Search of human proteins with 41327730

Search of human proteins with 41327730

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41327730 calponin 2 isoform b [Homo sapiens]
         (270 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41327730 calponin 2 isoform b [Homo sapiens]                       562   e-160
gi|4758018 calponin 2 isoform a [Homo sapiens]                        543   e-155
gi|4502923 calponin 3 [Homo sapiens]                                  326   1e-89
gi|21361120 calponin 1, basic, smooth muscle [Homo sapiens]           306   9e-84
gi|4507357 transgelin 2 [Homo sapiens]                                114   9e-26
gi|56549135 transgelin 3 [Homo sapiens]                               114   1e-25
gi|56549139 transgelin 3 [Homo sapiens]                               114   1e-25
gi|56549137 transgelin 3 [Homo sapiens]                               114   1e-25
gi|48255907 transgelin [Homo sapiens]                                 102   5e-22
gi|48255905 transgelin [Homo sapiens]                                 102   5e-22
gi|163310745 LIM and calponin homology domains 1 isoform c [Homo...    68   1e-11
gi|163310743 LIM and calponin homology domains 1 isoform b [Homo...    68   1e-11
gi|163310741 LIM and calponin homology domains 1 isoform a [Homo...    68   1e-11
gi|33598968 LIM domain only 7 isoform 1 [Homo sapiens]                 57   2e-08
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo...    54   2e-07
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo...    49   6e-06
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ...    44   2e-04
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom...    43   3e-04
gi|30181233 leucine-rich repeats and calponin homology (CH) doma...    42   4e-04
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]     42   6e-04
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...    42   6e-04
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...    42   6e-04
gi|33859670 leucine-rich repeats and calponin homology (CH) doma...    39   0.005
gi|154091020 leucine-rich repeats and calponin homology (CH) dom...    38   0.011
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom...    37   0.024
gi|14249428 leucine-rich repeats and calponin homology (CH) doma...    35   0.069
gi|28372563 growth arrest-specific 2 like 3 [Homo sapiens]             33   0.20 
gi|17017974 wingless-type MMTV integration site family, member 1...    32   0.58 
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]           30   2.2  
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]           30   2.2  

>gi|41327730 calponin 2 isoform b [Homo sapiens]
          Length = 270

 Score =  562 bits (1449), Expect = e-160
 Identities = 270/270 (100%), Positives = 270/270 (100%)

Query: 1   MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL 60
           MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL
Sbjct: 1   MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL 60

Query: 61  CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV 120
           CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV
Sbjct: 61  CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV 120

Query: 121 QVSLLALAGKMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQV 180
           QVSLLALAGKMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQV
Sbjct: 121 QVSLLALAGKMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQV 180

Query: 181 GMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTV 240
           GMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTV
Sbjct: 181 GMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTV 240

Query: 241 ADGAPSGTGDCPDPGEVPEYPPYYQEEAGY 270
           ADGAPSGTGDCPDPGEVPEYPPYYQEEAGY
Sbjct: 241 ADGAPSGTGDCPDPGEVPEYPPYYQEEAGY 270


>gi|4758018 calponin 2 isoform a [Homo sapiens]
          Length = 309

 Score =  543 bits (1399), Expect = e-155
 Identities = 270/309 (87%), Positives = 270/309 (87%), Gaps = 39/309 (12%)

Query: 1   MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL 60
           MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL
Sbjct: 1   MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL 60

Query: 61  CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV 120
           CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV
Sbjct: 61  CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV 120

Query: 121 QVSLLALAGK---------------------------------------MGTNKCASQSG 141
           QVSLLALAGK                                       MGTNKCASQSG
Sbjct: 121 QVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSG 180

Query: 142 MTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKC 201
           MTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKC
Sbjct: 181 MTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKC 240

Query: 202 DNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTVADGAPSGTGDCPDPGEVPEYP 261
           DNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTVADGAPSGTGDCPDPGEVPEYP
Sbjct: 241 DNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTVADGAPSGTGDCPDPGEVPEYP 300

