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Search of human proteins with 40807504
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40807504 actin filament associated protein 1 [Homo sapiens]
(730 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40807504 actin filament associated protein 1 [Homo sapiens] 1462 0.0
gi|197382472 actin filament associated protein 1 isoform a [Homo... 1170 0.0
gi|55742689 actin filament associated protein 1-like 1 isoform 1... 601 e-172
gi|226437595 actin filament associated protein 1-like 1 isoform ... 580 e-165
gi|50897850 KIAA1914 protein isoform 1 [Homo sapiens] 349 5e-96
gi|24308338 KIAA1914 protein isoform 2 [Homo sapiens] 349 5e-96
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 50 1e-05
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap... 50 1e-05
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi... 50 1e-05
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 47 8e-05
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 46 1e-04
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 46 1e-04
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 45 3e-04
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 45 3e-04
gi|15149465 caldesmon 1 isoform 5 [Homo sapiens] 44 4e-04
gi|15149463 caldesmon 1 isoform 4 [Homo sapiens] 44 4e-04
gi|15149467 caldesmon 1 isoform 3 [Homo sapiens] 44 4e-04
gi|4826657 caldesmon 1 isoform 2 [Homo sapiens] 44 4e-04
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 44 4e-04
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 44 5e-04
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 44 5e-04
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 44 5e-04
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 44 7e-04
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 44 7e-04
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 44 7e-04
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 44 7e-04
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 44 7e-04
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 44 7e-04
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 44 7e-04
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 44 7e-04
>gi|40807504 actin filament associated protein 1 [Homo sapiens]
Length = 730
Score = 1462 bits (3785), Expect = 0.0
Identities = 730/730 (100%), Positives = 730/730 (100%)
Query: 1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP 60
MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
Sbjct: 1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP 60
Query: 61 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS 120
APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
Sbjct: 61 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS 120
Query: 121 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK 180
SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
Sbjct: 121 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK 180
Query: 181 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW 240
LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
Sbjct: 181 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW 240
Query: 241 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE 300
LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
Sbjct: 241 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE 300
Query: 301 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS 360
QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
Sbjct: 301 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS 360
Query: 361 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV 420
RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
Sbjct: 361 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV 420
Query: 421 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA 480
LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
Sbjct: 421 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA 480
Query: 481 NPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPVASNGVTGKGKTLSSQPKKADPA 540
NPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPVASNGVTGKGKTLSSQPKKADPA
Sbjct: 481 NPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPVASNGVTGKGKTLSSQPKKADPA 540
Query: 541 AVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIE 600
AVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIE
Sbjct: 541 AVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIE 600
Query: 601 VNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPK 660
VNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPK
Sbjct: 601 VNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPK 660
Query: 661 SGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAPGSSPCRGHVLRK 720
SGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAPGSSPCRGHVLRK
Sbjct: 661 SGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAPGSSPCRGHVLRK 720
Query: 721 AKEWELKNGT 730
AKEWELKNGT
Sbjct: 721 AKEWELKNGT 730
>gi|197382472 actin filament associated protein 1 isoform a [Homo
sapiens]
Length = 814
Score = 1170 bits (3027), Expect = 0.0
Identities = 623/814 (76%), Positives = 656/814 (80%), Gaps = 84/814 (10%)
Query: 1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP 60
MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP
Sbjct: 1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP 60
Query: 61 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS 120
APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS
Sbjct: 61 APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSS 120
Query: 121 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK 180
SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK
Sbjct: 121 SYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK 180
Query: 181 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW 240
LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW
Sbjct: 181 LLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQW 240
Query: 241 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE 300
LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE
Sbjct: 241 LKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKE 300
Query: 301 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS 360
QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS
Sbjct: 301 QVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS 360
Query: 361 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV 420
RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV
Sbjct: 361 RWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAV 420
Query: 421 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA 480
LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA
Sbjct: 421 LEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISA 480
Query: 481 NPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKK--PPVASNGV--------------- 523
NPYLGGTSNGYAHPSGTALHYDDVPCINGS + + P S G+
Sbjct: 481 NPYLGGTSNGYAHPSGTALHYDDVPCINGSWEPEDGFPASCSRGLGEEVLYDNAGLYDNL 540
Query: 524 ------------TGKGKTLSSQPKKAD----PAAVVKRTGSNA---------AQYKYGK- 557
K LS+ ++ PA+ T +++ +Q K K
Sbjct: 541 PPPHIFARYSPADRKASRLSADKLSSNHYKYPASAQSVTNTSSVGRASLGLNSQLKGKKP 600
Query: 558 ----NRVEADAKRLQTKEEE-----LLKR--KEALRNRLAQLRKERKDLRAAIEVNAGRK 606
N V K L ++ ++ ++KR A + + + R E R + K
Sbjct: 601 PVASNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLK 660
Query: 607 PQAILEEKLKQLEEECRQKEA---------ERVSLELELTEVKESLKKALAGGVT----- 652
+ L +L QL +E + A + LE +L +++E ++ A V+
Sbjct: 661 RKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELEL 720
Query: 653 ----------------LGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVN 696
LGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVN
Sbjct: 721 TEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVN 780
Query: 697 SAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT 730
SAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
Sbjct: 781 SAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT 814
>gi|55742689 actin filament associated protein 1-like 1 isoform 1
[Homo sapiens]
Length = 768
Score = 601 bits (1550), Expect = e-172
Identities = 354/795 (44%), Positives = 466/795 (58%), Gaps = 103/795 (12%)
Query: 1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP 60
+E+L+ EL L LLDHEYL+ T EKK + +IL +Q +V +S P
Sbjct: 7 LEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTADLHSGP 66
Query: 61 APPQ----------MPLPEIPQPWLPPDSG-----------------PPPLPTSSLPEGY 93
+ + L ++P+ P G PPPLP PE Y
