Guide to the Human Genome
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Search of human proteins with 40217617

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40217617 potassium channel tetramerisation domain containing
1 isoform a [Homo sapiens]
         (257 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|218505694 potassium channel tetramerisation domain containing...   525   e-149
gi|209969708 potassium channel tetramerisation domain containing...   525   e-149
gi|40217617 potassium channel tetramerisation domain containing ...   525   e-149
gi|194018443 potassium channel tetramerisation domain containing...   425   e-119
gi|194018441 potassium channel tetramerisation domain containing...   425   e-119
gi|194018439 potassium channel tetramerisation domain containing...   352   2e-97
gi|189571693 potassium channel tetramerisation domain containing...   110   2e-24
gi|189571691 potassium channel tetramerisation domain containing...   110   2e-24
gi|71143104 potassium channel tetramerisation domain containing ...   102   4e-22
gi|146198864 potassium channel tetramerisation domain containing...    88   6e-18
gi|40807368 potassium channel regulator isoform 2 [Homo sapiens]       76   3e-14
gi|27734697 potassium channel regulator isoform 1 [Homo sapiens]       76   3e-14
gi|19923973 potassium channel tetramerisation domain containing ...    72   5e-13
gi|55926200 potassium channel tetramerisation domain containing ...    70   2e-12
gi|38198663 potassium channel tetramerisation domain containing ...    69   3e-12
gi|155369221 potassium channel tetramerisation domain containing...    68   7e-12
gi|23308551 potassium channel tetramerisation domain containing ...    62   4e-10
gi|142356950 potassium channel tetramerisation domain containing...    61   8e-10
gi|51036594 potassium channel tetramerisation domain containing ...    58   9e-09
gi|13994353 potassium channel tetramerisation domain containing ...    57   2e-08
gi|45387953 potassium channel tetramerization domain containing ...    54   1e-07
gi|223005950 SH3KBP1 binding protein 1 [Homo sapiens]                  53   2e-07
gi|10863937 tumor necrosis factor, alpha-induced protein 1 [Homo...    52   4e-07
gi|30578412 potassium channel tetramerisation domain containing ...    51   1e-06
gi|169234778 potassium channel tetramerisation domain containing...    50   1e-06
gi|27436981 potassium voltage-gated channel, Shal-related subfam...    49   3e-06
gi|25952108 potassium voltage-gated channel delayed-rectifier pr...    49   4e-06
gi|53829365 potassium channel tetramerisation domain containing ...    49   4e-06
gi|9789987 potassium voltage-gated channel, Shal-related subfami...    47   1e-05
gi|46255026 potassium channel tetramerisation domain containing ...    47   2e-05

>gi|218505694 potassium channel tetramerisation domain containing 1
           isoform b [Homo sapiens]
          Length = 865

 Score =  525 bits (1352), Expect = e-149
 Identities = 257/257 (100%), Positives = 257/257 (100%)

Query: 1   MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF 60
           MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF
Sbjct: 609 MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF 668

Query: 61  DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM 120
           DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM
Sbjct: 669 DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM 728

Query: 121 LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN 180
           LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN
Sbjct: 729 LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN 788

Query: 181 AGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELR 240
           AGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELR
Sbjct: 789 AGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELR 848

Query: 241 RTPRVPSVIRIKQEPLD 257
           RTPRVPSVIRIKQEPLD
Sbjct: 849 RTPRVPSVIRIKQEPLD 865


>gi|209969708 potassium channel tetramerisation domain containing 1
           isoform a [Homo sapiens]
          Length = 257

 Score =  525 bits (1352), Expect = e-149
 Identities = 257/257 (100%), Positives = 257/257 (100%)

Query: 1   MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF 60
           MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF
Sbjct: 1   MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF 60

Query: 61  DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM 120
           DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM
Sbjct: 61  DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM 120

Query: 121 LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN 180
           LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN
Sbjct: 121 LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN 180

Query: 181 AGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELR 240
           AGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELR
Sbjct: 181 AGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELR 240

Query: 241 RTPRVPSVIRIKQEPLD 257
           RTPRVPSVIRIKQEPLD
Sbjct: 241 RTPRVPSVIRIKQEPLD 257


>gi|40217617 potassium channel tetramerisation domain containing 1
           isoform a [Homo sapiens]
          Length = 257

 Score =  525 bits (1352), Expect = e-149
 Identities = 257/257 (100%), Positives = 257/257 (100%)

Query: 1   MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF 60
           MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF
Sbjct: 1   MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF 60

Query: 61  DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM 120
           DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM
Sbjct: 61  DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM 120

Query: 121 LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN 180
           LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN
Sbjct: 121 LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN 180

Query: 181 AGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELR 240
           AGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELR
Sbjct: 181 AGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELR 240