Query: 262 PYYQEEAGY 270
           PYYQEEAGY
Sbjct: 301 PYYQEEAGY 309


>gi|4502923 calponin 3 [Homo sapiens]
          Length = 329

 Score =  326 bits (835), Expect = 1e-89
 Identities = 177/310 (57%), Positives = 202/310 (65%), Gaps = 46/310 (14%)

Query: 4   TQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTL 63
           T FNKGPSYGLSAEVKN++ SKYD Q E +LR WIE +TG+SIGP+FQ GLKDG ILC L
Sbjct: 2   THFNKGPSYGLSAEVKNKIASKYDHQAEEDLRNWIEEVTGMSIGPNFQLGLKDGIILCEL 61

Query: 64  MNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVS 123
           +NKLQPGSV K+N S  NW QLEN+ NFIKA+ +YGM P D+FEANDLFE+GNMTQVQ +
Sbjct: 62  INKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTT 121

Query: 124 LLALAG---------------------------------------KMGTNKCASQSGMTA 144
           L+ALAG                                       +MGTNKCASQ+GMTA
Sbjct: 122 LVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTA 181

Query: 145 YGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKCDNS 204
           YGTRRHLYDPK     P D +TISLQMGTNK ASQ GM APGTRR IYD KL     DNS
Sbjct: 182 YGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNS 241

Query: 205 SMSLQMGYTQGANQSG-QVFGLGRQIYDPKYC--PQGTVADGAPSGTG----DCPDPGEV 257
           ++SLQMG  + A+Q G  V+GLGRQ+YDPKYC  P   V      GTG    +  D    
Sbjct: 242 TISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQ 301

Query: 258 PEYPPYYQEE 267
            EYP  Y  E
Sbjct: 302 AEYPDEYHGE 311


>gi|21361120 calponin 1, basic, smooth muscle [Homo sapiens]
          Length = 297

 Score =  306 bits (785), Expect = 9e-84
 Identities = 160/273 (58%), Positives = 186/273 (68%), Gaps = 38/273 (13%)

Query: 1   MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL 60
           MSS  FN+GP+YGLSAEVKN+L  KYD Q+E ELR WIEG+TG  IG +F  GLKDG IL
Sbjct: 1   MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIIL 60

Query: 61  CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV 120
           C  +NKLQPGSV KIN S QNWHQLEN+ NFIKA+  YG+ P D+FEANDLFE+ N TQV
Sbjct: 61  CEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQV 120

Query: 121 QVSLLALAG-------------------------------------KMGTNKCASQSGMT 143
           Q +LLALA                                      +MGTNK ASQ GMT
Sbjct: 121 QSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMT 180

Query: 144 AYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKCDN 203
           AYGTRRHLYDPK     P+D +TISLQMGTNK ASQ GMTAPGT+R I++  LG + CD 
Sbjct: 181 AYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDT 240

Query: 204 SSMSLQMGYTQGANQSGQ-VFGLGRQIYDPKYC 235
            ++SLQMG  +GA+Q G  V+GL RQ+YDPKYC
Sbjct: 241 LNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYC 273



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 22/50 (44%), Positives = 30/50 (60%), Gaps = 1/50 (2%)

Query: 111 LFESGNMTQVQVSLLALAGKMGTNKCASQSGMTAYGTRRHLYDPKNHILP 160
           +FE G +       L ++ +MG+NK ASQ GMT YG  R +YDPK  + P
Sbjct: 228 IFEPG-LGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTP 276


>gi|4507357 transgelin 2 [Homo sapiens]
          Length = 199

 Score =  114 bits (285), Expect = 9e-26
 Identities = 73/196 (37%), Positives = 102/196 (52%), Gaps = 11/196 (5%)

Query: 7   NKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIG------PDFQKGLKDGTIL 60
           N+GP+YGLS EV+ ++  +YD   E  L  WI       +G       +FQ  LKDGT+L
Sbjct: 3   NRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVL 62

