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Search of human proteins with 126362949

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|126362949 sodium channel, voltage-gated, type III, alpha
isoform 1 [Homo sapiens]
         (2000 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|126362949 sodium channel, voltage-gated, type III, alpha isof...  3988   0.0  
gi|126362947 sodium channel, voltage-gated, type III, alpha isof...  3868   0.0  
gi|126362955 sodium channel, voltage-gated, type III, alpha isof...  3865   0.0  
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor...  3490   0.0  
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor...  3490   0.0  
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor...  3488   0.0  
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ...  3359   0.0  
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...  3023   0.0  
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo...  2903   0.0  
gi|237512982 voltage-gated sodium channel type V alpha isoform f...  2447   0.0  
gi|30089970 voltage-gated sodium channel type V alpha isoform b ...  2431   0.0  
gi|37622907 voltage-gated sodium channel type V alpha isoform a ...  2429   0.0  
gi|150417967 voltage-gated sodium channel type V alpha isoform c...  2425   0.0  
gi|150417969 voltage-gated sodium channel type V alpha isoform d...  2379   0.0  
gi|237512980 voltage-gated sodium channel type V alpha isoform e...  2358   0.0  
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ...  2105   0.0  
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi...  1817   0.0  
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom...  1308   0.0  
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo...  1292   0.0  
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated...  1011   0.0  
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I...   343   7e-94
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I...   343   7e-94
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...   338   4e-92
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1...   333   8e-91
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H...   333   8e-91
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i...   333   1e-90
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i...   333   1e-90
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i...   333   1e-90
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i...   333   1e-90
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i...   333   1e-90

>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
            [Homo sapiens]
          Length = 2000

 Score = 3988 bits (10342), Expect = 0.0
 Identities = 2000/2000 (100%), Positives = 2000/2000 (100%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60
            MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN
Sbjct: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60

Query: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120
            LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI
Sbjct: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120

Query: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180
            AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL
Sbjct: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180

Query: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
            EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL
Sbjct: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240

Query: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300
            IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD
Sbjct: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300

Query: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360
            SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN
Sbjct: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360

Query: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420
            YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL
Sbjct: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420

Query: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE 480
            AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE
Sbjct: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE 480

Query: 481  LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS 540
            LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS
Sbjct: 481  LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS 540

Query: 541  MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST 600
            MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST
Sbjct: 541  MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST 600

Query: 601  FEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGP 660
            FEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGP
Sbjct: 601  FEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGP 660

Query: 661  SALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELE 720
            SALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELE
Sbjct: 661  SALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELE 720

Query: 721  ESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAME 780
            ESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAME
Sbjct: 721  ESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAME 780

Query: 781  HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG 840
            HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG
Sbjct: 781  HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG 840

Query: 841  LSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 900
            LSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG
Sbjct: 841  LSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 900

Query: 901  MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC 960
            MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC
Sbjct: 901  MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC 960

Query: 961  LIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKN 1020
            LIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKN
Sbjct: 961  LIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKN 1020

Query: 1021 KMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSV 1080
            KMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSV
Sbjct: 1021 KMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSV 1080

Query: 1081 EKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSE 1140
            EKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSE
Sbjct: 1081 EKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSE 1140

Query: 1141 GSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCY 1200
            GSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCY
Sbjct: 1141 GSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCY 1200

Query: 1201 SIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV 1260
            SIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV
Sbjct: 1201 SIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV 1260

Query: 1261 AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG 1320
            AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG
Sbjct: 1261 AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG 1320

Query: 1321 MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN 1380
            MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN
Sbjct: 1321 MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN 1380

Query: 1381 LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE 1440
            LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE
Sbjct: 1381 LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE 1440

Query: 1441 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLG 1500
            NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLG
Sbjct: 1441 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLG 1500

Query: 1501 SKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSR 1560
            SKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSR
Sbjct: 1501 SKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSR 1560

Query: 1561 INLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF 1620
            INLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF
Sbjct: 1561 INLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF 1620

Query: 1621 RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV 1680
            RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV
Sbjct: 1621 RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV 1680

Query: 1681 KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGD 1740
            KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGD
Sbjct: 1681 KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGD 1740

Query: 1741 CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF 1800
            CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF
Sbjct: 1741 CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF 1800

Query: 1801 DPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRV 1860
            DPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRV
Sbjct: 1801 DPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRV 1860

Query: 1861 LGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRL 1920
            LGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRL
Sbjct: 1861 LGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRL 1920

Query: 1921 KNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEK 1980
            KNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEK
Sbjct: 1921 KNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEK 1980

Query: 1981 FEKDKPEKESKGKEVRENQK 2000
            FEKDKPEKESKGKEVRENQK
Sbjct: 1981 FEKDKPEKESKGKEVRENQK 2000


>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
            [Homo sapiens]
          Length = 1951

 Score = 3868 bits (10030), Expect = 0.0
 Identities = 1951/2000 (97%), Positives = 1951/2000 (97%), Gaps = 49/2000 (2%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60
            MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN
Sbjct: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60

Query: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120
            LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI
Sbjct: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120

Query: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180
            AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL
Sbjct: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180

Query: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
            EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL
Sbjct: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240

Query: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300
            IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD
Sbjct: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300

Query: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360
            SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN
Sbjct: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360

Query: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420
            YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL
Sbjct: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420

Query: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE 480
            AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE
Sbjct: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE 480

Query: 481  LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS 540
            LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS
Sbjct: 481  LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS 540

Query: 541  MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST 600
            MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST
Sbjct: 541  MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST 600

Query: 601  FEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGP 660
            FEDSESRRDSLFVPHRHGERRNSN                                    
Sbjct: 601  FEDSESRRDSLFVPHRHGERRNSN------------------------------------ 624

Query: 661  SALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELE 720
                         GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELE
Sbjct: 625  -------------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELE 671

Query: 721  ESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAME 780
            ESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAME
Sbjct: 672  ESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAME 731

Query: 781  HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG 840
            HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG
Sbjct: 732  HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG 791

Query: 841  LSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 900
            LSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG
Sbjct: 792  LSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 851

Query: 901  MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC 960
            MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC
Sbjct: 852  MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC 911

Query: 961  LIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKN 1020
            LIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKN
Sbjct: 912  LIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKN 971

Query: 1021 KMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSV 1080
            KMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSV
Sbjct: 972  KMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSV 1031

Query: 1081 EKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSE 1140
            EKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSE
Sbjct: 1032 EKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSE 1091

Query: 1141 GSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCY 1200
            GSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCY
Sbjct: 1092 GSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCY 1151

Query: 1201 SIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV 1260
            SIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV
Sbjct: 1152 SIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV 1211

Query: 1261 AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG 1320
            AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG
Sbjct: 1212 AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG 1271

Query: 1321 MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN 1380
            MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN
Sbjct: 1272 MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN 1331

Query: 1381 LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE 1440
            LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE
Sbjct: 1332 LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE 1391

Query: 1441 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLG 1500
            NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLG
Sbjct: 1392 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLG 1451

Query: 1501 SKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSR 1560
            SKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSR
Sbjct: 1452 SKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSR 1511

Query: 1561 INLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF 1620
            INLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF
Sbjct: 1512 INLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF 1571

Query: 1621 RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV 1680
            RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV
Sbjct: 1572 RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV 1631

Query: 1681 KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGD 1740
            KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGD
Sbjct: 1632 KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGD 1691

Query: 1741 CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF 1800
            CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF
Sbjct: 1692 CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF 1751

Query: 1801 DPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRV 1860
            DPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRV
Sbjct: 1752 DPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRV 1811

Query: 1861 LGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRL 1920
            LGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRL
Sbjct: 1812 LGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRL 1871

Query: 1921 KNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEK 1980
            KNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEK
Sbjct: 1872 KNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEK 1931

Query: 1981 FEKDKPEKESKGKEVRENQK 2000
            FEKDKPEKESKGKEVRENQK
Sbjct: 1932 FEKDKPEKESKGKEVRENQK 1951


>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
            [Homo sapiens]
          Length = 1951

 Score = 3865 bits (10024), Expect = 0.0
 Identities = 1950/2000 (97%), Positives = 1950/2000 (97%), Gaps = 49/2000 (2%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60
            MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN
Sbjct: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60

Query: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120
            LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI
Sbjct: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120

Query: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180
            AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL
Sbjct: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180

Query: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
            EDFTFLRDPWNWLDFSVIVMAYVTEFV LGNVSALRTFRVLRALKTISVIPGLKTIVGAL
Sbjct: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240

Query: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300
            IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD
Sbjct: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300

Query: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360
            SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN
Sbjct: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360

Query: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420
            YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL
Sbjct: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420

Query: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE 480
            AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE
Sbjct: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE 480

Query: 481  LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS 540
            LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS
Sbjct: 481  LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS 540

Query: 541  MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST 600
            MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST
Sbjct: 541  MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST 600

Query: 601  FEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGP 660
            FEDSESRRDSLFVPHRHGERRNSN                                    
Sbjct: 601  FEDSESRRDSLFVPHRHGERRNSN------------------------------------ 624

Query: 661  SALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELE 720
                         GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELE
Sbjct: 625  -------------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELE 671

Query: 721  ESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAME 780
            ESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAME
Sbjct: 672  ESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAME 731

Query: 781  HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG 840
            HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG
Sbjct: 732  HYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG 791

Query: 841  LSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 900
            LSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG
Sbjct: 792  LSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 851

Query: 901  MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC 960
            MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC
Sbjct: 852  MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC 911

Query: 961  LIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKN 1020
            LIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKN
Sbjct: 912  LIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKN 971

Query: 1021 KMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSV 1080
            KMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSV
Sbjct: 972  KMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSV 1031

Query: 1081 EKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSE 1140
            EKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSE
Sbjct: 1032 EKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSE 1091

Query: 1141 GSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCY 1200
            GSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCY
Sbjct: 1092 GSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCY 1151

Query: 1201 SIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV 1260
            SIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV
Sbjct: 1152 SIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWV 1211

Query: 1261 AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG 1320
            AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG
Sbjct: 1212 AYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEG 1271

Query: 1321 MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN 1380
            MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN
Sbjct: 1272 MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNN 1331

Query: 1381 LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE 1440
            LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE
Sbjct: 1332 LSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEE 1391

Query: 1441 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLG 1500
            NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLG
Sbjct: 1392 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLG 1451

Query: 1501 SKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSR 1560
            SKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSR
Sbjct: 1452 SKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSR 1511

Query: 1561 INLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF 1620
            INLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF
Sbjct: 1512 INLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF 1571

Query: 1621 RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV 1680
            RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV
Sbjct: 1572 RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV 1631

Query: 1681 KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGD 1740
            KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGD
Sbjct: 1632 KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGD 1691

Query: 1741 CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF 1800
            CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF
Sbjct: 1692 CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF 1751

Query: 1801 DPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRV 1860
            DPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRV
Sbjct: 1752 DPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRV 1811

Query: 1861 LGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRL 1920
            LGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRL
Sbjct: 1812 LGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRL 1871

Query: 1921 KNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEK 1980
            KNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEK
Sbjct: 1872 KNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEK 1931

Query: 1981 FEKDKPEKESKGKEVRENQK 2000
            FEKDKPEKESKGKEVRENQK
Sbjct: 1932 FEKDKPEKESKGKEVRENQK 1951


>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 3490 bits (9050), Expect = 0.0
 Identities = 1750/2010 (87%), Positives = 1865/2010 (92%), Gaps = 15/2010 (0%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQ-DNDDENKPKPNSDLEAGK 59
            MAQ++LVPPGP+SFR FTRESLAAIE+R AEEKAK+PK+E+ D DDEN PKPNSDLEAGK
Sbjct: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60

Query: 60   NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRK 119
            +LPFIYGDIPPEMVS PLEDLDPYYINKKTFIV+NKGKAI RFSAT ALYILTP NP+RK
Sbjct: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120

Query: 120  IAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 179
            +AIKILVHSLF+MLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180

Query: 180  LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239
            LEDFTFLRDPWNWLDF+VI  AYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

Query: 240  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTM 299
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP +S+FE N TS+FN ++
Sbjct: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300

Query: 300  DSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNP 359
            D NGT  N T+S FNW +YI D SHFY L+GQ D LLCGN SDAGQCPEGYICVKAGRNP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 360  NYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLI 419
            NYGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 420  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAA-SAASRDFSGIGGL 478
            LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA AAA SA SRDFSG GG+
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
            G   ESSS ASKLSSKS KE +NRRKK++Q+E  +   + + D   KSESEDS++R  F 
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKE--QSGEEEKNDRVRKSESEDSIRRKGFR 538

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
            FS++G+RLT +K+F SPHQSLLSIRGSLFSPRRNS+ S+FSFRGRAKD+GSENDFADDEH
Sbjct: 539  FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598

Query: 599  STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658
            STFED++SRRDSLFVPHRHGERR+SNVSQAS +SR++P LP NGKMHS VDCNGVVSLVG
Sbjct: 599  STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658

Query: 659  GPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEE 718
            GPS LTS  GQL PEGTTTETE+RKRR SSY +SM++LED + RQRA+SIASILTNTMEE
Sbjct: 659  GPSTLTS-AGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEE 717

Query: 719  LEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMA 778
            LEESRQKCPPCWY+FAN+ LIWDCC  WLKVKHLVNL+VMDPFVDLAITICIVLNTLFMA
Sbjct: 718  LEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMA 777

Query: 779  MEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLME 838
            MEHYPMTEQFSSVL+VGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IVSLSLME
Sbjct: 778  MEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLME 837

Query: 839  LGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 898
            LGL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 838  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 897

Query: 899  VGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 958
            VGMQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQT
Sbjct: 898  VGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 957

Query: 959  MCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYV 1018
            MCL VFM+VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGID+V
Sbjct: 958  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFV 1017

Query: 1019 KNKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSG 1073
            K K+RE  QKAF RK K ++  +      NK DSC+SN+T IEI K+LNYL+DGNGTTSG
Sbjct: 1018 KRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSG 1077

Query: 1074 VGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKL 1133
            +G  SSVEKYV+DE+DYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES++EESKEKL
Sbjct: 1078 IG--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKL 1135

Query: 1134 NATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWW 1193
            NATSSSEGSTVD+  P EGEQ E EPEE L+PEACFTE C++KF  CQ+S EEGKGK+WW
Sbjct: 1136 NATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWW 1195

Query: 1194 NLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1253
            NLRKTCY IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL
Sbjct: 1196 NLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1255

Query: 1254 EMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLR 1313
            EMLLKWVAYGFQ YFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPLR
Sbjct: 1256 EMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLR 1315

Query: 1314 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMF 1373
            ALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG MF
Sbjct: 1316 ALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMF 1375

Query: 1374 DISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSR 1430
            D+S VNN S+C+AL    + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR
Sbjct: 1376 DVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSR 1435

Query: 1431 DVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK 1490
            +V+LQP YE+NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK
Sbjct: 1436 NVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK 1495

Query: 1491 KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQ 1550
            KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDDQ
Sbjct: 1496 KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQ 1555

Query: 1551 GKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMI 1610
             + MT +L  INLVFIVLFTGE VLKL+SLR+YYFTIGWNIFDFVVVILSIVGMFLAE+I
Sbjct: 1556 SQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELI 1615

Query: 1611 EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA 1670
            EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA
Sbjct: 1616 EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA 1675

Query: 1671 IFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDT 1730
            IFGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDPD 
Sbjct: 1676 IFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDK 1735

Query: 1731 IHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1790
             HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF
Sbjct: 1736 DHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1795

Query: 1791 EMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL 1850
            EMFYEVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL
Sbjct: 1796 EMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL 1855

Query: 1851 DILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRN 1910
            DILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSYEPITTTLKRKQEEVSA IIQR 
Sbjct: 1856 DILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRA 1915

Query: 1911 FRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSY 1970
            +R YLLKQ++K +SS Y K+  K     PIK+D +IDKLN NSTPEKTD + STTSPPSY
Sbjct: 1916 YRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSY 1975

Query: 1971 DSVTKPDKEKFEKDKPEKESKGKEVRENQK 2000
            DSVTKP+KEKFEKDK EKE KGK++RE++K
Sbjct: 1976 DSVTKPEKEKFEKDKSEKEDKGKDIRESKK 2005


>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 3490 bits (9050), Expect = 0.0
 Identities = 1750/2010 (87%), Positives = 1865/2010 (92%), Gaps = 15/2010 (0%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQ-DNDDENKPKPNSDLEAGK 59
            MAQ++LVPPGP+SFR FTRESLAAIE+R AEEKAK+PK+E+ D DDEN PKPNSDLEAGK
Sbjct: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60

Query: 60   NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRK 119
            +LPFIYGDIPPEMVS PLEDLDPYYINKKTFIV+NKGKAI RFSAT ALYILTP NP+RK
Sbjct: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120

Query: 120  IAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 179
            +AIKILVHSLF+MLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180

Query: 180  LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239
            LEDFTFLRDPWNWLDF+VI  AYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

Query: 240  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTM 299
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP +S+FE N TS+FN ++
Sbjct: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300

Query: 300  DSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNP 359
            D NGT  N T+S FNW +YI D SHFY L+GQ D LLCGN SDAGQCPEGYICVKAGRNP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 360  NYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLI 419
            NYGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 420  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAA-SAASRDFSGIGGL 478
            LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA AAA SA SRDFSG GG+
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
            G   ESSS ASKLSSKS KE +NRRKK++Q+E  +   + + D   KSESEDS++R  F 
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKE--QSGEEEKNDRVRKSESEDSIRRKGFR 538

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
            FS++G+RLT +K+F SPHQSLLSIRGSLFSPRRNS+ S+FSFRGRAKD+GSENDFADDEH
Sbjct: 539  FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598

Query: 599  STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658
            STFED++SRRDSLFVPHRHGERR+SNVSQAS +SR++P LP NGKMHS VDCNGVVSLVG
Sbjct: 599  STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658

Query: 659  GPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEE 718
            GPS LTS  GQL PEGTTTETE+RKRR SSY +SM++LED + RQRA+SIASILTNTMEE
Sbjct: 659  GPSTLTS-AGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEE 717

Query: 719  LEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMA 778
            LEESRQKCPPCWY+FAN+ LIWDCC  WLKVKHLVNL+VMDPFVDLAITICIVLNTLFMA
Sbjct: 718  LEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMA 777

Query: 779  MEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLME 838
            MEHYPMTEQFSSVL+VGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IVSLSLME
Sbjct: 778  MEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLME 837

Query: 839  LGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 898
            LGL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 838  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 897

Query: 899  VGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 958
            VGMQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQT
Sbjct: 898  VGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 957

Query: 959  MCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYV 1018
            MCL VFM+VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGID+V
Sbjct: 958  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFV 1017

Query: 1019 KNKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSG 1073
            K K+RE  QKAF RK K ++  +      NK DSC+SN+T IEI K+LNYL+DGNGTTSG
Sbjct: 1018 KRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSG 1077

Query: 1074 VGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKL 1133
            +G  SSVEKYV+DE+DYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES++EESKEKL
Sbjct: 1078 IG--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKL 1135

Query: 1134 NATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWW 1193
            NATSSSEGSTVD+  P EGEQ E EPEE L+PEACFTE C++KF  CQ+S EEGKGK+WW
Sbjct: 1136 NATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWW 1195

Query: 1194 NLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1253
            NLRKTCY IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL
Sbjct: 1196 NLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1255

Query: 1254 EMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLR 1313
            EMLLKWVAYGFQ YFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPLR
Sbjct: 1256 EMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLR 1315

Query: 1314 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMF 1373
            ALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG MF
Sbjct: 1316 ALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMF 1375

Query: 1374 DISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSR 1430
            D+S VNN S+C+AL    + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR
Sbjct: 1376 DVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSR 1435

Query: 1431 DVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK 1490
            +V+LQP YE+NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK
Sbjct: 1436 NVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK 1495

Query: 1491 KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQ 1550
            KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDDQ
Sbjct: 1496 KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQ 1555

Query: 1551 GKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMI 1610
             + MT +L  INLVFIVLFTGE VLKL+SLR+YYFTIGWNIFDFVVVILSIVGMFLAE+I
Sbjct: 1556 SQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELI 1615

Query: 1611 EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA 1670
            EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA
Sbjct: 1616 EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA 1675

Query: 1671 IFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDT 1730
            IFGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDPD 
Sbjct: 1676 IFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDK 1735

Query: 1731 IHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1790
             HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF
Sbjct: 1736 DHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1795

Query: 1791 EMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL 1850
            EMFYEVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL
Sbjct: 1796 EMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL 1855

Query: 1851 DILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRN 1910
            DILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSYEPITTTLKRKQEEVSA IIQR 
Sbjct: 1856 DILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRA 1915

Query: 1911 FRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSY 1970
            +R YLLKQ++K +SS Y K+  K     PIK+D +IDKLN NSTPEKTD + STTSPPSY
Sbjct: 1916 YRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSY 1975

Query: 1971 DSVTKPDKEKFEKDKPEKESKGKEVRENQK 2000
            DSVTKP+KEKFEKDK EKE KGK++RE++K
Sbjct: 1976 DSVTKPEKEKFEKDKSEKEDKGKDIRESKK 2005


>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
            [Homo sapiens]
          Length = 2005

 Score = 3488 bits (9045), Expect = 0.0
 Identities = 1749/2010 (87%), Positives = 1865/2010 (92%), Gaps = 15/2010 (0%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQ-DNDDENKPKPNSDLEAGK 59
            MAQ++LVPPGP+SFR FTRESLAAIE+R AEEKAK+PK+E+ D DDEN PKPNSDLEAGK
Sbjct: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60

Query: 60   NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRK 119
            +LPFIYGDIPPEMVS PLEDLDPYYINKKTFIV+NKGKAI RFSAT ALYILTP NP+RK
Sbjct: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120

Query: 120  IAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 179
            +AIKILVHSLF+MLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180

Query: 180  LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239
            LEDFTFLRDPWNWLDF+VI  AYVTEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

Query: 240  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTM 299
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP +S+FE N TS+FN ++
Sbjct: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300

Query: 300  DSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNP 359
            D NGT  N T+S FNW +YI D SHFY L+GQ D LLCGN SDAGQCPEGYICVKAGRNP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 360  NYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLI 419
            NYGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 420  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAA-SAASRDFSGIGGL 478
            LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA AAA SA SRDFSG GG+
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
            G   ESSS ASKLSSKS KE +NRRKK++Q+E  +   + + D   KSESEDS++R  F 
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKE--QSGEEEKNDRVRKSESEDSIRRKGFR 538

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
            FS++G+RLT +K+F SPHQSLLSIRGSLFSPRRNS+ S+FSFRGRAKD+GSENDFADDEH
Sbjct: 539  FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598

Query: 599  STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658
            STFED++SRRDSLFVPHRHGERR+SNVSQAS +SR++P LP NGKMHS VDCNGVVSLVG
Sbjct: 599  STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658

Query: 659  GPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEE 718
            GPS LTS  GQL PEGTTTETE+RKRR SSY +SM++LED + RQRA+SIASILTNTMEE
Sbjct: 659  GPSTLTS-AGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEE 717

Query: 719  LEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMA 778
            LEESRQKCPPCWY+FAN+ LIWDCC  WLKVKHLVNL+VMDPFVDLAITICIVLNTLFMA
Sbjct: 718  LEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMA 777

Query: 779  MEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLME 838
            MEHYPMTEQFSSVL+VGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IVSLSLME
Sbjct: 778  MEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLME 837

Query: 839  LGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 898
            LGL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 838  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 897

Query: 899  VGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 958
            VGMQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQT
Sbjct: 898  VGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 957

Query: 959  MCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYV 1018
            MCL VFM+VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGID+V
Sbjct: 958  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFV 1017

Query: 1019 KNKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSG 1073
            K K+RE  QKAF RK K ++  +      NK DSC+SN+T IEI K+LNYL+DGNGTTSG
Sbjct: 1018 KRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSG 1077

Query: 1074 VGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKL 1133
            +G  SSVEKYV+DE+DYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES++EESKEKL
Sbjct: 1078 IG--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKL 1135

Query: 1134 NATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWW 1193
            NATSSSEGSTVD+  P EGEQ E EPEE L+PEACFTE C++KF  CQ+S EEGKGK+WW
Sbjct: 1136 NATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWW 1195

Query: 1194 NLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1253
            NLRKTCY IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL
Sbjct: 1196 NLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1255

Query: 1254 EMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLR 1313
            EMLLKWVAYGFQ YFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPLR
Sbjct: 1256 EMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLR 1315

Query: 1314 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMF 1373
            ALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG MF
Sbjct: 1316 ALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMF 1375

Query: 1374 DISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSR 1430
            D+S VNN S+C+AL    + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR
Sbjct: 1376 DVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSR 1435

Query: 1431 DVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK 1490
            +V+LQP YE+NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK
Sbjct: 1436 NVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK 1495

Query: 1491 KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQ 1550
            KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDDQ
Sbjct: 1496 KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQ 1555

Query: 1551 GKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMI 1610
             + MT +L  INLVFIVLFTGE VLKL+SLR+YYFTIGWNIFDFVVVILSIVGMFLAE+I
Sbjct: 1556 SQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELI 1615

Query: 1611 EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA 1670
            EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA
Sbjct: 1616 EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA 1675

Query: 1671 IFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDT 1730
            IFGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDPD 
Sbjct: 1676 IFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDK 1735

Query: 1731 IHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1790
             HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF
Sbjct: 1736 DHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1795

Query: 1791 EMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL 1850
            EMFYEVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL
Sbjct: 1796 EMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL 1855

Query: 1851 DILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRN 1910
            DILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSYEPITTTLKRKQEEVSA IIQR 
Sbjct: 1856 DILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRA 1915

Query: 1911 FRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSY 1970
            +R YLLKQ++K +SS Y K+  K     PIK+D +IDKLN NSTPEKTD + STTSPPSY
Sbjct: 1916 YRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSY 1975

Query: 1971 DSVTKPDKEKFEKDKPEKESKGKEVRENQK 2000
            DSVTKP+KEKFEKDK EKE KGK++RE++K
Sbjct: 1976 DSVTKPEKEKFEKDKSEKEDKGKDIRESKK 2005


>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
            sapiens]
          Length = 1998

 Score = 3359 bits (8710), Expect = 0.0
 Identities = 1690/2005 (84%), Positives = 1829/2005 (91%), Gaps = 19/2005 (0%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN 60
            M Q +LVPPGP+SF  FTRESLAAIE+R AEEKAK PK ++ +DDEN PKPNSDLEAGKN
Sbjct: 1    MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKN 60

Query: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120
            LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIV+NKGKAIFRFSATSALYILTP NP+RKI
Sbjct: 61   LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKI 120

Query: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL 180
            AIKILVHSLFSMLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKI+ARGFCL
Sbjct: 121  AIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCL 180

Query: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
            EDFTFLRDPWNWLDF+VI  AYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL
Sbjct: 181  EDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240

Query: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD 300
            IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+QWPP++++ E ++    N T++
Sbjct: 241  IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEK-NITVN 299

Query: 301  SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN 360
             NGT +N T+  F+WK YI D  + Y L+G  D LLCGN SDAGQCPEGY+CVKAGRNPN
Sbjct: 300  YNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPN 359

Query: 361  YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL 420
            YGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLIL
Sbjct: 360  YGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLIL 419

Query: 421  AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAA--SRDFSGIGGL 478
            AVVAMAYEEQNQATLEEAEQKEAEFQQM+EQLKKQQE AQ  A A+A+  SR+ S  G L
Sbjct: 420  AVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRL 479

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
             +   SSSEASKLSSKSAKE RNRRKKR+Q+E   G  K E D F KSESEDS++R  F 
Sbjct: 480  SD---SSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDE-DEFQKSESEDSIRRKGFR 535

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
            FS++GNRLT +K++ SPHQSLLSIRGSLFSPRRNS+TS+FSFRGRAKDVGSENDFADDEH
Sbjct: 536  FSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEH 595

Query: 599  STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658
            STFED+ESRRDSLFVP RHGERRNSN+SQ S SSRM+   PANGKMHSTVDCNGVVSLVG
Sbjct: 596  STFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG 655

Query: 659  GPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEE 718
            GPS  TSP GQL PEGTTTETE+RKRR SS+ +SM+ LED S RQRA+SIASILTNT+EE
Sbjct: 656  GPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEE 715

Query: 719  LEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMA 778
            LEESRQKCPPCWY+F+N+FLIWDC   WLKVKH+VNL+VMDPFVDLAITICIVLNTLFMA
Sbjct: 716  LEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMA 775

Query: 779  MEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLME 838
            MEHYPMT+ F++VLTVGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IV+LSL+E
Sbjct: 776  MEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 835

Query: 839  LGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 898
            LGL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 836  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 895

Query: 899  VGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 958
            VGMQLFGKSYK+CVCKI  DC LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQ 
Sbjct: 896  VGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQA 955

Query: 959  MCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYV 1018
            MCL VFM+VMVIGNLVVLNLFLALLLSSFS+DNLAATDDDNEMNNLQIAV RM KG+ YV
Sbjct: 956  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYV 1015

Query: 1019 KNKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSG 1073
            K K+ E  Q++F RK K+++  +      NK DSCMSN+T  EI K+L+YL+D NGTTSG
Sbjct: 1016 KRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTA-EIGKDLDYLKDVNGTTSG 1074

Query: 1074 VGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKL 1133
            +GTGSSVEKY+IDE+DYMSFINNPSLTVTVPIAVGESDFENLNTE+FSSES+LEESKEKL
Sbjct: 1075 IGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKL 1134

Query: 1134 N-ATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIW 1192
            N ++SSSEGSTVD+  P E EQ   EPEE L+PEACFTEGC+++F  CQ++ EEG+GK W
Sbjct: 1135 NESSSSSEGSTVDIGAPVE-EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQW 1193

Query: 1193 WNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFI 1252
            WNLR+TC+ IVEHNWFETFIVFMILLSSGALAFEDIYI+QRKTIKTMLEYADKVFTYIFI
Sbjct: 1194 WNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFI 1253

Query: 1253 LEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPL 1312
            LEMLLKWVAYG+QTYFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPL
Sbjct: 1254 LEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1313

Query: 1313 RALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNM 1372
            RALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG+ 
Sbjct: 1314 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDR 1373

Query: 1373 FDISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1429
            FDI DVNN +DC  L    + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDS
Sbjct: 1374 FDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDS 1433

Query: 1430 RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1489
            R+V+LQP YEE+LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ
Sbjct: 1434 RNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1493

Query: 1490 KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1549
            KKYYNAMKKLGSKKPQKPIPRP NKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD
Sbjct: 1494 KKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1553

Query: 1550 QGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEM 1609
            Q +Y+T +LSRINLVFIVLFTGE VLKL+SLRHYYFTIGWNIFDFVVVILSIVGMFLAE+
Sbjct: 1554 QSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAEL 1613

Query: 1610 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1669
            IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY
Sbjct: 1614 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1673

Query: 1670 AIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPD 1729
            AIFGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP+
Sbjct: 1674 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPN 1733

Query: 1730 TIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1789
             ++PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD
Sbjct: 1734 KVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1793

Query: 1790 FEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1849
            FEMFYEVWEKFDPDATQF+EF KLS FAAAL+PPL + +PNK+QLIAMDLPMVSGDRIHC
Sbjct: 1794 FEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHC 1853

Query: 1850 LDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQR 1909
            LDILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSY+PITTTLKRKQEEVSA IIQR
Sbjct: 1854 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQR 1913

Query: 1910 NFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTS-PP 1968
             +R +LLK+ +K  S  YNK  IKG  +L IK+DMIID++N NS  EKTD + ST + PP
Sbjct: 1914 AYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPP 1973

Query: 1969 SYDSVTKPDKEKFEKDKPEKESKGK 1993
            SYD VTKP  EK E++  ++++KGK
Sbjct: 1974 SYDRVTKPIVEKHEQEGKDEKAKGK 1998


>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score = 3023 bits (7837), Expect = 0.0
 Identities = 1526/2005 (76%), Positives = 1732/2005 (86%), Gaps = 37/2005 (1%)

Query: 4    ALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPF 63
            A+L PPGP+SF  FT++SLA IE+R AE K+K+PK+E+ +DDE  PKP+SDLEAGK LPF
Sbjct: 2    AMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPF 61

Query: 64   IYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIK 123
            IYGDIPP MVSEPLEDLDPYY +KKTFIV+NKGK IFRF+AT ALY+L+P +P+R+I+IK
Sbjct: 62   IYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIK 121

Query: 124  ILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDF 183
            ILVHSLFSMLIMCTILTNC+FMT++NPPDWTKNVEYTFTGIYTFESL+KILARGFC+ +F
Sbjct: 122  ILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEF 181

Query: 184  TFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
            TFLRDPWNWLDF VIV AY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS
Sbjct: 182  TFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 241

Query: 244  VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303
            VKKLSDVMILTVFCLSVFALIGLQLFMGNL++KC                 F  ++++N 
Sbjct: 242  VKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC-----------------FRNSLENNE 284

