Guide to the Human Genome
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Search of human proteins with 41281450

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
         (951 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]                  2053   0.0  
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]                   2053   0.0  
gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens]      1381   0.0  
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa...   236   6e-62
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s...   225   2e-58
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot...   196   1e-49
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot...   194   4e-49
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo...   193   6e-49
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot...   189   1e-47
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot...   187   5e-47
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot...   184   3e-46
gi|124430557 a disintegrin-like and metalloprotease with thrombo...   176   7e-44
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo...   171   2e-42
gi|226442878 ADAMTS-like 5 [Homo sapiens]                             171   4e-42
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot...   164   5e-40
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo...   164   5e-40
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot...   163   6e-40
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo...   162   1e-39
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot...   162   2e-39
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo...   157   3e-38
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo...   156   8e-38
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]         154   4e-37
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s...   152   1e-36
gi|145309328 papilin [Homo sapiens]                                   150   5e-36
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t...   148   2e-35
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot...   140   6e-33
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo...   138   2e-32
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]                   138   3e-32
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo...   135   2e-31
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]         132   2e-30

>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
          Length = 951

 Score = 2053 bits (5320), Expect = 0.0
 Identities = 951/951 (100%), Positives = 951/951 (100%)

Query: 1   MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS 60
           MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS
Sbjct: 1   MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS 60

Query: 61  RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF 120
           RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF
Sbjct: 61  RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF 120

Query: 121 NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC 180
           NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC
Sbjct: 121 NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC 180

Query: 181 VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR 240
           VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR
Sbjct: 181 VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR 240

Query: 241 DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI 300
           DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI
Sbjct: 241 DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI 300

Query: 301 VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL 360
           VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL
Sbjct: 301 VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL 360

Query: 361 MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR 420
           MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR
Sbjct: 361 MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR 420

Query: 421 GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS 480
           GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS
Sbjct: 421 GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS 480

Query: 481 IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT 540
           IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT
Sbjct: 481 IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT 540

Query: 541 SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD 600
           SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD
Sbjct: 541 SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD 600

Query: 601 DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS 660
           DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS
Sbjct: 601 DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS 660

Query: 661 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC 720
           VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC
Sbjct: 661 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC 720

Query: 721 DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME 780
           DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME
Sbjct: 721 DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME 780

Query: 781 TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA 840
           TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA
Sbjct: 781 TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA 840

Query: 841 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ 900
           KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ
Sbjct: 841 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ 900

Query: 901 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 951
           ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
Sbjct: 901 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 951


>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
          Length = 951

 Score = 2053 bits (5320), Expect = 0.0
 Identities = 951/951 (100%), Positives = 951/951 (100%)

Query: 1   MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS 60
           MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS
Sbjct: 1   MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS 60

Query: 61  RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF 120
           RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF
Sbjct: 61  RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF 120

Query: 121 NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC 180
           NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC
Sbjct: 121 NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC 180

Query: 181 VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR 240
           VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR
Sbjct: 181 VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR 240

Query: 241 DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI 300
           DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI
Sbjct: 241 DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI 300

Query: 301 VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL 360
           VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL
Sbjct: 301 VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL 360

Query: 361 MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR 420
           MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR
Sbjct: 361 MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR 420

Query: 421 GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS 480
           GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS
Sbjct: 421 GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS 480

Query: 481 IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT 540
           IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT
Sbjct: 481 IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT 540

Query: 541 SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD 600
           SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD
Sbjct: 541 SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD 600

Query: 601 DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS 660
           DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS
Sbjct: 601 DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS 660

Query: 661 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC 720
           VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC
Sbjct: 661 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC 720

Query: 721 DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME 780
           DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME
Sbjct: 721 DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME 780

Query: 781 TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA 840
           TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA
Sbjct: 781 TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA 840

Query: 841 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ 900
           KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ
Sbjct: 841 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ 900

Query: 901 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 951
           ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
Sbjct: 901 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 951


>gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens]
          Length = 660

 Score = 1381 bits (3574), Expect = 0.0
 Identities = 637/638 (99%), Positives = 638/638 (100%)

Query: 314 VWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFVPHNGSLYGQ 373
           VWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGF+PHNGSLYGQ
Sbjct: 23  VWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFIPHNGSLYGQ 82

Query: 374 ASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTP 433
           ASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTP
Sbjct: 83  ASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTP 142

Query: 434 LTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAE 493
           LTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAE
Sbjct: 143 LTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAE 202

Query: 494 SFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRP 553
           SFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRP
Sbjct: 203 SFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRP 262

Query: 554 KARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPV 613
           KARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPV
Sbjct: 263 KARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPV 322

Query: 614 HEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 673
           HEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR
Sbjct: 323 HEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 382

Query: 674 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT 733
           PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT
Sbjct: 383 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT 442

Query: 734 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKN 793
           GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKN
Sbjct: 443 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKN 502

Query: 794 CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP 853
           CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP
Sbjct: 503 CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP 562

Query: 854 CFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 913
           CFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD
Sbjct: 563 CFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 622

Query: 914 DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 951
           DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
Sbjct: 623 DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 660


>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
            sapiens]
          Length = 1018

 Score =  236 bits (603), Expect = 6e-62
 Identities = 139/435 (31%), Positives = 205/435 (47%), Gaps = 28/435 (6%)

Query: 532  PNVSTSLLTSAGNRTHKARTRPKARKQGVSPADM-------YRWKLSSHEPCSATCTTGV 584
            P + TS         H  R  P      V PA         + WK      CS TC  G 
Sbjct: 578  PEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGS 637

Query: 585  MSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQ 643
                  CV R    E  +SYCD+  +P P  E C    C   W+   WSECS+TCG G Q
Sbjct: 638  QYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQ 697

Query: 644  FRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEM-SEWSECTAKCG 702
             R V C + +      +V    C+  E  +PE   TC+   C  +W++ ++W+ C+  CG
Sbjct: 698  HRQVLC-RQVYANRSLTVQPYRCQHLE--KPETTSTCQLKICS-EWQIRTDWTSCSVPCG 753

Query: 703  ERSVVTRDIRCSE------DEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGP-CSGSCGQ 755
                 TRD++C        D++ C+   RP   +NC   PC + W +++W   CS  CG 
Sbjct: 754  V-GQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGA 812

Query: 756  GRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNC--PAHWLAQDWERCNTTCGRG 813
            G   R V C T+    +P   C    +P    PC +  C     W A  W +C+  CG G
Sbjct: 813  GVRTRSVVCMTNHVSSLPLEGCG-NNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSG 871

Query: 814  VKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC-FKWYTSPWSECTKTCGVG 872
             ++R V+C+       +     EC   +KPP + +C  +PC  KW+++ WS C+K+C  G
Sbjct: 872  TQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGG 931

Query: 873  VRMRDVKCYQGTDIVRG-CDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVN 931
             R+R+V+C      +   CDP +KP  R++C+ Q C  E  D++C+D+   NC + ++  
Sbjct: 932  FRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPE-VDENCKDK-YYNCNVVVQAR 989

Query: 932  LCGHWYYSKACCRSC 946
            LC + YY  ACC SC
Sbjct: 990  LCVYNYYKTACCASC 1004



 Score =  173 bits (439), Expect = 6e-43
 Identities = 94/264 (35%), Positives = 140/264 (53%), Gaps = 18/264 (6%)

Query: 89  TCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPC 148
           +C G  ++Y+LC    CP   RS RE QC S+N+  + GR ++W+P          ++ C
Sbjct: 290 SCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVK----GNRKC 345

Query: 149 DLHCTTVDGQRQLMVPAR---DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGI 205
           +L+C  + G R  +  A    DGT C       +CVSG+C+ IGCD  L S   +DKCG+
Sbjct: 346 ELNCQAM-GYRFYVRQAEKVIDGTPCDQNGT-AICVSGQCKSIGCDDYLGSDKVVDKCGV 403

Query: 206 CQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFF 265
           C GD + C  V+G ++     LGY  V  IP GA  I I E  KS + LAL   +G    
Sbjct: 404 CGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSII 463

Query: 266 NGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSIT 325
           NGN+ +D P  +   GT+  Y+RP ++  T  E  +A+GPTN+ L+V + +Q   +P + 
Sbjct: 464 NGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQ-PNPGVH 522

Query: 326 FEYTLL--------QPPHESRPQP 341
           +EY ++         PPH    +P
Sbjct: 523 YEYVIMGTNAISPQVPPHRRPGEP 546



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 20/36 (55%), Positives = 22/36 (61%), Gaps = 1/36 (2%)

Query: 40 EGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCL 75
          +GG  A   W G W  W+ACSRSC GGV  Q R CL
Sbjct: 47 DGGGGAPGVW-GAWGPWSACSRSCSGGVMEQTRPCL 81



 Score = 31.6 bits (70), Expect = 3.7
 Identities = 32/124 (25%), Positives = 48/124 (38%), Gaps = 24/124 (19%)

Query: 22  GDTVSTGSTDNSPTSNSLEG---GTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQR 78
           GD V     +     N +E    G  A +++  EW++   CS  CG GV ++   C+   
Sbjct: 768 GDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSE--RCSAECGAGVRTRSVVCMTNH 825

Query: 79  RKSVPGPG-------------NRTCTGT----SKRYQLCRVQECPPDGRSFREEQCVSFN 121
             S+P  G             N  CTG     +  +  C + EC   G   RE  CV  N
Sbjct: 826 VSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSI-EC-GSGTQQREVICVRKN 883

Query: 122 SHVY 125
           +  +
Sbjct: 884 ADTF 887



 Score = 30.8 bits (68), Expect = 6.3
 Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 7/57 (12%)

Query: 54  TKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSK--RYQLCRVQECPPD 108
           T+W+ CS+SC GG   +E  CL           +  C    K    + C  Q+C P+
Sbjct: 919 TEWSMCSKSCQGGFRVREVRCLSDDMTL-----SNLCDPQLKPEERESCNPQDCVPE 970


>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
            sapiens]
          Length = 1074

 Score =  225 bits (573), Expect = 2e-58
 Identities = 130/403 (32%), Positives = 190/403 (47%), Gaps = 32/403 (7%)

Query: 568  WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
            WK   H  CSA+C  GV     +C+ R  G E+D+  C A  RP    E C G  C P W
Sbjct: 668  WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727

Query: 627  ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACG 686
            E   W+ CSR+CG G Q R ++C +    G  SSV  + C      RP   ++C+   CG
Sbjct: 728  EAGEWTSCSRSCGPGTQHRQLQCRQEFGGG-GSSVPPERC--GHLPRPNITQSCQLRLCG 784

Query: 687  PQWEM-SEWSECTAKCGERSVVTRDIRC--------SEDEKLCDPNTRPVGEKNCTGPPC 737
              WE+ S WS+C+ +CG R   +R +RC        SE E    P  +P   + C   PC
Sbjct: 785  -HWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGP-PQPPSREACDMGPC 841

Query: 738  DRQWTVSDW-GPCSGSCGQGRTIRHVYCKTSDGRVVP---------ESQCQMETKPLAIH 787
               W  SDW   CS  CG G   R V C  S   + P            C   ++P  + 
Sbjct: 842  TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMR 901

Query: 788  PCGDKNCPA--HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPE 845
             C    C     W    W  C++ CG G ++R ++C+     +    S   C    +PP 
Sbjct: 902  ACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPA 961

Query: 846  ESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQ-GTDIVRGCDPLVKPVGRQACD 903
               C  + C  +W+++PWS C+++C  G + R+V+C      +   C P ++P  ++ C+
Sbjct: 962  LQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCN 1021

Query: 904  LQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
             QPC ++ PDD C+D    +C L ++  LC + YY+  CCRSC
Sbjct: 1022 SQPC-SQRPDDQCKDS-SPHCPLVVQARLCVYPYYTATCCRSC 1062



 Score =  152 bits (384), Expect = 1e-36
 Identities = 86/247 (34%), Positives = 131/247 (53%), Gaps = 9/247 (3%)

Query: 90  CTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCD 149
           C+G S++ + C    CPP+    R  QC +FNS  + G+ +QW+P          S+ C+
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQ----GSQRCE 419

Query: 150 LHCTTVDGQRQLM--VPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQ 207
           L+C     +  +      +DGT C+      +CV+G+C   GCDG+L S    D CG+C 
Sbjct: 420 LNCRPRGFRFYVRHTEKVQDGTLCQ-PGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478

Query: 208 GDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNG 267
           GD S+C  V+GN       LGY  +  IPAGA  +QI + + S++ LAL    G    NG
Sbjct: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIING 538

Query: 268 NYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFE 327
           N+ VD P ++   GTV +Y RP      G E + A+GPT Q ++V +  Q  ++P + ++
Sbjct: 539 NWAVDPPGSYRAGGTVFRYNRPPREEGKG-ESLSAEGPTTQPVDVYMIFQE-ENPGVFYQ 596

Query: 328 YTLLQPP 334
           Y +  PP
Sbjct: 597 YVISSPP 603



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 42/137 (30%), Positives = 59/137 (43%), Gaps = 13/137 (9%)

Query: 553  PKARKQGVSPADM-YRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE---VDDSYCDALT 608
            P  R   + P +  +RW       CS+ C +G      +CV   G E      S C  L 
Sbjct: 898  PDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLP 957

Query: 609  RPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 668
            RP P  + C G+ CQ RW ++ WS CSR+C  G Q R V+C         +   S  C  
Sbjct: 958  RP-PALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLS------TNQTLSTRC-- 1008

Query: 669  AEAVRPEERKTCRNPAC 685
               +RP  ++ C +  C
Sbjct: 1009 PPQLRPSRKRPCNSQPC 1025



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 23/165 (13%)

Query: 774 ESQCQMETKPLAIHPCGDKNCPA-HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTR 832
           + Q ++   P   HP      PA +W       C+ +CG+GV + + LC+   +G+    
Sbjct: 643 QRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDE 702

Query: 833 SGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD 891
                G A+ P     C   PC   W    W+ C+++CG G + R ++C Q         
Sbjct: 703 RSCAAG-ARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ--------- 752

Query: 892 PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHW 936
                      +     +  P + C   P  N   + ++ LCGHW
Sbjct: 753 -----------EFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHW 786



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 8/73 (10%)

Query: 5  WQCSCWAWFLLVLAV---VAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSR 61
          W    W + LL+L++        V +G +  +PT      G +     WG W +W +CS+
Sbjct: 4  WTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQ--GPEGV---WGPWVQWASCSQ 58

Query: 62 SCGGGVTSQERHC 74
           CG GV  + R C
Sbjct: 59 PCGVGVQRRSRTC 71



 Score = 38.9 bits (89), Expect = 0.023
 Identities = 35/119 (29%), Positives = 44/119 (36%), Gaps = 35/119 (29%)

Query: 54   TKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFR 113
            T W+ CSRSC GG  ++E  CL           N+T +             CPP  R  R
Sbjct: 977  TPWSPCSRSCQGGTQTREVQCLST---------NQTLS-----------TRCPPQLRPSR 1016

Query: 114  EEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCK 172
            +  C   NS   + R        PDD    SS     HC  V   R  + P    T C+
Sbjct: 1017 KRPC---NSQPCSQR--------PDDQCKDSSP----HCPLVVQARLCVYPYYTATCCR 1060



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 2/55 (3%)

Query: 23  DTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQ 77
           D  S  +    P S     GT    +W  E  +WT+CSRSCG G   ++  C Q+
Sbjct: 701 DERSCAAGARPPASPEPCHGTPCPPYW--EAGEWTSCSRSCGPGTQHRQLQCRQE 753



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 48/197 (24%), Positives = 70/197 (35%), Gaps = 33/197 (16%)

Query: 22  GDTVS----TGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQ 77
           GD VS           P+  + + G   TA++  +W+  + CS  CG G+  +   CL  
Sbjct: 815 GDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWS--SKCSAECGTGIQRRSVVCLGS 872

Query: 78  RRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYP 137
                PG G     GT    Q C     PPD R+     C          RT +W   Y 
Sbjct: 873 GAALGPGQG-EAGAGTG---QSCPTGSRPPDMRACSLGPC---------ERTWRW---YT 916

Query: 138 DDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTD------LRGVCVSGKCEPIGCD 191
             +   SS+     C +   +R ++  ++ GT   +T       L        C+   C 
Sbjct: 917 GPWGECSSE-----CGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQ 971

Query: 192 GVLFSTHTLDKCGICQG 208
              FST        CQG
Sbjct: 972 DRWFSTPWSPCSRSCQG 988


>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
            preproprotein [Homo sapiens]
          Length = 1935

 Score =  196 bits (497), Expect = 1e-49
 Identities = 110/352 (31%), Positives = 160/352 (45%), Gaps = 25/352 (7%)

Query: 567  RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC--QP 624
            +W   +   C+  C  G+ +   +C R +G    D  C+ L +P P  E C    C    
Sbjct: 1385 QWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKP-PDREQCNTHACPHDA 1443

Query: 625  RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
             W T  WS CS +CG G++ R V C  M   G  S + SD C+     +P   + CR   
Sbjct: 1444 AWSTGPWSSCSVSCGRGHKQRNVYC--MAKDG--SHLESDYCK--HLAKPHGHRKCRGGR 1497

Query: 685  CGPQWEMSEWSECTAKCGERSVVTRDIRCS------EDEKLCDPNTRPVGEKNCTGPPCD 738
            C P+W+   WS+C+  CG R V  R + C         E  C+P TRP  E++C GP C 
Sbjct: 1498 C-PKWKAGAWSQCSVSCG-RGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCP 1555

Query: 739  RQ-WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH 797
               W   +W  C+ +CG+G   R V C   +   V  ++C +  +P+    C  + C   
Sbjct: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYV 1615

Query: 798  WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGL---AKKPPEESTCFERPC 854
            W+  +W  C+ TCG+G K+RLV C E+  GK       +  +     +PP    C+ R C
Sbjct: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDC 1675

Query: 855  ---FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG-CDPLVKPVGRQAC 902
                 W    W  C+ +CGVGV  R V+C    D     C   +KP  R+ C
Sbjct: 1676 PVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTC 1727



 Score =  193 bits (491), Expect = 6e-49
 Identities = 129/403 (32%), Positives = 170/403 (42%), Gaps = 64/403 (15%)

Query: 552  RPKARKQ-GVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRP 610
            RP A+++  V+P    +WK      CS TC  G  +   MCV Y    +D S CD    P
Sbjct: 1227 RPVAKEECSVTPCG--QWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIP 1284

Query: 611  EPVHEFCAGRECQPR---------------------------------WETSSWSECSRT 637
            E   + C+   C  R                                 W T  W  CS T
Sbjct: 1285 ETDQD-CSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSST 1343

Query: 638  CGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSEC 697
            C  G Q RVV C        D + Y+   +  E ++P+E++ C +  C PQW    W EC
Sbjct: 1344 CAGGSQRRVVVCQ-------DENGYT-ANDCVERIKPDEQRACESGPC-PQWAYGNWGEC 1394

Query: 698  TAKCGERSVVTRDIRC--SEDEKL----CDPNTRPVGEKNCTGPPC--DRQWTVSDWGPC 749
            T  CG   + TR + C  S  E+     C+   +P   + C    C  D  W+   W  C
Sbjct: 1395 TKLCGG-GIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSC 1453

Query: 750  SGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTT 809
            S SCG+G   R+VYC   DG  +    C+   KP     C    CP  W A  W +C+ +
Sbjct: 1454 SVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPK-WKAGAWSQCSVS 1512

Query: 810  CGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC--FKWYTSPWSECTK 867
            CGRGV++R V C     G  +     EC    +P  E  C    C  + W    W ECTK
Sbjct: 1513 CGRGVQQRHVGCQI---GTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTK 1569

Query: 868  TCGVGVRMRDVKCYQGT-DIVRG--CDPLVKPVGRQACDLQPC 907
            TCG G R R V C     + V G  CD   +PV R++C LQPC
Sbjct: 1570 TCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612



 Score =  190 bits (482), Expect = 6e-48
 Identities = 128/440 (29%), Positives = 180/440 (40%), Gaps = 79/440 (17%)

Query: 548  KARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDAL 607
            K   + K   Q  S     +WK      C  TC  G       C ++    ++D  CD  
Sbjct: 1036 KCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWC-QFGEDRLNDRMCDPE 1094

Query: 608  TRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCE 667
            T+P  + + C   EC   W+   W +CS TCG+GYQ R V+C   +   + S V  + C 
Sbjct: 1095 TKPTSM-QTCQQPECAS-WQAGPWGQCSVTCGQGYQLRAVKC---IIGTYMSVVDDNDCN 1149

Query: 668  AAEAVRPEERKTCRNPACGP-----------------QWEMSEWSECTAKCGE----RSV 706
            AA   RP + + C  P+C P                 QW    W+ C+A CG+    R V
Sbjct: 1150 AA--TRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYV 1207

Query: 707  VTRDIRCS-EDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCK 765
              RD   S  DE  C    RPV ++ C+  PC  QW   DW  CS +CGQGR  R V C 
Sbjct: 1208 SCRDENGSVADESACATLPRPVAKEECSVTPCG-QWKALDWSSCSVTCGQGRATRQVMCV 1266

Query: 766  TSDGRVVPESQCQMETKPLAIHPCGDKNCPAH---------------------------- 797
                 V+  S+C  +  P     C    CP                              
Sbjct: 1267 NYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHV 1326

Query: 798  -----WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFER 852
                 W    W  C++TC  G ++R+V+C +  NG     +  +C    KP E+  C   
Sbjct: 1327 LGGNQWRTGPWGACSSTCAGGSQRRVVVCQD-ENGY----TANDCVERIKPDEQRACESG 1381

Query: 853  PCFKWYTSPWSECTKTCGVGVRMRDVKCYQGT-----DIVRGCDPLVKPVGRQACDLQPC 907
            PC +W    W ECTK CG G+R R V C +       D+   C+ L KP  R+ C+   C
Sbjct: 1382 PCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDL--SCEILDKPPDREQCNTHAC 1439

Query: 908  PTEPPDDSCQDQPGTNCALA 927
               P D +    P ++C+++
Sbjct: 1440 ---PHDAAWSTGPWSSCSVS 1456



 Score =  188 bits (477), Expect = 2e-47
 Identities = 121/388 (31%), Positives = 162/388 (41%), Gaps = 45/388 (11%)

Query: 567  RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-----VDDSYCDALTRPEPVHEFCAGRE 621
            RW ++S   CSA C  G  +    C +Y  ++     VDD +C +  +P    E C+G  
Sbjct: 938  RWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSN-REKCSGEC 996

Query: 622  CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR 681
                W  S+W+ECS++C  G Q R   C    +   D S     C   E V  +    C 
Sbjct: 997  NTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDS----KCTHQEKVTIQR---CS 1049

Query: 682  NPACGPQWEMSEWSECTAKCGERSVVTRDIRC--SED---EKLCDPNTRPVGEKNCTGPP 736
               C PQW+  +WSEC   CG +    R + C   ED   +++CDP T+P   + C  P 
Sbjct: 1050 EFPC-PQWKSGDWSECLVTCG-KGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPE 1107

Query: 737  CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQMETKPLAIHPCGDKNC- 794
            C   W    WG CS +CGQG  +R V C       VV ++ C   T+P     C   +C 
Sbjct: 1108 C-ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCH 1166

Query: 795  --PA--------------HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECG 838
              PA               W    W  C+ TCG+G + R V C +  NG     S   C 
Sbjct: 1167 PPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRD-ENGSVADESA--CA 1223

Query: 839  LAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIV---RGCDPLVK 895
               +P  +  C   PC +W    WS C+ TCG G   R V C   +D V     CD    
Sbjct: 1224 TLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYI 1283

Query: 896  PVGRQACDLQPCPTEPPDDSCQDQPGTN 923
            P   Q C + PCP   PD      P  N
Sbjct: 1284 PETDQDCSMSPCPQRTPDSGLAQHPFQN 1311



 Score =  177 bits (450), Expect = 3e-44
 Identities = 115/415 (27%), Positives = 174/415 (41%), Gaps = 73/415 (17%)

Query: 552  RPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPE 611
            +P  R++     +   W+ S+   CS +C  G     A+CV      +DDS C   T  E
Sbjct: 985  KPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKC---THQE 1041

Query: 612  PVH-EFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSD-LCEAA 669
             V  + C+   C P+W++  WSEC  TCG+G++ R V C       F     +D +C+  
Sbjct: 1042 KVTIQRCSEFPC-PQWKSGDWSECLVTCGKGHKHRQVWCQ------FGEDRLNDRMCDPE 1094

Query: 670  EAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCS-------EDEKLCDP 722
               +P   +TC+ P C   W+   W +C+  CG+     R ++C         D+  C+ 
Sbjct: 1095 --TKPTSMQTCQQPECA-SWQAGPWGQCSVTCGQ-GYQLRAVKCIIGTYMSVVDDNDCNA 1150

Query: 723  NTRPVGEKNCTGPPCD-----------------RQWTVSDWGPCSGSCGQGRTIRHVYCK 765
             TRP   ++C  P C                   QW    W PCS +CG+G  +R+V C+
Sbjct: 1151 ATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCR 1210

Query: 766  TSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELA 825
              +G V  ES C    +P+A   C    C   W A DW  C+ TCG+G   R V+C+  +
Sbjct: 1211 DENGSVADESACATLPRPVAKEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYS 1269

Query: 826  NG---------------------KPQTRSGPECGLAKKPPEESTCFERPCF--------- 855
            +                       P  +  P+ GLA+ P +      R            
Sbjct: 1270 DHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGG 1329

Query: 856  -KWYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRGCDPLVKPVGRQACDLQPCP 908
             +W T PW  C+ TC  G + R V C  +       C   +KP  ++AC+  PCP
Sbjct: 1330 NQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP 1384



 Score =  150 bits (378), Expect = 7e-36
 Identities = 99/309 (32%), Positives = 139/309 (44%), Gaps = 32/309 (10%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           WG W+ +  CSR+CGGG+ +  R C     +  P  G + C G   +++ C  + C    
Sbjct: 591 WGSWSPFGTCSRTCGGGIKTAIREC----NRPEPKNGGKYCVGRRMKFKSCNTEPCLKQK 646

Query: 110 RSFREEQCVSFNSHVYNGR----THQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPA 165
           R FR+EQC  F+   +N        +W P Y      +    C L C          +  
Sbjct: 647 RDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGI---LMKDRCKLFCRVAGNTAYYQLRD 703

Query: 166 R--DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG 223
           R  DGT C   D   +CV G C   GCD VL S    DKCG+C GD SSC  V G +   
Sbjct: 704 RVIDGTPCG-QDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTF--N 760

Query: 224 NAHLGYSLVTHIPAGARDIQIVERKKSADV-----LALADEAGYYFFNGNYKVDSPK-NF 277
             H GY+ V  IPAGA +I + +   S +      LAL+   G +  NGN+ V   K   
Sbjct: 761 TVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREI 820

Query: 278 NIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGK--SPSITFEYTLLQPPH 335
            I   VV+Y       ET +E I +     Q L + V +  GK  +P + + + +   P 
Sbjct: 821 RIGNAVVEYSGS----ETAVERINSTDRIEQELLLQVLSV-GKLYNPDVRYSFNI---PI 872

