Search of human proteins with 40807363

Search of human proteins with 40807363

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
         (309 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]          617   e-177
gi|223646115 short chain dehydrogenase/reductase family 16C, mem...   352   2e-97
gi|25282469 retinol dehydrogenase 10 [Homo sapiens]                   265   5e-71
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]        238   7e-63
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...   232   3e-61
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ...   189   3e-48
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B...   183   1e-46
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    88   1e-17
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]     86   5e-17
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    79   7e-15
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]     78   9e-15
gi|40254992 carbonic reductase 4 [Homo sapiens]                        78   1e-14
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    75   7e-14
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          74   2e-13
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    71   1e-12
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      70   2e-12
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]       70   2e-12
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]           70   3e-12
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...    70   3e-12
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...    69   4e-12
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom...    67   3e-11
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]    64   2e-10
gi|22507405 short chain dehydrogenase/reductase family 9C, membe...    64   2e-10
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                   63   3e-10
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]    62   5e-10
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]         62   8e-10
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...    60   2e-09
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...    60   2e-09
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]         60   2e-09
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform...    60   3e-09

>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score =  617 bits (1592), Expect = e-177
 Identities = 309/309 (100%), Positives = 309/309 (100%)

Query: 1   MSFNLQSSKKLFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQF 60
           MSFNLQSSKKLFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQF
Sbjct: 1   MSFNLQSSKKLFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQF 60

Query: 61  ARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVS 120
           ARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVS
Sbjct: 61  ARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVS 120

Query: 121 ILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAG 180
           ILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAG
Sbjct: 121 ILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAG 180

Query: 181 LSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPS 240
           LSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPS
Sbjct: 181 LSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPS 240

Query: 241 LLPILEPKYAVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLIADYLGILHAMD 300
           LLPILEPKYAVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLIADYLGILHAMD
Sbjct: 241 LLPILEPKYAVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLIADYLGILHAMD 300

Query: 301 GFVDQKKKL 309
           GFVDQKKKL
Sbjct: 301 GFVDQKKKL 309


>gi|223646115 short chain dehydrogenase/reductase family 16C, member
           6 [Homo sapiens]
          Length = 323

 Score =  352 bits (903), Expect = 2e-97
 Identities = 173/302 (57%), Positives = 223/302 (73%), Gaps = 7/302 (2%)

Query: 13  IFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDI 72
           + LGK  +  LE++++ ++PK +KNVAGEIVL TGAGSGLGR LA+ FAR G++LVLWD+
Sbjct: 9   VLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDV 68

Query: 73  NKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGK 132
           N+EGN ETC++A+E G  +V  YTCDCS ++ VYRVADQV+KE GDV+IL+NNA +VTGK
Sbjct: 69  NQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGK 128

Query: 133 KFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLAD--- 189
            FLD PD ++EKSF VN   H WT KAFLPA+I  +HGHLVCISS AG+ G+NGL+D   
Sbjct: 129 PFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYF 188

Query: 190 ----YCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPSLLPIL 245
               Y ASKFAAFGFAES+F E  + K+  +K+TIVCP FI TGMFEGCT+  P LLPIL
Sbjct: 189 VSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPIL 248

Query: 246 EPKYAVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLIADYLGILHAMDGFVDQ 305
           E +Y  +KI+ AIL+E++YL +PK  Y  + LK  +  K  +   +YLG+   M  F  +
Sbjct: 249 EQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDTCMASFKGR 308

Query: 306 KK 307
           KK
Sbjct: 309 KK 310


>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
          Length = 341

 Score =  265 bits (676), Expect = 5e-71
 Identities = 141/325 (43%), Positives = 201/325 (61%), Gaps = 26/325 (8%)

Query: 10  KLFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVL 69
           + F+   K L++ + A    L+    K+VAG++ LITGAGSGLGRL AL+FAR  ++LVL
Sbjct: 6   EFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVL 65

Query: 70  WDINKEGNEETCKMAR--------------EAGA----------TRVHAYTCDCSQKEGV 105
           WDIN + NEET  M R              +AG            +V  YTCD  ++E V
Sbjct: 66  WDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENV 125

