Search of human proteins with 40255047

Search of human proteins with 40255047

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40255047 pleckstrin homology domain containing, family H
(with MyTH4 domain) member 3 [Homo sapiens]
         (793 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40255047 pleckstrin homology domain containing, family H (wit...  1616   0.0  
gi|154354979 myosin X [Homo sapiens]                                  437   e-122
gi|55741447 pleckstrin homology domain containing, family H (wit...    78   3e-14
gi|217416392 pleckstrin homology domain containing, family H (wi...    68   4e-11
gi|189083802 myosin VIIA isoform 2 [Homo sapiens]                      56   1e-07
gi|189083798 myosin VIIA isoform 1 [Homo sapiens]                      56   1e-07
gi|122937512 myosin VIIB [Homo sapiens]                                45   2e-04
gi|239754368 PREDICTED: hypothetical protein [Homo sapiens]            45   3e-04
gi|239748915 PREDICTED: hypothetical protein XP_002346855 [Homo ...    45   3e-04
gi|239742939 PREDICTED: hypothetical protein XP_002342693 [Homo ...    45   3e-04
gi|169213235 PREDICTED: hypothetical protein [Homo sapiens]            44   4e-04
gi|169212744 PREDICTED: hypothetical protein [Homo sapiens]            44   4e-04
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...    43   0.001
gi|118402590 myosin XV [Homo sapiens]                                  43   0.001
gi|169164209 PREDICTED: hypothetical protein [Homo sapiens]            43   0.001
gi|239741571 PREDICTED: hypothetical protein XP_002342241 [Homo ...    43   0.001
gi|13994190 frizzled 8 [Homo sapiens]                                  43   0.001
gi|139394646 iroquois homeobox protein 5 [Homo sapiens]                43   0.001
gi|46430491 scratch 2 protein [Homo sapiens]                           42   0.002
gi|36029914 valosin containing protein (p97)/p47 complex interac...    42   0.003
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    41   0.004
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [...    41   0.004
gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]              41   0.004
gi|239751929 PREDICTED: hypothetical protein [Homo sapiens]            41   0.005
gi|239746415 PREDICTED: hypothetical protein XP_002344217 [Homo ...    41   0.005
gi|237757310 synaptojanin 1 isoform a [Homo sapiens]                   40   0.008
gi|237757308 synaptojanin 1 isoform b [Homo sapiens]                   40   0.008
gi|82546824 forkhead box K1 [Homo sapiens]                             40   0.008
gi|224465238 hypothetical protein LOC283999 [Homo sapiens]             40   0.011
gi|239754991 PREDICTED: hypothetical protein isoform 1 [Homo sap...    40   0.011

>gi|40255047 pleckstrin homology domain containing, family H (with
           MyTH4 domain) member 3 [Homo sapiens]
          Length = 793

 Score = 1616 bits (4184), Expect = 0.0
 Identities = 793/793 (100%), Positives = 793/793 (100%)

Query: 1   MPLPGGLWWLLCCRRGFTLLHRDYGDGELSGDGDEDEDEETFELRTPSPAGGGRGPLEVT 60
           MPLPGGLWWLLCCRRGFTLLHRDYGDGELSGDGDEDEDEETFELRTPSPAGGGRGPLEVT
Sbjct: 1   MPLPGGLWWLLCCRRGFTLLHRDYGDGELSGDGDEDEDEETFELRTPSPAGGGRGPLEVT 60

Query: 61  LTQPVRSGPVSNRLQSWEETWSLIPEKGLPEDDPDIVVKGWLYREPRGGGARPWLPPRRA 120
           LTQPVRSGPVSNRLQSWEETWSLIPEKGLPEDDPDIVVKGWLYREPRGGGARPWLPPRRA
Sbjct: 61  LTQPVRSGPVSNRLQSWEETWSLIPEKGLPEDDPDIVVKGWLYREPRGGGARPWLPPRRA 120

Query: 121 WFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVTGPERRRKETGLWSVTVSGRKHSVRLC 180
           WFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVTGPERRRKETGLWSVTVSGRKHSVRLC
Sbjct: 121 WFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVTGPERRRKETGLWSVTVSGRKHSVRLC 180

Query: 181 SPRQAEAERWGVALREVIASKAPLETPTQLLLRDIQESCGDPEAVALIYLRNPILRHTSG 240
           SPRQAEAERWGVALREVIASKAPLETPTQLLLRDIQESCGDPEAVALIYLRNPILRHTSG
Sbjct: 181 SPRQAEAERWGVALREVIASKAPLETPTQLLLRDIQESCGDPEAVALIYLRNPILRHTSG 240

Query: 241 ALYAPLLPLPYGVSAPGPGYAPLREEAVRLFLALQALEGARRPGPLMQGVLQTCRDLPAL 300
           ALYAPLLPLPYGVSAPGPGYAPLREEAVRLFLALQALEGARRPGPLMQGVLQTCRDLPAL
Sbjct: 241 ALYAPLLPLPYGVSAPGPGYAPLREEAVRLFLALQALEGARRPGPLMQGVLQTCRDLPAL 300

Query: 301 RDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERT 360
           RDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERT
Sbjct: 301 RDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERT 360

Query: 361 EQALPDSELAEYARFIRKALGRTRGRELVPSLAEISALSQRQELLCTVHCPGAGACAVAI 420
           EQALPDSELAEYARFIRKALGRTRGRELVPSLAEISALSQRQELLCTVHCPGAGACAVAI
Sbjct: 361 EQALPDSELAEYARFIRKALGRTRGRELVPSLAEISALSQRQELLCTVHCPGAGACAVAI 420

Query: 421 DSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGTLVADVLTRFENLAAEEA 480
           DSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGTLVADVLTRFENLAAEEA
Sbjct: 421 DSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGTLVADVLTRFENLAAEEA 480

Query: 481 GLEDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAA 540
           GLEDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAA
Sbjct: 481 GLEDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAA 540

Query: 541 LRLQSLHRDFSPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALLAGALWSPGLAKRR 600
           LRLQSLHRDFSPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALLAGALWSPGLAKRR
Sbjct: 541 LRLQSLHRDFSPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALLAGALWSPGLAKRR 600

Query: 601 AERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMAAYLALAAQCPGFG 660
           AERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMAAYLALAAQCPGFG
Sbjct: 601 AERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMAAYLALAAQCPGFG 660

Query: 661 AARYDVLELSTEPGRGAPQKLCLGLGAKAMSLSRPGETEPIHSVSYGHVAACQLMGPHTL 720
           AARYDVLELSTEPGRGAPQKLCLGLGAKAMSLSRPGETEPIHSVSYGHVAACQLMGPHTL
Sbjct: 661 AARYDVLELSTEPGRGAPQKLCLGLGAKAMSLSRPGETEPIHSVSYGHVAACQLMGPHTL 720