Query: 61  CTLMNKLQP---GSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNM 117
           C L+N L P     V KI  S   + Q+E +S F++A   YG+N  D+F+  DL+E  NM
Sbjct: 63  CELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNM 122

Query: 118 TQVQVSLLALAGKMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDH--STISLQMGTNK 175
             VQ +L+ L G          SG   +  ++   +P+N     +    + I LQMGTN+
Sbjct: 123 ACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGTNR 182

Query: 176 CASQVGMTAPGTRRHI 191
            ASQ GMT  G  R I
Sbjct: 183 GASQAGMTGYGMPRQI 198


>gi|56549135 transgelin 3 [Homo sapiens]
          Length = 199

 Score =  114 bits (284), Expect = 1e-25
 Identities = 74/196 (37%), Positives = 104/196 (53%), Gaps = 11/196 (5%)

Query: 7   NKGPSYGLSAEVKNRLLSKYDPQKEAELRTWI-----EGLTGLSIG-PDFQKGLKDGTIL 60
           N+GPSYGLS EV+ ++  KYD   E +L  WI     E +     G   FQK L DGT+L
Sbjct: 3   NRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGTVL 62

Query: 61  CTLMNKLQPGS---VPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNM 117
           C L+N L P     +PKI+ S   + Q+E +S F+KA  +YG+   D+F+  DL+E  +M
Sbjct: 63  CKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAETYGVRTTDIFQTVDLWEGKDM 122

Query: 118 TQVQVSLLALAGKMGTNKCASQSGMTAYGTRRHLYDPKNHILPPM--DHSTISLQMGTNK 175
             VQ +L+AL     T       G  ++  R+   + +      +    + I LQMG+NK
Sbjct: 123 AAVQRTLMALGSVAVTKDDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGSNK 182

Query: 176 CASQVGMTAPGTRRHI 191
            ASQ GMT  G  R I
Sbjct: 183 GASQAGMTGYGMPRQI 198


>gi|56549139 transgelin 3 [Homo sapiens]
          Length = 199

 Score =  114 bits (284), Expect = 1e-25
 Identities = 74/196 (37%), Positives = 104/196 (53%), Gaps = 11/196 (5%)

Query: 7   NKGPSYGLSAEVKNRLLSKYDPQKEAELRTWI-----EGLTGLSIG-PDFQKGLKDGTIL 60
           N+GPSYGLS EV+ ++  KYD   E +L  WI     E +     G   FQK L DGT+L
Sbjct: 3   NRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGTVL 62

Query: 61  CTLMNKLQPGS---VPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNM 117
           C L+N L P     +PKI+ S   + Q+E +S F+KA  +YG+   D+F+  DL+E  +M
Sbjct: 63  CKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAETYGVRTTDIFQTVDLWEGKDM 122

Query: 118 TQVQVSLLALAGKMGTNKCASQSGMTAYGTRRHLYDPKNHILPPM--DHSTISLQMGTNK 175
             VQ +L+AL     T       G  ++  R+   + +      +    + I LQMG+NK
Sbjct: 123 AAVQRTLMALGSVAVTKDDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGSNK 182

Query: 176 CASQVGMTAPGTRRHI 191
            ASQ GMT  G  R I
Sbjct: 183 GASQAGMTGYGMPRQI 198


>gi|56549137 transgelin 3 [Homo sapiens]
          Length = 199

 Score =  114 bits (284), Expect = 1e-25
 Identities = 74/196 (37%), Positives = 104/196 (53%), Gaps = 11/196 (5%)

Query: 7   NKGPSYGLSAEVKNRLLSKYDPQKEAELRTWI-----EGLTGLSIG-PDFQKGLKDGTIL 60
           N+GPSYGLS EV+ ++  KYD   E +L  WI     E +     G   FQK L DGT+L
Sbjct: 3   NRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGTVL 62

