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Search of human proteins with 40806211
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
(431 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 906 0.0
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 906 0.0
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 758 0.0
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 685 0.0
gi|114520609 neural precursor cell expressed, developmentally do... 441 e-124
gi|114520607 neural precursor cell expressed, developmentally do... 441 e-124
gi|222352183 neural precursor cell expressed, developmentally do... 435 e-122
gi|21361472 neural precursor cell expressed, developmentally dow... 435 e-122
gi|222352094 neural precursor cell expressed, developmentally do... 435 e-122
gi|222352092 neural precursor cell expressed, developmentally do... 435 e-122
gi|222352090 neural precursor cell expressed, developmentally do... 435 e-122
gi|222352088 neural precursor cell expressed, developmentally do... 435 e-122
gi|222352086 neural precursor cell expressed, developmentally do... 435 e-122
gi|222352084 neural precursor cell expressed, developmentally do... 435 e-122
gi|222352082 neural precursor cell expressed, developmentally do... 435 e-122
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 432 e-121
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 430 e-120
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 430 e-120
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 363 e-100
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 360 2e-99
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 321 7e-88
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 279 3e-75
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 213 4e-55
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 213 4e-55
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 213 4e-55
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 203 2e-52
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 198 9e-51
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 179 4e-45
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 179 4e-45
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 178 7e-45
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 906 bits (2342), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKY 60
MIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKY
Sbjct: 1 MIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKY 60
Query: 61 HQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGI 120
HQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGI
Sbjct: 61 HQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGI 120
Query: 121 AREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHG 180
AREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHG
Sbjct: 121 AREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHG 180
Query: 181 KFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEIL 240
KFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEIL
Sbjct: 181 KFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEIL 240
Query: 241 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY 300
GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY
Sbjct: 241 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY 300
Query: 301 FDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVT 360
FDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVT
Sbjct: 301 FDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVT 360
Query: 361 GTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLY 420
GTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLY
Sbjct: 361 GTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLY 420
Query: 421 AIEETEGFGQE 431
AIEETEGFGQE
Sbjct: 421 AIEETEGFGQE 431
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 906 bits (2342), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKY 60
MIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKY
Sbjct: 440 MIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKY 499
Query: 61 HQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGI 120
HQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGI
Sbjct: 500 HQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGI 559
Query: 121 AREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHG 180
AREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHG
Sbjct: 560 AREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHG 619
Query: 181 KFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEIL 240
KFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEIL
Sbjct: 620 KFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEIL 679
Query: 241 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY 300
GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY
Sbjct: 680 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY 739
Query: 301 FDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVT 360
FDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVT
Sbjct: 740 FDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVT 799
Query: 361 GTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLY 420
GTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLY
Sbjct: 800 GTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLY 859
Query: 421 AIEETEGFGQE 431
AIEETEGFGQE
Sbjct: 860 AIEETEGFGQE 870
Score = 46.2 bits (108), Expect = 6e-05
Identities = 24/68 (35%), Positives = 34/68 (50%)
Query: 4 EPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQF 63
E LPPGWE + G Y+VDHNTRTTT++ P + +Q ++
Sbjct: 329 ERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQ 388
Query: 64 RFLCHSNA 71
RFL S++
Sbjct: 389 RFLYQSSS 396
Score = 45.1 bits (105), Expect = 1e-04
Identities = 21/40 (52%), Positives = 27/40 (67%), Gaps = 1/40 (2%)
Query: 6 ALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP-RPGFESGT 44
ALP GWE + G Y+VDHNT+TTT++ P PG+E T
Sbjct: 301 ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRT 340
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 758 bits (1958), Expect = 0.0
Identities = 349/428 (81%), Positives = 395/428 (92%)
Query: 4 EPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQF 63
E LP GWE++YT EGVRYFVDHNTRTTTFKDPR G S TK G AY+R FRWK F
Sbjct: 495 EEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHF 554
Query: 64 RFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIARE 123
R+LC SNALPSHVKI+VSRQTLFEDSFQQIM +KPYDLRRRLY+I RGEEGLDYGG+ARE
Sbjct: 555 RYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLARE 614
Query: 124 WFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFI 183
WFFLLSHEVLNPMYCLFEYAGKNNYCLQINPAS+INPDHL+YF FIGRFIAMAL+HGKFI
Sbjct: 615 WFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFI 674