Query: 721 ALRVGESQLLLQSPQVEEIMQLVNAYLANPSPERPCSSSSPPCQDLPDTSPPSQRPGLDE 780
           ALRVGESQLLLQSPQVEEIMQLVNAYLANPSPERPCSSSSPPCQDLPDTSPPSQRPGLDE
Sbjct: 721 ALRVGESQLLLQSPQVEEIMQLVNAYLANPSPERPCSSSSPPCQDLPDTSPPSQRPGLDE 780

Query: 781 PQGQSGCLGQLQD 793
           PQGQSGCLGQLQD
Sbjct: 781 PQGQSGCLGQLQD 793


>gi|154354979 myosin X [Homo sapiens]
          Length = 2058

 Score =  437 bits (1123), Expect = e-122
 Identities = 265/690 (38%), Positives = 390/690 (56%), Gaps = 47/690 (6%)

Query: 95   DIVVKGWLYREPRGGGARPWLPPRRAWFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVT 154
            + +V+GWL++E +       L  ++ WFVLT +SLD + SS K A +LG+LVL SLCSV 
Sbjct: 1392 EFIVRGWLHKEVKNSPKMSSLKLKKRWFVLTHNSLDYYKSSEKNALKLGTLVLNSLCSVV 1451

Query: 155  GPERRR-KETGLWSVTVSGRKHSVRLCSPRQAEAERWGVALREVIASKAPLETPTQLLLR 213
             P+ +  KETG W+VTV GRKH  RL +    EA RW  A++ V  +KAP++TPTQ L++
Sbjct: 1452 PPDEKIFKETGYWNVTVYGRKHCYRLYTKLLNEATRWSSAIQNVTDTKAPIDTPTQQLIQ 1511

Query: 214  DIQESCGDPEAVALIYLRNPILRHTSGALYAPLLPLPYGVS----APGPGYAPLREEAVR 269
            DI+E+C + + V  IY RNPILR+T   L++PLLPLPYG          GY  L++EA++
Sbjct: 1512 DIKENCLNSDVVEQIYKRNPILRYTHHPLHSPLLPLPYGDINLNLLKDKGYTTLQDEAIK 1571

Query: 270  LFLALQALEGARRPGPLMQGVLQTCRDLPALRDELFLQLAKQTSGPAGPPGLPATQDPAA 329
            +F +LQ LE    P P++QG+LQT  DL  LRDEL+ QL KQT+    P  +        
Sbjct: 1572 IFNSLQQLESMSDPIPIIQGILQTGHDLRPLRDELYCQLIKQTNKVPHPGSV------GN 1625

Query: 330  LRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQALPDSELAEYARFIRKALGRTRGRELV 389
            L  WQ+LTC+SCTF P   +  +L  HL+R  +  P SE+ +YA F  ++L +T+ RE V
Sbjct: 1626 LYSWQILTCLSCTFLPSRGILKYLKFHLKRIREQFPGSEMEKYALFTYESLKKTKCREFV 1685

Query: 390  PSLAEISALSQRQELLCTVHCPGAGACAVAIDSHTTAGEVARELVGRLGLARSRNAFALY 449
            PS  EI AL  RQE+  TV+C G G+C + I+SHTTAGEV  +L+  L +  SRN FAL+
Sbjct: 1686 PSRDEIEALIHRQEMTSTVYCHGGGSCKITINSHTTAGEVVEKLIRGLAMEDSRNMFALF 1745

Query: 450  EQRGAQERALAGGTLVADVLTRFENLAA-EEAGLEDSPDSGWRLCLRLHGPLHPEGLSPD 508
            E  G  ++A+   T+VADVL +FE LAA  E G     D  W+   +L+  L  + +  D
Sbjct: 1746 EYNGHVDKAIESRTVVADVLAKFEKLAATSEVG-----DLPWKFYFKLYCFLDTDNVPKD 1800

Query: 509  GHELPFLFEQAHALLLRGRPPPPDDTLRALAALRLQSLHRDFSPRVPLPRLDRLLPPPAP 568
              E  F+FEQAH  ++ G  P P++ L+ LAALRLQ L  D++    +P L+ +      
Sbjct: 1801 SVEFAFMFEQAHEAVIHGHHPAPEENLQVLAALRLQYLQGDYTLHAAIPPLEEVY----- 1855

Query: 569  PREDPPRPTPRPPPSAALLAGALWSPGLAKRRAERARRGGAGRT--AGSIARE------- 619
                  R   R   S            L KRR      G   R+   GS+ R+       
Sbjct: 1856 ---SLQRLKARISQSTKTFTPC---ERLEKRRTS-FLEGTLRRSFRTGSVVRQKVEEEQM 1908

Query: 620  -----GGGGAGTAAAVLGGWKRLRGMGRAEAMAAYLALAAQCPGFGAARYDVLELSTEPG 674
                     +   A+++  W++ +GM + +AMA Y+AL  + PG+G+  +DV     + G
Sbjct: 1909 LDMWIKEEVSSARASIIDKWRKFQGMNQEQAMAKYMALIKEWPGYGSTLFDV---ECKEG 1965

Query: 675  RGAPQKLCLGLGAKAMSLSRPGETEPIHSVSYGHVAACQLMGPHTLALRVGESQLLLQSP 734
             G PQ+L LG+ A A+S+ + GE  P+    Y H+ +      +T  + V E +LL ++ 
Sbjct: 1966 -GFPQELWLGVSADAVSVYKRGEGRPLEVFQYEHILSFGAPLANTYKIVVDERELLFETS 2024

Query: 735  QVEEIMQLVNAYLANPSPERPCSSSSPPCQ 764
            +V ++ +L+ AY++    +R  ++ S   Q
Sbjct: 2025 EVVDVAKLMKAYISMIVKKRYSTTRSASSQ 2054



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 29/134 (21%), Positives = 60/134 (44%), Gaps = 18/134 (13%)

Query: 74   LQSWEETWSLIPEKGLP--EDDPDIVVKGWLYREPRGGGA-----RPWLPPRRAWFVLTR 126
            + SW+  W ++ ++         + + +GWL++  +GGG+     R W   ++ WFVL +
Sbjct: 1189 MNSWKRRWCVLKDETFLWFRSKQEALKQGWLHK--KGGGSSTLSRRNW---KKRWFVLRQ 1243

Query: 127  DSLDQFSSSGKGARRLGSLVLTSLCSVTGPERRRKETGLWSVTVSGRKHSVRLCSPRQAE 186
              L  F +  +  +  G++ + +   +   +   KE G+  +      H   L +    +
Sbjct: 1244 SKLMYFENDSE-EKLKGTVEVRTAKEII--DNTTKENGIDIIMADRTFH---LIAESPED 1297

Query: 187  AERWGVALREVIAS 200
            A +W   L +V AS
Sbjct: 1298 ASQWFSVLSQVHAS 1311


>gi|55741447 pleckstrin homology domain containing, family H (with
            MyTH4 domain) member 1 [Homo sapiens]
          Length = 1364

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 117/485 (24%), Positives = 183/485 (37%), Gaps = 78/485 (16%)