Query: 304  TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363
            T  ++  +  + +D+     +FY L+G KD LLCG  +D+GQCPEGY CVK GRNP+YGY
Sbjct: 285  TLESIMNTLESEEDF---RKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGY 341

Query: 364  TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423
            TSFDTFSWAFL+LFRLMTQDYWENLYQ TLRAAGKTYMIFFV+VIFLGSFYL+NLILAVV
Sbjct: 342  TSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVV 401

Query: 424  AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLE 483
            AMAYEEQNQA +EEA+QKE EFQQML++LKK+QEEA+A+AAA+A          +G L E
Sbjct: 402  AMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMG-LSE 460

Query: 484  SSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDG 543
            SSSE SKLSSKSAKE RNRRKK+ Q++   G  KG+ +   KSESEDS++R SF   ++G
Sbjct: 461  SSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEG 520

Query: 544  NRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFED 603
            +R   +K+  +P+QS LSIRGSLFS RR+S+TS+FSF+GR +D+GSE +FADDEHS F D
Sbjct: 521  HRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGD 580

Query: 604  SESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSAL 663
            +ESRR SLFVPHR  ERR+SN+SQAS S    P LP NGKMHS VDCNGVVSLV G SAL
Sbjct: 581  NESRRGSLFVPHRPQERRSSNISQASRSP---PMLPVNGKMHSAVDCNGVVSLVDGRSAL 637

Query: 664  TSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESR 723
              P GQL PEGTT +   +KRR SSY +S +ML D + RQRA+S ASILTNT+EELEESR
Sbjct: 638  MLPNGQLLPEGTTNQIH-KKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESR 696

Query: 724  QKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYP 783
            QKCPP WYRFA+ FLIW+C   W+K K  +  IVMDPFVDLAITICIVLNTLFMAMEH+P
Sbjct: 697  QKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHP 756

Query: 784  MTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSN 843
            MTE+F +VL +GNLVFTGIF AEMVLK+IAMDPY YFQ GWNIFD +IV+LSL+EL L++
Sbjct: 757  MTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLAD 816

Query: 844  VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQL 903
            VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQL
Sbjct: 817  VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQL 876

Query: 904  FGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIV 963
            FGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQ MCLIV
Sbjct: 877  FGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIV 936

Query: 964  FMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMR 1023
            +M+VMVIGNLVVLNLFLALLLSSFSSDNL A ++D + NNLQIAV R++KGI+YVK  +R
Sbjct: 937  YMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLR 996

Query: 1024 ECFQKAFFRKPKVI-EIHEGN----KIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGS 1078
            E   KAF +KPK+  EI +      K ++ +SN+T  E+SK  N+L++ +  +   G GS
Sbjct: 997  EFILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKIS---GFGS 1053

Query: 1079 SVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSS 1138
            SV+K++++++D  SFI+NPSLTVTVPIA GESD EN+N EE SS+S+ E SK +LN +SS
Sbjct: 1054 SVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSS 1113

Query: 1139 SEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKT 1198
            SE STVD  LP EGE+AE EP    +PEACFT+GC+++F  CQV+ E GKGKIWWN+RKT
Sbjct: 1114 SECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKT 1173

Query: 1199 CYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK 1258
            CY IVEH+WFE+FIV MILLSSGALAFEDIYIE++KTIK +LEYADK+FTYIFILEMLLK
Sbjct: 1174 CYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLK 1233

Query: 1259 WVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRF 1318
            W+AYG++TYFTNAWCWLDFLIVDVSLV+LVAN LGYS+LG IKSLRTLRALRPLRALSRF
Sbjct: 1234 WIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRF 1293

Query: 1319 EGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDV 1378
            EGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY C+N T G+ F  S V
Sbjct: 1294 EGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQV 1353

Query: 1379 NNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQ 1435
             N S+C AL    +  RWKN+KVNFDNVG GYL+LLQVATFKGW  IMYAAVDS +V  Q
Sbjct: 1354 PNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQ 1413

Query: 1436 PVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1495
            P YE +LYMY+YFV+FIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNA
Sbjct: 1414 PKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNA 1473

Query: 1496 MKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMT 1555
            MKKLGSKKPQKPIPRP NK QG +FD VT Q FDISIM+LICLNMVTMMVE + Q ++MT
Sbjct: 1474 MKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMT 1533

Query: 1556 LVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFV 1615
             VL  IN+VFI+LFTGE VLKL+SLRHYYFT+GWNIFDFVVVI+SIVGMFLA++IE YFV
Sbjct: 1534 EVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFV 1593

Query: 1616 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1675
            SPTLFRVIRLARIGRILRL+KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS
Sbjct: 1594 SPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1653

Query: 1676 NFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGS 1735
            NFAYVKKE GI+DMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP  +HPGS
Sbjct: 1654 NFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGS 1713

Query: 1736 SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1795
            SV+GDCGNPSVGIF+FVSYIIISFLVVVNMYIAVILENFSVATEES EPLSEDDFEMFYE
Sbjct: 1714 SVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYE 1773

Query: 1796 VWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1855
            VWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA
Sbjct: 1774 VWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1833

Query: 1856 FTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYL 1915
            FTKRVLGESGEMD+LR QME+RFM++NPSKVSYEPITTTLKRKQE+VSA +IQR +R Y 
Sbjct: 1834 FTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYR 1893

Query: 1916 LKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTK 1975
            L+Q +KNISS Y K+  +   DL  K+DM  D +N NS+PEKTD +SSTTSPPSYDSVTK
Sbjct: 1894 LRQNVKNISSIYIKDGDRDD-DLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTK 1952

Query: 1976 PDKEKFEKDKPEKESKGKEVRENQK 2000
            PDKEK+E+D+ EKE KGK+ +E++K
Sbjct: 1953 PDKEKYEQDRTEKEDKGKDSKESKK 1977


>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
            sapiens]
          Length = 1980

 Score = 2903 bits (7525), Expect = 0.0
 Identities = 1498/2028 (73%), Positives = 1697/2028 (83%), Gaps = 78/2028 (3%)

Query: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKK----EQDNDDENKPKPNSDLE 56
            MA  LL PPGP+SF+ FT ESLA IE+R AE K KKP K     +++D+++KPKPNSDLE
Sbjct: 1    MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE 60

Query: 57   AGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNP 116
            AGK+LPFIYGDIP  +V+ PLED DPYY+ +KTF+V+N+GK +FRFSAT ALYIL+P N 
Sbjct: 61   AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL 120

Query: 117  VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILAR 176
            +R+IAIKIL+HS+FSM+IMCTILTNCVFMT SNPPDW+KNVEYTFTGIYTFESL+KI+AR
Sbjct: 121  IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR 180

Query: 177  GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTI 236
            GFC++ FTFLRDPWNWLDFSVI+MAY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTI
Sbjct: 181  GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240

Query: 237  VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFN 296
            VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+ WP +           FN
Sbjct: 241  VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPIN-----------FN 289

Query: 297  GTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAG 356
             +   NGT        F+W++YI + ++FY + G  +PLLCGN SDAGQCPEGY C+KAG
Sbjct: 290  ESYLENGT------KGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAG 343

Query: 357  RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLV 416
            RNPNYGYTSFDTFSWAFL+LFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIF+GSFYLV
Sbjct: 344  RNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLV 403

Query: 417  NLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASR------ 470
            NLILAVVAMAYEEQNQATLEEAEQKEAEF+ MLEQLKKQQEEAQA A A++A        
Sbjct: 404  NLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAI 463

Query: 471  DFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESED 530
            +  G  G G    SSSE SKLSSKSAKE RNRRKKR+Q+E  EG  KG+ +   KSESED
Sbjct: 464  EEEGEEGGGSP-RSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESED 522

Query: 531  SVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRG--RAKDVG 588
             ++R +F   +  NR+   +KF   +QSLLSI GS F  R NSK+SIFSFRG  R +D G
Sbjct: 523  GMRRKAF--RLPDNRI--GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPG 578

Query: 589  SENDFADDEHSTFEDSESRRDSLFVPHRHGERRNS-----NVSQASMSSRMVPGLPANGK 643
            SEN+FADDEHST E+SE RRDSLF+P R  ERR+S       SQ S SSR+ P L  + K
Sbjct: 579  SENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVK 638

Query: 644  MHSTVDCNGVVSLVGGPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQ 703
             +STVDCNGVVSL+GGP +     G+L PE TT E E++K+   S  +SM+ L     + 
Sbjct: 639  RNSTVDCNGVVSLIGGPGSHIG--GRLLPEATT-EVEIKKKGPGSLLVSMDQLASYGRKD 695

Query: 704  RAVSIASILTNTM-EELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFV 762
            R  SI S++TNT+ EELEES++KCPPCWY+FAN FLIW+C   W+K+K +VNLIVMDPFV
Sbjct: 696  RINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFV 755

Query: 763  DLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQE 822
            DLAITICIVLNTLFMAMEH+PMT QF  VL VGNLVFTGIFTAEM LK+IAMDPYYYFQE
Sbjct: 756  DLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQE 815

Query: 823  GWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAL 882
            GWNIFDG IVSLSLMEL L++VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAL
Sbjct: 816  GWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAL 875

Query: 883  GNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCG 942
            GNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIN DC LPRWHM+DFFHSFLIVFRVLCG
Sbjct: 876  GNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCG 935

Query: 943  EWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMN 1002
            EWIETMWDCMEVAGQ MCLIVFM+VMVIGNLVVLNLFLALLLSSFS+DNLAATDDD EMN
Sbjct: 936  EWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMN 995

Query: 1003 NLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKI----DSCMSNNTGIEIS 1058
            NLQI+V R++KG+ + K K+   F +A F++ +  E+   +++     +C++N+TG +I 
Sbjct: 996  NLQISVIRIKKGVAWTKLKVH-AFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIH 1054

Query: 1059 KELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTE 1118
            +  ++ ++GNGTTSG+G  SSVEKY+IDE D+MSFINNP+LTV VPIAVGESDFENLNTE
Sbjct: 1055 RNGDFQKNGNGTTSGIG--SSVEKYIIDE-DHMSFINNPNLTVRVPIAVGESDFENLNTE 1111

Query: 1119 EFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFP 1178
            + SSES+ E SK+KL+ TSSSEGST+D+  P   E    +PEE L P+ACFTEGC+++F 
Sbjct: 1112 DVSSESDPEGSKDKLDDTSSSEGSTIDIK-PEVEEVPVEQPEEYLDPDACFTEGCVQRFK 1170

Query: 1179 FCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKT 1238
             CQV+ EEG GK WW LRKTC+ IVEHNWFETFI+FMILLSSGALAFEDIYIEQRKTI+T
Sbjct: 1171 CCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRT 1230

Query: 1239 MLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELG 1298
            +LEYADKVFTYIFILEMLLKW AYGF  +FTNAWCWLDFLIV VSLVSL+ANALGYSELG
Sbjct: 1231 ILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELG 1290

Query: 1299 AIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1358
            AIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA
Sbjct: 1291 AIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1350

Query: 1359 GKFYHCVNMTTGNMFDISDVNNLSDCQAL----GKQARWKNVKVNFDNVGAGYLALLQVA 1414
            GK+++C N T+   F+I DVNN ++C+ L      + RWKNVK+NFDNVGAGYLALLQVA
Sbjct: 1351 GKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVA 1410

Query: 1415 TFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1474
            TFKGWMDIMYAAVDSR    QP YE+N+YMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQ
Sbjct: 1411 TFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1470

Query: 1475 KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMI 1534
            KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+VFDFVT+Q FDI IM+
Sbjct: 1471 KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMM 1530

Query: 1535 LICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDF 1594
            LICLNMVTMMVETD Q K M  +L  INLVF++ FT E VLK+ +LRHYYFTIGWNIFDF
Sbjct: 1531 LICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDF 1590

Query: 1595 VVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPA 1654
            VVVILSIVGMFLA++IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPA
Sbjct: 1591 VVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPA 1650

Query: 1655 LFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGL 1714
            LFNIGLLLFLVMFI++IFGMSNFAYVK EAGIDDMFNFETFGNSMICLFQITTSAGWDGL
Sbjct: 1651 LFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGL 1710

Query: 1715 LAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1774
            L PILN  PPDC  D  HPGS  KGDCGNPSVGIFFFVSYIIISFL+VVNMYIA+ILENF
Sbjct: 1711 LLPILN-RPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENF 1769

Query: 1775 SVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQL 1834
            SVATEESA+PLSEDDFE FYE+WEKFDPDATQFIE+ KL+DFA AL+ PL + KPN ++L
Sbjct: 1770 SVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIEL 1829

Query: 1835 IAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTT 1894
            IAMDLPMVSGDRIHCLDILFAFTKRVLG+SGE+D LR QME+RF+ASNPSKVSYEPITTT
Sbjct: 1830 IAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTT 1889

Query: 1895 LKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNST 1954
            L+RKQEEVSA ++QR +R +L ++      +  NK                    NG + 
Sbjct: 1890 LRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLE------------------NGGTH 1931

Query: 1955 PEKTDGSSSTTSPPSYDSVTKPDKEK---FEKDKPEKESKGKEVRENQ 1999
             EK + + ST S PSYDSVTKP+KEK    E+ + E+  + KEVRE++
Sbjct: 1932 REKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESK 1979


>gi|237512982 voltage-gated sodium channel type V alpha isoform f
            [Homo sapiens]
          Length = 1962

 Score = 2447 bits (6342), Expect = 0.0
 Identities = 1289/2011 (64%), Positives = 1521/2011 (75%), Gaps = 114/2011 (5%)

Query: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDFSVI+MAYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287

Query: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347

Query: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407

Query: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548

Query: 599  STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658
            ST  +SES   SL VP     RR S   Q S  +   PG   +GK +STVDCNGVVSL+G
Sbjct: 549  STAGESESHHTSLLVP--WPLRRTSAQGQPSPGT-SAPGHALHGKKNSTVDCNGVVSLLG 605

Query: 659  -GPSALTSPTGQL--------PPEGTT-TETEVRKRRLSSYQISMEMLEDSSGRQRAVSI 708
             G    TSP   L        PP+ TT +E     + L+S    ++  E+   RQRA+S 
Sbjct: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665

Query: 709  ASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITI 768
             S+LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+
Sbjct: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725

Query: 769  CIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFD 828
            CIVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD
Sbjct: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785

Query: 829  GIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 888
             IIV LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLV
Sbjct: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845

Query: 889  LAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETM 948
            LAIIVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETM
Sbjct: 846  LAIIVFIFAVVGMQLFGKNYSE--LRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETM 903

Query: 949  WDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAV 1008
            WDCMEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 904  WDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLAL 963

Query: 1009 GRMQKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTG------IEISKEL 1061
             R+Q+G+ +VK    + C      R  K   +    ++ SC++           ++    
Sbjct: 964  ARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023

Query: 1062 NYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFS 1121
               R   G   G GT    E                   V VPIAV ESD ++   +E +
Sbjct: 1024 KETRFEEGEQPGQGTPGDPE------------------PVCVPIAVAESDTDDQEEDEEN 1065

Query: 1122 SESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFC 1180
            S    EES ++    S SEGST D+    E  +   +  +D+K PE CFTEGC+++ P C
Sbjct: 1066 SLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCC 1125

Query: 1181 QVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1240
             V T +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +L
Sbjct: 1126 AVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLL 1185

Query: 1241 EYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAI 1300
            EYADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G I
Sbjct: 1186 EYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPI 1245

Query: 1301 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1360
            KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK
Sbjct: 1246 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1305

Query: 1361 FYHCVNMTTGNM-FDISDVNNLSDCQALG--KQARWKNVKVNFDNVGAGYLALLQVATFK 1417
            F  C+N T G++  + + VNN S C++L    +  W  VKVNFDNVGAGYLALLQVATFK
Sbjct: 1306 FGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFK 1365

Query: 1418 GWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1477
            GWMDIMYAAVDSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK
Sbjct: 1366 GWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1425

Query: 1478 FGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILIC 1537
             GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LIC
Sbjct: 1426 LGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLIC 1485

Query: 1538 LNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVV 1597
            LNMVTMMVETDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVV
Sbjct: 1486 LNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVV 1545

Query: 1598 ILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFN 1657
            ILSIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFN
Sbjct: 1546 ILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFN 1605

Query: 1658 IGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1717
            IGLLLFLVMFIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+P
Sbjct: 1606 IGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSP 1665

Query: 1718 ILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1777
            ILN+ PP CDP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVA
Sbjct: 1666 ILNTGPPYCDP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVA 1724

Query: 1778 TEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAM 1837
            TEES EPLSEDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI M
Sbjct: 1725 TEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINM 1784

Query: 1838 DLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKR 1897
            DLPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+R
Sbjct: 1785 DLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRR 1844

Query: 1898 KQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST- 1954
            K EEVSA +IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N + 
Sbjct: 1845 KHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSR 1904

Query: 1955 ---PEKTDGSSSTTSPPSYDSVTKPDKEKFE 1982
               P  +   SST+ PPSYDSVT+   +  +
Sbjct: 1905 PLGPPSSSSISSTSFPPSYDSVTRATSDNLQ 1935


>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
            sapiens]
          Length = 2015

 Score = 2431 bits (6300), Expect = 0.0
 Identities = 1296/2064 (62%), Positives = 1526/2064 (73%), Gaps = 167/2064 (8%)

Query: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDFSVI+MAY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287

Query: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347

Query: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407

Query: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548

Query: 599  STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658
            ST  +SES   SL VP     RR S   Q S  +   PG   +GK +STVDCNGVVSL+G
Sbjct: 549  STAGESESHHTSLLVPWPL--RRTSAQGQPSPGTS-APGHALHGKKNSTVDCNGVVSLLG 605

Query: 659  -GPSALTSPTGQL--------PPEGTTTETEVR-KRRLSSYQISMEMLEDSSGRQRAVSI 708
             G    TSP   L        PP+ TT   E    + L+S    ++  E+   RQRA+S 
Sbjct: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665

Query: 709  ASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITI 768
             S+LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+
Sbjct: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725

Query: 769  CIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFD 828
            CIVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD
Sbjct: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785

Query: 829  GIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 888
             IIV LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLV
Sbjct: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845

Query: 889  LAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETM 948
            LAIIVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETM
Sbjct: 846  LAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETM 903

Query: 949  WDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAV 1008
            WDCMEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 904  WDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLAL 963

Query: 1009 GRMQKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKEL 1061
             R+Q+G+ +VK    + C      R  K   +    ++ SC++           ++    
Sbjct: 964  ARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023

Query: 1062 NYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFEN------- 1114
               R   G   G GT    E                   V VPIAV ESD ++       
Sbjct: 1024 KETRFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEEN 1065

Query: 1115 -LNTEEFSSESELE------------ESKEKLNATSSSE--------------------- 1140
             L TEE SS+ E +             +  +++AT+SSE                     
Sbjct: 1066 SLGTEEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAP 1125

Query: 1141 ------------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEEG 1187
                        GST D+    E  +   +  +D+K PE CFTEGC+++ P C V T + 
Sbjct: 1126 GCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQA 1185

Query: 1188 KGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVF 1247
             GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+F
Sbjct: 1186 PGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMF 1245

Query: 1248 TYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLR 1307
            TY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLR
Sbjct: 1246 TYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLR 1305

Query: 1308 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNM 1367
            ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N 
Sbjct: 1306 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQ 1365

Query: 1368 TTGNM-FDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMY 1424
            T G++  + + VNN S C++L       W  VKVNFDNVGAGYLALLQVATFKGWMDIMY
Sbjct: 1366 TEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMY 1425

Query: 1425 AAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIF 1484
            AAVDSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIF
Sbjct: 1426 AAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIF 1485

Query: 1485 MTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMM 1544
            MTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMM
Sbjct: 1486 MTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMM 1545

Query: 1545 VETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGM 1604
            VETDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG 
Sbjct: 1546 VETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGT 1605

Query: 1605 FLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFL 1664
             L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFL
Sbjct: 1606 VLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFL 1665

Query: 1665 VMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPP 1724
            VMFIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP
Sbjct: 1666 VMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPP 1725

Query: 1725 DCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEP 1784
             CDP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EP
Sbjct: 1726 YCDP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEP 1784

Query: 1785 LSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSG 1844
            LSEDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVSG
Sbjct: 1785 LSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSG 1844

Query: 1845 DRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSA 1904
            DRIHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVSA
Sbjct: 1845 DRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSA 1904

Query: 1905 AIIQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEKT 1958
             +IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    P  +
Sbjct: 1905 MVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSS 1964

Query: 1959 DGSSSTTSPPSYDSVTKPDKEKFE 1982
               SST+ PPSYDSVT+   +  +
Sbjct: 1965 SSISSTSFPPSYDSVTRATSDNLQ 1988


>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
            sapiens]
          Length = 2016

 Score = 2429 bits (6296), Expect = 0.0
 Identities = 1294/2065 (62%), Positives = 1524/2065 (73%), Gaps = 168/2065 (8%)

Query: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDFSVI+MAY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287

Query: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347

Query: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407

Query: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548

Query: 599  STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658
            ST  +SES   SL VP     RR S   Q S  +   PG   +GK +STVDCNGVVSL+G
Sbjct: 549  STAGESESHHTSLLVPWPL--RRTSAQGQPSPGTS-APGHALHGKKNSTVDCNGVVSLLG 605

Query: 659  -GPSALTSPTGQL--------PPEGTTTETEVR-KRRLSSYQISMEMLEDSSGRQRAVSI 708
             G    TSP   L        PP+ TT   E    + L+S    ++  E+   RQRA+S 
Sbjct: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665

Query: 709  ASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITI 768
             S+LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+
Sbjct: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725

Query: 769  CIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFD 828
            CIVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD
Sbjct: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785

Query: 829  GIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 888
             IIV LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLV
Sbjct: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845

Query: 889  LAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETM 948
            LAIIVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETM
Sbjct: 846  LAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETM 903

Query: 949  WDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAV 1008
            WDCMEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 904  WDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLAL 963

Query: 1009 GRMQKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKEL 1061
             R+Q+G+ +VK    + C      R  K   +    ++ SC++           ++    
Sbjct: 964  ARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023

Query: 1062 NYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFS 1121
               R   G   G GT    E                   V VPIAV ESD ++   +E +
Sbjct: 1024 KETRFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEEN 1065

Query: 1122 SESELEESKEK---------------------LNATSSSE-------------------- 1140
            S    EES ++                     ++AT+SSE                    
Sbjct: 1066 SLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQA 1125

Query: 1141 -------------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEE 1186
                         GST D+    E  +   +  +D+K PE CFTEGC+++ P C V T +
Sbjct: 1126 PGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQ 1185

Query: 1187 GKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKV 1246
              GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+
Sbjct: 1186 APGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKM 1245

Query: 1247 FTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTL 1306
            FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTL
Sbjct: 1246 FTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTL 1305

Query: 1307 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVN 1366
            RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N
Sbjct: 1306 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1365

Query: 1367 MTTGNM-FDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIM 1423
             T G++  + + VNN S C++L       W  VKVNFDNVGAGYLALLQVATFKGWMDIM
Sbjct: 1366 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425

Query: 1424 YAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDI 1483
            YAAVDSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDI
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485

Query: 1484 FMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTM 1543
            FMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTM
Sbjct: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTM 1545

Query: 1544 MVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVG 1603
            MVETDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG
Sbjct: 1546 MVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVG 1605

Query: 1604 MFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLF 1663
              L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLF
Sbjct: 1606 TVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLF 1665

Query: 1664 LVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1723
            LVMFIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ P
Sbjct: 1666 LVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGP 1725

Query: 1724 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAE 1783
            P CDP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES E
Sbjct: 1726 PYCDP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1784

Query: 1784 PLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVS 1843
            PLSEDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVS
Sbjct: 1785 PLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVS 1844

Query: 1844 GDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVS 1903
            GDRIHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVS
Sbjct: 1845 GDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVS 1904

Query: 1904 AAIIQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEK 1957
            A +IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    P  
Sbjct: 1905 AMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPS 1964

Query: 1958 TDGSSSTTSPPSYDSVTKPDKEKFE 1982
            +   SST+ PPSYDSVT+   +  +
Sbjct: 1965 SSSISSTSFPPSYDSVTRATSDNLQ 1989


>gi|150417967 voltage-gated sodium channel type V alpha isoform c
            [Homo sapiens]
          Length = 2016

 Score = 2425 bits (6284), Expect = 0.0
 Identities = 1291/2065 (62%), Positives = 1524/2065 (73%), Gaps = 168/2065 (8%)

Query: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDFSVI+MAYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287

Query: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347

Query: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407

Query: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548

Query: 599  STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658
            ST  +SES   SL VP     RR S   Q S  +   PG   +GK +STVDCNGVVSL+G
Sbjct: 549  STAGESESHHTSLLVPWPL--RRTSAQGQPSPGTS-APGHALHGKKNSTVDCNGVVSLLG 605

Query: 659  -GPSALTSPTGQL--------PPEGTTTETEVR-KRRLSSYQISMEMLEDSSGRQRAVSI 708
             G    TSP   L        PP+ TT   E    + L+S    ++  E+   RQRA+S 
Sbjct: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665

Query: 709  ASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITI 768
             S+LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+
Sbjct: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725

Query: 769  CIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFD 828
            CIVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD
Sbjct: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785

Query: 829  GIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 888
             IIV LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLV
Sbjct: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845

Query: 889  LAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETM 948
            LAIIVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETM
Sbjct: 846  LAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETM 903

Query: 949  WDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAV 1008
            WDCMEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 904  WDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLAL 963

Query: 1009 GRMQKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKEL 1061
             R+Q+G+ +VK    + C      R  K   +    ++ SC++           ++    
Sbjct: 964  ARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023

Query: 1062 NYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFS 1121
               R   G   G GT    E                   V VPIAV ESD ++   +E +
Sbjct: 1024 KETRFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEEN 1065

Query: 1122 SESELEESKEK---------------------LNATSSSE-------------------- 1140
            S    EES ++                     ++AT+SSE                    
Sbjct: 1066 SLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQA 1125

Query: 1141 -------------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEE 1186
                         GST D+    E  +   +  +D+K PE CFTEGC+++ P C V T +
Sbjct: 1126 PGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQ 1185

Query: 1187 GKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKV 1246
              GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+
Sbjct: 1186 APGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKM 1245

Query: 1247 FTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTL 1306
            FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTL
Sbjct: 1246 FTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTL 1305

Query: 1307 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVN 1366
            RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N
Sbjct: 1306 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1365

Query: 1367 MTTGNM-FDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIM 1423
             T G++  + + VNN S C++L       W  VKVNFDNVGAGYLALLQVATFKGWMDIM
Sbjct: 1366 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425

Query: 1424 YAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDI 1483
            YAAVDSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDI
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485

Query: 1484 FMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTM 1543
            FMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTM
Sbjct: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTM 1545

Query: 1544 MVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVG 1603
            MVETDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG
Sbjct: 1546 MVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVG 1605

Query: 1604 MFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLF 1663
              L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLF
Sbjct: 1606 TVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLF 1665

Query: 1664 LVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1723
            LVMFIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ P
Sbjct: 1666 LVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGP 1725

Query: 1724 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAE 1783
            P CDP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES E
Sbjct: 1726 PYCDP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1784

Query: 1784 PLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVS 1843
            PLSEDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVS
Sbjct: 1785 PLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVS 1844

Query: 1844 GDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVS 1903
            GDRIHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVS
Sbjct: 1845 GDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVS 1904

Query: 1904 AAIIQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEK 1957
            A +IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    P  
Sbjct: 1905 AMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPS 1964

Query: 1958 TDGSSSTTSPPSYDSVTKPDKEKFE 1982
            +   SST+ PPSYDSVT+   +  +
Sbjct: 1965 SSSISSTSFPPSYDSVTRATSDNLQ 1989


>gi|150417969 voltage-gated sodium channel type V alpha isoform d
            [Homo sapiens]
          Length = 1998

 Score = 2379 bits (6165), Expect = 0.0
 Identities = 1274/2065 (61%), Positives = 1507/2065 (72%), Gaps = 186/2065 (9%)

Query: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDFSVI+MAYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287

Query: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347

Query: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407

Query: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548

Query: 599  STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658
            ST  +SES   SL VP     RR S   Q S  +   PG   +GK +STVDCNGVVSL+G
Sbjct: 549  STAGESESHHTSLLVPWPL--RRTSAQGQPSPGTS-APGHALHGKKNSTVDCNGVVSLLG 605

Query: 659  -GPSALTSPTGQL--------PPEGTTTETEVR-KRRLSSYQISMEMLEDSSGRQRAVSI 708
             G    TSP   L        PP+ TT   E    + L+S    ++  E+   RQRA+S 
Sbjct: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665

Query: 709  ASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITI 768
             S+LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+
Sbjct: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725

Query: 769  CIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFD 828
            CIVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD
Sbjct: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785

Query: 829  GIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 888
             IIV LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLV
Sbjct: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845

Query: 889  LAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETM 948
            LAIIVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETM
Sbjct: 846  LAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETM 903

Query: 949  WDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAV 1008
            WDCMEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 904  WDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLAL 963

Query: 1009 GRMQKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTGI------EISKEL 1061
             R+Q+G+ +VK    + C      R  K   +    ++ SC++           ++    
Sbjct: 964  ARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023

Query: 1062 NYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFS 1121
               R   G   G GT    E                   V VPIAV ESD ++   +E +
Sbjct: 1024 KETRFEEGEQPGQGTPGDPEP------------------VCVPIAVAESDTDDQEEDEEN 1065

Query: 1122 SESELEESKEK---------------------LNATSSSE-------------------- 1140
            S    EES ++                     ++AT+SSE                    
Sbjct: 1066 SLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQA 1125

Query: 1141 -------------GSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEE 1186
                         GST D+    E  +   +  +D+K PE CFTEGC+++ P C V T +
Sbjct: 1126 PGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQ 1185

Query: 1187 GKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKV 1246
              GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+
Sbjct: 1186 APGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKM 1245

Query: 1247 FTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTL 1306
            FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTL
Sbjct: 1246 FTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTL 1305

Query: 1307 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVN 1366
            RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N
Sbjct: 1306 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1365

Query: 1367 MTTGNM-FDISDVNNLSDCQALGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIM 1423
             T G++  + + VNN S C++L       W  VKVNFDNVGAGYLALLQV          
Sbjct: 1366 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQV---------- 1415

Query: 1424 YAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDI 1483
                     + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDI
Sbjct: 1416 --------YEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1467

Query: 1484 FMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTM 1543
            FMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTM
Sbjct: 1468 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTM 1527

Query: 1544 MVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVG 1603
            MVETDDQ      +L++INL+F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG
Sbjct: 1528 MVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVG 1587

Query: 1604 MFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLF 1663
              L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLF
Sbjct: 1588 TVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLF 1647

Query: 1664 LVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1723
            LVMFIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ P
Sbjct: 1648 LVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGP 1707

Query: 1724 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAE 1783
            P CDP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES E
Sbjct: 1708 PYCDP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTE 1766

Query: 1784 PLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVS 1843
            PLSEDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVS
Sbjct: 1767 PLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVS 1826

Query: 1844 GDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVS 1903
            GDRIHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVS
Sbjct: 1827 GDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVS 1886

Query: 1904 AAIIQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEK 1957
            A +IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    P  
Sbjct: 1887 AMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPS 1946

Query: 1958 TDGSSSTTSPPSYDSVTKPDKEKFE 1982
            +   SST+ PPSYDSVT+   +  +
Sbjct: 1947 SSSISSTSFPPSYDSVTRATSDNLQ 1971


>gi|237512980 voltage-gated sodium channel type V alpha isoform e
            [Homo sapiens]
          Length = 1983

 Score = 2358 bits (6112), Expect = 0.0
 Identities = 1268/2064 (61%), Positives = 1500/2064 (72%), Gaps = 199/2064 (9%)

Query: 6    LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
            L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62   PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
            P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122  IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
            +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182  DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
             FTFLRDPWNWLDFSVI+MAYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 242  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287

Query: 302  NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
            NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 288  NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347

Query: 359  PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
            P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 348  PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407

Query: 419  ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
            ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 408  ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453

Query: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
              +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 454  DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509

Query: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
                G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 510  SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548

Query: 599  STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658
            ST  +SES   SL VP     RR S   Q S  +   PG   +GK +STVDCNGVVSL+G
Sbjct: 549  STAGESESHHTSLLVP--WPLRRTSAQGQPSPGT-SAPGHALHGKKNSTVDCNGVVSLLG 605

Query: 659  -GPSALTSPTGQL--------PPEGTT-TETEVRKRRLSSYQISMEMLEDSSGRQRAVSI 708
             G    TSP   L        PP+ TT +E     + L+S    ++  E+   RQRA+S 
Sbjct: 606  AGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSA 665

Query: 709  ASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITI 768
             S+LT+ +EELEESR KCPPCW R A  +LIW+CC  W+ +K  V L+VMDPF DL IT+
Sbjct: 666  VSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITM 725