Query: 61  CTLMNKLQPGS---VPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNM 117
           C L+N L P     +PKI+ S   + Q+E +S F+KA  +YG+   D+F+  DL+E  +M
Sbjct: 63  CKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAETYGVRTTDIFQTVDLWEGKDM 122

Query: 118 TQVQVSLLALAGKMGTNKCASQSGMTAYGTRRHLYDPKNHILPPM--DHSTISLQMGTNK 175
             VQ +L+AL     T       G  ++  R+   + +      +    + I LQMG+NK
Sbjct: 123 AAVQRTLMALGSVAVTKDDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGSNK 182

Query: 176 CASQVGMTAPGTRRHI 191
            ASQ GMT  G  R I
Sbjct: 183 GASQAGMTGYGMPRQI 198


>gi|48255907 transgelin [Homo sapiens]
          Length = 201

 Score =  102 bits (253), Expect = 5e-22
 Identities = 76/198 (38%), Positives = 103/198 (52%), Gaps = 14/198 (7%)

Query: 7   NKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIG-PD-----FQKGLKDGTIL 60
           NKGPSYG+S EV++++  KYD + E  L  WI    G  +G PD     FQ  LK+G IL
Sbjct: 3   NKGPSYGMSREVQSKIEKKYDEELEERLVEWIIVQCGPDVGRPDRGRLGFQVWLKNGVIL 62

Query: 61  CTLMNKLQP-GSVP-KI--NRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGN 116
             L+N L P GS P K+  N     + Q+E ++ F+KA   YG+   D+F+  DLFE  +
Sbjct: 63  SKLVNSLYPDGSKPVKVPENPPSMVFKQMEQVAQFLKAAEDYGVIKTDMFQTVDLFEGKD 122

Query: 117 MTQVQVSLLALAGKMGTNKCASQSGMTAYGTRR---HLYDPKNHILPPMDHSTISLQMGT 173
           M  VQ +L+AL     T       G   +  ++   H  +     L    H  I LQMG+
Sbjct: 123 MAAVQRTLMALGSLAVTKNDGHYRGDPNWFMKKAQEHKREFTESQLQEGKH-VIGLQMGS 181

Query: 174 NKCASQVGMTAPGTRRHI 191
           N+ ASQ GMT  G  R I
Sbjct: 182 NRGASQAGMTGYGRPRQI 199


>gi|48255905 transgelin [Homo sapiens]
          Length = 201

 Score =  102 bits (253), Expect = 5e-22
 Identities = 76/198 (38%), Positives = 103/198 (52%), Gaps = 14/198 (7%)

Query: 7   NKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIG-PD-----FQKGLKDGTIL 60
           NKGPSYG+S EV++++  KYD + E  L  WI    G  +G PD     FQ  LK+G IL
Sbjct: 3   NKGPSYGMSREVQSKIEKKYDEELEERLVEWIIVQCGPDVGRPDRGRLGFQVWLKNGVIL 62

Query: 61  CTLMNKLQP-GSVP-KI--NRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGN 116
             L+N L P GS P K+  N     + Q+E ++ F+KA   YG+   D+F+  DLFE  +
Sbjct: 63  SKLVNSLYPDGSKPVKVPENPPSMVFKQMEQVAQFLKAAEDYGVIKTDMFQTVDLFEGKD 122

Query: 117 MTQVQVSLLALAGKMGTNKCASQSGMTAYGTRR---HLYDPKNHILPPMDHSTISLQMGT 173
           M  VQ +L+AL     T       G   +  ++   H  +     L    H  I LQMG+
Sbjct: 123 MAAVQRTLMALGSLAVTKNDGHYRGDPNWFMKKAQEHKREFTESQLQEGKH-VIGLQMGS 181

Query: 174 NKCASQVGMTAPGTRRHI 191
           N+ ASQ GMT  G  R I
Sbjct: 182 NRGASQAGMTGYGRPRQI 199


>gi|163310745 LIM and calponin homology domains 1 isoform c [Homo
           sapiens]
          Length = 1056