Query: 241 RTPRVPSVIRIKQEPLD 257
           RTPRVPSVIRIKQEPLD
Sbjct: 241 RTPRVPSVIRIKQEPLD 257


>gi|194018443 potassium channel tetramerisation domain containing 15
           isoform 2 [Homo sapiens]
          Length = 283

 Score =  425 bits (1093), Expect = e-119
 Identities = 205/257 (79%), Positives = 228/257 (88%)

Query: 1   MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF 60
           MSR  +TRSP SPL  QGIP PAQLTKSNAPVHIDVGGHMYTSSLATLTKYP+SRI RLF
Sbjct: 27  MSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLF 86

Query: 61  DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM 120
           +GTEPIVLDSLKQHYFIDRDG++FRY+L+FLRTSKLL+PDDFKD++LLYEEA+Y+QLQPM
Sbjct: 87  NGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPM 146

Query: 121 LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN 180
           + E+ERW+Q++E  R SR C+CLVVRV PDLGERI LSG+K+LIEEVFPE GDVMCNSVN
Sbjct: 147 VRELERWQQEQEQRRRSRACDCLVVRVTPDLGERIALSGEKALIEEVFPETGDVMCNSVN 206

Query: 181 AGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELR 240
           AGWN D THVIRFPLNGYC LNSVQVLERL QRGF +  SCGGGVDSSQFSEYVL RE R
Sbjct: 207 AGWNQDPTHVIRFPLNGYCRLNSVQVLERLFQRGFSVAASCGGGVDSSQFSEYVLCREER 266

Query: 241 RTPRVPSVIRIKQEPLD 257
           R    P+ +RIKQEPLD
Sbjct: 267 RPQPTPTAVRIKQEPLD 283


>gi|194018441 potassium channel tetramerisation domain containing 15
           isoform 2 [Homo sapiens]
          Length = 283

 Score =  425 bits (1093), Expect = e-119
 Identities = 205/257 (79%), Positives = 228/257 (88%)

Query: 1   MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF 60
           MSR  +TRSP SPL  QGIP PAQLTKSNAPVHIDVGGHMYTSSLATLTKYP+SRI RLF
Sbjct: 27  MSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLF 86

Query: 61  DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM 120
           +GTEPIVLDSLKQHYFIDRDG++FRY+L+FLRTSKLL+PDDFKD++LLYEEA+Y+QLQPM
Sbjct: 87  NGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPM 146

Query: 121 LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN 180
           + E+ERW+Q++E  R SR C+CLVVRV PDLGERI LSG+K+LIEEVFPE GDVMCNSVN
Sbjct: 147 VRELERWQQEQEQRRRSRACDCLVVRVTPDLGERIALSGEKALIEEVFPETGDVMCNSVN 206

Query: 181 AGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELR 240
           AGWN D THVIRFPLNGYC LNSVQVLERL QRGF +  SCGGGVDSSQFSEYVL RE R
Sbjct: 207 AGWNQDPTHVIRFPLNGYCRLNSVQVLERLFQRGFSVAASCGGGVDSSQFSEYVLCREER 266

Query: 241 RTPRVPSVIRIKQEPLD 257
           R    P+ +RIKQEPLD
Sbjct: 267 RPQPTPTAVRIKQEPLD 283


>gi|194018439 potassium channel tetramerisation domain containing 15
           isoform 1 [Homo sapiens]
          Length = 234

 Score =  352 bits (903), Expect = 2e-97
 Identities = 167/205 (81%), Positives = 187/205 (91%)

Query: 1   MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF 60
           MSR  +TRSP SPL  QGIP PAQLTKSNAPVHIDVGGHMYTSSLATLTKYP+SRI RLF
Sbjct: 27  MSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLF 86

Query: 61  DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM 120
           +GTEPIVLDSLKQHYFIDRDG++FRY+L+FLRTSKLL+PDDFKD++LLYEEA+Y+QLQPM
Sbjct: 87  NGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPM 146

Query: 121 LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN 180
           + E+ERW+Q++E  R SR C+CLVVRV PDLGERI LSG+K+LIEEVFPE GDVMCNSVN
Sbjct: 147 VRELERWQQEQEQRRRSRACDCLVVRVTPDLGERIALSGEKALIEEVFPETGDVMCNSVN 206

Query: 181 AGWNHDSTHVIRFPLNGYCHLNSVQ 205
           AGWN D THVIRFPLNGYC LNSVQ
Sbjct: 207 AGWNQDPTHVIRFPLNGYCRLNSVQ 231


>gi|189571693 potassium channel tetramerisation domain containing 6
           [Homo sapiens]
          Length = 237

 Score =  110 bits (274), Expect = 2e-24
 Identities = 49/91 (53%), Positives = 72/91 (79%), Gaps = 1/91 (1%)