Query: 769  CIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFD 828
            CIVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD
Sbjct: 726  CIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFD 785

Query: 829  GIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLV 888
             IIV LSLMELGLS +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLV
Sbjct: 786  SIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLV 845

Query: 889  LAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETM 948
            LAIIVFIFAVVGMQLFGK+Y E   + +D   LPRWHM DFFH+FLI+FR+LCGEWIETM
Sbjct: 846  LAIIVFIFAVVGMQLFGKNYSE--LRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETM 903

Query: 949  WDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAV 1008
            WDCMEV+GQ++CL+VF+LVMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+
Sbjct: 904  WDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLAL 963

Query: 1009 GRMQKGIDYVKNKMRE-CFQKAFFRKPKVIEIHEGNKIDSCMSNNTG------IEISKEL 1061
             R+Q+G+ +VK    + C      R  K   +    ++ SC++           ++    
Sbjct: 964  ARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTR 1023

Query: 1062 NYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFE-------- 1113
               R   G   G GT    E                   V VPIAV ESD +        
Sbjct: 1024 KETRFEEGEQPGQGTPGDPE------------------PVCVPIAVAESDTDDQEEDEEN 1065

Query: 1114 NLNTEEFSSESELE------------ESKEKLNATSS----------------------- 1138
            +L TEE SS+ E +             +  +++AT+S                       
Sbjct: 1066 SLGTEEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAP 1125

Query: 1139 ----------SEGSTVDVVLPREGEQAETEPEEDLK-PEACFTEGCIKKFPFCQVSTEEG 1187
                      SEGST D+    E  +   +  +D+K PE CFTEGC+++ P C V T + 
Sbjct: 1126 GCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQA 1185

Query: 1188 KGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVF 1247
             GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYADK+F
Sbjct: 1186 PGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMF 1245

Query: 1248 TYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLR 1307
            TY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLR
Sbjct: 1246 TYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLR 1305

Query: 1308 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNM 1367
            ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N 
Sbjct: 1306 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQ 1365

Query: 1368 TTGNM-FDISDVNNLSDCQALG--KQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMY 1424
            T G++  + + VNN S C++L    +  W  VKVNFDNVGAGYLALLQVATFKGWMDIMY
Sbjct: 1366 TEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMY 1425

Query: 1425 AAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIF 1484
            AAVDSR  + QP +E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIF
Sbjct: 1426 AAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIF 1485

Query: 1485 MTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMM 1544
            MTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMM
Sbjct: 1486 MTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMM 1545

Query: 1545 VETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGM 1604
            VETDDQ      +L++INL+F+ +FT                                G 
Sbjct: 1546 VETDDQSPEKINILAKINLLFVAIFT--------------------------------GT 1573

Query: 1605 FLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFL 1664
             L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFL
Sbjct: 1574 VLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFL 1633

Query: 1665 VMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPP 1724
            VMFIY+IFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP
Sbjct: 1634 VMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPP 1693

Query: 1725 DCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEP 1784
             CDP T+   +  +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EP
Sbjct: 1694 YCDP-TLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEP 1752

Query: 1785 LSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSG 1844
            LSEDDF+MFYE+WEKFDP+ATQFIE+S LSDFA AL  PL IAKPN++ LI MDLPMVSG
Sbjct: 1753 LSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSG 1812

Query: 1845 DRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSA 1904
            DRIHC+DILFAFTKRVLGESGEMDAL+IQME++FMA+NPSK+SYEPITTTL+RK EEVSA
Sbjct: 1813 DRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSA 1872

Query: 1905 AIIQRNFRCYLLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKLNGNST----PEKT 1958
             +IQR FR +LL++ LK+ S  + ++A  G    D P ++ +I   ++ N +    P  +
Sbjct: 1873 MVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSS 1932

Query: 1959 DGSSSTTSPPSYDSVTKPDKEKFE 1982
               SST+ PPSYDSVT+   +  +
Sbjct: 1933 SSISSTSFPPSYDSVTRATSDNLQ 1956


>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
            sapiens]
          Length = 1956

 Score = 2105 bits (5455), Expect = 0.0
 Identities = 1133/2029 (55%), Positives = 1406/2029 (69%), Gaps = 180/2029 (8%)

Query: 13   SFRLFTRESLAAIEKRAAEEKAKKPKKE---QDNDDENKPKPNSDLEAGKNLPFIYGDIP 69
            +FR FT ESL  IEK+ A ++  K  +E   +  D E KP+P  DL+A   LP  YG++P
Sbjct: 12   NFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGELP 71

Query: 70   PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129
             E++ EPLEDLDP+Y   +TF+V+NKG+ I RFSAT AL++ +P N +R+ AIK+ VHS 
Sbjct: 72   AELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSW 131

Query: 130  FSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDP 189
            FS+ I  TIL NCV MT ++ P+    +EY FT IYTFE+LIKILARGFCL +FT+LRDP
Sbjct: 132  FSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYLRDP 188

Query: 190  WNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSD 249
            WNWLDFSVI +AYV   +DL  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKKL+D
Sbjct: 189  WNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLAD 248

Query: 250  VMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVT 309
            V ILT+FCLSVFAL+GLQLF GNL+NKC++                      N   VN  
Sbjct: 249  VTILTIFCLSVFALVGLQLFKGNLKNKCVK----------------------NDMAVN-- 284

Query: 310  MSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTF 369
              T N+  +   D +     G  DPLLCGNGSD+G CP+GYIC+K   NP++ YTSFD+F
Sbjct: 285  -ETTNYSSHRKPDIYINKR-GTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSF 342

Query: 370  SWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEE 429
            +WAFLSLFRLMTQD WE LYQ TLR +GK YMIFFVLVIFLGSFYLVNLILAVV MAYEE
Sbjct: 343  AWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEE 402

Query: 430  QNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEAS 489
            QNQAT +E E KE +FQ+ LE L+K+QE   A+   + +    +G              S
Sbjct: 403  QNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNG--------------S 448

Query: 490  KLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSD 549
             L+SK+A E R+R K R      E N     D + +       +R SFL    G R    
Sbjct: 449  PLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQ-------RRMSFLGLASGKR---- 497

Query: 550  KKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFE-DSESRR 608
                                 R S  S+F FR   +D+       DD    F  D ES R
Sbjct: 498  ---------------------RASHGSVFHFRSPGRDISLPEGVTDD--GVFPGDHESHR 534

Query: 609  DSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSALTSPTG 668
             SL +    G+       Q  +    +P  P+N             S  G       PT 
Sbjct: 535  GSLLLGGGAGQ-------QGPLPRSPLPQ-PSNPD-----------SRHGEDEHQPPPTS 575

Query: 669  QLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPP 728
            +L P G    +     +  ++ +S E L++    QRA+S+ SI+T+ +EELEES QKCPP
Sbjct: 576  ELAP-GAVDVSAFDAGQKKTF-LSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPP 633

Query: 729  CWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQF 788
            C    +  +LIWDCC  W+K+K ++  +V DPF +L IT+CIV+NT+FMAMEH+ M+  F
Sbjct: 634  CLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTF 693

Query: 789  SSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLS 848
             ++L +GN+VFT  FTAEMV KIIA DPYYYFQ+ WNIFD IIV++SL+ELG++    LS
Sbjct: 694  EAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLS 753

Query: 849  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 908
            VLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLT++LAIIVF+FA+VG QL G++Y
Sbjct: 754  VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENY 813

Query: 909  ---KECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFM 965
               ++ +   ++D   PRWHM+DFFHSFLIVFR+LCGEWIE MW CMEV  +++CLI+F+
Sbjct: 814  RNNRKNISAPHED--WPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFL 871

Query: 966  LVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMREC 1025
             VMV+GNLVVLNLF+ALLL+SFS+DNL A +DD E+NNLQ+A+ R+Q      K  +   
Sbjct: 872  TVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSF 931

Query: 1026 FQKAF-FRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYV 1084
            F ++  F +PK          +  +     +  SK  N++     T  G   G    +  
Sbjct: 932  FSRSCPFPQPKA---------EPELVVKLPLSSSKAENHI--AANTARGSSGGLQAPRGP 980

Query: 1085 IDENDYMSFINNPSLTVTVPIAVGESDFENLNT--------------------------- 1117
             DE  +  FI NP++ V+VPIA GESD ++L                             
Sbjct: 981  RDE--HSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVER 1038

Query: 1118 ------------------------EEFSSESELEESKEKLNATSSSEGSTVDVVLPREGE 1153
                                    E +  ES  +   E ++ TSSSEGSTVD + P E  
Sbjct: 1039 CGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEIL 1098

Query: 1154 QAETEPEEDL-KPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFI 1212
            +   E  +DL +P+ CFTEGCI+  P C++ T +    + W +RKTCY IVEH+WFE+FI
Sbjct: 1099 RKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFI 1158

Query: 1213 VFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAW 1272
            +FMILLSSG+LAFED Y++Q+ T+K +LEY D+VFT+IF+ EMLLKWVAYGF+ YFTNAW
Sbjct: 1159 IFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAW 1218

Query: 1273 CWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAI 1332
            CWLDFLIV++SL+SL A  L YSE+  IK+LRTLRALRPLRALSRFEGMRVVV+ALVGAI
Sbjct: 1219 CWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAI 1278

Query: 1333 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTG--NMFDISDVNNLSDCQALGKQ 1390
            PSIMNVLLVCLIFWLIFSIMGVNLFAGKF+ C+N T G  ++  +S VNN SDC+     
Sbjct: 1279 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNST 1338

Query: 1391 AR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYF 1448
                W NVKVNFDNV  GYLALLQVATFKGWMDIMYAAVDSR+V +QP +E+N+YMYLYF
Sbjct: 1339 GSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYF 1398

Query: 1449 VIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1508
            VIFIIFG FFTLNLF+GVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPI
Sbjct: 1399 VIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1458

Query: 1509 PRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVL 1568
            PRP NKFQG VFD VTRQ FDI+IM+LICLNM+TMMVETDDQ +  T +L +IN  F+ +
Sbjct: 1459 PRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAV 1518

Query: 1569 FTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE--KYFVSPTLFRVIRLA 1626
            FTGE V+K+ +LR YYFT GWN+FDF+VV+LSI  +  + +++  + + SPTLFRVIRLA
Sbjct: 1519 FTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLA 1578

Query: 1627 RIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGI 1686
            RIGRILRLI+ AKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGMS+F +V+ EAGI
Sbjct: 1579 RIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGI 1638

Query: 1687 DDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSV 1746
            DDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP+ +   +  +GDCG+P+V
Sbjct: 1639 DDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPN-LPNSNGTRGDCGSPAV 1697

Query: 1747 GIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQ 1806
            GI FF +YIIISFL++VNMYIAVILENF+VATEES EPLSEDDF+MFYE WEKFDP+ATQ
Sbjct: 1698 GIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQ 1757

Query: 1807 FIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGE 1866
            FI FS LSDFA  L  PL I KPN+  LI MDLP+V GD+IHCLDILFAFTK VLGESGE
Sbjct: 1758 FITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGE 1817

Query: 1867 MDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSN 1926
            +D+L+  ME++FMA+N SK SYEPI TTL+ KQE++SA +IQ+ +R Y+L + +   ++ 
Sbjct: 1818 LDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTP 1877

Query: 1927 YNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTK 1975
                A +    LP +  +          P+K++ +S+T+ PPSY+SVT+
Sbjct: 1878 CVPRAEEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPSYESVTR 1926


>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
          Length = 1836

 Score = 1817 bits (4707), Expect = 0.0
 Identities = 925/1290 (71%), Positives = 1063/1290 (82%), Gaps = 20/1290 (1%)

Query: 692  SMEMLEDSSGRQRAVSIA-SILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVK 750
            S++  +   G  R  S   S +++ MEELEE+ QKCPP WY+ A+  LIW+CC  WLK K
Sbjct: 509  SLDTSQGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFK 568

Query: 751  HLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLK 810
            ++++LIVMDPFVDL ITICIVLNTLFMAMEHYPMTE F +VLTVGNLVFTGIFTAEMVLK
Sbjct: 569  NIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLK 628

Query: 811  IIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNM 870
            +IAMDPY YFQ+GWNIFD IIV+LSL+ELGL+NV+GLSVLRSFRLLRVFKLAKSWPTLNM
Sbjct: 629  LIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNM 688

Query: 871  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFF 930
            LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI  DC LPRWHM+DFF
Sbjct: 689  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFF 748

Query: 931  HSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSD 990
            HSFLIVFR+LCGEWIETMWDCMEVAGQ MCL VF++VMVIGNLVVLNLFLALLLSSFS+D
Sbjct: 749  HSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSAD 808

Query: 991  NLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMS 1050
            +LAA+D+D EMNNLQIA+GR++ GI + K  +           PK I +  G    +  +
Sbjct: 809  SLAASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKIL-SPKDIMLSLGEADGAGEA 867

Query: 1051 NNTGIEISKELNY------LRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVP 1104
               G    ++         L+  N   + +G        +  E D+++FINNP LT+ VP
Sbjct: 868  GEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSL--ELDHLNFINNPYLTIQVP 925

Query: 1105 IAVGESDFENLNTEEFSSESELEESK---EKLNATSSSEGSTVDVVLPREG--EQAETEP 1159
            IA  ESD E    EE  + SE E+SK   + L   +SS  ST D   P E   EQAE  P
Sbjct: 926  IASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENP 985

Query: 1160 EEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLS 1219
            E + +PE CFTE C++++P   V   +G+GK WW LR+ C+ IVEHNWFETFIVFMILLS
Sbjct: 986  EGE-QPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLS 1044

Query: 1220 SGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLI 1279
            SGALAFEDIYIEQR+ I+T+LEYADKVFTYIFI+EMLLKWVAYGF+ YFTNAWCWLDFLI
Sbjct: 1045 SGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLI 1104

Query: 1280 VDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1339
            VDVS++SLVAN LGYSELG IKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVL
Sbjct: 1105 VDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVL 1164

Query: 1340 LVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQAL--GKQARWKNVK 1397
            LVCLIFWLIFSIMGVNLFAGKFY+C+N TT   FDIS+VNN S+C++L    Q RW NVK
Sbjct: 1165 LVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVK 1224

Query: 1398 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1457
            VN+DNVG GYL+LLQVATFKGWMDIMYAAVDSR+ + QP YE NLYMYLYFVIFIIFGSF
Sbjct: 1225 VNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSF 1284

Query: 1458 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQG 1517
            FTLNLFIGVIIDNFNQQKKK GG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG
Sbjct: 1285 FTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQG 1344

Query: 1518 MVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKL 1577
            MV+D VT+Q FDI+IMILICLNMVTMMVETD+Q +    +L  IN++FI++FTGE VLK+
Sbjct: 1345 MVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKM 1404

Query: 1578 VSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKG 1637
            ++LR YYFT+GWNIFDFVVVILSIVG+ L+++I+KYFVSPTLFRVIRLARIGR+LRLI+G
Sbjct: 1405 LALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRG 1464

Query: 1638 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGN 1697
            AKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGMSNFAYVKKE+GIDDMFNFETFGN
Sbjct: 1465 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGN 1524

Query: 1698 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1757
            S+ICLF+ITTSAGWDGLL PILNS PPDCDP+  +PG+SVKGDCGNPS+GI FF SYIII
Sbjct: 1525 SIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIII 1584

Query: 1758 SFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFA 1817
            SFL+VVNMYIA+ILENF+VATEES+EPL EDDFEMFYE WEKFDPDATQFI +S+LSDF 
Sbjct: 1585 SFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFV 1644

Query: 1818 AALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDR 1877
              L  PL IAKPNK++LI +DLPMV GD+IHCLDILFA TK VLG+SGEMDAL+  ME++
Sbjct: 1645 DTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEK 1704

Query: 1878 FMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRID 1937
            FMA+NPSKVSYEPITTTLKRK EEV A  IQR +R +LL++ +K  S  Y         D
Sbjct: 1705 FMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDD 1764

Query: 1938 LPIKQDMIIDKLNGNSTPEKTDGSSSTTSP 1967
             P K+ ++ + ++     E  +G+SS+ SP
Sbjct: 1765 APEKEGLLANTMSKMYGHE--NGNSSSPSP 1792



 Score =  698 bits (1802), Expect = 0.0
 Identities = 348/484 (71%), Positives = 396/484 (81%), Gaps = 24/484 (4%)

Query: 6   LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIY 65
           LVP GPE  R FTRESLAAIE+RA EE+A+  + +Q   +E + KP SDLEAGKNLP IY
Sbjct: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPMIY 68

Query: 66  GDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKIL 125
           GD PPE++  PLEDLDPYY NKKTFIV+NKGKAIFRFSAT ALY+L+P + VR+ AIK+L
Sbjct: 69  GDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVL 128

Query: 126 VHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTF 185
           +H+LFSM IM TILTNCVFMT+S+PP W+KNVEYTFTGIYTFESLIKILARGFC++DFTF
Sbjct: 129 IHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTF 188

Query: 186 LRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVK 245
           LRDPWNWLDFSVI+MAY+TEFVDLGN+SALRTFRVLRALKTI+VIPGLKTIVGALIQSVK
Sbjct: 189 LRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVK 248

Query: 246 KLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTF 305
           KLSDVMILTVFCLSVFAL+GLQLFMGNLR KC++WPP  +  +TNTT Y N T   N T+
Sbjct: 249 KLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFN--DTNTTWYSNDTWYGNDTW 306

Query: 306 VN----------------------VTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDA 343
                                    T  TF+W  YI D+ +FY L+G  D LLCGN SDA
Sbjct: 307 YGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDA 366

Query: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403
           G CPEGY C+K GRNPNYGYTS+DTFSWAFL+LFRLMTQDYWENL+QLTLRAAGKTYMIF
Sbjct: 367 GHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIF 426

Query: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVA 463
           FV++IFLGSFYL+NLILAVVAMAY EQN+ATL E ++KE EFQQMLE+ KK QEE +   
Sbjct: 427 FVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAK 486

Query: 464 AASA 467
           AA A
Sbjct: 487 AAQA 490



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 76/340 (22%), Positives = 144/340 (42%), Gaps = 80/340 (23%)

Query: 117  VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNV-----EYT---FTGIYTFE 168
            +R+   KI+ H+ F   I+  IL +   +   +     + V     EY    FT I+  E
Sbjct: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079

Query: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVT------EFVDLGNVSALRTFRVLR 222
             L+K +A GF +    +  + W WLDF ++ ++ ++       + +LG + +LRT R LR
Sbjct: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135

Query: 223  ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP 282
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G           
Sbjct: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY-------- 1187

Query: 283  SDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSD 342
                  T T+  F+ +  +N +     M T                              
Sbjct: 1188 --YCINTTTSERFDISEVNNKSECESLMHT------------------------------ 1215

Query: 343  AGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGK---- 398
             GQ    ++ VK     NY     D     +LSL ++ T   W ++    + +  K    
Sbjct: 1216 -GQV--RWLNVKV----NY-----DNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263

Query: 399  -----TYM-IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432
                  YM ++FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1303



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 46/169 (27%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 1195 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1254
            +R+    ++ H  F  FI+  IL +   +   D     +      +EY    FT I+  E
Sbjct: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171

Query: 1255 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1310
             L+K +A GF     T+  + W WLDF ++      ++A    + +LG I +LRT R LR
Sbjct: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225

Query: 1311 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 50/184 (27%), Positives = 92/184 (50%), Gaps = 17/184 (9%)

Query: 756 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA-- 813
           +++     + I I I+ N +FM M   P   +           FTGI+T E ++KI+A  
Sbjct: 127 VLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYTFESLIKILARG 180

Query: 814 --MDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNML 871
             +D + + ++ WN  D  ++ ++ +     ++  +S LR+FR+LR  K     P L  +
Sbjct: 181 FCVDDFTFLRDPWNWLDFSVIMMAYLT-EFVDLGNISALRTFRVLRALKTITVIPGLKTI 239

Query: 872 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV---CKINDDCTLPRWHMN 927
           +  +  SV  L ++ ++    + +FA+VG+QLF G   ++CV      ND  T   W+ N
Sbjct: 240 VGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFND--TNTTWYSN 297

Query: 928 DFFH 931
           D ++
Sbjct: 298 DTWY 301



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 45/164 (27%), Positives = 84/164 (51%), Gaps = 16/164 (9%)

Query: 124 ILVHSLFSMLIMCTILTNCVFMTLSNPP--DWTKNV----EYTFTGIYTFESLIKILARG 177
           I++     + I   I+ N +FM + + P  +   NV       FTGI+T E ++K++A  
Sbjct: 574 IVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA-- 631

Query: 178 FCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNV---SALRTFRVLRALKTISVIPGLK 234
             ++ + + +  WN  D  ++ ++ V   + L NV   S LR+FR+LR  K     P L 
Sbjct: 632 --MDPYEYFQQGWNIFDSIIVTLSLVE--LGLANVQGLSVLRSFRLLRVFKLAKSWPTLN 687

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCL 278
            ++  +  SV  L ++ ++    + +FA++G+QLF G    +C+
Sbjct: 688 MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730



 Score = 40.4 bits (93), Expect = 0.018
 Identities = 28/119 (23%), Positives = 58/119 (48%), Gaps = 14/119 (11%)

Query: 929  FFHSFLIVFRVLCGEWIETMWDC-MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 987
            F  +FL +FR++  ++ E ++   +  AG+T  +I F++++ +G+  ++NL LA++  ++
Sbjct: 392  FSWAFLALFRLMTQDYWENLFQLTLRAAGKTY-MIFFVVIIFLGSFYLINLILAVVAMAY 450

Query: 988  SSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKID 1046
            +  N A   +D E           Q+ ++  K    E        K K  +  EG + D
Sbjct: 451  AEQNEATLAEDKEKEE------EFQQMLEKFKKHQEE------LEKAKAAQALEGGEAD 497



 Score = 36.2 bits (82), Expect = 0.33
 Identities = 28/129 (21%), Positives = 53/129 (41%), Gaps = 12/129 (9%)

Query: 1370 GNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1429
            GN  D        +C   G+   +     ++D     +LAL ++ T   W ++    + +
Sbjct: 361  GNSSDAGHCPEGYECIKTGRNPNYGYT--SYDTFSWAFLALFRLMTQDYWENLFQLTLRA 418

Query: 1430 RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1489
                         YM ++FV+ I  GSF+ +NL + V+   + +Q +    +D    EE 
Sbjct: 419  AG---------KTYM-IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEF 468

Query: 1490 KKYYNAMKK 1498
            ++     KK
Sbjct: 469  QQMLEKFKK 477



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 16/69 (23%), Positives = 38/69 (55%)

Query: 369 FSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYE 428
           F  +FL +FR++  ++ E ++     A     +  F++V+ +G+  ++NL LA++  ++ 
Sbjct: 747 FFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFS 806

Query: 429 EQNQATLEE 437
             + A  +E
Sbjct: 807 ADSLAASDE 815


>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
            sapiens]
          Length = 1682

 Score = 1308 bits (3385), Expect = 0.0
 Identities = 673/1261 (53%), Positives = 892/1261 (70%), Gaps = 40/1261 (3%)

Query: 668  GQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCP 727
            G    E  T + E++KR   S   S+++LED++ R +            EELE+S++ CP
Sbjct: 425  GNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHK------------EELEKSKKICP 472

Query: 728  PCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQ 787
              WY+FA  FLIW+C   WLK+K  V+ I+M PF DL + ICI+LN  F+ +EHYPM++Q
Sbjct: 473  LYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQ 532

Query: 788  FSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGL 847
             +++L +GNLVF GIFTAEM+ KIIAM PY YFQ GWNIFD +IV   L+EL L+NV G+
Sbjct: 533  TNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGM 592

Query: 848  SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 907
            ++LR FR+LR+FKL K WPT  +L+  + NS  AL +L L+L   +F  A  GM+LFGK+
Sbjct: 593  ALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652

Query: 908  YKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLV 967
            Y+E VC I+ DC LPRWHM+DFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+  +++V
Sbjct: 653  YEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMV 712

Query: 968  MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQ 1027
            ++IGNL+VL LFLAL+ SSFSS      +++NE  NLQ+AV R++KGI+YV  K+    Q
Sbjct: 713  ILIGNLLVLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQ 771

Query: 1028 KAFFRKPKVIEIHEGNK-IDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVID 1086
                  PK    H     +   +S++T  E+S   ++L+D   +       S  EK    
Sbjct: 772  NV----PKDTMDHVNEVYVKEDISDHTLSELSNTQDFLKDKEKS-------SGTEKNAT- 819

Query: 1087 ENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDV 1146
            EN+  S I +PS++ TVPIA GESD ENL+ +E  S+S    SKEK+  +SSSE STVD+
Sbjct: 820  ENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDI 879

Query: 1147 VLPREGEQAET-EPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEH 1205
             +  E E     E  + LK       GC +     Q+S    KGKIW N+RKTC  IVE+
Sbjct: 880  AISEEEEMFYGGERSKHLK------NGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVEN 933

Query: 1206 NWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQ 1265
            NWF+ FI  + LLS+G LAFEDIY++QRKTIK +LEYAD +FTYIFILEMLLKW+AYGF+
Sbjct: 934  NWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFK 993

Query: 1266 TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVV 1325
             YF+N W  LDF++V V  +SL+           +K L +++ LRPLR LS+FE M+VVV
Sbjct: 994  AYFSNGWYRLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVVV 1048

Query: 1326 NALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQ 1385
             AL+      +NV LVCL+ WLIFSIMGV+LFAG+FY C++ T+G  F  S+V N S C+
Sbjct: 1049 RALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCE 1108

Query: 1386 AL--GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLY 1443
            +L   +   W+N K+NFDNVG G+L+LLQVATF GW+ IM +A+DS  V +QP +E N+Y
Sbjct: 1109 SLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIY 1168

Query: 1444 MYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1503
            MY YF+ FIIFG F  L++ I VIIDNFN+ K K GG +IF+T +Q+K Y  +KKL  + 
Sbjct: 1169 MYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYED 1228

Query: 1504 PQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINL 1563
             Q+P+PRP NK QG +FD VT Q F++ +M+LIC   + MM++TD Q   M++ L  IN 
Sbjct: 1229 SQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINS 1288

Query: 1564 VFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1623
            +F++L+T E +LKL++ R +YFTI WNIFDF+VVI SI G+ L   +  Y V P+L ++I
Sbjct: 1289 IFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLI 1348

Query: 1624 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKE 1683
             L+RI  +LRL KG K    L+  LM+SLPAL NI LL+FLVMFIYA+FGM NFAYVKKE
Sbjct: 1349 LLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKE 1408

Query: 1684 AGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGN 1743
            AGI+D+ NFETFGNSM+CLFQ+   AGWDG+L  I NS   DCDPD I+PG+ V+GDCGN
Sbjct: 1409 AGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGN 1468

Query: 1744 PSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPD 1803
            PSVGIF+FVSYI+IS+L++VNMYI V++E  ++A+++  + LSEDDF  F++VW++FDPD
Sbjct: 1469 PSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPD 1528

Query: 1804 ATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGE 1863
             TQ+I+ SKLSDFAAALDPPL +AKPNK QLIA+DLPM  GDRIHCLDIL AFTKRV+G+
Sbjct: 1529 RTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQ 1588

Query: 1864 SGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNI 1923
               M+ +  ++E  F+ +NP K++ EPITTTLKRKQE VSA IIQR ++ Y L++  KN 
Sbjct: 1589 DVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNT 1648

Query: 1924 S 1924
            S
Sbjct: 1649 S 1649



 Score =  418 bits (1075), Expect = e-116
 Identities = 219/458 (47%), Positives = 296/458 (64%), Gaps = 28/458 (6%)

Query: 5   LLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFI 64
           +L  P P+    FT+ES   I++  A       K   ++ +E   KP  DLE GK LPFI
Sbjct: 1   MLASPEPKGLVPFTKESFELIKQHIA-------KTHNEDHEEEDLKPTPDLEVGKKLPFI 53

Query: 65  YGDIPPEMVSEPLEDLDPYYINKK-TFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIK 123
           YG++   MVSEPLED+DPYY  KK TFIV+NK + IFRF+A S L  L+P N +R+  IK
Sbjct: 54  YGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIK 113

Query: 124 ILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDF 183
           +LVH  F + I+ ++L +CVFM+L+N P W   +E T  GIYTFE L+K+ ARG     F
Sbjct: 114 VLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSF 173

Query: 184 TFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
           +FL DPWNWLDFSV V   +  +  L  +  L+T R LR LK I +  GLK++VG LI  
Sbjct: 174 SFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHC 233

Query: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303
           +K+L  V+ILT+F LS+F+LIG+ LFMGNL++KC +WP                  + N 
Sbjct: 234 LKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQE----------------NENE 277

Query: 304 TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363
           T  N T + +    YI +  +FY L+G++  LLCGN +DAGQCPEGY+CVKAG NP+ G+
Sbjct: 278 TLHNRTGNPY----YIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGF 333

Query: 364 TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423
           T+FD+F WA  +LFRLM QDY E LY   L A+GK YMIFFV+V FL SFY+ +L L ++
Sbjct: 334 TNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGIL 393

Query: 424 AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA 461
           AMAYEE+ Q   E +++ E +FQQ  ++L++  E  +A
Sbjct: 394 AMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEA 431



 Score =  140 bits (353), Expect = 1e-32
 Identities = 154/689 (22%), Positives = 293/689 (42%), Gaps = 147/689 (21%)

Query: 1195 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1254
            +R+T   ++ H +F+ FI+  +L+    ++  ++   +     T+L     ++T+  +++
Sbjct: 107  IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162

Query: 1255 MLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRA 1314
            +  + V  G  ++  + W WLDF +    ++      + YS L  I +L+T R LR L+ 
Sbjct: 163  LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216

Query: 1315 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH----------- 1363
            +   +G++ +V  L+  +  ++ V+++ L F  IFS++G+ LF G   H           
Sbjct: 217  IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276

Query: 1364 -CVNMTTGNMFDISDVNNLSDCQALGKQARWKN-------------VK---------VNF 1400
              ++  TGN + I +  N    +         N             VK          NF
Sbjct: 277  ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNF 336

Query: 1401 DNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTL 1460
            D+ G    AL ++   + + +++Y          Q +Y       ++FV+     SF+  
Sbjct: 337  DSFGWALFALFRLMA-QDYPEVLYH---------QILYASGKVYMIFFVVVSFLFSFYMA 386

Query: 1461 NLFIGVIIDNFNQQKKKFGG----------------QDIFMTEEQKKYYNAMKKLGS--- 1501
            +LF+G++   + ++K++ G                 Q+   T+E K     MKK      
Sbjct: 387  SLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPIST 446

Query: 1502 ------------------KKPQKPIPRPANKFQGMVF------------DFVTRQVF--- 1528
                              +K +K  P    KF                 +FV R +    
Sbjct: 447  DTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPF 506

Query: 1529 -DISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHY-YFT 1586
             D+ ++I I LN+  + +E     K    +L+  NLVFI +FT E + K++++  Y YF 
Sbjct: 507  TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ 566

Query: 1587 IGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1646
            +GWNIFD ++V   ++ + LA +            ++RL R+ RI +L K     + L++
Sbjct: 567  VGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMW 618

Query: 1647 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNF--------AYVKKEAGIDDMFNFETFGNS 1698
            +L  S  AL ++ LLLF  +F  A FGM  F         ++ K+  +   ++   F +S
Sbjct: 619  SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQL-PRWHMHDFFHS 677

Query: 1699 MICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIIS 1758
             + +F+I      + L          DC             +    S  I F++  I+I 
Sbjct: 678  FLNVFRILCGEWVETLW---------DC------------MEVAGQSWCIPFYLMVILIG 716

Query: 1759 FLVVVNMYIAVILENFSVATEESAEPLSE 1787
             L+V+ +++A++  +FS   + +AE  +E
Sbjct: 717  NLLVLYLFLALV-SSFSSCKDVTAEENNE 744



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 66/269 (24%), Positives = 119/269 (44%), Gaps = 32/269 (11%)

Query: 19  RESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDIPPEMVSEPLE 78
           ++ +  I K+  E K ++  KE    +E        +E  K  P     I  +   + LE
Sbjct: 401 KQRVGEISKKI-EPKFQQTGKELQEGNETDEAKTIQIEMKKRSP-----ISTDTSLDVLE 454

Query: 79  DLDPYYINKKTFIVMNKGKAI-----FRFSATSALYILTPLNPVRKIAIKILVHSLFS-- 131
           D    +  +     + K K I     ++F+ T  ++  +P     K  +  ++ + F+  
Sbjct: 455 DATLRHKEE-----LEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDL 509

Query: 132 MLIMCTILTNCVFMTLSNPP-----DWTKNV-EYTFTGIYTFESLIKILARGFCLEDFTF 185
            LI+C IL  C F+TL + P     +   N+    F GI+T E + KI+A    +  + +
Sbjct: 510 FLIICIILNVC-FLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGY 564

Query: 186 LRDPWNWLDFSVIVMAYVTE--FVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
            +  WN  D S+IV   + E    ++  ++ LR FR+LR  K     P  + ++ +L  S
Sbjct: 565 FQVGWNIFD-SMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNS 623