Sbjct: 67 SFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNKPPPEDY 126
Query: 94 YEEAVPLSPGKAPEYITSN----------------------------------YDSDAMS 119
YEEA+PL PGK+PEYI+S+ DSDAMS
Sbjct: 127 YEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYNDSDAMS 186
Query: 120 SSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDT 179
SSYESYDEEEE+GK + RHQWPSEEASM LV++ +ICAFLLRKKRFGQW K L VI++
Sbjct: 187 SSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQLTVIRED 246
Query: 180 KLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQ 239
+LLCYKSSKD+QP + L L C+I Y+PKDS+ K+HEL+ TQ T+ LVLA+QS+EQAE+
Sbjct: 247 QLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQSREQAEE 306
Query: 240 WLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGV-VENGITTCNG 298
WLKVI+E G E P P + K +L+K+LS E+ +SD + V V + +T
Sbjct: 307 WLKVIREVSKPVGGAEGVEVPRSPVL-LCKLDLDKRLSQEKQTSDSDSVGVGDNCSTLGR 365
Query: 299 KEQV---KRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDE-QTSSAEEDVPTCGYL 354
+E K KKSS +E KG++S+ G+KIT+II KKK D+ QTSS EE+VP CGYL
Sbjct: 366 RETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVPCCGYL 425
Query: 355 NVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRN 414
NVL N W+ERWCR+K N L FHKD DL+TH+ +I L+GCEV PG +HP FR+LRN
Sbjct: 426 NVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAFRILRN 485
Query: 415 GQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMN 474
QEVA+LEAS SEDMGRW+G+LL E GS PEALHYDY+DVE S++ + +F
Sbjct: 486 RQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNSFL--- 542
Query: 475 RRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPVASNGVTGKGKTLSSQP 534
Y N + P YDDVP + + P + V + S +
Sbjct: 543 --------YARSCQNQWPEPR----VYDDVPYEKMQDEEPERPTGAQ-VKRHASSCSEKS 589
Query: 535 KKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKD 594
+ DP VKR S+A QYKYGKNR E DA+R ++E+L K KE +R L LR+E+++
Sbjct: 590 HRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRE 649
Query: 595 LRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLG 654
L+ AI + G K +A LEE + LE +CR KE R+ LEL+L VKE L+++LAGG LG
Sbjct: 650 LKEAIRSSPGAKLKA-LEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALG 708
Query: 655 LAI--EPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAPGSSP 712
L++ +PKSG ++ N P S E P+PVN + L+K + +S
Sbjct: 709 LSVSSKPKSGETA------------NKP----QNSVPEQPLPVNCVSELRKRSPSIVASN 752
Query: 713 CRGHVLRKAKEWELK 727
+G VL+KAKEWE+K
Sbjct: 753 -QGRVLQKAKEWEMK 766
>gi|226437595 actin filament associated protein 1-like 1 isoform 2
[Homo sapiens]
Length = 725
Score = 580 bits (1495), Expect = e-165
Identities = 333/730 (45%), Positives = 435/730 (59%), Gaps = 86/730 (11%)
Query: 1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLP 60
+E+L+ EL L LLDHEYL+ T EKK + +IL +Q +V +S P
Sbjct: 7 LEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTADLHSGP 66
Query: 61 APPQ----------MPLPEIPQPWLPPDSG-----------------PPPLPTSSLPEGY 93
+ + L ++P+ P G PPPLP PE Y
Sbjct: 67 SFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNKPPPEDY 126
Query: 94 YEEAVPLSPGKAPEYITSN----------------------------------YDSDAMS 119
YEEA+PL PGK+PEYI+S+ DSDAMS
Sbjct: 127 YEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYNDSDAMS 186
Query: 120 SSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDT 179
SSYESYDEEEE+GK + RHQWPSEEASM LV++ +ICAFLLRKKRFGQW K L VI++
Sbjct: 187 SSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQLTVIRED 246
Query: 180 KLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQ 239
+LLCYKSSKD+QP + L L C+I Y+PKDS+ K+HEL+ TQ T+ LVLA+QS+EQAE+
Sbjct: 247 QLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQSREQAEE 306
Query: 240 WLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGV-VENGITTCNG 298
WLKVI+E G E P P + K +L+K+LS E+ +SD + V V + +T
Sbjct: 307 WLKVIREVSKPVGGAEGVEVPRSPVL-LCKLDLDKRLSQEKQTSDSDSVGVGDNCSTLGR 365
Query: 299 KEQV---KRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDE-QTSSAEEDVPTCGYL 354
+E K KKSS +E KG++S+ G+KIT+II KKK D+ QTSS EE+VP CGYL
Sbjct: 366 RETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVPCCGYL 425
Query: 355 NVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRN 414
NVL N W+ERWCR+K N L FHKD DL+TH+ +I L+GCEV PG +HP FR+LRN
Sbjct: 426 NVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAFRILRN 485
Query: 415 GQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMN 474
QEVA+LEAS SEDMGRW+G+LL E GS PEALHYDY+DVE S++ + +F
Sbjct: 486 RQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNSFL--- 542
Query: 475 RRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPVASNGVTGKGKTLSSQP 534
Y N + P YDDVP + + P + V + S +
Sbjct: 543 --------YARSCQNQWPEPR----VYDDVPYEKMQDEEPERPTGAQ-VKRHASSCSEKS 589
Query: 535 KKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKD 594
+ DP VKR S+A QYKYGKNR E DA+R ++E+L K KE +R L LR+E+++
Sbjct: 590 HRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRE 649
Query: 595 LRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLG 654
L+ AI + G K +A LEE + LE +CR KE R+ LEL+L VKE L+++LAGG LG
Sbjct: 650 LKEAIRSSPGAKLKA-LEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALG 708
Query: 655 LAI--EPKSG 662
L++ +PKSG
Sbjct: 709 LSVSSKPKSG 718
>gi|50897850 KIAA1914 protein isoform 1 [Homo sapiens]
Length = 818
Score = 349 bits (896), Expect = 5e-96
Identities = 212/516 (41%), Positives = 293/516 (56%), Gaps = 60/516 (11%)
Query: 1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDV------KDHAQKQE 54
+E+L+ EL FL++LD E L+ST KK+ + +L S D K KQ+
Sbjct: 7 LEQLLTELDDFLKILDQENLSSTALVKKSCLAELLRLYTKSSSSDEEYIYMNKVTINKQQ 66
Query: 55 TANS----------LP--------APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEE 96
A S LP + PQ LP++P P + P+ +P + PEGYYEE
Sbjct: 67 NAESQGKAPEEQGLLPNGEPSQHSSAPQKSLPDLPPPKMIPERKQLAIPKTESPEGYYEE 126
Query: 97 AVPLSPGKAPEYITS-NYDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAK 155
A P Y TS N D +A+SSSYESYDEE+ KGK +QWPS EA ++L++DA+
Sbjct: 127 AEP--------YDTSLNEDGEAVSSSYESYDEED-GSKGKSAPYQWPSPEAGIELMRDAR 177
Query: 156 ICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKH 215
ICAFL RKK GQW K LCVIKD +LLCYKSSKD PQ+++ L G ++ + K +KK+H
Sbjct: 178 ICAFLWRKKWLGQWAKQLCVIKDNRLLCYKSSKDHSPQLDVNLLGSSVIHKEKQVRKKEH 237
Query: 216 ELKITQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCSGPVDSE----CPPPPSSPVHKAE 271
+LKIT D +VL +QSK+QAEQWL+VI+E SG SE P K +
Sbjct: 238 KLKITPMNADVIVLGLQSKDQAEQWLRVIQEV-SGLPSEGASEGNQYTPDAQRFNCQKPD 296
Query: 272 L-EKKLSSERPSSDGEGVVENGITTCNGKEQVKRKKSSKSEAKGTVSKVTGKKITKIISL 330
+ EK LS+ S +G E T + VK+K S+ G K++ +++L
Sbjct: 297 IAEKYLSASEYGSSVDGHPEVPET-----KDVKKKCSA------------GLKLSNLMNL 339
Query: 331 GKKKPSTDEQTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSI 390
G+KK ++ E E + T YLNVL NS+W+ RWC V+DN L F++DR K +
Sbjct: 340 GRKKSTSLE---PVERSLETSSYLNVLVNSQWKSRWCSVRDNHLHFYQDRNRSKVAQQPL 396
Query: 391 PLRGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALH 450
L GCEV+P H +FR+L G+E+A LEA SSE+MG W+G+LL+E+GS TDPE
Sbjct: 397 SLVGCEVVPDPSPDHLYSFRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFT 456
Query: 451 YDYIDVEMSASVIQTAKQTFCFMNRRVISANPYLGG 486
YDY+D + + ++ AK + M R+ N Y+ G
Sbjct: 457 YDYVDADRVSCIVSAAKNSLLLMQRKFSEPNTYIDG 492
Score = 122 bits (306), Expect = 1e-27
Identities = 80/200 (40%), Positives = 114/200 (57%), Gaps = 20/200 (10%)
Query: 534 PKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERK 593
P A P V R +A+ K GKNR EA+ KR ++E L K+KE +R LAQLRKE++
Sbjct: 636 PPGASPP-VKDRLRVTSAEIKLGKNRTEAEVKRYTEEKERLEKKKEEIRGHLAQLRKEKR 694
Query: 594 DLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTL 653
+L+ + ++ A LE+KLK+++EECR +E+ RV LEL + EVK++LKKA AG VTL
Sbjct: 695 ELKETLLKCTDKEVLASLEQKLKEIDEECRGEESRRVDLELSIMEVKDNLKKAEAGPVTL 754
Query: 654 GLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKK---SQAAPGS 710
G ++ T+ ++ R + + + C PVNSA LK S G
Sbjct: 755 GTTVD----TTHLENVSPRPKAVTPASAPDC--------TPVNSATTLKNRPLSVVVTG- 801
Query: 711 SPCRGHVLRKAKEWELKNGT 730
+G VL+KAKEWE K +
Sbjct: 802 ---KGTVLQKAKEWEKKGAS 818
>gi|24308338 KIAA1914 protein isoform 2 [Homo sapiens]
Length = 814
Score = 349 bits (896), Expect = 5e-96
Identities = 212/516 (41%), Positives = 293/516 (56%), Gaps = 60/516 (11%)
Query: 1 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDV------KDHAQKQE 54
+E+L+ EL FL++LD E L+ST KK+ + +L S D K KQ+
Sbjct: 7 LEQLLTELDDFLKILDQENLSSTALVKKSCLAELLRLYTKSSSSDEEYIYMNKVTINKQQ 66
Query: 55 TANS----------LP--------APPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEE 96
A S LP + PQ LP++P P + P+ +P + PEGYYEE