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 43/125 (34%), Positives = 65/125 (52%), Gaps = 15/125 (12%)

Query: 32  AELRTWIEGLTGLSIGP-DFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSN 90
           +E + WIE +TG S G  DF+ GL++G +LC L+N ++PG V KINR       L+N+  
Sbjct: 25  SEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLDNIIL 84

Query: 91  FIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKM------------GTNKCAS 138
           F++     G+    LF+ +DL ++ N  +V V  L  + K+              N C S
Sbjct: 85  FLRGCKELGLKESQLFDPSDLQDTSN--RVTVKSLDYSRKLKNVLVTIYWLGKAANSCTS 142

Query: 139 QSGMT 143
            SG T
Sbjct: 143 YSGTT 147


>gi|163310743 LIM and calponin homology domains 1 isoform b [Homo
           sapiens]
          Length = 1057

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 43/125 (34%), Positives = 65/125 (52%), Gaps = 15/125 (12%)

Query: 32  AELRTWIEGLTGLSIGP-DFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSN 90
           +E + WIE +TG S G  DF+ GL++G +LC L+N ++PG V KINR       L+N+  
Sbjct: 25  SEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLDNIIL 84

Query: 91  FIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKM------------GTNKCAS 138
           F++     G+    LF+ +DL ++ N  +V V  L  + K+              N C S
Sbjct: 85  FLRGCKELGLKESQLFDPSDLQDTSN--RVTVKSLDYSRKLKNVLVTIYWLGKAANSCTS 142

Query: 139 QSGMT 143
            SG T
Sbjct: 143 YSGTT 147


>gi|163310741 LIM and calponin homology domains 1 isoform a [Homo
           sapiens]
          Length = 1083

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 43/125 (34%), Positives = 65/125 (52%), Gaps = 15/125 (12%)

Query: 32  AELRTWIEGLTGLSIGP-DFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSN 90
           +E + WIE +TG S G  DF+ GL++G +LC L+N ++PG V KINR       L+N+  
Sbjct: 25  SEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLDNIIL 84

Query: 91  FIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKM------------GTNKCAS 138
           F++     G+    LF+ +DL ++ N  +V V  L  + K+              N C S
Sbjct: 85  FLRGCKELGLKESQLFDPSDLQDTSN--RVTVKSLDYSRKLKNVLVTIYWLGKAANSCTS 142

Query: 139 QSGMT 143
            SG T
Sbjct: 143 YSGTT 147


>gi|33598968 LIM domain only 7 isoform 1 [Homo sapiens]
          Length = 1349

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 28/73 (38%), Positives = 42/73 (57%)

Query: 49  DFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEA 108
           DF+  L++G +LC L+NKL+PG + KINR       L+N++ F+KA    G+    LF  
Sbjct: 86  DFRASLENGVLLCDLINKLKPGVIKKINRLSTPIAGLDNINVFLKACEQIGLKEAQLFHP 145

Query: 109 NDLFESGNMTQVQ 121
            DL +  N   V+
Sbjct: 146 GDLQDLSNRVTVK 158


>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
           sapiens]
          Length = 776

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 42/166 (25%), Positives = 80/166 (48%), Gaps = 18/166 (10%)

Query: 51  QKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQ-LENLSNFIKAMVSYGMNPVDLFEAN 109
           +  LK+G +LC L+N+L PGSV K     Q     + N+++F+K   +     V++F+ +
Sbjct: 32  KSSLKNGVVLCKLINRLMPGSVEKFCLDPQTEADCINNINDFLKGCATL---QVEIFDPD 88

Query: 110 DLFESGNMTQVQVSLLAL----AGKMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDHS 165
           DL+   N ++V  +LLA+      ++    C   S ++A  T +   +P+  +      S
Sbjct: 89  DLYSGVNFSKVLSTLLAVNKATEDQLSERPCGRSSSLSAANTSQ--TNPQGAV-----SS 141