Query: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGN 272
              L D+++L    +   A  G++LF  N
Sbjct: 624 WVALKDLVLLLFTFIFFSAAFGMKLFGKN 652



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 47/184 (25%), Positives = 86/184 (46%), Gaps = 17/184 (9%)

Query: 117  VRKIAIKILVHSLFSMLI-MCTILTNCVFMTLSNPPDWTKNV----EYT---FTGIYTFE 168
            +RK   KI+ ++ F   I + T+L+           D  K +    EY    FT I+  E
Sbjct: 923  IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982

Query: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGN--VSALRTFRVLRALKT 226
             L+K +A GF      +  + W  LDF V+V+ +    +      +  L + + LR L+ 
Sbjct: 983  MLLKWMAYGFK----AYFSNGWYRLDF-VVVIVFCLSLIGKTREELKPLISMKFLRPLRV 1037

Query: 227  ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSA 286
            +S    +K +V ALI++     +V ++ +    +F+++G+ LF G    +C+  P S   
Sbjct: 1038 LSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRF-YECID-PTSGER 1095

Query: 287  FETN 290
            F ++
Sbjct: 1096 FPSS 1099



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 34/153 (22%), Positives = 78/153 (50%), Gaps = 11/153 (7%)

Query: 756 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 815
           +++ PF  L I I ++++ +FM++ + P   ++  VL        GI+T E+++K+ A  
Sbjct: 114 VLVHPFFQLFILISVLIDCVFMSLTNLP---KWRPVL---ENTLLGIYTFEILVKLFARG 167

Query: 816 ----PYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNML 871
                + +  + WN  D  +    ++ +  S ++ +  L++ R LR+ K+      L  L
Sbjct: 168 VWAGSFSFLGDPWNWLDFSVTVFEVI-IRYSPLDFIPTLQTARTLRILKIIPLNQGLKSL 226

Query: 872 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 904
           + ++ + +  L  + ++    + IF+++GM LF
Sbjct: 227 VGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259



 Score = 37.4 bits (85), Expect = 0.15
 Identities = 24/87 (27%), Positives = 52/87 (59%), Gaps = 4/87 (4%)

Query: 369 FSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMI-FFVLVIFLGSFYLVNLILAVVAMAY 427
           F  +FL++FR++  ++ E L+   +  AG+++ I F+++VI +G+  ++ L LA+V+ ++
Sbjct: 674 FFHSFLNVFRILCGEWVETLWDC-MEVAGQSWCIPFYLMVILIGNLLVLYLFLALVS-SF 731

Query: 428 EEQNQATLEEAEQKEAEFQQMLEQLKK 454
                 T EE  + +   Q  + ++KK
Sbjct: 732 SSCKDVTAEENNEAK-NLQLAVARIKK 757


>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
            sapiens]
          Length = 1791

 Score = 1292 bits (3344), Expect = 0.0
 Identities = 694/1300 (53%), Positives = 910/1300 (70%), Gaps = 72/1300 (5%)

Query: 667  TGQLPPEGTTTETEVRKR-------RLSSYQISMEMLE---DSSGRQRAVSIASILTNTM 716
            +G+  P G+ ++ + +K+       +  S  +S++  +   D   RQRA+S  SILT TM
Sbjct: 474  SGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITM 533

Query: 717  EELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLF 776
            +E E+S++ C PC    A+ +L+W+CC  WL VK ++  ++ DPF +LAITICI++NT+F
Sbjct: 534  KEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVF 593

Query: 777  MAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSL 836
            +AMEH+ M   F  +L +GNLVFT IF AEM LKIIA+DPY+YF+ GWNIFD I+  LS 
Sbjct: 594  LAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653

Query: 837  MELGLSNVEGLS--VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVF 894
             ++    ++  S   LRSFR+LRVFKLAKSWPTLN LIKIIGNSVGALG+LT+VL I++F
Sbjct: 654  ADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIF 713

Query: 895  IFAVVGMQLFGKSY------KECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETM 948
            IF+VVGMQLFG+S+      K C         L  WHM DF+HSFL+VFR+LCGEWIE M
Sbjct: 714  IFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENM 773

Query: 949  WDCMEVAG--QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAAT-DDDNEMNNLQ 1005
            W+CM+ A    ++C+IVF+L+ VIG LVVLNLF+ALLL+SFS++      + +     +Q
Sbjct: 774  WECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQ 833

Query: 1006 IAVGRMQKGIDYVKNKMRECFQKAFFRK---PKVIEIHEGNKIDS------CMSNNTGIE 1056
            +A+ R ++   +V++ + E F   + RK   P+  E+  G    S       M    G E
Sbjct: 834  LALDRFRRAFCFVRHTL-EHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSE 892

Query: 1057 ISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGES------ 1110
              +EL  L     T       + +     +E+D      + +  +T P    ++      
Sbjct: 893  TQEELGILTSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQE 952

Query: 1111 -------DFENLNTEEFSSESE---LEESKEKLNATSS-SEGSTVDVVLPREGEQAETEP 1159
                     +++  + FS +     +++ ++K + TS  SE ST+D+   ++G     E 
Sbjct: 953  NKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDL---QDGFGWLPEM 1009

Query: 1160 EEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLS 1219
                +PE C  +G    FP C V   +    IWWNLRKTCY IV+H+WFE+FI+F+ILLS
Sbjct: 1010 VPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLS 1069

Query: 1220 SGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLI 1279
            SGAL FED+++E +  I+ +L   D +FT+IFILEM+LKWVA+GF  YFT+AWC LDF+I
Sbjct: 1070 SGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFII 1129

Query: 1280 VDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1339
            V VS+ +L+        L  +KS RTLRALRPLRALS+FEGM+VVVNAL+GAIP+I+NVL
Sbjct: 1130 VIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVL 1182

Query: 1340 LVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVN 1399
            LVCLIFWL+F I+GV  F+GKF  C+N  T ++ + + + N S C++      W N KVN
Sbjct: 1183 LVCLIFWLVFCILGVYFFSGKFGKCIN-GTDSVINYTIITNKSQCES--GNFSWINQKVN 1239

Query: 1400 FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFT 1459
            FDNVG  YLALLQVATFKGWMDI+YAAVDS + + QP +E N   Y+YFV+FIIFGSFFT
Sbjct: 1240 FDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFT 1299

Query: 1460 LNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMV 1519
            LNLFIGVIIDNFNQQ+KK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+V
Sbjct: 1300 LNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLV 1359

Query: 1520 FDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVS 1579
            FD VT Q+FDI I+ LI LNM++MM E+ +Q K M  +L  +N VF+V+FT E ++K+ +
Sbjct: 1360 FDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFA 1419

Query: 1580 LRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFV--SPTLFRVIRLARIGRILRLIKG 1637
            LR YYFT GWN+FD VVV+LSIV   ++ +  +  +   PTLFR++RLARIGRILRL++ 
Sbjct: 1420 LRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRA 1479

Query: 1638 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGN 1697
            A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIYAI GM+ F+ V  E+GIDD+FNF+TF +
Sbjct: 1480 ARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFAS 1539

Query: 1698 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1757
            SM+CLFQI+TSAGWD LL+P+L S    C        +S   +C  P +   +FVSYIII
Sbjct: 1540 SMLCLFQISTSAGWDSLLSPMLRS-KESC--------NSSSENCHLPGIATSYFVSYIII 1590

Query: 1758 SFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFA 1817
            SFL+VVNMYIAVILENF+ ATEES +PL EDDF++FYEVWEKFDP+ATQFI++S LSDFA
Sbjct: 1591 SFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFA 1650

Query: 1818 AALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDR 1877
             AL  PL +AKPNK Q + MDLPMVS DR+HC+DILFAFT RVLG S  +D+++  ME++
Sbjct: 1651 DALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEK 1710

Query: 1878 FMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLK 1917
            FM +NP K  YEPI TT KRK+EE  AAIIQ+ FR Y++K
Sbjct: 1711 FMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK 1750



 Score =  409 bits (1052), Expect = e-113
 Identities = 239/543 (44%), Positives = 318/543 (58%), Gaps = 54/543 (9%)

Query: 9   PGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDI 68
           P   +FR FT +SLAAIEKR A +K KK  K+Q  +   +P+P  DL+A + LP +YGDI
Sbjct: 11  PDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVP-QPRPQLDLKASRKLPKLYGDI 69

Query: 69  PPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHS 128
           P E++ +PLEDLDP+Y N KTF+V+N+ + I+RFSA  AL+I  P N +R +AI++ VHS
Sbjct: 70  PRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHS 129

Query: 129 LFSMLIMCTILTNCVFMTLSNPPDWTKN----VEYTFTGIYTFESLIKILARGFCLEDFT 184
           LFSM I+ T++ NCVFM      +   N     E  FTGIY FE+LIKILARGF L++F+
Sbjct: 130 LFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFS 189

Query: 185 FLRDPWNWLDFSVIVMAYVTEFVDLG-NVSALRTFRVLRALKTISVIPGLKTIVGALIQS 243
           FLRDPWNWLD  VI +A V+    +   +  LRTFRV RALK ISV+  LK IVGAL++S
Sbjct: 190 FLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRS 249

Query: 244 VKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNG 303
           VKKL +V+ILT FCLS+FAL+G QLFMG+L  KC+     D    +N  +Y         
Sbjct: 250 VKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCIS---RDCKNISNPEAY--------- 297

Query: 304 TFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGY 363
                             D  F   +   +  +CG       C   Y C     NP+Y Y
Sbjct: 298 ------------------DHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNY 339

Query: 364 TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV 423
           T+FD F W+FL++FRLMTQD WE LYQ TLR  G   + FF++VIFLGSFYL+NL LAVV
Sbjct: 340 TNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVV 399

Query: 424 AMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLE 483
            MAYEEQN+    E E KE  FQ+  + LK+++E   A+              G+     
Sbjct: 400 TMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALVAM--------------GIDRSSL 445

Query: 484 SSSEASKLSSKSAKEWRNRRKK----RRQREHLEGNNKGERDSFPKSESEDSVKRSSFLF 539
           +S E S  + K  K + N+++K    R   +     +  + D   K +  +  KR S   
Sbjct: 446 TSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNL 505

Query: 540 SMD 542
           S+D
Sbjct: 506 SLD 508



 Score =  100 bits (250), Expect = 1e-20
 Identities = 78/338 (23%), Positives = 151/338 (44%), Gaps = 50/338 (14%)

Query: 1194 NLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1253
            ++R     +  H+ F  FI+  ++++   +A        + +     + A+ VFT I+I 
Sbjct: 117  SIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPA----KNSNSNNTDIAECVFTGIYIF 172

Query: 1254 EMLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1309
            E L+K +A GF     ++  + W WLD +++ +++VS +           +  LRT R  
Sbjct: 173  EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVF 227

Query: 1310 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF------YH 1363
            R L+A+S    ++V+V AL+ ++  ++NV+++      IF+++G  LF G          
Sbjct: 228  RALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRD 287

Query: 1364 CVNMTTGNMFD--ISDVNNLSDCQALG---------KQARWKNVKV-------NFDNVGA 1405
            C N++    +D       N  + +  G          Q   K+ K+       NFDN G 
Sbjct: 288  CKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGW 347

Query: 1406 GYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIG 1465
             +LA+ ++ T   W  +            Q +    LY   +F++ I  GSF+ +NL + 
Sbjct: 348  SFLAMFRLMTQDSWEKLYQ----------QTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397

Query: 1466 VIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1503
            V+   + +Q K    +   +  ++K +  A + L  +K
Sbjct: 398  VVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 81/338 (23%), Positives = 141/338 (41%), Gaps = 88/338 (26%)

Query: 117  VRKIAIKILVHSLFSMLIMCTILTNC---VF--MTLSNPPDWTKNVEYT---FTGIYTFE 168
            +RK   +I+ HS F   I+  IL +    +F  + L N P   + +  T   FT I+  E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104

Query: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTIS 228
             ++K +A GF      +    W  LDF +IV+  VT  ++L  + + RT R LR L+ +S
Sbjct: 1105 MVLKWVAFGFG----KYFTSAWCCLDF-IIVIVSVTTLINLMELKSFRTLRALRPLRALS 1159

Query: 229  VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFE 288
               G+K +V ALI ++  + +V+++ +    VF ++G+  F G    KC+          
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI---------- 1208

Query: 289  TNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPE 348
                   NGT     + +N T+ T                             +  QC  
Sbjct: 1209 -------NGT----DSVINYTIIT-----------------------------NKSQCES 1228

Query: 349  GYICVKAGRNPNYGY----TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYM--- 401
            G          N+ +     +FD    A+L+L ++ T   W ++    + +  K      
Sbjct: 1229 G----------NFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEF 1278

Query: 402  -------IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432
                   I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 1279 ESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQK 1316



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 61/275 (22%), Positives = 122/275 (44%), Gaps = 59/275 (21%)

Query: 770 IVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA----MDPYYYFQEGWN 825
           +++N +FMA    P     S+   +   VFTGI+  E ++KI+A    +D + + ++ WN
Sbjct: 139 VIINCVFMATG--PAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196

Query: 826 IFDGIIVSLSLMELGLSNVEGLSV----LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGA 881
             D I++ ++++    S + G+++    LR+FR+ R  K       L +++  +  SV  
Sbjct: 197 WLDSIVIGIAIV----SYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKK 252

Query: 882 LGNLTLVLAIIVFIFAVVGMQLF------------------GKSYKEC------------ 911
           L N+ ++    + IFA+VG QLF                   ++Y  C            
Sbjct: 253 LVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKM 312

Query: 912 --------VCKINDDCTLPR-------WHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAG 956
                    C I  +C   +        + ++F  SFL +FR++  +  E ++       
Sbjct: 313 CGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTT 372

Query: 957 QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDN 991
               +  F++V+ +G+  ++NL LA++  ++   N
Sbjct: 373 GLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQN 407



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 44/174 (25%), Positives = 84/174 (48%), Gaps = 22/174 (12%)

Query: 113  PLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLS--NPPDWTKNV----EYTFTGIYT 166
            PLN  + +   I+   +F ++I+  I+ N + M     N P   K++     + F  I+T
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFT 1410

Query: 167  FESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVD-LGN----------VSAL 215
             E LIKI    F L  + F  + WN  D  V++++ V+  +  L N             +
Sbjct: 1411 LECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIV 1465

Query: 216  RTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
            R  R+ R L+ +    G++T++ AL+ S+  L ++ +L    + ++A++G+  F
Sbjct: 1466 RLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1519



 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 44/166 (26%), Positives = 78/166 (46%), Gaps = 21/166 (12%)

Query: 117 VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPP-----DWTKNV-EYTFTGIYTFESL 170
           V+K+   ++      + I   I+ N VF+ + +       +   N+    FT I+  E  
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625

Query: 171 IKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA-------LRTFRVLRA 223
           +KI+A    L+ + + R  WN  D  V +++    F D+ N          LR+FRVLR 
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLS----FADVMNCVLQKRSWPFLRSFRVLRV 677

Query: 224 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
            K     P L T++  +  SV  L  + ++ V  + +F+++G+QLF
Sbjct: 678 FKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 67/368 (18%), Positives = 132/368 (35%), Gaps = 97/368 (26%)

Query: 1511 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFT 1570
            P N  + +        +F + I+  + +N V M              ++    VF  ++ 
Sbjct: 114  PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYI 171

Query: 1571 GEFVLKLVS----LRHYYFTIG-WNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRL 1625
             E ++K+++    L  + F    WN  D +V+ ++IV       I+           +R 
Sbjct: 172  FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRT 223

Query: 1626 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-------- 1677
             R+ R L+ I     ++ ++ AL+ S+  L N+ +L F  + I+A+ G   F        
Sbjct: 224  FRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC 283

Query: 1678 ----------------AYVKKEAGID----------------------------DMFNFE 1693
                             + KKE   +                            +  NF+
Sbjct: 284  ISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFD 343

Query: 1694 TFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVS 1753
             FG S + +F++ T   W+ L    L +                          +FFF+ 
Sbjct: 344  NFGWSFLAMFRLMTQDSWEKLYQQTLRT---------------------TGLYSVFFFIV 382

Query: 1754 YIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKL 1813
             I +    ++N+ +AV+    ++A EE  + ++ +      E  EK   +A Q ++  K 
Sbjct: 383  VIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLKEEKE 433

Query: 1814 SDFAAALD 1821
            +  A  +D
Sbjct: 434  ALVAMGID 441



 Score = 35.4 bits (80), Expect = 0.56
 Identities = 39/136 (28%), Positives = 61/136 (44%), Gaps = 28/136 (20%)

Query: 358  NPNYGYT---SFDTFSWAFLSLFRLMTQDYWENLYQLTLRA---------------AGKT 399
            NP  G     +F TF+ + L LF++ T   W++L    LR+                  +
Sbjct: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582

Query: 400  YMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQK--EAEFQQMLEQLKKQQE 457
            Y + ++++ FL    +VN+ +AV+    E  N AT EE+E    E +F    E  +K   
Sbjct: 1583 YFVSYIIISFL---IVVNMYIAVI---LENFNTAT-EESEDPLGEDDFDIFYEVWEKFDP 1635

Query: 458  EAQAVAAASAASRDFS 473
            EA      SA S DF+
Sbjct: 1636 EATQFIKYSALS-DFA 1650


>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
            type V, alpha (long QT syndrome 3) [Homo sapiens]
          Length = 1637

 Score = 1011 bits (2614), Expect = 0.0
 Identities = 538/847 (63%), Positives = 623/847 (73%), Gaps = 66/847 (7%)

Query: 975  VLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRE-CFQKAFFRK 1033
            VLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+Q+G+ +VK    + C      R 
Sbjct: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690

Query: 1034 PKVIEIHEGNKIDSCMSNNTGI------EISKELNYLRDGNGTTSGVGTGSSVEKYVIDE 1087
             K   +    ++ SC++           ++       R   G   G GT    E      
Sbjct: 691  QKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----- 745

Query: 1088 NDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVV 1147
                         V VPIAV ESD ++   +E +S    EES ++  +   S G      
Sbjct: 746  -------------VCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGP----- 787

Query: 1148 LPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNW 1207
                    E  P+     +   T          + S  +   +  W          E   
Sbjct: 788  --------EAPPDSRTWSQVSATASSE-----AEASASQADWRQQWKAEPQAPGCGE--- 831

Query: 1208 FETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTY 1267
                            AFEDIY+E+RKTIK +LEYADK+FTY+F+LEMLLKWVAYGF+ Y
Sbjct: 832  ----------------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKY 875

Query: 1268 FTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA 1327
            FTNAWCWLDFLIVDVSLVSLVAN LG++E+G IKSLRTLRALRPLRALSRFEGMRVVVNA
Sbjct: 876  FTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNA 935

Query: 1328 LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNM-FDISDVNNLSDCQA 1386
            LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  C+N T G++  + + VNN S C++
Sbjct: 936  LVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCES 995

Query: 1387 LGKQAR--WKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYM 1444
            L       W  VKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSR  + QP +E NLYM
Sbjct: 996  LNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYM 1055

Query: 1445 YLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP 1504
            Y+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKP
Sbjct: 1056 YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKP 1115

Query: 1505 QKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLV 1564
            QKPIPRP NK+QG +FD VT+Q FD++IM LICLNMVTMMVETDDQ      +L++INL+
Sbjct: 1116 QKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLL 1175

Query: 1565 FIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIR 1624
            F+ +FTGE ++KL +LRHYYFT  WNIFDFVVVILSIVG  L+++I+KYF SPTLFRVIR
Sbjct: 1176 FVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIR 1235

Query: 1625 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEA 1684
            LARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFAYVK EA
Sbjct: 1236 LARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA 1295

Query: 1685 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNP 1744
            GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+ PP CDP T+   +  +GDCG+P
Sbjct: 1296 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDP-TLPNSNGSRGDCGSP 1354

Query: 1745 SVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1804
            +VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSEDDF+MFYE+WEKFDP+A
Sbjct: 1355 AVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEA 1414

Query: 1805 TQFIEFS 1811
            TQFIE+S
Sbjct: 1415 TQFIEYS 1421



 Score =  697 bits (1799), Expect = 0.0
 Identities = 390/673 (57%), Positives = 465/673 (69%), Gaps = 67/673 (9%)

Query: 6   LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDN----DDENKPKPNSDLEAGKNL 61
           L+P G  SFR FTRESLAAIEKR AE++A+     Q++     +E  P+P  DL+A K L
Sbjct: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 62  PFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIA 121
           P +YG+ P E++ EPLEDLDP+Y  +KTFIV+NKGK IFRFSAT+ALY+L+P +P+R+ A
Sbjct: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 122 IKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 181
           +KILVHSLF+MLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 182 DFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
            FTFLRDPWNWLDFSVI+MAY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 242 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDS 301
           QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+        
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTAL------- 287

Query: 302 NGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
           NGT  +V      W+    Y+ D  ++ + +G  D LLCGN SDAG CPEGY C+KAG N
Sbjct: 288 NGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGEN 347

Query: 359 PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
           P++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYLVNL
Sbjct: 348 PDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNL 407

Query: 419 ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478
           ILAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                 I G+
Sbjct: 408 ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALT--------------IRGV 453

Query: 479 GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538
             +  SS E S L+  ++ E R++R+KR       G  +   D  PKS+SED  +  + L
Sbjct: 454 DTVSRSSLEMSPLAPVNSHERRSKRRKRMS----SGTEECGEDRLPKSDSEDGPRAMNHL 509

Query: 539 FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598
               G   TS K                    R+S+ SIF+FR R  D+GSE DFADDE+
Sbjct: 510 SLTRGLSRTSMKP-------------------RSSRGSIFTFRRR--DLGSEADFADDEN 548

Query: 599 STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658
           ST  +SES   SL VP     RR S   Q S  +   PG   +GK +STVDCNGVVSL+G
Sbjct: 549 STAGESESHHTSLLVP--WPLRRTSAQGQPSPGT-SAPGHALHGKKNSTVDCNGVVSLLG 605

Query: 659 -GPSALTSPTGQL 670
            G    TSP   L
Sbjct: 606 AGDPEATSPGSHL 618



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 85/350 (24%), Positives = 152/350 (43%), Gaps = 73/350 (20%)

Query: 1195 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1254
            +R+    I+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171

Query: 1255 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1310
             L+K +A GF     T+  + W WLDF ++      ++A    + +LG + +LRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225

Query: 1311 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH-CV---- 1365
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   H CV    
Sbjct: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1366 --NMTTGNM--------------------------FDISDVNNLSDCQALGKQARWKNVK 1397
              N T G++                           D+    N SD     +  R     
Sbjct: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345

Query: 1398 VN-------FDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVI 1450
             N       FD+    +LAL ++ T   W  +    + S            +YM ++F++
Sbjct: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395

Query: 1451 FIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE-QKKYYNAMKKL 1499
             I  GSF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 396  VIFLGSFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 70/273 (25%), Positives = 132/273 (48%), Gaps = 40/273 (14%)

Query: 756  IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMD 815
            IV     D+ I   I LN + M +E    + +  ++L   NL+F  IFT E ++K+ A+ 
Sbjct: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL- 1191

Query: 816  PYYYFQEGWNIFDGIIVSLSLMELGLSNV--------EGLSVLRSFRLLRVFKLAKSWPT 867
             +YYF   WNIFD ++V LS++   LS++            V+R  R+ R+ +L +    
Sbjct: 1192 RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251

Query: 868  LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMN 927
            +  L+  +  S+ AL N+ L+L +++FI+++ GM  F  +Y +    I+D      ++  
Sbjct: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGIDD-----MFNFQ 1304

Query: 928  DFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC--------------------LIVFMLV 967
             F +S L +F++      + +   +   G   C                    ++ F   
Sbjct: 1305 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTY 1364

Query: 968  MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNE 1000
            ++I  L+V+N+++A++L +FS     AT++  E
Sbjct: 1365 IIISFLIVVNMYIAIILENFS----VATEESTE 1393



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 64/279 (22%), Positives = 120/279 (43%), Gaps = 53/279 (18%)

Query: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVT------EFVDLGNVSA 214
            FT ++  E L+K +A GF      +  + W WLDF ++ ++ V+       F ++G + +
Sbjct: 855  FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910

Query: 215  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 274
            LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 911  LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969

Query: 275  NKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDP 334
             +C+     D     N T   N    S    +N+T   +  K  +  D+           
Sbjct: 970  GRCINQTEGD--LPLNYTIVNN---KSQCESLNLTGELYWTKVKVNFDN----------- 1013

Query: 335  LLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWE-NLYQLTL 393
                          GY+ +         +  +    +A +       Q  WE NLY    
Sbjct: 1014 -----------VGAGYLALLQVAT----FKGWMDIMYAAVDSRGYEEQPQWEYNLYM--- 1055

Query: 394  RAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432
                    I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 1056 -------YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 49/237 (20%), Positives = 105/237 (44%), Gaps = 39/237 (16%)

Query: 791  VLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL-----GLSNVE 845
            +L   + +FT +F  EM+LK +A     YF   W   D +IV +SL+ L     G + + 
Sbjct: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906

Query: 846  GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 905
             +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966

Query: 906  KSYKECVCKINDDC------------------------TLPRWHMNDFFHSFLIVFRVLC 941
              +  C+ +   D                         T  + + ++    +L + +V  
Sbjct: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026

Query: 942  GE-WIETMWDCMEVAG---------QTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 988
             + W++ M+  ++  G              I F++ ++ G+   LNLF+ +++ +F+
Sbjct: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1083



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 45/164 (27%), Positives = 81/164 (49%), Gaps = 16/164 (9%)

Query: 756 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA-- 813
           I++    ++ I   I+ N +FMA    P   ++          FT I+T E ++KI+A  
Sbjct: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYTFESLVKILARG 180

Query: 814 --MDPYYYFQEGWNIFDG--IIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLN 869
             +  + + ++ WN  D   II++ +   + L NV   S LR+FR+LR  K       L 
Sbjct: 181 FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNV---SALRTFRVLRALKTISVISGLK 237

Query: 870 MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 912
            ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 238 TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 40/172 (23%), Positives = 73/172 (42%), Gaps = 20/172 (11%)

Query: 113  PLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYT------FTGIYT 166
            PLN  +     I+    F + IM  I  N V M +       + +         F  I+T
Sbjct: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1181

Query: 167  FESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYV---------TEFVDLGNVSALRT 217
             E ++K+ A    L  + F    WN  DF V++++ V           F        +R 
Sbjct: 1182 GECIVKLAA----LRHYYFTNS-WNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRL 1236

Query: 218  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             R+ R L+ I    G++T++ AL+ S+  L ++ +L    + ++++ G+  F
Sbjct: 1237 ARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1288



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 22/95 (23%), Positives = 48/95 (50%), Gaps = 6/95 (6%)

Query: 927  NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSS 986
            + F  +FL +FR++  +  E ++     +   + +I FMLV+ +G+  ++NL LA++  +
Sbjct: 356  DSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMA 415

Query: 987  FSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNK 1021
            +   N A   +  E         R Q+ ++ +K +
Sbjct: 416  YEEQNQATIAETEEKEK------RFQEAMEMLKKE 444



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 41/164 (25%), Positives = 63/164 (38%), Gaps = 36/164 (21%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTY---------------------MIF 403
            +F TF+ + L LF++ T   W+ L    L   G  Y                     ++F
Sbjct: 1302 NFQTFANSMLCLFQITTSAGWDGLLSPILN-TGPPYCDPTLPNSNGSRGDCGSPAVGILF 1360

Query: 404  FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQ-KEAEFQQMLEQLKKQQEEAQAV 462
            F   I +    +VN+ +A++    E  + AT E  E   E +F    E  +K   EA   
Sbjct: 1361 FTTYIIISFLIVVNMYIAII---LENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQF 1417

Query: 463  AAASAASR-----DFSGIGG-----LGELLESSSEASKLSSKSA 496
               S  +R     D S  G      L  LL    E ++L+S +A
Sbjct: 1418 IEYSCGTRFNCPSDISPSGNPIFVDLHALLSRLGELTELASPAA 1461


>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform b [Homo sapiens]
          Length = 2188

 Score =  343 bits (881), Expect = 7e-94
 Identities = 212/622 (34%), Positives = 344/622 (55%), Gaps = 36/622 (5%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1255
            R  C +I+ H  F+  ++  I L+   +A E   IE   T +  L  ++ +FT IF+ EM
Sbjct: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184

Query: 1256 LLKWVA----YGFQTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1308
             LK V+    +G Q Y  ++W  LD  +V VS++ +V   A+A G   LG ++ LR LR 
Sbjct: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244

Query: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYHC+ + 
Sbjct: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVD 1304

Query: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
            T N      + N SDC A     RW + K NFDN+G   ++L  +A+  GW++IMY  +D
Sbjct: 1305 TRN------ITNRSDCMA--ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLD 1356

Query: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1488
            +  V  QPV   N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++    EE
Sbjct: 1357 AVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1416

Query: 1489 QKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD 1548
              K    ++K   K  + P        + ++    T    DI I  +ICLN+VTM +E  
Sbjct: 1417 --KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHY 1474

Query: 1549 DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL-RHYYFTIGWNIFDFVVVILSIVGMFL- 1606
            +Q   +   L   N +F  +F  E VLKLV+     +F   WN  D  +V+LS++G+ L 
Sbjct: 1475 NQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE 1534

Query: 1607 -AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1665
              E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL  L+
Sbjct: 1535 EIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1594

Query: 1666 MFIYAIFGMSNFAYV-----KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1720
             FIYA  G+  F  +         G+     FE FG + + LFQ++T   W+G++   L 
Sbjct: 1595 FFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR 1654

Query: 1721 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1780
                DC  D     SS++       V   +FVS+++ +  V++N+ +AV++++   + +E
Sbjct: 1655 ----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKE 1704

Query: 1781 SAEPLSEDDFEMFYEVWEKFDP 1802
            + E  +E D E+  E+     P
Sbjct: 1705 AQED-AEMDAELELEMAHGLGP 1725



 Score =  151 bits (381), Expect = 7e-36
 Identities = 115/432 (26%), Positives = 201/432 (46%), Gaps = 48/432 (11%)

Query: 616  RHGERRNSNVSQASMSSRMV--PGLPANGK---------------MHSTVDCNGVVSLVG 658
            R  +RR   + QA  S R    P  PA  K                HS +D      +  
Sbjct: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQP 506

Query: 659  GPSALTSPTGQLP---------PEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIA 709
             P+ L S     P         P G  +    ++   S      E   D  G + +   A
Sbjct: 507  IPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGA 566

Query: 710  SILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITIC 769
            S      EE EE                 +W C D W + +  +  IV   + +  I + 
Sbjct: 567  SSELGKEEEEEEQADGA------------VWLCGDVWRETRAKLRGIVDSKYFNRGIMMA 614

Query: 770  IVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDG 829
            I++NT+ M +EH+   E+ +++L + N+VFT +F  EM+LK+ A   + Y +  +NIFD 
Sbjct: 615  ILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDS 674

Query: 830  IIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 889
            IIV +S+ E+      GLSVLR+FRLLRV KL +  P L   + ++  ++  +    ++L
Sbjct: 675  IIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLL 734

Query: 890  AIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RWHMNDFFHSFLIVFRVLCGE-WIET 947
             + +FIF+++GM +FG  +     + +   T+P R + +    + + VF++L  E W   
Sbjct: 735  MLFIFIFSILGMHIFGCKFS---LRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVV 791

Query: 948  MWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSD---NLAATDDDNEMNNL 1004
            +++ M  +      + F+ +M  GN V+ NL +A+L+  F ++   N + +D+D   +N+
Sbjct: 792  LYNGM-ASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNI 850

Query: 1005 QIAVGRMQKGID 1016
            +    ++Q+G+D
Sbjct: 851  E-EFDKLQEGLD 861



 Score =  130 bits (327), Expect = 1e-29
 Identities = 107/411 (26%), Positives = 186/411 (45%), Gaps = 53/411 (12%)

Query: 70  PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129
           P  + EPL+  DP+  +                 A  A + L      R   IK++ +  
Sbjct: 35  PPGLEEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNPW 80

Query: 130 FSMLIMCTILTNCVFMTLSNP-------PDWTKNVEYTFTGIYTF---ESLIKILARGFC 179
           F  + M  IL NCV + +  P        D  K ++     I+ F   E ++K++A G  
Sbjct: 81  FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNV--SALRTFRVLRALKTISVIPGLKTIV 237
            +   +L D WN LDF +++   V   +DL N+  SA+RT RVLR LK I+ +P ++ +V
Sbjct: 141 GKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILV 199

Query: 238 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-----------LQWPPSDSA 286
             L+ ++  L +V++L  F   +F +IG+QL+ G LRN+C           +  PP    
Sbjct: 200 NLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQP 259

Query: 287 FETNTTSYFNGTMDSNGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDA 343
            E +   +       NG      +     +     +  D  +    G++D  L  +G   
Sbjct: 260 EEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQD--LNASGLCV 317