Sbjct: 67 NAESQGKAPEEQGLLPNGEPSQHSSAPQKSLPDLPPPKMIPERKQLAIPKTESPEGYYEE 126
Query: 97 AVPLSPGKAPEYITS-NYDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAK 155
A P Y TS N D +A+SSSYESYDEE+ KGK +QWPS EA ++L++DA+
Sbjct: 127 AEP--------YDTSLNEDGEAVSSSYESYDEED-GSKGKSAPYQWPSPEAGIELMRDAR 177
Query: 156 ICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKH 215
ICAFL RKK GQW K LCVIKD +LLCYKSSKD PQ+++ L G ++ + K +KK+H
Sbjct: 178 ICAFLWRKKWLGQWAKQLCVIKDNRLLCYKSSKDHSPQLDVNLLGSSVIHKEKQVRKKEH 237
Query: 216 ELKITQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCSGPVDSE----CPPPPSSPVHKAE 271
+LKIT D +VL +QSK+QAEQWL+VI+E SG SE P K +
Sbjct: 238 KLKITPMNADVIVLGLQSKDQAEQWLRVIQEV-SGLPSEGASEGNQYTPDAQRFNCQKPD 296
Query: 272 L-EKKLSSERPSSDGEGVVENGITTCNGKEQVKRKKSSKSEAKGTVSKVTGKKITKIISL 330
+ EK LS+ S +G E T + VK+K S+ G K++ +++L
Sbjct: 297 IAEKYLSASEYGSSVDGHPEVPET-----KDVKKKCSA------------GLKLSNLMNL 339
Query: 331 GKKKPSTDEQTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSI 390
G+KK ++ E E + T YLNVL NS+W+ RWC V+DN L F++DR K +
Sbjct: 340 GRKKSTSLE---PVERSLETSSYLNVLVNSQWKSRWCSVRDNHLHFYQDRNRSKVAQQPL 396
Query: 391 PLRGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALH 450
L GCEV+P H +FR+L G+E+A LEA SSE+MG W+G+LL+E+GS TDPE
Sbjct: 397 SLVGCEVVPDPSPDHLYSFRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFT 456
Query: 451 YDYIDVEMSASVIQTAKQTFCFMNRRVISANPYLGG 486
YDY+D + + ++ AK + M R+ N Y+ G
Sbjct: 457 YDYVDADRVSCIVSAAKNSLLLMQRKFSEPNTYIDG 492
Score = 122 bits (305), Expect = 2e-27
Identities = 82/200 (41%), Positives = 116/200 (58%), Gaps = 24/200 (12%)
Query: 534 PKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERK 593
P A P V R +A+ K GKNR EA+ KR ++E L K+KE +R LAQLRKE++
Sbjct: 636 PPGASPP-VKDRLRVTSAEIKLGKNRTEAEVKRYTEEKERLEKKKEEIRGHLAQLRKEKR 694
Query: 594 DLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTL 653
+L+ + ++ A LE+KLK+++EECR +E+ RV LEL + EVK++LKKA AG VTL
Sbjct: 695 ELKETLLKCTDKEVLASLEQKLKEIDEECRGEESRRVDLELSIMEVKDNLKKAEAGPVTL 754
Query: 654 GLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKK---SQAAPGS 710
G ++ T+ ++P +P S+ D + PVNSA LK S G
Sbjct: 755 GTTVD----TTHLENP------KAVTPASAPDCT------PVNSATTLKNRPLSVVVTG- 797
Query: 711 SPCRGHVLRKAKEWELKNGT 730
+G VL+KAKEWE K +
Sbjct: 798 ---KGTVLQKAKEWEKKGAS 814
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 49.7 bits (117), Expect = 1e-05
Identities = 47/176 (26%), Positives = 76/176 (43%), Gaps = 24/176 (13%)
Query: 101 SPGKAPEYITSNYDSDAMSSSYESYDEEEEDG--------------KGKKTRHQWPSEEA 146
S APE++ S+ + + D+E ED +G H
Sbjct: 861 SSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNT 920
Query: 147 SMDLVK-----DAKICAFLLRK-KRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQG 200
S+ +V + ++ LLRK K W KL V + L YKS +D P LPL G
Sbjct: 921 SVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLG 980
Query: 201 CNITYIPKDSK--KKKHELKITQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCSGP 254
++T IP +S+ +K + K+ + + +S+ E+W++VI+ A S S P
Sbjct: 981 YSLT-IPSESENIQKDYVFKLHFK-SHVYYFRAESEYTFERWMEVIRSATSSASRP 1034
>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
sapiens]
Length = 645
Score = 49.7 bits (117), Expect = 1e-05
Identities = 36/150 (24%), Positives = 67/150 (44%), Gaps = 16/150 (10%)
Query: 501 YDDVPCINGSLKGKKPPVASNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRV 560
YD+VP + GS + ++S KG TL+S + P + G+ +
Sbjct: 502 YDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGP-----------GKKNSGEEEI 550
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAI-----EVNAGRKPQAILEEKL 615
++ + +Q +E+ +K+ ++ L KE D+ A + E+ +K A LE L
Sbjct: 551 DSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAALEISL 610
Query: 616 KQLEEECRQKEAERVSLELELTEVKESLKK 645
+ +E E +LE E+ E +S+K+
Sbjct: 611 RNMERSREDVEKRNKALEEEVKEFVKSMKE 640
Score = 39.3 bits (90), Expect = 0.013
Identities = 27/95 (28%), Positives = 47/95 (49%), Gaps = 10/95 (10%)
Query: 161 LRKKR--FGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYI---PKDSKKKKH 215
L+K+R W + V++ +L YK +D +PQ + L GC I I P+++ K
Sbjct: 53 LKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVF 112
Query: 216 EL-----KITQQGTDPLVLAVQSKEQAEQWLKVIK 245
E+ + G D VL S+ + E+W+K ++
Sbjct: 113 EIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLR 147
Score = 36.2 bits (82), Expect = 0.11
Identities = 25/97 (25%), Positives = 41/97 (42%), Gaps = 23/97 (23%)
Query: 362 WRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKH---------------- 405
W++R+ ++ +L ++KD D K +GC +PG K
Sbjct: 63 WQQRYFVLRAQQLYYYKDEEDTKP-------QGCMYLPGCTIKEIATNPEEAGKFVFEII 115
Query: 406 PLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGS 442
P ++ R GQ+ VL ASS +M W+ L G+
Sbjct: 116 PASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGT 152
>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
sapiens]
Length = 638
Score = 49.7 bits (117), Expect = 1e-05
Identities = 36/150 (24%), Positives = 67/150 (44%), Gaps = 16/150 (10%)
Query: 501 YDDVPCINGSLKGKKPPVASNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRV 560
YD+VP + GS + ++S KG TL+S + P + G+ +
Sbjct: 495 YDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGP-----------GKKNSGEEEI 543
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAI-----EVNAGRKPQAILEEKL 615
++ + +Q +E+ +K+ ++ L KE D+ A + E+ +K A LE L
Sbjct: 544 DSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAALEISL 603
Query: 616 KQLEEECRQKEAERVSLELELTEVKESLKK 645
+ +E E +LE E+ E +S+K+
Sbjct: 604 RNMERSREDVEKRNKALEEEVKEFVKSMKE 633
Score = 39.3 bits (90), Expect = 0.013
Identities = 27/95 (28%), Positives = 47/95 (49%), Gaps = 10/95 (10%)
Query: 161 LRKKR--FGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYI---PKDSKKKKH 215
L+K+R W + V++ +L YK +D +PQ + L GC I I P+++ K
Sbjct: 46 LKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVF 105
Query: 216 EL-----KITQQGTDPLVLAVQSKEQAEQWLKVIK 245
E+ + G D VL S+ + E+W+K ++
Sbjct: 106 EIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLR 140
Score = 36.2 bits (82), Expect = 0.11
Identities = 25/97 (25%), Positives = 41/97 (42%), Gaps = 23/97 (23%)
Query: 362 WRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKH---------------- 405
W++R+ ++ +L ++KD D K +GC +PG K
Sbjct: 56 WQQRYFVLRAQQLYYYKDEEDTKP-------QGCMYLPGCTIKEIATNPEEAGKFVFEII 108
Query: 406 PLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGS 442
P ++ R GQ+ VL ASS +M W+ L G+
Sbjct: 109 PASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGT 145
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 46.6 bits (109), Expect = 8e-05
Identities = 52/232 (22%), Positives = 92/232 (39%), Gaps = 29/232 (12%)
Query: 95 EEAVPLSPGKAPEYITSNYDSDAMSSSYESYDEEEEDGKGKKTRH--QWPSEEASMDLVK 152
+E + L+ + + D ++ ++S + E E K + P ++ L+
Sbjct: 412 QEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTASSPKDQEKYGLLN 471
Query: 153 DAKICAFLLRKKRFGQWTKLLCVIKDTKLLCYKS---------SKDQQPQMELPLQGCNI 203
KI KK W V++ + LL K+ S +P+ + L+G I
Sbjct: 472 VTKIAEN--GKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATI 529
Query: 204 TYIPKDSKKKKH--ELKITQQGTDPLVLAVQSKEQAEQWLKVIKEAYSG----CSGPVDS 257
KD KK+ ELK T+QGT+ L++ + W KV+ + ++
Sbjct: 530 EMASKDKSSKKNVFELK-TRQGTE-LLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEE 587
Query: 258 ECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKEQVKRKKSSK 309
E P P H E E+K D + + +++ + EQ K KK+ K
Sbjct: 588 EIPDSPGIEKHDKEKEQK--------DPKKLRSFKVSSIDSSEQKKTKKNLK 631
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 46.2 bits (108), Expect = 1e-04
Identities = 38/128 (29%), Positives = 59/128 (46%), Gaps = 12/128 (9%)
Query: 126 DEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTK---LL 182
D EE+ KG E S ++ ++ +C+FL ++ W K CVI L
Sbjct: 623 DSEEKKRKGIL-------EIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLY 675
Query: 183 CYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQWLK 242
Y + +D + Q +PL G + +P+ S H K+T Q A S+E ++WLK
Sbjct: 676 MYGAPQDVRAQATIPLLGYVVDEMPR-SADLPHSFKLT-QSKSVHSFAADSEELKQKWLK 733
Query: 243 VIKEAYSG 250
VI A +G
Sbjct: 734 VILLAVTG 741
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 45.8 bits (107), Expect = 1e-04
Identities = 23/102 (22%), Positives = 57/102 (55%)
Query: 544 KRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNA 603
++ G Q + + ++ +++Q +EE++ K++E +R + Q+R++ + +R E
Sbjct: 220 EQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQML 279
Query: 604 GRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKK 645
+K Q EE+ + EE+ R++E + E ++ E +E +++