Query: 200  SKAPLETPTQLLLRDIQESCGDPEAVALIYLRNPILRHTSGALYAPLLPLPYGVSAPGPG 259
            S A + T  + L+  + +  GDP++      R+P+L ++   LYA L  LP         
Sbjct: 798  SSAKVGTAYEQLIGKLMDGEGDPDSPLW---RHPMLCYSKDGLYASLTTLPSEA------ 848

Query: 260  YAPLREEAVRLFLALQALEGARRPGP-------LMQGVLQTCRDLPALRDELFLQLAKQT 312
               L+ EA++LF + Q                 L Q  LQ C   P L+ E++ QL KQT
Sbjct: 849  ---LQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIYCQLMKQT 905

Query: 313  SGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQ--ALPDSELA 370
            S    PP     Q  + ++ WQLL   +  F P    + H L ++++  Q  A P SE  
Sbjct: 906  S--CRPP-----QKYSLMQCWQLLALCAPLFLP----QHHFLWYVKQQLQRHADPRSETG 954

Query: 371  EYARFIRKALG---RTRGRELVPSLAEISALSQRQ------ELLCTVHCPGAGACAVAID 421
            +YA + ++A+    RT  RE  PS  E+ ++  R            VH        V  D
Sbjct: 955  QYATYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFD 1014

Query: 422  SHTTAGEVARELVGRLGLAR-SRNAFALYEQRGA---QERALAGGTLVADVLTRFENLAA 477
              +T  E  + L   +G+ + S + FAL+    +    E  L G   + D ++++E    
Sbjct: 1015 GSSTVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMK 1074

Query: 478  E-EAGLEDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLR 536
            E   G  +      +L  +       +       E   L  Q    ++ GR P   +   
Sbjct: 1075 ELHPGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELAL 1134

Query: 537  ALAALRLQSLHRDFSPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALLAGALWSPGL 596
             +AAL  Q  + D             L  PA          P P  ++   A  L    L
Sbjct: 1135 EMAALMAQVEYGD-------------LEKPA---------LPGPGGTSPAKAQHLLQQVL 1172

Query: 597  AKRRAERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMAAYLALAAQC 656
             +    R R G        +          A  +   W  L+G    E +  YL +A + 
Sbjct: 1173 DRFHPRRYRHGAPAEQLRHL----------ADMLTTKWATLQGCSPPECIRIYLTVARKW 1222

Query: 657  PGFGA 661
            P FGA
Sbjct: 1223 PFFGA 1227


>gi|217416392 pleckstrin homology domain containing, family H (with
            MyTH4 domain) member 2 [Homo sapiens]
          Length = 1493

 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 106/451 (23%), Positives = 162/451 (35%), Gaps = 68/451 (15%)

Query: 231  RNPILRHTSGALYAPLLPLPYGVSAPGPGYAPLREEAVRLFLALQALEGARRPGP----- 285
            R+P L H+   + +PL  LP            L+ EA++LF   Q    A    P     
Sbjct: 949  RHPTLCHSKEGIISPLTTLPSEA---------LQTEAIKLFKTCQLFINAAVDSPAIDYH 999

Query: 286  --LMQGVLQTCRDLPALRDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTF 343
              L Q  LQ C   P L++E+  QL KQT         P  Q P  L+ WQLL      F
Sbjct: 1000 ISLAQSALQICLTHPELQNEICCQLIKQTRRRQ-----PQNQ-PGPLQGWQLLALCVGLF 1053

Query: 344  RPGGAVRGHLLGHLERTEQALPDSELAEYARFIRKALGRTR---GRELVPSLAEISALSQ 400
             P       L  HL+R   +   +E  +YA + ++ + RT+    RE  PS  EI +   
Sbjct: 1054 LPHHPFLWLLRLHLKRNADS--RTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLL 1111

Query: 401  RQ------ELLCTVHCPGAGACAVAIDSHTTAGEVARELVGRLGLAR-SRNAFALYEQRG 453
            R            VH        V  D+ TT  E    L    G+ + +++ FAL+    
Sbjct: 1112 RNPYHHSLPFSIPVHFMNGIYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDP 1171

Query: 454  A---QERALAGGTLVADVLTRFENLAAEEAGLEDSPDSGWRLCLRLHGPLHPEGLSPDGH 510
            +    E  L G   + D+++++E  + E+   +       RL  +       +       
Sbjct: 1172 SGRDLEHCLQGNIKICDIISKWEQASKEQQPGKCEGTRTVRLTYKNRLYFSVQARGETDR 1231

Query: 511  ELPFLFEQAHALLLRGRPPPPDDTLRALAALRLQSLHRDFSPRVPLPRLDRLLPPPAPPR 570
            E   L  Q +  ++ G  P   D    +AAL  Q    DF                    
Sbjct: 1232 EKLLLMYQTNDQIINGLFPLNKDLALEMAALLSQVEIGDF-------------------- 1271

Query: 571  EDPPRPTPRPPPSAALLAGALWSPGLAKRRAERARRGGAGRTAGSIAREGGGGAGTAAAV 630
             + P  TP    +            + K   +R R G +      + +           +
Sbjct: 1272 -ERPFSTPAGHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQLRQLCQR----------L 1320

Query: 631  LGGWKRLRGMGRAEAMAAYLALAAQCPGFGA 661
               W  LRG   A+ +  YL +A + P FGA
Sbjct: 1321 STRWMALRGHSAADCVRIYLTVARKWPFFGA 1351


>gi|189083802 myosin VIIA isoform 2 [Homo sapiens]
          Length = 2175

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 79/296 (26%), Positives = 121/296 (40%), Gaps = 49/296 (16%)

Query: 298  PALRDELFLQLAKQTSGPAGPPGLPATQDPAALRY---WQLLT-CMSCTFRPGGAVRGHL 353
            PALRDE++ Q++KQ            T +P+   Y   W L++ C+ C F P      +L
Sbjct: 1165 PALRDEIYCQISKQ-----------LTHNPSKSSYARGWILVSLCVGC-FAPSEKFVKYL 1212

Query: 354  LGHLERTEQALPDSELAEYARFIRKALGRT---RGRELVPSLAEISALSQRQELLCTVHC 410
               +              YA +  + L RT     R   PS  E+ A   ++ ++  V  
Sbjct: 1213 RNFIHGGPPG--------YAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTF 1264

Query: 411  PGAGACAVAIDSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGT-LVADVL 469
                   +  DS TTA E+   L  ++ L + R  F+LY     +  +L  G+  V D +
Sbjct: 1265 MDGTTKTLLTDSATTAKELCNALADKISL-KDRFGFSLYIALFDKVSSLGSGSDHVMDAI 1323

Query: 470  TRFENLAAEEAGLEDSPDSGWRLCLR--LHGPLHPEGLSPDGHELPFLFEQAHALLLRG- 526
            ++ E  A E+   E   ++ WRL  R  +  P H    S D      +++Q    ++RG 
Sbjct: 1324 SQCEQYAKEQGAQE--RNAPWRLFFRKEVFTPWHSP--SEDNVATNLIYQQ----VVRGV 1375