Query: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403
                  +C     NP+ G  +FD   +A++ +F+++T + W  +    + A      I+
Sbjct: 318 NWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIY 377

Query: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKK 454
           F+L+I +GSF+++NL L V+A  +          +E K+ E + MLEQ ++
Sbjct: 378 FILLIIVGSFFMINLCLVVIATQF----------SETKQREHRLMLEQRQR 418



 Score =  109 bits (273), Expect = 2e-23
 Identities = 76/271 (28%), Positives = 133/271 (49%), Gaps = 31/271 (11%)

Query: 752  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 811
            L++ +    ++D+ IT  I LN + M++EHY       + L   N +FT +F  E VLK+
Sbjct: 1444 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKL 1503

Query: 812  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE----------GLSVLRSFRLLRVFKL 861
            +A     +F++ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 1504 VAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKL 1563

Query: 862  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 921
             K    +  L+  +  ++  +GNL L+  ++ FI+A +G++LFGK     VC   + C  
Sbjct: 1564 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK----LVCNDENPCEG 1619

Query: 922  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVAGQTMCL--------IVFML 966
               H    +F  +FL +F+V  G+ W     +T+ DC     +  CL        + F+ 
Sbjct: 1620 MSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVS 1677

Query: 967  VMVIGNLVVLNLFLALLLSSFSSDNLAATDD 997
             ++    V++N+ +A+L+      N  A +D
Sbjct: 1678 FVLTAQFVLINVVVAVLMKHLDDSNKEAQED 1708



 Score =  107 bits (266), Expect = 2e-22
 Identities = 75/291 (25%), Positives = 135/291 (46%), Gaps = 38/291 (13%)

Query: 1511 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1568
            P N+F+ +    +  ++FD  ++  I LN +T+ +E    + G    + L+  N +F  +
Sbjct: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1179

Query: 1569 FTGEFVLKLVSLRHY-----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1623
            F GE  LK+VSL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1180 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1239

Query: 1624 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1677
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1240 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1299

Query: 1678 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1723
                                  +   +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1300 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1359

Query: 1724 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1774
             D  P T H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1360 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1399



 Score =  100 bits (250), Expect = 1e-20
 Identities = 81/330 (24%), Positives = 149/330 (45%), Gaps = 46/330 (13%)

Query: 1189 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1248
            G +W   R     IV+  +F   I+  IL+++ ++  E  + EQ + +  +LE  + VFT
Sbjct: 588  GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFT 645

Query: 1249 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1308
             +F LEM+LK  A+G   Y  N +   D +IV +S+  +V  A      G +  LRT R 
Sbjct: 646  SMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGLSVLRTFRL 700

Query: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
            LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  KF    ++ 
Sbjct: 701  LRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF----SLR 756

Query: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
            T     + D                   + NFD++    + + Q+ T + W  ++Y  + 
Sbjct: 757  TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 797

Query: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ---KKKFGGQDIFM 1485
            S           + +  LYFV  + FG++   NL + ++++ F  +    + +  +D   
Sbjct: 798  S----------TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSS 847

Query: 1486 T--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1513
            +  EE  K    +   G  K   PIP   N
Sbjct: 848  SNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 876



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 90/373 (24%), Positives = 161/373 (43%), Gaps = 75/373 (20%)

Query: 107  ALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE-------- 158
            ++Y+ +P N  R +   I+ H LF  +++  I  NC+ + L  P     + E        
Sbjct: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173

Query: 159  YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--------- 209
            Y FT I+  E  +K+++ G    +  +LR  WN LD  ++ ++ +   V L         
Sbjct: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233

Query: 210  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293

Query: 270  MGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLD 329
             G   + CL         +T   +  +  M +N  +V+     +N+ D +G       + 
Sbjct: 1294 KGKFYH-CL-------GVDTRNITNRSDCMAANYRWVH---HKYNF-DNLGQALMSLFVL 1341

Query: 330  GQKDPL--LCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWEN 387
              KD    +  NG DA    +  +      NP           W  L             
Sbjct: 1342 ASKDGWVNIMYNGLDAVAVDQQPV---TNHNP-----------WMLL------------- 1374

Query: 388  LYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQ 447
                        Y I F+L++   SF+++N+ + VV   + +  Q   +EAE+     ++
Sbjct: 1375 ------------YFISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEK 1417

Query: 448  MLEQLKKQQEEAQ 460
             L +L+K++ +AQ
Sbjct: 1418 RLRRLEKKRRKAQ 1430



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 71/274 (25%), Positives = 128/274 (46%), Gaps = 39/274 (14%)

Query: 752  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMV 808
            L   I+     D  +   I LN + +A+E  P  E  S+    LTV N +FT IF  EM 
Sbjct: 1127 LCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTAIFVGEMT 1185

Query: 809  LKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLL 856
            LK++++  Y+    Y +  WN+ DG +V +S++++ +S            L VLR  R L
Sbjct: 1186 LKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTL 1245

Query: 857  RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV---- 912
            R  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF   +  C+    
Sbjct: 1246 RPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDT 1305

Query: 913  --CKINDDCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG------ 956
                   DC     RW  H  +F      L+   VL  +  W+  M++ ++         
Sbjct: 1306 RNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1365

Query: 957  ---QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 987
                   L+ F+  ++I +  VLN+F+ +++ +F
Sbjct: 1366 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1399



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 58/170 (34%), Positives = 93/170 (54%), Gaps = 11/170 (6%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFI 1252
            R  C  +V + WFE   + +ILL+   L       +        K +  + D +F + F 
Sbjct: 69   RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FA 127

Query: 1253 LEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1309
            +EM+LK VA   +G + Y  + W  LDF IV   +  +V  +L    +  + ++RT+R L
Sbjct: 128  MEMVLKMVALGIFGKKCYLGDTWNRLDFFIV---MAGMVEYSLDLQNIN-LSAIRTVRVL 183

Query: 1310 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359
            RPL+A++R   MR++VN L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 184  RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/283 (25%), Positives = 135/283 (47%), Gaps = 35/283 (12%)

Query: 1523 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1582
            V  + F+  IM+ I +N V+M +E  +Q + +T +L   N+VF  +F  E +LKL +   
Sbjct: 602  VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 661

Query: 1583 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1641
            + Y    +NIFD ++VI+SI      E++ +   +     V+R  R+ R+L+L++    +
Sbjct: 662  FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 713

Query: 1642 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG--IDDMFNFETFG 1696
            R  L  LM ++  +    +LL L +FI++I GM  F     ++ + G  + D  NF++  
Sbjct: 714  RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 773

Query: 1697 NSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYII 1756
             +++ +FQI T   W+ +L   + S  P                         +FV+ + 
Sbjct: 774  WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 812

Query: 1757 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEK 1799
                V+ N+ +A+++E F    + +     ED      E ++K
Sbjct: 813  FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 855



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)

Query: 1398 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1457
            +NFDN+G  ++ + QV T +GW++IMY  +D+           + Y ++YF++ II GSF
Sbjct: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSF 387

Query: 1458 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1495
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 46/148 (31%), Positives = 83/148 (56%), Gaps = 13/148 (8%)

Query: 130 FSMLIMCTILTNCVFMTLSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 183
           F+  IM  IL N V M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662

Query: 184 TFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
            +LR+P+N  D S+IV+  + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 663 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 721

Query: 242 QSVKKLSDVMILTVFCLSVFALIGLQLF 269
           +++  ++   +L +  + +F+++G+ +F
Sbjct: 722 KTMDNVATFCMLLMLFIFIFSILGMHIF 749



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 49/186 (26%), Positives = 96/186 (51%), Gaps = 19/186 (10%)

Query: 756 IVMDPFVDLAITICIVLNTLFMAMEHYP------MTEQFSSVLTVGNLVFTGIFTAEMVL 809
           +V +P+ +    + I+LN + + M + P      ++++   +    + +F   F  EMVL
Sbjct: 75  MVCNPWFECVSMLVILLNCVTLGM-YQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEMVL 132

Query: 810 KIIAMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKS 864
           K++A+  +    Y  + WN  D  IV   ++E  L L N+  LS +R+ R+LR  K    
Sbjct: 133 KMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINR 191

Query: 865 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKINDDC 919
            P++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+      + + E    I  D 
Sbjct: 192 VPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDV 251

Query: 920 TLPRWH 925
            LP ++
Sbjct: 252 ALPPYY 257



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 15/159 (9%)

Query: 1528 FDISIMILICLNMVTM-MVETDDQGKYMT---LVLSRINLVFIVLFTGEFVLKLVSL--- 1580
            F+   M++I LN VT+ M +  D    ++    +L   +    + F  E VLK+V+L   
Sbjct: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 1581 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1639
             +  Y    WN  DF +V+  +V   L        +       IR  R+ R L+ I    
Sbjct: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193

Query: 1640 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1678
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)

Query: 365 SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
           +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827

Query: 425 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 457
             ++ +  A    +++ ++     +E+  K QE
Sbjct: 828 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 858



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 26/95 (27%), Positives = 49/95 (51%), Gaps = 12/95 (12%)

Query: 363  YTSFDTFSWAFLSLFRLMTQDYWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 411
            + +F+ F  AFL+LF++ T D W  + + TLR           +      ++FV  +   
Sbjct: 1623 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1682

Query: 412  SFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQ 446
             F L+N+++AV+    ++ N+   E+AE  +AE +
Sbjct: 1683 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE 1716



 Score = 35.8 bits (81), Expect = 0.43
 Identities = 17/59 (28%), Positives = 39/59 (66%), Gaps = 2/59 (3%)

Query: 931 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 988
           ++++++F+V+  E W+E M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402


>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform a [Homo sapiens]
          Length = 2223

 Score =  343 bits (881), Expect = 7e-94
 Identities = 212/622 (34%), Positives = 344/622 (55%), Gaps = 36/622 (5%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1255
            R  C +I+ H  F+  ++  I L+   +A E   IE   T +  L  ++ +FT IF+ EM
Sbjct: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219

Query: 1256 LLKWVA----YGFQTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1308
             LK V+    +G Q Y  ++W  LD  +V VS++ +V   A+A G   LG ++ LR LR 
Sbjct: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279

Query: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYHC+ + 
Sbjct: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVD 1339

Query: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
            T N      + N SDC A     RW + K NFDN+G   ++L  +A+  GW++IMY  +D
Sbjct: 1340 TRN------ITNRSDCMA--ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLD 1391

Query: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1488
            +  V  QPV   N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++    EE
Sbjct: 1392 AVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1451

Query: 1489 QKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD 1548
              K    ++K   K  + P        + ++    T    DI I  +ICLN+VTM +E  
Sbjct: 1452 --KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHY 1509

Query: 1549 DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL-RHYYFTIGWNIFDFVVVILSIVGMFL- 1606
            +Q   +   L   N +F  +F  E VLKLV+     +F   WN  D  +V+LS++G+ L 
Sbjct: 1510 NQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE 1569

Query: 1607 -AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1665
              E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL  L+
Sbjct: 1570 EIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1629

Query: 1666 MFIYAIFGMSNFAYV-----KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1720
             FIYA  G+  F  +         G+     FE FG + + LFQ++T   W+G++   L 
Sbjct: 1630 FFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR 1689

Query: 1721 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1780
                DC  D     SS++       V   +FVS+++ +  V++N+ +AV++++   + +E
Sbjct: 1690 ----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKE 1739

Query: 1781 SAEPLSEDDFEMFYEVWEKFDP 1802
            + E  +E D E+  E+     P
Sbjct: 1740 AQED-AEMDAELELEMAHGLGP 1760



 Score =  151 bits (382), Expect = 5e-36
 Identities = 112/428 (26%), Positives = 201/428 (46%), Gaps = 43/428 (10%)

Query: 615  HRHGERRNSNVSQASMSSRMV--------PGLPANGK----MHSTVDCNGVVSLVGGPSA 662
            H HG+ +        + SR          PG   +G+     HS +D      +   P+ 
Sbjct: 486  HYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQPIPAT 545

Query: 663  LTSPTGQLP---------PEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILT 713
            L S     P         P G  +    ++   S      E   D  G + +   AS   
Sbjct: 546  LASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSEL 605

Query: 714  NTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLN 773
               EE EE                 +W C D W + +  +  IV   + +  I + I++N
Sbjct: 606  GKEEEEEEQADGA------------VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVN 653

Query: 774  TLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVS 833
            T+ M +EH+   E+ +++L + N+VFT +F  EM+LK+ A   + Y +  +NIFD IIV 
Sbjct: 654  TVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVI 713

Query: 834  LSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIV 893
            +S+ E+      GLSVLR+FRLLRV KL +  P L   + ++  ++  +    ++L + +
Sbjct: 714  ISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFI 773

Query: 894  FIFAVVGMQLFGKSYKECVCKINDDCTLP-RWHMNDFFHSFLIVFRVLCGE-WIETMWDC 951
            FIF+++GM +FG  +     + +   T+P R + +    + + VF++L  E W   +++ 
Sbjct: 774  FIFSILGMHIFGCKFS---LRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNG 830

Query: 952  MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAV 1008
            M  +      + F+ +M  GN V+ NL +A+L+  F ++   N + +D+D   +N++   
Sbjct: 831  M-ASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EF 888

Query: 1009 GRMQKGID 1016
             ++Q+G+D
Sbjct: 889  DKLQEGLD 896



 Score =  130 bits (327), Expect = 1e-29
 Identities = 107/411 (26%), Positives = 186/411 (45%), Gaps = 53/411 (12%)

Query: 70  PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129
           P  + EPL+  DP+  +                 A  A + L      R   IK++ +  
Sbjct: 35  PPGLEEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNPW 80

Query: 130 FSMLIMCTILTNCVFMTLSNP-------PDWTKNVEYTFTGIYTF---ESLIKILARGFC 179
           F  + M  IL NCV + +  P        D  K ++     I+ F   E ++K++A G  
Sbjct: 81  FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNV--SALRTFRVLRALKTISVIPGLKTIV 237
            +   +L D WN LDF +++   V   +DL N+  SA+RT RVLR LK I+ +P ++ +V
Sbjct: 141 GKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILV 199

Query: 238 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-----------LQWPPSDSA 286
             L+ ++  L +V++L  F   +F +IG+QL+ G LRN+C           +  PP    
Sbjct: 200 NLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQP 259

Query: 287 FETNTTSYFNGTMDSNGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDA 343
            E +   +       NG      +     +     +  D  +    G++D  L  +G   
Sbjct: 260 EEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQD--LNASGLCV 317

Query: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403
                  +C     NP+ G  +FD   +A++ +F+++T + W  +    + A      I+
Sbjct: 318 NWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIY 377

Query: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKK 454
           F+L+I +GSF+++NL L V+A  +          +E K+ E + MLEQ ++
Sbjct: 378 FILLIIVGSFFMINLCLVVIATQF----------SETKQREHRLMLEQRQR 418



 Score =  109 bits (273), Expect = 2e-23
 Identities = 76/271 (28%), Positives = 133/271 (49%), Gaps = 31/271 (11%)

Query: 752  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 811
            L++ +    ++D+ IT  I LN + M++EHY       + L   N +FT +F  E VLK+
Sbjct: 1479 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKL 1538

Query: 812  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE----------GLSVLRSFRLLRVFKL 861
            +A     +F++ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 1539 VAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKL 1598

Query: 862  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 921
             K    +  L+  +  ++  +GNL L+  ++ FI+A +G++LFGK     VC   + C  
Sbjct: 1599 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK----LVCNDENPCEG 1654

Query: 922  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVAGQTMCL--------IVFML 966
               H    +F  +FL +F+V  G+ W     +T+ DC     +  CL        + F+ 
Sbjct: 1655 MSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVS 1712

Query: 967  VMVIGNLVVLNLFLALLLSSFSSDNLAATDD 997
             ++    V++N+ +A+L+      N  A +D
Sbjct: 1713 FVLTAQFVLINVVVAVLMKHLDDSNKEAQED 1743



 Score =  107 bits (266), Expect = 2e-22
 Identities = 75/291 (25%), Positives = 135/291 (46%), Gaps = 38/291 (13%)

Query: 1511 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1568
            P N+F+ +    +  ++FD  ++  I LN +T+ +E    + G    + L+  N +F  +
Sbjct: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1214

Query: 1569 FTGEFVLKLVSLRHY-----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1623
            F GE  LK+VSL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1215 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1274

Query: 1624 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1677
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1275 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1334

Query: 1678 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1723
                                  +   +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1335 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1394

Query: 1724 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1774
             D  P T H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1395 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1434



 Score =  100 bits (250), Expect = 1e-20
 Identities = 81/330 (24%), Positives = 149/330 (45%), Gaps = 46/330 (13%)

Query: 1189 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1248
            G +W   R     IV+  +F   I+  IL+++ ++  E  + EQ + +  +LE  + VFT
Sbjct: 623  GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFT 680

Query: 1249 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1308
             +F LEM+LK  A+G   Y  N +   D +IV +S+  +V  A      G +  LRT R 
Sbjct: 681  SMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGLSVLRTFRL 735

Query: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
            LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  KF    ++ 
Sbjct: 736  LRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF----SLR 791

Query: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
            T     + D                   + NFD++    + + Q+ T + W  ++Y  + 
Sbjct: 792  TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 832

Query: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ---KKKFGGQDIFM 1485
            S           + +  LYFV  + FG++   NL + ++++ F  +    + +  +D   
Sbjct: 833  S----------TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSS 882

Query: 1486 T--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1513
            +  EE  K    +   G  K   PIP   N
Sbjct: 883  SNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 911



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 90/373 (24%), Positives = 161/373 (43%), Gaps = 75/373 (20%)

Query: 107  ALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE-------- 158
            ++Y+ +P N  R +   I+ H LF  +++  I  NC+ + L  P     + E        
Sbjct: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208

Query: 159  YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--------- 209
            Y FT I+  E  +K+++ G    +  +LR  WN LD  ++ ++ +   V L         
Sbjct: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268

Query: 210  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328

Query: 270  MGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLD 329
             G   + CL         +T   +  +  M +N  +V+     +N+ D +G       + 
Sbjct: 1329 KGKFYH-CL-------GVDTRNITNRSDCMAANYRWVH---HKYNF-DNLGQALMSLFVL 1376

Query: 330  GQKDPL--LCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWEN 387
              KD    +  NG DA    +  +      NP           W  L             
Sbjct: 1377 ASKDGWVNIMYNGLDAVAVDQQPV---TNHNP-----------WMLL------------- 1409

Query: 388  LYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQ 447
                        Y I F+L++   SF+++N+ + VV   + +  Q   +EAE+     ++
Sbjct: 1410 ------------YFISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEK 1452

Query: 448  MLEQLKKQQEEAQ 460
             L +L+K++ +AQ
Sbjct: 1453 RLRRLEKKRRKAQ 1465



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 71/274 (25%), Positives = 128/274 (46%), Gaps = 39/274 (14%)

Query: 752  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMV 808
            L   I+     D  +   I LN + +A+E  P  E  S+    LTV N +FT IF  EM 
Sbjct: 1162 LCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTAIFVGEMT 1220

Query: 809  LKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLL 856
            LK++++  Y+    Y +  WN+ DG +V +S++++ +S            L VLR  R L
Sbjct: 1221 LKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTL 1280

Query: 857  RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV---- 912
            R  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF   +  C+    
Sbjct: 1281 RPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDT 1340

Query: 913  --CKINDDCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG------ 956
                   DC     RW  H  +F      L+   VL  +  W+  M++ ++         
Sbjct: 1341 RNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1400

Query: 957  ---QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 987
                   L+ F+  ++I +  VLN+F+ +++ +F
Sbjct: 1401 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1434



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 58/170 (34%), Positives = 93/170 (54%), Gaps = 11/170 (6%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFI 1252
            R  C  +V + WFE   + +ILL+   L       +        K +  + D +F + F 
Sbjct: 69   RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FA 127

Query: 1253 LEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1309
            +EM+LK VA   +G + Y  + W  LDF IV   +  +V  +L    +  + ++RT+R L
Sbjct: 128  MEMVLKMVALGIFGKKCYLGDTWNRLDFFIV---MAGMVEYSLDLQNIN-LSAIRTVRVL 183

Query: 1310 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359
            RPL+A++R   MR++VN L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 184  RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 72/283 (25%), Positives = 135/283 (47%), Gaps = 35/283 (12%)

Query: 1523 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1582
            V  + F+  IM+ I +N V+M +E  +Q + +T +L   N+VF  +F  E +LKL +   
Sbjct: 637  VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 696

Query: 1583 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1641
            + Y    +NIFD ++VI+SI      E++ +   +     V+R  R+ R+L+L++    +
Sbjct: 697  FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 748

Query: 1642 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG--IDDMFNFETFG 1696
            R  L  LM ++  +    +LL L +FI++I GM  F     ++ + G  + D  NF++  
Sbjct: 749  RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 808

Query: 1697 NSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYII 1756
             +++ +FQI T   W+ +L   + S  P                         +FV+ + 
Sbjct: 809  WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 847

Query: 1757 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEK 1799
                V+ N+ +A+++E F    + +     ED      E ++K
Sbjct: 848  FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 890



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)

Query: 1398 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1457
            +NFDN+G  ++ + QV T +GW++IMY  +D+           + Y ++YF++ II GSF
Sbjct: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSF 387

Query: 1458 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1495
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 46/148 (31%), Positives = 83/148 (56%), Gaps = 13/148 (8%)

Query: 130 FSMLIMCTILTNCVFMTLSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 183
           F+  IM  IL N V M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 642 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 697

Query: 184 TFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
            +LR+P+N  D S+IV+  + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 698 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 756

Query: 242 QSVKKLSDVMILTVFCLSVFALIGLQLF 269
           +++  ++   +L +  + +F+++G+ +F
Sbjct: 757 KTMDNVATFCMLLMLFIFIFSILGMHIF 784



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 49/186 (26%), Positives = 96/186 (51%), Gaps = 19/186 (10%)

Query: 756 IVMDPFVDLAITICIVLNTLFMAMEHYP------MTEQFSSVLTVGNLVFTGIFTAEMVL 809
           +V +P+ +    + I+LN + + M + P      ++++   +    + +F   F  EMVL
Sbjct: 75  MVCNPWFECVSMLVILLNCVTLGM-YQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEMVL 132

Query: 810 KIIAMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKS 864
           K++A+  +    Y  + WN  D  IV   ++E  L L N+  LS +R+ R+LR  K    
Sbjct: 133 KMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINR 191

Query: 865 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKINDDC 919
            P++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+      + + E    I  D 
Sbjct: 192 VPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDV 251

Query: 920 TLPRWH 925
            LP ++
Sbjct: 252 ALPPYY 257



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 15/159 (9%)

Query: 1528 FDISIMILICLNMVTM-MVETDDQGKYMT---LVLSRINLVFIVLFTGEFVLKLVSL--- 1580
            F+   M++I LN VT+ M +  D    ++    +L   +    + F  E VLK+V+L   
Sbjct: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 1581 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1639
             +  Y    WN  DF +V+  +V   L        +       IR  R+ R L+ I    
Sbjct: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193

Query: 1640 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1678
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)

Query: 365 SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
           +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862

Query: 425 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 457
             ++ +  A    +++ ++     +E+  K QE
Sbjct: 863 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 893



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 26/95 (27%), Positives = 49/95 (51%), Gaps = 12/95 (12%)

Query: 363  YTSFDTFSWAFLSLFRLMTQDYWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 411
            + +F+ F  AFL+LF++ T D W  + + TLR           +      ++FV  +   
Sbjct: 1658 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1717

Query: 412  SFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQ 446
             F L+N+++AV+    ++ N+   E+AE  +AE +
Sbjct: 1718 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE 1751



 Score = 35.8 bits (81), Expect = 0.43
 Identities = 17/59 (28%), Positives = 39/59 (66%), Gaps = 2/59 (3%)

Query: 931 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 988
           ++++++F+V+  E W+E M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score =  338 bits (866), Expect = 4e-92
 Identities = 206/651 (31%), Positives = 359/651 (55%), Gaps = 41/651 (6%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1255
            R +C  ++ H  F+  ++  I L+   +A E   I+   T +  L  ++ +FT IF+ EM
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343

Query: 1256 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1308
            ++K VA G       Y  ++W  LD L+V VSLV +V   A+A G   LG ++ LR LR 
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403

Query: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFY+C    
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463

Query: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
            T N      ++  + C+A     RW   K NFDN+G   ++L  +++  GW++IMY  +D
Sbjct: 1464 TRN------ISTKAQCRA--AHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLD 1515

Query: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1488
            +  V  QPV   N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++    EE
Sbjct: 1516 AVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1575

Query: 1489 QKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD 1548
              K    +++   K  ++P     +  +  +    T    D+ I  +IC+N++TM +E  
Sbjct: 1576 --KRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHY 1633

Query: 1549 DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSIVGMFL- 1606
            +Q K +   L   N VF ++F  E  LKLV+     +F   WN  D  +V+LS++G+ L 
Sbjct: 1634 NQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLE 1693

Query: 1607 -AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1665
              EM     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL  L+
Sbjct: 1694 EIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1753

Query: 1666 MFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1720
             FIYA  G+  F  ++        G+     F  FG + + LF+++T   W+G++   L 
Sbjct: 1754 FFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLR 1813

Query: 1721 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1780
                +C  +  H  S +      P++   +FV++++++  V+VN+ +AV++++   + +E
Sbjct: 1814 ----ECSREDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKE 1863

Query: 1781 SAEPLSEDDFEMFYEVWEKFDPDATQFIEFSK---LSDFAAALDPPLLIAK 1828
            + E  +E D E+  E+ +   P + + ++  +     +   A D P L+A+
Sbjct: 1864 ARED-AELDAEIELEMAQ--GPGSARRVDADRPPLPQESPGARDAPNLVAR 1911



 Score =  141 bits (355), Expect = 7e-33
 Identities = 83/258 (32%), Positives = 145/258 (56%), Gaps = 9/258 (3%)

Query: 746  WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 805
            W+     +  IV   +    I + I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838

Query: 806  EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 865
            EM+LK++A  P  Y +  +NIFDGIIV +S+ E+      GLSVLR+FRLLRV KL +  
Sbjct: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898

Query: 866  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 924
            P L   + ++  ++  +     +L + +FIF+++GM LFG  +     K +   T+P R 
Sbjct: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS---LKTDTGDTVPDRK 955

Query: 925  HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 983
            + +    + + VF++L  E W   +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014

Query: 984  LSSFSSD---NLAATDDD 998
            +  F ++   N + TD+D
Sbjct: 1015 VEGFQAEGDANRSDTDED 1032



 Score =  132 bits (332), Expect = 3e-30
 Identities = 109/470 (23%), Positives = 204/470 (43%), Gaps = 95/470 (20%)

Query: 104 ATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTK------NV 157
           A +  + L      R   ++++ +  F  + M  I+ NCV + +  P +  +      N+
Sbjct: 76  AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135

Query: 158 EYTFTGI----YTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS 213
              F       +  E +IK++A G   +   +L D WN LDF ++V   +   +D  NVS
Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGLFGQK-CYLGDTWNRLDFFIVVAGMMEYSLDGHNVS 194

Query: 214 --ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
             A+RT RVLR L+ I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G
Sbjct: 195 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254

Query: 272 NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331
            LRN+C      DSAF  N          +N TF+                 ++   +G+
Sbjct: 255 LLRNRCF----LDSAFVRN----------NNLTFLR---------------PYYQTEEGE 285

Query: 332 KDPLLCGNGSDAGQ---------------CPEGY-------------------------- 350
           ++P +C +  D G                C  G+                          
Sbjct: 286 ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYN 345

Query: 351 ICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFL 410
           +C     NP+ G  +FD   +A++++F+++T + W ++    + A      I+F+L+I +
Sbjct: 346 VCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIV 405

Query: 411 GSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASR 470
           GSF+++NL L V+A  +          +E K+ E Q M EQ  +       +A+ S    
Sbjct: 406 GSFFMINLCLVVIATQF----------SETKQRESQLMREQRARHLSNDSTLASFSEPGS 455

Query: 471 DFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGER 520
            +  +  L  +     +  + S +    W++R +K+     ++G   G R
Sbjct: 456 CYEEL--LKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHR 503



 Score =  113 bits (282), Expect = 2e-24
 Identities = 143/670 (21%), Positives = 277/670 (41%), Gaps = 114/670 (17%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
            +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015

Query: 425  MAYEEQNQATLEEAEQKEAE--FQQMLEQLKK-QQEEAQAVAAASAASRDFSGIGGLGEL 481
              ++ +  A   + ++ +    F++   +L++ Q  E +  + A   +    G G L   
Sbjct: 1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPP 1075

Query: 482  LESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSM 541
            L   + A+ + +                            S P  ++  S+  S    S 
Sbjct: 1076 LIMCTAATPMPTPK--------------------------SSPFLDAAPSLPDSRRGSSS 1109

Query: 542  DGNRLTSDKKFCSPHQSLLSIRGSLFSPRR--NSKTSIFSFRGRAKDVGSENDFADDEHS 599
             G+    D+K   P  SL S   + + P    +S+ S +S  GRA  +       +    
Sbjct: 1110 SGDPPLGDQK---PPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGE---- 1162

Query: 600  TFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANG-KMHSTVDCNGVVSLVG 658
                    R+SL      GE + S   +A    R  PG  A   +   ++D   +     
Sbjct: 1163 --------RESLL----SGEGKGSTDDEAE-DGRAAPGPRATPLRRAESLDPRPLRPAAL 1209

Query: 659  GPSALTSPTGQ---LPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNT 715
             P+      GQ   LP +           R+ S++     L+D S     + +  +L   
Sbjct: 1210 PPTKCRDRDGQVVALPSDFFL--------RIDSHREDAAELDDDSEDSCCLRLHKVLEPY 1261

Query: 716  MEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTL 775
              +   SR+      +   N F +   C            ++     D  + + I LN +
Sbjct: 1262 KPQWCRSREAWALYLFSPQNRFRV--SCQK----------VITHKMFDHVVLVFIFLNCV 1309

Query: 776  FMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMVLKIIAMD----PYYYFQEGWNIFD 828
             +A+E  P  +  S+    L+V N +FT IF AEM++K++A+      + Y Q  WN+ D
Sbjct: 1310 TIALER-PDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLD 1368

Query: 829  GIIVSLSLMEL--------GLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 880
            G++V +SL+++        G   +  L VLR  R LR  ++    P L ++++ + +S+ 
Sbjct: 1369 GLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLR 1428

Query: 881  ALGNLTLVLAIIVFIFAVVGMQLF-GKSY-----------KECVCKINDDCTLPRWHMND 928
             +GN+ L+      IF ++G+QLF GK Y            +  C+      + R +  D
Sbjct: 1429 PIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFD 1488

Query: 929  FFHSFLIVFRVLCGE--WIETMWDCMEVAG---------QTMCLIVFMLVMVIGNLVVLN 977
                 L+   VL  +  W+  M+D ++  G             L+ F+  ++I +  VLN
Sbjct: 1489 NLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLN 1548

Query: 978  LFLALLLSSF 987
            +F+ +++ +F
Sbjct: 1549 MFVGVVVENF 1558



 Score =  109 bits (272), Expect = 3e-23
 Identities = 75/260 (28%), Positives = 128/260 (49%), Gaps = 27/260 (10%)

Query: 761  FVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYF 820
            ++DL IT  I +N + M+MEHY   +     L   N VFT +F  E  LK++A     +F
Sbjct: 1612 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1671

Query: 821  QEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKLAKSWPTLNM 870
            ++ WN  D  IV LSLM + L  +E           + ++R  R+ RV KL K    +  
Sbjct: 1672 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1731

Query: 871  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWH--MND 928
            L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      C  ++ C     H   ++
Sbjct: 1732 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGLSRHATFSN 1787

Query: 929  FFHSFLIVFRVLCGE-WIETMWDCMEVAGQ--TMCL--------IVFMLVMVIGNLVVLN 977
            F  +FL +FRV  G+ W   M D +    +    CL        + F+  +++   V++N
Sbjct: 1788 FGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1847

Query: 978  LFLALLLSSFSSDNLAATDD 997
            + +A+L+      N  A +D
Sbjct: 1848 VVVAVLMKHLEESNKEARED 1867



 Score =  106 bits (265), Expect = 2e-22
 Identities = 76/291 (26%), Positives = 138/291 (47%), Gaps = 38/291 (13%)

Query: 1511 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1568
            P N+F+      +T ++FD  +++ I LN VT+ +E    D G    + LS  N +F  +
Sbjct: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338

Query: 1569 FTGEFVLKLVSL-----RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1623
            F  E ++K+V+L      H Y    WN+ D ++V++S+V + +A           + RV+
Sbjct: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398

Query: 1624 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1677
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458

Query: 1678 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1723
                                  +   +NF+  G +++ LF +++  GW  ++   L++  
Sbjct: 1459 CEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518

Query: 1724 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1774
             D  P   H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1519 VDQQPVQNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 79/280 (28%), Positives = 128/280 (45%), Gaps = 28/280 (10%)