Sbjct: 280 KQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMRE 321
Score = 42.7 bits (99), Expect = 0.001
Identities = 20/89 (22%), Positives = 51/89 (57%)
Query: 557 KNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLK 616
+ +V+ +++Q +EE++ K++E +R + Q+R++ + + E + EE+++
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMR 299
Query: 617 QLEEECRQKEAERVSLELELTEVKESLKK 645
+ EE+ R++E + E ++ E +E + K
Sbjct: 300 EQEEQMREQEEQMREQEEQMREQEEQMGK 328
Score = 38.1 bits (87), Expect = 0.029
Identities = 17/100 (17%), Positives = 54/100 (54%)
Query: 544 KRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNA 603
++ G Q + + +V+ ++++ +EE++ +++E +R + Q+ K+++ +
Sbjct: 234 EQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGE 293
Query: 604 GRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESL 643
+ EE++++ EE+ R++E + E ++ + +E +
Sbjct: 294 QEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQM 333
Score = 36.6 bits (83), Expect = 0.085
Identities = 20/78 (25%), Positives = 46/78 (58%), Gaps = 1/78 (1%)
Query: 565 KRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQ-AILEEKLKQLEEECR 623
+++Q +EE++ K++E +R + Q+RK+ + +R E +K Q +E++++ EE+
Sbjct: 359 EQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMG 418
Query: 624 QKEAERVSLELELTEVKE 641
+++ + E + E KE
Sbjct: 419 EQKEQMRKQEEHMGEQKE 436
Score = 34.3 bits (77), Expect = 0.42
Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 557 KNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLK 616
K ++ +++ +EE++ K++E +R + Q+RK+ + +R E RK + + E+ +
Sbjct: 344 KEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEE--QMRKQEEQMGEQKE 401
Query: 617 QLEEECRQKEAERVSLELELTEVKESLKK 645
Q+ E QKE R E ++ E KE ++K
Sbjct: 402 QMGE---QKEQMR-EQEEQMGEQKEQMRK 426
Score = 33.5 bits (75), Expect = 0.72
Identities = 19/112 (16%), Positives = 61/112 (54%), Gaps = 1/112 (0%)
Query: 535 KKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKD 594
K+ + ++TG Q + + ++ ++++ +EE++ +++E + + Q+ ++++
Sbjct: 280 KQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQ 339
Query: 595 LRAAIEVNAGRKPQ-AILEEKLKQLEEECRQKEAERVSLELELTEVKESLKK 645
+ E ++ Q EE++++ EE+ R++E + E ++ + +E ++K
Sbjct: 340 MWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRK 391
Score = 32.7 bits (73), Expect = 1.2
Identities = 19/102 (18%), Positives = 53/102 (51%), Gaps = 13/102 (12%)
Query: 544 KRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNA 603
++ G Q K ++ +++ +EE++ +++E ++ + Q+RK+ + +R
Sbjct: 324 EQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQ----- 378
Query: 604 GRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKK 645
EE++++ EE+ R++E + + ++ E KE +++
Sbjct: 379 --------EEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMRE 412
Score = 32.0 bits (71), Expect = 2.1
Identities = 18/82 (21%), Positives = 46/82 (56%), Gaps = 1/82 (1%)
Query: 565 KRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIE-VNAGRKPQAILEEKLKQLEEECR 623
+++ +EE++ K++E + + Q+RK+ + + E V + EE++++ EE+ R
Sbjct: 206 EQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMR 265
Query: 624 QKEAERVSLELELTEVKESLKK 645
++E + E ++ + KE ++
Sbjct: 266 EQEEQMREQEEQMLKQKEQTEQ 287
Score = 31.6 bits (70), Expect = 2.7
Identities = 19/93 (20%), Positives = 50/93 (53%), Gaps = 1/93 (1%)
Query: 552 QYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQA-I 610
Q + + ++ +++ +EE++ ++KE + + Q+ K+ + + E ++ Q
Sbjct: 311 QMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRK 370
Query: 611 LEEKLKQLEEECRQKEAERVSLELELTEVKESL 643
EE++++ EE+ R++E + E ++ E KE +
Sbjct: 371 QEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQM 403
Score = 31.6 bits (70), Expect = 2.7
Identities = 16/71 (22%), Positives = 43/71 (60%), Gaps = 1/71 (1%)
Query: 557 KNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQ-AILEEKL 615
+ +++ ++++ +EE++ K++E +R + Q+RK+ + + E +K Q EE++
Sbjct: 358 EEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQM 417
Query: 616 KQLEEECRQKE 626
+ +E+ R++E
Sbjct: 418 GEQKEQMRKQE 428
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 44.7 bits (104), Expect = 3e-04
Identities = 46/173 (26%), Positives = 74/173 (42%), Gaps = 11/173 (6%)
Query: 102 PGKAPEYITSNYDSDAMSSSYESYDEEEEDGKGKKTRHQ-W----PSEEASMDLVKDAKI 156
P ++P ++ +S+ + S E + T H W A + ++
Sbjct: 873 PPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMHVCWYRNTSVSRADHSAAVENQL 932
Query: 157 CAFLLRK-KRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPK--DSKKK 213
+LLRK K W KL V + L YK+ +D P LPL G +++ IP+ D K
Sbjct: 933 SGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVS-IPREADGIHK 991
Query: 214 KHELKITQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCS-GPVDSECPPPPSS 265
+ K+ Q + +SK E+W++VI+ A S P + P PSS
Sbjct: 992 DYVFKL-QFKSHVYFFRAESKYTFERWMEVIQGASSSAGRAPSIVQDGPQPSS 1043
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 44.7 bits (104), Expect = 3e-04
Identities = 38/143 (26%), Positives = 54/143 (37%), Gaps = 26/143 (18%)
Query: 168 QWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYI-PKDSKKKKHELKITQQGTDP 226
QW K V+ D L YK K++ +PL + + P D+ +KH K G
Sbjct: 76 QWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRT 135
Query: 227 LVLAVQSKEQAEQWLKVIKEAYSGCSGPV---------------DSECPP-------PPS 264
+ +S E+ E W++ + EA P DSE P PP
Sbjct: 136 YFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPH 195
Query: 265 SPVHKAELEKKLSSERPSSDGEG 287
+ + K E E K E DG G
Sbjct: 196 NSLPKPEPEAKTRGE---GDGRG 215
Score = 34.7 bits (78), Expect = 0.32
Identities = 30/114 (26%), Positives = 50/114 (43%), Gaps = 10/114 (8%)
Query: 326 KIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNS---RWRERWCRVKDNKLIFHKDRTD 382
K ++ GK+ S ++ V G+L ++S +W +RW + D L ++KD +
Sbjct: 41 KAVAFGKRSHSMKRNPNAP---VTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKE 97
Query: 383 LKTHIVSIPL---RGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWI 433
++ + SIPL R V P + TF+ G A S E+ WI
Sbjct: 98 -ESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWI 150
>gi|15149465 caldesmon 1 isoform 5 [Homo sapiens]
Length = 532
Score = 44.3 bits (103), Expect = 4e-04
Identities = 33/116 (28%), Positives = 56/116 (48%), Gaps = 7/116 (6%)
Query: 540 AAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRN---RLAQLRKERKDLR 596
A+V + A Q + GK E +R +T+ EE K K+ + L +L+K+R++ R
Sbjct: 256 ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR 315
Query: 597 AAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVT 652
+E R+ Q + KL++ EE+ R KE +E E E +K G++
Sbjct: 316 KVLEEEEQRRKQEEADRKLREEEEKRRLKE----EIERRRAEAAEKRQKMPEDGLS 367
>gi|15149463 caldesmon 1 isoform 4 [Homo sapiens]
Length = 558
Score = 44.3 bits (103), Expect = 4e-04
Identities = 33/116 (28%), Positives = 56/116 (48%), Gaps = 7/116 (6%)
Query: 540 AAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRN---RLAQLRKERKDLR 596
A+V + A Q + GK E +R +T+ EE K K+ + L +L+K+R++ R
Sbjct: 282 ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR 341
Query: 597 AAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVT 652
+E R+ Q + KL++ EE+ R KE +E E E +K G++
Sbjct: 342 KVLEEEEQRRKQEEADRKLREEEEKRRLKE----EIERRRAEAAEKRQKMPEDGLS 393
>gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]
Length = 564
Score = 44.3 bits (103), Expect = 4e-04
Identities = 33/116 (28%), Positives = 56/116 (48%), Gaps = 7/116 (6%)
Query: 540 AAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRN---RLAQLRKERKDLR 596
A+V + A Q + GK E +R +T+ EE K K+ + L +L+K+R++ R
Sbjct: 288 ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR 347
Query: 597 AAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVT 652
+E R+ Q + KL++ EE+ R KE +E E E +K G++
Sbjct: 348 KVLEEEEQRRKQEEADRKLREEEEKRRLKE----EIERRRAEAAEKRQKMPEDGLS 399
>gi|4826657 caldesmon 1 isoform 2 [Homo sapiens]
Length = 538
Score = 44.3 bits (103), Expect = 4e-04
Identities = 33/116 (28%), Positives = 56/116 (48%), Gaps = 7/116 (6%)
Query: 540 AAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRN---RLAQLRKERKDLR 596
A+V + A Q + GK E +R +T+ EE K K+ + L +L+K+R++ R
Sbjct: 262 ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR 321
Query: 597 AAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVT 652
+E R+ Q + KL++ EE+ R KE +E E E +K G++
Sbjct: 322 KVLEEEEQRRKQEEADRKLREEEEKRRLKE----EIERRRAEAAEKRQKMPEDGLS 373
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 44.3 bits (103), Expect = 4e-04
Identities = 33/116 (28%), Positives = 56/116 (48%), Gaps = 7/116 (6%)
Query: 540 AAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRN---RLAQLRKERKDLR 596