Query: 336 ESRPQPIYY 344
           E +PQ  Y+
Sbjct: 873 EDKPQQFYW 881



 Score =  134 bits (337), Expect = 4e-31
 Identities = 98/356 (27%), Positives = 147/356 (41%), Gaps = 35/356 (9%)

Query: 607  LTRPEPVHEFCAGRECQPR---WETSS-WSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
            L  P+  + F    E +P+   W +   W  CS+ C +G + R + C +        +V 
Sbjct: 859  LYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPC-QGERKRKLVCTRESD---QLTVS 914

Query: 663  SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSE------- 715
               C+     +P          C  +W ++  SEC+A+CG     T DI C++       
Sbjct: 915  DQRCDRLP--QPGHITEPCGTDCDLRWHVASRSECSAQCG-LGYRTLDIYCAKYSRLDGK 971

Query: 716  ----DEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV 771
                D+  C  + +P   + C+G      W  S W  CS SC  G   R   C  +   V
Sbjct: 972  TEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDV 1031

Query: 772  VPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQT 831
            + +S+C  + K + I  C +  CP  W + DW  C  TCG+G K R V C +    +   
Sbjct: 1032 LDDSKCTHQEK-VTIQRCSEFPCP-QWKSGDWSECLVTCGKGHKHRQVWC-QFGEDRLND 1088

Query: 832  RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIV---- 887
            R    C    KP    TC +  C  W   PW +C+ TCG G ++R VKC  GT +     
Sbjct: 1089 RM---CDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDD 1145

Query: 888  RGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACC 943
              C+   +P   Q C+L  C   PP  + + +  T  A   +    G W    A C
Sbjct: 1146 NDCNAATRPTDTQDCELPSC--HPPPAAPETRRSTYSAPRTQWRF-GSWTPCSATC 1198



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 56/190 (29%), Positives = 87/190 (45%), Gaps = 11/190 (5%)

Query: 551  TRPKARKQGVSP-ADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTR 609
            TRP++ +    P   +Y W+    + C+ TC  G      +CV  +  EV  + CD   R
Sbjct: 1541 TRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKR 1600

Query: 610  PEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYS-DLCEA 668
            P    E C+ + C+  W T  WSECS TCG+GY+ R+V C ++ + G ++  YS      
Sbjct: 1601 PVD-RESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYT-GKENYEYSYQTTIN 1658

Query: 669  AEAVRPEERKTC--RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDE----KLCDP 722
                +P     C  R+      W +  W  C+  CG   V+ R ++C  +E     LC  
Sbjct: 1659 CPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGV-GVMQRSVQCLTNEDQPSHLCHT 1717

Query: 723  NTRPVGEKNC 732
            + +P   K C
Sbjct: 1718 DLKPEERKTC 1727



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 49/151 (32%), Positives = 60/151 (39%), Gaps = 21/151 (13%)

Query: 544  NRTHKART----RPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVR-YDGVE 598
            N  H AR     RP  R+        Y W       CS TC  G       C   Y G E
Sbjct: 1588 NEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKE 1647

Query: 599  -VDDSYCDAL----TRPEPVHEFCAGREC--QPRWETSSWSECSRTCGEGYQFRVVRCWK 651
              + SY   +    T+P  VH  C  R+C     W   +W  CS +CG G   R V+C  
Sbjct: 1648 NYEYSYQTTINCPGTQPPSVHP-CYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLT 1706

Query: 652  MLSPGFDSSVYSDLCEAAEAVRPEERKTCRN 682
                  +    S LC     ++PEERKTCRN
Sbjct: 1707 ------NEDQPSHLCHTD--LKPEERKTCRN 1729



 Score = 33.9 bits (76), Expect = 0.74
 Identities = 25/78 (32%), Positives = 31/78 (39%), Gaps = 18/78 (23%)

Query: 56   WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREE 115
            W+ CS SCG GV  Q+RH   Q              GT K   + R  EC P  R   E 
Sbjct: 1506 WSQCSVSCGRGV--QQRHVGCQ-------------IGTHK---IARETECNPYTRPESER 1547

Query: 116  QCVSFNSHVYNGRTHQWK 133
             C      +Y  R  +W+
Sbjct: 1548 DCQGPRCPLYTWRAEEWQ 1565



 Score = 33.5 bits (75), Expect = 0.97
 Identities = 22/79 (27%), Positives = 32/79 (40%), Gaps = 6/79 (7%)

Query: 29   STDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNR 88
            S+   P++     G   T  W   ++ WT CS+SC GG   +   C+  R   +    + 
Sbjct: 981  SSHPKPSNREKCSGECNTGGW--RYSAWTECSKSCDGGTQRRRAICVNTRNDVL---DDS 1035

Query: 89   TCTGTSK-RYQLCRVQECP 106
             CT   K   Q C    CP
Sbjct: 1036 KCTHQEKVTIQRCSEFPCP 1054


>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif,
           6 preproprotein [Homo sapiens]
          Length = 1117

 Score =  194 bits (492), Expect = 4e-49
 Identities = 102/279 (36%), Positives = 146/279 (52%), Gaps = 23/279 (8%)

Query: 38  SLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRY 97
           S++GG       WG W+ W  CSR+CGGGV+S  RHC        P  G + C G  KRY
Sbjct: 556 SIDGG-------WGPWSLWGECSRTCGGGVSSSLRHC----DSPAPSGGGKYCLGERKRY 604

Query: 98  QLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTT--V 155
           + C    CP   R FRE+QC  F++  + G+ + WKP     Y     KPC L+C     
Sbjct: 605 RSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKP-----YTGGGVKPCALNCLAEGY 659

Query: 156 DGQRQLMVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTH 215
           +   +      DGT C    L  +C++G+C+ +GCD +L S    D+C +C GDGS+C  
Sbjct: 660 NFYTERAPAVIDGTQCNADSL-DICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDA 718

Query: 216 VTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPK 275
           + G +       GY  V  IP G+  I++ E   S + +AL  E   Y+ NG + +D P+
Sbjct: 719 IEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPR 778

Query: 276 NFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMV 314
            F++AGT   Y+RP D  E+    + A GPT++ L VMV
Sbjct: 779 KFDVAGTAFHYKRPTDEPES----LEALGPTSENLIVMV 813



 Score =  150 bits (378), Expect = 7e-36
 Identities = 84/280 (30%), Positives = 127/280 (45%), Gaps = 23/280 (8%)

Query: 686  GPQWEMSEWSECTAKCGERSVVTRDIRCSE-------DEKLCDPNTRPV-GEKNCTGPPC 737
            G  W    WSEC+A C    V  +++ C             CDP+++P   ++ C   PC
Sbjct: 841  GFTWNHQPWSECSATCAG-GVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPC 899

Query: 738  DRQWTVSDWGPCSGSCGQGRTIRHVYC----KTSDGRVVPESQCQMETKPLAIHPCGDKN 793
              +W + DW  CS +C  G   R V C      S+   +  S C +  +P+   PC +++
Sbjct: 900  PPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGC-LTHRPVEKEPCNNQS 958

Query: 794  CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP 853
            CP  W+A DW  C   CG G K R+VLC   ++   +T    +C    KPP    C    
Sbjct: 959  CPPQWVALDWSECTPKCGPGFKHRIVLCK--SSDLSKTFPAAQCPEESKPPVRIRCSLGR 1016

Query: 854  C--FKWYTSPWSECTKTCGVGVRMRDVKCYQGT-DIVRGCDPLVKPVGRQACDLQPCPTE 910
            C   +W T  W +C+  CG+G +MR V+C   T      C   V+P   Q C+   C + 
Sbjct: 1017 CPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCE-SKCDST 1075

Query: 911  P--PDDSCQD-QPGTNCALAIKVNLCGHWYYSKACCRSCR 947
            P    + C+D      C L +K   C   Y+ + CC++C+
Sbjct: 1076 PISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 1115



 Score =  134 bits (338), Expect = 3e-31
 Identities = 74/235 (31%), Positives = 106/235 (45%), Gaps = 13/235 (5%)

Query: 566  YRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALTRPEPVHEFCAGRECQP 624
            + W       CSATC  GV     +C R D    V ++YCD  ++P      C    C P
Sbjct: 842  FTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPP 901

Query: 625  RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
             W    W ECS+TC  G + R V C + + P  + ++    C      RP E++ C N +
Sbjct: 902  EWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTH---RPVEKEPCNNQS 958

Query: 685  CGPQWEMSEWSECTAKCG----ERSVVTR--DIRCSEDEKLCDPNTRPVGEKNCTGPPC- 737
            C PQW   +WSECT KCG     R V+ +  D+  +     C   ++P     C+   C 
Sbjct: 959  CPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCP 1018

Query: 738  DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDK 792
              +W   DWG CS  CG G+ +R V C +  G+    S C    +P ++  C  K
Sbjct: 1019 PPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQA--SSDCLETVRPPSMQQCESK 1071



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 43/137 (31%), Positives = 62/137 (45%), Gaps = 12/137 (8%)

Query: 783 PLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKK 842
           P+     GD      W  Q W  C+ TC  GV+++ V+C  L +      +   C    K
Sbjct: 829 PITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNN--YCDPDSK 886

Query: 843 PPE-ESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKCY-------QGTDIVRGCDPL 893
           PPE +  C   PC  +W+   W EC+KTC  G+R R V C        + T    GC   
Sbjct: 887 PPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGC-LT 945

Query: 894 VKPVGRQACDLQPCPTE 910
            +PV ++ C+ Q CP +
Sbjct: 946 HRPVEKEPCNNQSCPPQ 962



 Score = 38.5 bits (88), Expect = 0.030
 Identities = 26/98 (26%), Positives = 41/98 (41%), Gaps = 7/98 (7%)

Query: 14  LLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERH 73
           L+V+ ++    +      N P + +  G  +   F W     W+ CS +C GGV  QE  
Sbjct: 809 LIVMVLLQEQNLGIRYKFNVPITRTGSGDNEV-GFTWNH-QPWSECSATCAGGVQRQEVV 866

Query: 74  CLQQRRKSVPGPGNRTCTGTSK---RYQLCRVQECPPD 108
           C +    S+    N  C   SK     + C  + CPP+
Sbjct: 867 CKRLDDNSI--VQNNYCDPDSKPPENQRACNTEPCPPE 902



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 20/76 (26%), Positives = 30/76 (39%), Gaps = 12/76 (15%)

Query: 845 EESTCFERPCFKWYTSP------------WSECTKTCGVGVRMRDVKCYQGTDIVRGCDP 892
           E+  C++  C  + T P            W EC++TCG GV      C        G   
Sbjct: 538 EKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYC 597

Query: 893 LVKPVGRQACDLQPCP 908
           L +    ++C+  PCP
Sbjct: 598 LGERKRYRSCNTDPCP 613



 Score = 30.4 bits (67), Expect = 8.2
 Identities = 22/93 (23%), Positives = 40/93 (43%), Gaps = 11/93 (11%)

Query: 31  DNSPTSNSLEGGTDATAFWW--GEWTKWTACSRSCGGGVTSQERHCLQQ----RRKSVPG 84
           D+ P  N     T+     W  G+W +   CS++C GG+ ++   C+++      +++  
Sbjct: 884 DSKPPENQRACNTEPCPPEWFIGDWLE---CSKTCDGGMRTRAVLCIRKIGPSEEETLDY 940

Query: 85  PGNRTCTGTSKRYQLCRVQECPPDGRSFREEQC 117
            G  T     K  + C  Q CPP   +    +C
Sbjct: 941 SGCLTHRPVEK--EPCNNQSCPPQWVALDWSEC 971


>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
           motif, 16 preproprotein [Homo sapiens]
          Length = 1224

 Score =  193 bits (491), Expect = 6e-49
 Identities = 113/325 (34%), Positives = 165/325 (50%), Gaps = 20/325 (6%)

Query: 42  GTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCR 101
           G   T   W +W+ W+ CSR+CGGGV+ + R C   +    P  G + C G+++  +LC 
Sbjct: 581 GPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPK----PSHGGKFCEGSTRTLKLCN 636

Query: 102 VQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKP-CDLHCTT--VDGQ 158
            Q+CP D   FR  QC   NS  + GR ++WKP     Y  +  +  C L+C     D  
Sbjct: 637 SQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKP-----YTQVEDQDLCKLYCIAEGFDFF 691

Query: 159 RQLMVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTG 218
             L    +DGT C   D R VC+ G CE +GCD VL S    D CG+C G+ S+CT   G
Sbjct: 692 FSLSNKVKDGTPCS-EDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRG 750

Query: 219 NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFN 278
            Y K +    Y  +  IP+GAR I+I E   S   +++ +    Y+ NG++ VD P  + 
Sbjct: 751 LYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYK 810

Query: 279 IAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESR 338
            +GT   YRR  +  E     ++A GPTN+ L V +  Q G++P + +EY++ +   E +
Sbjct: 811 FSGTTFDYRRSYNEPEN----LIATGPTNETLIVELLFQ-GRNPGVAWEYSMPRLGTEKQ 865

Query: 339 P--QPIYYGFSESAESQGLDGAGLM 361
           P  QP Y      +E     G G M
Sbjct: 866 PPAQPSYTWAIVRSECSVSCGGGQM 890



 Score =  170 bits (430), Expect = 7e-42
 Identities = 110/367 (29%), Positives = 159/367 (43%), Gaps = 47/367 (12%)

Query: 619  GRECQPRWETS-SW----SECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 673
            G E QP  + S +W    SECS +CG G       C++ L    + S  +        + 
Sbjct: 861  GTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLV 920

Query: 674  PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSE---------DEKLCDPNT 724
            P     C+  AC P W +  WS C+  CG     +R ++C+             LC P  
Sbjct: 921  P-----CKVSACPPSWSVGNWSACSRTCGG-GAQSRPVQCTRRVHYDSEPVPASLC-PQP 973

Query: 725  RPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD----GRVVPESQCQME 780
             P   + C    C   W+   W  CS +CG+G   R V CK+++     +++P++ C  E
Sbjct: 974  APSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSE 1033

Query: 781  TKPLAIHPCGDKNC----PAHWLAQDWERCNTTCGRGVKKRLVLCME-LANGKPQTRSGP 835
             KP     C  + C       WL   W +C+ TC RG +KR + C E   +GK +  +  
Sbjct: 1034 PKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASK 1093

Query: 836  ECGLAKKPPEE--STCFERPCFK-------------WYTSPWSECTKTCGVGVRMRDVKC 880
            +C    KP  E    C   PC +             W+ SPWS+CT +CG GV+ R V+C
Sbjct: 1094 KCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQC 1153

Query: 881  YQGTDIVRGCDPLVKPVGRQACDLQPCP-TEPPDDSCQDQPGTNCALAIKVNLCGHWYYS 939
              G     GC    KP    AC+   CP  E  D  C+D     C L  +  +C H +Y 
Sbjct: 1154 LAGGRPASGCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHW-CYLVPQHGMCSHKFYG 1212

Query: 940  KACCRSC 946
            K CC++C
Sbjct: 1213 KQCCKTC 1219



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 1/53 (1%)

Query: 56  WTACSRSCGGGVTSQERHCLQQ-RRKSVPGPGNRTCTGTSKRYQLCRVQECPP 107
           W+ACSR+CGGG  S+   C ++    S P P +          Q C  Q CPP
Sbjct: 936 WSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPP 988



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 48/212 (22%), Positives = 72/212 (33%), Gaps = 46/212 (21%)

Query: 729 EKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP 788
           E N   P    +  V  W PCS      R   H +  T+    + +     + KP+  + 
Sbjct: 454 EGNIMSPTLAGRNGVFSWSPCS------RQYLHKFLSTAQAICLAD-----QPKPVKEYK 502

Query: 789 CGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCM-----ELANGKPQTRSGPECGLAKKP 843
             +K      L  +    NT C     ++  LCM     ++       R G +C     P
Sbjct: 503 YPEK------LPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMP 556

Query: 844 PEEST-------CFERPCFKWYT-------------SPWSECTKTCGVGVRMRDVKCYQG 883
             E T       C    C K+               S WS C++TCG GV  R   C   
Sbjct: 557 AAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNP 616

Query: 884 TDIVRG--CDPLVKPVGRQACDLQPCPTEPPD 913
                G  C+   + +  + C+ Q CP +  D
Sbjct: 617 KPSHGGKFCEGSTRTL--KLCNSQKCPRDSVD 646



 Score = 31.6 bits (70), Expect = 3.7
 Identities = 12/27 (44%), Positives = 17/27 (62%), Gaps = 2/27 (7%)

Query: 51   GEW--TKWTACSRSCGGGVTSQERHCL 75
            G W  + W+ C+ SCGGGV ++   CL
Sbjct: 1128 GSWFASPWSQCTASCGGGVQTRSVQCL 1154



 Score = 31.2 bits (69), Expect = 4.8
 Identities = 13/21 (61%), Positives = 13/21 (61%)

Query: 629 SSWSECSRTCGEGYQFRVVRC 649
           SSWS CSRTCG G   R   C
Sbjct: 593 SSWSPCSRTCGGGVSHRSRLC 613



 Score = 31.2 bits (69), Expect = 4.8
 Identities = 28/93 (30%), Positives = 34/93 (36%), Gaps = 13/93 (13%)

Query: 59  CSRSCGGGVTSQERHCLQ----QRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFRE 114
           CS SCGGG  +    C +    Q   S   P  R  TG       C+V  CPP       
Sbjct: 881 CSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVP----CKVSACPPSWSVGNW 936

Query: 115 EQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKP 147
             C    S    G   Q +P+     VH  S+P
Sbjct: 937 SAC----SRTCGGGA-QSRPVQCTRRVHYDSEP 964



 Score = 30.4 bits (67), Expect = 8.2
 Identities = 19/61 (31%), Positives = 27/61 (44%), Gaps = 6/61 (9%)

Query: 683 PACGPQWEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCD 738
           P  G   + S WS C+  CG     RS +  + + S   K C+ +TR +  K C    C 
Sbjct: 584 PTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTL--KLCNSQKCP 641

Query: 739 R 739
           R
Sbjct: 642 R 642


>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
           12 preproprotein [Homo sapiens]
          Length = 1594

 Score =  189 bits (480), Expect = 1e-47
 Identities = 107/323 (33%), Positives = 173/323 (53%), Gaps = 23/323 (7%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           WG W+ W+ CSR+CG GV S ER C        P  G + CTG  KRY+LC V  C  + 
Sbjct: 545 WGRWSPWSHCSRTCGAGVQSAERLC----NNPEPKFGGKYCTGERKRYRLCNVHPCRSEA 600

Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQ--RQLMVPARD 167
            +FR+ QC  F++  Y    + W P++   +      PC+L+C  +DGQ   +++    D
Sbjct: 601 PTFRQMQCSEFDTVPYKNELYHWFPIFNPAH------PCELYCRPIDGQFSEKMLDAVID 654

Query: 168 GTSC-KLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
           GT C +  + R VC++G C+ +GCD  + S  T D+CG+C GDGSSC  V   +++    
Sbjct: 655 GTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGS 714

Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLAL-ADEAGYYFFNGNYKVDSPKNFNIAGTVVK 285
            GY  +  IP GARDI+++E + + + LA+ +++   Y+ NG + +    N+ +AGTV +
Sbjct: 715 -GYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQ 773

Query: 286 YRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP--PHESRPQPIY 343
           Y R  D     +E ++A GPTN+ + + +  Q   +P I +EYT+ +    ++   Q  +
Sbjct: 774 YDRKGD-----LEKLMATGPTNESVWIQLLFQ-VTNPGIKYEYTIQKDGLDNDVEQQMYF 827

Query: 344 YGFSESAESQGLDGAGLMGFVPH 366
           + +    E     G G+     H
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAH 850



 Score =  119 bits (298), Expect = 1e-26
 Identities = 75/240 (31%), Positives = 104/240 (43%), Gaps = 32/240 (13%)

Query: 626  WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
            W   +WSECS TCG G  +R V C    S   DS      C A +  RP+  K C    C
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVEC----STQMDSD-----CAAIQ--RPDPAKRCHLRPC 1365

Query: 686  GPQWEMSEWSECTAKCGERSVVTRDIRC--SEDEKLCDP-------NTRPVGEKNCTGPP 736
               W++  WS+C+  C     + R+I+C  S D +   P          P    +C   P
Sbjct: 1366 AG-WKVGNWSKCSRNCSGGFKI-REIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEP 1423

Query: 737  CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPA 796
            C+  W V  W  CS SCG G   R V+C        P   C    +P +   C +  C  
Sbjct: 1424 CEA-WQVEPWSQCSRSCGGGVQERGVFC--------PGGLCDWTKRPTSTMSCNEHLC-C 1473

Query: 797  HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK 856
            HW   +W+ C+T+CG G +KR V C+     K + +    C    +PPE   C ++ C K
Sbjct: 1474 HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKK 1533



 Score =  110 bits (274), Expect = 8e-24
 Identities = 78/274 (28%), Positives = 109/274 (39%), Gaps = 27/274 (9%)

Query: 689  WEMSEWSECTAKCGERSVVTRDIRCSED-EKLCDPNTRPVGEKNCTGPPCDRQWTVSDWG 747
            W +  WSEC+  CG      R + CS   +  C    RP   K C   PC   W V +W 
Sbjct: 1317 WIVGNWSECSTTCG-LGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPC-AGWKVGNWS 1374

Query: 748  PCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMET---KPLAIHPCGDKNCPAHWLAQDW 803
             CS +C  G  IR + C  S D R +    CQ       PL++  C  + C A W  + W
Sbjct: 1375 KCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMS-CNPEPCEA-WQVEPW 1432

Query: 804  ERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWS 863
             +C+ +CG GV++R V C            G  C   K+P    +C E  C  W T  W 
Sbjct: 1433 SQCSRSCGGGVQERGVFC-----------PGGLCDWTKRPTSTMSCNEHLCCHWATGNWD 1481

Query: 864  ECTKTCGVGVRMRDVKCYQGTDIVRG------CDPLVKPVGRQACDLQPCPTEPPDDSCQ 917
             C+ +CG G + R V+C               CD   +P   + C+ Q C         +
Sbjct: 1482 LCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTK 1541

Query: 918  DQPGTNCALAIK-VNLCGHWYYSKACCRSCRPPH 950
            D+   +    +K +  C        CC SC   H
Sbjct: 1542 DKLSASFCQTLKAMKKCSVPTVRAECCFSCPQTH 1575



 Score =  107 bits (268), Expect = 4e-23
 Identities = 62/174 (35%), Positives = 80/174 (45%), Gaps = 8/174 (4%)

Query: 741 WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP-CGDKNCPAHWL 799
           W    W  CS +CG G   +  +C      +V  + C  ET+P      C +K CP  W 
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887

Query: 800 AQDWERCNTTCG-RGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCF--- 855
           A +WE C+ TCG  G KKR VLC++      Q     +C    KP    +C  R      
Sbjct: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSC-NRDILCPS 946

Query: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPT 909
            W    WSEC+ +CG GVR+R V C +  D    CD   KP  R  C LQ CP+
Sbjct: 947 DWTVGNWSECSVSCGGGVRIRSVTCAKNHD--EPCDVTRKPNSRALCGLQQCPS 998



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 66/230 (28%), Positives = 101/230 (43%), Gaps = 14/230 (6%)

Query: 565  MYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 624
            MY W+      CS TC TG+    A C++     V  ++CD  T+P    + C  + C P
Sbjct: 825  MYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPP 884

Query: 625  RWETSSWSECSRTCG-EGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTC-RN 682
            RW    W  CS TCG  G + R V C + +     +   +D C+    ++P+   +C R+
Sbjct: 885  RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTD-CQ--HLLKPKTLLSCNRD 941

Query: 683  PACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-EKLCDPNTRPVGEKNCTGPPCDRQW 741
              C   W +  WSEC+  CG   V  R + C+++ ++ CD   +P     C    C    
Sbjct: 942  ILCPSDWTVGNWSECSVSCG-GGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSR 1000

Query: 742  TVSDWGPCSGSCGQGR---TIRHVYCKTSDGRVV--PESQCQMETKPLAI 786
             V    P  G+   G+   T++ V   TS  R++  P     M T   AI
Sbjct: 1001 RVLK--PNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAI 1048



 Score = 90.5 bits (223), Expect = 7e-18
 Identities = 51/178 (28%), Positives = 74/178 (41%), Gaps = 11/178 (6%)

Query: 730  KNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPC 789
            K  T       W V +W  CS +CG G   R V C T       +S C    +P     C
Sbjct: 1306 KQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQ-----MDSDCAAIQRPDPAKRC 1360

Query: 790  GDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC 849
              + C A W   +W +C+  C  G K R + C++  + +       +      PP   +C
Sbjct: 1361 HLRPC-AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSC 1419

Query: 850  FERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC 907
               PC  W   PWS+C+++CG GV+ R V C  G      CD   +P    +C+   C
Sbjct: 1420 NPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGL-----CDWTKRPTSTMSCNEHLC 1472



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 38/137 (27%), Positives = 62/137 (45%), Gaps = 22/137 (16%)

Query: 796  AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCF 855
            AHW+  +W  C+TTCG G   R V C         T+   +C   ++P     C  RPC 
Sbjct: 1315 AHWIVGNWSECSTTCGLGAYWRRVEC--------STQMDSDCAAIQRPDPAKRCHLRPCA 1366

Query: 856  KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPL-------VKPVGRQACDLQPCP 908
             W    WS+C++ C  G ++R+++C    D  R   P        + P    +C+ +PC 
Sbjct: 1367 GWKVGNWSKCSRNCSGGFKIREIQCVDSRD-HRNLRPFHCQFLAGIPPPLSMSCNPEPC- 1424

Query: 909  TEPPDDSCQDQPGTNCA 925
                 ++ Q +P + C+
Sbjct: 1425 -----EAWQVEPWSQCS 1436



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 52/183 (28%), Positives = 71/183 (38%), Gaps = 28/183 (15%)

Query: 568  WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTR-PEPVHEFCAGRECQPR 625
            WK+ +   CS  C+ G       CV   D   +   +C  L   P P+   C    C+  
Sbjct: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA- 1426

Query: 626  WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
            W+   WS+CSR+CG G Q R V C     PG        LC+  +  RP    +C    C
Sbjct: 1427 WQVEPWSQCSRSCGGGVQERGVFC-----PG-------GLCDWTK--RPTSTMSCNEHLC 1472

Query: 686  GPQWEMSEWSECTAKCGERSVVTRDIRC---------SEDEKLCDPNTRPVGEKNCTGPP 736
               W    W  C+  CG      R ++C          +D+ LCD   RP   K C    
Sbjct: 1473 -CHWATGNWDLCSTSCG-GGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQA 1530

Query: 737  CDR 739
            C +
Sbjct: 1531 CKK 1533



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 39/133 (29%), Positives = 50/133 (37%), Gaps = 13/133 (9%)

Query: 553  PKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEP 612
            P       +P     W++     CS +C  GV           GV      CD   RP  
Sbjct: 1412 PPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQER--------GVFCPGGLCDWTKRPTS 1463

Query: 613  VHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAV 672
                C    C   W T +W  CS +CG G+Q R V+C  + S G + +   D C      
Sbjct: 1464 TMS-CNEHLC-CHWATGNWDLCSTSCGGGFQKRTVQC--VPSEG-NKTEDQDQCLCDHKP 1518