Query: 9    PGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDI 68
            PGP +  L   ESL   + R     A  P K +D D +    P SD        F+  D 
Sbjct: 1186 PGPRATPLRRAESL---DPRPLRPAALPPTKCRDRDGQVVALP-SDF-------FLRIDS 1234

Query: 69   PPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHS 128
              E  +E  +D +     +   ++        R     ALY+ +P N  R    K++ H 
Sbjct: 1235 HREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHK 1294

Query: 129  LFSMLIMCTILTNCVFMTLSNP---PDWTKNV-----EYTFTGIYTFESLIKILARGFCL 180
            +F  +++  I  NCV + L  P   P  T+ V      Y FT I+  E ++K++A G   
Sbjct: 1295 MFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLS 1354

Query: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGNVSALRTFRVLRALKTISVIP 231
             +  +L+  WN LD  +++++ V   V          LG +  LR  R LR L+ IS  P
Sbjct: 1355 GEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAP 1414

Query: 232  GLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            GLK +V  LI S++ + +++++      +F ++G+QLF G
Sbjct: 1415 GLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKG 1454



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 74/286 (25%), Positives = 133/286 (46%), Gaps = 40/286 (13%)

Query: 1189 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1248
            G++W         IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT
Sbjct: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833

Query: 1249 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1308
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V  A      G +  LRT R 
Sbjct: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA-----DGGLSVLRTFRL 888

Query: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
            LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  KF    ++ 
Sbjct: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKF----SLK 944

Query: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
            T     + D                   + NFD++    + + Q+ T + W  ++Y  + 
Sbjct: 945  TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 985

Query: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1474
            S           + +  LYFV  + FG++   NL + ++++ F  +
Sbjct: 986  S----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021



 Score = 91.3 bits (225), Expect = 9e-18
 Identities = 61/174 (35%), Positives = 93/174 (53%), Gaps = 19/174 (10%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1251
            R  C  +V + WFE   + +I+L+   L      ED+     +    +LE  D      F
Sbjct: 90   RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147

Query: 1252 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELG---AIKSLRT 1305
             +EM++K VA   +G + Y  + W  LDF IV       VA  + YS  G   ++ ++RT
Sbjct: 148  AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAIRT 200

Query: 1306 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 201  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 73/290 (25%), Positives = 131/290 (45%), Gaps = 41/290 (14%)

Query: 1515 FQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFV 1574
            F G +   V  + F   IM+ I +N ++M VE  +Q + +T  L   N+VF  +F  E +
Sbjct: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841

Query: 1575 LKLVSLRHY-YFTIGWNIFDFVVVILS---IVGMFLAEMIEKYFVSPTLFRVIRLARIGR 1630
            LKL++     Y    +NIFD ++V++S   IVG            +     V+R  R+ R
Sbjct: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQ-----------ADGGLSVLRTFRLLR 890

Query: 1631 ILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG-- 1685
            +L+L++    +R  L  L+ ++  +     LL L +FI++I GM  F     +K + G  
Sbjct: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950

Query: 1686 IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPS 1745
            + D  NF++   +++ +FQI T   W+ +L                       G     S
Sbjct: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSS 989

Query: 1746 VGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1795
                +FV+ +     V+ N+ +A+++E F    + +     ED   + +E
Sbjct: 990  WAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 41/132 (31%), Positives = 70/132 (53%), Gaps = 13/132 (9%)

Query: 1395 NVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIF 1454
            N  +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II 
Sbjct: 356  NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNFIYFILLIIV 405

Query: 1455 GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANK 1514
            GSFF +NL + VI   F++ K++   +   M E++ ++ +    L S            K
Sbjct: 406  GSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLK 462

Query: 1515 FQGMVFDFVTRQ 1526
            + G +F  V R+
Sbjct: 463  YVGHIFRKVKRR 474



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 48/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176
           +I+    FS  IM  IL N + M +     P + T  +E +   FT ++  E L+K+LA 
Sbjct: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847

Query: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G       ++R+P+N  D  +IV+  V E V    G +S LRTFR+LR LK +  +P L+
Sbjct: 848 G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++    L +  + +F+++G+ LF
Sbjct: 903 RQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 42/157 (26%), Positives = 80/157 (50%), Gaps = 8/157 (5%)

Query: 756 IVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 811
           +V +P+ +    + I+LN + + M    E      +  ++L   +      F  EMV+K+
Sbjct: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 812 IAMDPY---YYFQEGWNIFDGIIVSLSLMELGLSNVE-GLSVLRSFRLLRVFKLAKSWPT 867
           +A+  +    Y  + WN  D  IV   +ME  L      LS +R+ R+LR  +     P+
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215

Query: 868 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 904
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 44/198 (22%), Positives = 95/198 (47%), Gaps = 24/198 (12%)

Query: 115  NPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLS--NPP----DWTKNVEYTFTGIYTFE 168
            +P R+    +       + I   I  N + M++   N P    +  K   Y FT ++ FE
Sbjct: 1598 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFE 1657

Query: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA-----------LRT 217
            + +K++A GF      F +D WN LD ++++++ +   ++   +SA           +R 
Sbjct: 1658 AALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRV 1713

Query: 218  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC 277
             R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF    R +C
Sbjct: 1714 LRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFG---RLEC 1770

Query: 278  LQWPPSDSAFETNTTSYF 295
             +  P +      T S F
Sbjct: 1771 SEDNPCEGLSRHATFSNF 1788



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 48/159 (30%), Positives = 75/159 (47%), Gaps = 15/159 (9%)

Query: 1528 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHY 1583
            F+   M++I LN VT+ +    E  + G     +L   +      F  E V+K+V+L  +
Sbjct: 102  FEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLF 161

Query: 1584 ----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1639
                Y    WN  DF +V+  ++   L    + + VS      IR  R+ R LR I    
Sbjct: 162  GQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVS---LSAIRTVRVLRPLRAINRVP 214

Query: 1640 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1678
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 215  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 39/141 (27%), Positives = 65/141 (46%), Gaps = 19/141 (13%)

Query: 345  QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGK------ 398
            +C E   C    R     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1769 ECSEDNPCEGLSR-----HATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCL 1823

Query: 399  TYM-----IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAE---QKEAEFQQMLE 450
            +Y+     ++FV  + +  F LVN+++AV+    EE N+   E+AE   + E E  Q   
Sbjct: 1824 SYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQGPG 1883

Query: 451  QLKKQQEEAQAVAAASAASRD 471
              ++   +   +   S  +RD
Sbjct: 1884 SARRVDADRPPLPQESPGARD 1904



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 931 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 988
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 366 YAWIAIFQVITLEGWVDIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 423



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1691 NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFF 1750
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 360  NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA---------------------HSFYNFIY 398

Query: 1751 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1787
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 399  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 435


>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
            subunit isoform c [Homo sapiens]
          Length = 2137

 Score =  333 bits (855), Expect = 8e-91
 Identities = 243/823 (29%), Positives = 417/823 (50%), Gaps = 83/823 (10%)

Query: 1099 LTVTVPIAVGE-SDFENLNTEEFSSESELEE--------------SKEKLNATSSSEGS- 1142
            L V + IAV   +D E+LNT +     E E               +K ++N  ++S+   
Sbjct: 744  LNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKV 803

Query: 1143 TVDVVLPRE-------------GEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKG 1189
            T+D     +             GE+ E E E++ +  A      I +    +      +G
Sbjct: 804  TIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEG 863

Query: 1190 KIWWNLRKT------CYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYA 1243
              ++ L KT      C+ ++ H+ F   I+  I+LSS ALA ED  I       T+L Y 
Sbjct: 864  SAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDP-IRSHSFRNTILGYF 922

Query: 1244 DKVFTYIFILEMLLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGA 1299
            D  FT IF +E+LLK   +G       +  N +  LD L+V VSLVS     +  S +  
Sbjct: 923  DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSF---GIQSSAISV 979

Query: 1300 IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359
            +K LR LR LRPLRA++R +G++ VV  +  AI +I N+++V  +   +F+ +GV LF G
Sbjct: 980  VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG 1039

Query: 1360 KFYHCVNMTTGN---------MFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLAL 1410
            KFY C +    N         ++   DV++      + ++  W+N   NFDNV +  +AL
Sbjct: 1040 KFYRCTDEAKSNPEECRGLFILYKDGDVDS-----PVVRERIWQNSDFNFDNVLSAMMAL 1094

Query: 1411 LQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDN 1470
              V+TF+GW  ++Y A+DS    + P+Y   + + ++F+I+II  +FF +N+F+G +I  
Sbjct: 1095 FTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVT 1154

Query: 1471 FNQQ-KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PANKFQGMVFDFVTRQV 1527
            F +Q +K++   ++   + Q   Y A+K        +P+ R  P N +Q   +  V    
Sbjct: 1155 FQEQGEKEYKNCELDKNQRQCVEY-ALK-------ARPLRRYIPKNPYQYKFWYVVNSSP 1206

Query: 1528 FDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFT 1586
            F+  + +LI LN + + ++  +Q K     +  +N+VF  +FT E VLK+++ +   YF+
Sbjct: 1207 FEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFS 1266

Query: 1587 IGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1646
              WN FD ++VI SI+ + L+E       +       RL R+ R+++L+   +GIRTLL+
Sbjct: 1267 DAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLW 1326

Query: 1647 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV--KKEAGIDDMFNFETFGNSMICLFQ 1704
              + S  AL  + LL+ ++ FIYA+ GM  F  V  +    I+   NF+TF  +++ LF+
Sbjct: 1327 TFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFR 1386

Query: 1705 ITTSAGWDGLLAPILNSAPPDCDPDT-IHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVV 1763
              T   W  ++   L      CDP++  +PG      CG+ +  I +F+S+ ++   +++
Sbjct: 1387 CATGEAWQEIMLACLPGKL--CDPESDYNPGEEY--TCGS-NFAIVYFISFYMLCAFLII 1441

Query: 1764 NMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPP 1823
            N+++AVI++NF   T + +  L     + F  +W ++DP+A   I+   +      + PP
Sbjct: 1442 NLFVAVIMDNFDYLTRDWS-ILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPP 1500

Query: 1824 LLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAFTKRVL 1861
            L   K  P++V   +L+AM++P+ S   +     LFA  +  L
Sbjct: 1501 LGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTAL 1543



 Score =  150 bits (378), Expect = 2e-35
 Identities = 121/457 (26%), Positives = 207/457 (45%), Gaps = 98/457 (21%)

Query: 107 ALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNP-PDWTKN--------V 157
           AL+ L+  NP+R+  I I+    F + I+  I  NCV + +  P P+   N        V
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164

Query: 158 EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAY-------VTEFVDLG 210
           EY F  I+T E+ +KI+A G  L    ++R+ WN LDF ++++         +T+  + G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224

Query: 211 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 260
           N          V ALR FRVLR L+ +S +P L+ ++ ++I+++  L  + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284

Query: 261 FALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIG 320
           +A+IGL+LF+G +   C                                   F   D + 
Sbjct: 285 YAIIGLELFIGKMHKTCF----------------------------------FADSDIVA 310

Query: 321 DDSHFYVLDGQKDPLLCGNGSDAGQC-PEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRL 379
           ++          DP  C    +  QC   G  C      PN G T+FD F++A L++F+ 
Sbjct: 311 EE----------DPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360

Query: 380 MTQDYWEN-LYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAY-EEQNQATLEE 437
           +T + W + LY +      +   ++FV ++  GSF+++NL+L V++  + +E+ +A    
Sbjct: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420

Query: 438 AEQKEAEFQQMLEQLK--------------KQQEEA-------QAVAAASAASRDFSGIG 476
             QK  E QQ+ E LK              + +EE         ++  +   S +   + 
Sbjct: 421 DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS 480

Query: 477 GLGELLESSSEASKLSSKS--AKEWR--NRRKKRRQR 509
           G GE         +  SKS  ++ WR  NR  +RR R
Sbjct: 481 GEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCR 517



 Score =  143 bits (360), Expect = 2e-33
 Identities = 101/327 (30%), Positives = 157/327 (48%), Gaps = 42/327 (12%)

Query: 1195 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYI----EQRKTIKTMLEYADKVFTYI 1250
            +R+ C SIVE   F+ FI+  I  +  ALA   IYI    +   +    LE  +  F  I
Sbjct: 115  IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171

Query: 1251 FILEMLLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGA------- 1299
            F +E  LK +AYG       Y  N W  LDF+IV V L S++   L     G        
Sbjct: 172  FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231

Query: 1300 ----IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1355
                +K+LR  R LRPLR +S    ++VV+N+++ A+  ++++ L+ L   +I++I+G+ 
Sbjct: 232  GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291

Query: 1356 LFAGKFYHCVNMTTGNMFDISD------VNNLSDCQALGKQAR--WKNVK---VNFDNVG 1404
            LF GK +        ++    D        N   C A G + R  W        NFDN  
Sbjct: 292  LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFA 351

Query: 1405 AGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFI 1464
               L + Q  T +GW D++Y   D+   +L          ++YFV  +IFGSFF LNL +
Sbjct: 352  FAMLTVFQCITMEGWTDVLYWMNDAMGFELP---------WVYFVSLVIFGSFFVLNLVL 402

Query: 1465 GVIIDNFNQQKKKFGGQDIFMTEEQKK 1491
            GV+   F+++++K   +  F    +K+
Sbjct: 403  GVLSGEFSKEREKAKARGDFQKLREKQ 429



 Score =  131 bits (329), Expect = 8e-30
 Identities = 83/283 (29%), Positives = 143/283 (50%), Gaps = 42/283 (14%)

Query: 742  CCDAWLKVKHLVNLIVMDPF------------VDLAITICIVLNTLFMAMEHYPMTEQFS 789
            C +  LK + L   I  +P+             +  + + I+LNTL +AM+HY  ++ F+
Sbjct: 1175 CVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFN 1234

Query: 790  SVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE---- 845
              + + N+VFTG+FT EMVLK+IA  P  YF + WN FD +IV  S++++ LS  +    
Sbjct: 1235 DAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEE 1294

Query: 846  ----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 901
                 ++  R FR++R+ KL      +  L+     S  AL  + L++A++ FI+AV+GM
Sbjct: 1295 SNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGM 1354

Query: 902  QLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCME------- 953
            Q+FGK       +IN +      +   F  + L++FR   GE W E M  C+        
Sbjct: 1355 QMFGKVAMRDNNQINRNN-----NFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPE 1409

Query: 954  ---------VAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 987
                       G    ++ F+   ++   +++NLF+A+++ +F
Sbjct: 1410 SDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452



 Score =  127 bits (318), Expect = 1e-28
 Identities = 85/279 (30%), Positives = 149/279 (53%), Gaps = 25/279 (8%)

Query: 766  ITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWN 825
            + + + LNTL ++ EHY   +  + +  + N V   +FT EM++K+ ++    YF   +N
Sbjct: 529  VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 588

Query: 826  IFD-----GIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 880
             FD     G I    L+EL + +  G+SV R  RLLR+FK+ + W +L+ L+  + NS+ 
Sbjct: 589  RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 648

Query: 881  ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVL 940
            ++ +L L+L + + IF+++GMQLFG  +        D+    R   ++F  + L VF++L
Sbjct: 649  SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDETQTKRSTFDNFPQALLTVFQIL 702

Query: 941  CGE-WIETMWDCM------EVAGQTMCLIVFMLVMVIGNLVVLNLFLALL---LSSFSSD 990
             GE W   M+D +        +G  +C I F+++ + GN ++LN+FLA+    L+   S 
Sbjct: 703  TGEDWNAVMYDGIMAYGGPSSSGMIVC-IYFIILFICGNYILLNVFLAIAVDNLADAESL 761

Query: 991  NLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKA 1029
            N A  ++  E    +IA    ++ ++  KN   E  Q A
Sbjct: 762  NTAQKEEAEEKERKKIA---RKESLENKKNNKPEVNQIA 797



 Score =  106 bits (264), Expect = 3e-22
 Identities = 108/473 (22%), Positives = 195/473 (41%), Gaps = 89/473 (18%)

Query: 20   ESLAAIEKRAAEEKAKKP---KKEQDNDDENKPKPNSDLEAGKNL-------------PF 63
            ESL   +K  AEEK +K    K+  +N   NKP+ N    +   +             P+
Sbjct: 759  ESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPY 818

Query: 64   IYGDIPPEMVSEPLEDLDPYYI---NKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI 120
               D+P     E  E+ +P        +    +N  + I      SA +IL+  NP+R  
Sbjct: 819  PPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVG 878

Query: 121  AIKILVHSLFSMLIMCTILTNCVFMTLSNP---PDWTKNV----EYTFTGIYTFESLIKI 173
              K++ H +F+ LI+  I+ +   +   +P     +   +    +Y FT I+T E L+K+
Sbjct: 879  CHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKM 938

Query: 174  LARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA---LRTFRVLRALKTISVI 230
               G  L    F R+ +N LD  V+ ++ V+  +    +S    LR  RVLR L+ I+  
Sbjct: 939  TTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRA 998

Query: 231  PGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETN 290
             GLK +V  +  +++ + ++MI+T     +FA IG+QLF G               F   
Sbjct: 999  KGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGK--------------FYRC 1044

Query: 291  TTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGY 350
            T    +   +  G F+        +KD                          G      
Sbjct: 1045 TDEAKSNPEECRGLFI-------LYKD--------------------------GDVDSPV 1071

Query: 351  ICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKT----------Y 400
            +  +  +N ++   +FD    A ++LF + T + W  L    + + G+            
Sbjct: 1072 VRERIWQNSDF---NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEI 1128

Query: 401  MIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLK 453
             IFF++ I + +F+++N+ +  V + ++EQ +   +  E  + + Q +   LK
Sbjct: 1129 SIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1181



 Score =  104 bits (259), Expect = 1e-21
 Identities = 89/394 (22%), Positives = 161/394 (40%), Gaps = 52/394 (13%)

Query: 1118 EEFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKF 1177
            E+   E+E E  +E    TS     T  V       + E               GC    
Sbjct: 446  EDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENR-------------GCCGSL 492

Query: 1178 PFCQVSTEEGKGKIW--WNL--RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQR 1233
              CQ  ++    + W  WN   R+ C + V+   F   ++ ++ L++  ++ E  +  Q 
Sbjct: 493  --CQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQP 548

Query: 1234 KTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALG 1293
              +  + + A+KV   +F  EML+K  + G Q YF + +   D  +V   +   +   L 
Sbjct: 549  DWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELE 608

Query: 1294 YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMG 1353
                  I   R +R LR  +    +  +  +V +L+ ++ SI ++LL+  +F +IFS++G
Sbjct: 609  IMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLG 668

Query: 1354 VNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQV 1413
            + LF GKF                  N  + Q           +  FDN     L + Q+
Sbjct: 669  MQLFGGKF------------------NFDETQ---------TKRSTFDNFPQALLTVFQI 701

Query: 1414 ATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQ 1473
             T + W  +MY  +    +         + + +YF+I  I G++  LN+F+ + +DN   
Sbjct: 702  LTGEDWNAVMYDGI----MAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLAD 757

Query: 1474 QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1507
             +     Q     E+++K     + L +KK  KP
Sbjct: 758  AESLNTAQKEEAEEKERKKIARKESLENKKNNKP 791



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 89/385 (23%), Positives = 168/385 (43%), Gaps = 70/385 (18%)

Query: 670 LPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVS-----IASILTNTMEELEESRQ 724
           L  EG T++    K+ + S+Q +++    +   Q   +     + S+     ++  +S++
Sbjct: 34  LSGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKK 93

Query: 725 KCPPCWYRFANVFLIWDCCDAWLKVKHL-VNLIVMDPFVDLAITICIVLNTLFMAMEHYP 783
           +      R A       C      ++   ++++   PF D+ I + I  N + +A+ + P
Sbjct: 94  QGNSSNSRPARALF---CLSLNNPIRRACISIVEWKPF-DIFILLAIFANCVALAI-YIP 148

Query: 784 MTEQFSSVLTVGNL-----VFTGIFTAEMVLKIIA----MDPYYYFQEGWNIFDGIIVSL 834
             E  S+  T  NL      F  IFT E  LKIIA    + P  Y + GWN+ D +IV +
Sbjct: 149 FPEDDSNS-TNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIV 207

Query: 835 SLMELGLSNV----EG------------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNS 878
            L  + L  +    EG            +  LR+FR+LR  +L    P+L +++  I  +
Sbjct: 208 GLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKA 267

Query: 879 VGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV-----------------------CK 914
           +  L ++ L++  ++ I+A++G++LF GK +K C                        C 
Sbjct: 268 MVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCT 327

Query: 915 INDDCTLPRW--------HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFM 965
            N       W        + ++F  + L VF+ +  E W + ++   +  G  +  + F+
Sbjct: 328 ANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFV 387

Query: 966 LVMVIGNLVVLNLFLALLLSSFSSD 990
            +++ G+  VLNL L +L   FS +
Sbjct: 388 SLVIFGSFFVLNLVLGVLSGEFSKE 412



 Score = 81.3 bits (199), Expect = 9e-15
 Identities = 65/262 (24%), Positives = 125/262 (47%), Gaps = 22/262 (8%)

Query: 1532 IMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWN 1590
            +++L+ LN +T+  E  +Q  ++T +    N V + LFT E ++K+ SL    YF   +N
Sbjct: 529  VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 588

Query: 1591 IFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMM 1650
             FD  VV   I    L E+     +SP    V R  R+ RI ++ +    +  L+ +L+ 
Sbjct: 589  RFDCFVVCGGITETILVEL---EIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLN 645

Query: 1651 SLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKKEAGIDDMFNFETFGNSMICLFQITTSA 1709
            S+ ++ ++ LLLFL + I+++ GM  F      +        F+ F  +++ +FQI T  
Sbjct: 646  SMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGE 705

Query: 1710 GWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAV 1769
             W+ ++           D    + G S  G      +   +F+   I    +++N+++A+
Sbjct: 706  DWNAVM----------YDGIMAYGGPSSSG-----MIVCIYFIILFICGNYILLNVFLAI 750

Query: 1770 ILENFSVATEESAEPLSEDDFE 1791
             ++N  +A  ES     +++ E
Sbjct: 751  AVDN--LADAESLNTAQKEEAE 770



 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 80/374 (21%), Positives = 146/374 (39%), Gaps = 89/374 (23%)

Query: 1485 MTEEQKKYYNAMKKLGSKKPQKPIPRPA-----NKFQGMVFDFVTRQVFDISIMILICLN 1539
            +++ +++ Y   KK G+    +P          N  +      V  + FDI I++ I  N
Sbjct: 80   LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFAN 139

Query: 1540 MVTMMVET---DDQGKYMTLVLSRINLVFIVLFTGEFVLKLVS---LRH--YYFTIGWNI 1591
             V + +     +D        L ++   F+++FT E  LK+++   L H   Y   GWN+
Sbjct: 140  CVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNL 199

Query: 1592 FDFVVVILSIVGMFLAEMIEKYFVSPTL--------FRVIRLARIGRILRLIKGAKGIRT 1643
             DFV+VI+ +  + L ++ ++                + +R  R+ R LRL+ G   ++ 
Sbjct: 200  LDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQV 259

Query: 1644 LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-------------------------- 1677
            +L +++ ++  L +I LL+  V+ IYAI G+  F                          
Sbjct: 260  VLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAF 319

Query: 1678 ----------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS 1721
                             +V    GI    NF+ F  +M+ +FQ  T  GW  +L  +   
Sbjct: 320  SGNGRQCTANGTECRSGWVGPNGGIT---NFDNFAFAMLTVFQCITMEGWTDVLYWM--- 373

Query: 1722 APPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEES 1781
                              D     +   +FVS +I     V+N+ + V+   FS   +E 
Sbjct: 374  -----------------NDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS---KER 413

Query: 1782 AEPLSEDDFEMFYE 1795
             +  +  DF+   E
Sbjct: 414  EKAKARGDFQKLRE 427



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 61/264 (23%), Positives = 127/264 (48%), Gaps = 42/264 (15%)

Query: 766  ITICIVLNTLFMAMEHYPMTEQF-SSVLTVGNLVFTGIFTAEMVLKIIAMDPYY----YF 820
            I + I+L++  +A E    +  F +++L   +  FT IFT E++LK+     +     + 
Sbjct: 892  ILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFC 951

Query: 821  QEGWNIFDGIIVSLSLMELGL--SNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNS 878
            +  +N+ D ++V +SL+  G+  S +  + +LR  R+LR  +       L  +++ +  +
Sbjct: 952  RNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVA 1011

Query: 879  VGALGNLTLVLAIIVFIFAVVGMQLF-GKSYK----------EC-----VCKIND-DCTL 921
            +  +GN+ +V  ++ F+FA +G+QLF GK Y+          EC     + K  D D  +
Sbjct: 1012 IRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPV 1071

Query: 922  PR---WHMNDF-----FHSFLIVFRVLCGE-WIETMWDCMEVAGQTM---------CLIV 963
             R   W  +DF       + + +F V   E W   ++  ++  G+ +           I 
Sbjct: 1072 VRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIF 1131

Query: 964  FMLVMVIGNLVVLNLFLALLLSSF 987
            F++ ++I    ++N+F+  ++ +F
Sbjct: 1132 FIIYIIIVAFFMMNIFVGFVIVTF 1155



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 39/172 (22%), Positives = 83/172 (48%), Gaps = 19/172 (11%)

Query: 113  PLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPP------DWTKNVEYTFTGIYT 166
            P NP +     ++  S F  ++   I+ N + + + +        D    +   FTG++T
Sbjct: 1190 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 1249

Query: 167  FESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYV---------TEFVDLGNVSALRT 217
             E ++K++A     +   +  D WN  D  +++ + +         +E  +  +++  R 
Sbjct: 1250 VEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRL 1305

Query: 218  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
            FRV+R +K +S   G++T++   I+S + L  V +L      ++A+IG+Q+F
Sbjct: 1306 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF 1357



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 35/154 (22%), Positives = 69/154 (44%), Gaps = 16/154 (10%)

Query: 130 FSMLIMCTILTNCVFMTLS--NPPDWTKNVE----YTFTGIYTFESLIKILARGFCLEDF 183
           F  L++  +  N + ++    N PDW   ++         ++T E L+K+ + G      
Sbjct: 525 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ---- 580

Query: 184 TFLRDPWNWLDFSVI------VMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIV 237
            +    +N  D  V+       +    E +    +S  R  R+LR  K       L  +V
Sbjct: 581 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 640

Query: 238 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +L+ S+K ++ +++L    + +F+L+G+QLF G
Sbjct: 641 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 674



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 31/112 (27%), Positives = 57/112 (50%), Gaps = 12/112 (10%)

Query: 364 TSFDTFSWAFLSLFRLMTQDYWENLYQLTLRA------AGKTYMIFFVLVIFLGSFYLVN 417
           ++FD F  A L++F+++T + W  +    + A      +G    I+F+++   G++ L+N
Sbjct: 686 STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLN 745

Query: 418 LILAVVA---MAYEEQNQATLEEAEQKEAE---FQQMLEQLKKQQEEAQAVA 463
           + LA+        E  N A  EEAE+KE +    ++ LE  K  + E   +A
Sbjct: 746 VFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIA 797


>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform a [Homo sapiens]
          Length = 2353

 Score =  333 bits (855), Expect = 8e-91
 Identities = 206/656 (31%), Positives = 360/656 (54%), Gaps = 45/656 (6%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1255
            R +C  ++ H  F+  ++  I L+   +A E   I+   T +  L  ++ +FT IF+ EM
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343

Query: 1256 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1308
            ++K VA G       Y  ++W  LD L+V VSLV +V   A+A G   LG ++ LR LR 
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403

Query: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFY+C    
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463

Query: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
            T N      ++  + C+A     RW   K NFDN+G   ++L  +++  GW++IMY  +D
Sbjct: 1464 TRN------ISTKAQCRA--AHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLD 1515

Query: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1488
            +  V  QPV   N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1516 AVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEA-RRRE 1574

Query: 1489 QKKYYNAMKKLGSKKP-----QKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTM 1543
            +K+     ++  S  P     ++P     +  +  +    T    D+ I  +IC+N++TM
Sbjct: 1575 EKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITM 1634

Query: 1544 MVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSIV 1602
             +E  +Q K +   L   N VF ++F  E  LKLV+     +F   WN  D  +V+LS++
Sbjct: 1635 SMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLM 1694

Query: 1603 GMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL 1660
            G+ L   EM     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GL
Sbjct: 1695 GITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGL 1754

Query: 1661 LLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGLL 1715
            L  L+ FIYA  G+  F  ++        G+     F  FG + + LF+++T   W+G++
Sbjct: 1755 LFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIM 1814

Query: 1716 APILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFS 1775
               L     +C  +  H  S +      P++   +FV++++++  V+VN+ +AV++++  
Sbjct: 1815 KDTLR----ECSREDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLE 1864

Query: 1776 VATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSK---LSDFAAALDPPLLIAK 1828
             + +E+ E  +E D E+  E+ +   P + + ++  +     +   A D P L+A+
Sbjct: 1865 ESNKEARED-AELDAEIELEMAQ--GPGSARRVDADRPPLPQESPGARDAPNLVAR 1917



 Score =  141 bits (355), Expect = 7e-33
 Identities = 83/258 (32%), Positives = 145/258 (56%), Gaps = 9/258 (3%)

Query: 746  WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 805
            W+     +  IV   +    I + I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838

Query: 806  EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 865
            EM+LK++A  P  Y +  +NIFDGIIV +S+ E+      GLSVLR+FRLLRV KL +  
Sbjct: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898

Query: 866  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 924
            P L   + ++  ++  +     +L + +FIF+++GM LFG  +     K +   T+P R 
Sbjct: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS---LKTDTGDTVPDRK 955

Query: 925  HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 983
            + +    + + VF++L  E W   +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014

Query: 984  LSSFSSD---NLAATDDD 998
            +  F ++   N + TD+D
Sbjct: 1015 VEGFQAEGDANRSDTDED 1032



 Score =  132 bits (332), Expect = 3e-30
 Identities = 109/470 (23%), Positives = 204/470 (43%), Gaps = 95/470 (20%)

Query: 104 ATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTK------NV 157
           A +  + L      R   ++++ +  F  + M  I+ NCV + +  P +  +      N+
Sbjct: 76  AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135

Query: 158 EYTFTGI----YTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS 213
              F       +  E +IK++A G   +   +L D WN LDF ++V   +   +D  NVS
Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGLFGQK-CYLGDTWNRLDFFIVVAGMMEYSLDGHNVS 194

Query: 214 --ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
             A+RT RVLR L+ I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G
Sbjct: 195 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254

Query: 272 NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331
            LRN+C      DSAF  N          +N TF+                 ++   +G+
Sbjct: 255 LLRNRCF----LDSAFVRN----------NNLTFLR---------------PYYQTEEGE 285

Query: 332 KDPLLCGNGSDAGQ---------------CPEGY-------------------------- 350
           ++P +C +  D G                C  G+                          
Sbjct: 286 ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYN 345

Query: 351 ICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFL 410
           +C     NP+ G  +FD   +A++++F+++T + W ++    + A      I+F+L+I +
Sbjct: 346 VCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIV 405

Query: 411 GSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASR 470
           GSF+++NL L V+A  +          +E K+ E Q M EQ  +       +A+ S    
Sbjct: 406 GSFFMINLCLVVIATQF----------SETKQRESQLMREQRARHLSNDSTLASFSEPGS 455

Query: 471 DFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGER 520
            +  +  L  +     +  + S +    W++R +K+     ++G   G R
Sbjct: 456 CYEEL--LKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHR 503



 Score =  113 bits (282), Expect = 2e-24
 Identities = 143/670 (21%), Positives = 277/670 (41%), Gaps = 114/670 (17%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
            +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015

Query: 425  MAYEEQNQATLEEAEQKEAE--FQQMLEQLKK-QQEEAQAVAAASAASRDFSGIGGLGEL 481
              ++ +  A   + ++ +    F++   +L++ Q  E +  + A   +    G G L   
Sbjct: 1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPP 1075

Query: 482  LESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSM 541
            L   + A+ + +                            S P  ++  S+  S    S 
Sbjct: 1076 LIMCTAATPMPTPK--------------------------SSPFLDAAPSLPDSRRGSSS 1109

Query: 542  DGNRLTSDKKFCSPHQSLLSIRGSLFSPRR--NSKTSIFSFRGRAKDVGSENDFADDEHS 599
             G+    D+K   P  SL S   + + P    +S+ S +S  GRA  +       +    
Sbjct: 1110 SGDPPLGDQK---PPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGE---- 1162

Query: 600  TFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANG-KMHSTVDCNGVVSLVG 658
                    R+SL      GE + S   +A    R  PG  A   +   ++D   +     
Sbjct: 1163 --------RESLL----SGEGKGSTDDEAE-DGRAAPGPRATPLRRAESLDPRPLRPAAL 1209

Query: 659  GPSALTSPTGQ---LPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNT 715
             P+      GQ   LP +           R+ S++     L+D S     + +  +L   
Sbjct: 1210 PPTKCRDRDGQVVALPSDFFL--------RIDSHREDAAELDDDSEDSCCLRLHKVLEPY 1261

