Sbjct: 673 TVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDE 732
Query: 738 DIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 775
D+D DQ L AIKEAK QHPDM VTK VV++ET+ + E
Sbjct: 733 DVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPE 770
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 257 bits (657), Expect = 3e-68
Identities = 129/285 (45%), Positives = 184/285 (64%), Gaps = 6/285 (2%)
Query: 229 WLDSAKEIKKQV-RGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSF 287
WLD K I+KQ+ RG P++ F VKF+ DP +L E+ TRY LQ++QDI+ GRLPC
Sbjct: 84 WLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPS 143
Query: 288 ATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQA 347
T ALL S+ +QSELGDYD + Y+SD+ PNQ ++ E+++ +LH+ + ++PA+A
Sbjct: 144 NTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEA 203
Query: 348 DLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISY 407
+ +L A+ L +YGV+ H A+D +I++GV S G+L+YK+++R+N FPW K++KIS+
Sbjct: 204 EFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISF 263
Query: 408 KRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLA 467
K FFI++R E E+ +GF + +YRA K LWK CVEHHTFFRL P+ F A
Sbjct: 264 KCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRL-DRPLPPQKNFFA 322
Query: 468 ----LGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSL 508
LGSKFRY GRT+ Q+ Q F R+ SK +R L
Sbjct: 323 HYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKL 367
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 230 bits (587), Expect = 3e-60
Identities = 123/286 (43%), Positives = 173/286 (60%), Gaps = 7/286 (2%)
Query: 226 VETWLDSAKEIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLP 284
V WLD K IKKQV+ G P+ VKFY +P L E++TRY LQL+QDI++G+L
Sbjct: 94 VAHWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLD 153
Query: 285 CSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTP 344
C F T L +Y +Q+ELGDYD H + VS+F+ P QT+E+E + E K YR TP
Sbjct: 154 CPFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTP 213
Query: 345 AQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLK 404
AQA+ +L AK L MYGVD+H K +G D LG+ +G+LV++ +I F WPK+ +
Sbjct: 214 AQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITR 273
Query: 405 ISYKRSSFFIKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTI 460
+ +K++ + + + + + E T F+L +A K LWK VEHH FFRL +
Sbjct: 274 LDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSS 333
Query: 461 PKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASR 506
+S F+ LGS+FRYSG+T+ QT + + R + FER SKR SR
Sbjct: 334 HRSGFIRLGSRFRYSGKTEYQTTKTNKA--RRSTSFERRPSKRYSR 377
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 223 bits (567), Expect = 7e-58
Identities = 138/375 (36%), Positives = 201/375 (53%), Gaps = 11/375 (2%)
Query: 226 VETWLDSAKEIKKQVRGVPWNFT-FNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLP 284
+ WLD K I KQ+R F VKF+PPD QL E++TRY LQ++QD+ GRL
Sbjct: 91 ITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLT 150
Query: 285 CSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTP 344
C+ + ALL S+ +QSE+GD+D L ++++ K P Q LE+K++E H ++ TP
Sbjct: 151 CNDTSAALLISHIVQSEIGDFDEALDR-EHLAKNKYIPQQDA-LEDKIVEFHHNHIGQTP 208
Query: 345 AQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLK 404
A++D + LE A++L MYG+ LH AKD EG I L V ++G+LV++ +IN F W KV K
Sbjct: 209 AESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRK 268
Query: 405 ISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRL-TSTDTIPKS 463
+S+KR F IK+RP Y+ T+ F + S K WK+CVEHH FFRL PK
Sbjct: 269 LSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKP 328
Query: 464 KFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASK-RASRSLDGAAAVDSADRSPR 522
+ GS FR+SGRTQ Q FER SK + RSL +++ +
Sbjct: 329 VLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQ 388
Query: 523 PTSAPAITQGQVAE--GGVLDASAKKTVV----PKAQKETVKAEVKKEDEPPEQAEPEPT 576
+ ++T G+ AE GG K+ V P + ++ + A PT
Sbjct: 389 SQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAPT 448
Query: 577 EAWKDLDKSQEEIKK 591
E +++ K + + K
Sbjct: 449 EEEEEVVKDRTQQSK 463
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 221 bits (562), Expect = 3e-57