Query: 527  -----RPPPPDDTLRALAALRLQSLHRDFSPRVPLPRLDRLLPPPAPPREDPPRPT 577
                 R    DD    LA L  Q    D+   + L RL  L+P   P RE  P  T
Sbjct: 1376 KFGEYRCEKEDD----LAELASQQYFVDYGSEMILERLLNLVPTYIPDREITPLKT 1427


>gi|189083798 myosin VIIA isoform 1 [Homo sapiens]
          Length = 2215

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 79/296 (26%), Positives = 121/296 (40%), Gaps = 49/296 (16%)

Query: 298  PALRDELFLQLAKQTSGPAGPPGLPATQDPAALRY---WQLLT-CMSCTFRPGGAVRGHL 353
            PALRDE++ Q++KQ            T +P+   Y   W L++ C+ C F P      +L
Sbjct: 1165 PALRDEIYCQISKQ-----------LTHNPSKSSYARGWILVSLCVGC-FAPSEKFVKYL 1212

Query: 354  LGHLERTEQALPDSELAEYARFIRKALGRT---RGRELVPSLAEISALSQRQELLCTVHC 410
               +              YA +  + L RT     R   PS  E+ A   ++ ++  V  
Sbjct: 1213 RNFIHGGPPG--------YAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTF 1264

Query: 411  PGAGACAVAIDSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGT-LVADVL 469
                   +  DS TTA E+   L  ++ L + R  F+LY     +  +L  G+  V D +
Sbjct: 1265 MDGTTKTLLTDSATTAKELCNALADKISL-KDRFGFSLYIALFDKVSSLGSGSDHVMDAI 1323

Query: 470  TRFENLAAEEAGLEDSPDSGWRLCLR--LHGPLHPEGLSPDGHELPFLFEQAHALLLRG- 526
            ++ E  A E+   E   ++ WRL  R  +  P H    S D      +++Q    ++RG 
Sbjct: 1324 SQCEQYAKEQGAQE--RNAPWRLFFRKEVFTPWHSP--SEDNVATNLIYQQ----VVRGV 1375

Query: 527  -----RPPPPDDTLRALAALRLQSLHRDFSPRVPLPRLDRLLPPPAPPREDPPRPT 577
                 R    DD    LA L  Q    D+   + L RL  L+P   P RE  P  T
Sbjct: 1376 KFGEYRCEKEDD----LAELASQQYFVDYGSEMILERLLNLVPTYIPDREITPLKT 1427


>gi|122937512 myosin VIIB [Homo sapiens]
          Length = 2116

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 60/236 (25%), Positives = 95/236 (40%), Gaps = 33/236 (13%)

Query: 298  PALRDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLT-CMSCTFRPGGAVRGHLLGH 356
            P+LRDE++ Q+ KQ S           +  +  R W LL+ C+ C F P      +LL  
Sbjct: 1104 PSLRDEIYCQICKQLS--------ENFKTSSLARGWILLSLCLGC-FPPSERFMKYLLNF 1154

Query: 357  LERTEQALPDSELAEYARFIRKALGRTRG---RELVPSLAEISALSQRQELLCTVHCPGA 413
            + +          A Y  F  + L RT     R   P+  E+ A+  ++ +   V     
Sbjct: 1155 IGQGP--------ATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVILATG 1206

Query: 414  GACAVAIDSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGG-TLVADVLTRF 472
             +  V +DS +T+ E+   +  + GL+     F+L      +  +L  G   + D + R 
Sbjct: 1207 ESLTVPVDSASTSREMCMHIAHKQGLS-DHLGFSLQVAVYDKFWSLGSGRDHMMDAIARC 1265

Query: 473  ENLAAEEAGLEDSPDSGWRLCLR--LHGPLHPEGLSPDGHELPFLFEQAHALLLRG 526
            E +A E    E    S WR+  R     P H      D  E P   E  +  +LRG
Sbjct: 1266 EQMAQERG--ESQRQSPWRIYFRKEFFTPWH------DSREDPVSTELIYRQVLRG 1313



 Score = 36.6 bits (83), Expect = 0.094
 Identities = 38/146 (26%), Positives = 64/146 (43%), Gaps = 17/146 (11%)

Query: 298  PALRDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHL 357
            PAL+DE++ Q+ KQ +          +   +  R WQLL   +  F P   +  H    +
Sbjct: 1704 PALQDEVYCQILKQLT--------HNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFI 1755

Query: 358  E--RTEQALPDSELAEYARFIRKALGRTRGRELVPSLAEISALSQRQELLC-TVHCPGAG 414
            +  R +   PD      +R I+K L RT  R+  P   E+ A  Q    +C  ++ P   
Sbjct: 1756 DTRRGKLLAPDC-----SRRIQKVL-RTGPRKQPPHQVEVEAAEQNVSRICHKIYFPNDT 1809

Query: 415  ACAVAIDSHTTAGEVARELVGRLGLA 440
            +  + + ++T   +V   +  RL LA
Sbjct: 1810 SEMLEVVANTRVRDVCDSIATRLQLA 1835


>gi|239754368 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 336

 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 52/166 (31%), Positives = 62/166 (37%), Gaps = 49/166 (29%)

Query: 551 SPRVPLPRLDRLLPPPA---PPREDPPRPTPRPP------PSAALLAGALW--------- 592
           SP+  + R  R LP      PP   P RPTPR        P AA   G  W         
Sbjct: 160 SPKARMERASRKLPSRVNSRPPHPAPTRPTPRVQGGFGREPRAAAGQGRGWLPPCRLRLQ 219

Query: 593 --------SPGLAKRRAERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAE 644
                    PG    R+ R+R  G+GR   S    G GG+G AAA       LRG     
Sbjct: 220 DSGPRRRPGPGPPALRSGRSR--GSGRPPDSAGAAGTGGSGWAAA-------LRGWPAPS 270

Query: 645 AMAAYLALAAQC--PGFGAARYDVLE------------LSTEPGRG 676
           + AA  AL  +C  P  G    ++LE            L  E GRG
Sbjct: 271 SFAASSALPEECLPPRRGCGWAELLEREAGGSDTGHLPLGNEGGRG 316


>gi|239748915 PREDICTED: hypothetical protein XP_002346855 [Homo
           sapiens]
          Length = 336

 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 52/166 (31%), Positives = 62/166 (37%), Gaps = 49/166 (29%)

Query: 551 SPRVPLPRLDRLLPPPA---PPREDPPRPTPRPP------PSAALLAGALW--------- 592
           SP+  + R  R LP      PP   P RPTPR        P AA   G  W         
Sbjct: 160 SPKARMERASRKLPSRVNSRPPHPAPTRPTPRVQGGFGREPRAAAGQGRGWLPPCRLRLQ 219

Query: 593 --------SPGLAKRRAERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAE 644
                    PG    R+ R+R  G+GR   S    G GG+G AAA       LRG     
Sbjct: 220 DSGPRRRPGPGPPALRSGRSR--GSGRPPDSAGAAGTGGSGWAAA-------LRGWPAPS 270