Query: 166 TISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMG 211
           T+S   G  + +  V MT  G+ + I   +    + +   +S+  G
Sbjct: 142 TVS---GLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKG 184


>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
           sapiens]
          Length = 782

 Score = 48.5 bits (114), Expect = 6e-06
 Identities = 43/167 (25%), Positives = 75/167 (44%), Gaps = 17/167 (10%)

Query: 51  QKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMN-PVDLFEAN 109
           Q  LKDG +LC L+ +L PG++ K+    ++  + E LSN  + +   G +  ++ F+AN
Sbjct: 32  QASLKDGVVLCRLLERLLPGTIEKVYPEPRS--ESECLSNIREFLRGCGASLRLETFDAN 89

Query: 110 DLFESGNMTQVQVSLLALAGKMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDH-STIS 168
           DL++  N  +V  SL+ L      NK  +  G+   G+      P +H +   D   + S
Sbjct: 90  DLYQGQNFNKVLSSLVTL------NKVTADIGL---GSDSVCARPSSHRIKSFDSLGSQS 140

Query: 169 LQMGTNKCAS----QVGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMG 211
           L   T+K        + MT     + +   K    + +   +S   G
Sbjct: 141 LHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKG 187


>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 847

 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 30/110 (27%), Positives = 54/110 (49%), Gaps = 9/110 (8%)

Query: 49  DFQKGLKDGTILCTLMNKLQPGSVP----KINRSMQNWHQLENLSNFIKAMV-SYGMNPV 103
           D  + L+DG +LC L+N L+  S+      +   M  +  L+N+  F+ A   ++GM   
Sbjct: 32  DLAQTLRDGVLLCQLLNNLRAHSINLKEINLRPQMSQFLCLKNIRTFLTACCETFGMRKS 91

Query: 104 DLFEANDLFESGNMTQVQVSLLALAGKMGTNKCASQSGMTAYGTRRHLYD 153
           +LFEA DLF+  +  +V  +L     ++     A  +G+  + T   + D
Sbjct: 92  ELFEAFDLFDVRDFGKVIETL----SRLSRTPIALATGIRPFPTEESIND 137


>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
           sapiens]
          Length = 803

 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 42/186 (22%), Positives = 75/186 (40%), Gaps = 34/186 (18%)

Query: 51  QKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQ-LENLSNFIKA--------------- 94
           Q  LKDG +LC L+ +L PG++ K+    ++  + L N+  F++                
Sbjct: 32  QASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLELLFPPSQ 91

Query: 95  ----MVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKMGTNKCASQSGMTAYGTRRH 150
               +V+  +     F+ANDL++  N  +V  SL+ L      NK  +  G+   G+   
Sbjct: 92  PPQHLVTTILLSASTFDANDLYQGQNFNKVLSSLVTL------NKVTADIGL---GSDSV 142

Query: 151 LYDPKNHILPPMDH-STISLQMGTNKCAS----QVGMTAPGTRRHIYDTKLGTDKCDNSS 205
              P +H +   D   + SL   T+K        + MT     + +   K    + +   
Sbjct: 143 CARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDE 202

Query: 206 MSLQMG 211
           +S   G
Sbjct: 203 LSFSKG 208


>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
           containing 4 [Homo sapiens]
          Length = 683

 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 34/120 (28%), Positives = 56/120 (46%), Gaps = 9/120 (7%)

Query: 2   SSTQFNKGPSYGLSAEVKNRLLSKYDPQKE--AELRTWIEGLTGLSIGPDFQKGLKDGTI 59
           SS+Q   GPS   S  ++ R   +   +K+   +LR  +E      +  D  + L  G I
Sbjct: 511 SSSQSGSGPSSPDSV-LRPRRYPQVPDEKDLMTQLRQVLESRLQRPLPEDLAEALASGVI 569