Query: 106 YRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMI 165
           Y  A++V+KEVG+VS+L+NNAG+V+G   L+CPDEL+E++  VN  AH WT KAFLP M+
Sbjct: 126 YLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTML 185

Query: 166 ANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFF 225
             +HGH+V ++SS GL    G+ DYCASKF   GF ES+  E    ++ GIKTT+VCP+ 
Sbjct: 186 EINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYL 245

Query: 226 IKTGMFEGC--TTGCPSLLPILEPKYAVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPL 283
           + TGMF GC         LP L+P Y V++ ++AIL ++  +  P+L+Y + F+KS LP 
Sbjct: 246 VDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILPF 305

Query: 284 KTGLLIADYLGILHAMDGFVDQKKK 308
           +  + +  +LG    M  F+ Q+K+
Sbjct: 306 EAVVCMYRFLGADKCMYPFIAQRKQ 330


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score =  238 bits (606), Expect = 7e-63
 Identities = 124/260 (47%), Positives = 169/260 (65%), Gaps = 4/260 (1%)

Query: 23  LEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCK 82
           LE+ +   +PK RK+V GEIVLITGAG G+GRL A +FA+L S LVLWDINK G EET  
Sbjct: 19  LESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAA 78

Query: 83  MAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELM 142
             +  GA +VH +  DCS +E +Y  A +VK E+GDVSIL+NNAG+V         D  +
Sbjct: 79  KCKGLGA-KVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQI 137

Query: 143 EKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAE 202
           EK+F+VN  AH WT KAFLPAM  N+HGH+V ++S+AG   V  L  YC+SKFAA GF +
Sbjct: 138 EKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHK 197

Query: 203 SVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPSLLPILEPKYAVEKIVEAILQEK 262
           ++  E    +  G+KTT +CP F+ TG  +  +T   SL P LEP+  V +++  IL E+
Sbjct: 198 TLTDELAALQITGVKTTCLCPNFVNTGFIKNPST---SLGPTLEPEEVVNRLMHGILTEQ 254

Query: 263 MYLYMPKLLYFMMFLKSFLP 282
             +++P  + F+  L+  LP
Sbjct: 255 KMIFIPSSIAFLTTLERILP 274


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score =  232 bits (592), Expect = 3e-61
 Identities = 119/280 (42%), Positives = 172/280 (61%), Gaps = 4/280 (1%)

Query: 10  KLFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVL 69
           ++ + L   ++S LE+++   +P+ RK+VAGEIVLITGAG G+GR    +FA+  S+LVL
Sbjct: 6   EILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVL 65

Query: 70  WDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIV 129
           WDINK G EET    R+ G T  HAY  DCS +E +YR  +QVKKEVGDV+I++NNAG V
Sbjct: 66  WDINKRGVEETAAECRKLGVT-AHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTV 124

Query: 130 TGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLAD 189
                L   DE + K+F+VN   H W  KA LP+M+  +HGH+V ++S  G  G+  L  
Sbjct: 125 YPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIP 184

Query: 190 YCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPSLLPILEPKY 249
           YC+SKFAA GF   +  E     + GIKT+ +CP F+ TG  +  +T    L P+LE   
Sbjct: 185 YCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPST---RLWPVLETDE 241

Query: 250 AVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLI 289
            V  +++ IL  K  +++P  +   + L+ FLP +   ++
Sbjct: 242 VVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAIL 281


>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
           sapiens]
          Length = 302

 Score =  189 bits (479), Expect = 3e-48
 Identities = 106/293 (36%), Positives = 167/293 (56%), Gaps = 4/293 (1%)

Query: 11  LFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGS-VLVL 69
           L +F  + ++ +++A +  +LP   ++++ E VLITG G G+GR LA +FA  G+  +VL
Sbjct: 9   LVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVL 68

Query: 70  WDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIV 129
           W   ++  +ET +  R+ G T  H + CD   +E VY+ A  V+++VGD++IL+NNA +V
Sbjct: 69  WGRTEKCLKETTEEIRQMG-TECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVV 127