Query: 645 AMAAYLALAAQC--PGFGAARYDVLE------------LSTEPGRG 676
           + AA  AL  +C  P  G    ++LE            L  E GRG
Sbjct: 271 SFAASSALPEECLPPRRGCGWAELLEREAGGSDTGHLPLGNEGGRG 316


>gi|239742939 PREDICTED: hypothetical protein XP_002342693 [Homo
           sapiens]
          Length = 321

 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 52/166 (31%), Positives = 62/166 (37%), Gaps = 49/166 (29%)

Query: 551 SPRVPLPRLDRLLPPPA---PPREDPPRPTPRPP------PSAALLAGALW--------- 592
           SP+  + R  R LP      PP   P RPTPR        P AA   G  W         
Sbjct: 160 SPKARMERASRKLPSRVNSRPPHPAPTRPTPRVQGGFGREPRAAAGQGRGWLPPCRLRLQ 219

Query: 593 --------SPGLAKRRAERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAE 644
                    PG    R+ R+R  G+GR   S    G GG+G AAA       LRG     
Sbjct: 220 DSGPRRRPGPGPPALRSGRSR--GSGRPPDSAGAAGTGGSGWAAA-------LRGWPAPS 270

Query: 645 AMAAYLALAAQC--PGFGAARYDVLE------------LSTEPGRG 676
           + AA  AL  +C  P  G    ++LE            L  E GRG
Sbjct: 271 SFAASSALPEECLPPRRGCGWAELLEREAGGSDTGHLPLGNEGGRG 316


>gi|169213235 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 308

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 51/154 (33%), Positives = 58/154 (37%), Gaps = 28/154 (18%)

Query: 551 SPRVPLPRLDRLLPPPAPP-REDPPRPTPRPPPSAALLAGALWSPGLAKRRAE-RARRGG 608
           +P  PL R+    PPPAPP    P  P+    P A L  GA  SPG   RRA    R G 
Sbjct: 56  APGSPLYRVSA--PPPAPPPPPPPGGPSRSERPRAGLRPGAFVSPGPLGRRASCSGRAGS 113

Query: 609 AGR-----TAGSIAREGG---------------GGAGTAAAVLGGWKRLRGMGRAEAMAA 648
           AGR      A S A+ GG               G A    A  GG       GR+ A  A
Sbjct: 114 AGRLRCSAAALSAAQRGGPARAQVPPALRTFSPGPASPPRASPGGRPGSEARGRSGAECA 173

Query: 649 YLALAAQCP----GFGAARYDVLELSTEPGRGAP 678
                   P    G G+ R    +L   P RG P
Sbjct: 174 RRVPLHHGPPGASGVGSERDRKFQLHQTPARGPP 207


>gi|169212744 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 308

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 51/154 (33%), Positives = 58/154 (37%), Gaps = 28/154 (18%)

Query: 551 SPRVPLPRLDRLLPPPAPP-REDPPRPTPRPPPSAALLAGALWSPGLAKRRAE-RARRGG 608
           +P  PL R+    PPPAPP    P  P+    P A L  GA  SPG   RRA    R G 
Sbjct: 56  APGSPLYRVSA--PPPAPPPPPPPGGPSRSERPRAGLRPGAFVSPGPLGRRASCSGRAGS 113

Query: 609 AGR-----TAGSIAREGG---------------GGAGTAAAVLGGWKRLRGMGRAEAMAA 648
           AGR      A S A+ GG               G A    A  GG       GR+ A  A
Sbjct: 114 AGRLRCSAAALSAAQRGGPARAQVPPALRTFSPGPASPPRASPGGRPGSEARGRSGAECA 173

Query: 649 YLALAAQCP----GFGAARYDVLELSTEPGRGAP 678
                   P    G G+ R    +L   P RG P
Sbjct: 174 RRVPLHHGPPGASGVGSERDRKFQLHQTPARGPP 207


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 38/103 (36%), Positives = 42/103 (40%), Gaps = 25/103 (24%)

Query: 528 PPPPDDTLRALAALRLQSLHRDFSPRV------PL----PRLDRLLPP-PAPPREDPPRP 576
           PPPP     A+A L+ Q+    F P+V      PL    PRL R  PP PAP    P  P
Sbjct: 717 PPPPPQVTSAIATLQ-QAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPP 775

Query: 577 TPRPPPSA-------------ALLAGALWSPGLAKRRAERARR 606
            P  PP A              L A  L  P L  RR  RA R
Sbjct: 776 PPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASR 818



 Score = 37.7 bits (86), Expect = 0.042
 Identities = 26/69 (37%), Positives = 29/69 (42%), Gaps = 4/69 (5%)

Query: 564 PPPAPPREDPPRPTPRPPPSAALLAGALWSPGLAKRRAERARRGG-AGRTA---GSIARE 619
           PPPAPP++ PP P P  PP     A     P       E A  GG  GR      S  R 
Sbjct: 26  PPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEAADEGGPRGRLRSRDSSCGRP 85

Query: 620 GGGGAGTAA 628
           G  GA + A
Sbjct: 86  GTPGAASTA 94



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 27/79 (34%), Positives = 32/79 (40%), Gaps = 6/79 (7%)

Query: 552 PRVPLPRLDRLLPPPAPPREDPPRPTPRP---PPSAALLAGALWSPGLAKRRAERARRGG 608
           P  P P   +  PPP PP   PP P P P   PP A  L       G  + R  R+R   
Sbjct: 23  PPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEAADEGGPRGRL-RSRDSS 81

Query: 609 AGR--TAGSIAREGGGGAG 625
            GR  T G+ +   G   G
Sbjct: 82  CGRPGTPGAASTAKGSPNG 100


>gi|118402590 myosin XV [Homo sapiens]
          Length = 3530

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 47/192 (24%), Positives = 76/192 (39%), Gaps = 17/192 (8%)

Query: 290  VLQTCRDLPALRDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAV 349
            ++Q    +P LRDE+  QLA Q                 A R W LL      F P    
Sbjct: 2113 IVQKGLAVPELRDEILAQLANQVWHNHNAHN--------AERGWLLLAACLSGFAPSPCF 2164

Query: 350  RGHLLGHLERTEQALPDSELAEYARFIRKALGRTR------GRELVPSLAEISALSQRQE 403
              +LL  +    +   +   A     + +A+GR +       R L P+  E +A  ++  
Sbjct: 2165 NKYLLKFVSDYGR---NGFQAVCQHRLMQAMGRAQQQGSGAARTLPPTQLEWTATYEKAS 2221

Query: 404  LLCTVHCPGAGACAVAIDSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGT 463
            +   V C      +  + S +T  EVA +++   GLA     + +  + G Q   LAG  
Sbjct: 2222 MALDVGCFNGDQFSCPVHSWSTGEEVAGDILRHRGLADGWRGWTVAMKNGVQWAELAGHD 2281

Query: 464  LVADVLTRFENL 475
             V D+++  E L
Sbjct: 2282 YVLDLVSDLELL 2293



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 52/229 (22%), Positives = 93/229 (40%), Gaps = 26/229 (11%)