Identities = 131/351 (37%), Positives = 191/351 (54%), Gaps = 23/351 (6%)
Query: 229 WLDSAKEIKKQVR----GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLP 284
WLD AK + + G P+ F +KFY DP +L E+ITRY LQ++QD++ GRLP
Sbjct: 70 WLDPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLP 129
Query: 285 CSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTP 344
C T A LG+Y IQSELGDYDP H YVS+++ P+Q +ELEE + +HK+ P
Sbjct: 130 CPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIP 189
Query: 345 AQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLK 404
++A+L +L AK L MYGVDLH + LG+ G++VYK+K ++ ++ WP++ K
Sbjct: 190 SEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITK 249
Query: 405 ISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD----TI 460
+ +K + F ++R ++ E++ F+ S A K LWK VEHHTFFR+ + +
Sbjct: 250 VHFKETQF--ELRVLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSLSR 307
Query: 461 PKSKFLALGSKFRYSGRTQAQ-TRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADR 519
SKF ++ K RYSGRT Q +R S + RP + R+ SK + + +S
Sbjct: 308 KLSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYPKRIAQTQPAES--- 364
Query: 520 SPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQ 570
S IT E G + + K + P K KA K E+ P Q
Sbjct: 365 ----NSISRITANM--ENGENEGTI-KIIAPSPVKSFKKA--KNENSPDTQ 406
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 213 bits (542), Expect = 5e-55
Identities = 129/382 (33%), Positives = 204/382 (53%), Gaps = 27/382 (7%)
Query: 229 WLDSAKEIKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSF 287
WL+ K I KQ++ P+ F VKFYP +P ++ E++TRY L LQ+++DI GRL CSF
Sbjct: 86 WLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSF 145
Query: 288 ATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKS-YRSMTPAQ 346
+ A LG+ +Q+ELGDYDP+ H +Y+S+F++ P Q+++LE K++E+HK+ R +P
Sbjct: 146 SDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPV 205
Query: 347 ADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKIS 406
A+ L A L YGVD H KD G LG ++G +V++ RI+ WP V K+
Sbjct: 206 AEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLK 265
Query: 407 YKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD---TIPKS 463
++ +F++ G Q++ ++ + F + A K LWK VE+ F++ + T+ S
Sbjct: 266 FEGKTFYV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSS 322
Query: 464 KFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERT--ASKRASRSLDGAAAVDSADRSP 521
K GS+FRYSG+ + +AS+ I R P R R+S SL+ ++ P
Sbjct: 323 KIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQP 382
Query: 522 RPTSAPAITQGQVAEG-GVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK 580
S P+ + ++ G GV + P VKA + ED P E+
Sbjct: 383 LLPS-PSEQEEELPLGEGVPLPKEENISAPLISSSPVKAAREYEDPPSEE---------- 431
Query: 581 DLDKSQEEIKKHHASISELKKN 602
+++IK+ +ISEL N
Sbjct: 432 -----EDKIKEEPLTISELVYN 448
>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
1 [Homo sapiens]
Length = 518
Score = 210 bits (535), Expect = 4e-54
Identities = 114/283 (40%), Positives = 166/283 (58%), Gaps = 7/283 (2%)
Query: 226 VETWLDSAKEIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLP 284
V WLD AK IKKQ++ G + F VK+Y +P L E+ TRY LQLR DI++G+L
Sbjct: 136 VAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLK 195
Query: 285 CSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTP 344
C + T L + +Q+ELG+ + H + VS+F+ PNQT+ +E + + K R +P
Sbjct: 196 CPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSP 255
Query: 345 AQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLK 404
AQA+L +L AK L MYGVD+H + +G + LG+ +G+L+++ +I F WPK+ K
Sbjct: 256 AQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITK 315
Query: 405 ISYKRSSFFIKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTI 460
+ +K+S + + + + + E T F+L S R K LWK VEHH FFRL +
Sbjct: 316 MDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKS 375
Query: 461 PKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 503
+S F+ LGS+FR+SGRT+ Q S L R FER SKR
Sbjct: 376 NRSDFIRLGSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
2 [Homo sapiens]
Length = 900
Score = 210 bits (535), Expect = 4e-54
Identities = 114/283 (40%), Positives = 166/283 (58%), Gaps = 7/283 (2%)