Query: 130 TGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLAD 189
            GK  +D  D+ + KS  +N     WT KAFLP M+   +GH+VC++S   LS + G  D
Sbjct: 128 HGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAID 187

Query: 190 YCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPSLLPILEPKY 249
           YC SK +AF F ES+ +   +    G+  T V PF   T MF+G     P+L P L+P+ 
Sbjct: 188 YCTSKASAFAFMESLTLG--LLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPET 245

Query: 250 AVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLIADYLGILHAMDGF 302
              + VEA+   +  L +P  ++ ++ LKS LP      I  + G    M+ F
Sbjct: 246 VARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTF 298


>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
           [Homo sapiens]
          Length = 264

 Score =  183 bits (465), Expect = 1e-46
 Identities = 102/280 (36%), Positives = 151/280 (53%), Gaps = 40/280 (14%)

Query: 10  KLFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVL 69
           ++ + L   ++S LE+++   +P+ RK+VAGEIVLITGAG G+GR    +FA+  S+LVL
Sbjct: 6   EILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVL 65

Query: 70  WDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIV 129
           WDINK                                     VKKEVGDV+I++NNAG V
Sbjct: 66  WDINK-------------------------------------VKKEVGDVTIVVNNAGTV 88

Query: 130 TGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLAD 189
                L   DE + K+F+VN   H W  KA LP+M+  +HGH+V ++S  G  G+  L  
Sbjct: 89  YPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIP 148

Query: 190 YCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPSLLPILEPKY 249
           YC+SKFAA GF   +  E     + GIKT+ +CP F+ TG  +  +T    L P+LE   
Sbjct: 149 YCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPST---RLWPVLETDE 205

Query: 250 AVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLI 289
            V  +++ IL  K  +++P  +   + L+ FLP +   ++
Sbjct: 206 VVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAIL 245


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 70/255 (27%), Positives = 119/255 (46%), Gaps = 17/255 (6%)

Query: 42  IVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAY-----T 96
           +V+ITGA SGLG+  A  F   G+ LVL   N    EE  +    + AT+V  +     T
Sbjct: 54  VVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVT 113

Query: 97  CDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWT 156
            D +    +   A ++ +  G V IL+NNAGI      +D   ++ ++  + N+   +  
Sbjct: 114 FDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVAL 173

Query: 157 YKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGI 216
            KA LP+MI    GH+V ISS  G   +   + Y ASK A   F + +  E    +Q  I
Sbjct: 174 TKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAE---MEQYEI 230

Query: 217 KTTIVCPFFIKTGMFEGCTTGCPSLLPILE--------PKYAVEKIVEAILQEKMYLYMP 268
           + T++ P +I T +     T   S   +++        P    + ++ A+ ++K  + + 
Sbjct: 231 EVTVISPGYIHTNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILA 290

Query: 269 KLL-YFMMFLKSFLP 282
            LL    ++L++  P
Sbjct: 291 DLLPSLAVYLRTLAP 305


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score = 85.5 bits (210), Expect = 5e-17
 Identities = 57/190 (30%), Positives = 97/190 (51%), Gaps = 14/190 (7%)

Query: 40  GEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDC 99
           G+++++T A  G+G+  AL FAR G+ ++  DIN+   +E  K         +     D 
Sbjct: 6   GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPG------IQTRVLDV 59

Query: 100 SQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKA 159
           ++K+ +    DQ   EV  + +L N AG V     LDC ++  + S ++N ++     KA
Sbjct: 60  TKKKQI----DQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKA 115

Query: 160 FLPAMIANDHGHLVCISS-SAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKT 218
           FLP M+A   G+++ +SS ++ + GV     Y  +K A  G  +SV  +     Q+GI+ 
Sbjct: 116 FLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFI---QQGIRC 172

Query: 219 TIVCPFFIKT 228
             VCP  + T
Sbjct: 173 NCVCPGTVDT 182


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 78.6 bits (192), Expect = 7e-15
 Identities = 61/209 (29%), Positives = 99/209 (47%), Gaps = 9/209 (4%)