Query: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
DTGF+LPFYKRML+K+ T+KDLESID EFYNS++WI++NN+EECGLE+YF DMEILGKV
Sbjct: 675 DTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKV 734
Query: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
T+H+LK GG +I VTEENK+EYI L+T+WRF+RGV+EQTKAFLDGFNEV PL+WL+YFDE
Sbjct: 735 TSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDE 794
Query: 304 KELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTC 363
KELE+MLCGMQE+D++DWQ++T+YRHYT+NSKQI WFWQ VKE DNE R+RLLQFVTGTC
Sbjct: 795 KELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTC 854
Query: 364 RLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIE 423
RLP+GGFAEL+GSNGPQKFCI+KVGK+TWLPRSHTCFNRLDLPPYKSYEQL+EKLL+AIE
Sbjct: 855 RLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIE 914
Query: 424 ETEGFGQE 431
ETEGFGQE
Sbjct: 915 ETEGFGQE 922
Score = 45.4 bits (106), Expect = 1e-04
Identities = 18/32 (56%), Positives = 23/32 (71%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 38
LP GWE + G Y+VDHNTRTTT++ P+P
Sbjct: 351 LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQP 382
Score = 42.4 bits (98), Expect = 8e-04
Identities = 20/36 (55%), Positives = 24/36 (66%), Gaps = 2/36 (5%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFES 42
LPPGWE + Y+VDHNTRTTT++ RP ES
Sbjct: 383 LPPGWERRVDDRRRVYYVDHNTRTTTWQ--RPTMES 416
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 685 bits (1767), Expect = 0.0
Identities = 315/430 (73%), Positives = 369/430 (85%), Gaps = 1/430 (0%)
Query: 2 IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYH 61
+ E LP GWEM++T +G+ YFVDHN RTTT+ DPR G +S G AY R F+ K
Sbjct: 434 LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTG-KSALDNGPQIAYVRDFKAKVQ 492
Query: 62 QFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIA 121
FRF C A+P H+KI+V+R+TLFEDSFQQIM+ P DLRRRL++I GEEGLDYGG+A
Sbjct: 493 YFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVA 552
Query: 122 REWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGK 181
REWFFLLSHEVLNPMYCLFEYAGK+NYCLQINPAS INPDHL YFRFIGRFIAMAL+HGK
Sbjct: 553 REWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGK 612
Query: 182 FIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILG 241
FIDTGF+LPFYKR+LNK LKDLESIDPEFYNS++W+KENN+EEC LE+YF D EILG
Sbjct: 613 FIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILG 672
Query: 242 KVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYF 301
++ +H+LK G +I VTEENKEEYI ++ +WR +RGVEEQT+AF +GFNE+ P ++L+YF
Sbjct: 673 EIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYF 732
Query: 302 DEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTG 361
D KELE++LCGMQEID++DWQ+ IYRHY + SKQI WFWQ VKE+DNEKR+RLLQFVTG
Sbjct: 733 DAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTG 792
Query: 362 TCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYA 421
TCRLPVGGFA+L+GSNGPQKFCI+KVGKE WLPRSHTCFNRLDLPPYKSYEQL+EKLL+A
Sbjct: 793 TCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFA 852
Query: 422 IEETEGFGQE 431
IEETEGFGQE
Sbjct: 853 IEETEGFGQE 862
Score = 41.6 bits (96), Expect = 0.001
Identities = 20/36 (55%), Positives = 25/36 (69%), Gaps = 2/36 (5%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFES 42
LPPGWE + + G Y+VDH TRTTT++ RP ES
Sbjct: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQ--RPTLES 352
Score = 38.9 bits (89), Expect = 0.009
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 2 IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 38
+ + LPPGWE + G Y+VDH + TT+ P P
Sbjct: 282 VTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEP 318
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 441 bits (1133), Expect = e-124
Identities = 219/426 (51%), Positives = 301/426 (70%), Gaps = 8/426 (1%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRF- 65
LPPGWE + ++G ++++HN + T ++DPR E+ G Y R ++ KY FR
Sbjct: 475 LPPGWEERTHTDGRIFYINHNIKRTQWEDPR--LENVAITGPAVPYSRDYKRKYEFFRRK 532
Query: 66 LCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
L N +P+ ++ + R T+ EDS+++IM +K D L+ RL+I GE+GLDYGG+AREW
Sbjct: 533 LKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREW 592
Query: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
FFL+S E+ NP Y LFEY+ +NY LQINP S + N DHL+YF+FIGR MA+YHGK +
Sbjct: 593 FFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLL 652
Query: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
D F PFYK ML+K TL D+ES+D E+YNS+ WI EN+ E L+L FI D E+ G+
Sbjct: 653 DGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE--LDLRFIIDEELFGQT 710
Query: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
HELK GG I VT +NK+EYI L+ WRF +++Q AF +GF E+ P + ++ FDE
Sbjct: 711 HQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDE 770
Query: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
ELEL++CG+ ++D++DW++ T Y++ Y+ N + IQWFW+ V MD+EKRIRLLQFVTGT
Sbjct: 771 NELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGT 830
Query: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
R+P+ GFAEL GSNGPQ F +++ G LPR+HTCFNRLDLPPY+S+E+L +KL AI
Sbjct: 831 SRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAI 890
Query: 423 EETEGF 428
E T+GF
Sbjct: 891 ENTQGF 896
Score = 44.7 bits (104), Expect = 2e-04
Identities = 18/30 (60%), Positives = 21/30 (70%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
LPPGWE K G Y+VDHN+RTTT+ P
Sbjct: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKP 379
Score = 39.3 bits (90), Expect = 0.007
Identities = 18/37 (48%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 3 QEPA-LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 38
QEP+ LPPGWE + G Y+V+H +R T +K P P
Sbjct: 188 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTP 224
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 441 bits (1133), Expect = e-124
Identities = 219/426 (51%), Positives = 301/426 (70%), Gaps = 8/426 (1%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRF- 65
LPPGWE + ++G ++++HN + T ++DPR E+ G Y R ++ KY FR
Sbjct: 822 LPPGWEERTHTDGRIFYINHNIKRTQWEDPR--LENVAITGPAVPYSRDYKRKYEFFRRK 879
Query: 66 LCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
L N +P+ ++ + R T+ EDS+++IM +K D L+ RL+I GE+GLDYGG+AREW
Sbjct: 880 LKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREW 939
Query: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
FFL+S E+ NP Y LFEY+ +NY LQINP S + N DHL+YF+FIGR MA+YHGK +
Sbjct: 940 FFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLL 999
Query: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
D F PFYK ML+K TL D+ES+D E+YNS+ WI EN+ E L+L FI D E+ G+
Sbjct: 1000 DGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE--LDLRFIIDEELFGQT 1057
Query: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
HELK GG I VT +NK+EYI L+ WRF +++Q AF +GF E+ P + ++ FDE