A+V + A Q + GK E +R +T+ EE K K+ + L +L+K+R++ R
Sbjct: 517 ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR 576
Query: 597 AAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVT 652
+E R+ Q + KL++ EE+ R KE +E E E +K G++
Sbjct: 577 KVLEEEEQRRKQEEADRKLREEEEKRRLKE----EIERRRAEAAEKRQKMPEDGLS 628
Score = 32.0 bits (71), Expect = 2.1
Identities = 26/88 (29%), Positives = 43/88 (48%), Gaps = 3/88 (3%)
Query: 559 RVEADAKRL-QTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQ 617
R+EA+ K Q +E + +E +R + +ER+ ++ E A + Q I EE+ +
Sbjct: 294 RIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEE-EKRAAEERQRIKEEEKRA 352
Query: 618 LEEECRQKEAE-RVSLELELTEVKESLK 644
EE R KE E R + E + +E K
Sbjct: 353 AEERQRIKEEEKRAAEERQRARAEEEEK 380
Score = 32.0 bits (71), Expect = 2.1
Identities = 20/108 (18%), Positives = 56/108 (51%), Gaps = 2/108 (1%)
Query: 544 KRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNA 603
+R + + + R + +R++ +E+ + ++ ++ + +ER+ ++ + A
Sbjct: 308 RREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA 367
Query: 604 GRKPQAILEEKLK-QLEEECRQKEAERVSLELELTEVK-ESLKKALAG 649
+ +A EE+ K ++EE+ R K+ E ++ T++K E +++ + G
Sbjct: 368 EERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEG 415
Score = 30.4 bits (67), Expect = 6.1
Identities = 35/149 (23%), Positives = 64/149 (42%), Gaps = 31/149 (20%)
Query: 527 GKTLSSQPKKADPAAVVKRTGSNAAQY-----KYGKNRVEADAKRLQTKEEELLK----- 576
G+ S +PK+ + + GS+ + + K R EA+ RL+ +E E +K
Sbjct: 231 GQISSEEPKQEEE----REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDK 286
Query: 577 -------RKEALRNRLAQLRKERK----------DLRAAIEVNAGRKPQAILEEKLKQLE 619
R EA AQ R+ R+ + RAA E ++ + E+ ++++
Sbjct: 287 KIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIK 346
Query: 620 EECRQKEAERVSLELELTEVKESLKKALA 648
EE ++ ER ++ E E ++A A
Sbjct: 347 EEEKRAAEERQRIKEEEKRAAEERQRARA 375
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 43.9 bits (102), Expect = 5e-04
Identities = 38/139 (27%), Positives = 68/139 (48%), Gaps = 21/139 (15%)
Query: 530 LSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKE-------EELLKRKEALR 582
L + KK D ++T S A+Y ++R EA+A+ +TK EE +++K L
Sbjct: 1439 LEKKQKKFDQLLAEEKTIS--AKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE 1496
Query: 583 NRLAQLRKERKDLRAAIE-----VNAGRKPQAILEE-------KLKQLEEECRQKEAERV 630
Q R E +DL ++ + V+ K + LE+ +L++LE+E + E ++
Sbjct: 1497 RLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL 1556
Query: 631 SLELELTEVKESLKKALAG 649
LE+ L +K ++ L G
Sbjct: 1557 RLEVNLQAMKAQFERDLQG 1575
Score = 37.7 bits (86), Expect = 0.038
Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 14/96 (14%)
Query: 564 AKRLQTKEE-----ELLKRKEALRNRLAQLRKERK----DLRAAIEVNAGRKPQAILEEK 614
A++LQ +E+ EL E LR RL ++E + DL A +E R E+K
Sbjct: 880 AEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 615 -----LKQLEEECRQKEAERVSLELELTEVKESLKK 645
+++LEE+ ++E+ R L+LE + LKK
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKK 975
Score = 34.3 bits (77), Expect = 0.42
Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 17/115 (14%)
Query: 547 GSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNA-GR 605
G + + + K +E + ++T+ EEL +A + +L + ++A E + GR
Sbjct: 1517 GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGR 1576
Query: 606 KPQAILEEKLKQLEEECRQKEAE--------------RVSLELELTEVKESLKKA 646
Q+ EEK KQL + R+ EAE R LE++L +++ + A
Sbjct: 1577 DEQS--EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSA 1629
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 43.9 bits (102), Expect = 5e-04
Identities = 40/180 (22%), Positives = 85/180 (47%), Gaps = 15/180 (8%)
Query: 528 KTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQ 587
K + ++ AA KR Q + + R E + + + +E+E +++ L + +
Sbjct: 666 KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQ--E 723
Query: 588 LRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKAL 647
R+E++ L+A E+ K + +E+L++ EE ++KE ++ E +L E +E K
Sbjct: 724 RRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
Query: 648 AG---GVTLGLAIEPKSGTSSPQSPVFRHRTLENSP------ISSCDTSDTEG----PVP 694
AG + + + ++ + TS +P + +P ++S D++D E P+P
Sbjct: 784 AGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIP 843
Score = 36.2 bits (82), Expect = 0.11
Identities = 28/82 (34%), Positives = 46/82 (56%), Gaps = 4/82 (4%)
Query: 567 LQTKEEELLKR--KEALRNRLAQLRKE--RKDLRAAIEVNAGRKPQAILEEKLKQLEEEC 622
LQ K+EE +R K A RLA+ R++ R+ R E + + E+ +QL E+
Sbjct: 664 LQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQE 723
Query: 623 RQKEAERVSLELELTEVKESLK 644
R++E ER+ E EL E +++L+
Sbjct: 724 RRREQERLQAERELQEREKALR 745
Score = 32.3 bits (72), Expect = 1.6
Identities = 27/96 (28%), Positives = 52/96 (54%), Gaps = 8/96 (8%)
Query: 560 VEADAKRLQT----KEEELLKRK---EALRNRLAQLRKERKDLRAAIEVNAGRKPQAILE 612
VE + +RL+ +E E L+R+ E R RL +++ +R++ R + A + + + E
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE-RLRKVLQARERVEQMKE 593
Query: 613 EKLKQLEEECRQKEAERVSLELELTEVKESLKKALA 648
EK KQ+E++ Q + + + E +++ KKA A
Sbjct: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA 629
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 43.9 bits (102), Expect = 5e-04
Identities = 40/180 (22%), Positives = 85/180 (47%), Gaps = 15/180 (8%)
Query: 528 KTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQ 587
K + ++ AA KR Q + + R E + + + +E+E +++ L + +
Sbjct: 662 KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQ--E 719
Query: 588 LRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKAL 647
R+E++ L+A E+ K + +E+L++ EE ++KE ++ E +L E +E K
Sbjct: 720 RRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
Query: 648 AG---GVTLGLAIEPKSGTSSPQSPVFRHRTLENSP------ISSCDTSDTEG----PVP 694
AG + + + ++ + TS +P + +P ++S D++D E P+P
Sbjct: 780 AGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIP 839
Score = 36.2 bits (82), Expect = 0.11
Identities = 28/82 (34%), Positives = 46/82 (56%), Gaps = 4/82 (4%)
Query: 567 LQTKEEELLKR--KEALRNRLAQLRKE--RKDLRAAIEVNAGRKPQAILEEKLKQLEEEC 622
LQ K+EE +R K A RLA+ R++ R+ R E + + E+ +QL E+
Sbjct: 660 LQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQE 719
Query: 623 RQKEAERVSLELELTEVKESLK 644
R++E ER+ E EL E +++L+
Sbjct: 720 RRREQERLQAERELQEREKALR 741
Score = 32.7 bits (73), Expect = 1.2
Identities = 26/120 (21%), Positives = 59/120 (49%), Gaps = 1/120 (0%)
Query: 529 TLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQL 588
T +S P+ + + + T + + R+E ++ + ++ K +E R RL ++
Sbjct: 507 TPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEV 566
Query: 589 RKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALA 648
+ +R++ R + A + + + EEK KQ+E++ Q + + + E +++ KKA A
Sbjct: 567 KLKREE-RLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA 625
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/110 (25%), Positives = 53/110 (48%), Gaps = 12/110 (10%)
Query: 551 AQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRK------------ERKDLRAA 598
A+ + K E +A+R EE+ ++++E L + R+ E++ +R
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719
Query: 599 IEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALA 648
E G + + +LEE+L +L+ E +R LE EL +V+ ++ LA
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769
Score = 36.6 bits (83), Expect = 0.085
Identities = 30/108 (27%), Positives = 54/108 (50%), Gaps = 11/108 (10%)
Query: 537 ADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTK-EEELLKRKEALRNRLAQLRKERKDL 595
A+ A +++ A + K + E +AK LQ + +EE+++R+EA + Q R +++L
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422
Query: 596 R-----AAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTE 638
+ + E+ A + E ++EEE R V L+LE TE
Sbjct: 1423 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV-----VRLQLEATE 1465
Score = 33.9 bits (76), Expect = 0.55
Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 6/91 (6%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRK----ERKDLRAAIEVNAGRKPQAILEEKLK 616
E +A + + EE+ + K + RLAQLRK E + + +E ++ Q +EE++
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ--VEEEIL 1928
Query: 617 QLEEECRQKEAERVSLELELTEVKESLKKAL 647
L+ + A + LELEL ++ + + L
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Score = 32.3 bits (72), Expect = 1.6
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 16/136 (11%)
Query: 528 KTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEE--------LLKRKE 579
+TL Q +++D A +R A+ + K +++ +AK LQ K EE LL+ +
Sbjct: 2432 QTLEIQRQQSDHDA--ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489