Query: 673  RPEERKTCRNPAC 685
            RP E K C   AC
Sbjct: 1519 RPPEFKKCNQQAC 1531



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 23/62 (37%), Positives = 34/62 (54%), Gaps = 4/62 (6%)

Query: 851 ERPCFKWYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRG--CDPLVKPVGRQ-ACDLQP 906
           E+  + W    W+EC+ TCG G+R +   C  +G  +V+   CDP  +P GRQ  C  + 
Sbjct: 822 EQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKA 881

Query: 907 CP 908
           CP
Sbjct: 882 CP 883



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 22/81 (27%), Positives = 38/81 (46%), Gaps = 1/81 (1%)

Query: 37  NSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKR 96
           + L+   +   ++W ++  WT CS +CG G+  Q  HC+++ R  V        T  + R
Sbjct: 815 DGLDNDVEQQMYFW-QYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGR 873

Query: 97  YQLCRVQECPPDGRSFREEQC 117
            + C  + CPP   +   E C
Sbjct: 874 QKKCHEKACPPRWWAGEWEAC 894



 Score = 37.0 bits (84), Expect = 0.088
 Identities = 17/53 (32%), Positives = 26/53 (49%)

Query: 860 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPP 912
           SPWS C++TCG GV+  +  C        G     +    + C++ PC +E P
Sbjct: 549 SPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAP 601



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 21/63 (33%), Positives = 28/63 (44%), Gaps = 12/63 (19%)

Query: 52   EWT--KWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSK--RYQLCRVQECPP 107
            +WT   W+ CS SCGGGV  +   C +          +  C  T K     LC +Q+CP 
Sbjct: 947  DWTVGNWSECSVSCGGGVRIRSVTCAKNH--------DEPCDVTRKPNSRALCGLQQCPS 998

Query: 108  DGR 110
              R
Sbjct: 999  SRR 1001



 Score = 34.3 bits (77), Expect = 0.57
 Identities = 19/62 (30%), Positives = 27/62 (43%), Gaps = 10/62 (16%)

Query: 56   WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREE 115
            W  CS SCGGG   +   C       VP  GN+T     +   LC  +  PP+ +   ++
Sbjct: 1480 WDLCSTSCGGGFQKRTVQC-------VPSEGNKT---EDQDQCLCDHKPRPPEFKKCNQQ 1529

Query: 116  QC 117
             C
Sbjct: 1530 AC 1531



 Score = 32.3 bits (72), Expect = 2.2
 Identities = 35/140 (25%), Positives = 49/140 (35%), Gaps = 28/140 (20%)

Query: 663 SDLCEAAEAVRPEERKTCRNPAC-----------GPQWEMSEWSECTAKCGERSVVTRDI 711
           S L  AA+  +  E+K C    C           G     S WS C+  CG         
Sbjct: 509 SKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCG--------A 560

Query: 712 RCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV 771
                E+LC+      G K CTG    +++ + +  PC     +  T R + C   D   
Sbjct: 561 GVQSAERLCNNPEPKFGGKYCTGE--RKRYRLCNVHPCR---SEAPTFRQMQCSEFD--T 613

Query: 772 VPESQCQMETKPL--AIHPC 789
           VP         P+    HPC
Sbjct: 614 VPYKNELYHWFPIFNPAHPC 633



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 25/101 (24%), Positives = 37/101 (36%), Gaps = 6/101 (5%)

Query: 562 PADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRE 621
           P    RW   SH  CS TC  GV SA  +C   +  +    YC   T     +  C    
Sbjct: 542 PGGWGRWSPWSH--CSRTCGAGVQSAERLCNNPE-PKFGGKYC---TGERKRYRLCNVHP 595

Query: 622 CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
           C+    T    +CS      Y+  +   + + +P     +Y
Sbjct: 596 CRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELY 636



 Score = 30.4 bits (67), Expect = 8.2
 Identities = 11/19 (57%), Positives = 13/19 (68%)

Query: 56   WTACSRSCGGGVTSQERHC 74
            W+ CSRSCGGGV  +   C
Sbjct: 1432 WSQCSRSCGGGVQERGVFC 1450


>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
           18 preproprotein [Homo sapiens]
          Length = 1221

 Score =  187 bits (474), Expect = 5e-47
 Identities = 108/298 (36%), Positives = 152/298 (51%), Gaps = 23/298 (7%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           W  W+KW+ CSR+CGGGV  QERHC   +    P  G   C G+S+ YQLC +  C  + 
Sbjct: 592 WSAWSKWSECSRTCGGGVKFQERHCNNPK----PQYGGLFCPGSSRIYQLCNINPCNENS 647

Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKP-CDLHCTTVDGQRQLMVPAR-- 166
             FR +QC  +NS  + G  +QWKP     Y  +  +  C L+C   + +    +  +  
Sbjct: 648 LDFRAQQCAEYNSKPFRGWFYQWKP-----YTKVEEEDRCKLYCKAENFEFFFAMSGKVK 702

Query: 167 DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
           DGT C   +   VC+ G CE +GCD  L S    D CG+C+GD S+C    G Y   +  
Sbjct: 703 DGTPCS-PNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKA 761

Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKY 286
             Y  V  IPAGAR I+I E + S+  LA+   +  Y+  G + +D P  F  AGT  +Y
Sbjct: 762 NEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEY 821

Query: 287 RRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQ-----PPHESRP 339
           +R  +      E + A GPTN+ L   +  Q GK+P I ++Y L +     PP   RP
Sbjct: 822 QRSFN----RPERLYAPGPTNETLVFEILMQ-GKNPGIAWKYALPKVMNGTPPATKRP 874



 Score =  172 bits (436), Expect = 1e-42
 Identities = 116/345 (33%), Positives = 153/345 (44%), Gaps = 40/345 (11%)

Query: 632  SECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEM 691
            SECS +CG GY      C +      ++ V S  C +A+     E K C   +C   W  
Sbjct: 883  SECSVSCGGGYINVKAICLR----DQNTQVNSSFC-SAKTKPVTEPKICNAFSCPAYWMP 937

Query: 692  SEWSECTAKC--GERSVVTRDIRCSEDE----------KLCDPNTRPVGEKNCTGPPCDR 739
             EWS C+  C  G++S   R I+C + +           LC P + P   + C    C  
Sbjct: 938  GEWSTCSKACAGGQQS---RKIQCVQKKPFQKEEAVLHSLC-PVSTPTQVQACNSHACPP 993

Query: 740  QWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH-- 797
            QW++  W  CS +CG+G   R + CK S    +PESQC    +P     C    CP +  
Sbjct: 994  QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSR 1053

Query: 798  --WLAQDWERCNTTCGRGVKKRLVLCMELA-NGKPQTRSGPECGLAKKP--PEESTCFER 852
              W+A  W  C+ TCG GV+KR + C E    GK  T     C   KKP    E TC  R
Sbjct: 1054 LQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRR 1113

Query: 853  PC---------FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACD 903
             C           WY+ PW +CT TCG GV+ R V C Q       C    KP   +AC+
Sbjct: 1114 ACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACN 1173

Query: 904  LQ--PCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
                P P +  D SC D     C L  +  +C H +Y K CC+SC
Sbjct: 1174 TNFCPAPEKREDPSCVDFFNW-CHLVPQHGVCNHKFYGKQCCKSC 1217



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 6/74 (8%)

Query: 47   AFWW-GEWTKWTACSRSCGGGVTSQERHCLQQR--RKSVPGPGNRTCTGTSKRYQLCRVQ 103
            A+W  GEW+    CS++C GG  S++  C+Q++  +K      +     T  + Q C   
Sbjct: 933  AYWMPGEWS---TCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSH 989

Query: 104  ECPPDGRSFREEQC 117
             CPP        QC
Sbjct: 990  ACPPQWSLGPWSQC 1003



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 11/68 (16%)

Query: 56   WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKR--YQLCRVQECP-PDGRSF 112
            W  C+ +CGGGV ++  HC+QQ R S       +C    K    + C    CP P+ R  
Sbjct: 1132 WQQCTVTCGGGVQTRSVHCVQQGRPS------SSCLLHQKPPVLRACNTNFCPAPEKR-- 1183

Query: 113  REEQCVSF 120
             +  CV F
Sbjct: 1184 EDPSCVDF 1191



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 17/41 (41%), Positives = 21/41 (51%), Gaps = 10/41 (24%)

Query: 610 PEPVHEFCAGRECQPRWET-SSWSECSRTCGEGYQFRVVRC 649
           P P+H          +W   S WSECSRTCG G +F+   C
Sbjct: 585 PRPIHG---------QWSAWSKWSECSRTCGGGVKFQERHC 616



 Score = 33.5 bits (75), Expect = 0.97
 Identities = 16/48 (33%), Positives = 23/48 (47%)

Query: 860 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC 907
           S WSEC++TCG GV+ ++  C        G          Q C++ PC
Sbjct: 596 SKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPC 643



 Score = 31.2 bits (69), Expect = 4.8
 Identities = 16/57 (28%), Positives = 27/57 (47%), Gaps = 5/57 (8%)

Query: 56   WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSK--RYQLCRVQECPPDGR 110
            W+ CS++CG GV  +E  C     +++P      CT   +    + C +  CP + R
Sbjct: 1000 WSQCSKTCGRGVRKRELLCKGSAAETLP---ESQCTSLPRPELQEGCVLGRCPKNSR 1053


>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
           7 preproprotein [Homo sapiens]
          Length = 1686

 Score =  184 bits (467), Expect = 3e-46
 Identities = 105/300 (35%), Positives = 160/300 (53%), Gaps = 23/300 (7%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           W  W+ W+ CSRSCG GV S ER C Q      P    R C G  KR++LC +Q CP   
Sbjct: 541 WSGWSAWSICSRSCGMGVQSAERQCTQP----TPKYKGRYCVGERKRFRLCNLQACPAGR 596

Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDG--QRQLMVPARD 167
            SFR  QC  F++ +Y G+ H W P+  D        PC+LHC   +     +L     D
Sbjct: 597 PSFRHVQCSHFDAMLYKGQLHTWVPVVND------VNPCELHCRPANEYFAEKLRDAVVD 650

Query: 168 GTSC-KLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
           GT C ++   R +C++G C+ +GCD  + S    D+CG+C G+GS+C  V+G + +    
Sbjct: 651 GTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEG- 709

Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLAL-ADEAGYYFFNGNYKVDSPKNFNIAGTVVK 285
           LGY  V  IPAGAR+I+I E  ++A+ LAL +++   YF NG + +    ++ +AGT   
Sbjct: 710 LGYVDVGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFT 769

Query: 286 YRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPP--HESRPQPIY 343
           Y R         E + + GPT + + + +  Q   +P + +EYT+ +    H+  P P++
Sbjct: 770 YAR-----RGNWENLTSPGPTKEPVWIQLLFQE-SNPGVHYEYTIHREAGGHDEVPPPVF 823



 Score =  140 bits (353), Expect = 6e-33
 Identities = 96/293 (32%), Positives = 121/293 (41%), Gaps = 32/293 (10%)

Query: 669  AEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-EKLCDPNTRPV 727
            AEA  P +    RN      W+   WSEC+  CG    V R +RCS   ++ C P  RP 
Sbjct: 1399 AEAGPPADPLVVRNAG----WQAGNWSECSTTCG-LGAVWRPVRCSSGRDEDCAPAGRPQ 1453

Query: 728  GEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQM-ETKPLA 785
              + C   PC   W   +W  CS SCG G ++R V C  T D R +    CQ    KP A
Sbjct: 1454 PARRCHLRPC-ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPA 1512

Query: 786  IHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGL---AKK 842
              PCG + C + W    W  C+  CG G ++RLV C             PE GL   A +
Sbjct: 1513 HRPCGAQPCLS-WYTSSWRECSEACGGGEQQRLVTC-------------PEPGLCEEALR 1558

Query: 843  PPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQ-----GTDIVRGCDPLVKPV 897
            P     C   PC +W   PW +C+  CG GV+ R VKC         +    C     P 
Sbjct: 1559 PNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPE 1618

Query: 898  GRQACDLQPC-PTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPP 949
              + C  + C P EPP           C     +  C        CCRSC PP
Sbjct: 1619 SSRPCGTEDCEPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPP 1671



 Score =  124 bits (310), Expect = 5e-28
 Identities = 78/238 (32%), Positives = 102/238 (42%), Gaps = 33/238 (13%)

Query: 626  WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
            W+  +WSECS TCG G  +R VRC    S G D        + A A RP+  + C    C
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRC----SSGRDE-------DCAPAGRPQPARRCHLRPC 1463

Query: 686  GPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL-------CDPN-TRPVGEKNCTGPPC 737
               W    WS+C+  CG  S V RD++C +   L       C P   +P   + C   PC
Sbjct: 1464 A-TWHSGNWSKCSRSCGGGSSV-RDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC 1521

Query: 738  DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPE-SQCQMETKPLAIHPCGDKNCPA 796
               W  S W  CS +CG G   R V C        PE   C+   +P    PC    C  
Sbjct: 1522 -LSWYTSSWRECSEACGGGEQQRLVTC--------PEPGLCEEALRPNTTRPCNTHPC-T 1571

Query: 797  HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC 854
             W+   W +C+  CG GV++RLV C+    G P+  S  +CG    P     C    C
Sbjct: 1572 QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDS-DQCGHEAWPESSRPCGTEDC 1628



 Score =  105 bits (263), Expect = 2e-22
 Identities = 87/282 (30%), Positives = 112/282 (39%), Gaps = 30/282 (10%)

Query: 526  SSEAPFPN--VSTSLLTSAGNRTHKARTRPKARK--QGVSPADMY-----RWKLSSHEPC 576
            S E P  +  +ST    S  N      T+P A    +   PAD        W+  +   C
Sbjct: 1364 SPEVPLSSRLLSTPAWDSPANSHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSEC 1423

Query: 577  SATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSR 636
            S TC  G +     C         D  C    RP+P    C  R C   W + +WS+CSR
Sbjct: 1424 STTCGLGAVWRPVRC-----SSGRDEDCAPAGRPQPARR-CHLRPC-ATWHSGNWSKCSR 1476

Query: 637  TCGEGYQFRVVRC--WKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEW 694
            +CG G   R V+C   + L P     +    C+   A  P  R     P     W  S W
Sbjct: 1477 SCGGGSSVRDVQCVDTRDLRP-----LRPFHCQPGPAKPPAHRPCGAQPCL--SWYTSSW 1529

Query: 695  SECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCG 754
             EC+  CG      R + C E   LC+   RP   + C   PC  QW V  WG CSG CG
Sbjct: 1530 RECSEACG-GGEQQRLVTCPE-PGLCEEALRPNTTRPCNTHPC-TQWVVGPWGQCSGPCG 1586

Query: 755  QGRTIRHVYCKTSDGRVVPE--SQCQMETKPLAIHPCGDKNC 794
             G   R V C  +   +  E   QC  E  P +  PCG ++C
Sbjct: 1587 GGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628



 Score =  103 bits (256), Expect = 1e-21
 Identities = 57/178 (32%), Positives = 82/178 (46%), Gaps = 7/178 (3%)

Query: 735 PPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPL-AIHPCGDKN 793
           PP    W    W  C+ +CG+G   ++VYC       V E  C    +P      C ++ 
Sbjct: 819 PPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQP 878

Query: 794 CPAHWLAQDWERCNTTCGRG-VKKRLVLCMELANGKPQTR-SGPECGLAKKPPEESTCFE 851
           CPA W A +W+ C+++CG G + +R VLC+       Q+    P C    +PP E+ C  
Sbjct: 879 CPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNR 938

Query: 852 R-PC-FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC 907
             PC   W    WS+C+ TCG G + R+V C   T +   CD   +P     C L  C
Sbjct: 939 HVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGV--PCDEAQQPASEVTCSLPLC 994



 Score =  102 bits (255), Expect = 1e-21
 Identities = 57/196 (29%), Positives = 83/196 (42%), Gaps = 8/196 (4%)

Query: 562  PADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRE 621
            P  ++ W       C+ TC  GV      C+      VD+ +CD L RP+     C+ + 
Sbjct: 819  PPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQP 878

Query: 622  CQPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTC 680
            C  RW    W  CS +CG  G   R V C + +     S++    CE     RP     C
Sbjct: 879  CPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACE--HLPRPPTETPC 936

Query: 681  -RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL-CDPNTRPVGEKNCTGPPCD 738
             R+  C   W +  WS+C+  CGE     R++ C+ D  + CD   +P  E  C+ P C 
Sbjct: 937  NRHVPCPATWAVGNWSQCSVTCGE-GTQRRNVLCTNDTGVPCDEAQQPASEVTCSLPLC- 994

Query: 739  RQWTVSDWGPCSGSCG 754
             +W +   GP     G
Sbjct: 995  -RWPLGTLGPEGSGSG 1009



 Score =  101 bits (252), Expect = 3e-21
 Identities = 61/193 (31%), Positives = 88/193 (45%), Gaps = 18/193 (9%)

Query: 722  PNTRPVGEKNC-TGPPCD------RQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPE 774
            P T+P+       GPP D        W   +W  CS +CG G   R V C  S GR   +
Sbjct: 1389 PETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRC--SSGR---D 1443

Query: 775  SQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSG 834
              C    +P     C  + C A W + +W +C+ +CG G   R V C++  + +P     
Sbjct: 1444 EDCAPAGRPQPARRCHLRPC-ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFH 1502

Query: 835  PECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLV 894
             + G AK PP    C  +PC  WYTS W EC++ CG G + R V C +       C+  +
Sbjct: 1503 CQPGPAK-PPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPE----PGLCEEAL 1557

Query: 895  KPVGRQACDLQPC 907
            +P   + C+  PC
Sbjct: 1558 RPNTTRPCNTHPC 1570



 Score =  100 bits (249), Expect = 6e-21
 Identities = 60/182 (32%), Positives = 83/182 (45%), Gaps = 23/182 (12%)

Query: 689 WEMSEWSECTAKCGERSVVTRDIRCSE------DEKLCDPNTRPVGE-KNCTGPPCDRQW 741
           W    W++CT  CG R V  +++ C E      DE+ CDP  RP  + + C+  PC  +W
Sbjct: 825 WHYGPWTKCTVTCG-RGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARW 883

Query: 742 TVSDWGPCSGSCGQGRTIRH-VYCKTSDG----RVVPESQCQMETKPLAIHPCGDK-NCP 795
              +W  CS SCG G   R  V C  S G      +    C+   +P    PC     CP
Sbjct: 884 WAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCP 943

Query: 796 AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCF 855
           A W   +W +C+ TCG G ++R VLC           +G  C  A++P  E TC   P  
Sbjct: 944 ATWAVGNWSQCSVTCGEGTQRRNVLC--------TNDTGVPCDEAQQPASEVTC-SLPLC 994

Query: 856 KW 857
           +W
Sbjct: 995 RW 996



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 26/60 (43%), Positives = 35/60 (58%), Gaps = 4/60 (6%)

Query: 853 PCFKWYTSPWSECTKTCGVGVRMRDVKCYQ---GTDIVRGCDPLVKPVGRQ-ACDLQPCP 908
           P F W+  PW++CT TCG GV+ ++V C +   G      CDPL +P  +Q  C  QPCP
Sbjct: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 36/137 (26%), Positives = 45/137 (32%), Gaps = 19/137 (13%)

Query: 553  PKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEP 612
            P  R  G  P     W  SS   CS  C  G       C        +   C+   RP  
Sbjct: 1511 PAHRPCGAQPC--LSWYTSSWRECSEACGGGEQQRLVTCP-------EPGLCEEALRPNT 1561

Query: 613  VHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLS--PGFDSSVYSDLCEAAE 670
                C    C  +W    W +CS  CG G Q R+V+C    +  P  DS       +   
Sbjct: 1562 TRP-CNTHPCT-QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSD------QCGH 1613

Query: 671  AVRPEERKTCRNPACGP 687
               PE  + C    C P
Sbjct: 1614 EAWPESSRPCGTEDCEP 1630



 Score = 38.9 bits (89), Expect = 0.023
 Identities = 18/53 (33%), Positives = 30/53 (56%)

Query: 860 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPP 912
           S WS C+++CG+GV+  + +C Q T   +G   + +    + C+LQ CP   P
Sbjct: 545 SAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRP 597



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 28/98 (28%), Positives = 39/98 (39%), Gaps = 22/98 (22%)

Query: 41  GGTDAT---AFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSV----------PGPGN 87
           GG D      F W  +  WT C+ +CG GV  Q  +CL+++   V          P    
Sbjct: 813 GGHDEVPPPVFSW-HYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQ 871

Query: 88  RTCTGT-------SKRYQLCRVQECPPDGRSFREEQCV 118
           R C+         +  +QLC    C P G S R   C+
Sbjct: 872 RKCSEQPCPARWWAGEWQLCS-SSCGPGGLSRRAVLCI 908



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 11/23 (47%), Positives = 16/23 (69%)

Query: 56   WTACSRSCGGGVTSQERHCLQQR 78
            W+ CSRSCGGG + ++  C+  R
Sbjct: 1471 WSKCSRSCGGGSSVRDVQCVDTR 1493


>gi|124430557 a disintegrin-like and metalloprotease with
            thrombospondin type 1 motifs 20 [Homo sapiens]
          Length = 1910

 Score =  176 bits (447), Expect = 7e-44
 Identities = 110/393 (27%), Positives = 160/393 (40%), Gaps = 65/393 (16%)

Query: 565  MYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 624
            M +W+  S  PCS +C  G  + Y  C        D+SYC  L RP  + +      C  
Sbjct: 1153 MAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFT--PCG- 1209

Query: 625  RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
             W+   WS CS +CG G   R V C     P     +  + C+    VRP   + C   A
Sbjct: 1210 EWQAGDWSPCSASCGHGKTTRQVLCMNYHQP-----IDENYCDPE--VRPLMEQECSLAA 1262

Query: 685  CGP-----------------------------------------QWEMSEWSECTAKCG- 702
            C P                                         QW    W  C++ C  
Sbjct: 1263 CPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSG 1322

Query: 703  ---ERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTI 759
                R+VV +D    +    CD  ++P   + C   PC  QW   +WG CS +CG G   
Sbjct: 1323 GLQHRAVVCQDEN-GQSASYCDAASKPPELQQCGPGPCP-QWNYGNWGECSQTCGGGIKS 1380

Query: 760  RHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPA--HWLAQDWERCNTTCGRGVKKR 817
            R V C+  +G+++ +  C++  KP ++  C    CPA   W  + W  C+ +CG+G K R
Sbjct: 1381 RLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYR 1440

Query: 818  LVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRD 877
             V C++    K +  +   C   +KPP    C    C  W  + W+EC+ TCG GV+ RD
Sbjct: 1441 EVFCIDQFQRKLEDTN---CSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRD 1497

Query: 878  VKCY---QGTDIVRGCDPLVKPVGRQACDLQPC 907
            V C     G  +   CD   +P  ++ C  Q C
Sbjct: 1498 VYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530



 Score =  175 bits (443), Expect = 2e-43
 Identities = 111/373 (29%), Positives = 154/373 (41%), Gaps = 46/373 (12%)

Query: 567  RWKLSSHEPCSATCTTGVMSAYAMCVRYD-----GVEVDDSYCDALTRPEPVHEFCAGRE 621
            RW +     CS+ C  G  +    C++Y       V+VDD YC    +P P  E C G  
Sbjct: 907  RWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKP-PTQELCHGNC 965

Query: 622  CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR 681
               RW  S WS+CSR+CG G + R   C       F   +  + C+    V    R+ C 
Sbjct: 966  VFTRWHYSEWSQCSRSCGGGERSRESYCMN----NFGHRLADNECQELSRV---TRENCN 1018

Query: 682  NPACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-----EKLCDPNTRPVGEKNCTGPP 736
              +C P W  SEWSEC   CG +    R + C  +     +  C+ +T+P     C    
Sbjct: 1019 EFSC-PSWAASEWSECLVTCG-KGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHT 1076

Query: 737  CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAIHPCGDKNCP 795
            C   W V  WGPC+ +CG G  +R V C       V+ +++C   ++P     C    C 
Sbjct: 1077 C-ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCS 1135

Query: 796  ------------------AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPEC 837
                              A W    W  C+ +CGRG + R V C +  +   +      C
Sbjct: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALD---RIADESYC 1192

Query: 838  GLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKC--YQGTDIVRGCDPLVK 895
                +P E   CF  PC +W    WS C+ +CG G   R V C  Y        CDP V+
Sbjct: 1193 AHLPRPAEIWDCF-TPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVR 1251

Query: 896  PVGRQACDLQPCP 908
            P+  Q C L  CP
Sbjct: 1252 PLMEQECSLAACP 1264



 Score =  162 bits (410), Expect = 1e-39
 Identities = 118/413 (28%), Positives = 154/413 (37%), Gaps = 92/413 (22%)

Query: 567  RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
            RW  S    CS +C  G  S  + C+   G  + D+ C  L+R     E C    C P W
Sbjct: 969  RWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRV--TRENCNEFSC-PSW 1025

Query: 627  ETSSWSECSRTCGEGYQFRVVRCW---KMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNP 683
              S WSEC  TCG+G + R V C      LS GF +S          + +PE    C   
Sbjct: 1026 AASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNS----------STKPESLSPCELH 1075

Query: 684  ACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-------EKLCDPNTRPVGEKNCTGPP 736
             C   W++  W  CT  CG      RD++C  +       +  C   +RP   ++C   P
Sbjct: 1076 TCA-SWQVGPWGPCTTTCGH-GYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTP 1133

Query: 737  CD------------------RQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQ 778
            C                    QW    W PCS SCG+G   R+V C+ +  R+  ES C 
Sbjct: 1134 CSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCA 1193

Query: 779  METKPLAI----HPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSG 834
               +P  I     PCG+      W A DW  C+ +CG G   R VLCM       +    
Sbjct: 1194 HLPRPAEIWDCFTPCGE------WQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCD 1247

Query: 835  P--------ECGLAKKPPEESTCFERPC------------------------------FK 856
            P        EC LA  PP  S     P                                +
Sbjct: 1248 PEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQ 1307

Query: 857  WYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRGCDPLVKPVGRQACDLQPCP 908
            W T PW  C+ +C  G++ R V C  +       CD   KP   Q C   PCP
Sbjct: 1308 WRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCP 1360



 Score =  153 bits (386), Expect = 8e-37
 Identities = 89/251 (35%), Positives = 128/251 (50%), Gaps = 25/251 (9%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           WG W  +++CSR+CGGG+ S  R C     +  P  G   C G   +++ C    CP   
Sbjct: 559 WGPWEPYSSCSRTCGGGIESATRRC----NRPEPRNGGNYCVGRRMKFRSCNTDSCPKGT 614

Query: 110 RSFREEQCVSFNSHVYN----GRTHQWKPLYPDDYVHISSKP-CDLHCTTVDGQRQLMVP 164
           + FRE+QC  FN    +        +W P Y      I +K  C L+C         ++ 
Sbjct: 615 QDFREKQCSDFNGKHLDISGIPSNVRWLPRYSG----IGTKDRCKLYCQVAGTNYFYLLK 670