Query: 263  LREEAVRLFLALQALEG-----ARRPGPLMQGVLQTCRDLPALRDELFLQLAKQTSGPAG 317
            L + A  +FLA+    G      +    ++  +L+ C D   +RDE + Q+ KQ +    
Sbjct: 3067 LSKMATDMFLAVMRFMGDAPLKGQSDLDVLCNLLKLCGDHEVMRDECYCQVVKQITDNT- 3125

Query: 318  PPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQ--ALPDSELAEYARF 375
                 +++  +  R W+LL  ++        +  HL   L+   +   LP   +A+    
Sbjct: 3126 -----SSKQDSCQRGWRLLYIVTAYHSCSEVLHPHLTRFLQDVSRTPGLPFQGIAKACEQ 3180

Query: 376  IRKALGRTRGRELVPSLAEISAL-----SQRQELLCTVHCPGAGACAVAIDSHTTAGEVA 430
              +   R  GR  +PS  E+ A+     S+RQ  L     PG     + I + T A +V 
Sbjct: 3181 NLQKTLRFGGRLELPSSIELRAMLAGRSSKRQLFL----LPGGLERHLKIKTCTVALDVV 3236

Query: 431  RELVGRLGLARSR--NAFALY--EQRGAQERALAGGTLVADVLTRFENL 475
             E+   + L R    N + ++    RG     L+    + DV +  E +
Sbjct: 3237 EEICAEMALTRPEAFNEYVIFVVTNRGQHVCPLSRRAYILDVASEMEQV 3285



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 2/62 (3%)

Query: 661  AARYDVLELSTEPGRG--APQKLCLGLGAKAMSLSRPGETEPIHSVSYGHVAACQLMGPH 718
            AA  D L+L TEPGRG  A     +   A A  + R  E  P+ + S  H      + P+
Sbjct: 2951 AAAPDFLQLPTEPGRGRAAAVAAAVASAAAAQEVGRRREGPPVRARSADHGEDALALPPY 3010

Query: 719  TL 720
            T+
Sbjct: 3011 TM 3012



 Score = 31.2 bits (69), Expect = 3.9
 Identities = 17/36 (47%), Positives = 17/36 (47%), Gaps = 4/36 (11%)

Query: 555 PLPRL----DRLLPPPAPPREDPPRPTPRPPPSAAL 586
           P PR       LL PP PPR     P P PP S AL
Sbjct: 649 PAPRTLSHWSALLSPPVPPRPPSSGPPPAPPLSPAL 684


>gi|169164209 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 179

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 43/147 (29%), Positives = 53/147 (36%), Gaps = 24/147 (16%)

Query: 528 PPPPDDTLRALAALRLQSLHRDFSPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALL 587
           PPPPD                   P  P  R   +  PP+P R   P P+  P PS A  
Sbjct: 16  PPPPD------------------LPPTPTRRAPLIGCPPSPAR---PAPSASPSPSRA-- 52

Query: 588 AGALWSPGLAKRRAERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMA 647
           AG    P  A   + R+    A RT  ++    G G G A A+  G  R +   R     
Sbjct: 53  AGPFLPPSHAST-SSRSPPPRARRTEPAVPPSCGSGPGAAGALRMGLGRTQRAARVAVSR 111

Query: 648 AYLALAAQCPGFGAARYDVLELSTEPG 674
           A     A   G GA R   L L  + G
Sbjct: 112 ALAGTVAAAAGLGARRARRLHLRGQIG 138


>gi|239741571 PREDICTED: hypothetical protein XP_002342241 [Homo
           sapiens]
          Length = 179

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 43/147 (29%), Positives = 53/147 (36%), Gaps = 24/147 (16%)

Query: 528 PPPPDDTLRALAALRLQSLHRDFSPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALL 587
           PPPPD                   P  P  R   +  PP+P R   P P+  P PS A  
Sbjct: 16  PPPPD------------------LPPTPTRRAPLIGCPPSPAR---PAPSASPSPSRA-- 52

Query: 588 AGALWSPGLAKRRAERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMA 647
           AG    P  A   + R+    A RT  ++    G G G A A+  G  R +   R     
Sbjct: 53  AGPFLPPSHAST-SSRSPPPRARRTEPAVPPSCGSGPGAAGALRMGLGRTQRAARVAVSR 111

Query: 648 AYLALAAQCPGFGAARYDVLELSTEPG 674
           A     A   G GA R   L L  + G
Sbjct: 112 ALAGTVAAAAGLGARRARRLHLRGQIG 138


>gi|13994190 frizzled 8 [Homo sapiens]
          Length = 694

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 30/76 (39%), Positives = 32/76 (42%), Gaps = 4/76 (5%)

Query: 558 RLDRLLPPPAPPREDPPRPTPRPPPSAALLAGALWSPGLAKRRAERARRGGAGRTAGSIA 617
           R D     P+PPR  PP P    PPS    +G    PG         R GG G  A   A
Sbjct: 153 RTDLTTAAPSPPRRLPPPPPGEQPPSG---SGHGRPPGARPPHRGGGRGGGGGDAAAPPA 209

Query: 618 REGGGGAGTAAAVLGG 633
           R GGGG G A    GG
Sbjct: 210 R-GGGGGGKARPPGGG 224


>gi|139394646 iroquois homeobox protein 5 [Homo sapiens]
          Length = 483

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 56/202 (27%), Positives = 67/202 (33%), Gaps = 49/202 (24%)

Query: 478 EEAGLEDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRA 537
           E  G E    SG   C RL GP  P G   +G      F++          PP +  L A
Sbjct: 217 EAGGAEQKAASG---CERLQGPPTPAGKETEGSLSDSDFKE----------PPSEGRLDA 263

Query: 538 LAALRLQSLHRDFSPRVPLPRLDRLLPPPAP--------------PREDPPRP------- 576
           L     Q   R   P    P   RL   PAP                E PP P       
Sbjct: 264 L-----QGPPRTGGPSPAGPAAARLAEDPAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIH 318

Query: 577 -TPRPPPSAALLAGALWSPGLAKRRAERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWK 635
             P PPP A L    LWS       +++ + GG G          G  AG A        
Sbjct: 319 SPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGNEGSPCPPCPGPIAGQA-------- 370

Query: 636 RLRGMGRAEAMAAYLALAAQCP 657
            L G   + A A   + +AQCP
Sbjct: 371 -LGGSRASPAPAPSRSPSAQCP 391


>gi|46430491 scratch 2 protein [Homo sapiens]
          Length = 307

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 51/183 (27%), Positives = 68/183 (37%), Gaps = 24/183 (13%)

Query: 503 EGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAALRLQSLHRDFSPRVPLPRLDRL 562
           +G    G   P       A +L G   PP D   A   L   S   D  P + L   +  
Sbjct: 13  DGFQCSGVPAPTYHPLETAYVLPGARGPPGDNGYAPHRLPPSSYDADQKPGLELAPAEPA 72