Query: 580 ALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEE--KLKQLEEE----CRQKEAERVSLE 633
AL+ + IE + Q +E K +QL EE +Q E ER L
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 634 LELTEVKESLKKALAG 649
+ E + +A G
Sbjct: 2550 ASMEEARRRQHEAEEG 2565
Score = 32.0 bits (71), Expect = 2.1
Identities = 26/91 (28%), Positives = 47/91 (51%), Gaps = 9/91 (9%)
Query: 562 ADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEE 621
A A++L+ +++ ++ E R RL +E + + E RK +E+L+QLE++
Sbjct: 2525 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK-----QEELQQLEQQ 2579
Query: 622 CRQKE----AERVSLELELTEVKESLKKALA 648
RQ+E E L +L ++E + ALA
Sbjct: 2580 RRQQEELLAEENQRLREQLQLLEEQHRAALA 2610
Score = 30.8 bits (68), Expect = 4.7
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 4/89 (4%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILE--EKLKQL 618
+A A +Q KE+EL + + ++ L QLR E + R A E + QA E + +Q+
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Query: 619 EEECRQKEA--ERVSLELELTEVKESLKK 645
EE R K++ E+ + E L+K
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Score = 30.0 bits (66), Expect = 8.0
Identities = 18/82 (21%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 268 HKAELEKKLSSERPSSDGEGVVENGITTCNGKEQVKRKKSSKSE---AKGTVSKVTGKKI 324
HKA++E++L+ R +SD E + G+ ++ +++++ + E K + K K
Sbjct: 1887 HKADIEERLAQLRKASDSELERQKGLV----EDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 325 TKIISLGKKKPSTDEQTSSAEE 346
+ LG+ + + ++ S E+
Sbjct: 1943 ELELELGRIRSNAEDTLRSKEQ 1964
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/110 (25%), Positives = 53/110 (48%), Gaps = 12/110 (10%)
Query: 551 AQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRK------------ERKDLRAA 598
A+ + K E +A+R EE+ ++++E L + R+ E++ +R
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1723
Query: 599 IEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALA 648
E G + + +LEE+L +L+ E +R LE EL +V+ ++ LA
Sbjct: 1724 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1773
Score = 36.6 bits (83), Expect = 0.085
Identities = 30/108 (27%), Positives = 54/108 (50%), Gaps = 11/108 (10%)
Query: 537 ADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTK-EEELLKRKEALRNRLAQLRKERKDL 595
A+ A +++ A + K + E +AK LQ + +EE+++R+EA + Q R +++L
Sbjct: 1367 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1426
Query: 596 R-----AAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTE 638
+ + E+ A + E ++EEE R V L+LE TE
Sbjct: 1427 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV-----VRLQLEATE 1469
Score = 33.9 bits (76), Expect = 0.55
Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 6/91 (6%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRK----ERKDLRAAIEVNAGRKPQAILEEKLK 616
E +A + + EE+ + K + RLAQLRK E + + +E ++ Q +EE++
Sbjct: 1875 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ--VEEEIL 1932
Query: 617 QLEEECRQKEAERVSLELELTEVKESLKKAL 647
L+ + A + LELEL ++ + + L
Sbjct: 1933 ALKASFEKAAAGKAELELELGRIRSNAEDTL 1963
Score = 32.3 bits (72), Expect = 1.6
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 16/136 (11%)
Query: 528 KTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEE--------LLKRKE 579
+TL Q +++D A +R A+ + K +++ +AK LQ K EE LL+ +
Sbjct: 2436 QTLEIQRQQSDHDA--ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2493
Query: 580 ALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEE--KLKQLEEE----CRQKEAERVSLE 633
AL+ + IE + Q +E K +QL EE +Q E ER L
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553
Query: 634 LELTEVKESLKKALAG 649
+ E + +A G
Sbjct: 2554 ASMEEARRRQHEAEEG 2569
Score = 32.0 bits (71), Expect = 2.1
Identities = 26/91 (28%), Positives = 47/91 (51%), Gaps = 9/91 (9%)
Query: 562 ADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEE 621
A A++L+ +++ ++ E R RL +E + + E RK +E+L+QLE++
Sbjct: 2529 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK-----QEELQQLEQQ 2583
Query: 622 CRQKE----AERVSLELELTEVKESLKKALA 648
RQ+E E L +L ++E + ALA
Sbjct: 2584 RRQQEELLAEENQRLREQLQLLEEQHRAALA 2614
Score = 30.8 bits (68), Expect = 4.7
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 4/89 (4%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILE--EKLKQL 618
+A A +Q KE+EL + + ++ L QLR E + R A E + QA E + +Q+
Sbjct: 2056 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2115
Query: 619 EEECRQKEA--ERVSLELELTEVKESLKK 645
EE R K++ E+ + E L+K
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRK 2144
Score = 30.0 bits (66), Expect = 8.0
Identities = 18/82 (21%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 268 HKAELEKKLSSERPSSDGEGVVENGITTCNGKEQVKRKKSSKSE---AKGTVSKVTGKKI 324
HKA++E++L+ R +SD E + G+ ++ +++++ + E K + K K
Sbjct: 1891 HKADIEERLAQLRKASDSELERQKGLV----EDTLRQRRQVEEEILALKASFEKAAAGKA 1946
Query: 325 TKIISLGKKKPSTDEQTSSAEE 346
+ LG+ + + ++ S E+
Sbjct: 1947 ELELELGRIRSNAEDTLRSKEQ 1968
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/110 (25%), Positives = 53/110 (48%), Gaps = 12/110 (10%)
Query: 551 AQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRK------------ERKDLRAA 598
A+ + K E +A+R EE+ ++++E L + R+ E++ +R
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719
Query: 599 IEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALA 648
E G + + +LEE+L +L+ E +R LE EL +V+ ++ LA
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769
Score = 36.6 bits (83), Expect = 0.085
Identities = 30/108 (27%), Positives = 54/108 (50%), Gaps = 11/108 (10%)
Query: 537 ADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTK-EEELLKRKEALRNRLAQLRKERKDL 595
A+ A +++ A + K + E +AK LQ + +EE+++R+EA + Q R +++L
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422
Query: 596 R-----AAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTE 638
+ + E+ A + E ++EEE R V L+LE TE
Sbjct: 1423 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV-----VRLQLEATE 1465
Score = 33.9 bits (76), Expect = 0.55
Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 6/91 (6%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRK----ERKDLRAAIEVNAGRKPQAILEEKLK 616
E +A + + EE+ + K + RLAQLRK E + + +E ++ Q +EE++
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ--VEEEIL 1928
Query: 617 QLEEECRQKEAERVSLELELTEVKESLKKAL 647
L+ + A + LELEL ++ + + L
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Score = 32.3 bits (72), Expect = 1.6
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 16/136 (11%)
Query: 528 KTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEE--------LLKRKE 579
+TL Q +++D A +R A+ + K +++ +AK LQ K EE LL+ +
Sbjct: 2432 QTLEIQRQQSDHDA--ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489
Query: 580 ALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEE--KLKQLEEE----CRQKEAERVSLE 633
AL+ + IE + Q +E K +QL EE +Q E ER L
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 634 LELTEVKESLKKALAG 649
+ E + +A G
Sbjct: 2550 ASMEEARRRQHEAEEG 2565
Score = 32.0 bits (71), Expect = 2.1
Identities = 26/91 (28%), Positives = 47/91 (51%), Gaps = 9/91 (9%)
Query: 562 ADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEE 621
A A++L+ +++ ++ E R RL +E + + E RK +E+L+QLE++
Sbjct: 2525 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK-----QEELQQLEQQ 2579
Query: 622 CRQKE----AERVSLELELTEVKESLKKALA 648
RQ+E E L +L ++E + ALA
Sbjct: 2580 RRQQEELLAEENQRLREQLQLLEEQHRAALA 2610
Score = 30.8 bits (68), Expect = 4.7
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 4/89 (4%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILE--EKLKQL 618
+A A +Q KE+EL + + ++ L QLR E + R A E + QA E + +Q+
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Query: 619 EEECRQKEA--ERVSLELELTEVKESLKK 645
EE R K++ E+ + E L+K
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Score = 30.0 bits (66), Expect = 8.0
Identities = 18/82 (21%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 268 HKAELEKKLSSERPSSDGEGVVENGITTCNGKEQVKRKKSSKSE---AKGTVSKVTGKKI 324
HKA++E++L+ R +SD E + G+ ++ +++++ + E K + K K
Sbjct: 1887 HKADIEERLAQLRKASDSELERQKGLV----EDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 325 TKIISLGKKKPSTDEQTSSAEE 346
+ LG+ + + ++ S E+
Sbjct: 1943 ELELELGRIRSNAEDTLRSKEQ 1964
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/110 (25%), Positives = 53/110 (48%), Gaps = 12/110 (10%)
Query: 551 AQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRK------------ERKDLRAA 598
A+ + K E +A+R EE+ ++++E L + R+ E++ +R
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1687
Query: 599 IEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALA 648
E G + + +LEE+L +L+ E +R LE EL +V+ ++ LA