Sbjct: 1058 HQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDE 1117
Query: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
ELEL++CG+ ++D++DW++ T Y++ Y+ N + IQWFW+ V MD+EKRIRLLQFVTGT
Sbjct: 1118 NELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGT 1177
Query: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
R+P+ GFAEL GSNGPQ F +++ G LPR+HTCFNRLDLPPY+S+E+L +KL AI
Sbjct: 1178 SRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAI 1237
Query: 423 EETEGF 428
E T+GF
Sbjct: 1238 ENTQGF 1243
Score = 44.7 bits (104), Expect = 2e-04
Identities = 18/30 (60%), Positives = 21/30 (70%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
LPPGWE K G Y+VDHN+RTTT+ P
Sbjct: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKP 726
Score = 39.3 bits (90), Expect = 0.007
Identities = 18/37 (48%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 3 QEPA-LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 38
QEP+ LPPGWE + G Y+V+H +R T +K P P
Sbjct: 535 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTP 571
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 435 bits (1118), Expect = e-122
Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY FR
Sbjct: 429 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 486
Query: 67 CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREW
Sbjct: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546
Query: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
FFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK +
Sbjct: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606
Query: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+
Sbjct: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 664
Query: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
+LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE
Sbjct: 665 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 724
Query: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT
Sbjct: 725 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 784
Query: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+
Sbjct: 785 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844
Query: 423 EETEGF 428
E +GF
Sbjct: 845 ENAQGF 850
Score = 42.0 bits (97), Expect = 0.001
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59
P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A R FR +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
Query: 60 YH 61
H
Sbjct: 132 RH 133
Score = 40.8 bits (94), Expect = 0.002
Identities = 16/32 (50%), Positives = 22/32 (68%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
P LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 264 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 435 bits (1118), Expect = e-122
Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY FR
Sbjct: 530 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 587
Query: 67 CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREW
Sbjct: 588 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 647
Query: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
FFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK +
Sbjct: 648 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 707
Query: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+
Sbjct: 708 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 765
Query: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
+LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE
Sbjct: 766 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 825
Query: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT
Sbjct: 826 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 885
Query: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+
Sbjct: 886 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 945
Query: 423 EETEGF 428
E +GF
Sbjct: 946 ENAQGF 951
Score = 42.0 bits (97), Expect = 0.001
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59
P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A R FR +
Sbjct: 193 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 252
Query: 60 YH 61
H
Sbjct: 253 RH 254
Score = 40.8 bits (94), Expect = 0.002
Identities = 16/32 (50%), Positives = 22/32 (68%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
P LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 365 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 396
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 435 bits (1118), Expect = e-122
Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY FR
Sbjct: 409 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 466
Query: 67 CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREW
Sbjct: 467 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 526
Query: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
FFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK +
Sbjct: 527 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 586
Query: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+
Sbjct: 587 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 644
Query: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
+LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE
Sbjct: 645 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 704
Query: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT
Sbjct: 705 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 764
Query: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+
Sbjct: 765 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 824
Query: 423 EETEGF 428
E +GF
Sbjct: 825 ENAQGF 830
Score = 42.0 bits (97), Expect = 0.001
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59
P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A R FR +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
Query: 60 YH 61
H
Sbjct: 132 RH 133
Score = 40.8 bits (94), Expect = 0.002
Identities = 16/32 (50%), Positives = 22/32 (68%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
P LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 244 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 435 bits (1118), Expect = e-122
Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY FR
Sbjct: 409 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 466
Query: 67 CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREW
Sbjct: 467 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 526
Query: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
FFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK +
Sbjct: 527 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 586
Query: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+
Sbjct: 587 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 644
Query: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
+LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE
Sbjct: 645 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 704
Query: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT
Sbjct: 705 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 764
Query: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+
Sbjct: 765 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 824
Query: 423 EETEGF 428
E +GF
Sbjct: 825 ENAQGF 830
Score = 42.0 bits (97), Expect = 0.001
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59
P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A R FR +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
Query: 60 YH 61
H
Sbjct: 132 RH 133
Score = 40.8 bits (94), Expect = 0.002
Identities = 16/32 (50%), Positives = 22/32 (68%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
P LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 244 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 435 bits (1118), Expect = e-122
Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY FR
Sbjct: 522 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 579
Query: 67 CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREW
Sbjct: 580 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 639
Query: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
FFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK +
Sbjct: 640 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 699
Query: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+
Sbjct: 700 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 757
Query: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
+LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE
Sbjct: 758 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 817
Query: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT
Sbjct: 818 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 877
Query: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+
Sbjct: 878 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 937
Query: 423 EETEGF 428
E +GF
Sbjct: 938 ENAQGF 943
Score = 42.0 bits (97), Expect = 0.001
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59
P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A R FR +
Sbjct: 185 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 244
Query: 60 YH 61
H
Sbjct: 245 RH 246
Score = 40.8 bits (94), Expect = 0.002
Identities = 16/32 (50%), Positives = 22/32 (68%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
P LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 357 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 388
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 435 bits (1118), Expect = e-122
Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY FR
Sbjct: 542 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 599
Query: 67 CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREW
Sbjct: 600 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 659
Query: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
FFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK +
Sbjct: 660 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 719
Query: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+
Sbjct: 720 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 777
Query: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
+LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE
Sbjct: 778 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 837
Query: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT
Sbjct: 838 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 897
Query: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+
Sbjct: 898 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 957
Query: 423 EETEGF 428
E +GF
Sbjct: 958 ENAQGF 963
Score = 42.0 bits (97), Expect = 0.001
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59
P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A R FR +
Sbjct: 185 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 244
Query: 60 YH 61
H
Sbjct: 245 RH 246
Score = 40.8 bits (94), Expect = 0.002
Identities = 16/32 (50%), Positives = 22/32 (68%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
P LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 377 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 408
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 435 bits (1118), Expect = e-122
Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY FR
Sbjct: 550 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 607
Query: 67 CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREW
Sbjct: 608 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 667
Query: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
FFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK +
Sbjct: 668 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 727
Query: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+
Sbjct: 728 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 785
Query: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
+LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE
Sbjct: 786 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 845
Query: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT
Sbjct: 846 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 905
Query: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+
Sbjct: 906 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 965
Query: 423 EETEGF 428
E +GF
Sbjct: 966 ENAQGF 971
Score = 42.0 bits (97), Expect = 0.001
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59
P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A R FR +
Sbjct: 193 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 252
Query: 60 YH 61
H
Sbjct: 253 RH 254
Score = 40.8 bits (94), Expect = 0.002
Identities = 16/32 (50%), Positives = 22/32 (68%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
P LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 385 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 416
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 435 bits (1118), Expect = e-122
Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY FR
Sbjct: 429 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 486
Query: 67 CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREW
Sbjct: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546
Query: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
FFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK +
Sbjct: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606
Query: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+
Sbjct: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 664
Query: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
+LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE
Sbjct: 665 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 724
Query: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT
Sbjct: 725 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 784
Query: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+
Sbjct: 785 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844
Query: 423 EETEGF 428
E +GF
Sbjct: 845 ENAQGF 850
Score = 42.0 bits (97), Expect = 0.001
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59
P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A R FR +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
Query: 60 YH 61
H
Sbjct: 132 RH 133
Score = 40.8 bits (94), Expect = 0.002
Identities = 16/32 (50%), Positives = 22/32 (68%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
P LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 264 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 435 bits (1118), Expect = e-122
Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66
LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY FR
Sbjct: 429 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 486
Query: 67 CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREW
Sbjct: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546
Query: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
FFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK +
Sbjct: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606
Query: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+
Sbjct: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 664
Query: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
+LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE
Sbjct: 665 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 724
Query: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT
Sbjct: 725 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 784
Query: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+
Sbjct: 785 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844
Query: 423 EETEGF 428
E +GF
Sbjct: 845 ENAQGF 850
Score = 42.0 bits (97), Expect = 0.001
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59
P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A R FR +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131
Query: 60 YH 61
H
Sbjct: 132 RH 133
Score = 40.8 bits (94), Expect = 0.002
Identities = 16/32 (50%), Positives = 22/32 (68%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
P LP GWE + ++G Y+V+HN RTTT+ P
Sbjct: 264 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 432 bits (1112), Expect = e-121
Identities = 220/451 (48%), Positives = 296/451 (65%), Gaps = 27/451 (5%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFE------------------------S 42
LPPGWE++ T+ G YFVDHN RTT F DPR
Sbjct: 299 LPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPD 358
Query: 43 GTKQGSPGAYDRSFRWKYHQFRF-LCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDL 101
T+ + Y R K R L H +I VSR+ +FE+S++Q+M M+P DL
Sbjct: 359 DTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDL 418
Query: 102 RRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPD 161
+RL I RGEEGLDYGG+AREW +LLSHE+LNP Y LF+Y+ + Y LQINP S++NP+
Sbjct: 419 WKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPE 478
Query: 162 HLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE 221
HL+YF F+GR + MA++HG +ID GFTLPFYK++L K TL D+E +DP+ +NS+VWI E
Sbjct: 479 HLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILE 538
Query: 222 NNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQ 281
N++ L+ F + G++ HELK G+SI V EENK+EY+ L +WRF RG+E Q
Sbjct: 539 NDITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQ 597
Query: 282 TKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFW 341
A GFNEV P L+ FDEKELEL++CG+ +ID++DW+ +T +H T +S ++WFW
Sbjct: 598 FLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFW 657
Query: 342 QVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCF 400
+ V+ D E+R RLLQFVTG+ R+P+ GF L G+ GP+ F I ++ T LP++HTCF
Sbjct: 658 KAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCF 717
Query: 401 NRLDLPPYKSYEQLREKLLYAIEETEGFGQE 431
NR+D+PPY+SYE+L EKLL AIEET GF E
Sbjct: 718 NRIDIPPYESYEKLYEKLLTAIEETCGFAVE 748
Score = 33.5 bits (75), Expect = 0.38
Identities = 19/45 (42%), Positives = 26/45 (57%), Gaps = 5/45 (11%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDP-RPGFESGTKQGSPG 50
LP GWE + T+ G +++H TRTT ++ P RP E SPG
Sbjct: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASE----YSSPG 199
Score = 33.1 bits (74), Expect = 0.50
Identities = 14/33 (42%), Positives = 20/33 (60%)
Query: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR 37
P LP G+E + T +G YF+ T +T+ DPR
Sbjct: 251 PDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPR 283
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 430 bits (1106), Expect = e-120
Identities = 218/451 (48%), Positives = 295/451 (65%), Gaps = 27/451 (5%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR------------------PGFESGTKQGS 48
LPPGWE++ T G YFVDHN RTT F DPR P G+ +
Sbjct: 308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDE 367
Query: 49 PGAYDRSFRWKYHQFRFLCHSNALPS----HVKISVSRQTLFEDSFQQIMNMKPYDLRRR 104
R R + + L H +L H +I VSR+ +FE+S++QIM M+P DL++R
Sbjct: 368 ELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKR 427
Query: 105 LYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLT 164
L + RGEEGLDYGG+AREW +LL HE+LNP Y LF+Y+ N Y LQINP SSINPDHL+
Sbjct: 428 LMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLS 487
Query: 165 YFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNL 224
YF F+GR + +A++HG +I+ GFT+PFYK++L K L DLES+DPE + S+VWI EN++
Sbjct: 488 YFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDI 547
Query: 225 EECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKA 284
L+ F + G++ HELK G ++ VTEENK+EY+ L +WRF RG+E Q A
Sbjct: 548 TPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLA 606
Query: 285 FLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVV 344
GFNE+ P L+ FD+KELEL++ G+ +ID++DW+ +T +H +S ++WFWQ V
Sbjct: 607 LQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAV 666
Query: 345 KEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSN---GPQKFCIDKVGKET-WLPRSHTCF 400
+ D E+R RLLQFVTG+ R+P+ GF L GS GP+ F I + T LP++HTCF
Sbjct: 667 ETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCF 726
Query: 401 NRLDLPPYKSYEQLREKLLYAIEETEGFGQE 431
NR+D+PPY+SYE+L EKLL A+EET GF E
Sbjct: 727 NRIDIPPYESYEKLYEKLLTAVEETCGFAVE 757
Score = 41.2 bits (95), Expect = 0.002
Identities = 22/59 (37%), Positives = 30/59 (50%)
Query: 3 QEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYH 61
Q P LP G+E + T +G YF+ T +T+ DPR SGT G A+ F + H
Sbjct: 232 QSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGH 290
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 430 bits (1106), Expect = e-120