Query: 563 LPPPAPPREDPPRPTPRPPPSAALLAG--------ALWSPGLAKRRAERARRGGAGRTAG 614
            PP AP     P  +P+   SA    G        ++ +  ++  R+ R R GG G   G
Sbjct: 73  YPPAAPEEYSDPE-SPQSSLSARYFRGEAAVTDSYSMDAFFISDGRSRRRRGGGGGDAGG 131

Query: 615 SIAREGGGG-AGTAAAVLGGWKR--LRGMGRAEAMAAYLA------------LAAQCPGF 659
           S    G GG AG A A  GG  R      G+  A ++ L+            LA +CP  
Sbjct: 132 SGDAGGAGGRAGRAGAQAGGGHRHACAECGKTYATSSNLSRHKQTHRSLDSQLARKCPTC 191

Query: 660 GAA 662
           G A
Sbjct: 192 GKA 194


>gi|36029914 valosin containing protein (p97)/p47 complex
           interacting protein 1 [Homo sapiens]
          Length = 1222

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 21/44 (47%), Positives = 23/44 (52%)

Query: 564 PPPAPPREDPPRPTPRPPPSAALLAGALWSPGLAKRRAERARRG 607
           PPP PP   PP P P  P + + LA A  S GL KRR  R   G
Sbjct: 4   PPPPPPPLPPPPPPPEAPQTPSSLASAAASGGLLKRRDRRILSG 47


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 36/108 (33%), Positives = 44/108 (40%), Gaps = 5/108 (4%)

Query: 483 EDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAALR 542
           E+SP S      RL  P     LSP   E P       + L    PPP D  +       
Sbjct: 586 EESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRL---SPPPEDSPMSPPPEES 642

Query: 543 LQSLHRDFSPRVPLPRLDRLLPPPAP-PREDPPRPTP-RPPPSAALLA 588
             S   + S   PLP + RL PPP   P   PP  +P  PPP A+ L+
Sbjct: 643 PMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLS 690



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 42/153 (27%), Positives = 55/153 (35%), Gaps = 32/153 (20%)

Query: 499  PLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAALRLQSLHRDFSPRVPL-- 556
            P HP+   P  +  P+       L  R +PPPP+    +  AL  +SL  D   RVP   
Sbjct: 2363 PSHPDIFRPGSYTDPYA---QPPLTPRPQPPPPE----SCCALPPRSLPSDPFSRVPASP 2415

Query: 557  -----------PR---LDRLLPPPAPPREDPPRPTPRPP--PSAALLAGALWSPGLAKRR 600
                       PR    +   P P  PR   P P  RPP  P +         P     +
Sbjct: 2416 QSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSR-------DPFAPLHK 2468

Query: 601  AERARRGGAGRTAGSIAREGGGGAGTAAAVLGG 633
              R +       AGS+A    G  G  AA+  G
Sbjct: 2469 PPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAG 2501



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 31/102 (30%), Positives = 40/102 (39%), Gaps = 25/102 (24%)

Query: 483 EDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAALR 542
           E+SP S      RL  P      SP   + P               PPP+D+L       
Sbjct: 676 EESPTSPPPEASRLSPPPEDSPTSPPPEDSP-------------ASPPPEDSL------- 715

Query: 543 LQSLHRDFSPRVPLPRLDRLLP----PPAPPREDPPRPTPRP 580
             SL  + SP +PLP   +L P    P   PR + P  +PRP
Sbjct: 716 -MSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRP 756



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 35/117 (29%), Positives = 44/117 (37%), Gaps = 23/117 (19%)

Query: 483 EDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAALR 542
           E+SP S      RL  P     +SP   E P              PPP    L  L  + 
Sbjct: 613 EESPLSPPPEASRLSPPPEDSPMSPPPEESPM------------SPPPEVSRLSPLPVVS 660

Query: 543 LQSLHRDFSPRVPLPRLDRLLPPP-----APPRED-----PPRPTP-RPPPSAALLA 588
             S   + SP  P P      PPP     +PP ED     PP  +P  PPP  +L++
Sbjct: 661 RLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMS 717



 Score = 33.1 bits (74), Expect = 1.0
 Identities = 35/112 (31%), Positives = 41/112 (36%), Gaps = 13/112 (11%)

Query: 478 EEAGLEDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRA 537
           EE+ L   P+S          PL    LSP     P     + AL     PPP    L  
Sbjct: 499 EESPLSPPPESS------PFSPLEESPLSPPEESPP-----SPALETPLSPPPEASPLSP 547

Query: 538 LAALRLQSLHRDFSPRVPLPRLDRLLPPPAP-PREDPPRPTP-RPPPSAALL 587
                  S   +  P  P P   RL PPP   P   PP  +P  PPP A+ L
Sbjct: 548 PFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRL 599



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 22/51 (43%), Positives = 25/51 (49%), Gaps = 6/51 (11%)

Query: 551  SPRVPLPRLDRLLPPPAPPREDPPRPTPRPP-----PSAALLAGALWSPGL 596
            SP   LP  +  LPP  P    P  PT  PP     P+AA LA  L+S GL
Sbjct: 4325 SPSSQLPT-EAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGL 4374



 Score = 31.6 bits (70), Expect = 3.0
 Identities = 26/78 (33%), Positives = 31/78 (39%), Gaps = 17/78 (21%)

Query: 528 PPPPDDTLRALAALRLQSLHRDFSPRVPLPRLDRLLPPP-------------APPREDPP 574
           PPP +     L      S   + SP  P P    L PPP             +PP E PP
Sbjct: 469 PPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPP 528

Query: 575 RP---TP-RPPPSAALLA 588
            P   TP  PPP A+ L+
Sbjct: 529 SPALETPLSPPPEASPLS 546


>gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo
            sapiens]
          Length = 1636

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 30/104 (28%), Positives = 43/104 (41%), Gaps = 9/104 (8%)

Query: 689  AMSLSRPGETEPIHS-VSYGHVAACQLMGPHTLALRV-GESQLLLQSPQVEEIMQLVNAY 746
            A+    PG  +P H  ++YG   + + MGP    L + G S     +P    +     + 
Sbjct: 1033 ALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLVPSPAPSP 1092

Query: 747  LANPSPERPCSSSSPPC-------QDLPDTSPPSQRPGLDEPQG 783
               P P RP ++  PPC        DL  +SP SQ  G   P G
Sbjct: 1093 GPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGG 1136


>gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]
          Length = 841

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 69/251 (27%), Positives = 89/251 (35%), Gaps = 27/251 (10%)

Query: 551 SPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALLA--------GALWSPGLAKRRAE 602
           S   P P   R   P   PR   P P P   P   LL         G+  +PG  +R A 
Sbjct: 96  STPTPSPVSRRSASPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAG 155

Query: 603 RARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKR--LRGMGRAE--AMAAYLALAAQCPG 658
           R   G  GR   + A E G     A A + G +   L G G  E  A  A LA    CP 
Sbjct: 156 RFEGGAEGRAQDADAPEPG---LQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPC 212