Query: 20  FSLLEAMIFALL-PKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNE 78
           F LL  M+  L+ PKP   + G  V++TG  SG+G+ +A++  + G+ + L   N++   
Sbjct: 12  FVLLLYMVSPLISPKPLA-LPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLL 70

Query: 79  ETCKMAREAGATRVHAYTC---DCSQKEG-VYRVADQVKKEVGDVSILINNAGIVTGKKF 134
           +  K              C   D SQ    V  V  Q ++++G V +L+N AG+    KF
Sbjct: 71  QAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKF 130

Query: 135 LDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASK 194
            D      E+   +N+   ++  +A +  M     G +V +SS AG  G+ G   Y ASK
Sbjct: 131 EDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASK 190

Query: 195 FAAFGFAESVFVETFVQKQKGIKTTIVCP 223
           FA  G AE++ +E    K   +  T+  P
Sbjct: 191 FAIRGLAEALQMEV---KPYNVYITVAYP 216


>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
          Length = 736

 Score = 78.2 bits (191), Expect = 9e-15
 Identities = 62/226 (27%), Positives = 102/226 (45%), Gaps = 21/226 (9%)

Query: 40  GEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKE---------GNEETCKMAREAGAT 90
           G +VL+TGAG+GLGR  AL FA  G+++V+ D+  +           ++  +  R  G  
Sbjct: 9   GRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGK 68

Query: 91  RVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNF 150
            V  Y    S +EG  +V        G + +++NNAGI+  + F    DE  +    V+ 
Sbjct: 69  AVANYD---SVEEGE-KVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHL 124

Query: 151 KAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFV 210
           +      +A    M    +G ++  SS++G+ G  G A+Y A+K    G A S+ +E   
Sbjct: 125 RGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIE--- 181

Query: 211 QKQKGIKTTIVCPFFIKTGMFEGCTTGCP-SLLPILEPKYAVEKIV 255
               G K+ I C             T  P  L+  L+P+Y    ++
Sbjct: 182 ----GRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVL 223


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 55/190 (28%), Positives = 90/190 (47%), Gaps = 7/190 (3%)

Query: 41  EIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCS 100
           ++  + G   G+GR +A   AR G  L +   N EG +     A + G   + A++CD +
Sbjct: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAA---AGDLGGDHL-AFSCDVA 58

Query: 101 QKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKAF 160
           ++  V    ++++K +G V+ L+N AGI      +    E M      N    + T KA 
Sbjct: 59  KEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAA 118

Query: 161 LPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTTI 220
           +  MI    G +V + S  GL G +G + Y ASK    GF+ ++  E     +K I+  +
Sbjct: 119 MRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEV---ARKKIRVNV 175

Query: 221 VCPFFIKTGM 230
           V P F+ T M
Sbjct: 176 VAPGFVHTDM 185


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 56/208 (26%), Positives = 90/208 (43%), Gaps = 5/208 (2%)

Query: 33  KPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATR- 91
           +P   +   +V +TGA SG+G  LA Q ++LG  LVL        E   +   E G  + 
Sbjct: 43  RPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKE 102

Query: 92  --VHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVN 149
             +     D +           V +E G + IL+NN G+      +D   ++  K  ++N
Sbjct: 103 KDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELN 162

Query: 150 FKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETF 209
           +   +   K  LP MI    G +V ++S  G+  V     YCASK A  GF     + T 
Sbjct: 163 YLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNG--LRTE 220

Query: 210 VQKQKGIKTTIVCPFFIKTGMFEGCTTG 237
           +    GI  + +CP  +++ + E    G
Sbjct: 221 LATYPGIIVSNICPGPVQSNIVENSLAG 248


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 64/175 (36%), Positives = 82/175 (46%), Gaps = 12/175 (6%)

Query: 39  AGEIVLITGAGSGLGRLLALQFA-----RLGSVLVLWDINKEGNEETCKMAREA-GATRV 92
           A   VLI+G  SG+G  LA+Q A     R   V  + D+ K+   E    A EA G T  
Sbjct: 4   APRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAA--AGEALGQTLT 61