Query: 226 VETWLDSAKEIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLP 284
V WLD AK IKKQ++ G + F VK+Y +P L E+ TRY LQLR DI++G+L
Sbjct: 136 VAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLK 195
Query: 285 CSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTP 344
C + T L + +Q+ELG+ + H + VS+F+ PNQT+ +E + + K R +P
Sbjct: 196 CPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSP 255
Query: 345 AQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLK 404
AQA+L +L AK L MYGVD+H + +G + LG+ +G+L+++ +I F WPK+ K
Sbjct: 256 AQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITK 315
Query: 405 ISYKRSSFFIKIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTS--TDTI 460
+ +K+S + + + + + E T F+L S R K LWK VEHH FFRL +
Sbjct: 316 MDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKS 375
Query: 461 PKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKR 503
+S F+ LGS+FR+SGRT+ Q S L R FER SKR
Sbjct: 376 NRSDFIRLGSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKR 416
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 210 bits (535), Expect = 4e-54
Identities = 117/257 (45%), Positives = 156/257 (60%), Gaps = 8/257 (3%)
Query: 229 WLDSAKEIKKQVRGVPWNFTFN--VKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCS 286
WL+ K I +Q+R P N VKF+PPDP QL E+ TRY LQL++D++ RL C+
Sbjct: 98 WLEPMKPIIRQIRR-PKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCA 156
Query: 287 FATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQ 346
T ALL S+ +QSE+GDYD L +++ + P Q LE K++E H+ + TPA+
Sbjct: 157 DTTAALLTSHLLQSEIGDYDETLDR-EHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAE 214
Query: 347 ADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKIS 406
+D + LE A+KL MYG+ H A D EG I L V G+LV++ +IN F W KV K+S
Sbjct: 215 SDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLS 274
Query: 407 YKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSK-- 464
+KR F IK+ P Y+ T+ F L S K WK+CVE+HTFFRL PK+K
Sbjct: 275 FKRKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPK-PKAKAV 333
Query: 465 FLALGSKFRYSGRTQAQ 481
F + GS FRYSGRTQ Q
Sbjct: 334 FFSRGSSFRYSGRTQKQ 350
>gi|34916000 FERM domain containing 7 [Homo sapiens]
Length = 714
Score = 197 bits (500), Expect = 4e-50
Identities = 119/308 (38%), Positives = 168/308 (54%), Gaps = 10/308 (3%)
Query: 176 LEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVETWLDSAKE 235
L++ KI V ++ KA L S H N+ K + WL+ K
Sbjct: 9 LDDSQKIFVVDQKSSGKALFNLSCS------HLNLAEKEYFGLEFCSHSGNNVWLELLKP 62
Query: 236 IKKQVRGVPWN-FTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 294
I KQV+ F F VKF+P DP L E++TRY LQ+++D+ GRLPCS AL+
Sbjct: 63 ITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMV 122
Query: 295 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 354
S+ +QSELGD+ E +++ + PNQ LE K+M H+ + +PA++D+ L+
Sbjct: 123 SHILQSELGDFHEETDR-KHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDI 180
Query: 355 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 414
A+KL MYG+ H A D EG+ I L V G+LV + +IN F W K+ K+S+KR F I
Sbjct: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240
Query: 415 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLT-STDTIPKSKFLALGSKFR 473
K+ + T+ F + S A K WK CVE+H FFRL+ + PK+ + GS FR
Sbjct: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300
Query: 474 YSGRTQAQ 481
YSGRTQ Q
Sbjct: 301 YSGRTQRQ 308
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 196 bits (497), Expect = 9e-50
Identities = 117/367 (31%), Positives = 181/367 (49%), Gaps = 44/367 (11%)
Query: 208 RNMHCKVSLLDDTVYECVVET-----------------------------------WLDS 232
R C V LLDD+ Y C ++ WL+
Sbjct: 15 REYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEF 74
Query: 233 AKEIKKQVRGVP-WNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLA 291
K + KQ+R P + F VKFYP DPA L E+ITRY + LQ+++D+ GRL C + A
Sbjct: 75 TKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAA 134
Query: 292 LLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRS-MTPAQADLE 350
LL +Y +Q+E+GDYD H Y S F+ P +++LE K+ E+HK+ S TPA ++L
Sbjct: 135 LLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELN 194
Query: 351 FLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRS 410