Query: 659 FGAARYDVLELSTEPGRGAPQKLCLGLGAKAMSLSRPGETEPIHSVSYGHVAACQLMGPH 718
                   LEL   P  G  +   +   A  +  SR   + P H  S GH A        
Sbjct: 213 VCHTTRPGLELRWVPVGGYEEVPRVPRRASPLRTSR---SRP-HPPSIGHPAVVL----- 263

Query: 719 TLALRVGESQL--LLQSPQVEEIMQLVNAYLANPSPERP-CSSSSPPCQDLPDTSPPSQR 775
           T      E +L  LL+ P+   + Q    +   P P+    S       D PD +P +  
Sbjct: 264 TSYRSTAERKLLPLLKPPKPTRVRQDATIFGDPPQPDLDLLSEDGIQTGDSPDEAPQNTP 323

Query: 776 PGLDEPQGQSG 786
           P   E + + G
Sbjct: 324 PATVEGREEEG 334


>gi|239751929 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 382

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 34/92 (36%), Positives = 38/92 (41%), Gaps = 14/92 (15%)

Query: 565 PPAPPRE--DPPRPTPRPPPSA---------ALLAGALWSPGLAKRRAERARRGGAGRTA 613
           PP PPR   DP  P+P P P A          L  G   SP L +  +   +R G G T 
Sbjct: 117 PPTPPRSGLDPAVPSPTPAPLARCRQTRAGLRLSTGGRLSPPLRRAASGEWKRPG-GLTQ 175

Query: 614 GSIAREGGGGAGTAAAVLGGWKRLRGMGRAEA 645
           G  A  G GGA        G  R RG GR  A
Sbjct: 176 GEFAGRGAGGARVTHR--PGRLRPRGRGRGRA 205


>gi|239746415 PREDICTED: hypothetical protein XP_002344217 [Homo
           sapiens]
          Length = 382

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 34/92 (36%), Positives = 38/92 (41%), Gaps = 14/92 (15%)

Query: 565 PPAPPRE--DPPRPTPRPPPSA---------ALLAGALWSPGLAKRRAERARRGGAGRTA 613
           PP PPR   DP  P+P P P A          L  G   SP L +  +   +R G G T 
Sbjct: 117 PPTPPRSGLDPAVPSPTPAPLARCRQTRAGLRLSTGGRLSPPLRRAASGEWKRPG-GLTQ 175

Query: 614 GSIAREGGGGAGTAAAVLGGWKRLRGMGRAEA 645
           G  A  G GGA        G  R RG GR  A
Sbjct: 176 GEFAGRGAGGARVTHR--PGRLRPRGRGRGRA 205


>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
          Length = 1612

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 35/114 (30%), Positives = 44/114 (38%), Gaps = 19/114 (16%)

Query: 544  QSLHRDFSPRVPLPR------LDRLLPPPAPPREDPPRPTP--RPPPSAALLA------- 588
            QS   D  P  PLP+      L+   PPP  P   P RP P  RPPP +   +       
Sbjct: 1121 QSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKE 1180

Query: 589  ----GALWSPGLAKRRAERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLR 638
                GA  SPG+A+R  E  +  G  R       +    AG A     G+   R
Sbjct: 1181 FGGIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTAR 1234


>gi|237757308 synaptojanin 1 isoform b [Homo sapiens]
          Length = 1350

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 35/114 (30%), Positives = 44/114 (38%), Gaps = 19/114 (16%)

Query: 544  QSLHRDFSPRVPLPR------LDRLLPPPAPPREDPPRPTP--RPPPSAALLA------- 588
            QS   D  P  PLP+      L+   PPP  P   P RP P  RPPP +   +       
Sbjct: 1121 QSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKE 1180

Query: 589  ----GALWSPGLAKRRAERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLR 638
                GA  SPG+A+R  E  +  G  R       +    AG A     G+   R
Sbjct: 1181 FGGIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTAR 1234


>gi|82546824 forkhead box K1 [Homo sapiens]
          Length = 733

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 32/98 (32%), Positives = 37/98 (37%), Gaps = 10/98 (10%)

Query: 532 DDTLRALAALRLQSLHRDFSPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALLAGAL 591
           D   RAL ALR                     PPPAP +  PP P P PPP   L  GA+
Sbjct: 7   DSGARALLALRSAPCSPVLCAAAAAAAFPAAAPPPAPAQPQPP-PGPPPPPPPPLPPGAI 65

Query: 592 WSPGLAKRRAERARRGGAGRTAGSIAREGGGGAGTAAA 629
              G +         GG+   +G  A  G   A  AAA
Sbjct: 66  AGAGSS---------GGSSGVSGDSAVAGAAPALVAAA 94


>gi|224465238 hypothetical protein LOC283999 [Homo sapiens]
          Length = 394

 Score = 39.7 bits (91), Expect = 0.011
 Identities = 43/145 (29%), Positives = 49/145 (33%), Gaps = 15/145 (10%)

Query: 552 PRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAAL------LAGALWSPGLAKRRAERAR 605
           PR+P PR  R    PA P   PP   P  P   A           L +PG   R+     
Sbjct: 157 PRLPAPRAPRRPRGPATPDPSPPAGRPHGPAGRAAPGRRPGCTAQLRAPGRRGRQRLLVH 216

Query: 606 RGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMAAYLAL------AAQCPGF 659
            GG GR            A  A   L   +R    G  + +   LA       AA  P  
Sbjct: 217 PGGGGRRQWQRLARARRAALLALGALAHLRRCPDTGGGQHLHQLLAPGLCGDGAAVWPAA 276

Query: 660 GAARYDVLELSTEPGRGAPQKLCLG 684
            A R   L L   PG G    LCLG
Sbjct: 277 HAGRPRQLRLVHGPGLGL---LCLG 298


>gi|239754991 PREDICTED: hypothetical protein isoform 1 [Homo
           sapiens]
          Length = 209

 Score = 39.7 bits (91), Expect = 0.011
 Identities = 37/95 (38%), Positives = 41/95 (43%), Gaps = 5/95 (5%)

Query: 544 QSLHRDFSPRV-PLPRLDRLLPP-PAPPREDPPRPTPRPPPSAALLAGALWSPGLAKRRA 601
           QS  R  +P V P P   R  P  PA PRE   R  P P PS    A A  SPGLA R +
Sbjct: 116 QSGWRLSTPAVGPRPAARRAAPSSPAVPREGQ-RAAPPPRPSGTFAASARLSPGLAGRGS 174

Query: 602 ERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKR 636
                  A    G +   G    G AAA  GG +R
Sbjct: 175 PARPGARASHPPGPVGVFGASSQGLAAA--GGPER 207


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,044,315
Number of Sequences: 37866
Number of extensions: 2438131
Number of successful extensions: 24162
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 171
Number of HSP's successfully gapped in prelim test: 479
Number of HSP's that attempted gapping in prelim test: 18362
Number of HSP's gapped (non-prelim): 4502
length of query: 793
length of database: 18,247,518
effective HSP length: 110
effective length of query: 683
effective length of database: 14,082,258
effective search space: 9618182214
effective search space used: 9618182214
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.