Query: 93  HAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKA 152
            A    CS +     VA  +    G+V +L+NNAG+             M+  FD NF  
Sbjct: 62  VAQLDVCSDES----VAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFG 117

Query: 153 HLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVE 207
            +   KA LP M     GH+V ISS  GL GV     Y ASKFA  GF ES+ ++
Sbjct: 118 AVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQ 172


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 55/201 (27%), Positives = 91/201 (45%), Gaps = 15/201 (7%)

Query: 37  NVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMA--REAGATRVHA 94
           +V G++ L+TGA  G+GR  A      G+ + L D N E   + CK A   +    +   
Sbjct: 2   HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQ-CKAALDEQFEPQKTLF 60

Query: 95  YTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHL 154
             CD + ++ +     +V    G + IL+NNAG+   K +        EK+  +N  + +
Sbjct: 61  IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW--------EKTLQINLVSVI 112

Query: 155 -WTYKA--FLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQ 211
             TY    ++      + G ++ +SS AGL  V     YCASK    GF  S  +   + 
Sbjct: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLM 172

Query: 212 KQKGIKTTIVCPFFIKTGMFE 232
              G++   +CP F+ T + E
Sbjct: 173 -NSGVRLNAICPGFVNTAILE 192


>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 63/226 (27%), Positives = 102/226 (45%), Gaps = 3/226 (1%)

Query: 40  GEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDC 99
           G+ V++TGA  G+GR +A   A++G+ +V+   +KE  ++      E GA   H      
Sbjct: 34  GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTM 93

Query: 100 SQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKA 159
                  +   Q  K +G + +LI N    T           + KS +VNF +++    A
Sbjct: 94  EDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA 153

Query: 160 FLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTT 219
            LP M+   +G +V +SS AG      +A Y ASKFA  GF  S+  E  V +   +  T
Sbjct: 154 ALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSR-VNVSIT 211

Query: 220 IVCPFFIKTGMFEGCTTGCPSLLPILEPKYAVEKIV-EAILQEKMY 264
           +     I T       +G   +    + + A+E I   A+ QE++Y
Sbjct: 212 LCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVY 257


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 63/226 (27%), Positives = 102/226 (45%), Gaps = 3/226 (1%)

Query: 40  GEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDC 99
           G+ V++TGA  G+GR +A   A++G+ +V+   +KE  ++      E GA   H      
Sbjct: 34  GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTM 93

Query: 100 SQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKA 159
                  +   Q  K +G + +LI N    T           + KS +VNF +++    A
Sbjct: 94  EDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA 153

Query: 160 FLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTT 219
            LP M+   +G +V +SS AG      +A Y ASKFA  GF  S+  E  V +   +  T
Sbjct: 154 ALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSR-VNVSIT 211

Query: 220 IVCPFFIKTGMFEGCTTGCPSLLPILEPKYAVEKIV-EAILQEKMY 264
           +     I T       +G   +    + + A+E I   A+ QE++Y
Sbjct: 212 LCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVY 257


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 60/225 (26%), Positives = 104/225 (46%), Gaps = 23/225 (10%)

Query: 42  IVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKM-----AREAGATRVH-AY 95
           + L+TGAGSG+GR ++++ A  G+ +   D+++   +ET ++     ++E      H A+
Sbjct: 13  LALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAF 72

Query: 96  TCDCSQKEGVYRVADQVKKEVG-DVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHL 154
             D S+      + +QV+       S++++ AGI   +  L   ++  +K   VN K   
Sbjct: 73  QADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTF 132

Query: 155 WTYKAFLPAMIAND-HGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQ 213
              +A   A+++N   G ++ ISS  G  G  G  +Y ASK    G  ++   E     +
Sbjct: 133 LVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAAREL---GR 189

Query: 214 KGIKTTIVCPFFIKTGMFEGCTTGCPSLLPILEPKYAVEKIVEAI 258
            GI+   V P FI T M +              P+  V+KI E I
Sbjct: 190 HGIRCNSVLPGFIATPMTQKV------------PQKVVDKITEMI 222