Query: 716  MEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTL 775
              +   SR+      +   N F +   C            ++     D  + + I LN +
Sbjct: 1262 KPQWCRSREAWALYLFSPQNRFRV--SCQK----------VITHKMFDHVVLVFIFLNCV 1309

Query: 776  FMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMVLKIIAMD----PYYYFQEGWNIFD 828
             +A+E  P  +  S+    L+V N +FT IF AEM++K++A+      + Y Q  WN+ D
Sbjct: 1310 TIALER-PDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLD 1368

Query: 829  GIIVSLSLMEL--------GLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 880
            G++V +SL+++        G   +  L VLR  R LR  ++    P L ++++ + +S+ 
Sbjct: 1369 GLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLR 1428

Query: 881  ALGNLTLVLAIIVFIFAVVGMQLF-GKSY-----------KECVCKINDDCTLPRWHMND 928
             +GN+ L+      IF ++G+QLF GK Y            +  C+      + R +  D
Sbjct: 1429 PIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFD 1488

Query: 929  FFHSFLIVFRVLCGE--WIETMWDCMEVAG---------QTMCLIVFMLVMVIGNLVVLN 977
                 L+   VL  +  W+  M+D ++  G             L+ F+  ++I +  VLN
Sbjct: 1489 NLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLN 1548

Query: 978  LFLALLLSSF 987
            +F+ +++ +F
Sbjct: 1549 MFVGVVVENF 1558



 Score =  109 bits (272), Expect = 3e-23
 Identities = 75/260 (28%), Positives = 128/260 (49%), Gaps = 27/260 (10%)

Query: 761  FVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYF 820
            ++DL IT  I +N + M+MEHY   +     L   N VFT +F  E  LK++A     +F
Sbjct: 1618 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1677

Query: 821  QEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKLAKSWPTLNM 870
            ++ WN  D  IV LSLM + L  +E           + ++R  R+ RV KL K    +  
Sbjct: 1678 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1737

Query: 871  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWH--MND 928
            L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      C  ++ C     H   ++
Sbjct: 1738 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGLSRHATFSN 1793

Query: 929  FFHSFLIVFRVLCGE-WIETMWDCMEVAGQ--TMCL--------IVFMLVMVIGNLVVLN 977
            F  +FL +FRV  G+ W   M D +    +    CL        + F+  +++   V++N
Sbjct: 1794 FGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1853

Query: 978  LFLALLLSSFSSDNLAATDD 997
            + +A+L+      N  A +D
Sbjct: 1854 VVVAVLMKHLEESNKEARED 1873



 Score =  106 bits (265), Expect = 2e-22
 Identities = 76/291 (26%), Positives = 138/291 (47%), Gaps = 38/291 (13%)

Query: 1511 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1568
            P N+F+      +T ++FD  +++ I LN VT+ +E    D G    + LS  N +F  +
Sbjct: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338

Query: 1569 FTGEFVLKLVSL-----RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1623
            F  E ++K+V+L      H Y    WN+ D ++V++S+V + +A           + RV+
Sbjct: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398

Query: 1624 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1677
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458

Query: 1678 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1723
                                  +   +NF+  G +++ LF +++  GW  ++   L++  
Sbjct: 1459 CEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518

Query: 1724 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1774
             D  P   H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1519 VDQQPVQNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 79/280 (28%), Positives = 128/280 (45%), Gaps = 28/280 (10%)

Query: 9    PGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDI 68
            PGP +  L   ESL   + R     A  P K +D D +    P SD        F+  D 
Sbjct: 1186 PGPRATPLRRAESL---DPRPLRPAALPPTKCRDRDGQVVALP-SDF-------FLRIDS 1234

Query: 69   PPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHS 128
              E  +E  +D +     +   ++        R     ALY+ +P N  R    K++ H 
Sbjct: 1235 HREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHK 1294

Query: 129  LFSMLIMCTILTNCVFMTLSNP---PDWTKNV-----EYTFTGIYTFESLIKILARGFCL 180
            +F  +++  I  NCV + L  P   P  T+ V      Y FT I+  E ++K++A G   
Sbjct: 1295 MFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLS 1354

Query: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGNVSALRTFRVLRALKTISVIP 231
             +  +L+  WN LD  +++++ V   V          LG +  LR  R LR L+ IS  P
Sbjct: 1355 GEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAP 1414

Query: 232  GLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            GLK +V  LI S++ + +++++      +F ++G+QLF G
Sbjct: 1415 GLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKG 1454



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 74/286 (25%), Positives = 133/286 (46%), Gaps = 40/286 (13%)

Query: 1189 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1248
            G++W         IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT
Sbjct: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833

Query: 1249 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1308
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V  A      G +  LRT R 
Sbjct: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA-----DGGLSVLRTFRL 888

Query: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
            LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  KF    ++ 
Sbjct: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKF----SLK 944

Query: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
            T     + D                   + NFD++    + + Q+ T + W  ++Y  + 
Sbjct: 945  TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 985

Query: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1474
            S           + +  LYFV  + FG++   NL + ++++ F  +
Sbjct: 986  S----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021



 Score = 91.3 bits (225), Expect = 9e-18
 Identities = 61/174 (35%), Positives = 93/174 (53%), Gaps = 19/174 (10%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1251
            R  C  +V + WFE   + +I+L+   L      ED+     +    +LE  D      F
Sbjct: 90   RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147

Query: 1252 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELG---AIKSLRT 1305
             +EM++K VA   +G + Y  + W  LDF IV       VA  + YS  G   ++ ++RT
Sbjct: 148  AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAIRT 200

Query: 1306 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 201  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 73/290 (25%), Positives = 131/290 (45%), Gaps = 41/290 (14%)

Query: 1515 FQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFV 1574
            F G +   V  + F   IM+ I +N ++M VE  +Q + +T  L   N+VF  +F  E +
Sbjct: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841

Query: 1575 LKLVSLRHY-YFTIGWNIFDFVVVILS---IVGMFLAEMIEKYFVSPTLFRVIRLARIGR 1630
            LKL++     Y    +NIFD ++V++S   IVG            +     V+R  R+ R
Sbjct: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQ-----------ADGGLSVLRTFRLLR 890

Query: 1631 ILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG-- 1685
            +L+L++    +R  L  L+ ++  +     LL L +FI++I GM  F     +K + G  
Sbjct: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950

Query: 1686 IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPS 1745
            + D  NF++   +++ +FQI T   W+ +L                       G     S
Sbjct: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSS 989

Query: 1746 VGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1795
                +FV+ +     V+ N+ +A+++E F    + +     ED   + +E
Sbjct: 990  WAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 41/132 (31%), Positives = 70/132 (53%), Gaps = 13/132 (9%)

Query: 1395 NVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIF 1454
            N  +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II 
Sbjct: 356  NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNFIYFILLIIV 405

Query: 1455 GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANK 1514
            GSFF +NL + VI   F++ K++   +   M E++ ++ +    L S            K
Sbjct: 406  GSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLK 462

Query: 1515 FQGMVFDFVTRQ 1526
            + G +F  V R+
Sbjct: 463  YVGHIFRKVKRR 474



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 48/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176
           +I+    FS  IM  IL N + M +     P + T  +E +   FT ++  E L+K+LA 
Sbjct: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847

Query: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G       ++R+P+N  D  +IV+  V E V    G +S LRTFR+LR LK +  +P L+
Sbjct: 848 G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++    L +  + +F+++G+ LF
Sbjct: 903 RQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 42/157 (26%), Positives = 80/157 (50%), Gaps = 8/157 (5%)

Query: 756 IVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 811
           +V +P+ +    + I+LN + + M    E      +  ++L   +      F  EMV+K+
Sbjct: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 812 IAMDPY---YYFQEGWNIFDGIIVSLSLMELGLSNVE-GLSVLRSFRLLRVFKLAKSWPT 867
           +A+  +    Y  + WN  D  IV   +ME  L      LS +R+ R+LR  +     P+
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215

Query: 868 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 904
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 44/198 (22%), Positives = 95/198 (47%), Gaps = 24/198 (12%)

Query: 115  NPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLS--NPP----DWTKNVEYTFTGIYTFE 168
            +P R+    +       + I   I  N + M++   N P    +  K   Y FT ++ FE
Sbjct: 1604 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFE 1663

Query: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA-----------LRT 217
            + +K++A GF      F +D WN LD ++++++ +   ++   +SA           +R 
Sbjct: 1664 AALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRV 1719

Query: 218  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC 277
             R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF    R +C
Sbjct: 1720 LRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFG---RLEC 1776

Query: 278  LQWPPSDSAFETNTTSYF 295
             +  P +      T S F
Sbjct: 1777 SEDNPCEGLSRHATFSNF 1794



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 48/159 (30%), Positives = 75/159 (47%), Gaps = 15/159 (9%)

Query: 1528 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHY 1583
            F+   M++I LN VT+ +    E  + G     +L   +      F  E V+K+V+L  +
Sbjct: 102  FEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLF 161

Query: 1584 ----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1639
                Y    WN  DF +V+  ++   L    + + VS      IR  R+ R LR I    
Sbjct: 162  GQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVS---LSAIRTVRVLRPLRAINRVP 214

Query: 1640 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1678
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 215  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 39/141 (27%), Positives = 65/141 (46%), Gaps = 19/141 (13%)

Query: 345  QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGK------ 398
            +C E   C    R     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1775 ECSEDNPCEGLSR-----HATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCL 1829

Query: 399  TYM-----IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAE---QKEAEFQQMLE 450
            +Y+     ++FV  + +  F LVN+++AV+    EE N+   E+AE   + E E  Q   
Sbjct: 1830 SYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQGPG 1889

Query: 451  QLKKQQEEAQAVAAASAASRD 471
              ++   +   +   S  +RD
Sbjct: 1890 SARRVDADRPPLPQESPGARD 1910



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 931 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 988
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 366 YAWIAIFQVITLEGWVDIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 423



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1691 NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFF 1750
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 360  NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA---------------------HSFYNFIY 398

Query: 1751 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1787
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 399  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 435


>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
            isoform 3 [Homo sapiens]
          Length = 2343

 Score =  333 bits (853), Expect = 1e-90
 Identities = 199/609 (32%), Positives = 338/609 (55%), Gaps = 43/609 (7%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1255
            R  C+ I+ H  F+  ++ +I L+   +A E   I+     +  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1256 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANAL---GYSELGAIKSLRTLRA 1308
             +K VA G+    Q Y  ++W  LD L+V +S++ ++ + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422

Query: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
            T N      + N SDC       RW   K NFDN+G   ++L  +A+  GW+DIMY  +D
Sbjct: 1423 TRN------ITNKSDCAEASY--RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474

Query: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1488
            +  V  QP+   N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRRE 1533

Query: 1489 QKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVT 1542
            +K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN+VT
Sbjct: 1534 EKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVT 1593

Query: 1543 MMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSI 1601
            M +E   Q + +   L   N +F V+F  E V KLV+     +F   WN  D  +V+LSI
Sbjct: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653

Query: 1602 VGMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG 1659
            +G+ L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + N+G
Sbjct: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713

Query: 1660 LLLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGL 1714
            LL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W+G+
Sbjct: 1714 LLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGI 1773

Query: 1715 LAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1774
            +   L     DCD ++          C N  +   +FVS+++ +  V+VN+ IAV++++ 
Sbjct: 1774 MKDTLR----DCDQES---------TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL 1820

Query: 1775 SVATEESAE 1783
              + +E+ E
Sbjct: 1821 EESNKEAKE 1829



 Score =  140 bits (354), Expect = 1e-32
 Identities = 78/247 (31%), Positives = 139/247 (56%), Gaps = 7/247 (2%)

Query: 746 WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 805
           W  +      IV   +    I I I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 806 EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 865
           EM+LK++   P+ Y +  +NIFDG+IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 866 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 924
           P L   + ++  ++  +    ++L + +FIF+++GM LFG  +        D  TLP R 
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERDGDTLPDRK 904

Query: 925 HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 983
           + +    + + VF++L  E W + +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAIL 963

Query: 984 LSSFSSD 990
           +  F ++
Sbjct: 964 VEGFQAE 970



 Score =  122 bits (307), Expect = 3e-27
 Identities = 97/377 (25%), Positives = 171/377 (45%), Gaps = 48/377 (12%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + +  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF +++   +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDS 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C        
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 286 AFETNTTSYFNGTMDSNGTFV------NVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGN 339
               +   Y+    +    F+      N   S  +     GD        G   P  CG 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGD-------GGGGPP--CGL 300

Query: 340 GSDAGQCPEGYICV---------KAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLY 389
             +A        CV          AG  NP  G  +FD   +A++++F+++T + W ++ 
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 390 QLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 449
              + A      I+F+L+I +GSF+++NL L V+A  +          +E K+ E Q M 
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SETKQRESQLMR 410

Query: 450 EQLKKQQEEAQAVAAAS 466
           EQ  +    A  +A+ S
Sbjct: 411 EQRVRFLSNASTLASFS 427



 Score =  113 bits (282), Expect = 2e-24
 Identities = 148/690 (21%), Positives = 278/690 (40%), Gaps = 144/690 (20%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 425  MAYEEQNQATLEEAEQK----------EAEFQQMLEQLKKQQEEAQAV-------AAASA 467
              ++ +  A   E+E            + +    L  L +  E  +++        AA+ 
Sbjct: 965  EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024

Query: 468  ASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSE 527
             S   S   GLGE L  +S  +  SS SA+       K         ++       P S 
Sbjct: 1025 MSLPKSTSTGLGEALGPASRRTS-SSGSAEPGAAHEMKSPPSARSSPHS-------PWSA 1076

Query: 528  SEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDV 587
            +     R S   S+        +      +SLLS                    G  ++ 
Sbjct: 1077 ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLS--------------------GEGQES 1116

Query: 588  GSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGL----PANGK 643
              E + +++E ++   S+ R       HR    R +  S     +  VPGL       G 
Sbjct: 1117 QDEEESSEEERASPAGSDHR-------HRGSLEREAKSSFDLPDTLQVPGLHRTASGRGS 1169

Query: 644  MHSTVDCNGVVSLVGGPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQ 703
                 DCNG            S +G+L           R  R     +  +  +D     
Sbjct: 1170 ASEHQDCNG-----------KSASGRL----------ARALRPDDPPLDGDDADDEGNLS 1208

Query: 704  RAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWL-----KVKHLVNLIVM 758
            +   + + +          R + P C        L  D   A++     + + L + I+ 
Sbjct: 1209 KGERVRAWI----------RARLPACC-------LERDSWSAYIFPPQSRFRLLCHRIIT 1251

Query: 759  DPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMVLKIIAMD 815
                D  + + I LN + +AME  P  +  S+    LT+ N +FT +F AEM +K++A+ 
Sbjct: 1252 HKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALG 1310

Query: 816  PYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLLRVFKLAK 863
              +    Y +  WN+ DG++V +S++++ +S V          L VLR  R LR  ++  
Sbjct: 1311 WCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVIS 1370

Query: 864  SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECVCKIND----- 917
                L ++++ + +S+  +GN+ ++      IF ++G+QLF GK +   VC+  D     
Sbjct: 1371 RAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF---VCQGEDTRNIT 1427

Query: 918  ---DCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG---------Q 957
               DC     RW  H  +F      L+   VL  +  W++ M+D ++  G          
Sbjct: 1428 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1487

Query: 958  TMCLIVFMLVMVIGNLVVLNLFLALLLSSF 987
               L+ F+  ++I    VLN+F+ +++ +F
Sbjct: 1488 PWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  110 bits (274), Expect = 2e-23
 Identities = 79/266 (29%), Positives = 131/266 (49%), Gaps = 24/266 (9%)

Query: 752  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 811
            LV+ +    ++DL IT  I LN + MAMEHY   +     L + N +FT IF  E V K+
Sbjct: 1569 LVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKL 1628

Query: 812  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKL 861
            +A     +FQ+ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 1629 VAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKL 1688

Query: 862  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 921
             K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C  
Sbjct: 1689 LKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEG 1744

Query: 922  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVA---GQTMCLIVFMLVMVIG 971
               H    +F  +FL +FRV  G+ W     +T+ DC + +      +  I F+  ++  
Sbjct: 1745 LGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804

Query: 972  NLVVLNLFLALLLSSFSSDNLAATDD 997
              V++N+ +A+L+      N  A ++
Sbjct: 1805 QFVLVNVVIAVLMKHLEESNKEAKEE 1830



 Score =  105 bits (262), Expect = 4e-22
 Identities = 87/393 (22%), Positives = 163/393 (41%), Gaps = 90/393 (22%)

Query: 109  YILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + +  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 272  NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331
                                                                 F+V  G+
Sbjct: 1414 K----------------------------------------------------FFVCQGE 1421

Query: 332  KDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQL 391
             D     N SD  +    ++  K      Y +   D    A +SLF L ++D W ++   
Sbjct: 1422 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 392  TLRAAG----------KTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ-ATLEEAEQ 440
             L A G             +++F+  + + +F+++N+ + VV   + +  Q    EEA +
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531

Query: 441  KEAEFQQMLEQLKKQQEEAQAVAAASAASRDFS 473
            +E +  + LE+ ++ +E+  A A       D+S
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1564



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 41/283 (14%)

Query: 1192 WWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1251
            W  +  T   IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT +F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786

Query: 1252 ILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRP 1311
             LEMLLK + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R 
Sbjct: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRV 841

Query: 1312 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGN 1371
            L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF          
Sbjct: 842  LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA--------- 892

Query: 1372 MFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1431
                 D + L D             + NFD++    + + Q+ T + W  ++Y  + S  
Sbjct: 893  --SERDGDTLPD-------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST- 936

Query: 1432 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1474
                     + +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 937  ---------SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 91.3 bits (225), Expect = 9e-18
 Identities = 61/174 (35%), Positives = 96/174 (55%), Gaps = 19/174 (10%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1251
            R  C   V + WFE   + +ILL+   L      EDI  + ++  + +  + D +F + F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128

Query: 1252 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYS---ELGAIKSLRT 1305
             +EM++K VA   +G + Y  + W  LDF IV       +A  L YS   +  +  ++RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1306 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235



 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 71/273 (26%), Positives = 129/273 (47%), Gaps = 35/273 (12%)

Query: 1523 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1582
            V  + F   IMI I +N ++M +E  +Q + +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1583 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1641
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL R+   L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPAL 851

Query: 1642 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS----NFAYVKKEAGIDDMFNFETFGN 1697
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1698 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1757
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1758 SFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1790
               V+ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 35/104 (33%), Positives = 61/104 (58%), Gaps = 13/104 (12%)

Query: 1398 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1457
            +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1458 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1501
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 47/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  VIV+  V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/175 (26%), Positives = 88/175 (50%), Gaps = 11/175 (6%)

Query: 757 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKII 812
           V +P+ +    + I+LN + + M    E      Q   +L   +      F  EMV+K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 813 AMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWPT 867
           A+  +    Y  + WN  D  IV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 868 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP 922
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+    +   C + ++ +LP
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN-RCFLPENFSLP 250



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 68/313 (21%), Positives = 130/313 (41%), Gaps = 87/313 (27%)

Query: 155  KNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA 214
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   V+A
Sbjct: 1610 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1665

Query: 215  -----------LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 263
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1666 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1725

Query: 264  IGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFN-WKDYIGDD 322
            +G++LF G+L  +C +  P +              +  + TF N  M+    ++   GD+
Sbjct: 1726 LGVELF-GDL--ECDETHPCEG-------------LGRHATFRNFGMAFLTLFRVSTGDN 1769

Query: 323  SHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 382
             +  + D  +D            C +   C     +P Y + SF                
Sbjct: 1770 WNGIMKDTLRD------------CDQESTCYNTVISPIY-FVSF---------------- 1800

Query: 383  DYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKE 442
                                     +    F LVN+++AV+    EE N+   EEAE  E
Sbjct: 1801 -------------------------VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LE 1834

Query: 443  AEFQQMLEQLKKQ 455
            AE +  ++ L  Q
Sbjct: 1835 AELELEMKTLSPQ 1847



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 46/159 (28%), Positives = 71/159 (44%), Gaps = 15/159 (9%)

Query: 1528 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL--- 1580
            F+   M++I LN VT+ +    E          +L   +      F  E V+K+V+L   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1581 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1639
             +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195

Query: 1640 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1678
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 931 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 988
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 23/116 (19%), Positives = 46/116 (39%), Gaps = 25/116 (21%)

Query: 1676 NFAYVKKEAGIDDMF----NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1731
            N  Y    AG  + F    NF+  G + I +FQ+ T  GW  ++  ++++          
Sbjct: 317  NQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------- 366

Query: 1732 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1787
                       +      +F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 367  -----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
            isoform 12 [Homo sapiens]
          Length = 2250

 Score =  333 bits (853), Expect = 1e-90
 Identities = 199/609 (32%), Positives = 338/609 (55%), Gaps = 43/609 (7%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1255
            R  C+ I+ H  F+  ++ +I L+   +A E   I+     +  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1256 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANAL---GYSELGAIKSLRTLRA 1308
             +K VA G+    Q Y  ++W  LD L+V +S++ ++ + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422

Query: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
            T N      + N SDC       RW   K NFDN+G   ++L  +A+  GW+DIMY  +D
Sbjct: 1423 TRN------ITNKSDCAEASY--RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474

Query: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1488
            +  V  QP+   N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRRE 1533

Query: 1489 QKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVT 1542
            +K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN+VT
Sbjct: 1534 EKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVT 1593

Query: 1543 MMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSI 1601
            M +E   Q + +   L   N +F V+F  E V KLV+     +F   WN  D  +V+LSI
Sbjct: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653

Query: 1602 VGMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG 1659
            +G+ L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + N+G
Sbjct: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713

Query: 1660 LLLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGL 1714
            LL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W+G+
Sbjct: 1714 LLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGI 1773

Query: 1715 LAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1774
            +   L     DCD ++          C N  +   +FVS+++ +  V+VN+ IAV++++ 
Sbjct: 1774 MKDTLR----DCDQES---------TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL 1820

Query: 1775 SVATEESAE 1783
              + +E+ E
Sbjct: 1821 EESNKEAKE 1829



 Score =  140 bits (354), Expect = 1e-32
 Identities = 78/247 (31%), Positives = 139/247 (56%), Gaps = 7/247 (2%)

Query: 746 WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 805
           W  +      IV   +    I I I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 806 EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 865
           EM+LK++   P+ Y +  +NIFDG+IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 866 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 924
           P L   + ++  ++  +    ++L + +FIF+++GM LFG  +        D  TLP R 
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERDGDTLPDRK 904

Query: 925 HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 983
           + +    + + VF++L  E W + +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAIL 963

Query: 984 LSSFSSD 990
           +  F ++
Sbjct: 964 VEGFQAE 970



 Score =  122 bits (307), Expect = 3e-27
 Identities = 97/377 (25%), Positives = 171/377 (45%), Gaps = 48/377 (12%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + +  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF +++   +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDS 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C        
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 286 AFETNTTSYFNGTMDSNGTFV------NVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGN 339
               +   Y+    +    F+      N   S  +     GD        G   P  CG 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGD-------GGGGPP--CGL 300

Query: 340 GSDAGQCPEGYICV---------KAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLY 389
             +A        CV          AG  NP  G  +FD   +A++++F+++T + W ++ 
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 390 QLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 449
              + A      I+F+L+I +GSF+++NL L V+A  +          +E K+ E Q M 
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SETKQRESQLMR 410

Query: 450 EQLKKQQEEAQAVAAAS 466
           EQ  +    A  +A+ S
Sbjct: 411 EQRVRFLSNASTLASFS 427



 Score =  113 bits (282), Expect = 2e-24
 Identities = 148/690 (21%), Positives = 278/690 (40%), Gaps = 144/690 (20%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 425  MAYEEQNQATLEEAEQK----------EAEFQQMLEQLKKQQEEAQAV-------AAASA 467
              ++ +  A   E+E            + +    L  L +  E  +++        AA+ 
Sbjct: 965  EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024

Query: 468  ASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSE 527
             S   S   GLGE L  +S  +  SS SA+       K         ++       P S 
Sbjct: 1025 MSLPKSTSTGLGEALGPASRRTS-SSGSAEPGAAHEMKSPPSARSSPHS-------PWSA 1076

Query: 528  SEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDV 587
            +     R S   S+        +      +SLLS                    G  ++ 
Sbjct: 1077 ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLS--------------------GEGQES 1116

Query: 588  GSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGL----PANGK 643
              E + +++E ++   S+ R       HR    R +  S     +  VPGL       G 
Sbjct: 1117 QDEEESSEEERASPAGSDHR-------HRGSLEREAKSSFDLPDTLQVPGLHRTASGRGS 1169

Query: 644  MHSTVDCNGVVSLVGGPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQ 703
                 DCNG            S +G+L           R  R     +  +  +D     
Sbjct: 1170 ASEHQDCNG-----------KSASGRL----------ARALRPDDPPLDGDDADDEGNLS 1208

Query: 704  RAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWL-----KVKHLVNLIVM 758
            +   + + +          R + P C        L  D   A++     + + L + I+ 
Sbjct: 1209 KGERVRAWI----------RARLPACC-------LERDSWSAYIFPPQSRFRLLCHRIIT 1251

Query: 759  DPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMVLKIIAMD 815
                D  + + I LN + +AME  P  +  S+    LT+ N +FT +F AEM +K++A+ 
Sbjct: 1252 HKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALG 1310

Query: 816  PYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLLRVFKLAK 863
              +    Y +  WN+ DG++V +S++++ +S V          L VLR  R LR  ++  
Sbjct: 1311 WCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVIS 1370

Query: 864  SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECVCKIND----- 917
                L ++++ + +S+  +GN+ ++      IF ++G+QLF GK +   VC+  D     
Sbjct: 1371 RAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF---VCQGEDTRNIT 1427

Query: 918  ---DCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG---------Q 957
               DC     RW  H  +F      L+   VL  +  W++ M+D ++  G          
Sbjct: 1428 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1487

Query: 958  TMCLIVFMLVMVIGNLVVLNLFLALLLSSF 987
               L+ F+  ++I    VLN+F+ +++ +F
Sbjct: 1488 PWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  110 bits (274), Expect = 2e-23
 Identities = 79/266 (29%), Positives = 131/266 (49%), Gaps = 24/266 (9%)

Query: 752  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 811
            LV+ +    ++DL IT  I LN + MAMEHY   +     L + N +FT IF  E V K+
Sbjct: 1569 LVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKL 1628

Query: 812  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKL 861
            +A     +FQ+ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 1629 VAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKL 1688

Query: 862  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 921
             K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C  
Sbjct: 1689 LKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEG 1744

Query: 922  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVA---GQTMCLIVFMLVMVIG 971
               H    +F  +FL +FRV  G+ W     +T+ DC + +      +  I F+  ++  
Sbjct: 1745 LGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804

Query: 972  NLVVLNLFLALLLSSFSSDNLAATDD 997
              V++N+ +A+L+      N  A ++
Sbjct: 1805 QFVLVNVVIAVLMKHLEESNKEAKEE 1830



 Score =  105 bits (262), Expect = 4e-22
 Identities = 87/393 (22%), Positives = 163/393 (41%), Gaps = 90/393 (22%)

Query: 109  YILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + +  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 272  NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331
                                                                 F+V  G+
Sbjct: 1414 K----------------------------------------------------FFVCQGE 1421

Query: 332  KDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQL 391
             D     N SD  +    ++  K      Y +   D    A +SLF L ++D W ++   
Sbjct: 1422 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 392  TLRAAG----------KTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ-ATLEEAEQ 440
             L A G             +++F+  + + +F+++N+ + VV   + +  Q    EEA +
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531

Query: 441  KEAEFQQMLEQLKKQQEEAQAVAAASAASRDFS 473
            +E +  + LE+ ++ +E+  A A       D+S
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1564



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 41/283 (14%)

Query: 1192 WWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1251
            W  +  T   IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT +F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786

Query: 1252 ILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRP 1311
             LEMLLK + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R 
Sbjct: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRV 841

Query: 1312 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGN 1371
            L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF          
Sbjct: 842  LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA--------- 892

Query: 1372 MFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1431
                 D + L D             + NFD++    + + Q+ T + W  ++Y  + S  
Sbjct: 893  --SERDGDTLPD-------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST- 936

Query: 1432 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1474
                     + +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 937  ---------SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 91.3 bits (225), Expect = 9e-18
 Identities = 61/174 (35%), Positives = 96/174 (55%), Gaps = 19/174 (10%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1251
            R  C   V + WFE   + +ILL+   L      EDI  + ++  + +  + D +F + F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128

Query: 1252 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYS---ELGAIKSLRT 1305
             +EM++K VA   +G + Y  + W  LDF IV       +A  L YS   +  +  ++RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1306 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235



 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 71/273 (26%), Positives = 129/273 (47%), Gaps = 35/273 (12%)

Query: 1523 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1582
            V  + F   IMI I +N ++M +E  +Q + +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1583 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1641
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL R+   L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPAL 851

Query: 1642 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS----NFAYVKKEAGIDDMFNFETFGN 1697
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1698 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1757
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1758 SFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1790
               V+ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 35/104 (33%), Positives = 61/104 (58%), Gaps = 13/104 (12%)

Query: 1398 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1457
            +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1458 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1501
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 47/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  VIV+  V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/175 (26%), Positives = 88/175 (50%), Gaps = 11/175 (6%)

Query: 757 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKII 812
           V +P+ +    + I+LN + + M    E      Q   +L   +      F  EMV+K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 813 AMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWPT 867
           A+  +    Y  + WN  D  IV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 868 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP 922
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+    +   C + ++ +LP
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN-RCFLPENFSLP 250



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 68/313 (21%), Positives = 130/313 (41%), Gaps = 87/313 (27%)

Query: 155  KNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA 214
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   V+A
Sbjct: 1610 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1665

Query: 215  -----------LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 263
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1666 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1725

Query: 264  IGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFN-WKDYIGDD 322
            +G++LF G+L  +C +  P +              +  + TF N  M+    ++   GD+
Sbjct: 1726 LGVELF-GDL--ECDETHPCEG-------------LGRHATFRNFGMAFLTLFRVSTGDN 1769

Query: 323  SHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 382
             +  + D  +D            C +   C     +P Y + SF                
Sbjct: 1770 WNGIMKDTLRD------------CDQESTCYNTVISPIY-FVSF---------------- 1800

Query: 383  DYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKE 442
                                     +    F LVN+++AV+    EE N+   EEAE  E
Sbjct: 1801 -------------------------VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LE 1834

Query: 443  AEFQQMLEQLKKQ 455
            AE +  ++ L  Q
Sbjct: 1835 AELELEMKTLSPQ 1847



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 46/159 (28%), Positives = 71/159 (44%), Gaps = 15/159 (9%)

Query: 1528 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL--- 1580
            F+   M++I LN VT+ +    E          +L   +      F  E V+K+V+L   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1581 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1639
             +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195

Query: 1640 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1678
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 931 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 988
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 23/116 (19%), Positives = 46/116 (39%), Gaps = 25/116 (21%)

Query: 1676 NFAYVKKEAGIDDMF----NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1731
            N  Y    AG  + F    NF+  G + I +FQ+ T  GW  ++  ++++          
Sbjct: 317  NQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------- 366

Query: 1732 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1787
                       +      +F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 367  -----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
            isoform 5 [Homo sapiens]
          Length = 2321

 Score =  333 bits (853), Expect = 1e-90
 Identities = 199/609 (32%), Positives = 338/609 (55%), Gaps = 43/609 (7%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1255
            R  C+ I+ H  F+  ++ +I L+   +A E   I+     +  L  ++ +FT +F+ EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325

Query: 1256 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANAL---GYSELGAIKSLRTLRA 1308
             +K VA G+    Q Y  ++W  LD L+V +S++ ++ + +   G   LG ++ LR LR 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1445

Query: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
            T N      + N SDC       RW   K NFDN+G   ++L  +A+  GW+DIMY  +D
Sbjct: 1446 TRN------ITNKSDCAEASY--RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1497

Query: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1488
            +  V  QP+   N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1498 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRRE 1556

Query: 1489 QKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVT 1542
            +K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN+VT
Sbjct: 1557 EKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVT 1616

Query: 1543 MMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSI 1601
            M +E   Q + +   L   N +F V+F  E V KLV+     +F   WN  D  +V+LSI
Sbjct: 1617 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1676

Query: 1602 VGMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG 1659
            +G+ L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + N+G
Sbjct: 1677 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1736

Query: 1660 LLLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGL 1714
            LL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W+G+
Sbjct: 1737 LLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGI 1796

Query: 1715 LAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1774
            +   L     DCD ++          C N  +   +FVS+++ +  V+VN+ IAV++++ 
Sbjct: 1797 MKDTLR----DCDQES---------TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL 1843

Query: 1775 SVATEESAE 1783
              + +E+ E
Sbjct: 1844 EESNKEAKE 1852



 Score =  145 bits (365), Expect = 5e-34
 Identities = 81/266 (30%), Positives = 150/266 (56%), Gaps = 8/266 (3%)