Query: 165 --ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRK 222
               DGT C  T+   +CV G+C   GCD VL S+  +DKCG+C GD SSC  +TG +  
Sbjct: 671 DMVEDGTPCG-TETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVF-- 727

Query: 223 GNAHLGYSLVTHIPAGARDIQIVERKKSA----DVLALADEAGYYFFNGNYKVD-SPKNF 277
            ++H GY++V  IPAGA ++ I +   S       LAL+D  G + FNGN+ +  S K  
Sbjct: 728 NSSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEI 787

Query: 278 NIAG--TVVKY 286
           N+ G  TV++Y
Sbjct: 788 NVQGTRTVIEY 798



 Score =  149 bits (376), Expect = 1e-35
 Identities = 109/378 (28%), Positives = 158/378 (41%), Gaps = 47/378 (12%)

Query: 563  ADMYRWK-LSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGR 620
            +DM+ W      E C+  C  G+      C+ + D   V D  CD L  P  V + C   
Sbjct: 845  SDMFTWDPYGPWEGCTKMCQ-GLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSC-NT 902

Query: 621  ECQPRWETSSWSECSRTCGEGYQFRVVRCWK-MLSPGFDSSVYSDLCEAAEAVRPEERKT 679
            +C+ RW     SECS  CG+GY+   + C K  +  G    V    C   + ++P  ++ 
Sbjct: 903  DCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYC--GDQLKPPTQEL 960

Query: 680  CRNPACGPQWEMSEWSECTAKC--GERSVVTRDIRCSED--EKLCDPNTRP---VGEKNC 732
            C       +W  SEWS+C+  C  GERS   R+  C  +   +L D   +    V  +NC
Sbjct: 961  CHGNCVFTRWHYSEWSQCSRSCGGGERS---RESYCMNNFGHRLADNECQELSRVTRENC 1017

Query: 733  TGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDK 792
                C   W  S+W  C  +CG+G   R V+C+ +    + +  C   TKP ++ PC   
Sbjct: 1018 NEFSCP-SWAASEWSECLVTCGKGTKQRQVWCQLNVDH-LSDGFCNSSTKPESLSPCELH 1075

Query: 793  NCPAHWLAQDWERCNTTCGRGVKKRLVLCM-ELANGKPQTRSGPECGLAKKPPEESTCFE 851
             C A W    W  C TTCG G + R V C+ ELA+         EC  A +P +  +C  
Sbjct: 1076 TC-ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASA---VLEDTECHEASRPSDRQSCVL 1131

Query: 852  RPC-------------------FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG--- 889
             PC                    +W    W+ C+ +CG G + R V C    D +     
Sbjct: 1132 TPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESY 1191

Query: 890  CDPLVKPVGRQACDLQPC 907
            C  L +P     C   PC
Sbjct: 1192 CAHLPRPAEIWDC-FTPC 1208



 Score =  135 bits (340), Expect = 2e-31
 Identities = 94/369 (25%), Positives = 151/369 (40%), Gaps = 30/369 (8%)

Query: 558  QGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFC 617
            Q   P    +W   +   CS TC  G+ S   +C   +G  ++D  C+ + +P  V + C
Sbjct: 1352 QQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQ-C 1410

Query: 618  AGRECQP--RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPE 675
                C     W    W+ CS +CG+G ++R V C        + +        ++  +P 
Sbjct: 1411 HMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDT------NCSQVQKPP 1464

Query: 676  ERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSED------EKLCDPNTRPVGE 729
              K CR+  C P W+ + W+EC+  CG   V  RD+ C         E++CD +TRP  +
Sbjct: 1465 THKACRSVRC-PSWKANSWNECSVTCGS-GVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQ 1522

Query: 730  KNCTGPPCDRQWTVSDWG-PCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP 788
            + C    C +   +      CS SC +  + + + C  +  R V E      T  L    
Sbjct: 1523 RRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKN 1582

Query: 789  CGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQT--RSGP----ECGLAKK 842
            C +  C    +  D  +C   CG   ++R+  C E+ + K     R  P    EC +   
Sbjct: 1583 CRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVV-- 1640

Query: 843  PPEESTCFERPCFK---WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG-CDPLVKPVG 898
            P  +       C     W    WS+C+ TCG+G+  R VKC     +    C   +KP  
Sbjct: 1641 PSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGA 1700

Query: 899  RQACDLQPC 907
            ++ C    C
Sbjct: 1701 QKKCYANDC 1709



 Score =  123 bits (309), Expect = 7e-28
 Identities = 92/353 (26%), Positives = 144/353 (40%), Gaps = 31/353 (8%)

Query: 567  RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
            +W+      CS++C+ G+     +C   +G     SYCDA ++P  + + C    C P+W
Sbjct: 1307 QWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSA--SYCDAASKPPELQQ-CGPGPC-PQW 1362

Query: 627  ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDL-CEAAEAVRPEERKTCRNPAC 685
               +W ECS+TCG G + R+V C        +  +  D  CE     +P     C   AC
Sbjct: 1363 NYGNWGECSQTCGGGIKSRLVICQFP-----NGQILEDHNCEIVN--KPPSVIQCHMHAC 1415

Query: 686  GPQ--WEMSEWSECTAKCGERSVVTRDIRCSED--EKLCDPNT----RPVGEKNCTGPPC 737
                 W    W+ C+A CG+     R++ C +    KL D N     +P   K C    C
Sbjct: 1416 PADVSWHQEPWTSCSASCGKGRKY-REVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRC 1474

Query: 738  DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH 797
               W  + W  CS +CG G   R VYC+      V E  C   T+P +   C  ++C  H
Sbjct: 1475 P-SWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQH 1533

Query: 798  -WLAQDWERCNTTCGRGVKKRLVLCM--ELANGKPQTRSGPECGLAKKPPEESTCFERPC 854
              + +    C+T+C R    + + C   ++        +     L  K      C   PC
Sbjct: 1534 KGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSK-----NCRNPPC 1588

Query: 855  -FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQP 906
             +   T+  S+C   CG   R R   C +     +     ++P+  Q C + P
Sbjct: 1589 NYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVP 1641



 Score = 37.7 bits (86), Expect = 0.051
 Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 3/42 (7%)

Query: 34  PTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCL 75
           PT     G    T + + EW++   CSRSCGGG  S+E +C+
Sbjct: 956 PTQELCHGNCVFTRWHYSEWSQ---CSRSCGGGERSRESYCM 994



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 19/71 (26%), Positives = 34/71 (47%), Gaps = 13/71 (18%)

Query: 56   WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREE 115
            WT+CS SCG G   +E  C+ Q ++ +    +  C+   K          PP  ++ R  
Sbjct: 1426 WTSCSASCGKGRKYREVFCIDQFQRKLE---DTNCSQVQK----------PPTHKACRSV 1472

Query: 116  QCVSFNSHVYN 126
            +C S+ ++ +N
Sbjct: 1473 RCPSWKANSWN 1483



 Score = 31.6 bits (70), Expect = 3.7
 Identities = 15/42 (35%), Positives = 18/42 (42%), Gaps = 6/42 (14%)

Query: 614 HEFCAGRECQPRWETSSW------SECSRTCGEGYQFRVVRC 649
           H  C  +E + R     W      S CSRTCG G +    RC
Sbjct: 542 HGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRC 583



 Score = 30.4 bits (67), Expect = 8.2
 Identities = 19/62 (30%), Positives = 27/62 (43%), Gaps = 10/62 (16%)

Query: 51   GEWTK--WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKR---YQLCRVQEC 105
            GEW    W+ CS SCG G T+++  C+   +     P +        R    Q C +  C
Sbjct: 1209 GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQ-----PIDENYCDPEVRPLMEQECSLAAC 1263

Query: 106  PP 107
            PP
Sbjct: 1264 PP 1265


>gi|112789555 ADAM metallopeptidase with thrombospondin type 1
           motif, 19 preproprotein [Homo sapiens]
          Length = 1207

 Score =  171 bits (434), Expect = 2e-42
 Identities = 108/311 (34%), Positives = 160/311 (51%), Gaps = 32/311 (10%)

Query: 43  TDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGN--RTCTGTSKRYQLC 100
           T A     GEW+ W+ CSR+C  G++S+ER C        PG  +  R C G  K+Y++C
Sbjct: 629 TSAPEHLAGEWSLWSPCSRTCSAGISSRERKC--------PGLDSEARDCNGPRKQYRIC 680

Query: 101 RVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQ 160
               CP     FR+ QC       Y+ RT   K +     V    KPC L C+ V  ++ 
Sbjct: 681 ENPPCPAGLPGFRDWQC-----QAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQP 735

Query: 161 LMVPAR--DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTG 218
           +++  +  DGTSC    L  +C +G+C+ +GCDG+L S    D CG+C G+G SC  + G
Sbjct: 736 ILLSEKVMDGTSCGYQGL-DICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKG 794

Query: 219 NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFN 278
           ++       GY  V  IPAGAR I++VE K +   LAL D AG    N ++K++    FN
Sbjct: 795 DFNHTRG-AGYVEVLVIPAGARRIKVVEEKPAHSYLALRD-AGKQSINSDWKIEHSGAFN 852

Query: 279 IAGTVVKYRRPMDVYETGI-EYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPP--- 334
           +AGT V Y R       G+ E I A+GPT   L+++V     ++  + +EYT+   P   
Sbjct: 853 LAGTTVHYVR------RGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPE 906

Query: 335 --HESRPQPIY 343
                 P+P++
Sbjct: 907 NQSSKAPEPLF 917



 Score =  140 bits (352), Expect = 7e-33
 Identities = 81/242 (33%), Positives = 110/242 (45%), Gaps = 18/242 (7%)

Query: 561  SPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE---VDDSYCDALTRPEPVHEFC 617
            +P  ++ W  +S E C ATC  G       C +        VD+  C  LT+PEP    C
Sbjct: 912  APEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKC 971

Query: 618  AGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAE----AVR 673
              + CQ RW  + W+ CSRTCG+G Q R V C + LS G        L  A E      +
Sbjct: 972  NEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNG-------TLIRARERDCIGPK 1024

Query: 674  PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT 733
            P   + C    C   WE   WSEC+ KCG + +  R +RC+   K C  +TRP   ++C 
Sbjct: 1025 PASAQRCEGQDCMTVWEAGVWSECSVKCG-KGIRHRTVRCTNPRKKCVLSTRPREAEDCE 1083

Query: 734  GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAIHPCGDK 792
                   W + DW  CS +CG+G   R + C     GR    ++C    KP A  PC  +
Sbjct: 1084 DYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGR--HGNECFSSEKPAAYRPCHLQ 1141

Query: 793  NC 794
             C
Sbjct: 1142 PC 1143



 Score =  133 bits (335), Expect = 7e-31
 Identities = 75/256 (29%), Positives = 117/256 (45%), Gaps = 26/256 (10%)

Query: 611  EPVHEFCAGRECQP--RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 668
            +P+ E  + +  +P   W  +SW +C  TCG G +   V C K++S    S V ++ C+ 
Sbjct: 902  DPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNI-SIVDNEKCKY 960

Query: 669  AEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSED----------EK 718
                 P+ RK C    C  +W M+EW+ C+  CG + + +R + C++           E+
Sbjct: 961  LTKPEPQIRK-CNEQPCQTRWMMTEWTPCSRTCG-KGMQSRQVACTQQLSNGTLIRARER 1018

Query: 719  LCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQ 778
             C    +P   + C G  C   W    W  CS  CG+G   R V C        P  +C 
Sbjct: 1019 DCI-GPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTN------PRKKCV 1071

Query: 779  METKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECG 838
            + T+P     C D +    W   DW +C+ TCG+G++ R++ CM    G    R G EC 
Sbjct: 1072 LSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITG----RHGNECF 1127

Query: 839  LAKKPPEESTCFERPC 854
             ++KP     C  +PC
Sbjct: 1128 SSEKPAAYRPCHLQPC 1143



 Score =  133 bits (334), Expect = 9e-31
 Identities = 86/302 (28%), Positives = 136/302 (45%), Gaps = 41/302 (13%)

Query: 676  ERKTCRNPACGPQWEMSEWSECTAKCG--ERS-------VVTRDIRCSEDEKLCDPNTRP 726
            E ++ + P     W  + W +C A CG  ER        +++++I   ++EK C   T+P
Sbjct: 906  ENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEK-CKYLTKP 964

Query: 727  VGE-KNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC--KTSDGRVVP--ESQCQMET 781
              + + C   PC  +W +++W PCS +CG+G   R V C  + S+G ++   E  C +  
Sbjct: 965  EPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDC-IGP 1023

Query: 782  KPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAK 841
            KP +   C  ++C   W A  W  C+  CG+G++ R V C         T    +C L+ 
Sbjct: 1024 KPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC---------TNPRKKCVLST 1074

Query: 842  KPPEESTCFE-RPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG--CDPLVKPVG 898
            +P E   C +   C+ W    WS+C+ TCG G++ R ++C        G  C    KP  
Sbjct: 1075 RPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAA 1134

Query: 899  RQACDLQPCP--------TEP-----PDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRS 945
             + C LQPC         T P           DQ    C +  + NLC    + + CC +
Sbjct: 1135 YRPCHLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCET 1194

Query: 946  CR 947
            CR
Sbjct: 1195 CR 1196



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 92/376 (24%), Positives = 132/376 (35%), Gaps = 96/376 (25%)

Query: 615 EFCAGRECQPRW--------ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC 666
           ++C   EC  R         E S WS CSRTC  G   R  +C     PG DS       
Sbjct: 618 KWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC-----PGLDS------- 665

Query: 667 EAAEAVRPEER-KTCRN---PACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDP 722
           EA +   P ++ + C N   PA  P +   +    + +      + +     ++EK C  
Sbjct: 666 EARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEEKPCAL 725

Query: 723 NTRPVG--------EKNCTGPPCDRQWT-VSDWGPCS--GSCGQ-GRTIRHVYCKTSDGR 770
              PVG        EK   G  C  Q   +   G C   G  G  G   R  +C   +G 
Sbjct: 726 FCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGN 785

Query: 771 -----------------------VVPESQCQM---ETKP----LAIHPCGDKNCPAHWLA 800
                                  V+P    ++   E KP    LA+   G ++  + W  
Sbjct: 786 GKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSINSDWKI 845

Query: 801 QD---WERCNTTCG---RGVKKR-------------LVLCMELAN-GKPQTRSGPECGLA 840
           +    +    TT     RG+ ++             LVL  +  N G     + P   L 
Sbjct: 846 EHSGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPL- 904

Query: 841 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKC----YQGTDIV--RGCDPLV 894
             P  +S+    P F W  + W +C  TCG G R   V C     +   IV    C  L 
Sbjct: 905 --PENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLT 962

Query: 895 KPVGR-QACDLQPCPT 909
           KP  + + C+ QPC T
Sbjct: 963 KPEPQIRKCNEQPCQT 978



 Score = 37.0 bits (84), Expect = 0.088
 Identities = 27/92 (29%), Positives = 39/92 (42%), Gaps = 12/92 (13%)

Query: 834 GPECGLAK-----KPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVR 888
           G +C L K     +    ++  E    +W  S WS C++TC  G+  R+ KC       R
Sbjct: 611 GTDCDLGKWCKAGECTSRTSAPEHLAGEW--SLWSPCSRTCSAGISSRERKCPGLDSEAR 668

Query: 889 GCDPLVKPVGRQACDLQPCPTEPP---DDSCQ 917
            C+   K    + C+  PCP   P   D  CQ
Sbjct: 669 DCNGPRKQY--RICENPPCPAGLPGFRDWQCQ 698



 Score = 37.0 bits (84), Expect = 0.088
 Identities = 20/54 (37%), Positives = 28/54 (51%), Gaps = 2/54 (3%)

Query: 54   TKWTACSRSCGGGVTSQERHCLQQ-RRKSVPGPGNRTCTGTS-KRYQLCRVQEC 105
            T+WT CSR+CG G+ S++  C QQ    ++     R C G      Q C  Q+C
Sbjct: 983  TEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDC 1036



 Score = 30.8 bits (68), Expect = 6.3
 Identities = 15/52 (28%), Positives = 25/52 (48%), Gaps = 6/52 (11%)

Query: 56   WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSK--RYQLCRVQEC 105
            W+ CS +CG G+ S+   C+ +    + G     C  + K   Y+ C +Q C
Sbjct: 1096 WSKCSITCGKGMQSRVIQCMHK----ITGRHGNECFSSEKPAAYRPCHLQPC 1143



 Score = 30.4 bits (67), Expect = 8.2
 Identities = 17/61 (27%), Positives = 23/61 (37%), Gaps = 4/61 (6%)

Query: 48  FWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTC---TGTSKRYQLCRVQE 104
           F W   T W  C  +CGGG       C +   K++    N  C   T    + + C  Q 
Sbjct: 917 FMWTH-TSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQP 975

Query: 105 C 105
           C
Sbjct: 976 C 976


>gi|226442878 ADAMTS-like 5 [Homo sapiens]
          Length = 471

 Score =  171 bits (432), Expect = 4e-42
 Identities = 112/300 (37%), Positives = 148/300 (49%), Gaps = 29/300 (9%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           W  W  WT CS SCG GV+ + R CL+        PG   C G S  Y+LC++ +CPP  
Sbjct: 38  WTPWVSWTRCSSSCGRGVSVRSRRCLRL-------PGEEPCWGDSHEYRLCQLPDCPPGA 90

Query: 110 RSFREEQCVSFNSHVYNG--RTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPAR- 166
             FR+ QC  +N     G  +T+QW P       H +   CDL+C   +G        R 
Sbjct: 91  VPFRDLQCALYNGRPVLGTQKTYQWVPF------HGAPNQCDLNCLA-EGHAFYHSFGRV 143

Query: 167 -DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNA 225
            DGT+C     +GVCV+G+C   GCDG+L S    D+CG C G   SC  V   +R   A
Sbjct: 144 LDGTACS-PGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGA 202

Query: 226 HLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVK 285
             GY  VT IP GAR I++  R  S + LAL    G Y  NG++ V  P  +  AGT V 
Sbjct: 203 FAGYWNVTLIPEGARHIRVEHR--SRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVV 260

Query: 286 YRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQ---PPHESRPQPI 342
           Y R     ET    + A GPT+  L + V  Q   +P I FE+ L +    P ++R Q +
Sbjct: 261 YTRDTGPQET----LQAAGPTSHDLLLQVLLQE-PNPGIEFEFWLPRERYSPFQARVQAL 315



 Score = 34.3 bits (77), Expect = 0.57
 Identities = 17/50 (34%), Positives = 23/50 (46%), Gaps = 1/50 (2%)

Query: 795 PAHWLAQ-DWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKP 843
           P  W     W RC+++CGRGV  R   C+ L   +P      E  L + P
Sbjct: 35  PGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLP 84



 Score = 32.7 bits (73), Expect = 1.7
 Identities = 36/143 (25%), Positives = 52/143 (36%), Gaps = 42/143 (29%)

Query: 630 SWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQW 689
           SW+ CS +CG G   R  RC ++  PG +   + D           E + C+ P C P  
Sbjct: 43  SWTRCSSSCGRGVSVRSRRCLRL--PG-EEPCWGD---------SHEYRLCQLPDCPP-- 88

Query: 690 EMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGP- 748
                          +V  RD++C+        N RPV      G     QW      P 
Sbjct: 89  --------------GAVPFRDLQCAL------YNGRPV-----LGTQKTYQWVPFHGAPN 123

Query: 749 -CSGSC-GQGRTIRHVYCKTSDG 769
            C  +C  +G    H + +  DG
Sbjct: 124 QCDLNCLAEGHAFYHSFGRVLDG 146


>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
           14 isoform 2 preproprotein [Homo sapiens]
          Length = 1223

 Score =  164 bits (414), Expect = 5e-40
 Identities = 95/287 (33%), Positives = 134/287 (46%), Gaps = 19/287 (6%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           W  WTK+ +CSRSCGGGV S+ R C        P  G R C G    YQ+C  +ECP   
Sbjct: 555 WSSWTKFGSCSRSCGGGVRSRSRSC----NNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 610

Query: 110 RSFREEQCVSFNSH-VYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVP--AR 166
             FR +QC   NS+ V+    H W P  PDD     ++ C+L C + D    + +     
Sbjct: 611 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDD----DAQKCELICQSADTGDVVFMNQVVH 666

Query: 167 DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
           DGT C   D   VC  G+C P+GCD  + S    DKCG+C GD S C  V G   K +  
Sbjct: 667 DGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQ 726

Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALADE-AGYYFFNGNYKVDSPKNFNIAGTVVK 285
            G   +  IPAGAR IQI   +KS   + + ++  G +  N   K  + + F   G   +
Sbjct: 727 AGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWE 786

Query: 286 YRRPMDVYETGIEYIVAQGPTNQGLNVMVW--NQNGKSPSITFEYTL 330
                D  E   E +   GP  + + ++     + G   S+ ++Y +
Sbjct: 787 -----DAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVI 828



 Score =  108 bits (271), Expect = 2e-23
 Identities = 91/291 (31%), Positives = 125/291 (42%), Gaps = 34/291 (11%)

Query: 564  DMYRWKLSSHEPCSATCTTGV-MSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC 622
            D Y W L S  PCS  C  G+  + Y    R D   V    CD   RP+P+   C    C
Sbjct: 847  DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 906

Query: 623  -QPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTC 680
             QP W T  W  CSR+CG+ G Q R ++C   LS G    + +  C      RPE R+ C
Sbjct: 907  SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD---RPEARRPC 963

Query: 681  RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQ 740
                C  QW +  WS+C+A CGE           + + +C  N   +G  +C G   DR 
Sbjct: 964  LRVPCPAQWRLGAWSQCSATCGE--------GIQQRQVVCRTNANSLG--HCEG---DRP 1010

Query: 741  WTVSDWG-PCSGSCGQGRTIRHVYCK--TSDGRVVPESQ-CQMETKPLAIHPC-GDKNCP 795
             TV     P  G   Q  T+R    +  T +G+ VP+S+      K  +  PC GD++  
Sbjct: 1011 DTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRS-- 1068

Query: 796  AHWLAQDWERCNTTCGRGVKKRL--VLCMELANGKPQTRSGPECGLAKKPP 844
               +    E  +  C      RL  V C++ A+G      GP+ G    PP
Sbjct: 1069 ---VFCQMEVLDRYCSIPGYHRLCCVSCIKKASG---PNPGPDPGPTSLPP 1113



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 62/250 (24%), Positives = 95/250 (38%), Gaps = 49/250 (19%)

Query: 740  QWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAI------HPCGDK 792
            +W +  W PCS +CG G       C+   D  +V    C  + +P  I      HPC   
Sbjct: 850  EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 909

Query: 793  NCPAHWLAQDWERCNTTCGR-GVKKRLVLCM-ELANGKPQTRSGPECGLAKKPPEESTCF 850
                 W+ ++W  C+ +CG+ GV+ R + C+  L+NG  +      C    +P     C 
Sbjct: 910  V----WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACA-GDRPEARRPCL 964

Query: 851  ERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC-- 907
              PC  +W    WS+C+ TCG G++ R V C    + +  C+   +P   Q C L  C  
Sbjct: 965  RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG-DRPDTVQVCSLPACGG 1023

Query: 908  --------------------------PTEPPDDSCQDQPGTN-----CALAIKVNLCGHW 936
                                      P  P +     +P T      C + +    C   
Sbjct: 1024 NHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIP 1083

Query: 937  YYSKACCRSC 946
             Y + CC SC
Sbjct: 1084 GYHRLCCVSC 1093



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 43/144 (29%), Positives = 58/144 (40%), Gaps = 15/144 (10%)

Query: 547  HKARTRPKARKQGVSPADMYRWKLSSHEPCSATC-TTGVMSAYAMCVR--YDGV-EVDDS 602
            HK R +P  R+    P     W       CS +C   GV +    C+    +G  +V  +
Sbjct: 890  HKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPA 949

Query: 603  YCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
               A  RPE     C    C  +W   +WS+CS TCGEG Q R V C             
Sbjct: 950  KACAGDRPE-ARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC----------RTN 998

Query: 663  SDLCEAAEAVRPEERKTCRNPACG 686
            ++     E  RP+  + C  PACG
Sbjct: 999  ANSLGHCEGDRPDTVQVCSLPACG 1022



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 16/95 (16%)

Query: 829 PQTRSGPECGLAKKPPEESTCF-----------ERPCFKWYTSPWSECTKTCGVGVRMRD 877
           P T  GP   LA K                   E   ++W    W+ C+K CG G++   
Sbjct: 812 PPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTK 871

Query: 878 VKCYQGTD--IVRG--CDPLVKPVG-RQACDLQPC 907
             C +  D  +V+   CD   +P   R+ C+  PC
Sbjct: 872 YGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 906



 Score = 30.8 bits (68), Expect = 6.3
 Identities = 25/93 (26%), Positives = 36/93 (38%), Gaps = 22/93 (23%)

Query: 837 CGLAKKPPEEST-------CFERPCFKWYT-----------SPWSE---CTKTCGVGVRM 875
           C   K PP + T       CF+  C  W +           S W++   C+++CG GVR 
Sbjct: 516 CKTKKGPPLDGTECAPGKWCFKGHCI-WKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRS 574

Query: 876 RDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 908
           R   C   +    G   L      Q C+ + CP
Sbjct: 575 RSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 607



 Score = 30.4 bits (67), Expect = 8.2
 Identities = 16/52 (30%), Positives = 22/52 (42%), Gaps = 13/52 (25%)

Query: 52  EWT--KWTACSRSCGGGVTSQERHCLQQR-----------RKSVPGPGNRTC 90
           EW    W  CS++CGGG+   +  C ++R            K  P P  R C
Sbjct: 850 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRC 901


>gi|110611167 ADAM metallopeptidase with thrombospondin type 1
           motif, 14 isoform 1 preproprotein [Homo sapiens]
          Length = 1226

 Score =  164 bits (414), Expect = 5e-40
 Identities = 95/287 (33%), Positives = 134/287 (46%), Gaps = 19/287 (6%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           W  WTK+ +CSRSCGGGV S+ R C        P  G R C G    YQ+C  +ECP   
Sbjct: 558 WSSWTKFGSCSRSCGGGVRSRSRSC----NNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 613

Query: 110 RSFREEQCVSFNSH-VYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVP--AR 166
             FR +QC   NS+ V+    H W P  PDD     ++ C+L C + D    + +     
Sbjct: 614 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDD----DAQKCELICQSADTGDVVFMNQVVH 669

Query: 167 DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
           DGT C   D   VC  G+C P+GCD  + S    DKCG+C GD S C  V G   K +  
Sbjct: 670 DGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQ 729

Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALADE-AGYYFFNGNYKVDSPKNFNIAGTVVK 285
            G   +  IPAGAR IQI   +KS   + + ++  G +  N   K  + + F   G   +
Sbjct: 730 AGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWE 789

Query: 286 YRRPMDVYETGIEYIVAQGPTNQGLNVMVW--NQNGKSPSITFEYTL 330
                D  E   E +   GP  + + ++     + G   S+ ++Y +
Sbjct: 790 -----DAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVI 831