Identities = 218/451 (48%), Positives = 295/451 (65%), Gaps = 27/451 (5%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR------------------PGFESGTKQGS 48
LPPGWE++ T G YFVDHN RTT F DPR P G+ +
Sbjct: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDE 341
Query: 49 PGAYDRSFRWKYHQFRFLCHSNALPS----HVKISVSRQTLFEDSFQQIMNMKPYDLRRR 104
R R + + L H +L H +I VSR+ +FE+S++QIM M+P DL++R
Sbjct: 342 ELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKR 401
Query: 105 LYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLT 164
L + RGEEGLDYGG+AREW +LL HE+LNP Y LF+Y+ N Y LQINP SSINPDHL+
Sbjct: 402 LMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLS 461
Query: 165 YFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNL 224
YF F+GR + +A++HG +I+ GFT+PFYK++L K L DLES+DPE + S+VWI EN++
Sbjct: 462 YFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDI 521
Query: 225 EECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKA 284
L+ F + G++ HELK G ++ VTEENK+EY+ L +WRF RG+E Q A
Sbjct: 522 TPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLA 580
Query: 285 FLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVV 344
GFNE+ P L+ FD+KELEL++ G+ +ID++DW+ +T +H +S ++WFWQ V
Sbjct: 581 LQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAV 640
Query: 345 KEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSN---GPQKFCIDKVGKET-WLPRSHTCF 400
+ D E+R RLLQFVTG+ R+P+ GF L GS GP+ F I + T LP++HTCF
Sbjct: 641 ETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCF 700
Query: 401 NRLDLPPYKSYEQLREKLLYAIEETEGFGQE 431
NR+D+PPY+SYE+L EKLL A+EET GF E
Sbjct: 701 NRIDIPPYESYEKLYEKLLTAVEETCGFAVE 731
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 363 bits (931), Expect = e-100
Identities = 186/389 (47%), Positives = 251/389 (64%), Gaps = 6/389 (1%)
Query: 48 SPGAYDRSFRWKYHQFRFLCHSNAL---PSHVKISVSRQTLFEDSFQQIMNMKPYDLRR- 103
+P Y R F K F + P +K+ + R L ED+F QIM DL+R
Sbjct: 1185 APAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRN 1244
Query: 104 RLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHL 163
+LY+ GEEGLDY G +RE+FFL+S E+ NP Y LFEY+ + Y +QI+P S+ +H
Sbjct: 1245 KLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH 1304
Query: 164 TYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENN 223
+FRF GR + +AL H +D FT PFYK +L L DLE +D EF+ S+ W+K+N+
Sbjct: 1305 EWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDND 1364
Query: 224 LEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTK 283
+ + L+L F + E+ G++T ELK GG +I VTE+NK+EYI + WR RGV +QT+
Sbjct: 1365 IHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTE 1423
Query: 284 AFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQ 342
+ + GF EV + FD +ELEL++ G EID+SDW+ +T YR Y N I+WFW
Sbjct: 1424 SLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWA 1483
Query: 343 VVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNR 402
V+ +NE+R+RLLQFVTGT +P GFA L GSNGP++FC++K GK T LPR+HTCFNR
Sbjct: 1484 AVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNR 1543
Query: 403 LDLPPYKSYEQLREKLLYAIEETEGFGQE 431
LDLPPY S+ L EKLL A+EET FG E
Sbjct: 1544 LDLPPYPSFSMLYEKLLTAVEETSTFGLE 1572
Score = 51.6 bits (122), Expect = 1e-06
Identities = 22/36 (61%), Positives = 27/36 (75%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFES 42
LP GWEMK+ +G +FVDHN+RTTTF DPR +S
Sbjct: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQS 1022
Score = 39.3 bits (90), Expect = 0.007
Identities = 16/33 (48%), Positives = 22/33 (66%)
Query: 4 EPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
+ ALPP WE + S G ++VDH RTTT++ P
Sbjct: 806 DEALPPNWEARIDSHGRIFYVDHVNRTTTWQRP 838
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 360 bits (923), Expect = 2e-99
Identities = 188/399 (47%), Positives = 254/399 (63%), Gaps = 7/399 (1%)
Query: 38 PGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNAL---PSHVKISVSRQTLFEDSFQQIM 94
PG + + + +P Y R F K F + P +K+ + R L E +F Q+M
Sbjct: 1210 PGLQRASAR-APSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268
Query: 95 NMKPYDLRR-RLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQIN 153
+L+R +LY+ GEEGLDY G +RE+FFLLS E+ NP Y LFEY+ + Y +QI+
Sbjct: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328
Query: 154 PASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFY 213
P S+ +HL +FRF GR + +AL H +D FT PFYK +L L DLE +D EF+
Sbjct: 1329 PMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFH 1388
Query: 214 NSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWR 273
S+ W+K+NN+ + L+L F + E+ G+VT ELK GG + +VTE+NK+EYI + WR
Sbjct: 1389 QSLQWMKDNNITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
Query: 274 FTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYR-HYTK 332
RGV +QT+A + GF EV + FD +ELEL++ G EID++DW+ +T YR Y
Sbjct: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
Query: 333 NSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETW 392
I+WFW V+ +NE+R+RLLQFVTGT +P GFA L GSNG ++FCI+K GK T
Sbjct: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
Query: 393 LPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE 431
LPR+HTCFNRLDLPPY SY L EKLL A+EET FG E
Sbjct: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1606
Score = 48.1 bits (113), Expect = 2e-05
Identities = 20/37 (54%), Positives = 26/37 (70%)
Query: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESG 43
LP GWE+K +G +FVDHN+R TTF DPR ++G
Sbjct: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNG 1056
Score = 38.9 bits (89), Expect = 0.009
Identities = 18/35 (51%), Positives = 23/35 (65%), Gaps = 1/35 (2%)
Query: 2 IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
I EP LPP WE + S G ++VDH RTTT++ P
Sbjct: 827 IDEP-LPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 321 bits (823), Expect = 7e-88
Identities = 156/354 (44%), Positives = 227/354 (64%), Gaps = 2/354 (0%)
Query: 78 ISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMY 137
+ V R +FEDS++++ P +++ RLYI+ GEEG D GG+ REW+ ++S E+ NPMY
Sbjct: 4019 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMY 4078
Query: 138 CLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLN 197
LF + + INP+S NP+HL+YF+F+GR +A A+Y + ++ FT FYK +L
Sbjct: 4079 ALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILG 4138
Query: 198 KRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRV 257
K D+ES D FY +V++ EN++ G +L F +++ G +LK G +I V
Sbjct: 4139 KSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILV 4198
Query: 258 TEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEID 317
TEENK+EY+ L+ R T + +Q AFL+GF E+ P + F E+ELEL++ G+ ID
Sbjct: 4199 TEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTID 4258
Query: 318 MSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSN 377
+ D + +T Y Y NS QIQWFW+ ++ D R + LQFVTGT ++P+ GFA L G N