Query: 60  LCTLMNKLQPGSVPKIN------RSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFE 113
           LC L N+L+P SVP I+        +      +N+ +F++A    G+   DL   +DL +
Sbjct: 570 LCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMGVPEADLCSPSDLLQ 629


>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 25/85 (29%), Positives = 45/85 (52%), Gaps = 5/85 (5%)

Query: 49  DFQKGLKDGTILCTLMNKLQPGSV----PKINRSMQNWHQLENLSNFIKAMV-SYGMNPV 103
           +  + L+DG +LC L+N L P ++      +   M  +  L+N+  F+      +G+   
Sbjct: 32  ELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRS 91

Query: 104 DLFEANDLFESGNMTQVQVSLLALA 128
           +LFEA DLF+  +  +V  +L AL+
Sbjct: 92  ELFEAFDLFDVQDFGKVIYTLSALS 116


>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 878

 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 28/101 (27%), Positives = 50/101 (49%), Gaps = 10/101 (9%)

Query: 49  DFQKGLKDGTILCTLMNKLQPGSVP----KINRSMQNWHQLENLSNFIKAM-VSYGMNPV 103
           D  + L+DG +LC L++ L PGS+          M  +  L+N+  F+K     +G+   
Sbjct: 32  DLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNS 91

Query: 104 DLFEANDLFESGNMTQV-----QVSLLALAGKMGTNKCASQ 139
           +LF+  DLF+  +  +V     ++SL ++A   G     S+
Sbjct: 92  ELFDPFDLFDVRDFGKVISAVSRLSLHSIAQNKGIRPFPSE 132


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 28/101 (27%), Positives = 50/101 (49%), Gaps = 10/101 (9%)

Query: 49  DFQKGLKDGTILCTLMNKLQPGSVP----KINRSMQNWHQLENLSNFIKAM-VSYGMNPV 103
           D  + L+DG +LC L++ L PGS+          M  +  L+N+  F+K     +G+   
Sbjct: 32  DLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNS 91

Query: 104 DLFEANDLFESGNMTQV-----QVSLLALAGKMGTNKCASQ 139
           +LF+  DLF+  +  +V     ++SL ++A   G     S+
Sbjct: 92  ELFDPFDLFDVRDFGKVISAVSRLSLHSIAQNKGIRPFPSE 132


>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
           containing 1 [Homo sapiens]
          Length = 728

 Score = 38.9 bits (89), Expect = 0.005
 Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 8/106 (7%)

Query: 33  ELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQL------E 86
           +LR  IE    +S+  D    L DG +LC L+N ++P SV  I+       +L       
Sbjct: 585 QLRESIEMRLKVSLHEDLGAALMDGVVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRR 644

Query: 87  NLSNFIKAMVSYGMNPVDLFEANDLFESG--NMTQVQVSLLALAGK 130
           N+ NF++A    G+   DL    D+ +    ++ +   +LLAL  K
Sbjct: 645 NVENFLEACRKLGVPEADLCSPCDILQLDFRHIRKTVDTLLALGEK 690


>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
           containing 2 [Homo sapiens]
          Length = 765

 Score = 37.7 bits (86), Expect = 0.011
 Identities = 30/114 (26%), Positives = 52/114 (45%), Gaps = 7/114 (6%)

Query: 33  ELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQL------E 86
           +LR  +E    + +  D    L DG +LC L N ++P SV  I+       +L       
Sbjct: 651 QLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRR 710

Query: 87  NLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKMGTNKCASQS 140
           N+ NF+ A    G++   L   + + E   + +V V++ AL  ++ T K +  S
Sbjct: 711 NVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQALL-ELPTTKASQLS 763


>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
           sapiens]
          Length = 753

 Score = 36.6 bits (83), Expect = 0.024
 Identities = 38/166 (22%), Positives = 61/166 (36%), Gaps = 44/166 (26%)