 Score =  108 bits (271), Expect = 2e-23
 Identities = 91/291 (31%), Positives = 125/291 (42%), Gaps = 34/291 (11%)

Query: 564  DMYRWKLSSHEPCSATCTTGV-MSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC 622
            D Y W L S  PCS  C  G+  + Y    R D   V    CD   RP+P+   C    C
Sbjct: 850  DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 909

Query: 623  -QPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTC 680
             QP W T  W  CSR+CG+ G Q R ++C   LS G    + +  C      RPE R+ C
Sbjct: 910  SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD---RPEARRPC 966

Query: 681  RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQ 740
                C  QW +  WS+C+A CGE           + + +C  N   +G  +C G   DR 
Sbjct: 967  LRVPCPAQWRLGAWSQCSATCGE--------GIQQRQVVCRTNANSLG--HCEG---DRP 1013

Query: 741  WTVSDWG-PCSGSCGQGRTIRHVYCK--TSDGRVVPESQ-CQMETKPLAIHPC-GDKNCP 795
             TV     P  G   Q  T+R    +  T +G+ VP+S+      K  +  PC GD++  
Sbjct: 1014 DTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRS-- 1071

Query: 796  AHWLAQDWERCNTTCGRGVKKRL--VLCMELANGKPQTRSGPECGLAKKPP 844
               +    E  +  C      RL  V C++ A+G      GP+ G    PP
Sbjct: 1072 ---VFCQMEVLDRYCSIPGYHRLCCVSCIKKASG---PNPGPDPGPTSLPP 1116



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 62/250 (24%), Positives = 95/250 (38%), Gaps = 49/250 (19%)

Query: 740  QWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAI------HPCGDK 792
            +W +  W PCS +CG G       C+   D  +V    C  + +P  I      HPC   
Sbjct: 853  EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912

Query: 793  NCPAHWLAQDWERCNTTCGR-GVKKRLVLCM-ELANGKPQTRSGPECGLAKKPPEESTCF 850
                 W+ ++W  C+ +CG+ GV+ R + C+  L+NG  +      C    +P     C 
Sbjct: 913  V----WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACA-GDRPEARRPCL 967

Query: 851  ERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC-- 907
              PC  +W    WS+C+ TCG G++ R V C    + +  C+   +P   Q C L  C  
Sbjct: 968  RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG-DRPDTVQVCSLPACGG 1026

Query: 908  --------------------------PTEPPDDSCQDQPGTN-----CALAIKVNLCGHW 936
                                      P  P +     +P T      C + +    C   
Sbjct: 1027 NHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIP 1086

Query: 937  YYSKACCRSC 946
             Y + CC SC
Sbjct: 1087 GYHRLCCVSC 1096



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 43/144 (29%), Positives = 58/144 (40%), Gaps = 15/144 (10%)

Query: 547  HKARTRPKARKQGVSPADMYRWKLSSHEPCSATC-TTGVMSAYAMCVR--YDGV-EVDDS 602
            HK R +P  R+    P     W       CS +C   GV +    C+    +G  +V  +
Sbjct: 893  HKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPA 952

Query: 603  YCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
               A  RPE     C    C  +W   +WS+CS TCGEG Q R V C             
Sbjct: 953  KACAGDRPE-ARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC----------RTN 1001

Query: 663  SDLCEAAEAVRPEERKTCRNPACG 686
            ++     E  RP+  + C  PACG
Sbjct: 1002 ANSLGHCEGDRPDTVQVCSLPACG 1025



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 16/95 (16%)

Query: 829 PQTRSGPECGLAKKPPEESTCF-----------ERPCFKWYTSPWSECTKTCGVGVRMRD 877
           P T  GP   LA K                   E   ++W    W+ C+K CG G++   
Sbjct: 815 PPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTK 874

Query: 878 VKCYQGTD--IVRG--CDPLVKPVG-RQACDLQPC 907
             C +  D  +V+   CD   +P   R+ C+  PC
Sbjct: 875 YGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 909



 Score = 30.8 bits (68), Expect = 6.3
 Identities = 25/93 (26%), Positives = 36/93 (38%), Gaps = 22/93 (23%)

Query: 837 CGLAKKPPEEST-------CFERPCFKWYT-----------SPWSE---CTKTCGVGVRM 875
           C   K PP + T       CF+  C  W +           S W++   C+++CG GVR 
Sbjct: 519 CKTKKGPPLDGTECAPGKWCFKGHCI-WKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRS 577

Query: 876 RDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 908
           R   C   +    G   L      Q C+ + CP
Sbjct: 578 RSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 610



 Score = 30.4 bits (67), Expect = 8.2
 Identities = 16/52 (30%), Positives = 22/52 (42%), Gaps = 13/52 (25%)

Query: 52  EWT--KWTACSRSCGGGVTSQERHCLQQR-----------RKSVPGPGNRTC 90
           EW    W  CS++CGGG+   +  C ++R            K  P P  R C
Sbjct: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRC 904


>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif,
           3 proprotein [Homo sapiens]
          Length = 1205

 Score =  163 bits (413), Expect = 6e-40
 Identities = 100/290 (34%), Positives = 140/290 (48%), Gaps = 26/290 (8%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           WG WTK+ +CSR+CG GV  + R C       +P  G + C G +  YQLC  +EC    
Sbjct: 554 WGSWTKFGSCSRTCGTGVRFRTRQC----NNPMPINGGQDCPGVNFEYQLCNTEECQKHF 609

Query: 110 RSFREEQCVSFNSHV-YNGRTHQWKPL-YPDDYVHISSKPCDLHCTT-----VDGQRQLM 162
             FR +QC   NSH  Y    H W P  +PD       K C L+C +     V   +QL+
Sbjct: 610 EDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDP-----KKRCHLYCQSKETGDVAYMKQLV 664

Query: 163 VPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRK 222
               DGT C   D   +CV G+C  +GCD  + S    DKCG+C GD S C  V G + +
Sbjct: 665 ---HDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTR 721

Query: 223 GNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEA-GYYFFNGNYKVDSPKNFNIAG 281
               LGY  +  IP GAR + I E + S  +LA+ ++A G+Y  NG  +    + F   G
Sbjct: 722 TPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLG 781

Query: 282 TVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQ-NGKSPSITFEYTL 330
               Y       E  IE +   GP +  + V++  Q N    S+T++Y +
Sbjct: 782 VEWDYN-----IEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYII 826



 Score =  120 bits (302), Expect = 5e-27
 Identities = 81/274 (29%), Positives = 115/274 (41%), Gaps = 35/274 (12%)

Query: 501  ENEGAGPYLLNGSYLELSS---------------DRVANSSSEAPFPNVSTSLLTSAGNR 545
            +N+  G Y+LNG   E  S               D + +  ++ P  +    L+    N 
Sbjct: 756  KNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQEND 815

Query: 546  THKARTRPKARKQGVSPA-----------DMYRWKLSSHEPCSATCTTGVMSAYAMCVRY 594
            T  + T      +   P            D + W L S   CS  C  G       C R 
Sbjct: 816  TRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRK 875

Query: 595  -DGVEVDDSYCDALTRPEPVHEFCAGREC-QPRWETSSWSECSRTCG-EGYQFRVVRCWK 651
             D   V  S+C+A  +P+P+   C  +EC  P W    W  C++TCG  GYQ R VRC +
Sbjct: 876  SDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQ 935

Query: 652  MLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDI 711
             L  G + SV+S  C      RPE R+ C    C  QW+   WSEC+  CGE + V R +
Sbjct: 936  PLLDGTNRSVHSKYCMGD---RPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEV-RQV 991

Query: 712  RCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSD 745
             C   +  CD   +P   + C  PPC+ +  + D
Sbjct: 992  LCRAGDH-CD-GEKPESVRACQLPPCNDEPCLGD 1023



 Score =  119 bits (298), Expect = 1e-26
 Identities = 72/213 (33%), Positives = 97/213 (45%), Gaps = 16/213 (7%)

Query: 740  QWTVSDWGPCSGSCGQGRTIRHVYCKT-SDGRVVPESQCQMETKPLAIHP-CGDKNCPAH 797
            +W +  W  CS  CG G       C+  SD ++V  S C+   KP  I   C  + C   
Sbjct: 848  EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907

Query: 798  -WLAQDWERCNTTCGR-GVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC 854
             W+A++WE C  TCG  G + R V C++ L +G  ++     C +  +P     C   PC
Sbjct: 908  LWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC-MGDRPESRRPCNRVPC 966

Query: 855  -FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 913
              +W T PWSEC+ TCG G  +R V C  G      CD   KP   +AC L PC  EP  
Sbjct: 967  PAQWKTGPWSECSVTCGEGTEVRQVLCRAGDH----CDG-EKPESVRACQLPPCNDEP-- 1019

Query: 914  DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
              C       C + +    C    Y+K CC SC
Sbjct: 1020 --CLGDKSIFCQMEVLARYCSIPGYNKLCCESC 1050



 Score =  101 bits (252), Expect = 3e-21
 Identities = 58/182 (31%), Positives = 75/182 (41%), Gaps = 19/182 (10%)

Query: 626  WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
            W   SWS+CS+ CG G+Q+    C +      +  V+   CEA +  +P  R        
Sbjct: 849  WALKSWSQCSKPCGGGFQYTKYGCRRKSD---NKMVHRSFCEANKKPKPIRRMCNIQECT 905

Query: 686  GPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGP---------- 735
             P W   EW  CT  CG      R +RC +   L D   R V  K C G           
Sbjct: 906  HPLWVAEEWEHCTKTCGSSGYQLRTVRCLQP--LLDGTNRSVHSKYCMGDRPESRRPCNR 963

Query: 736  -PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD--GRVVPESQCQMETKPLAIHPC-GD 791
             PC  QW    W  CS +CG+G  +R V C+  D      PES    +  P    PC GD
Sbjct: 964  VPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGD 1023

Query: 792  KN 793
            K+
Sbjct: 1024 KS 1025



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 55/180 (30%), Positives = 74/180 (41%), Gaps = 25/180 (13%)

Query: 688  QWEMSEWSECTAKCGERSVVTR-DIRCSEDEKL-----CDPNTRPVG-EKNCTGPPCDRQ 740
            +W +  WS+C+  CG     T+   R   D K+     C+ N +P    + C    C   
Sbjct: 848  EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907

Query: 741  -WTVSDWGPCSGSCGQ-GRTIRHVYCKTS--DG--RVVPESQCQMETKPLAIHPCGDKNC 794
             W   +W  C+ +CG  G  +R V C     DG  R V    C M  +P +  PC    C
Sbjct: 908  LWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC-MGDRPESRRPCNRVPC 966

Query: 795  PAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC 854
            PA W    W  C+ TCG G + R VLC          R+G  C   +KP     C   PC
Sbjct: 967  PAQWKTGPWSECSVTCGEGTEVRQVLC----------RAGDHCD-GEKPESVRACQLPPC 1015



 Score = 35.8 bits (81), Expect = 0.20
 Identities = 20/62 (32%), Positives = 31/62 (50%), Gaps = 5/62 (8%)

Query: 851 ERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTD---IVRG-CDPLVKPVG-RQACDLQ 905
           E   F+W    WS+C+K CG G +     C + +D   + R  C+   KP   R+ C++Q
Sbjct: 843 ELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQ 902

Query: 906 PC 907
            C
Sbjct: 903 EC 904



 Score = 33.9 bits (76), Expect = 0.74
 Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 9/60 (15%)

Query: 52  EWT--KWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKR----YQLCRVQEC 105
           EW    W+ CS+ CGGG    +  C   RRKS     +R+    +K+     ++C +QEC
Sbjct: 848 EWALKSWSQCSKPCGGGFQYTKYGC---RRKSDNKMVHRSFCEANKKPKPIRRMCNIQEC 904



 Score = 31.2 bits (69), Expect = 4.8
 Identities = 29/119 (24%), Positives = 41/119 (34%), Gaps = 20/119 (16%)

Query: 837 CGLAKKPPEEST-------CFERPCF-----------KWYT-SPWSECTKTCGVGVRMRD 877
           C   K PP + T       C++  C             W + + +  C++TCG GVR R 
Sbjct: 516 CKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRT 575

Query: 878 VKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHW 936
            +C     I  G D        Q C+ + C     D   Q     N     + N   HW
Sbjct: 576 RQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQ-NTKHHW 633


>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
           motif, 8 preproprotein [Homo sapiens]
          Length = 889

 Score =  162 bits (411), Expect = 1e-39
 Identities = 101/296 (34%), Positives = 144/296 (48%), Gaps = 27/296 (9%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           W  W  W  CSR+CGGGV    R C    +   P  G R C G   +YQ C  +ECPPDG
Sbjct: 529 WAPWGPWGECSRTCGGGVQFSHREC----KDPEPQNGGRYCLGRRAKYQSCHTEECPPDG 584

Query: 110 RSFREEQCVSFNSHVY---NGRTHQWKPLYPDDYVHISSKP-CDLHCTTVDGQRQLMVPA 165
           +SFRE+QC  +N++ Y   +G   QW P     Y  +S +  C L C         +  A
Sbjct: 585 KSFREQQCEKYNAYNYTDMDGNLLQWVP----KYAGVSPRDRCKLFCRARGRSEFKVFEA 640

Query: 166 R--DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG 223
           +  DGT C    L  +CV G+C   GCD V+ S   LDKCG+C G G+SC  V+G+    
Sbjct: 641 KVIDGTLCGPETL-AICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPT 699

Query: 224 NAHLGYSLVTHIPAGARDIQIVER-----KKSADVLALADEAGYYFFNGNYKVDS-PKNF 277
           N   GY+ +  IPAGA +I + +R     +   + LAL    G Y  NGN  + +  ++ 
Sbjct: 700 N--YGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDI 757

Query: 278 NIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP 333
            + GT++KY   +      +E + +  P  + L V +    G+      +YT   P
Sbjct: 758 LVKGTILKYSGSI----ATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVP 809



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 22/65 (33%), Positives = 28/65 (43%), Gaps = 2/65 (3%)

Query: 731 NCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCG 790
           N   P    QW + DW  CS +CG G   R V C+   G+    + C    KP    PC 
Sbjct: 826 NIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQA--SATCNKALKPEDAKPCE 883

Query: 791 DKNCP 795
            + CP
Sbjct: 884 SQLCP 888



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 22/61 (36%), Positives = 31/61 (50%), Gaps = 8/61 (13%)

Query: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
           +W    WSECS TCG G+Q R V C     P   +S   +     +A++PE+ K C +  
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVEC---RDPSGQASATCN-----KALKPEDAKPCESQL 886

Query: 685 C 685
           C
Sbjct: 887 C 887



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 19/54 (35%), Positives = 28/54 (51%), Gaps = 1/54 (1%)

Query: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG-CDPLVKPVGRQACDLQPCP 908
           +W    WSEC+ TCG G + R V+C   +      C+  +KP   + C+ Q CP
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 19/59 (32%), Positives = 29/59 (49%), Gaps = 5/59 (8%)

Query: 796 AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC 854
           A W+  DW  C++TCG G ++R V C +     P  ++   C  A KP +   C  + C
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRD-----PSGQASATCNKALKPEDAKPCESQLC 887



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 16/50 (32%), Positives = 24/50 (48%)

Query: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTE 910
           PW EC++TCG GV+    +C        G   L +    Q+C  + CP +
Sbjct: 534 PWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPD 583



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 21/69 (30%), Positives = 30/69 (43%), Gaps = 7/69 (10%)

Query: 675 EERKTCR--NPACGPQWEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVG 728
           +ER T     P    QW + +WSEC++ CG     R+V  RD    +    C+   +P  
Sbjct: 820 KERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRD-PSGQASATCNKALKPED 878

Query: 729 EKNCTGPPC 737
            K C    C
Sbjct: 879 AKPCESQLC 887



 Score = 31.6 bits (70), Expect = 3.7
 Identities = 12/19 (63%), Positives = 12/19 (63%)

Query: 631 WSECSRTCGEGYQFRVVRC 649
           W ECSRTCG G QF    C
Sbjct: 535 WGECSRTCGGGVQFSHREC 553


>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
           10 preproprotein [Homo sapiens]
          Length = 1103

 Score =  162 bits (409), Expect = 2e-39
 Identities = 95/267 (35%), Positives = 129/267 (48%), Gaps = 16/267 (5%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           WG WT W  CSR+CGGGV+S  RHC   R    P  G + C G  +R++ C   +CPP  
Sbjct: 550 WGPWTPWGDCSRTCGGGVSSSSRHCDSPR----PTIGGKYCLGERRRHRSCNTDDCPPGS 605

Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTT--VDGQRQLMVPARD 167
           + FRE QC  F+S  + G+ ++WK      Y     K C L C     +   +      D
Sbjct: 606 QDFREVQCSEFDSIPFRGKFYKWKT-----YRGGGVKACSLTCLAEGFNFYTERAAAVVD 660

Query: 168 GTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHL 227
           GT C+  D   +CVSG+C+ +GCD VL S    DKC +C GDGS+C  + G +   +   
Sbjct: 661 GTPCR-PDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGA 719

Query: 228 GYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYR 287
           GY  V  IP G+  I I +   S   LAL  +       G      P    +AGT  + R
Sbjct: 720 GYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLR 779

Query: 288 RPMDVYETGIEYIVAQGPTNQGLNVMV 314
           +  D     ++ + A GP N  L VMV
Sbjct: 780 QGPD----QVQSLEALGPINASLIVMV 802



 Score =  146 bits (369), Expect = 8e-35
 Identities = 80/276 (28%), Positives = 120/276 (43%), Gaps = 20/276 (7%)

Query: 689  WEMSEWSECTAKC-GERSVVTRDIRCSEDEKLCDPN------TRPVGEKNCTGPPCDRQW 741
            W  + W++C+A+C G   V   + R   D     P+        P  ++ C   PC   W
Sbjct: 829  WHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDW 888

Query: 742  TVSDWGPCSGSCGQGRTIRHVYCK----TSDGRVVPESQCQMETKPLAIHPCGDKNCPAH 797
             V +W  CS SC  G   R V C+     ++ + + +S C  + +P  +  C    CP  
Sbjct: 889  VVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP-QPRPPVLEACHGPTCPPE 947

Query: 798  WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC--F 855
            W A DW  C  +CG G++ R+VLC    +    T     C  A KPP    C  R C   
Sbjct: 948  WAALDWSECTPSCGPGLRHRVVLCKSADHRA--TLPPAHCSPAAKPPATMRCNLRRCPPA 1005

Query: 856  KWYTSPWSECTKTCGVGVRMRDVKCYQGT-DIVRGCDPLVKPVGRQACDLQ---PCPTEP 911
            +W    W EC+  CGVG R R V+C   T      C   ++P   Q C+ +   P P + 
Sbjct: 1006 RWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDG 1065

Query: 912  PDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCR 947
            P++         C L +K   C   Y+ + CC++C+
Sbjct: 1066 PEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQ 1101



 Score =  116 bits (290), Expect = 1e-25
 Identities = 68/235 (28%), Positives = 94/235 (40%), Gaps = 13/235 (5%)

Query: 566  YRWKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 624
            Y W  +    CSA C  G       C  + D   V   YC A ++       C    C P
Sbjct: 827  YSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPP 886

Query: 625  RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
             W   +WS CSR+C  G + R V C + +S   + ++    C      RP   + C  P 
Sbjct: 887  DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQP---RPPVLEACHGPT 943

Query: 685  CGPQWEMSEWSECTAKCG----ERSVVTR--DIRCSEDEKLCDPNTRPVGEKNCTGPPC- 737
            C P+W   +WSECT  CG     R V+ +  D R +     C P  +P     C    C 
Sbjct: 944  CPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCP 1003

Query: 738  DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDK 792
              +W   +WG CS  CG G+  R V C +  G+     +C    +P     C  K
Sbjct: 1004 PARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQA--SHECTEALRPPTTQQCEAK 1056



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 57/180 (31%), Positives = 75/180 (41%), Gaps = 18/180 (10%)

Query: 568  WKLSSHEPCSATCTTGVMSAYAMCVRY----DGVEVDDSYCDALTRPEPVHEFCAGRECQ 623
            W + +   CS +C  GV S   +C R     +   +DDS C    RP PV E C G  C 
Sbjct: 888  WVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ-PRP-PVLEACHGPTCP 945

Query: 624  PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNP 683
            P W    WSEC+ +CG G + RVV C        D          + A +P     C   
Sbjct: 946  PEWAALDWSECTPSCGPGLRHRVVLC-----KSADHRATLPPAHCSPAAKPPATMRCNLR 1000

Query: 684  ACGP-QWEMSEWSECTAKCGERSVVTRDIRCS----EDEKLCDPNTRPVGEKNCTGPPCD 738
             C P +W   EW EC+A+CG      R +RC+    +    C    RP   + C    CD
Sbjct: 1001 RCPPARWVAGEWGECSAQCGV-GQRQRSVRCTSHTGQASHECTEALRPPTTQQCEA-KCD 1058



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 21/59 (35%), Positives = 25/59 (42%), Gaps = 5/59 (8%)

Query: 53  WTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTS---KRYQLCRVQECPPD 108
           +  WT CS  C GG   Q   C  Q   S   P    C+  S   KR + C  + CPPD
Sbjct: 831 YAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAP--HYCSAHSKLPKRQRACNTEPCPPD 887



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 5/63 (7%)

Query: 853 PCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTD----IVRGCDPLVK-PVGRQACDLQPC 907
           P + W+ +PW++C+  C  G +++ V+C    D        C    K P  ++AC+ +PC
Sbjct: 825 PPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPC 884

Query: 908 PTE 910
           P +
Sbjct: 885 PPD 887



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 15/54 (27%), Positives = 24/54 (44%)

Query: 860 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 913
           +PW +C++TCG GV      C      + G   L +    ++C+   CP    D
Sbjct: 554 TPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQD 607



 Score = 30.4 bits (67), Expect = 8.2
 Identities = 14/58 (24%), Positives = 24/58 (41%), Gaps = 2/58 (3%)

Query: 52   EWTK--WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPP 107
            EW    W+ C+ SCG G+  +   C     ++   P + +          C ++ CPP
Sbjct: 947  EWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPP 1004


>gi|110825974 ADAM metallopeptidase with thrombospondin type 1
           motif, 2 isoform 1 preproprotein [Homo sapiens]
          Length = 1211

 Score =  157 bits (398), Expect = 3e-38
 Identities = 97/286 (33%), Positives = 140/286 (48%), Gaps = 18/286 (6%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           WG W+ + +CSR+CG GV  + R C        P  G RTC+G +  +QLC  Q+CP   
Sbjct: 564 WGAWSPFGSCSRTCGTGVKFRTRQCDNPH----PANGGRTCSGLAYDFQLCSRQDCPDSL 619

Query: 110 RSFREEQCVSFNSHVYNGRT-HQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVP--AR 166
             FREEQC  ++ +  +G   H W P    D    + + C L+C + +    + +     
Sbjct: 620 ADFREEQCRQWDLYFEHGDAQHHWLPHEHRD----AKERCHLYCESRETGEVVSMKRMVH 675

Query: 167 DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
           DGT C   D   +CV G C  +GCDGV+ S+   DKCG+C GD S C  V G + +    
Sbjct: 676 DGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKK 735

Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALAD-EAGYYFFNGNYKVD-SPKNFNIAGTVV 284
            GY  +  IPAGAR + I E   ++  LA+ + E G +  N    VD S K F   G   
Sbjct: 736 HGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEW 795

Query: 285 KYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTL 330
           +YR      E G E +   GP +  + V+V        S+T++Y +
Sbjct: 796 EYRD-----EDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMI 836



 Score =  105 bits (261), Expect = 3e-22
 Identities = 63/182 (34%), Positives = 83/182 (45%), Gaps = 13/182 (7%)

Query: 565  MYRWKLSSHEPCSATCTTGVM-SAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC- 622
            +Y W L    PCS  C  G   + Y    R D   V   +C AL++P+ +   C  +EC 
Sbjct: 855  VYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECS 914

Query: 623  QPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR 681
            QP W T  W  CS+TCG  G Q R VRC + L      SV++  C  A   RPE R+ C 
Sbjct: 915  QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA---RPESRRACS 971

Query: 682  NPACGPQWEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPC 737
               C  +W    WS+C+  CG    ER V+    R ++D        RP   + C   PC
Sbjct: 972  RELCPGRWRAGPWSQCSVTCGNGTQERPVL---CRTADDSFGICQEERPETARTCRLGPC 1028

Query: 738  DR 739
             R
Sbjct: 1029 PR 1030



 Score =  103 bits (257), Expect = 8e-22
 Identities = 69/239 (28%), Positives = 98/239 (41%), Gaps = 34/239 (14%)

Query: 740  QWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAIH-PCGDKNCPAH 797
            +W +  W PCS  CG G       C+   D ++V    C   +KP AI   C  + C   
Sbjct: 857  EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916

Query: 798  -WLAQDWERCNTTCGR-GVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC 854
             W+  +WE C+ TCGR G++ R V C++ L +   ++     C  A+ P     C    C
Sbjct: 917  VWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDAR-PESRRACSRELC 975

Query: 855  -FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP----- 908
              +W   PWS+C+ TCG G + R V C    D    C    +P   + C L PCP     
Sbjct: 976  PGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQE-ERPETARTCRLGPCPRNISD 1034

Query: 909  -----------TEPPDDS----------CQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
                       + P  DS          CQ      C + +    C    Y+K CC+SC
Sbjct: 1035 PSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSC 1093



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 65/226 (28%), Positives = 88/226 (38%), Gaps = 34/226 (15%)

Query: 582  TGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEG 641
            T V   Y   +  D + VDD+  + L     V+E          W    WS CS+ CG G
Sbjct: 826  TRVSLTYKYMIHEDSLNVDDN--NVLEEDSVVYE----------WALKKWSPCSKPCGGG 873

Query: 642  YQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEE-RKTCRNPACG-PQWEMSEWSECTA 699
             QF    C + L       V+   C A    +P+  R+ C    C  P W   EW  C+ 
Sbjct: 874  SQFTKYGCRRRLD---HKMVHRGFCAALS--KPKAIRRACNPQECSQPVWVTGEWEPCSQ 928

Query: 700  KCGERSVVTRDIRC----------SEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPC 749
             CG   +  R +RC          S   K C+ + RP   + C+   C  +W    W  C
Sbjct: 929  TCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN-DARPESRRACSRELCPGRWRAGPWSQC 987

Query: 750  SGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCP 795
            S +CG G   R V C+T+D        CQ E +P     C    CP
Sbjct: 988  SVTCGNGTQERPVLCRTADDSF---GICQ-EERPETARTCRLGPCP 1029



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 5/58 (8%)

Query: 855 FKWYTSPWSECTKTCGVGVRMRDVKCYQGTD---IVRG-CDPLVKPVG-RQACDLQPC 907
           ++W    WS C+K CG G +     C +  D   + RG C  L KP   R+AC+ Q C
Sbjct: 856 YEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQEC 913



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 29/99 (29%), Positives = 37/99 (37%), Gaps = 25/99 (25%)

Query: 837 CGLAKKPPEEST-------CFERPCFKWYT-------------SPWSECTKTCGVGVRMR 876
           C   K PP + T       CF+  C  W T             SP+  C++TCG GV+ R
Sbjct: 526 CKTKKGPPLDGTMCAPGKHCFKGHCI-WLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFR 584