Query: 746  WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 805
            W  +      IV   +    I I I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 806  EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 865
            EM+LK++   P+ Y +  +NIFDG+IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 866  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 924
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  +        D  TLP R 
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERDGDTLPDRK 904

Query: 925  HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 983
            + +    + + VF++L  E W + +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAIL 963

Query: 984  LSSFSSDNLAATDD-DNEMNNLQIAV 1008
            +  F ++ ++  +D   +++ +Q+ V
Sbjct: 964  VEGFQAEEISKREDASGQLSCIQLPV 989



 Score =  122 bits (307), Expect = 3e-27
 Identities = 97/377 (25%), Positives = 171/377 (45%), Gaps = 48/377 (12%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + +  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF +++   +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDS 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C        
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 286 AFETNTTSYFNGTMDSNGTFV------NVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGN 339
               +   Y+    +    F+      N   S  +     GD        G   P  CG 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGD-------GGGGPP--CGL 300

Query: 340 GSDAGQCPEGYICV---------KAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLY 389
             +A        CV          AG  NP  G  +FD   +A++++F+++T + W ++ 
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 390 QLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 449
              + A      I+F+L+I +GSF+++NL L V+A  +          +E K+ E Q M 
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SETKQRESQLMR 410

Query: 450 EQLKKQQEEAQAVAAAS 466
           EQ  +    A  +A+ S
Sbjct: 411 EQRVRFLSNASTLASFS 427



 Score =  111 bits (278), Expect = 6e-24
 Identities = 156/700 (22%), Positives = 287/700 (41%), Gaps = 141/700 (20%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 425  MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLES 484
              ++ +     E +++++A  Q    QL    +   A  + S        + G G+  + 
Sbjct: 965  EGFQAE-----EISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKC 1019

Query: 485  SSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESED-------SVKRSSF 537
                  L+  S  E    RK       L  +      S PKS S         + +R+S 
Sbjct: 1020 ------LALVSLGEHPELRKSLLPP--LIIHTAATPMSLPKSTSTGLGEALGPASRRTSS 1071

Query: 538  LFSMDGNRLTSDKK----FCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDV------ 587
              S +       K       SPH    +   S ++ RR+S+ S+    GRA  +      
Sbjct: 1072 SGSAEPGAAHEMKSPPSARSSPHSPWSA--ASSWTSRRSSRNSL----GRAPSLKRRSPS 1125

Query: 588  --------GSENDFADDEHSTFEDSESRRDSLFVPHRH--GERRNSNVSQASMSSRMVPG 637
                    G   +  D+E S+ E+  S   S    HRH     R +  S     +  VPG
Sbjct: 1126 GERRSLLSGEGQESQDEEESSEEERASPAGS---DHRHRGSLEREAKSSFDLPDTLQVPG 1182

Query: 638  L----PANGKMHSTVDCNGVVSLVGGPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISM 693
            L       G      DCNG            S +G+L           R  R     +  
Sbjct: 1183 LHRTASGRGSASEHQDCNG-----------KSASGRL----------ARALRPDDPPLDG 1221

Query: 694  EMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWL-----K 748
            +  +D     +   + + +          R + P C        L  D   A++     +
Sbjct: 1222 DDADDEGNLSKGERVRAWI----------RARLPACC-------LERDSWSAYIFPPQSR 1264

Query: 749  VKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTA 805
             + L + I+     D  + + I LN + +AME  P  +  S+    LT+ N +FT +F A
Sbjct: 1265 FRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAVFLA 1323

Query: 806  EMVLKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSF 853
            EM +K++A+   +    Y +  WN+ DG++V +S++++ +S V          L VLR  
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383

Query: 854  RLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 912
            R LR  ++      L ++++ + +S+  +GN+ ++      IF ++G+QLF GK +   V
Sbjct: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF---V 1440

Query: 913  CKIND--------DCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG 956
            C+  D        DC     RW  H  +F      L+   VL  +  W++ M+D ++  G
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500

Query: 957  ---------QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 987
                         L+ F+  ++I    VLN+F+ +++ +F
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  110 bits (274), Expect = 2e-23
 Identities = 79/266 (29%), Positives = 131/266 (49%), Gaps = 24/266 (9%)

Query: 752  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 811
            LV+ +    ++DL IT  I LN + MAMEHY   +     L + N +FT IF  E V K+
Sbjct: 1592 LVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKL 1651

Query: 812  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKL 861
            +A     +FQ+ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 1652 VAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKL 1711

Query: 862  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 921
             K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C  
Sbjct: 1712 LKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEG 1767

Query: 922  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVA---GQTMCLIVFMLVMVIG 971
               H    +F  +FL +FRV  G+ W     +T+ DC + +      +  I F+  ++  
Sbjct: 1768 LGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1827

Query: 972  NLVVLNLFLALLLSSFSSDNLAATDD 997
              V++N+ +A+L+      N  A ++
Sbjct: 1828 QFVLVNVVIAVLMKHLEESNKEAKEE 1853



 Score =  105 bits (262), Expect = 4e-22
 Identities = 87/393 (22%), Positives = 163/393 (41%), Gaps = 90/393 (22%)

Query: 109  YILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + +  P     + E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 272  NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331
                                                                 F+V  G+
Sbjct: 1437 K----------------------------------------------------FFVCQGE 1444

Query: 332  KDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQL 391
             D     N SD  +    ++  K      Y +   D    A +SLF L ++D W ++   
Sbjct: 1445 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1494

Query: 392  TLRAAG----------KTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ-ATLEEAEQ 440
             L A G             +++F+  + + +F+++N+ + VV   + +  Q    EEA +
Sbjct: 1495 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1554

Query: 441  KEAEFQQMLEQLKKQQEEAQAVAAASAASRDFS 473
            +E +  + LE+ ++ +E+  A A       D+S
Sbjct: 1555 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1587



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 70/284 (24%), Positives = 133/284 (46%), Gaps = 41/284 (14%)

Query: 1192 WWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1251
            W  +  T   IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT +F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786

Query: 1252 ILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRP 1311
             LEMLLK + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R 
Sbjct: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRV 841

Query: 1312 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGN 1371
            L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF          
Sbjct: 842  LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA--------- 892

Query: 1372 MFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1431
                 D + L D             + NFD++    + + Q+ T + W  ++Y  + S  
Sbjct: 893  --SERDGDTLPD-------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST- 936

Query: 1432 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1475
                     + +  LYF+  + FG++   NL + ++++ F  ++
Sbjct: 937  ---------SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971



 Score = 91.3 bits (225), Expect = 9e-18
 Identities = 61/174 (35%), Positives = 96/174 (55%), Gaps = 19/174 (10%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1251
            R  C   V + WFE   + +ILL+   L      EDI  + ++  + +  + D +F + F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128

Query: 1252 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYS---ELGAIKSLRT 1305
             +EM++K VA   +G + Y  + W  LDF IV       +A  L YS   +  +  ++RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1306 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 68/269 (25%), Positives = 123/269 (45%), Gaps = 34/269 (12%)

Query: 1523 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1582
            V  + F   IMI I +N ++M +E  +Q + +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1583 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1641
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL    R+L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISV-----WEIVGQQGGGLSVLRTFRLM---RVLKLVRFLPAL 851

Query: 1642 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKKEAGIDDMFNFETFGN 1697
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1698 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1757
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1758 SFLVVVNMYIAVILENFSVATEESAEPLS 1786
               V+ N+ +A+++E F        E  S
Sbjct: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 35/104 (33%), Positives = 61/104 (58%), Gaps = 13/104 (12%)

Query: 1398 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1457
            +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1458 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1501
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 47/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  VIV+  V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/175 (26%), Positives = 88/175 (50%), Gaps = 11/175 (6%)

Query: 757 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKII 812
           V +P+ +    + I+LN + + M    E      Q   +L   +      F  EMV+K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 813 AMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWPT 867
           A+  +    Y  + WN  D  IV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 868 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP 922
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+    +   C + ++ +LP
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN-RCFLPENFSLP 250



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 68/313 (21%), Positives = 130/313 (41%), Gaps = 87/313 (27%)

Query: 155  KNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA 214
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   V+A
Sbjct: 1633 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1688

Query: 215  -----------LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 263
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1689 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1748

Query: 264  IGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFN-WKDYIGDD 322
            +G++LF G+L  +C +  P +              +  + TF N  M+    ++   GD+
Sbjct: 1749 LGVELF-GDL--ECDETHPCEG-------------LGRHATFRNFGMAFLTLFRVSTGDN 1792

Query: 323  SHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 382
             +  + D  +D            C +   C     +P Y + SF                
Sbjct: 1793 WNGIMKDTLRD------------CDQESTCYNTVISPIY-FVSF---------------- 1823

Query: 383  DYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKE 442
                                     +    F LVN+++AV+    EE N+   EEAE  E
Sbjct: 1824 -------------------------VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LE 1857

Query: 443  AEFQQMLEQLKKQ 455
            AE +  ++ L  Q
Sbjct: 1858 AELELEMKTLSPQ 1870



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 46/159 (28%), Positives = 71/159 (44%), Gaps = 15/159 (9%)

Query: 1528 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL--- 1580
            F+   M++I LN VT+ +    E          +L   +      F  E V+K+V+L   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1581 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1639
             +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195

Query: 1640 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1678
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 931 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 988
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 23/116 (19%), Positives = 46/116 (39%), Gaps = 25/116 (21%)

Query: 1676 NFAYVKKEAGIDDMF----NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1731
            N  Y    AG  + F    NF+  G + I +FQ+ T  GW  ++  ++++          
Sbjct: 317  NQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------- 366

Query: 1732 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1787
                       +      +F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 367  -----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
            isoform 7 [Homo sapiens]
          Length = 2298

 Score =  333 bits (853), Expect = 1e-90
 Identities = 199/609 (32%), Positives = 338/609 (55%), Gaps = 43/609 (7%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1255
            R  C+ I+ H  F+  ++ +I L+   +A E   I+     +  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1256 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANAL---GYSELGAIKSLRTLRA 1308
             +K VA G+    Q Y  ++W  LD L+V +S++ ++ + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1422

Query: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
            T N      + N SDC       RW   K NFDN+G   ++L  +A+  GW+DIMY  +D
Sbjct: 1423 TRN------ITNKSDCAEASY--RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474

Query: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1488
            +  V  QP+   N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRRE 1533

Query: 1489 QKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVT 1542
            +K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN+VT
Sbjct: 1534 EKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVT 1593

Query: 1543 MMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSI 1601
            M +E   Q + +   L   N +F V+F  E V KLV+     +F   WN  D  +V+LSI
Sbjct: 1594 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1653

Query: 1602 VGMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG 1659
            +G+ L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + N+G
Sbjct: 1654 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1713

Query: 1660 LLLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGL 1714
            LL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W+G+
Sbjct: 1714 LLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGI 1773

Query: 1715 LAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1774
            +   L     DCD ++          C N  +   +FVS+++ +  V+VN+ IAV++++ 
Sbjct: 1774 MKDTLR----DCDQES---------TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL 1820

Query: 1775 SVATEESAE 1783
              + +E+ E
Sbjct: 1821 EESNKEAKE 1829



 Score =  140 bits (354), Expect = 1e-32
 Identities = 78/247 (31%), Positives = 139/247 (56%), Gaps = 7/247 (2%)

Query: 746 WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 805
           W  +      IV   +    I I I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 806 EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 865
           EM+LK++   P+ Y +  +NIFDG+IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 866 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 924
           P L   + ++  ++  +    ++L + +FIF+++GM LFG  +        D  TLP R 
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERDGDTLPDRK 904

Query: 925 HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 983
           + +    + + VF++L  E W + +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAIL 963

Query: 984 LSSFSSD 990
           +  F ++
Sbjct: 964 VEGFQAE 970



 Score =  122 bits (307), Expect = 3e-27
 Identities = 97/377 (25%), Positives = 171/377 (45%), Gaps = 48/377 (12%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + +  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF +++   +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDS 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C        
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 286 AFETNTTSYFNGTMDSNGTFV------NVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGN 339
               +   Y+    +    F+      N   S  +     GD        G   P  CG 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGD-------GGGGPP--CGL 300

Query: 340 GSDAGQCPEGYICV---------KAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLY 389
             +A        CV          AG  NP  G  +FD   +A++++F+++T + W ++ 
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 390 QLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 449
              + A      I+F+L+I +GSF+++NL L V+A  +          +E K+ E Q M 
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SETKQRESQLMR 410

Query: 450 EQLKKQQEEAQAVAAAS 466
           EQ  +    A  +A+ S
Sbjct: 411 EQRVRFLSNASTLASFS 427



 Score =  113 bits (282), Expect = 2e-24
 Identities = 148/690 (21%), Positives = 278/690 (40%), Gaps = 144/690 (20%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 425  MAYEEQNQATLEEAEQK----------EAEFQQMLEQLKKQQEEAQAV-------AAASA 467
              ++ +  A   E+E            + +    L  L +  E  +++        AA+ 
Sbjct: 965  EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024

Query: 468  ASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSE 527
             S   S   GLGE L  +S  +  SS SA+       K         ++       P S 
Sbjct: 1025 MSLPKSTSTGLGEALGPASRRTS-SSGSAEPGAAHEMKSPPSARSSPHS-------PWSA 1076

Query: 528  SEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDV 587
            +     R S   S+        +      +SLLS                    G  ++ 
Sbjct: 1077 ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLS--------------------GEGQES 1116

Query: 588  GSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGL----PANGK 643
              E + +++E ++   S+ R       HR    R +  S     +  VPGL       G 
Sbjct: 1117 QDEEESSEEERASPAGSDHR-------HRGSLEREAKSSFDLPDTLQVPGLHRTASGRGS 1169

Query: 644  MHSTVDCNGVVSLVGGPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQ 703
                 DCNG            S +G+L           R  R     +  +  +D     
Sbjct: 1170 ASEHQDCNG-----------KSASGRL----------ARALRPDDPPLDGDDADDEGNLS 1208

Query: 704  RAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWL-----KVKHLVNLIVM 758
            +   + + +          R + P C        L  D   A++     + + L + I+ 
Sbjct: 1209 KGERVRAWI----------RARLPACC-------LERDSWSAYIFPPQSRFRLLCHRIIT 1251

Query: 759  DPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMVLKIIAMD 815
                D  + + I LN + +AME  P  +  S+    LT+ N +FT +F AEM +K++A+ 
Sbjct: 1252 HKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALG 1310

Query: 816  PYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLLRVFKLAK 863
              +    Y +  WN+ DG++V +S++++ +S V          L VLR  R LR  ++  
Sbjct: 1311 WCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVIS 1370

Query: 864  SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECVCKIND----- 917
                L ++++ + +S+  +GN+ ++      IF ++G+QLF GK +   VC+  D     
Sbjct: 1371 RAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF---VCQGEDTRNIT 1427

Query: 918  ---DCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG---------Q 957
               DC     RW  H  +F      L+   VL  +  W++ M+D ++  G          
Sbjct: 1428 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1487

Query: 958  TMCLIVFMLVMVIGNLVVLNLFLALLLSSF 987
               L+ F+  ++I    VLN+F+ +++ +F
Sbjct: 1488 PWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score =  110 bits (274), Expect = 2e-23
 Identities = 79/266 (29%), Positives = 131/266 (49%), Gaps = 24/266 (9%)

Query: 752  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 811
            LV+ +    ++DL IT  I LN + MAMEHY   +     L + N +FT IF  E V K+
Sbjct: 1569 LVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKL 1628

Query: 812  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKL 861
            +A     +FQ+ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 1629 VAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKL 1688

Query: 862  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 921
             K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C  
Sbjct: 1689 LKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEG 1744

Query: 922  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVA---GQTMCLIVFMLVMVIG 971
               H    +F  +FL +FRV  G+ W     +T+ DC + +      +  I F+  ++  
Sbjct: 1745 LGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1804

Query: 972  NLVVLNLFLALLLSSFSSDNLAATDD 997
              V++N+ +A+L+      N  A ++
Sbjct: 1805 QFVLVNVVIAVLMKHLEESNKEAKEE 1830



 Score =  105 bits (262), Expect = 4e-22
 Identities = 87/393 (22%), Positives = 163/393 (41%), Gaps = 90/393 (22%)

Query: 109  YILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + +  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 272  NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331
                                                                 F+V  G+
Sbjct: 1414 K----------------------------------------------------FFVCQGE 1421

Query: 332  KDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQL 391
             D     N SD  +    ++  K      Y +   D    A +SLF L ++D W ++   
Sbjct: 1422 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 392  TLRAAG----------KTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ-ATLEEAEQ 440
             L A G             +++F+  + + +F+++N+ + VV   + +  Q    EEA +
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531

Query: 441  KEAEFQQMLEQLKKQQEEAQAVAAASAASRDFS 473
            +E +  + LE+ ++ +E+  A A       D+S
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1564



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 41/283 (14%)

Query: 1192 WWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1251
            W  +  T   IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT +F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786

Query: 1252 ILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRP 1311
             LEMLLK + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R 
Sbjct: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRV 841

Query: 1312 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGN 1371
            L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF          
Sbjct: 842  LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA--------- 892

Query: 1372 MFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1431
                 D + L D             + NFD++    + + Q+ T + W  ++Y  + S  
Sbjct: 893  --SERDGDTLPD-------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST- 936

Query: 1432 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1474
                     + +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 937  ---------SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 91.3 bits (225), Expect = 9e-18
 Identities = 61/174 (35%), Positives = 96/174 (55%), Gaps = 19/174 (10%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1251
            R  C   V + WFE   + +ILL+   L      EDI  + ++  + +  + D +F + F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128

Query: 1252 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYS---ELGAIKSLRT 1305
             +EM++K VA   +G + Y  + W  LDF IV       +A  L YS   +  +  ++RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1306 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235



 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 71/273 (26%), Positives = 129/273 (47%), Gaps = 35/273 (12%)

Query: 1523 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1582
            V  + F   IMI I +N ++M +E  +Q + +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1583 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1641
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL R+   L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPAL 851

Query: 1642 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS----NFAYVKKEAGIDDMFNFETFGN 1697
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1698 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1757
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1758 SFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1790
               V+ N+ +A+++E F  A  ++ +  SE DF
Sbjct: 951  GNYVLFNLLVAILVEGFQ-AEGDANKSESEPDF 982



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 35/104 (33%), Positives = 61/104 (58%), Gaps = 13/104 (12%)

Query: 1398 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1457
            +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1458 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1501
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 47/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  VIV+  V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/175 (26%), Positives = 88/175 (50%), Gaps = 11/175 (6%)

Query: 757 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKII 812
           V +P+ +    + I+LN + + M    E      Q   +L   +      F  EMV+K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 813 AMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWPT 867
           A+  +    Y  + WN  D  IV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 868 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP 922
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+    +   C + ++ +LP
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN-RCFLPENFSLP 250



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 68/313 (21%), Positives = 130/313 (41%), Gaps = 87/313 (27%)

Query: 155  KNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA 214
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   V+A
Sbjct: 1610 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1665

Query: 215  -----------LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 263
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1666 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1725

Query: 264  IGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFN-WKDYIGDD 322
            +G++LF G+L  +C +  P +              +  + TF N  M+    ++   GD+
Sbjct: 1726 LGVELF-GDL--ECDETHPCEG-------------LGRHATFRNFGMAFLTLFRVSTGDN 1769

Query: 323  SHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 382
             +  + D  +D            C +   C     +P Y + SF                
Sbjct: 1770 WNGIMKDTLRD------------CDQESTCYNTVISPIY-FVSF---------------- 1800

Query: 383  DYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKE 442
                                     +    F LVN+++AV+    EE N+   EEAE  E
Sbjct: 1801 -------------------------VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LE 1834

Query: 443  AEFQQMLEQLKKQ 455
            AE +  ++ L  Q
Sbjct: 1835 AELELEMKTLSPQ 1847



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 46/159 (28%), Positives = 71/159 (44%), Gaps = 15/159 (9%)

Query: 1528 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL--- 1580
            F+   M++I LN VT+ +    E          +L   +      F  E V+K+V+L   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1581 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1639
             +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195

Query: 1640 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1678
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 931 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 988
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 23/116 (19%), Positives = 46/116 (39%), Gaps = 25/116 (21%)

Query: 1676 NFAYVKKEAGIDDMF----NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1731
            N  Y    AG  + F    NF+  G + I +FQ+ T  GW  ++  ++++          
Sbjct: 317  NQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------- 366

Query: 1732 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1787
                       +      +F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 367  -----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
            isoform 9 [Homo sapiens]
          Length = 2273

 Score =  333 bits (853), Expect = 1e-90
 Identities = 199/609 (32%), Positives = 338/609 (55%), Gaps = 43/609 (7%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1255
            R  C+ I+ H  F+  ++ +I L+   +A E   I+     +  L  ++ +FT +F+ EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325

Query: 1256 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANAL---GYSELGAIKSLRTLRA 1308
             +K VA G+    Q Y  ++W  LD L+V +S++ ++ + +   G   LG ++ LR LR 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGED 1445

Query: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
            T N      + N SDC       RW   K NFDN+G   ++L  +A+  GW+DIMY  +D
Sbjct: 1446 TRN------ITNKSDCAEASY--RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1497

Query: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1488
            +  V  QP+   N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1498 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RRRE 1556

Query: 1489 QKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVT 1542
            +K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN+VT
Sbjct: 1557 EKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVT 1616

Query: 1543 MMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSI 1601
            M +E   Q + +   L   N +F V+F  E V KLV+     +F   WN  D  +V+LSI
Sbjct: 1617 MAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI 1676

Query: 1602 VGMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG 1659
            +G+ L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + N+G
Sbjct: 1677 MGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLG 1736

Query: 1660 LLLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGL 1714
            LL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W+G+
Sbjct: 1737 LLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGI 1796

Query: 1715 LAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1774
            +   L     DCD ++          C N  +   +FVS+++ +  V+VN+ IAV++++ 
Sbjct: 1797 MKDTLR----DCDQES---------TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL 1843

Query: 1775 SVATEESAE 1783
              + +E+ E
Sbjct: 1844 EESNKEAKE 1852



 Score =  145 bits (365), Expect = 5e-34
 Identities = 81/266 (30%), Positives = 150/266 (56%), Gaps = 8/266 (3%)

Query: 746  WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 805
            W  +      IV   +    I I I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 806  EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 865
            EM+LK++   P+ Y +  +NIFDG+IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 866  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 924
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  +        D  TLP R 
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERDGDTLPDRK 904

Query: 925  HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 983
            + +    + + VF++L  E W + +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAIL 963

Query: 984  LSSFSSDNLAATDD-DNEMNNLQIAV 1008
            +  F ++ ++  +D   +++ +Q+ V
Sbjct: 964  VEGFQAEEISKREDASGQLSCIQLPV 989



 Score =  122 bits (307), Expect = 3e-27
 Identities = 97/377 (25%), Positives = 171/377 (45%), Gaps = 48/377 (12%)

Query: 118 RKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPD----------WTKNVEYTFTGIYTF 167
           R   ++ + +  F  + M  IL NCV + +  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 168 ESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS--ALRTFRVLRALK 225
           E ++K++A G   +   +L D WN LDF +++   +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDS 285
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C        
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSL 249

Query: 286 AFETNTTSYFNGTMDSNGTFV------NVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGN 339
               +   Y+    +    F+      N   S  +     GD        G   P  CG 
Sbjct: 250 PLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGD-------GGGGPP--CGL 300

Query: 340 GSDAGQCPEGYICV---------KAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLY 389
             +A        CV          AG  NP  G  +FD   +A++++F+++T + W ++ 
Sbjct: 301 DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 390 QLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 449
              + A      I+F+L+I +GSF+++NL L V+A  +          +E K+ E Q M 
Sbjct: 361 YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SETKQRESQLMR 410

Query: 450 EQLKKQQEEAQAVAAAS 466
           EQ  +    A  +A+ S
Sbjct: 411 EQRVRFLSNASTLASFS 427



 Score =  111 bits (278), Expect = 6e-24
 Identities = 156/700 (22%), Positives = 287/700 (41%), Gaps = 141/700 (20%)

Query: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 425  MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLES 484
              ++ +     E +++++A  Q    QL    +   A  + S        + G G+  + 
Sbjct: 965  EGFQAE-----EISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKC 1019

Query: 485  SSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESED-------SVKRSSF 537
                  L+  S  E    RK       L  +      S PKS S         + +R+S 
Sbjct: 1020 ------LALVSLGEHPELRKSLLPP--LIIHTAATPMSLPKSTSTGLGEALGPASRRTSS 1071

Query: 538  LFSMDGNRLTSDKK----FCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDV------ 587
              S +       K       SPH    +   S ++ RR+S+ S+    GRA  +      
Sbjct: 1072 SGSAEPGAAHEMKSPPSARSSPHSPWSA--ASSWTSRRSSRNSL----GRAPSLKRRSPS 1125

Query: 588  --------GSENDFADDEHSTFEDSESRRDSLFVPHRH--GERRNSNVSQASMSSRMVPG 637
                    G   +  D+E S+ E+  S   S    HRH     R +  S     +  VPG
Sbjct: 1126 GERRSLLSGEGQESQDEEESSEEERASPAGS---DHRHRGSLEREAKSSFDLPDTLQVPG 1182

Query: 638  L----PANGKMHSTVDCNGVVSLVGGPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISM 693
            L       G      DCNG            S +G+L           R  R     +  
Sbjct: 1183 LHRTASGRGSASEHQDCNG-----------KSASGRL----------ARALRPDDPPLDG 1221

Query: 694  EMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWL-----K 748
            +  +D     +   + + +          R + P C        L  D   A++     +
Sbjct: 1222 DDADDEGNLSKGERVRAWI----------RARLPACC-------LERDSWSAYIFPPQSR 1264

Query: 749  VKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTA 805
             + L + I+     D  + + I LN + +AME  P  +  S+    LT+ N +FT +F A
Sbjct: 1265 FRLLCHRIITHKMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAVFLA 1323

Query: 806  EMVLKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSF 853
            EM +K++A+   +    Y +  WN+ DG++V +S++++ +S V          L VLR  
Sbjct: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383

Query: 854  RLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 912
            R LR  ++      L ++++ + +S+  +GN+ ++      IF ++G+QLF GK +   V
Sbjct: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF---V 1440

Query: 913  CKIND--------DCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG 956
            C+  D        DC     RW  H  +F      L+   VL  +  W++ M+D ++  G
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVG 1500

Query: 957  ---------QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 987
                         L+ F+  ++I    VLN+F+ +++ +F
Sbjct: 1501 VDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  110 bits (274), Expect = 2e-23
 Identities = 79/266 (29%), Positives = 131/266 (49%), Gaps = 24/266 (9%)

Query: 752  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 811
            LV+ +    ++DL IT  I LN + MAMEHY   +     L + N +FT IF  E V K+
Sbjct: 1592 LVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKL 1651

Query: 812  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKL 861
            +A     +FQ+ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 1652 VAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKL 1711

Query: 862  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 921
             K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C  
Sbjct: 1712 LKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEG 1767

Query: 922  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVA---GQTMCLIVFMLVMVIG 971
               H    +F  +FL +FRV  G+ W     +T+ DC + +      +  I F+  ++  
Sbjct: 1768 LGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTA 1827

Query: 972  NLVVLNLFLALLLSSFSSDNLAATDD 997
              V++N+ +A+L+      N  A ++
Sbjct: 1828 QFVLVNVVIAVLMKHLEESNKEAKEE 1853



 Score =  105 bits (262), Expect = 4e-22
 Identities = 87/393 (22%), Positives = 163/393 (41%), Gaps = 90/393 (22%)

Query: 109  YILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE--------YT 160
            YI  P +  R +  +I+ H +F  +++  I  NC+ + +  P     + E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 161  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGN 211
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 212  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 272  NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331
                                                                 F+V  G+
Sbjct: 1437 K----------------------------------------------------FFVCQGE 1444

Query: 332  KDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQL 391
             D     N SD  +    ++  K      Y +   D    A +SLF L ++D W ++   
Sbjct: 1445 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1494

Query: 392  TLRAAG----------KTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ-ATLEEAEQ 440
             L A G             +++F+  + + +F+++N+ + VV   + +  Q    EEA +
Sbjct: 1495 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1554

Query: 441  KEAEFQQMLEQLKKQQEEAQAVAAASAASRDFS 473
            +E +  + LE+ ++ +E+  A A       D+S
Sbjct: 1555 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1587



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 70/284 (24%), Positives = 133/284 (46%), Gaps = 41/284 (14%)

Query: 1192 WWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1251
            W  +  T   IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT +F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786

Query: 1252 ILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRP 1311
             LEMLLK + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R 
Sbjct: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRV 841

Query: 1312 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGN 1371
            L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF          
Sbjct: 842  LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFA--------- 892

Query: 1372 MFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1431
                 D + L D             + NFD++    + + Q+ T + W  ++Y  + S  
Sbjct: 893  --SERDGDTLPD-------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST- 936

Query: 1432 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1475
                     + +  LYF+  + FG++   NL + ++++ F  ++
Sbjct: 937  ---------SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971



 Score = 91.3 bits (225), Expect = 9e-18
 Identities = 61/174 (35%), Positives = 96/174 (55%), Gaps = 19/174 (10%)

Query: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1251
            R  C   V + WFE   + +ILL+   L      EDI  + ++  + +  + D +F + F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128

Query: 1252 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYS---ELGAIKSLRT 1305
             +EM++K VA   +G + Y  + W  LDF IV       +A  L YS   +  +  ++RT
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAVRT 181

Query: 1306 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 182  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 68/269 (25%), Positives = 123/269 (45%), Gaps = 34/269 (12%)

Query: 1523 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1582
            V  + F   IMI I +N ++M +E  +Q + +T  L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1583 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1641
            + Y    +NIFD V+V++S+      E++ +     ++ R  RL    R+L+L++    +
Sbjct: 800  FGYIKNPYNIFDGVIVVISV-----WEIVGQQGGGLSVLRTFRLM---RVLKLVRFLPAL 851

Query: 1642 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKKEAGIDDMFNFETFGN 1697
            +  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++   
Sbjct: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911

Query: 1698 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1757
            +++ +FQI T   W+ +L                       G     S    +F++ +  
Sbjct: 912  AIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIALMTF 950

Query: 1758 SFLVVVNMYIAVILENFSVATEESAEPLS 1786
               V+ N+ +A+++E F        E  S
Sbjct: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 35/104 (33%), Positives = 61/104 (58%), Gaps = 13/104 (12%)

Query: 1398 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1457
            +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSF 384

Query: 1458 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1501
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 47/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234
           G     F ++++P+N  D  VIV+  V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/175 (26%), Positives = 88/175 (50%), Gaps = 11/175 (6%)

Query: 757 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKII 812
           V +P+ +    + I+LN + + M    E      Q   +L   +      F  EMV+K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 813 AMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWPT 867
           A+  +    Y  + WN  D  IV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 868 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP 922
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+    +   C + ++ +LP
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN-RCFLPENFSLP 250



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 68/313 (21%), Positives = 130/313 (41%), Gaps = 87/313 (27%)

Query: 155  KNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA 214
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   V+A
Sbjct: 1633 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1688

Query: 215  -----------LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 263
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1689 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1748

Query: 264  IGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFN-WKDYIGDD 322
            +G++LF G+L  +C +  P +              +  + TF N  M+    ++   GD+
Sbjct: 1749 LGVELF-GDL--ECDETHPCEG-------------LGRHATFRNFGMAFLTLFRVSTGDN 1792

Query: 323  SHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 382
             +  + D  +D            C +   C     +P Y + SF                
Sbjct: 1793 WNGIMKDTLRD------------CDQESTCYNTVISPIY-FVSF---------------- 1823

Query: 383  DYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKE 442
                                     +    F LVN+++AV+    EE N+   EEAE  E
Sbjct: 1824 -------------------------VLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LE 1857

Query: 443  AEFQQMLEQLKKQ 455
            AE +  ++ L  Q
Sbjct: 1858 AELELEMKTLSPQ 1870



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 46/159 (28%), Positives = 71/159 (44%), Gaps = 15/159 (9%)

Query: 1528 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL--- 1580
            F+   M++I LN VT+ +    E          +L   +      F  E V+K+V+L   
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1581 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1639
             +  Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195

Query: 1640 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1678
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 931 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 988
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 342 YAWIAIFQVITLEGWVDIMYFVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 23/116 (19%), Positives = 46/116 (39%), Gaps = 25/116 (21%)

Query: 1676 NFAYVKKEAGIDDMF----NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1731
            N  Y    AG  + F    NF+  G + I +FQ+ T  GW  ++  ++++          
Sbjct: 317  NQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------- 366

Query: 1732 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1787
                       +      +F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 367  -----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,251,287
Number of Sequences: 37866
Number of extensions: 3113099
Number of successful extensions: 19326
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 136
Number of HSP's that attempted gapping in prelim test: 14409
Number of HSP's gapped (non-prelim): 2227
length of query: 2000
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1883
effective length of database: 13,817,196
effective search space: 26017780068
effective search space used: 26017780068
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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