Sbjct: 1688 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1737
Score = 36.6 bits (83), Expect = 0.085
Identities = 30/108 (27%), Positives = 54/108 (50%), Gaps = 11/108 (10%)
Query: 537 ADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTK-EEELLKRKEALRNRLAQLRKERKDL 595
A+ A +++ A + K + E +AK LQ + +EE+++R+EA + Q R +++L
Sbjct: 1331 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1390
Query: 596 R-----AAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTE 638
+ + E+ A + E ++EEE R V L+LE TE
Sbjct: 1391 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV-----VRLQLEATE 1433
Score = 33.9 bits (76), Expect = 0.55
Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 6/91 (6%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRK----ERKDLRAAIEVNAGRKPQAILEEKLK 616
E +A + + EE+ + K + RLAQLRK E + + +E ++ Q +EE++
Sbjct: 1839 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ--VEEEIL 1896
Query: 617 QLEEECRQKEAERVSLELELTEVKESLKKAL 647
L+ + A + LELEL ++ + + L
Sbjct: 1897 ALKASFEKAAAGKAELELELGRIRSNAEDTL 1927
Score = 32.3 bits (72), Expect = 1.6
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 16/136 (11%)
Query: 528 KTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEE--------LLKRKE 579
+TL Q +++D A +R A+ + K +++ +AK LQ K EE LL+ +
Sbjct: 2400 QTLEIQRQQSDHDA--ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2457
Query: 580 ALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEE--KLKQLEEE----CRQKEAERVSLE 633
AL+ + IE + Q +E K +QL EE +Q E ER L
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517
Query: 634 LELTEVKESLKKALAG 649
+ E + +A G
Sbjct: 2518 ASMEEARRRQHEAEEG 2533
Score = 32.0 bits (71), Expect = 2.1
Identities = 26/91 (28%), Positives = 47/91 (51%), Gaps = 9/91 (9%)
Query: 562 ADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEE 621
A A++L+ +++ ++ E R RL +E + + E RK +E+L+QLE++
Sbjct: 2493 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK-----QEELQQLEQQ 2547
Query: 622 CRQKE----AERVSLELELTEVKESLKKALA 648
RQ+E E L +L ++E + ALA
Sbjct: 2548 RRQQEELLAEENQRLREQLQLLEEQHRAALA 2578
Score = 30.8 bits (68), Expect = 4.7
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 4/89 (4%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILE--EKLKQL 618
+A A +Q KE+EL + + ++ L QLR E + R A E + QA E + +Q+
Sbjct: 2020 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2079
Query: 619 EEECRQKEA--ERVSLELELTEVKESLKK 645
EE R K++ E+ + E L+K
Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLRK 2108
Score = 30.0 bits (66), Expect = 8.0
Identities = 18/82 (21%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 268 HKAELEKKLSSERPSSDGEGVVENGITTCNGKEQVKRKKSSKSE---AKGTVSKVTGKKI 324
HKA++E++L+ R +SD E + G+ ++ +++++ + E K + K K
Sbjct: 1855 HKADIEERLAQLRKASDSELERQKGLV----EDTLRQRRQVEEEILALKASFEKAAAGKA 1910
Query: 325 TKIISLGKKKPSTDEQTSSAEE 346
+ LG+ + + ++ S E+
Sbjct: 1911 ELELELGRIRSNAEDTLRSKEQ 1932
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/110 (25%), Positives = 53/110 (48%), Gaps = 12/110 (10%)
Query: 551 AQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRK------------ERKDLRAA 598
A+ + K E +A+R EE+ ++++E L + R+ E++ +R
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1856
Query: 599 IEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALA 648
E G + + +LEE+L +L+ E +R LE EL +V+ ++ LA
Sbjct: 1857 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1906
Score = 36.6 bits (83), Expect = 0.085
Identities = 30/108 (27%), Positives = 54/108 (50%), Gaps = 11/108 (10%)
Query: 537 ADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTK-EEELLKRKEALRNRLAQLRKERKDL 595
A+ A +++ A + K + E +AK LQ + +EE+++R+EA + Q R +++L
Sbjct: 1500 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1559
Query: 596 R-----AAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTE 638
+ + E+ A + E ++EEE R V L+LE TE
Sbjct: 1560 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV-----VRLQLEATE 1602
Score = 33.9 bits (76), Expect = 0.55
Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 6/91 (6%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRK----ERKDLRAAIEVNAGRKPQAILEEKLK 616
E +A + + EE+ + K + RLAQLRK E + + +E ++ Q +EE++
Sbjct: 2008 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ--VEEEIL 2065
Query: 617 QLEEECRQKEAERVSLELELTEVKESLKKAL 647
L+ + A + LELEL ++ + + L
Sbjct: 2066 ALKASFEKAAAGKAELELELGRIRSNAEDTL 2096
Score = 32.3 bits (72), Expect = 1.6
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 16/136 (11%)
Query: 528 KTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEE--------LLKRKE 579
+TL Q +++D A +R A+ + K +++ +AK LQ K EE LL+ +
Sbjct: 2569 QTLEIQRQQSDHDA--ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2626
Query: 580 ALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEE--KLKQLEEE----CRQKEAERVSLE 633
AL+ + IE + Q +E K +QL EE +Q E ER L
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686
Query: 634 LELTEVKESLKKALAG 649
+ E + +A G
Sbjct: 2687 ASMEEARRRQHEAEEG 2702
Score = 32.0 bits (71), Expect = 2.1
Identities = 26/91 (28%), Positives = 47/91 (51%), Gaps = 9/91 (9%)
Query: 562 ADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEE 621
A A++L+ +++ ++ E R RL +E + + E RK +E+L+QLE++
Sbjct: 2662 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK-----QEELQQLEQQ 2716
Query: 622 CRQKE----AERVSLELELTEVKESLKKALA 648
RQ+E E L +L ++E + ALA
Sbjct: 2717 RRQQEELLAEENQRLREQLQLLEEQHRAALA 2747
Score = 30.8 bits (68), Expect = 4.7
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 4/89 (4%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILE--EKLKQL 618
+A A +Q KE+EL + + ++ L QLR E + R A E + QA E + +Q+
Sbjct: 2189 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2248
Query: 619 EEECRQKEA--ERVSLELELTEVKESLKK 645
EE R K++ E+ + E L+K
Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRK 2277
Score = 30.0 bits (66), Expect = 8.0
Identities = 18/82 (21%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 268 HKAELEKKLSSERPSSDGEGVVENGITTCNGKEQVKRKKSSKSE---AKGTVSKVTGKKI 324
HKA++E++L+ R +SD E + G+ ++ +++++ + E K + K K
Sbjct: 2024 HKADIEERLAQLRKASDSELERQKGLV----EDTLRQRRQVEEEILALKASFEKAAAGKA 2079
Query: 325 TKIISLGKKKPSTDEQTSSAEE 346
+ LG+ + + ++ S E+
Sbjct: 2080 ELELELGRIRSNAEDTLRSKEQ 2101
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/110 (25%), Positives = 53/110 (48%), Gaps = 12/110 (10%)
Query: 551 AQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRK------------ERKDLRAA 598
A+ + K E +A+R EE+ ++++E L + R+ E++ +R
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1697
Query: 599 IEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALA 648
E G + + +LEE+L +L+ E +R LE EL +V+ ++ LA
Sbjct: 1698 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1747
Score = 36.6 bits (83), Expect = 0.085
Identities = 30/108 (27%), Positives = 54/108 (50%), Gaps = 11/108 (10%)
Query: 537 ADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTK-EEELLKRKEALRNRLAQLRKERKDL 595
A+ A +++ A + K + E +AK LQ + +EE+++R+EA + Q R +++L
Sbjct: 1341 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1400
Query: 596 R-----AAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTE 638
+ + E+ A + E ++EEE R V L+LE TE
Sbjct: 1401 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV-----VRLQLEATE 1443
Score = 33.9 bits (76), Expect = 0.55
Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 6/91 (6%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRK----ERKDLRAAIEVNAGRKPQAILEEKLK 616
E +A + + EE+ + K + RLAQLRK E + + +E ++ Q +EE++
Sbjct: 1849 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ--VEEEIL 1906
Query: 617 QLEEECRQKEAERVSLELELTEVKESLKKAL 647
L+ + A + LELEL ++ + + L
Sbjct: 1907 ALKASFEKAAAGKAELELELGRIRSNAEDTL 1937
Score = 32.3 bits (72), Expect = 1.6
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 16/136 (11%)
Query: 528 KTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEE--------LLKRKE 579
+TL Q +++D A +R A+ + K +++ +AK LQ K EE LL+ +
Sbjct: 2410 QTLEIQRQQSDHDA--ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2467
Query: 580 ALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEE--KLKQLEEE----CRQKEAERVSLE 633
AL+ + IE + Q +E K +QL EE +Q E ER L
Sbjct: 2468 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527
Query: 634 LELTEVKESLKKALAG 649
+ E + +A G
Sbjct: 2528 ASMEEARRRQHEAEEG 2543
Score = 32.0 bits (71), Expect = 2.1
Identities = 26/91 (28%), Positives = 47/91 (51%), Gaps = 9/91 (9%)
Query: 562 ADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEE 621