Query: 877 DVKC--YQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 913
             +C      +  R C  L      Q C  Q CP    D
Sbjct: 585 TRQCDNPHPANGGRTCSGLAYDF--QLCSRQDCPDSLAD 621



 Score = 31.2 bits (69), Expect = 4.8
 Identities = 24/77 (31%), Positives = 32/77 (41%), Gaps = 8/77 (10%)

Query: 32  NSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCT 91
           N   +N LE   D+  + W    KW+ CS+ CGGG    +  C  +RR          C 
Sbjct: 842 NVDDNNVLE--EDSVVYEWA-LKKWSPCSKPCGGGSQFTKYGC--RRRLDHKMVHRGFCA 896

Query: 92  GTSKRYQL---CRVQEC 105
             SK   +   C  QEC
Sbjct: 897 ALSKPKAIRRACNPQEC 913


>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
           motif, 5 preproprotein [Homo sapiens]
          Length = 930

 Score =  156 bits (395), Expect = 8e-38
 Identities = 93/249 (37%), Positives = 123/249 (49%), Gaps = 22/249 (8%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           WG W  W  CSRSCGGGV    RHC        P    R CTG    Y+ C +  CPP+G
Sbjct: 570 WGSWGSWGQCSRSCGGGVQFAYRHC----NNPAPRNNGRYCTGKRAIYRSCSLMPCPPNG 625

Query: 110 RSFREEQCVSFNSHVYNGRTH----QWKPLYPDDYVHISSKPCDLHCTTVD-GQRQLMVP 164
           +SFR EQC + N +  + +      +W P Y      + +  C L C     G   +  P
Sbjct: 626 KSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGV---LPADVCKLTCRAKGTGYYVVFSP 682

Query: 165 -ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG 223
              DGT C+L     VCV GKC   GCDG++ S    DKCG+C GD SSCT + G + K 
Sbjct: 683 KVTDGTECRLYS-NSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKK 741

Query: 224 NAHLGYSLVTHIPAGARDIQIVERK-----KSADVLALADEAGYYFFNGNYKVDSPKN-F 277
           +   GY+ V  IP GA  I++ + K     +    LAL  + G Y  NG Y + + +   
Sbjct: 742 SK--GYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETII 799

Query: 278 NIAGTVVKY 286
           +I GTV+ Y
Sbjct: 800 DINGTVMNY 808



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 1/53 (1%)

Query: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGT-DIVRGCDPLVKPVGRQACDLQPC 907
           +W T PW  C++TC  G   R V+C  G   + +GC    +P   + C L+ C
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930



 Score = 38.9 bits (89), Expect = 0.023
 Identities = 14/27 (51%), Positives = 17/27 (62%)

Query: 623 QPRWETSSWSECSRTCGEGYQFRVVRC 649
           QP+W T  W  CSRTC  G+  R V+C
Sbjct: 876 QPQWVTGPWLACSRTCDTGWHTRTVQC 902



 Score = 34.3 bits (77), Expect = 0.57
 Identities = 18/55 (32%), Positives = 22/55 (40%), Gaps = 2/55 (3%)

Query: 740 QWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNC 794
           QW    W  CS +C  G   R V C+  DG       C +  +P A   C  K C
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQ--DGNRKLAKGCPLSQRPSAFKQCLLKKC 930



 Score = 33.5 bits (75), Expect = 0.97
 Identities = 22/76 (28%), Positives = 33/76 (43%), Gaps = 9/76 (11%)

Query: 630 SWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQW 689
           SW +CSR+CG G QF    C    +P   ++     C    A+     ++C    C P  
Sbjct: 575 SWGQCSRSCGGGVQFAYRHC---NNPAPRNN--GRYCTGKRAI----YRSCSLMPCPPNG 625

Query: 690 EMSEWSECTAKCGERS 705
           +     +C AK G +S
Sbjct: 626 KSFRHEQCEAKNGYQS 641



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 17/65 (26%), Positives = 25/65 (38%), Gaps = 5/65 (7%)

Query: 790 GDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC 849
           G       W+   W  C+ TC  G   R V C +   G  +   G  C L+++P     C
Sbjct: 871 GSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQD---GNRKLAKG--CPLSQRPSAFKQC 925

Query: 850 FERPC 854
             + C
Sbjct: 926 LLKKC 930



 Score = 30.4 bits (67), Expect = 8.2
 Identities = 14/47 (29%), Positives = 21/47 (44%)

Query: 862 WSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 908
           W +C+++CG GV+     C        G     K    ++C L PCP
Sbjct: 576 WGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCP 622


>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
          Length = 1762

 Score =  154 bits (389), Expect = 4e-37
 Identities = 102/386 (26%), Positives = 158/386 (40%), Gaps = 75/386 (19%)

Query: 564 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC- 622
           D  +W      PC+ TC  G+     +C+ + G+      C   T+P    E      C 
Sbjct: 436 DCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG--CSPKTKPHIKEECIVPTPCY 493

Query: 623 -----------------------------QPRWETSSWSECSRTCGEGYQFRVVRCWKML 653
                                        +P +   +WS C+ TCG G Q R+VRC  +L
Sbjct: 494 KPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLL 553

Query: 654 SPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQ------------------------W 689
           S  F  SV     +  E  +P  ++ C    C  +                        W
Sbjct: 554 S--FSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDW 611

Query: 690 EMSEWSECTAKCG---ERSVVT---RDIRCSEDEKLCDPNTRPVGE-KNCTGPPCDRQWT 742
           E   +++C+  CG   + +VV+   +  R   +E LC  + RP    K+C   PC  +W 
Sbjct: 612 EYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWE 671

Query: 743 VSDWGPCSGSCGQGRTIRHVYC------KTSDGRVVPESQCQMETKPLAIHPCGDKNCPA 796
           +  W PCS +CG G   R V+C      + ++  ++ +  C+ + KP  +  C   NCP 
Sbjct: 672 IGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCR-QPKPSTVQACNRFNCPP 730

Query: 797 HWLAQDWERCNTTCGRGVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC- 854
            W    W+ C+ TCG GV+KR VLC + +A+G         C  A KP  +  C +  C 
Sbjct: 731 AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQACKKDDCP 789

Query: 855 FKWYTSPWSECTKTCGVGVRMRDVKC 880
            +W  S W+EC+ +CG G + R   C
Sbjct: 790 SEWLLSDWTECSTSCGEGTQTRSAIC 815



 Score =  132 bits (332), Expect = 2e-30
 Identities = 88/287 (30%), Positives = 131/287 (45%), Gaps = 29/287 (10%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           W  W  W+ CSR+CGGG +   R CL           +++C G + RY+ C   +CPP+ 
Sbjct: 36  WDAWGPWSECSRTCGGGASYSLRRCLS----------SKSCEGRNIRYRTCSNVDCPPEA 85

Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQR--QLMVPARD 167
             FR +QC + N   ++G+ ++W P+  D        PC L C         +L     D
Sbjct: 86  GDFRAQQCSAHNDVKHHGQFYEWLPVSNDP-----DNPCSLKCQAKGTTLVVELAPKVLD 140

Query: 168 GTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG-NAH 226
           GT C  T+   +C+SG C+ +GCD  L ST   D CG+C GDGS+C  V G Y+   +A 
Sbjct: 141 GTRC-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSAT 199

Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKY 286
                V  IP G+R I++V   K  D L L  +       G   + S   F +  + V +
Sbjct: 200 KSDDTVVAIPYGSRHIRLV--LKGPDHLYLETKT-LQGTKGENSLSSTGTFLVDNSSVDF 256

Query: 287 RRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP 333
           ++  D      E +   GP      V +  +N  S   T ++   QP
Sbjct: 257 QKFPDK-----EILRMAGPLTADFIVKI--RNSGSADSTVQFIFYQP 296



 Score =  128 bits (321), Expect = 3e-29
 Identities = 83/278 (29%), Positives = 119/278 (42%), Gaps = 36/278 (12%)

Query: 566  YRWKLSSHEPCSATC-TTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 624
            Y W +     CSA+C   GV      C+  +  EV+ ++C    RP      C  R+C  
Sbjct: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCL-LNSTEVNPAHCAGKVRPAVQPIACNRRDCPS 1547

Query: 625  RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
            RW  +SWS C+R+CG G Q R V C K+ + G  + V +D+C    A RP + + C    
Sbjct: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQV-AKRPVDTQACNQQL 1606

Query: 685  CGPQWEMSEWSECTAKC--GERSVVTRDIRCSEDEKL------CDPNTRPVGEKNCTGPP 736
            C  +W  S W +C   C     +V  R + C   + +      C    RPV  +NC    
Sbjct: 1607 C-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEA 1665

Query: 737  CDRQWTVSDWGPCSGSCG----QGRTIRHVYCKTSDGRVVPESQCQMETKP-----LAIH 787
            C   W VS W  C+ +CG    Q R +  V+ +T+  + VPE  C    +P       I 
Sbjct: 1666 CSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTN--KAVPEHLCSWGPRPANWQRCNIT 1723

Query: 788  PCGDKNC-------------PAHWLAQDWERCNTTCGR 812
            PC +  C                 L+Q   RC  TCG+
Sbjct: 1724 PCENMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCGK 1761



 Score =  126 bits (316), Expect = 1e-28
 Identities = 108/427 (25%), Positives = 159/427 (37%), Gaps = 79/427 (18%)

Query: 560 VSPADMY----RWKLSSHEPCSATCTTGVMSAYAMCVRYD----GVEVDDSYCDALTRPE 611
           + P D+Y    RW+ +    CS++C  G+ S    CV  D       V++  C   T   
Sbjct: 368 IMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC-MYTPKM 426

Query: 612 PVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKM-------LSPGFDSSVYSD 664
           P+ + C   +C P+W    WS C+ TCG+G ++RVV C           SP     +  +
Sbjct: 427 PIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEE 485

Query: 665 LCEAAEAVRPEER----------KTCRNPACG------PQWEMSEWSECTAKCGERSVVT 708
                   +P+E+          K  +    G      P +    WS CT  CG  + V 
Sbjct: 486 CIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQV- 544

Query: 709 RDIRC----SEDEKLCD------PNTRPVGEKNCTGPPCDRQ------------------ 740
           R +RC    S  + + D         +P  ++ C   PC  +                  
Sbjct: 545 RIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQD 604

Query: 741 ------WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETK--PLAIHPCGDK 792
                 W    +  CS SCG G     V C     R   E    + ++  P  +  C   
Sbjct: 605 FDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLD 664

Query: 793 NCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRS--GPECGLAKKPPEESTCF 850
            CPA W    W  C+ TCG G++ R V C  L + +         E     KP     C 
Sbjct: 665 PCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACN 724

Query: 851 ERPCFK-WYTSPWSECTKTCGVGVRMRDVKCYQG------TDIVRGCDPLVKPVGRQACD 903
              C   WY + W  C++TCG GV+ R+V C Q        ++        KP  +QAC 
Sbjct: 725 RFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACK 784

Query: 904 LQPCPTE 910
              CP+E
Sbjct: 785 KDDCPSE 791



 Score =  122 bits (306), Expect = 2e-27
 Identities = 115/440 (26%), Positives = 174/440 (39%), Gaps = 104/440 (23%)

Query: 565 MYRWKLSSHEPCSATCTTGVMSAYAMC--VRYDGVEVDDSYCDALT---RPEPVHEFCAG 619
           ++RW+ +   PCSATC  G     A C  +R + V V D YC       +P+P  + C  
Sbjct: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRV-VADQYCHYYPENIKPKPKLQECNL 356

Query: 620 RECQ-----------------PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
             C                  PRWE + W+ CS +CG G Q R V C +    G  +SV 
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416

Query: 663 SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL--- 719
              C      +    + C    C P+W   EWS CT  CG+  +  R + C +   +   
Sbjct: 417 EWKC--MYTPKMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQ-GLRYRVVLCIDHRGMHTG 472

Query: 720 -CDPNTRPVGEKNCTGP-PCDR-----------QW-----------TVSD--------WG 747
            C P T+P  ++ C  P PC +            W            VS+        W 
Sbjct: 473 GCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWS 532

Query: 748 PCSGSCGQGRTIRHVYCK-----TSDGRVVPESQCQMETKPLAIHPCGDKNCPAH----- 797
            C+ +CG G  +R V C+     +     +P  +C+   KP +   C    C        
Sbjct: 533 ACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECE-GPKPASQRACYAGPCSGEIPEFN 591

Query: 798 -------------------WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECG 838
                              W  + + +C+ +CG GV++ +V C+     +P   +   C 
Sbjct: 592 PDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEEN--LCV 649

Query: 839 LAKKPPE-ESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKC-----YQGTDIVRGCD 891
            +++PP+   +C   PC  +W    WS C+ TCGVG++ RDV C      +  + V   D
Sbjct: 650 TSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILAD 709

Query: 892 PLV---KPVGRQACDLQPCP 908
            L    KP   QAC+   CP
Sbjct: 710 ELCRQPKPSTVQACNRFNCP 729



 Score =  119 bits (299), Expect = 1e-26
 Identities = 73/248 (29%), Positives = 104/248 (41%), Gaps = 22/248 (8%)

Query: 564 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALTRPEPVHEFCAGREC 622
           ++Y W+      CS +C  GV  A   C+     E  +++ C    RP  + + C    C
Sbjct: 607 ELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPC 666

Query: 623 QPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY--SDLCEAAEAVRPEERKTC 680
             RWE   WS CS TCG G Q R V C  +LS   + +V    +LC      +P   + C
Sbjct: 667 PARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQP---KPSTVQAC 723

Query: 681 RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSE----------DEKLCDPNTRPVGEK 730
               C P W  ++W  C+  CG   V  R++ C +           E  C   ++P  ++
Sbjct: 724 NRFNCPPAWYPAQWQPCSRTCG-GGVQKREVLCKQRMADGSFLELPETFCSA-SKPACQQ 781

Query: 731 NCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC----KTSDGRVVPESQCQMETKPLAI 786
            C    C  +W +SDW  CS SCG+G   R   C    KT    VV  + C       +I
Sbjct: 782 ACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSI 841

Query: 787 HPCGDKNC 794
            PC    C
Sbjct: 842 RPCMLATC 849



 Score =  118 bits (296), Expect = 2e-26
 Identities = 76/246 (30%), Positives = 110/246 (44%), Gaps = 29/246 (11%)

Query: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
           WE   +++CS +CG G Q  VV C   L+         +LC  +    P+  K+C    C
Sbjct: 611 WEYEGFTKCSESCGGGVQEAVVSC---LNKQTREPAEENLCVTSRRP-PQLLKSCNLDPC 666

Query: 686 GPQWEMSEWSECTAKCGERSVVTRDIRCSE------------DEKLCDPNTRPVGEKNCT 733
             +WE+ +WS C+  CG   + TRD+ CS              ++LC    +P   + C 
Sbjct: 667 PARWEIGKWSPCSLTCGV-GLQTRDVFCSHLLSREMNETVILADELCR-QPKPSTVQACN 724

Query: 734 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT--SDGRVV--PESQCQMETKPLAIHPC 789
              C   W  + W PCS +CG G   R V CK   +DG  +  PE+ C   +KP     C
Sbjct: 725 RFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSA-SKPACQQAC 783

Query: 790 GDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEEST 848
              +CP+ WL  DW  C+T+CG G + R  +C + L  G     +   C     PP   +
Sbjct: 784 KKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLC-----PPLPFS 838

Query: 849 CFERPC 854
              RPC
Sbjct: 839 SSIRPC 844



 Score =  104 bits (260), Expect = 3e-22
 Identities = 90/340 (26%), Positives = 126/340 (37%), Gaps = 85/340 (25%)

Query: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
           RW  + +  CS TCG GYQ     C+ + S    +  Y       E ++P+         
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYP--ENIKPK--------- 348

Query: 685 CGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVS 744
             P+ +      C A  G + ++  D        L  P  R               W  +
Sbjct: 349 --PKLQECNLDPCPASDGYKQIMPYD--------LYHPLPR---------------WEAT 383

Query: 745 DWGPCSGSCGQGRTIRHVYCKTSD--GRV--VPESQCQMETKPLAIHPCGDKNCPAHWLA 800
            W  CS SCG G   R V C   D  G V  V E +C    K     PC   +CP  WLA
Sbjct: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLA 442

Query: 801 QDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCF-ERPCFK--- 856
           Q+W  C  TCG+G++ R+VLC++    +     G  C    KP  +  C    PC+K   
Sbjct: 443 QEWSPCTVTCGQGLRYRVVLCID---HRGMHTGG--CSPKTKPHIKEECIVPTPCYKPKE 497

Query: 857 ---------WYTSP-------------------WSECTKTCGVGVRMRDVKCYQGTDIVR 888
                    W+                      WS CT TCGVG ++R V+C       +
Sbjct: 498 KLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQ 557

Query: 889 GCDPLV-------KPVGRQACDLQPCPTEPPDDSCQDQPG 921
               L        KP  ++AC   PC  E P+ +  +  G
Sbjct: 558 SVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDG 597



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 75/283 (26%), Positives = 109/283 (38%), Gaps = 39/283 (13%)

Query: 689  WEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDP-----NTRPVGEK-NCTGPPCDRQWT 742
            W +   + C+A CG R V    +RC  +    +P       RP  +   C    C  +W 
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550

Query: 743  VSDWGPCSGSCGQGRTIRHVYCKT--SDGRVVPESQ---CQMETKPLAIHPCGDKNCPAH 797
            V+ W  C+ SCG G   R V C+   + G   P S     Q+  +P+    C  + C   
Sbjct: 1551 VTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC-VE 1609

Query: 798  WLAQDWERCNTTC---GRGVKKRLVLCMELANGKPQTRSG-----PECGLAKKPPEESTC 849
            W    W +CN  C      V+ R V C        QTR G      +C    +P     C
Sbjct: 1610 WAFSSWGQCNGPCIGPHLAVQHRQVFC--------QTRDGITLPSEQCSALPRPVSTQNC 1661

Query: 850  FERPC-FKWYTSPWSECTKTCG-VGVRMRDVKCYQGTDIVRGCDPLV----KPVGRQACD 903
            +   C   W  S W+ CT TCG  G + R V+C          + L     +P   Q C+
Sbjct: 1662 WSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCN 1721

Query: 904  LQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
            + PC     +  C+D     C    ++ LC    +   CC +C
Sbjct: 1722 ITPC----ENMECRDTT-RYCEKVKQLKLCQLSQFKSRCCGTC 1759



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 60/204 (29%), Positives = 83/204 (40%), Gaps = 27/204 (13%)

Query: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQ-----METKPLAIHPC 789
           P   +W  +D+ PCS +CG G  +    C      RVV +  C      ++ KP  +  C
Sbjct: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKP-KLQEC 354

Query: 790 GDKNCPA-----------------HWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQT 831
               CPA                  W A  W  C+++CG G++ R V C+E    G   +
Sbjct: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTS 414

Query: 832 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDI-VRGC 890
               +C    K P    C    C KW    WS CT TCG G+R R V C     +   GC
Sbjct: 415 VEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474

Query: 891 DPLVKPVGRQACDLQPCPTEPPDD 914
            P  KP  ++ C + P P   P +
Sbjct: 475 SPKTKPHIKEEC-IVPTPCYKPKE 497



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 56/181 (30%), Positives = 83/181 (45%), Gaps = 13/181 (7%)

Query: 738  DRQWTVSDWGPCSGSCG-QGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP--CGDKNC 794
            D  W+V     CS SCG +G     + C  +   V P + C  + +P A+ P  C  ++C
Sbjct: 1488 DYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNP-AHCAGKVRP-AVQPIACNRRDC 1545

Query: 795  PAHWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQTRSGPEC-GLAKKPPEESTCFER 852
            P+ W+   W  C  +CG GV+ R V C +L A+G     S   C  +AK+P +   C ++
Sbjct: 1546 PSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQ 1605

Query: 853  PCFKWYTSPWSECTKTC---GVGVRMRDVKCYQGTDIV---RGCDPLVKPVGRQACDLQP 906
             C +W  S W +C   C    + V+ R V C     I      C  L +PV  Q C  + 
Sbjct: 1606 LCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEA 1665

Query: 907  C 907
            C
Sbjct: 1666 C 1666



 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 43/123 (34%), Positives = 62/123 (50%), Gaps = 9/123 (7%)

Query: 568 WKLSSHEPCSATCTTGVMSAYAMCVRY--DG--VEVDDSYCDALTRPEPVHEFCAGRECQ 623
           W  +  +PCS TC  GV     +C +   DG  +E+ +++C A ++P    + C   +C 
Sbjct: 732 WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSA-SKPA-CQQACKKDDCP 789

Query: 624 PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA---AEAVRPEERKTC 680
             W  S W+ECS +CGEG Q R   C KML  G  + V S LC     + ++RP    TC
Sbjct: 790 SEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATC 849

Query: 681 RNP 683
             P
Sbjct: 850 ARP 852



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 22/56 (39%), Positives = 30/56 (53%), Gaps = 4/56 (7%)

Query: 54   TKWTACSRSCGGGVTSQERHCLQQRRKSVPGP-GNRTCTGTSKR---YQLCRVQEC 105
            T W+AC+RSCGGGV ++   C + +   +  P  N  CT  +KR    Q C  Q C
Sbjct: 1552 TSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 22/58 (37%), Positives = 30/58 (51%), Gaps = 3/58 (5%)

Query: 52  EWTKWTACSRSCGGGVTSQERHCLQQR-RKSVPGPGNRTCTGTSKR--YQLCRVQECP 106
           E T WTACS SCGGG+ S+   C+++  +  V       C  T K    Q C + +CP
Sbjct: 381 EATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438



 Score = 37.4 bits (85), Expect = 0.067
 Identities = 23/69 (33%), Positives = 30/69 (43%), Gaps = 15/69 (21%)

Query: 631 WSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWE 690
           WSECSRTCG G  + + RC           + S  CE     R    +TC N  C P+  
Sbjct: 42  WSECSRTCGGGASYSLRRC-----------LSSKSCEG----RNIRYRTCSNVDCPPEAG 86

Query: 691 MSEWSECTA 699
                +C+A
Sbjct: 87  DFRAQQCSA 95



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 24/80 (30%), Positives = 35/80 (43%), Gaps = 8/80 (10%)

Query: 32  NSPTSNSLEGGT-DATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTC 90
           N   ++ L GG  D    +  E+  +T CS SCGGGV      CL ++ +    P     
Sbjct: 591 NPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTRE---PAEENL 647

Query: 91  TGTSKR----YQLCRVQECP 106
             TS+R     + C +  CP
Sbjct: 648 CVTSRRPPQLLKSCNLDPCP 667



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 19/56 (33%), Positives = 26/56 (46%), Gaps = 2/56 (3%)

Query: 55  KWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKR--YQLCRVQECPPD 108
           +W  CSR+CGGGV  +E  C Q+           T    SK    Q C+  +CP +
Sbjct: 736 QWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSE 791



 Score = 32.3 bits (72), Expect = 2.2
 Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 6/57 (10%)

Query: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQ 917
           PWSEC++TCG G      +C       + C+   + +  + C    CP E  D   Q
Sbjct: 41  PWSECSRTCGGGASYSLRRCLSS----KSCEG--RNIRYRTCSNVDCPPEAGDFRAQ 91


>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
           sapiens]
          Length = 877

 Score =  152 bits (384), Expect = 1e-36
 Identities = 86/247 (34%), Positives = 131/247 (53%), Gaps = 9/247 (3%)

Query: 90  CTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCD 149
           C+G S++ + C    CPP+    R  QC +FNS  + G+ +QW+P          S+ C+
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQ----GSQRCE 419

Query: 150 LHCTTVDGQRQLM--VPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQ 207
           L+C     +  +      +DGT C+      +CV+G+C   GCDG+L S    D CG+C 
Sbjct: 420 LNCRPRGFRFYVRHTEKVQDGTLCQ-PGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478

Query: 208 GDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNG 267
           GD S+C  V+GN       LGY  +  IPAGA  +QI + + S++ LAL    G    NG
Sbjct: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIING 538

Query: 268 NYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFE 327
           N+ VD P ++   GTV +Y RP      G E + A+GPT Q ++V +  Q  ++P + ++
Sbjct: 539 NWAVDPPGSYRAGGTVFRYNRPPREEGKG-ESLSAEGPTTQPVDVYMIFQE-ENPGVFYQ 596

Query: 328 YTLLQPP 334
           Y +  PP
Sbjct: 597 YVISSPP 603



 Score =  115 bits (287), Expect = 3e-25
 Identities = 69/189 (36%), Positives = 91/189 (48%), Gaps = 16/189 (8%)

Query: 568 WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
           WK   H  CSA+C  GV     +C+ R  G E+D+  C A  RP    E C G  C P W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727

Query: 627 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACG 686
           E   W+ CSR+CG G Q R ++C +    G  SSV  + C      RP   ++C+   CG
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGG-GSSVPPERC--GHLPRPNITQSCQLRLCG 784

Query: 687 PQWEM-SEWSECTAKCGERSVVTRDIRC--------SEDEKLCDPNTRPVGEKNCTGPPC 737
             WE+ S WS+C+ +CG R   +R +RC        SE E    P  +P   + C   PC
Sbjct: 785 -HWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGP-PQPPSREACDMGPC 841

Query: 738 DRQWTVSDW 746
              W  SDW
Sbjct: 842 TTAWFHSDW 850



 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 60/196 (30%), Positives = 83/196 (42%), Gaps = 20/196 (10%)

Query: 741 WTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQMETKPLAI-HPCGDKNCPAHW 798
           W       CS SCG+G       C + + G  + E  C    +P A   PC    CP +W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727

Query: 799 LAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWY 858
            A +W  C+ +CG G + R + C +   G   +     CG   +P    +C  R C  W 
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787

Query: 859 T-SPWSECTKTCGVGVRMRDVKCY--QGTDIVRG--CDPLVKPVGRQACDLQPCPT---- 909
             SPWS+C+  CG G R R V+C    G ++          +P  R+ACD+ PC T    
Sbjct: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFH 847

Query: 910 ---------EPPDDSC 916
                    EPP  SC
Sbjct: 848 SDWSSKVSPEPPAISC 863



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 63/206 (30%), Positives = 88/206 (42%), Gaps = 25/206 (12%)

Query: 674 PEERKTCRNPACGPQWEMSEWSECTAKCGE---RSV---VTRDIRCSEDEKLCDPNTRP- 726
           P  R    +PA    W+    S C+A CG+   R +   ++R+     DE+ C    RP 
Sbjct: 655 PHPRTPLGSPAA--YWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPP 712

Query: 727 VGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT---SDGRVVPESQCQMETKP 783
              + C G PC   W   +W  CS SCG G   R + C+      G  VP  +C    +P
Sbjct: 713 ASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRP 772

Query: 784 LAIHPCGDKNCPAHW-LAQDWERCNTTCGRGVKKRLVLCMELANG----KPQTRSGPECG 838
                C  + C  HW +   W +C+  CGRG + R V C+   NG    + +  SGP   
Sbjct: 773 NITQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECASGP--- 827