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 62/215 (28%), Positives = 103/215 (47%), Gaps = 16/215 (7%)

Query: 19  LFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNE 78
           L +LL A+++ L  +     +   V ITG  SG GRLLALQ  + G  ++   +   G E
Sbjct: 7   LGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAE 66

Query: 79  ETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSI--LINN---AGIVTGKK 133
           +  ++A    ++R+H    D +  + V + A  V+  V +  +  L+NN   AGI+    
Sbjct: 67  DLQRVA----SSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTP 122

Query: 134 FLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCAS 193
           +L   D   ++  +VN    +    A LP ++    G ++ I+S  G    NG   YC S
Sbjct: 123 WLTRDD--FQRVLNVNTMGPIGVTLALLP-LLQQARGRVINITSVLGRLAANG-GGYCVS 178

Query: 194 KFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKT 228
           KF    F++S+  +       GI+ +IV P F +T
Sbjct: 179 KFGLEAFSDSLRRDV---AHFGIRVSIVEPGFFRT 210


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 51/195 (26%), Positives = 89/195 (45%), Gaps = 5/195 (2%)

Query: 35  RKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHA 94
           R  +A ++ L+T +  G+G  +A + A+ G+ +V+    K+ N +      +     V  
Sbjct: 27  RDPLANKVALVTASTDGIGFAIARRLAQDGAHVVV-SSRKQQNVDQAVATLQGEGLSVTG 85

Query: 95  YTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTG-KKFLDCPDELMEKSFDVNFKAH 153
             C   + E   R+     K  G + IL++NA +       +D  +E+ +K+ D+N KA 
Sbjct: 86  TVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAP 145

Query: 154 LWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQ 213
               KA +P M     G +V +SS A  S   G + Y  SK A  G  +++ +E      
Sbjct: 146 ALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIEL---AP 202

Query: 214 KGIKTTIVCPFFIKT 228
           + I+   + P  IKT
Sbjct: 203 RNIRVNCLAPGLIKT 217


>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
           sapiens]
          Length = 311

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 59/195 (30%), Positives = 88/195 (45%), Gaps = 7/195 (3%)

Query: 38  VAGEIVLITGAGSGLGRLLALQFARLGSVLVL----WDINKEGNEETCKMAREAGATRVH 93
           V  ++V+IT A SGLG+  A  F   G+ LVL    W+  +   +    +A  +      
Sbjct: 35  VQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPK 94

Query: 94  AYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAH 153
               D S    V  VA +V    G V ILINNA +           EL +K  D N+   
Sbjct: 95  LVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGP 154

Query: 154 LWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQ 213
           +   KA LP MI+   G +V +++  G  G+     Y ASK AA GF + +  E    ++
Sbjct: 155 ITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLRAEV---EE 211

Query: 214 KGIKTTIVCPFFIKT 228
             +  + V P FI++
Sbjct: 212 YDVVISTVSPTFIRS 226


>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
          Length = 312

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 49/195 (25%), Positives = 94/195 (48%), Gaps = 13/195 (6%)

Query: 40  GEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDC 99
           GE  ++TG+  G+G+  A + A+ G  +VL   +K+  ++     +E           D 
Sbjct: 50  GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDF 109

Query: 100 SQKEGVYRVADQVKKEVG--DVSILINNAGIVTG--KKFLDCPD--ELMEKSFDVNFKAH 153
           + ++    + D++K  +   ++ IL+NN G+     + FLD PD   +++K  ++N  + 
Sbjct: 110 ASED----IYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSV 165

Query: 154 LWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQ 213
               +  LP M+    G ++ ISS +G+  V  L  Y A+K     F++ +  E    + 
Sbjct: 166 CKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEE---YRS 222

Query: 214 KGIKTTIVCPFFIKT 228
           KG+    V P+F+ T
Sbjct: 223 KGVFVQSVLPYFVAT 237


>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
           [Homo sapiens]
          Length = 313

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 58/198 (29%), Positives = 95/198 (47%), Gaps = 14/198 (7%)