FL A+ L YGVD H KD+ G L G +V + R++ W +V K+ ++
Sbjct: 195 FLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGK 254
Query: 411 SFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD---TIPKSKFLA 467
+F++ + ++E+ + + + P+ A K LWK +E+ F++L + T+ S
Sbjct: 255 TFYLYV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFF 312
Query: 468 LGSKFRYSGRTQAQTRQASALIDRPAPHFERT--ASKRASRSLDGAAAVDSADRSPRPTS 525
GS+FRYSGR + ++SA I R P R R+ S+ + S R+ R
Sbjct: 313 KGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAV 372
Query: 526 APAITQG 532
+I +G
Sbjct: 373 HISIMEG 379
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 195 bits (495), Expect = 2e-49
Identities = 103/300 (34%), Positives = 169/300 (56%), Gaps = 6/300 (2%)
Query: 229 WLDSAKEIKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSF 287
WL+++K I+KQ++G P F V+F+ PDP L ++ TR+ LQL+ DI GRL C
Sbjct: 84 WLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPL 143
Query: 288 ATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQA 347
+ +L SY +QS GDY+ +H Y+SD P+Q ++ KV LH+ + + ++A
Sbjct: 144 NSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEA 203
Query: 348 DLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISY 407
+ ++ A+ L YGV+LH +DL +D+++G+ S+G+ VY+ + + +PW +LKIS+
Sbjct: 204 ESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISF 263
Query: 408 KRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---RLTSTDTIPKSK 464
KR FFI R + E E + F + +YR+ K LWK CVEHHTFF +L + S+
Sbjct: 264 KRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQ 323
Query: 465 FLALGSK-FRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSAD-RSPR 522
+ +GS+ + S Q + ++ PA + ++SL + + + RSPR
Sbjct: 324 YWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPR 383
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 194 bits (494), Expect = 2e-49
Identities = 93/247 (37%), Positives = 149/247 (60%), Gaps = 4/247 (1%)
Query: 229 WLDSAKEIKKQVRG-VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSF 287
WL+++K I+KQ++G P F V+F+ PDP L ++ TR+ LQL+ DI GRL C
Sbjct: 84 WLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPL 143
Query: 288 ATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQA 347
+ +L SY +QS GDY+ +H Y+SD P+Q ++ KV LH+ + + ++A
Sbjct: 144 NSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEA 203
Query: 348 DLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISY 407
+ ++ A+ L YGV+LH +DL +D+++G+ S+G+ VY+ + + +PW +LKIS+
Sbjct: 204 ESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISF 263
Query: 408 KRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---RLTSTDTIPKSK 464
KR FFI R + E E + F + +YR+ K LWK CVEHHTFF +L + S+
Sbjct: 264 KRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQ 323
Query: 465 FLALGSK 471
+ +GS+
Sbjct: 324 YWTMGSR 330
>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
isoform 3 [Homo sapiens]
Length = 782
Score = 156 bits (395), Expect = 6e-38
Identities = 83/251 (33%), Positives = 137/251 (54%), Gaps = 5/251 (1%)
Query: 277 DIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELH 336
DI GRL C + +L SY +QS GDY+ +H Y+SD P+Q ++ KV LH
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 337 KSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINR 396
+ + + ++A+ ++ A+ L YGV+LH +DL +D+++G+ S+G+ VY+ + +
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 397 FPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---R 453
+PW +LKIS+KR FFI R + E E + F + +YR+ K LWK CVEHHTFF +
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
Query: 454 LTSTDTIPKSKFLALGSK-FRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAA 512
L + S++ +GS+ + S Q + ++ PA + ++SL +
Sbjct: 182 LLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRS 241
Query: 513 AVDSAD-RSPR 522
+ + RSPR
Sbjct: 242 PPITPNWRSPR 252
>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
Length = 737
Score = 156 bits (394), Expect = 8e-38
Identities = 73/198 (36%), Positives = 117/198 (59%), Gaps = 3/198 (1%)
Query: 277 DIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELH 336
DI GRL C + +L SY +QS GDY+ +H Y+SD P+Q ++ KV LH