Query: 839 LAKKPPEESTCFERPC-FKWYTSPWS 863
              +PP    C   PC   W+ S WS
Sbjct: 828 --PQPPSREACDMGPCTTAWFHSDWS 851



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 23/165 (13%)

Query: 774 ESQCQMETKPLAIHPCGDKNCPA-HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTR 832
           + Q ++   P   HP      PA +W       C+ +CG+GV + + LC+   +G+    
Sbjct: 643 QRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDE 702

Query: 833 SGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD 891
                G A+ P     C   PC   W    W+ C+++CG G + R ++C Q         
Sbjct: 703 RSCAAG-ARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ--------- 752

Query: 892 PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHW 936
                      +     +  P + C   P  N   + ++ LCGHW
Sbjct: 753 -----------EFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHW 786



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 8/73 (10%)

Query: 5  WQCSCWAWFLLVLAV---VAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSR 61
          W    W + LL+L++        V +G +  +PT      G +     WG W +W +CS+
Sbjct: 4  WTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQ--GPEGV---WGPWVQWASCSQ 58

Query: 62 SCGGGVTSQERHC 74
           CG GV  + R C
Sbjct: 59 PCGVGVQRRSRTC 71



 Score = 37.4 bits (85), Expect = 0.067
 Identities = 21/66 (31%), Positives = 26/66 (39%), Gaps = 1/66 (1%)

Query: 568 WKLSSH-EPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
           W++ S    CS  C  G  S    CV  +G EV +  C +     P  E C    C   W
Sbjct: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAW 845

Query: 627 ETSSWS 632
             S WS
Sbjct: 846 FHSDWS 851



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 2/55 (3%)

Query: 23  DTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQ 77
           D  S  +    P S     GT    +W  E  +WT+CSRSCG G   ++  C Q+
Sbjct: 701 DERSCAAGARPPASPEPCHGTPCPPYW--EAGEWTSCSRSCGPGTQHRQLQCRQE 753


>gi|145309328 papilin [Homo sapiens]
          Length = 1251

 Score =  150 bits (379), Expect = 5e-36
 Identities = 96/305 (31%), Positives = 147/305 (48%), Gaps = 56/305 (18%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           WG W++W+ CSR+CGGGV+ +ER C  QRR      G  +C G ++ ++ CR + CP   
Sbjct: 29  WGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-----GGSSCVGPARSHRSCRTESCPDGA 83

Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQ-----RQLMVP 164
           R FR EQC  F+   + GR ++W P Y       +   C+L+C           R+ +V 
Sbjct: 84  RDFRAEQCAEFDGAEFQGRRYRWLPYYS------APNKCELNCIPKGENFYYKHREAVV- 136

Query: 165 ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGN 224
             DGT C+    R VCV G C  +GCD  L S+   DKC  C GDG++C  V G +    
Sbjct: 137 --DGTPCE-PGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTF---- 189

Query: 225 AHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVV 284
                         A D+            A+ +  G Y+ NG++ +++ +    A T++
Sbjct: 190 -------------DANDLS----------RAVKNVRGEYYLNGHWTIEAARALPAASTIL 226

Query: 285 KYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYY 344
            Y R  +  +   E + A+GPT++ L + + +Q   +P + +EY L       RP P   
Sbjct: 227 HYERGAE-GDLAPERLHARGPTSEPLVIELISQE-PNPGVHYEYHL----PLRRPSP--- 277

Query: 345 GFSES 349
           GFS S
Sbjct: 278 GFSWS 282



 Score =  144 bits (364), Expect = 3e-34
 Identities = 90/276 (32%), Positives = 120/276 (43%), Gaps = 24/276 (8%)

Query: 667 EAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEK-----LCD 721
           E    V  E     R P+ G  W    WS+C+A+CG     +R + C+ D +     +C 
Sbjct: 259 EPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQ-SRLVFCTIDHEAYPDHMCQ 317

Query: 722 PNTRPVGEKNCTGPPCD--RQWTVSDWGPCSGSCGQGRTIRHVYCKTSDG----RVVPES 775
              RP   ++C   PC   ++W    W PCS SCG G   R VYC +SDG      V E+
Sbjct: 318 RQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEA 377

Query: 776 QCQ-METKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSG 834
           +C  +  KP AI  C  + C A W  + W  C+ +CG GV+KR V C         T + 
Sbjct: 378 ECAGLPGKPPAIQACNLQRCAA-WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAA- 435

Query: 835 PECGLAKKPPEESTCFERPC-----FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG 889
             C L  +PP    C    C       W+   W  C+K+C  G R R V C  G     G
Sbjct: 436 --CSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCG 493

Query: 890 CDPLVKPVGRQACDLQPC--PTEPPDDSCQDQPGTN 923
                KPV  + C+ QPC  P E P       P +N
Sbjct: 494 SLQHSKPVDVEPCNTQPCHLPQEVPSMQDVHTPASN 529



 Score =  114 bits (286), Expect = 3e-25
 Identities = 76/250 (30%), Positives = 109/250 (43%), Gaps = 40/250 (16%)

Query: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSD-LCEAAEAVRPEERKTCRNPA 684
           W   SWS+CS  CG G+Q R+V C        D   Y D +C+     RP +R++C    
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFC------TIDHEAYPDHMCQ--RQPRPADRRSCNLHP 332

Query: 685 C--GPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPP------ 736
           C    +W+   W+ C+A CG  S  +R + C   +         V E  C G P      
Sbjct: 333 CPETKRWKAGPWAPCSASCGGGS-QSRSVYCISSDGA--GIQEAVEEAECAGLPGKPPAI 389

Query: 737 --CDRQ----WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCG 790
             C+ Q    W+   WG CS SCG G   R V C+   G ++  + C +E +P    PC 
Sbjct: 390 QACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV 449

Query: 791 DKNCP----AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAK--KPP 844
            ++CP      W    W  C+ +C  G ++R V+C   A G P       CG  +  KP 
Sbjct: 450 HEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVIC---AIGPPS-----HCGSLQHSKPV 501

Query: 845 EESTCFERPC 854
           +   C  +PC
Sbjct: 502 DVEPCNTQPC 511



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 74/246 (30%), Positives = 91/246 (36%), Gaps = 22/246 (8%)

Query: 562 PADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRE 621
           P+  + W   S   CSA C  G  S    C   D     D  C    RP      C    
Sbjct: 275 PSPGFSWSHGSWSDCSAECGGGHQSRLVFCT-IDHEAYPDHMCQRQPRPAD-RRSCNLHP 332

Query: 622 CQP--RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKT 679
           C    RW+   W+ CS +CG G Q R V C      G   +V    C A    +P   + 
Sbjct: 333 CPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAEC-AGLPGKPPAIQA 391

Query: 680 CRNPACGPQWEMSEWSECTAKCG----ERSVVTRDIRCS-EDEKLCDPNTRPVGEKNCTG 734
           C    C   W    W EC+  CG    +RSV  R  R S      C    RP   + C  
Sbjct: 392 CNLQRCA-AWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVH 450

Query: 735 PPC----DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQC--QMETKPLAIHP 788
             C    D+ W V  WG CS SC  G   R V C      + P S C     +KP+ + P
Sbjct: 451 EDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVIC-----AIGPPSHCGSLQHSKPVDVEP 505

Query: 789 CGDKNC 794
           C  + C
Sbjct: 506 CNTQPC 511



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 104/456 (22%), Positives = 149/456 (32%), Gaps = 91/456 (19%)

Query: 553 PKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCV--RYDGVEVDDSYCDALTRP 610
           PK R+Q  +     +W      PCS TC  GV      C   R DG     S C     P
Sbjct: 20  PKVRRQSDTWGPWSQWS-----PCSRTCGGGVSFRERPCYSQRRDG----GSSC---VGP 67

Query: 611 EPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVR----------CWKMLSPGFDSS 660
              H  C    C          +C+   G  +Q R  R          C     P  ++ 
Sbjct: 68  ARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENF 127

Query: 661 VYSDLCEAAEAVRPEERK-------TCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRC 713
            Y       +    E  K       +CR   C  + + S+  +   +CG          C
Sbjct: 128 YYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTT-----C 182

Query: 714 SEDEKLCDPNTRPVGEKNCTGP-PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVV 772
                  D N      KN  G    +  WT+      + +     TI H Y + ++G + 
Sbjct: 183 YPVAGTFDANDLSRAVKNVRGEYYLNGHWTIE----AARALPAASTILH-YERGAEGDLA 237

Query: 773 PESQCQM--ETKPLAIHPCGDKNCPA----------------HWLAQDWERCNTTCGRGV 814
           PE        ++PL I     +  P                  W    W  C+  CG G 
Sbjct: 238 PERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGH 297

Query: 815 KKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC---FKWYTSPWSECTKTCGV 871
           + RLV C       P       C    +P +  +C   PC    +W   PW+ C+ +CG 
Sbjct: 298 QSRLVFCTIDHEAYPDHM----CQRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGG 353

Query: 872 GVRMRDVKCY--QGTDIVRGCDPLV------KPVGRQACDLQPCPTEPPDDSCQDQPGTN 923
           G + R V C    G  I    +         KP   QAC+LQ C    P      +P   
Sbjct: 354 GSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAWSP------EPWGE 407

Query: 924 CALAIKVNL------C----GHWYYSKACCRSCRPP 949
           C+++  V +      C    G   ++ AC    RPP
Sbjct: 408 CSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPP 443



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 24/54 (44%), Positives = 29/54 (53%), Gaps = 6/54 (11%)

Query: 904  LQPCPTEPPDD---SCQDQPG-TNCALAIKVNLCGHWYYSKACCRSCR--PPHS 951
            + P PT  P D    C DQP   NC L ++  LCG+ YYS  CC SC    PH+
Sbjct: 1193 VSPAPTAQPRDPGRDCVDQPELANCDLILQAQLCGNEYYSSFCCASCSRFQPHA 1246



 Score = 37.0 bits (84), Expect = 0.088
 Identities = 29/90 (32%), Positives = 37/90 (41%), Gaps = 11/90 (12%)

Query: 839 LAKKPPEESTCFERPCFKWYT-SPWSECTKTCGVGVRMRDVKCY-QGTDIVRGCDPLVKP 896
           LA  P   +    R    W   S WS C++TCG GV  R+  CY Q  D   G    V P
Sbjct: 11  LAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRD---GGSSCVGP 67

Query: 897 V-GRQACDLQPCPTEPPDDSCQDQPGTNCA 925
               ++C  + CP     D  +D     CA
Sbjct: 68  ARSHRSCRTESCP-----DGARDFRAEQCA 92



 Score = 31.6 bits (70), Expect = 3.7
 Identities = 16/54 (29%), Positives = 23/54 (42%), Gaps = 4/54 (7%)

Query: 56  WTACSRSCGGGVTSQERHCLQQR----RKSVPGPGNRTCTGTSKRYQLCRVQEC 105
           W  CS SCGGG  S+  +C+       +++V         G     Q C +Q C
Sbjct: 344 WAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397


>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
           type) with thrombospondin type 1 motif, 15 preproprotein
           [Homo sapiens]
          Length = 950

 Score =  148 bits (374), Expect = 2e-35
 Identities = 104/307 (33%), Positives = 146/307 (47%), Gaps = 35/307 (11%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPD- 108
           W +W  +  CSR+CGGGV    R C        P  G + C G   +Y+ C ++ CP   
Sbjct: 519 WAKWDPYGPCSRTCGGGVQLARRQCTNP----TPANGGKYCEGVRVKYRSCNLEPCPSSA 574

Query: 109 -GRSFREEQCVSFNSHVYNGRTHQ------WKPLYPDDYVHISSKP-CDLHC-TTVDGQR 159
            G+SFREEQC +FN   YN  T++      W P Y      +S +  C L C     G  
Sbjct: 575 SGKSFREEQCEAFNG--YNHSTNRLTLAVAWVPKYSG----VSPRDKCKLICRANGTGYF 628

Query: 160 QLMVP-ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTG 218
            ++ P   DGT C   D   VCV GKC   GCDG L S    DKCG+C GD  SC  VTG
Sbjct: 629 YVLAPKVVDGTLCS-PDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTG 687

Query: 219 NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSA-----DVLALADEAGYYFFNGNYKVDS 273
            + K     GY+ V  IPAGA  I I +R         + LAL +  G Y  NG++ V +
Sbjct: 688 LFTK--PMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSA 745

Query: 274 -PKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKS-PSITFEYTLL 331
             ++  + G++++Y        T +E + A  P  + L V V +    + P + + + L 
Sbjct: 746 VERDLVVKGSLLRYSGT----GTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLP 801

Query: 332 QPPHESR 338
           + P E +
Sbjct: 802 KEPREDK 808



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 46/120 (38%), Positives = 61/120 (50%), Gaps = 8/120 (6%)

Query: 791 DKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCF 850
           D   PA W+A  W  C+ +CG G++KR V C     G    R+ P C  A +P E   C 
Sbjct: 836 DDRPPARWVAGSWGPCSASCGSGLQKRAVDC----RGSAGQRTVPACDAAHRPVETQACG 891

Query: 851 ERPCFKWYTSPWSECTKTCGVGVRMRDVKC--YQGTDIVRG-CDPLVKPVGRQACDLQPC 907
           E PC  W  S WS C+K+CG G + R +KC  + G  + R  C+   KP     C L+PC
Sbjct: 892 E-PCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950



 Score = 70.5 bits (171), Expect = 7e-12
 Identities = 42/123 (34%), Positives = 56/123 (45%), Gaps = 9/123 (7%)

Query: 676 ERKTCRNPACGPQWEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVGEKN 731
           E+   R PA   +W    W  C+A CG    +R+V  R          CD   RPV  + 
Sbjct: 833 EQPDDRPPA---RWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQA 889

Query: 732 CTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGD 791
           C G PC   W +S W PCS SCG+G   R + C    GR++   QC +  KP  +  C  
Sbjct: 890 C-GEPCPT-WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVL 947

Query: 792 KNC 794
           + C
Sbjct: 948 RPC 950



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 40/118 (33%), Positives = 55/118 (46%), Gaps = 15/118 (12%)

Query: 532 PNVSTSLLTSAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMC 591
           P+V  + + S  N+  +   RP AR           W   S  PCSA+C +G+      C
Sbjct: 818 PSVLHNSVLSLSNQVEQPDDRPPAR-----------WVAGSWGPCSASCGSGLQKRAVDC 866

Query: 592 VRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRC 649
               G     + CDA  RP  V     G  C P WE S+WS CS++CG G+Q R ++C
Sbjct: 867 RGSAGQRTVPA-CDAAHRP--VETQACGEPC-PTWELSAWSPCSKSCGRGFQRRSLKC 920



 Score = 37.0 bits (84), Expect = 0.088
 Identities = 20/66 (30%), Positives = 36/66 (54%), Gaps = 6/66 (9%)

Query: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG--CDPLVKPVGRQACDLQPCPTEPPD 913
           KW   P+  C++TCG GV++   +C   T    G  C+ +   V  ++C+L+PCP+    
Sbjct: 521 KW--DPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGV--RVKYRSCNLEPCPSSASG 576

Query: 914 DSCQDQ 919
            S +++
Sbjct: 577 KSFREE 582



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 26/85 (30%), Positives = 37/85 (43%), Gaps = 6/85 (7%)

Query: 541 SAGNRTHKA---RTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGV 597
           SAG RT  A     RP   +    P     W+LS+  PCS +C  G       CV + G 
Sbjct: 869 SAGQRTVPACDAAHRPVETQACGEPCPT--WELSAWSPCSKSCGRGFQRRSLKCVGHGGR 926

Query: 598 EVDDSYCDALTRPEPVHEFCAGREC 622
            +    C+   +P+ + +FC  R C
Sbjct: 927 LLARDQCNLHRKPQEL-DFCVLRPC 950


>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
           1 preproprotein [Homo sapiens]
          Length = 967

 Score =  140 bits (353), Expect = 6e-33
 Identities = 95/294 (32%), Positives = 141/294 (47%), Gaps = 30/294 (10%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPD- 108
           WG W  W  CSR+CGGGV    R C       VP  G + C G   RY+ C +++CP + 
Sbjct: 562 WGMWGPWGDCSRTCGGGVQYTMREC----DNPVPKNGGKYCEGKRVRYRSCNLEDCPDNN 617

Query: 109 GRSFREEQCVSFN----SHVYNGRTHQWKPLYPDDYVHISSKP-CDLHCTTVD-GQRQLM 162
           G++FREEQC + N    +   +G   +W P     Y  +S K  C L C     G   ++
Sbjct: 618 GKTFREEQCEAHNEFSKASFGSGPAVEWIP----KYAGVSPKDRCKLICQAKGIGYFFVL 673

Query: 163 VP-ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYR 221
            P   DGT C   D   VCV G+C   GCD ++ S    DKCG+C G+GS+C  ++G+  
Sbjct: 674 QPKVVDGTPCS-PDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVT 732

Query: 222 KGNAHLGYSLVTHIPAGARDIQIVER-----KKSADVLALADEAGYYFFNGNYKVDS-PK 275
             +A  GY  +  IP GA +I++ +R     + +   LA+    G Y  NG+Y + +  +
Sbjct: 733 --SAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQ 790

Query: 276 NFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWN-QNGKSPSITFEY 328
           +    G V++Y          +E I +  P  + L + V    N   P I + Y
Sbjct: 791 DIMYKGVVLRYSGS----SAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTY 840



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 41/108 (37%), Positives = 53/108 (49%), Gaps = 6/108 (5%)

Query: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCP 795
           P    W + +WG CS SC  G   R V C+  +G+  P S+C  E KP +  PC D  CP
Sbjct: 853 PTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQ--PASECAKEVKPASTRPCADHPCP 910

Query: 796 AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKP 843
             W   +W  C+ TCG+G KKR + C+    G     S   C   KKP
Sbjct: 911 -QWQLGEWSSCSKTCGKGYKKRSLKCLSHDGG---VLSHESCDPLKKP 954



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 38/102 (37%), Positives = 54/102 (52%), Gaps = 8/102 (7%)

Query: 798 WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKW 857
           W+ ++W  C+ +C  G ++RLV C ++ NG+P +    EC    KP     C + PC +W
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDI-NGQPAS----ECAKEVKPASTRPCADHPCPQW 912

Query: 858 YTSPWSECTKTCGVGVRMRDVKCYQ---GTDIVRGCDPLVKP 896
               WS C+KTCG G + R +KC     G      CDPL KP
Sbjct: 913 QLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 32/99 (32%), Positives = 44/99 (44%), Gaps = 6/99 (6%)

Query: 689 WEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVS 744
           W + EW EC+  C      R V  RDI   +    C    +P   + C   PC  QW + 
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDIN-GQPASECAKEVKPASTRPCADHPCP-QWQLG 915

Query: 745 DWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKP 783
           +W  CS +CG+G   R + C + DG V+    C    KP
Sbjct: 916 EWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 34/107 (31%), Positives = 51/107 (47%), Gaps = 16/107 (14%)

Query: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
           W    W ECS++C  G+Q R+V C  +              E A+ V+P   + C +  C
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDING--------QPASECAKEVKPASTRPCADHPC 909

Query: 686 GPQWEMSEWSECTAKCGERSVVTRDIRC-SED-----EKLCDPNTRP 726
            PQW++ EWS C+  CG +    R ++C S D      + CDP  +P
Sbjct: 910 -PQWQLGEWSSCSKTCG-KGYKKRSLKCLSHDGGVLSHESCDPLKKP 954



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 46/168 (27%), Positives = 67/168 (39%), Gaps = 31/168 (18%)

Query: 506 GPYLLNGSYL--ELSSD--------RVANSS-------SEAPFPNVSTSLLTSAGNRTH- 547
           G Y+LNG Y    L  D        R + SS       S +P     T  + + GN    
Sbjct: 775 GTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRP 834

Query: 548 --KARTRPKARKQGVSPADMYR-WKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYC 604
             K     K +K+  +    +  W +     CS +C  G       C   +G    +   
Sbjct: 835 KIKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAK 894

Query: 605 D---ALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRC 649
           +   A TRP      CA   C P+W+   WS CS+TCG+GY+ R ++C
Sbjct: 895 EVKPASTRP------CADHPC-PQWQLGEWSSCSKTCGKGYKKRSLKC 935



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 18/56 (32%), Positives = 26/56 (46%)

Query: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC 622
           +W+L     CS TC  G       C+ +DG  +    CD L +P+   +FC   EC
Sbjct: 911 QWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966



 Score = 38.5 bits (88), Expect = 0.030
 Identities = 18/53 (33%), Positives = 24/53 (45%), Gaps = 1/53 (1%)

Query: 857 WYTSPWSECTKTCGVGVRMRDVKCYQ-GTDIVRGCDPLVKPVGRQACDLQPCP 908
           W    W EC+K+C +G + R V+C          C   VKP   + C   PCP
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCP 910



 Score = 33.5 bits (75), Expect = 0.97
 Identities = 16/48 (33%), Positives = 25/48 (52%)

Query: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 908
           PW +C++TCG GV+    +C        G     K V  ++C+L+ CP
Sbjct: 567 PWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCP 614



 Score = 30.8 bits (68), Expect = 6.3
 Identities = 10/19 (52%), Positives = 13/19 (68%)

Query: 631 WSECSRTCGEGYQFRVVRC 649
           W +CSRTCG G Q+ +  C
Sbjct: 568 WGDCSRTCGGGVQYTMREC 586


>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
           motif, 17 preproprotein [Homo sapiens]
          Length = 1095

 Score =  138 bits (348), Expect = 2e-32
 Identities = 95/286 (33%), Positives = 136/286 (47%), Gaps = 54/286 (18%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           W  W  W+ CSR+CG G   ++R C        PGPG   C G S  + +C    CP   
Sbjct: 546 WSPWGAWSMCSRTCGTGARFRQRKC----DNPPPGPGGTHCPGASVEHAVCENLPCPKGL 601

Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPAR--D 167
            SFR++QC       ++  + + K L     V +  KPC+L+C+ +  +  L+V  R  D
Sbjct: 602 PSFRDQQC-----QAHDRLSPKKKGLLTA--VVVDDKPCELYCSPLGKESPLLVADRVLD 654

Query: 168 GTSCKL--TDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNA 225
           GT C    TDL   CV GKC+ IGCDG++ S    D+CG+C GDG +C  V G++     
Sbjct: 655 GTPCGPYETDL---CVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDF----- 706

Query: 226 HLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVK 285
                                    A   AL D +G    N ++K++ P  F IAGT V+
Sbjct: 707 -----------------------SHARGTALKD-SGKGSINSDWKIELPGEFQIAGTTVR 742

Query: 286 YRRPMDVYETGI-EYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTL 330
           Y R       G+ E I A+GPT   L++MV   + +   I +EYT+
Sbjct: 743 YVR------RGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTV 782



 Score =  137 bits (345), Expect = 5e-32
 Identities = 85/256 (33%), Positives = 112/256 (43%), Gaps = 17/256 (6%)

Query: 544  NRTHKARTRPKARKQGVSPAD-MYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE---V 599
            NRT + ++ P+       P D ++ W  S  E CS  C  G       C R        V
Sbjct: 785  NRTAENQSEPE------KPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLV 838

Query: 600  DDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDS 659
            +DS C   +RPEP    C    CQ RW    WS CS TC +G+Q R V C   L  G   
Sbjct: 839  NDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHV 898

Query: 660  SVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL 719
            +     C      RP   ++C    C   WE SEWS+C+A CG + V  R + C+  +  
Sbjct: 899  ATRPLYCPGP---RPAAVQSCEGQDCLSIWEASEWSQCSASCG-KGVWKRTVACTNSQGK 954

Query: 720  CDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQ 778
            CD +TRP  E+ C       +W   DW  CS +CG+G   R V C     GR    S+C 
Sbjct: 955  CDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR--HGSECP 1012

Query: 779  METKPLAIHPCGDKNC 794
              +KP     C  + C
Sbjct: 1013 ALSKPAPYRQCYQEVC 1028



 Score =  131 bits (330), Expect = 3e-30
 Identities = 75/238 (31%), Positives = 103/238 (43%), Gaps = 22/238 (9%)

Query: 626  WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
            W  S W  CS  CG G +  +V C ++++        SD C  A    P+ R+ C    C
Sbjct: 804  WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSD-CPQASRPEPQVRR-CNLHPC 861

Query: 686  GPQWEMSEWSECTAKCGERSVVTRDIRCSED---------EKLCDPNTRPVGEKNCTGPP 736
              +W    WS C+A C E+    R++ C              L  P  RP   ++C G  
Sbjct: 862  QSRWVAGPWSPCSATC-EKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQD 920

Query: 737  CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPA 796
            C   W  S+W  CS SCG+G   R V C  S G+      C   T+P A   C D +   
Sbjct: 921  CLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK------CDASTRPRAEEACEDYSGCY 974

Query: 797  HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC 854
             W   DW  C++TCG+G++ R+V CM    G    R G EC    KP     C++  C
Sbjct: 975  EWKTGDWSTCSSTCGKGLQSRVVQCMHKVTG----RHGSECPALSKPAPYRQCYQEVC 1028



 Score =  126 bits (317), Expect = 8e-29
 Identities = 82/287 (28%), Positives = 127/287 (44%), Gaps = 37/287 (12%)

Query: 689  WEMSEWSECTAKCG---ERSVV--TRDIRCSE---DEKLCDPNTRPVGE-KNCTGPPCDR 739
            W  S W  C+ +CG    R++V  TR +  +    ++  C   +RP  + + C   PC  
Sbjct: 804  WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQS 863

Query: 740  QWTVSDWGPCSGSCGQGRTIRHVYC--KTSDGRVVPESQCQME-TKPLAIHPCGDKNCPA 796
            +W    W PCS +C +G   R V C  +  +G  V          +P A+  C  ++C +
Sbjct: 864  RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLS 923

Query: 797  HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP-CF 855
             W A +W +C+ +CG+GV KR V C         T S  +C  + +P  E  C +   C+
Sbjct: 924  IWEASEWSQCSASCGKGVWKRTVAC---------TNSQGKCDASTRPRAEEACEDYSGCY 974

Query: 856  KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG--CDPLVKPVGRQACDLQPCP----- 908
            +W T  WS C+ TCG G++ R V+C        G  C  L KP   + C  + C      
Sbjct: 975  EWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINA 1034

Query: 909  ---TEP-----PDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCR 947
               T P          +DQ    C +  + NLC    + + CC++CR
Sbjct: 1035 NTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCR 1081



 Score = 38.1 bits (87), Expect = 0.039
 Identities = 21/59 (35%), Positives = 24/59 (40%), Gaps = 3/59 (5%)

Query: 862 WSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPP---DDSCQ 917
           WS C++TCG G R R  KC        G       V    C+  PCP   P   D  CQ
Sbjct: 552 WSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQ 610



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 88/387 (22%), Positives = 138/387 (35%), Gaps = 89/387 (22%)

Query: 595 DGVEVD-DSYCDA--LTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWK 651
           DG E   D +C A       P+ E   G +  P W   +WS CSRTCG G +FR  +C  
Sbjct: 517 DGTECGADKWCRAGECVSKTPIPEHVDG-DWSP-W--GAWSMCSRTCGTGARFRQRKC-D 571