Query: 51  QKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEAND 110
           Q  LKDG +LC L+ +L PG++ K                               F+AND
Sbjct: 32  QASLKDGVVLCRLLERLLPGTIEK------------------------------TFDAND 61

Query: 111 LFESGNMTQVQVSLLALAGKMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDH-STISL 169
           L++  N  +V  SL+ L      NK  +  G+   G+      P +H +   D   + SL
Sbjct: 62  LYQGQNFNKVLSSLVTL------NKVTADIGL---GSDSVCARPSSHRIKSFDSLGSQSL 112

Query: 170 QMGTNKCAS----QVGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMG 211
              T+K        + MT     + +   K    + +   +S   G
Sbjct: 113 HTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKG 158


>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
           containing 3 [Homo sapiens]
          Length = 712

 Score = 35.0 bits (79), Expect = 0.069
 Identities = 23/73 (31%), Positives = 35/73 (47%), Gaps = 6/73 (8%)

Query: 10  PSYGLSAEVKNRLLSKYDPQKEAEL------RTWIEGLTGLSIGPDFQKGLKDGTILCTL 63
           PS   + +  + +  +   Q+E EL      R  IE    +S+  D    L DG +LC L
Sbjct: 632 PSAAPTTDSTDSITGQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHL 691

Query: 64  MNKLQPGSVPKIN 76
            N ++P SVP I+
Sbjct: 692 ANHVRPRSVPSIH 704


>gi|28372563 growth arrest-specific 2 like 3 [Homo sapiens]
          Length = 694

 Score = 33.5 bits (75), Expect = 0.20
 Identities = 27/114 (23%), Positives = 52/114 (45%), Gaps = 17/114 (14%)

Query: 31  EAELRTWIEGLTGLSIGPD-FQKGLKDGTILCTLMNKLQ----------PGSVP------ 73
           + +L  W+ GL G+ +  +   + L +G +LC L++ LQ           G+ P      
Sbjct: 51  QEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQNMVKTCNSEESGNFPMRKVPC 110

Query: 74  KINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLAL 127
           K + +  ++   +N +NF+      G++   LFE+  L    +  QV + LL +
Sbjct: 111 KKDAASGSFFARDNTANFLHWCRDIGVDETYLFESEGLVLHKDPRQVYLCLLEI 164


>gi|17017974 wingless-type MMTV integration site family, member 11
           precursor [Homo sapiens]
          Length = 354

 Score = 32.0 bits (71), Expect = 0.58
 Identities = 19/58 (32%), Positives = 26/58 (44%), Gaps = 1/58 (1%)

Query: 146 GTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTR-RHIYDTKLGTDKCD 202
           GTR+HL      I P  D   + LQ   + C     + + GT+ R    T  G+D CD
Sbjct: 253 GTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCD 310


>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
          Length = 1127

 Score = 30.0 bits (66), Expect = 2.2
 Identities = 12/38 (31%), Positives = 22/38 (57%), Gaps = 2/38 (5%)

Query: 14  LSAEVKNRLLSKYDPQKEAELRTW--IEGLTGLSIGPD 49
           ++ E+   ++ KY+P KE + + W  I+G T   + PD
Sbjct: 376 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPD 413


>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
          Length = 1001

 Score = 30.0 bits (66), Expect = 2.2
 Identities = 12/38 (31%), Positives = 22/38 (57%), Gaps = 2/38 (5%)

Query: 14  LSAEVKNRLLSKYDPQKEAELRTW--IEGLTGLSIGPD 49
           ++ E+   ++ KY+P KE + + W  I+G T   + PD
Sbjct: 250 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPD 287


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,393,420
Number of Sequences: 37866
Number of extensions: 513791
Number of successful extensions: 1115
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1022
Number of HSP's gapped (non-prelim): 54
length of query: 270
length of database: 18,247,518
effective HSP length: 101
effective length of query: 169
effective length of database: 14,423,052
effective search space: 2437495788
effective search space used: 2437495788
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.