A A++L+ +++ ++ E R RL +E + + E RK +E+L+QLE++
Sbjct: 2503 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK-----QEELQQLEQQ 2557
Query: 622 CRQKE----AERVSLELELTEVKESLKKALA 648
RQ+E E L +L ++E + ALA
Sbjct: 2558 RRQQEELLAEENQRLREQLQLLEEQHRAALA 2588
Score = 30.8 bits (68), Expect = 4.7
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 4/89 (4%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILE--EKLKQL 618
+A A +Q KE+EL + + ++ L QLR E + R A E + QA E + +Q+
Sbjct: 2030 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2089
Query: 619 EEECRQKEA--ERVSLELELTEVKESLKK 645
EE R K++ E+ + E L+K
Sbjct: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRK 2118
Score = 30.0 bits (66), Expect = 8.0
Identities = 18/82 (21%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 268 HKAELEKKLSSERPSSDGEGVVENGITTCNGKEQVKRKKSSKSE---AKGTVSKVTGKKI 324
HKA++E++L+ R +SD E + G+ ++ +++++ + E K + K K
Sbjct: 1865 HKADIEERLAQLRKASDSELERQKGLV----EDTLRQRRQVEEEILALKASFEKAAAGKA 1920
Query: 325 TKIISLGKKKPSTDEQTSSAEE 346
+ LG+ + + ++ S E+
Sbjct: 1921 ELELELGRIRSNAEDTLRSKEQ 1942
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/110 (25%), Positives = 53/110 (48%), Gaps = 12/110 (10%)
Query: 551 AQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRK------------ERKDLRAA 598
A+ + K E +A+R EE+ ++++E L + R+ E++ +R
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1705
Query: 599 IEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALA 648
E G + + +LEE+L +L+ E +R LE EL +V+ ++ LA
Sbjct: 1706 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1755
Score = 36.6 bits (83), Expect = 0.085
Identities = 30/108 (27%), Positives = 54/108 (50%), Gaps = 11/108 (10%)
Query: 537 ADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTK-EEELLKRKEALRNRLAQLRKERKDL 595
A+ A +++ A + K + E +AK LQ + +EE+++R+EA + Q R +++L
Sbjct: 1349 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1408
Query: 596 R-----AAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTE 638
+ + E+ A + E ++EEE R V L+LE TE
Sbjct: 1409 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV-----VRLQLEATE 1451
Score = 33.9 bits (76), Expect = 0.55
Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 6/91 (6%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRK----ERKDLRAAIEVNAGRKPQAILEEKLK 616
E +A + + EE+ + K + RLAQLRK E + + +E ++ Q +EE++
Sbjct: 1857 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ--VEEEIL 1914
Query: 617 QLEEECRQKEAERVSLELELTEVKESLKKAL 647
L+ + A + LELEL ++ + + L
Sbjct: 1915 ALKASFEKAAAGKAELELELGRIRSNAEDTL 1945
Score = 32.3 bits (72), Expect = 1.6
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 16/136 (11%)
Query: 528 KTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEE--------LLKRKE 579
+TL Q +++D A +R A+ + K +++ +AK LQ K EE LL+ +
Sbjct: 2418 QTLEIQRQQSDHDA--ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2475
Query: 580 ALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEE--KLKQLEEE----CRQKEAERVSLE 633
AL+ + IE + Q +E K +QL EE +Q E ER L
Sbjct: 2476 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2535
Query: 634 LELTEVKESLKKALAG 649
+ E + +A G
Sbjct: 2536 ASMEEARRRQHEAEEG 2551
Score = 32.0 bits (71), Expect = 2.1
Identities = 26/91 (28%), Positives = 47/91 (51%), Gaps = 9/91 (9%)
Query: 562 ADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEE 621
A A++L+ +++ ++ E R RL +E + + E RK +E+L+QLE++
Sbjct: 2511 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK-----QEELQQLEQQ 2565
Query: 622 CRQKE----AERVSLELELTEVKESLKKALA 648
RQ+E E L +L ++E + ALA
Sbjct: 2566 RRQQEELLAEENQRLREQLQLLEEQHRAALA 2596
Score = 30.8 bits (68), Expect = 4.7
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 4/89 (4%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILE--EKLKQL 618
+A A +Q KE+EL + + ++ L QLR E + R A E + QA E + +Q+
Sbjct: 2038 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2097
Query: 619 EEECRQKEA--ERVSLELELTEVKESLKK 645
EE R K++ E+ + E L+K
Sbjct: 2098 EEAERLKQSAEEQAQARAQAQAAAEKLRK 2126
Score = 30.0 bits (66), Expect = 8.0
Identities = 18/82 (21%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 268 HKAELEKKLSSERPSSDGEGVVENGITTCNGKEQVKRKKSSKSE---AKGTVSKVTGKKI 324
HKA++E++L+ R +SD E + G+ ++ +++++ + E K + K K
Sbjct: 1873 HKADIEERLAQLRKASDSELERQKGLV----EDTLRQRRQVEEEILALKASFEKAAAGKA 1928
Query: 325 TKIISLGKKKPSTDEQTSSAEE 346
+ LG+ + + ++ S E+
Sbjct: 1929 ELELELGRIRSNAEDTLRSKEQ 1950
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/110 (25%), Positives = 53/110 (48%), Gaps = 12/110 (10%)
Query: 551 AQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRK------------ERKDLRAA 598
A+ + K E +A+R EE+ ++++E L + R+ E++ +R
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1746
Query: 599 IEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALA 648
E G + + +LEE+L +L+ E +R LE EL +V+ ++ LA
Sbjct: 1747 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1796
Score = 36.6 bits (83), Expect = 0.085
Identities = 30/108 (27%), Positives = 54/108 (50%), Gaps = 11/108 (10%)
Query: 537 ADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTK-EEELLKRKEALRNRLAQLRKERKDL 595
A+ A +++ A + K + E +AK LQ + +EE+++R+EA + Q R +++L
Sbjct: 1390 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1449
Query: 596 R-----AAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTE 638
+ + E+ A + E ++EEE R V L+LE TE
Sbjct: 1450 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV-----VRLQLEATE 1492
Score = 33.9 bits (76), Expect = 0.55
Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 6/91 (6%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRK----ERKDLRAAIEVNAGRKPQAILEEKLK 616
E +A + + EE+ + K + RLAQLRK E + + +E ++ Q +EE++
Sbjct: 1898 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ--VEEEIL 1955
Query: 617 QLEEECRQKEAERVSLELELTEVKESLKKAL 647
L+ + A + LELEL ++ + + L
Sbjct: 1956 ALKASFEKAAAGKAELELELGRIRSNAEDTL 1986
Score = 32.3 bits (72), Expect = 1.6
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 16/136 (11%)
Query: 528 KTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEE--------LLKRKE 579
+TL Q +++D A +R A+ + K +++ +AK LQ K EE LL+ +
Sbjct: 2459 QTLEIQRQQSDHDA--ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2516
Query: 580 ALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEE--KLKQLEEE----CRQKEAERVSLE 633
AL+ + IE + Q +E K +QL EE +Q E ER L
Sbjct: 2517 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2576
Query: 634 LELTEVKESLKKALAG 649
+ E + +A G
Sbjct: 2577 ASMEEARRRQHEAEEG 2592
Score = 32.0 bits (71), Expect = 2.1
Identities = 26/91 (28%), Positives = 47/91 (51%), Gaps = 9/91 (9%)
Query: 562 ADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEE 621
A A++L+ +++ ++ E R RL +E + + E RK +E+L+QLE++
Sbjct: 2552 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK-----QEELQQLEQQ 2606
Query: 622 CRQKE----AERVSLELELTEVKESLKKALA 648
RQ+E E L +L ++E + ALA
Sbjct: 2607 RRQQEELLAEENQRLREQLQLLEEQHRAALA 2637
Score = 30.8 bits (68), Expect = 4.7
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 4/89 (4%)
Query: 561 EADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILE--EKLKQL 618
+A A +Q KE+EL + + ++ L QLR E + R A E + QA E + +Q+
Sbjct: 2079 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2138
Query: 619 EEECRQKEA--ERVSLELELTEVKESLKK 645
EE R K++ E+ + E L+K
Sbjct: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRK 2167
Score = 30.0 bits (66), Expect = 8.0
Identities = 18/82 (21%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 268 HKAELEKKLSSERPSSDGEGVVENGITTCNGKEQVKRKKSSKSE---AKGTVSKVTGKKI 324
HKA++E++L+ R +SD E + G+ ++ +++++ + E K + K K
Sbjct: 1914 HKADIEERLAQLRKASDSELERQKGLV----EDTLRQRRQVEEEILALKASFEKAAAGKA 1969
Query: 325 TKIISLGKKKPSTDEQTSSAEE 346
+ LG+ + + ++ S E+
Sbjct: 1970 ELELELGRIRSNAEDTLRSKEQ 1991
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.368
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,376,140
Number of Sequences: 37866
Number of extensions: 1677559
Number of successful extensions: 14545
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 201
Number of HSP's successfully gapped in prelim test: 741
Number of HSP's that attempted gapping in prelim test: 10615
Number of HSP's gapped (non-prelim): 4084
length of query: 730
length of database: 18,247,518
effective HSP length: 110
effective length of query: 620
effective length of database: 14,082,258
effective search space: 8730999960
effective search space used: 8730999960
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.