Query: 37  NVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYT 96
           N++ + V ITG  SG G LLA Q    G  ++     +EG++   K+ R+  + R+    
Sbjct: 22  NLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQ---KLQRDT-SYRLQTTL 77

Query: 97  CDCSQKEGVYRVADQVKKEVGDVSI--LINNAGI--VTGKKFLDCPDELMEKSFDVNFKA 152
            D ++ E +   A  V+ +VG+  +  L+NNAG+   +G       D+ + K  +VN   
Sbjct: 78  LDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFV-KVINVNLVG 136

Query: 153 HLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQK 212
            +      LP M+    G +V +SSS G   V G   YC SKF    F++S+  E +   
Sbjct: 137 LIEVTLHMLP-MVKRARGRVVNMSSSGGRVAVIG-GGYCVSKFGVEAFSDSIRRELY--- 191

Query: 213 QKGIKTTIVCPFFIKTGM 230
             G+K  I+ P   +T +
Sbjct: 192 YFGVKVCIIEPGNYRTAI 209


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 58/195 (29%), Positives = 90/195 (46%), Gaps = 20/195 (10%)

Query: 43  VLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQK 102
           V ITG  SG G+LLA Q    G  ++   + ++G E+     R   + R+   T D ++ 
Sbjct: 32  VFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQ----LRGQTSDRLETVTLDVTKT 87

Query: 103 EGVYRVADQVKKEVGDVSI--LINNAGIVTGKKFLDCPDELMEKS-----FDVNFKAHLW 155
           E V   A  VK+ V D  +  L+NNAGI         P+EL+ K       DVN    + 
Sbjct: 88  ESVAAAAQWVKECVRDKGLWGLVNNAGI----SLPTAPNELLTKQDFVTILDVNLLGVID 143

Query: 156 TYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKG 215
              + LP ++    G +V +SS  G   + G   YC SK+    F++S+  E       G
Sbjct: 144 VTLSLLP-LVRRARGRVVNVSSVMGRVSLFG-GGYCISKYGVEAFSDSLRREL---SYFG 198

Query: 216 IKTTIVCPFFIKTGM 230
           +K  ++ P + KT +
Sbjct: 199 VKVAMIEPGYFKTAV 213


>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
          Length = 317

 Score = 62.4 bits (150), Expect = 5e-10
 Identities = 56/193 (29%), Positives = 91/193 (47%), Gaps = 16/193 (8%)

Query: 43  VLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQK 102
           V ITG  SG G LLA Q    G  ++   + ++G E+     R   + R+   T D ++ 
Sbjct: 32  VFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQ----LRGQTSDRLETVTLDVTKM 87

Query: 103 EGVYRVADQVKKEVGDVSI--LINNAGI---VTGKKFLDCPDELMEKSFDVNFKAHLWTY 157
           E +      VK+ VGD  +  L+NNAGI   +T  ++L+  D +      VN    +   
Sbjct: 88  ESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSM--NMLKVNLIGVIQVT 145

Query: 158 KAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIK 217
            + LP ++    G +V +SS  G      +  YC SK+    F++ +  E    +  G+K
Sbjct: 146 LSMLP-LVRRARGRIVNVSSILGRVAF-FVGGYCVSKYGVEAFSDILRREI---QHFGVK 200

Query: 218 TTIVCPFFIKTGM 230
            +IV P + +TGM
Sbjct: 201 ISIVEPGYFRTGM 213


>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
          Length = 331

 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 52/188 (27%), Positives = 84/188 (44%), Gaps = 24/188 (12%)

Query: 35  RKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAR-EAGATRVH 93
           +  + G+ V++TGA +G+G+  AL+ AR G  ++L   + E  E   K  R E     V+
Sbjct: 33  KATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVN 92

Query: 94  AYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCP----DELMEKSFDVN 149
           A   D +  + +   A ++ +E   V ILINNAG+      + CP    ++  E  F VN
Sbjct: 93  ARHLDLASLKSIREFAAKIIEEEERVDILINNAGV------MRCPHWTTEDGFEMQFGVN 146

Query: 150 FKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSG-------------VNGLADYCASKFA 196
              H       L  + A+    ++ +SS A ++G              N  A YC SK A
Sbjct: 147 HLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLA 206