Sbjct: 4259 IDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMN 4318
Query: 378 GPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEE-TEGFG 429
G QKF I + + T LP +HTCFN+LDLP Y+S+E+LR LL AI+E +EGFG
Sbjct: 4319 GIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFG 4372
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 279 bits (714), Expect = 3e-75
Identities = 147/345 (42%), Positives = 211/345 (61%), Gaps = 4/345 (1%)
Query: 80 VSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCL 139
V R ++F S + + L++ + + GEEG+ G + REWF +LS+E++NP Y L
Sbjct: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYAL 615
Query: 140 FEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKR 199
F + Q N S +NPDHL YFRF G+ + +AL H + ++ FT FYK +L
Sbjct: 616 FTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP 674
Query: 200 PTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTE 259
+D+ SIDPE+ ++ WI +N++ + GLEL F + ++ G + LK GG SI VT+
Sbjct: 675 VNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQ 734
Query: 260 ENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMS 319
NK EY+ L+T+ R TR ++ Q AFL GF+ P ++ FDE ELEL+L GM EID+S
Sbjct: 735 NNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVS 794
Query: 320 DWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNG 378
DW K+T Y Y + IQWFW+VV+++ E+R+ LLQFVTG+ R+P GGFA ++G +G
Sbjct: 795 DWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSG 854
Query: 379 PQKFCIDKVG-KETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
Q F I V LP S TC N L LP Y S E L+++LL A+
Sbjct: 855 LQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 213 bits (541), Expect = 4e-55
Identities = 128/374 (34%), Positives = 211/374 (56%), Gaps = 23/374 (6%)
Query: 66 LCHSNALPSHVKISVSRQTLFEDSF---QQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAR 122
L L ++++ V R + +D+ + I P DL+++LY+ GE+G+D GG+++
Sbjct: 510 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 569
Query: 123 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKF 182
E+F L+ E+ NP +F Y ++ NP+S T IG + +A+Y+
Sbjct: 570 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFETEGQFT---LIGIVLGLAIYNNCI 625
Query: 183 IDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE--NNLEECGLELYFIQDMEIL 240
+D F + Y++++ K+ T +DL P Y S+ + E N+E+ + + I ++
Sbjct: 626 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 685
Query: 241 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEV---APLEW 297
G ++LKE G+ I +T EN++E++ L +D+ + VE+Q KAF GF+ V +PL++
Sbjct: 686 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 745
Query: 298 LRYFDEKELELMLCGMQEIDMSDWQKSTIY-RHYTKNSKQIQWFWQVVKEMDNEKRIRLL 356
L F +E+EL++CG + +D +++T Y YT++S I+ FW++V +E++ L
Sbjct: 746 L--FRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFL 803
Query: 357 QFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLR 415
QF TGT R PVGG +L K I K G +T LP SHTCFN L LP Y S E+L+
Sbjct: 804 QFTTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLK 856
Query: 416 EKLLYAIEETEGFG 429
E+LL AI +GFG
Sbjct: 857 ERLLKAITYAKGFG 870
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 213 bits (541), Expect = 4e-55
Identities = 128/374 (34%), Positives = 211/374 (56%), Gaps = 23/374 (6%)
Query: 66 LCHSNALPSHVKISVSRQTLFEDSF---QQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAR 122
L L ++++ V R + +D+ + I P DL+++LY+ GE+G+D GG+++
Sbjct: 490 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 549
Query: 123 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKF 182
E+F L+ E+ NP +F Y ++ NP+S T IG + +A+Y+
Sbjct: 550 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFETEGQFT---LIGIVLGLAIYNNCI 605
Query: 183 IDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE--NNLEECGLELYFIQDMEIL 240
+D F + Y++++ K+ T +DL P Y S+ + E N+E+ + + I ++
Sbjct: 606 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 665
Query: 241 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEV---APLEW 297
G ++LKE G+ I +T EN++E++ L +D+ + VE+Q KAF GF+ V +PL++
Sbjct: 666 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 725
Query: 298 LRYFDEKELELMLCGMQEIDMSDWQKSTIY-RHYTKNSKQIQWFWQVVKEMDNEKRIRLL 356
L F +E+EL++CG + +D +++T Y YT++S I+ FW++V +E++ L
Sbjct: 726 L--FRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFL 783
Query: 357 QFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLR 415
QF TGT R PVGG +L K I K G +T LP SHTCFN L LP Y S E+L+
Sbjct: 784 QFTTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLK 836
Query: 416 EKLLYAIEETEGFG 429
E+LL AI +GFG
Sbjct: 837 ERLLKAITYAKGFG 850
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 213 bits (541), Expect = 4e-55
Identities = 128/374 (34%), Positives = 211/374 (56%), Gaps = 23/374 (6%)
Query: 66 LCHSNALPSHVKISVSRQTLFEDSF---QQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAR 122
L L ++++ V R + +D+ + I P DL+++LY+ GE+G+D GG+++
Sbjct: 513 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 572
Query: 123 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKF 182
E+F L+ E+ NP +F Y ++ NP+S T IG + +A+Y+
Sbjct: 573 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFETEGQFT---LIGIVLGLAIYNNCI 628
Query: 183 IDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE--NNLEECGLELYFIQDMEIL 240
+D F + Y++++ K+ T +DL P Y S+ + E N+E+ + + I ++
Sbjct: 629 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 688
Query: 241 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEV---APLEW 297
G ++LKE G+ I +T EN++E++ L +D+ + VE+Q KAF GF+ V +PL++
Sbjct: 689 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 748
Query: 298 LRYFDEKELELMLCGMQEIDMSDWQKSTIY-RHYTKNSKQIQWFWQVVKEMDNEKRIRLL 356
L F +E+EL++CG + +D +++T Y YT++S I+ FW++V +E++ L
Sbjct: 749 L--FRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFL 806
Query: 357 QFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLR 415
QF TGT R PVGG +L K I K G +T LP SHTCFN L LP Y S E+L+
Sbjct: 807 QFTTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLK 859
Query: 416 EKLLYAIEETEGFG 429
E+LL AI +GFG
Sbjct: 860 ERLLKAITYAKGFG 873
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 203 bits (517), Expect = 2e-52
Identities = 128/373 (34%), Positives = 199/373 (53%), Gaps = 30/373 (8%)
Query: 76 VKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNP 135
+ + V R L DS ++ K DL+++L + GE GLD GG+ +EWF LL ++ +P
Sbjct: 417 LNMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHP 475
Query: 136 MYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRM 195
Y +F Y K+++C SS D+ + FR +G + +A+Y+ +D F YK++
Sbjct: 476 DYGMFTYH-KDSHCHWF---SSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
Query: 196 LNK--------------RPTLKDLESIDPEFYNSIVWI--KENNLEECGLELYFIQDMEI 239
L+ T+ DL I PE + + + E N+EE + + E
Sbjct: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