Query: 652 MLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTA----KCGERSVV 707
              PG   +     C  A      E   C N  C          +C A       ++ ++
Sbjct: 572 NPPPGPGGT----HCPGASV----EHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLL 623

Query: 708 TRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPC----SGSCGQGRTIRHVY 763
           T  +    D+K C+    P+G+++    P      V D  PC    +  C  G+  + + 
Sbjct: 624 TAVV---VDDKPCELYCSPLGKES----PLLVADRVLDGTPCGPYETDLCVHGK-CQKIG 675

Query: 764 CKTSDGRVVPESQCQM----------------ETKPLAIHPCGDKNCPAHW---LAQDWE 804
           C    G    E +C +                  +  A+   G  +  + W   L  +++
Sbjct: 676 CDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKGSINSDWKIELPGEFQ 735

Query: 805 RCNTTCGRGVKKRLVLCMELANGKPQTR----------SGPECGL-------AKKPPEES 847
              TT  R V++ L    E  + K  T+             + G+         +  E  
Sbjct: 736 IAGTTV-RYVRRGL---WEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQ 791

Query: 848 TCFERP---CFKWYTSPWSECTKTCGVGVRMRDVKC----YQGTDIVR--GCDPLVKPVG 898
           +  E+P    F W  S W  C+  CG G R   V C     + T +V    C    +P  
Sbjct: 792 SEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEP 851

Query: 899 R-QACDLQPC-------PTEPPDDSCQ 917
           + + C+L PC       P  P   +C+
Sbjct: 852 QVRRCNLHPCQSRWVAGPWSPCSATCE 878



 Score = 33.5 bits (75), Expect = 0.97
 Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 6/84 (7%)

Query: 24   TVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVP 83
            T S G  D S    + E   D +  +  +   W+ CS +CG G+ S+   C+ +    V 
Sbjct: 949  TNSQGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHK----VT 1004

Query: 84   GPGNRTCTGTSK--RYQLCRVQEC 105
            G     C   SK   Y+ C  + C
Sbjct: 1005 GRHGSECPALSKPAPYRQCYQEVC 1028



 Score = 30.8 bits (68), Expect = 6.3
 Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 2/39 (5%)

Query: 42  GTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRK 80
           G D  + W  E ++W+ CS SCG GV  +   C   + K
Sbjct: 918 GQDCLSIW--EASEWSQCSASCGKGVWKRTVACTNSQGK 954


>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
          Length = 1691

 Score =  138 bits (347), Expect = 3e-32
 Identities = 82/250 (32%), Positives = 117/250 (46%), Gaps = 38/250 (15%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           W  W  W+ CSR+CGGG +   R CL            R C G + RY+ C   +CPPD 
Sbjct: 78  WDAWGDWSDCSRTCGGGASYSLRRCLT----------GRNCEGQNIRYKTCSNHDCPPDA 127

Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQR---QLMVPAR 166
             FR +QC ++N   Y G  ++W P Y D      + PC L C    GQ    +L     
Sbjct: 128 EDFRAQQCSAYNDVQYQGHYYEWLPRYND-----PAAPCALKC-HAQGQNLVVELAPKVL 181

Query: 167 DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSC--------THVTG 218
           DGT C  TD   +C+SG C+ +GCD  L S    D CG+C GDGS+C        +HV+ 
Sbjct: 182 DGTRCN-TDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSP 240

Query: 219 NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFN 278
             R+ N       V  +P G+R ++I  +  +   +      G     G +  +SP  F 
Sbjct: 241 EKREEN-------VIAVPLGSRSVRITVKGPAHLFIESKTLQG---SKGEHSFNSPGVFL 290

Query: 279 IAGTVVKYRR 288
           +  T V+++R
Sbjct: 291 VENTTVEFQR 300



 Score =  138 bits (347), Expect = 3e-32
 Identities = 100/374 (26%), Positives = 148/374 (39%), Gaps = 62/374 (16%)

Query: 564 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEV------------------------ 599
           D  +W       C+ TC  G+     +C+ + G  V                        
Sbjct: 478 DCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKP 537

Query: 600 -DDSYCDA----LTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLS 654
            + S  +A    L + + + E     E +P +    WS CS TCG G Q R V+C  +L+
Sbjct: 538 KEKSPVEAKLPWLKQAQELEETRIATE-EPTFIPEPWSACSTTCGPGVQVREVKCRVLLT 596

Query: 655 -PGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQ-------------------WEMSEW 694
               ++ +  + CE  +   P ER  C   AC                      WE + +
Sbjct: 597 FTQTETELPEEECEGPKL--PTERP-CLLEACDESPASRELDIPLPEDSETTYDWEYAGF 653

Query: 695 SECTAKC----GERSVVTRDIRCSE--DEKLCDPNTRPVG-EKNCTGPPCDRQWTVSDWG 747
           + CTA C     E   V   I+  +  ++ LCD   RP    + C   PC  +W V  WG
Sbjct: 654 TPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWG 713

Query: 748 PCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCN 807
           PCS +CG G   R VYC        P  +C+ E KP A+  C   +CP  W  ++W++C+
Sbjct: 714 PCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQACNQFDCPPGWHIEEWQQCS 772

Query: 808 TTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWY-TSPWSECT 866
            TCG G + R V C +L           E     K     +C    C        WS+C+
Sbjct: 773 RTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCS 832

Query: 867 KTCGVGVRMRDVKC 880
            +CGVG++ R   C
Sbjct: 833 VSCGVGIQRRKQVC 846



 Score =  130 bits (326), Expect = 8e-30
 Identities = 83/242 (34%), Positives = 109/242 (45%), Gaps = 11/242 (4%)

Query: 559  GVSPADMYRWKLSSHEPCSATCT-TGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFC 617
            G  P     W+  +   CSATC   G       CV  +G EV ++ CD L +P    E C
Sbjct: 1419 GEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPC 1478

Query: 618  AGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEER 677
              R+C  RW TS WS+CS +CGEGY  R V C +  + G    V    C  A   RP  R
Sbjct: 1479 NIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRAC--APKDRPLGR 1536

Query: 678  KTCRNPACGPQWEMSEWSECTAKCGERSV--VTRDIRC--SEDEKLCDPNTRPVGEKNCT 733
            K C    C  QWE    + C  +C  R+V    R   C  +  +  CD   RP   +NCT
Sbjct: 1537 KPCFGHPC-VQWEPG--NRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCT 1593

Query: 734  GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQMETKPLAIHPCGDK 792
               CD  W    W PC+ +CG+G   R V C  T   + V +  C  + KP++   C   
Sbjct: 1594 SGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP 1653

Query: 793  NC 794
            +C
Sbjct: 1654 SC 1655



 Score =  126 bits (316), Expect = 1e-28
 Identities = 114/453 (25%), Positives = 171/453 (37%), Gaps = 106/453 (23%)

Query: 550 RTRPKARKQGVSPADMYR-----WKLSSHEPCSATCTTGVMSAYAMCV--RYDGVEVDDS 602
           +TR  A K  V     Y+     W+ +   PC+ TC  G     A CV  R   V V D 
Sbjct: 320 KTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRV-VPDH 378

Query: 603 YCDAL---TRPEPVHEFCAGRECQ-----------------PRWETSSWSECSRTCGEGY 642
           YC       +P+P  + C+   C                  PRWE + W+ CS +CG G 
Sbjct: 379 YCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGI 438

Query: 643 QFRVVRCWKMLSPGFDSSVYSDLCEAAE-----AVRPEERKTCRNPACGPQWEMSEWSEC 697
           Q R   C        + S++ ++ +  E     A +P+  +TC    C P+W   EWS+C
Sbjct: 439 QRRSFVC-------VEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDC-PKWIAMEWSQC 490

Query: 698 TAKCGERSVVTRDIRC----SEDEKLCDPNTRPVGEKNCTGP-PC--------------- 737
           T  CG R +  R + C     E    C+P  +   ++ C  P PC               
Sbjct: 491 TVTCG-RGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPW 549

Query: 738 ---------------DRQWTVSDWGPCSGSCGQGRTIRHVYCK-----TSDGRVVPESQC 777
                          +  +    W  CS +CG G  +R V C+     T     +PE +C
Sbjct: 550 LKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEEC 609

Query: 778 Q----METKPLAIHPCG--------------DKNCPAHWLAQDWERCNTTCGRGVKKRLV 819
           +       +P  +  C               D      W    +  C  TC  G ++ + 
Sbjct: 610 EGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIA 669

Query: 820 LCMELANGKPQTRSGPECGLAKKPPEES-TCFERPC-FKWYTSPWSECTKTCGVGVRMRD 877
           +C+ +     QT +   C +  +PP  S  C   PC  +W+   W  C+ TCGVG++ RD
Sbjct: 670 VCLHIQT--QQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRD 727

Query: 878 VKCYQGTDIVRGCDPL--VKPVGRQACDLQPCP 908
           V C    +     +     KP   QAC+   CP
Sbjct: 728 VYCLHPGETPAPPEECRDEKPHALQACNQFDCP 760



 Score =  123 bits (308), Expect = 9e-28
 Identities = 72/230 (31%), Positives = 101/230 (43%), Gaps = 20/230 (8%)

Query: 566 YRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALTRPEPVHEFCAGRECQP 624
           Y W+ +   PC+ATC  G   A A+C+     + V+DS CD + RP  + + C    C P
Sbjct: 646 YDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPP 705

Query: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
           RW   SW  CS TCG G Q R V C   L PG ++    + C      +P   + C    
Sbjct: 706 RWHVGSWGPCSATCGVGIQTRDVYC---LHPG-ETPAPPEECRDE---KPHALQACNQFD 758

Query: 685 CGPQWEMSEWSECTAKCGE---------RSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGP 735
           C P W + EW +C+  CG          R ++T     +  ++LC    +    K+C   
Sbjct: 759 CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQ-GPKASSHKSCART 817

Query: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCK--TSDGRVVPESQCQMETKP 783
            C     V DW  CS SCG G   R   C+   + GR +P S+      P
Sbjct: 818 DCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLP 867



 Score =  116 bits (291), Expect = 9e-26
 Identities = 92/375 (24%), Positives = 149/375 (39%), Gaps = 66/375 (17%)

Query: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRY----DGVEVDDSYCDALTRPEPVHEFCAGREC 622
           RW+ +    CS +C  G+     +CV      + ++V++  C    +P+ V + C   +C
Sbjct: 421 RWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPK-VMQTCNLFDC 479

Query: 623 QPRWETSSWSECSRTCGEGYQFRVVRCWKM-------LSPGFDSSVYSDLCEAAEAVRPE 675
            P+W    WS+C+ TCG G ++RVV C           +P     +  +        +P+
Sbjct: 480 -PKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPK 538

Query: 676 ERKT--CRNPACGPQWEMSE--------------WSECTAKCGERSVVTRDIRCSE---- 715
           E+     + P      E+ E              WS C+  CG   V  R+++C      
Sbjct: 539 EKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGP-GVQVREVKCRVLLTF 597

Query: 716 -------DEKLCD----PNTRPVGEKNCTGPPCDRQ--------------WTVSDWGPCS 750
                   E+ C+    P  RP   + C   P  R+              W  + + PC+
Sbjct: 598 TQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCT 657

Query: 751 GSCGQGRTIRHVYC-KTSDGRVVPESQCQMETKPLAI-HPCGDKNCPAHWLAQDWERCNT 808
            +C  G       C      + V +S C M  +P A+   C  + CP  W    W  C+ 
Sbjct: 658 ATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSA 717

Query: 809 TCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTK 867
           TCG G++ R V C+       +T + PE    +KP     C +  C   W+   W +C++
Sbjct: 718 TCGVGIQTRDVYCLHPG----ETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSR 773

Query: 868 TCGVGVRMRDVKCYQ 882
           TCG G + R V C Q
Sbjct: 774 TCGGGTQNRRVTCRQ 788



 Score =  107 bits (268), Expect = 4e-23
 Identities = 78/287 (27%), Positives = 103/287 (35%), Gaps = 79/287 (27%)

Query: 726  PVGEKNCTGPPCDRQWTVSDWGPCSGSCGQ-GRTIRHVYCKTSDGRVVPESQCQMETKPL 784
            P GE     PP +  W   +W  CS +CG  G  I+   C  ++G+ V E+ C    KPL
Sbjct: 1417 PTGEP----PPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPL 1472

Query: 785  A-IHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQTRSGPECGLAKK 842
            A   PC  ++CPA W    W +C+ +CG G   R V C    ANG  Q  S   C    +
Sbjct: 1473 AGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDR 1532

Query: 843  PPEESTCF-------------------------------------------ERPCFK--- 856
            P     CF                                           +RP  +   
Sbjct: 1533 PLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNC 1592

Query: 857  --------WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVK--------PVGRQ 900
                    W+T PW  CT  CG G + R V C       R C P+ K        P+  +
Sbjct: 1593 TSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIH----TRSCKPVAKRHCVQKKKPISWR 1648

Query: 901  ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCR 947
             C    C     D  C D     C     +NLC    Y + CC+SC+
Sbjct: 1649 HCLGPSC-----DRDCTDTTHY-CMFVKHLNLCSLDRYKQRCCQSCQ 1689



 Score =  106 bits (264), Expect = 1e-22
 Identities = 73/280 (26%), Positives = 112/280 (40%), Gaps = 35/280 (12%)

Query: 576 CSATCTTGVMSAYAMC-----VRYDGVEVDDSYCDALTRP-------EPVHEFCAGRECQ 623
           CS TC  GV      C           E+ +  C+    P       E   E  A RE  
Sbjct: 576 CSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRELD 635

Query: 624 ---PR-------WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 673
              P        WE + ++ C+ TC  G+Q  +  C  + +     +V   LC+      
Sbjct: 636 IPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQT---QQTVNDSLCDMVHRP- 691

Query: 674 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDP-----NTRPVG 728
           P   + C    C P+W +  W  C+A CG   + TRD+ C    +   P     + +P  
Sbjct: 692 PAMSQACNTEPCPPRWHVGSWGPCSATCGV-GIQTRDVYCLHPGETPAPPEECRDEKPHA 750

Query: 729 EKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT--SDGRVVPESQCQMETKPLAI 786
            + C    C   W + +W  CS +CG G   R V C+   +DG  +  S    +    + 
Sbjct: 751 LQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASS 810

Query: 787 HP-CGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELA 825
           H  C   +CP H    DW +C+ +CG G+++R  +C  LA
Sbjct: 811 HKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLA 850



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 61/205 (29%), Positives = 93/205 (45%), Gaps = 29/205 (14%)

Query: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQ-----METKPLAIHPC 789
           P   QW  +D+ PC+ +CG G  +    C      RVVP+  C      ++ KP  +  C
Sbjct: 338 PISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKP-KLKEC 396

Query: 790 GDKNCPA-----------------HWLAQDWERCNTTCGRGVKKRLVLCMELA-NGKPQT 831
               CP+                  W    W  C+ +CG G+++R  +C+E + +G+   
Sbjct: 397 SMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQ 456

Query: 832 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKC--YQGTDIVRG 889
               +C  A KP    TC    C KW    WS+CT TCG G+R R V C  ++G + V G
Sbjct: 457 VEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRG-EHVGG 515

Query: 890 CDPLVKPVGRQACDLQPCPTEPPDD 914
           C+P +K   ++ C + P P   P +
Sbjct: 516 CNPQLKLHIKEECVI-PIPCYKPKE 539



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 52/187 (27%), Positives = 72/187 (38%), Gaps = 23/187 (12%)

Query: 567  RWKLSSHEPCSATCTTGVMSAYAMCVRYDG----VEVDDSYCDALTRPEPVHEFCAGREC 622
            RW  S    CS +C  G  S    C R         V    C    RP    + C G  C
Sbjct: 1486 RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLG-RKPCFGHPC 1544

Query: 623  QPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRN 682
              +WE  +   C   C      R VR  +  +    +S  S+ C+  +  RP  R+ C +
Sbjct: 1545 V-QWEPGN--RCPGRC----MGRAVRMQQRHTACQHNSSDSN-CD--DRKRPTLRRNCTS 1594

Query: 683  PACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-------EKLCDPNTRPVGEKNCTGP 735
             AC   W    W  CTA CG R   +R + C          ++ C    +P+  ++C GP
Sbjct: 1595 GACDVCWHTGPWKPCTAACG-RGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP 1653

Query: 736  PCDRQWT 742
             CDR  T
Sbjct: 1654 SCDRDCT 1660



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 23/75 (30%), Positives = 30/75 (40%), Gaps = 16/75 (21%)

Query: 626 WET-SSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
           W+    WS+CSRTCG G  + + RC           +    CE          KTC N  
Sbjct: 78  WDAWGDWSDCSRTCGGGASYSLRRC-----------LTGRNCEGQNI----RYKTCSNHD 122

Query: 685 CGPQWEMSEWSECTA 699
           C P  E     +C+A
Sbjct: 123 CPPDAEDFRAQQCSA 137



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 21/76 (27%), Positives = 32/76 (42%), Gaps = 11/76 (14%)

Query: 862 WSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPG 921
           WS+C++TCG G      +C  G    R C+   + +  + C    CP +  D   Q    
Sbjct: 84  WSDCSRTCGGGASYSLRRCLTG----RNCEG--QNIRYKTCSNHDCPPDAEDFRAQ---- 133

Query: 922 TNCALAIKVNLCGHWY 937
             C+    V   GH+Y
Sbjct: 134 -QCSAYNDVQYQGHYY 148



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 17/62 (27%), Positives = 25/62 (40%), Gaps = 2/62 (3%)

Query: 56  WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREE 115
           W  CS +CG G+ +++ +CL       P P            Q C   +CPP       +
Sbjct: 712 WGPCSATCGVGIQTRDVYCLHP--GETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQ 769

Query: 116 QC 117
           QC
Sbjct: 770 QC 771



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 17/55 (30%), Positives = 26/55 (47%), Gaps = 2/55 (3%)

Query: 55  KWTACSRSCGGGVTSQERHCLQQRRK-SVPGPGNRTCTG-TSKRYQLCRVQECPP 107
           +W  CSR+CGGG  ++   C Q     S     +  C G  +  ++ C   +CPP
Sbjct: 767 EWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPP 821



 Score = 32.7 bits (73), Expect = 1.7
 Identities = 12/26 (46%), Positives = 17/26 (65%)

Query: 52  EWTKWTACSRSCGGGVTSQERHCLQQ 77
           E   WTACS SCGGG+  +   C+++
Sbjct: 423 EHNPWTACSVSCGGGIQRRSFVCVEE 448



 Score = 31.6 bits (70), Expect = 3.7
 Identities = 23/95 (24%), Positives = 34/95 (35%), Gaps = 16/95 (16%)

Query: 791 DKNCPAHWLAQ-DWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC 849
           D++   +W A  DW  C+ TCG G    L  C+   N + Q      C     PP+    
Sbjct: 71  DEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDF 130

Query: 850 FERPC------------FKW---YTSPWSECTKTC 869
             + C            ++W   Y  P + C   C
Sbjct: 131 RAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKC 165


>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
           motif, 4 preproprotein [Homo sapiens]
          Length = 837

 Score =  135 bits (339), Expect = 2e-31
 Identities = 102/309 (33%), Positives = 137/309 (44%), Gaps = 36/309 (11%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           WG W  W  CSR+CGGGV    R C     + VP  G + C G   R++ C  ++CP   
Sbjct: 523 WGPWGPWGDCSRTCGGGVQFSSRDCT----RPVPRNGGKYCEGRRTRFRSCNTEDCPTGS 578

Query: 110 R-SFREEQCVSFNSHVYNGRTH----QWKPLY----PDDYVHISSKPCDLHCTTVD-GQR 159
             +FREEQC ++N      ++      W P Y    P D        C L C     G  
Sbjct: 579 ALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQ-------CKLTCQAQALGYY 631

Query: 160 QLMVP-ARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTG 218
            ++ P   DGT C   D   VCV G+C   GCD ++ S    DKC +C GDGS C+  +G
Sbjct: 632 YVLEPRVVDGTPCS-PDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSG 690

Query: 219 NYRKGNAHLGYSLVTHIPAGARDIQIVERKKSAD---VLALADEAGYYFFNGNYK-VDSP 274
           ++RK     GY+ V  IPAGA  I + ++         LAL    G Y  NG Y  + SP
Sbjct: 691 SFRK--FRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSP 748

Query: 275 KNFNIAGTV-VKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP 333
            +  + G V ++Y       ET    +   GP  Q L + V    G        Y+   P
Sbjct: 749 TDVVLPGAVSLRYSGATAASET----LSGHGPLAQPLTLQVL-VAGNPQDTRLRYSFFVP 803

Query: 334 -PHESRPQP 341
            P  S P+P
Sbjct: 804 RPTPSTPRP 812



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 23/89 (25%), Positives = 32/89 (35%), Gaps = 21/89 (23%)

Query: 575 PCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSS---- 630
           PC+A   +G ++ +AMC        D + C          + C G  C    +       
Sbjct: 466 PCAALWCSGHLNGHAMCQTKHSPWADGTPCGPA-------QACMGGRCLHMDQLQDFNIP 518

Query: 631 ----------WSECSRTCGEGYQFRVVRC 649
                     W +CSRTCG G QF    C
Sbjct: 519 QAGGWGPWGPWGDCSRTCGGGVQFSSRDC 547



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 14/49 (28%), Positives = 24/49 (48%)

Query: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPT 909
           PW +C++TCG GV+     C +      G     +    ++C+ + CPT
Sbjct: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPT 576


>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
          Length = 525

 Score =  132 bits (332), Expect = 2e-30
 Identities = 88/287 (30%), Positives = 131/287 (45%), Gaps = 29/287 (10%)

Query: 50  WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
           W  W  W+ CSR+CGGG +   R CL           +++C G + RY+ C   +CPP+ 
Sbjct: 36  WDAWGPWSECSRTCGGGASYSLRRCLS----------SKSCEGRNIRYRTCSNVDCPPEA 85

Query: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQR--QLMVPARD 167
             FR +QC + N   ++G+ ++W P+  D        PC L C         +L     D
Sbjct: 86  GDFRAQQCSAHNDVKHHGQFYEWLPVSNDP-----DNPCSLKCQAKGTTLVVELAPKVLD 140

Query: 168 GTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG-NAH 226
           GT C  T+   +C+SG C+ +GCD  L ST   D CG+C GDGS+C  V G Y+   +A 
Sbjct: 141 GTRC-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSAT 199

Query: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKY 286
                V  IP G+R I++V   K  D L L  +       G   + S   F +  + V +
Sbjct: 200 KSDDTVVAIPYGSRHIRLV--LKGPDHLYLETKT-LQGTKGENSLSSTGTFLVDNSSVDF 256

Query: 287 RRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP 333
           ++  D      E +   GP      V +  +N  S   T ++   QP
Sbjct: 257 QKFPDK-----EILRMAGPLTADFIVKI--RNSGSADSTVQFIFYQP 296



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 60/204 (29%), Positives = 83/204 (40%), Gaps = 27/204 (13%)

Query: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQ-----METKPLAIHPC 789
           P   +W  +D+ PCS +CG G  +    C      RVV +  C      ++ KP  +  C
Sbjct: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKP-KLQEC 354

Query: 790 GDKNCPA-----------------HWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQT 831
               CPA                  W A  W  C+++CG G++ R V C+E    G   +
Sbjct: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTS 414

Query: 832 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDI-VRGC 890
               +C    K P    C    C KW    WS CT TCG G+R R V C     +   GC
Sbjct: 415 VEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474

Query: 891 DPLVKPVGRQACDLQPCPTEPPDD 914
            P  KP  ++ C + P P   P +
Sbjct: 475 SPKTKPHIKEEC-IVPTPCYKPKE 497



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 67/237 (28%), Positives = 93/237 (39%), Gaps = 47/237 (19%)

Query: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
           RW  + +  CS TCG GYQ     C+ + S    +  Y       E ++P+         
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYP--ENIKPK--------- 348

Query: 685 CGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVS 744
             P+ +      C A  G + ++  D        L  P  R               W  +
Sbjct: 349 --PKLQECNLDPCPASDGYKQIMPYD--------LYHPLPR---------------WEAT 383

Query: 745 DWGPCSGSCGQGRTIRHVYCKTSD--GRV--VPESQCQMETKPLAIHPCGDKNCPAHWLA 800
            W  CS SCG G   R V C   D  G V  V E +C    K     PC   +CP  WLA
Sbjct: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLA 442

Query: 801 QDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCF-ERPCFK 856
           Q+W  C  TCG+G++ R+VLC++    +     G  C    KP  +  C    PC+K
Sbjct: 443 QEWSPCTVTCGQGLRYRVVLCID---HRGMHTGG--CSPKTKPHIKEECIVPTPCYK 494



 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 60/200 (30%), Positives = 85/200 (42%), Gaps = 32/200 (16%)

Query: 565 MYRWKLSSHEPCSATCTTGVMSAYAMC--VRYDGVEVDDSYCDALT---RPEPVHEFCAG 619
           ++RW+ +   PCSATC  G     A C  +R + V V D YC       +P+P  + C  
Sbjct: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRV-VADQYCHYYPENIKPKPKLQECNL 356

Query: 620 RECQ-----------------PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
             C                  PRWE + W+ CS +CG G Q R V C +    G  +SV 
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416

Query: 663 SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL--- 719
              C      +    + C    C P+W   EWS CT  CG+  +  R + C +   +   
Sbjct: 417 EWKC--MYTPKMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQ-GLRYRVVLCIDHRGMHTG 472

Query: 720 -CDPNTRPVGEKNCTGP-PC 737
            C P T+P  ++ C  P PC
Sbjct: 473 GCSPKTKPHIKEECIVPTPC 492



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 22/58 (37%), Positives = 30/58 (51%), Gaps = 3/58 (5%)

Query: 52  EWTKWTACSRSCGGGVTSQERHCLQQR-RKSVPGPGNRTCTGTSKR--YQLCRVQECP 106
           E T WTACS SCGGG+ S+   C+++  +  V       C  T K    Q C + +CP
Sbjct: 381 EATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438



 Score = 37.4 bits (85), Expect = 0.067
 Identities = 23/69 (33%), Positives = 30/69 (43%), Gaps = 15/69 (21%)

Query: 631 WSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWE 690
           WSECSRTCG G  + + RC           + S  CE     R    +TC N  C P+  
Sbjct: 42  WSECSRTCGGGASYSLRRC-----------LSSKSCEG----RNIRYRTCSNVDCPPEAG 86

Query: 691 MSEWSECTA 699
                +C+A
Sbjct: 87  DFRAQQCSA 95



 Score = 32.3 bits (72), Expect = 2.2
 Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 6/57 (10%)

Query: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQ 917
           PWSEC++TCG G      +C       + C+   + +  + C    CP E  D   Q
Sbjct: 41  PWSECSRTCGGGASYSLRRCLSS----KSCEG--RNIRYRTCSNVDCPPEAGDFRAQ 91


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.444 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,357,555
Number of Sequences: 37866
Number of extensions: 2493162
Number of successful extensions: 7772
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 5599
Number of HSP's gapped (non-prelim): 854
length of query: 951
length of database: 18,247,518
effective HSP length: 112
effective length of query: 839
effective length of database: 14,006,526
effective search space: 11751475314
effective search space used: 11751475314
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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