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 337 KSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINR 396
+ + + ++A+ ++ A+ L YGV+LH +DL +D+++G+ S+G+ VY+ + +
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 397 FPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFF---R 453
+PW +LKIS+KR FFI R + E E + F + +YR+ K LWK CVEHHTFF +
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
Query: 454 LTSTDTIPKSKFLALGSK 471
L + S++ +GS+
Sbjct: 182 LLPQEKNVLSQYWTMGSR 199
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 137 bits (345), Expect = 4e-32
Identities = 135/515 (26%), Positives = 229/515 (44%), Gaps = 81/515 (15%)
Query: 228 TWLD-----SAKEIKKQVRGVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAG 281
TWL SA+E++K+ P F F KFYP D A+ L +DIT+ LQ+++ I++
Sbjct: 57 TWLKLDKKVSAQEVRKEN---PLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSD 113
Query: 282 RLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQT--------KELEEKVM 333
+ C T LLGSY +Q++ GDY+ E+H Y+S +L P + + E+++
Sbjct: 114 EIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQ 173
Query: 334 ELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYK--DK 391
H +R M A LE+L+ A+ L MYG++ + K+ +G D+ LGV + GL +Y+ DK
Sbjct: 174 VWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDK 233
Query: 392 LRIN-RFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHH 449
L FPW ++ IS+ F IK P +++ + F P R K++ ++C+ H
Sbjct: 234 LTPKIGFPWSEIRNISFNDKKFVIK--PIDKKAPDFV--FYAPRLRINKRILQLCMGNHE 289
Query: 450 TFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQ-------------------TRQASALID 490
+ R DTI + A + ++ + + Q R+ L+
Sbjct: 290 LYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELML 349
Query: 491 RPAPHFERTASKRASRSL------------DGAAAVDSADRSPRPTSAPAITQGQVAEGG 538
R + E+T K+A R L + A + A+R A + ++
Sbjct: 350 RLQDYEEKT--KKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQA 407
Query: 539 VLDASAKKTVVPKAQKETVK------AEVKKEDEPPEQAEPEPTEAWKDLDKSQEEIKKH 592
V +++ + + + T K A +KEDE E+ + EA DL K++EE+
Sbjct: 408 VDQIKSQEQLAAELAEYTAKIALLEEARRRKEDE-VEEWQHRAKEAQDDLVKTKEEL--- 463
Query: 593 HASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISD 652
+ + + P P P + +S H +L G PTG L + I D
Sbjct: 464 ---------HLVMTAPPPPPPPVYEPVSYHVQ-ESLQDEGAEPTGYSAEL---SSEGIRD 510
Query: 653 NANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNS 687
+ N K + V + T++ E +Q D +
Sbjct: 511 DRNEEKRITEAEKNERVQRQLLTLSSELSQARDEN 545
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 137 bits (345), Expect = 4e-32
Identities = 135/515 (26%), Positives = 229/515 (44%), Gaps = 81/515 (15%)
Query: 228 TWLD-----SAKEIKKQVRGVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAG 281
TWL SA+E++K+ P F F KFYP D A+ L +DIT+ LQ+++ I++
Sbjct: 57 TWLKLDKKVSAQEVRKEN---PLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSD 113
Query: 282 RLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQT--------KELEEKVM 333
+ C T LLGSY +Q++ GDY+ E+H Y+S +L P + + E+++
Sbjct: 114 EIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQ 173
Query: 334 ELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYK--DK 391
H +R M A LE+L+ A+ L MYG++ + K+ +G D+ LGV + GL +Y+ DK
Sbjct: 174 VWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDK 233
Query: 392 LRIN-RFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHH 449
L FPW ++ IS+ F IK P +++ + F P R K++ ++C+ H
Sbjct: 234 LTPKIGFPWSEIRNISFNDKKFVIK--PIDKKAPDFV--FYAPRLRINKRILQLCMGNHE 289
Query: 450 TFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQ-------------------TRQASALID 490
+ R DTI + A + ++ + + Q R+ L+
Sbjct: 290 LYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELML 349
Query: 491 RPAPHFERTASKRASRSL------------DGAAAVDSADRSPRPTSAPAITQGQVAEGG 538
R + E+T K+A R L + A + A+R A + ++
Sbjct: 350 RLQDYEEKT--KKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQA 407
Query: 539 VLDASAKKTVVPKAQKETVK------AEVKKEDEPPEQAEPEPTEAWKDLDKSQEEIKKH 592
V +++ + + + T K A +KEDE E+ + EA DL K++EE+
Sbjct: 408 VDQIKSQEQLAAELAEYTAKIALLEEARRRKEDE-VEEWQHRAKEAQDDLVKTKEEL--- 463
Query: 593 HASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISD 652
+ + + P P P + +S H +L G PTG L + I D
Sbjct: 464 ---------HLVMTAPPPPPPPVYEPVSYHVQ-ESLQDEGAEPTGYSAEL---SSEGIRD 510