Query: 197 AFGFAESV 204
              F + +
Sbjct: 207 IVLFTKEL 214


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 59/226 (26%), Positives = 100/226 (44%), Gaps = 10/226 (4%)

Query: 35  RKNV-AGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVH 93
           RK V A  + ++TG+ SG+G  +A + AR G+ +V+    K+ N +      +     V 
Sbjct: 30  RKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVI-SSRKQQNVDRAMAKLQGEGLSVA 88

Query: 94  AYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGI--VTGKKFLDCPDELMEKSFDVNFK 151
              C   + E   ++  +  +  G V  L+ +AG+  + G   L   +++ +K   VN K
Sbjct: 89  GIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGST-LGTSEQIWDKILSVNVK 147

Query: 152 AHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQ 211
           +        LP M  N  G ++ +SS A  + V  L  Y  SK A  G   ++ +E    
Sbjct: 148 SPALLLSQLLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALEL--- 203

Query: 212 KQKGIKTTIVCPFFIKTGMFEGCTTGCPSLLPILEPKYAVEKIVEA 257
             K I+   V P  IKT  F     G  SL    +  + +++I E+
Sbjct: 204 APKDIRVNCVVPGIIKTD-FSKVFHGNESLWKNFKEHHQLQRIGES 248


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 44/174 (25%), Positives = 78/174 (44%), Gaps = 2/174 (1%)

Query: 35  RKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHA 94
           R  +  ++ L+T +  G+G  +A + A+  + +V+    K+ N +      +     V  
Sbjct: 27  RDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVV-SSRKQQNVDQAVATLQGEGLSVTG 85

Query: 95  YTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTG-KKFLDCPDELMEKSFDVNFKAH 153
             C   + E   R+     K  G + IL++NA +       +D  +E+ +K+ D+N KA 
Sbjct: 86  TVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAP 145

Query: 154 LWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVE 207
               KA +P M     G +V +SS A  S   G + Y  SK A  G   ++ +E
Sbjct: 146 ALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIE 199


>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
          Length = 418

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 48/184 (26%), Positives = 87/184 (47%), Gaps = 9/184 (4%)

Query: 38  VAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETC----KMAREAGATRVH 93
           +AG  V ITGA  G+G+ +AL+ A+ G+ +V+     + + +        A E  A    
Sbjct: 8   LAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAVGGK 67

Query: 94  AYTC--DCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFK 151
           A  C  D   ++ +    ++  K+ G + IL+NNA  ++    LD P + ++   +VN +
Sbjct: 68  ALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVNTR 127

Query: 152 AHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQ 211
                 KA +P +  +   H++ IS    L+ V     +CA   A +G   S++V    +
Sbjct: 128 GTYLASKACIPYLKKSKVAHILNISPPLNLNPV-WFKQHCAYTIAKYGM--SMYVLGMAE 184

Query: 212 KQKG 215
           + KG
Sbjct: 185 EFKG 188


>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
           [Homo sapiens]
          Length = 178

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 49/172 (28%), Positives = 78/172 (45%), Gaps = 14/172 (8%)

Query: 37  NVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMA--REAGATRVHA 94
           +V G++ L+TGA  G+GR  A      G+ + L D N E   + CK A   +    +   
Sbjct: 2   HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQ-CKAALDEQFEPQKTLF 60

Query: 95  YTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHL 154
             CD + ++ +     +V    G + IL+NNAG+   K +        EK+  +N  + +
Sbjct: 61  IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW--------EKTLQINLVSVI 112

Query: 155 -WTYKA--FLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAES 203
             TY    ++      + G ++ +SS AGL  V     YCASK    GF  S
Sbjct: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRS 164


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.140    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,391,340
Number of Sequences: 37866
Number of extensions: 423438
Number of successful extensions: 1249
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 1132
Number of HSP's gapped (non-prelim): 91
length of query: 309
length of database: 18,247,518
effective HSP length: 102
effective length of query: 207
effective length of database: 14,385,186
effective search space: 2977733502
effective search space used: 2977733502
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.