Query: 240 LGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLR 299
G + ++ LK GG+ I VT +N++EY+ L TD+ + + +Q AF GF+ V L
Sbjct: 592 -GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALM 650
Query: 300 YFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 359
+E+E+++CG ++DM Q+ST Y Y K I++FW VV + + +LL F
Sbjct: 651 LLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
Query: 360 TGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREKL 418
TG+ R+PVGG A+L F I K T LP +HTCFN+L LPPYKS + L++KL
Sbjct: 711 TGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
Query: 419 LYAIEETEGFGQE 431
+ I +EGFG E
Sbjct: 764 IIGISNSEGFGLE 776
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 198 bits (503), Expect = 9e-51
Identities = 136/379 (35%), Positives = 189/379 (49%), Gaps = 28/379 (7%)
Query: 68 HSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFL 127
H S V + VSR L E S + N D + ++ + EE LD+GG REWF L
Sbjct: 454 HMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFEL 513
Query: 128 LSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTY--FRFIGRFIAMALYHG----- 180
+ + + LF NN L ++P + P HL + F GR + LY
Sbjct: 514 ICKALFDTTNQLFTRFSDNNQAL-VHPNPN-RPAHLRLKMYEFAGRLVGKCLYESSLGGA 571
Query: 181 --KFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNS-IVWIKENNLEECGLELYFIQDM 237
+ + FT F +++ R K E+ DPEFY S + +I N++ E +EL F ++
Sbjct: 572 YKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSE--MELVFAEEK 629
Query: 238 EI----LGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVA 293
L KV EL GG VT NK Y+ LL +R V+E+ + FL G NE+
Sbjct: 630 YNKSGQLDKVV--ELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELV 687
Query: 294 PLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIY--RHYTKNSKQIQWFWQVVKEMDNEK 351
P L FDE ELEL++CG +I +SD++ + + K ++WFW VV + E+
Sbjct: 688 PENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEE 747
Query: 352 RIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSY 411
RLLQF TG+ +LP GGFA L S F I + LP +HTCFN+L LP Y SY
Sbjct: 748 LARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHSTLPTAHTCFNQLCLPTYDSY 802
Query: 412 EQLREKLLYAIEE-TEGFG 429
E++ L AI E EGFG
Sbjct: 803 EEVHRMLQLAISEGCEGFG 821
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 179 bits (454), Expect = 4e-45
Identities = 114/354 (32%), Positives = 184/354 (51%), Gaps = 17/354 (4%)
Query: 80 VSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCL 139
V R+ + D+ + + K D ++ L +I GE+ +D GG+ +E+F L+ E+L+P Y +
Sbjct: 705 VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 764
Query: 140 FEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKR 199
F Y +++ + + + + D F IG +A+Y+ +D F L YK++L K+
Sbjct: 765 FRYY-EDSRLIWFSDKTFEDSD---LFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 820
Query: 200 PTLKDLESIDPEFYNSIVWI---KENNLEECGLELYFIQDMEILGKVTTHELKEGGESIR 256
P+L DL+ + P+ S+ + E+++EE L F +E G EL G
Sbjct: 821 PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFC-LNFTITVENFGATEVKELVLNGADTA 879
Query: 257 VTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEI 316
V ++N++E++ D+ F + V AF GF++V + L F EL+ M+ G
Sbjct: 880 VNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNY 939
Query: 317 DMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIG 375
D + +K+T Y+ Y I+ FW+V E+ EK+ + L F+TG+ R+P+ G L
Sbjct: 940 DWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL-- 997
Query: 376 SNGPQKFCIDKVGK-ETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 428
K I G E +LP SHTCFN LDLP Y E LR KL+ AI+ EGF
Sbjct: 998 -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 179 bits (454), Expect = 4e-45
Identities = 114/354 (32%), Positives = 184/354 (51%), Gaps = 17/354 (4%)
Query: 80 VSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCL 139
V R+ + D+ + + K D ++ L +I GE+ +D GG+ +E+F L+ E+L+P Y +
Sbjct: 713 VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 772
Query: 140 FEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKR 199
F Y +++ + + + + D F IG +A+Y+ +D F L YK++L K+
Sbjct: 773 FRYY-EDSRLIWFSDKTFEDSD---LFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 828
Query: 200 PTLKDLESIDPEFYNSIVWI---KENNLEECGLELYFIQDMEILGKVTTHELKEGGESIR 256
P+L DL+ + P+ S+ + E+++EE L F +E G EL G
Sbjct: 829 PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFC-LNFTITVENFGATEVKELVLNGADTA 887
Query: 257 VTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEI 316
V ++N++E++ D+ F + V AF GF++V + L F EL+ M+ G
Sbjct: 888 VNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNY 947
Query: 317 DMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIG 375
D + +K+T Y+ Y I+ FW+V E+ EK+ + L F+TG+ R+P+ G L
Sbjct: 948 DWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL-- 1005
Query: 376 SNGPQKFCIDKVGK-ETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 428
K I G E +LP SHTCFN LDLP Y E LR KL+ AI+ EGF
Sbjct: 1006 -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1054
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 178 bits (452), Expect = 7e-45
Identities = 120/367 (32%), Positives = 191/367 (52%), Gaps = 23/367 (6%)
Query: 76 VKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRG-----EEGLDYGGIAREWFFLLSH 130
+ +++ R ++ED++ ++ DL++R+ + + E G+D GGI RE+ L
Sbjct: 723 INVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLK 782
Query: 131 EVLNPMYCLFEYAGKNNYCLQINPASS--INPDHLTYFRFIGRFIAMALYHGKFIDTGFT 188
NP F+ N L NPA+ + ++ F+GR + ALY ++ F
Sbjct: 783 SGFNPNQGFFKTT--NEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFA 840
Query: 189 LPFYKRMLNKRPT--LKDLESIDPEFYNSIVWIK--ENNLEECGLELYFIQDMEILGKVT 244
F ++L + L S+DPE Y +++++K E+++EE GL + + LG+
Sbjct: 841 GFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNND--LGEAQ 898
Query: 245 THELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEK 304
ELK GG+ I VT N+ YI L+ D+R R + + AF G V LEWLR FD++
Sbjct: 899 VVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQ 958
Query: 305 ELELMLCGMQ-EIDMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
E+++++ G Q I + D + T Y Y+ + I+ FW+VV+ +E++ +LL+FVT
Sbjct: 959 EIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSC 1018
Query: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKE-TWLPRSHTCFNRLDLPPYKSYEQLREKLLYA 421
R P+ GF EL + FCI G + LP + TC N L LP + LR KLLYA
Sbjct: 1019 SRPPLLGFKELYPA-----FCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYA 1073
Query: 422 IEETEGF 428
IE GF
Sbjct: 1074 IECAAGF 1080
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.140 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,861,470
Number of Sequences: 37866
Number of extensions: 821847
Number of successful extensions: 1771
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1470
Number of HSP's gapped (non-prelim): 142
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.