Query: 653 NANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNS 687
+ N K + V + T++ E +Q D +
Sbjct: 511 DRNEEKRITEAEKNERVQRQLLTLSSELSQARDEN 545
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 134 bits (336), Expect = 4e-31
Identities = 79/236 (33%), Positives = 124/236 (52%), Gaps = 16/236 (6%)
Query: 229 WLDSAKEIKKQVRGVPWNFT--FNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCS 286
W+D K +KKQ+ T F V FY P +QL ++ITRY LQL++DI+ G +PC+
Sbjct: 77 WVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCT 136
Query: 287 FATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAP----NQTKELEE---KVMELHKSY 339
L +Q++ GD+D + D++ F L P K LEE KV LH+ Y
Sbjct: 137 LEQAIQLAGLAVQADFGDFD-QYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKY 195
Query: 340 RSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLV-YKDKLRINRFP 398
R +T A++ +++ +++ YG + + AKD +G DI +G C G+ V +K+ F
Sbjct: 196 RGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFR 255
Query: 399 WPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRL 454
W + +S+ +S F + E E TI F+ AK +W++CV H F+RL
Sbjct: 256 WHDIANMSHNKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLCVARHKFYRL 306
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 124 bits (311), Expect = 3e-28
Identities = 110/411 (26%), Positives = 188/411 (45%), Gaps = 39/411 (9%)
Query: 228 TWLDSAKEIKKQV--RGVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLP 284
TWL K++ Q + P F F KFYP D ++ L +DIT+ LQ+++ I+ +
Sbjct: 57 TWLKLNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIY 116
Query: 285 CSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKE--------LEEKVMELH 336
C T LL SY +QS+ GD++ E+H Y++ KL P + E EE++ H
Sbjct: 117 CPPETAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWH 176
Query: 337 KSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN- 395
+ +R M A LE+L+ A+ L MYGV+ K+ +G ++ LGV + GL +Y+ R+
Sbjct: 177 EEHRGMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTP 236
Query: 396 --RFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFF 452
FPW ++ IS+ F IK P +++ + F P R K++ +C+ H +
Sbjct: 237 KIGFPWSEIRNISFNDKKFVIK--PIDKKAPDFV--FYAPRLRINKRILALCMGNHELYM 292
Query: 453 RLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAA 512
R DTI + A + ++ Q + A+++ E ++ +
Sbjct: 293 RRRKPDTIEVQQMKAQAREEKH------QKQMERAMLENEKKKREMAEKEKEKIEREKEE 346
Query: 513 AVDSADRSPRPT-SAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQA 571
++ + T A + Q L+ K +AQ E K + KE + E+A
Sbjct: 347 LMERLKQIEEQTKKAQQELEEQTRRALELEQERK-----RAQSEAEK--LAKERQEAEEA 399
Query: 572 EPEPTEAWKDLDKSQE----EIKKHHASISELKKNFMESVPEPRPSEWDKR 618
+ +A +D K+QE E+ + A IS+L+ E EW ++
Sbjct: 400 KEALLQASRDQKKTQEQLALEMAELTARISQLE--MARQKKESEAVEWQQK 448
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 123 bits (309), Expect = 6e-28
Identities = 110/413 (26%), Positives = 193/413 (46%), Gaps = 55/413 (13%)
Query: 228 TWLDSAKEIKKQ--VRGVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLP 284
TWL K++ +Q + P F F KF+P D ++ L ++IT+ LQ+++ I+ +
Sbjct: 57 TWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIY 116
Query: 285 CSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQ-------TKE-LEEKVMELH 336
C T LL SY +Q++ GDY+ E+H Y+++ +L P + TKE EE++ H
Sbjct: 117 CPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWH 176
Query: 337 KSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYK--DKLRI 394
+ +R M + +E+L+ A+ L MYGV+ + K+ +G ++ LGV + GL +Y+ DKL
Sbjct: 177 EEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTP 236
Query: 395 N-RFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFF 452
FPW ++ IS+ F IK P +++ + F P R K++ +C+ H +
Sbjct: 237 KIGFPWSEIRNISFNDKKFVIK--PIDKKAPDFV--FYAPRLRINKRILALCMGNHELYM 292
Query: 453 RLTSTDTIPKSKFLALGSKFRYS---GRTQAQT----------------RQASALIDRPA 493
R DTI + A + ++ R Q + R+ L++R
Sbjct: 293 RRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLK 352
Query: 494 PHFERT--ASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPK 551
E+T A K A +D +R A + + + A A AK+
Sbjct: 353 QIEEQTIKAQKELEEQTRKALELDQ-ERKRAKEEAERLEKERRAAEEAKSAIAKQAADQM 411
Query: 552 AQKETVKAEV--------------KKEDEPPEQAEPEPTEAWKDLDKSQEEIK 590
+E + AE+ KK++E + + + A +DL+K++EE+K
Sbjct: 412 KNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELK 464
Score = 30.8 bits (68), Expect = 5.0
Identities = 23/112 (20%), Positives = 47/112 (41%), Gaps = 18/112 (16%)
Query: 88 KRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDL 147
++ K +++E+E + +E +KE+ K+IE E +K L+
Sbjct: 326 EKKKREIAEKEKERIEREKEELMERLKQIE------------------EQTIKAQKELEE 367
Query: 148 HSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKA 199
+ + E ++ +E+ + KE EE K+ + Q K + +L A
Sbjct: 368 QTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAA 419
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 117 bits (293), Expect = 4e-26
Identities = 88/376 (23%), Positives = 169/376 (44%), Gaps = 18/376 (4%)
Query: 244 PWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSEL 302
P F F KFYP + + L ++IT++ LQ+++ I+ ++ C LL SY +Q++
Sbjct: 91 PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKY 150
Query: 303 GDYDPELHGVDYVSDFKLAPNQTKEL--------EEKVMELHKSYRSMTPAQADLEFLEN 354
GDYDP +H +++ +L P + L EE++ + +R +A++E+L+
Sbjct: 151 GDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKI 210
Query: 355 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKRSS 411
A+ L MYGV+ ++ +G +++LGV + GL +Y + R+ FPW ++ ISY
Sbjct: 211 AQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKE 270
Query: 412 FFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLALGS 470
F IK + + ++ F R K + ++C+ H F R D++ + A
Sbjct: 271 FTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAR 326
Query: 471 KFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAIT 530
+ + + + Q + A +R + + A + A T+
Sbjct: 327 EEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAE 386
Query: 531 QGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDLDKSQEEIK 590
+ Q+ E A+K + + + +KA + +E E + EA K EE +
Sbjct: 387 KAQITEEEA-KLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESE 445
Query: 591 KHHASISELKKNFMES 606
+ +LK++ E+
Sbjct: 446 RRAKEADQLKQDLQEA 461
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 117 bits (293), Expect = 4e-26
Identities = 88/376 (23%), Positives = 169/376 (44%), Gaps = 18/376 (4%)
Query: 244 PWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSEL 302
P F F KFYP + + L ++IT++ LQ+++ I+ ++ C LL SY +Q++
Sbjct: 91 PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKY 150
Query: 303 GDYDPELHGVDYVSDFKLAPNQTKEL--------EEKVMELHKSYRSMTPAQADLEFLEN 354
GDYDP +H +++ +L P + L EE++ + +R +A++E+L+
Sbjct: 151 GDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKI 210
Query: 355 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKRSS 411
A+ L MYGV+ ++ +G +++LGV + GL +Y + R+ FPW ++ ISY
Sbjct: 211 AQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKE 270
Query: 412 FFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLALGS 470
F IK + + ++ F R K + ++C+ H F R D++ + A
Sbjct: 271 FTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAR 326
Query: 471 KFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAIT 530
+ + + + Q + A +R + + A + A T+
Sbjct: 327 EEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAE 386
Query: 531 QGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDLDKSQEEIK 590
+ Q+ E A+K + + + +KA + +E E + EA K EE +
Sbjct: 387 KAQITEEEA-KLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESE 445
Query: 591 KHHASISELKKNFMES 606
+ +LK++ E+
Sbjct: 446 RRAKEADQLKQDLQEA 461
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.127 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,138,314
Number of Sequences: 37866
Number of extensions: 1530860
Number of successful extensions: 9834
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 89
Number of HSP's successfully gapped in prelim test: 409
Number of HSP's that attempted gapping in prelim test: 7909
Number of HSP's gapped (non-prelim): 1903
length of query: 775
length of database: 18,247,518
effective HSP length: 110
effective length of query: 665
effective length of database: 14,082,258
effective search space: 9364701570
effective search space used: 9364701570
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.