Query: 31  PVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNF 90
           PV ++VGGH+YT+SL TLT+YP+S +G +F G  P   D  + +YFIDRDG +FRY+LNF
Sbjct: 13  PVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDP-QGNYFIDRDGPLFRYVLNF 71

Query: 91  LRTSKLLIPDDFKDYTLLYEEAKYFQLQPML 121
           LRTS+L +P DFK++ LL +EA ++Q++P++
Sbjct: 72  LRTSELTLPLDFKEFDLLRKEADFYQIEPLI 102


>gi|189571691 potassium channel tetramerisation domain containing 6
           [Homo sapiens]
          Length = 237

 Score =  110 bits (274), Expect = 2e-24
 Identities = 49/91 (53%), Positives = 72/91 (79%), Gaps = 1/91 (1%)

Query: 31  PVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNF 90
           PV ++VGGH+YT+SL TLT+YP+S +G +F G  P   D  + +YFIDRDG +FRY+LNF
Sbjct: 13  PVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDP-QGNYFIDRDGPLFRYVLNF 71

Query: 91  LRTSKLLIPDDFKDYTLLYEEAKYFQLQPML 121
           LRTS+L +P DFK++ LL +EA ++Q++P++
Sbjct: 72  LRTSELTLPLDFKEFDLLRKEADFYQIEPLI 102


>gi|71143104 potassium channel tetramerisation domain containing 21
           [Homo sapiens]
          Length = 260

 Score =  102 bits (253), Expect = 4e-22
 Identities = 48/91 (52%), Positives = 70/91 (76%), Gaps = 1/91 (1%)

Query: 31  PVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNF 90
           P+ ++VGG +YT+SLATLT +P+S +G +F G  P   DS + + FIDRDG++FRYILNF
Sbjct: 4   PITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDS-QGNCFIDRDGKVFRYILNF 62

Query: 91  LRTSKLLIPDDFKDYTLLYEEAKYFQLQPML 121
           LRTS L +P+DF++  LL  EA ++Q+QP++
Sbjct: 63  LRTSHLDLPEDFQEMGLLRREADFYQVQPLI 93


>gi|146198864 potassium channel tetramerisation domain containing 4
           [Homo sapiens]
          Length = 259

 Score = 88.2 bits (217), Expect = 6e-18
 Identities = 43/103 (41%), Positives = 73/103 (70%), Gaps = 2/103 (1%)

Query: 34  IDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRT 93
           ++VGG++Y +   TLTKYP++ +  + +G      D+   HYFIDRDG +FR++LNFLR 
Sbjct: 37  LNVGGYLYITQKQTLTKYPDTFLEGIVNGKILCPFDA-DGHYFIDRDGLLFRHVLNFLRN 95

Query: 94  SKLLIPDDFKDYTLLYEEAKYFQLQPMLLEME-RWKQDRETGR 135
            +LL+P+ F++  LL +EA++FQL+ +  E++ RW++++ T R
Sbjct: 96  GELLLPEGFRENQLLAQEAEFFQLKGLAEEVKSRWEKEQLTPR 138


>gi|40807368 potassium channel regulator isoform 2 [Homo sapiens]
          Length = 229

 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 34/90 (37%), Positives = 60/90 (66%), Gaps = 1/90 (1%)

Query: 32  VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFL 91
           V ++VGG ++T+  +T+ ++P SR+ R+ DG +      +    F+DRDG +F +IL+FL
Sbjct: 7   VTLNVGGKIFTTRFSTIKQFPASRLARMLDGRDQ-EFKMVGGQIFVDRDGDLFSFILDFL 65

Query: 92  RTSKLLIPDDFKDYTLLYEEAKYFQLQPML 121
           RT +LL+P +F DY  L  EA +++L+ ++
Sbjct: 66  RTHQLLLPTEFSDYLRLQREALFYELRSLV 95


>gi|27734697 potassium channel regulator isoform 1 [Homo sapiens]
          Length = 272

 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 34/90 (37%), Positives = 60/90 (66%), Gaps = 1/90 (1%)

Query: 32  VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFL 91
           V ++VGG ++T+  +T+ ++P SR+ R+ DG +      +    F+DRDG +F +IL+FL
Sbjct: 7   VTLNVGGKIFTTRFSTIKQFPASRLARMLDGRDQ-EFKMVGGQIFVDRDGDLFSFILDFL 65

Query: 92  RTSKLLIPDDFKDYTLLYEEAKYFQLQPML 121
           RT +LL+P +F DY  L  EA +++L+ ++
Sbjct: 66  RTHQLLLPTEFSDYLRLQREALFYELRSLV 95


>gi|19923973 potassium channel tetramerisation domain containing 12
           [Homo sapiens]
          Length = 325

 Score = 72.0 bits (175), Expect = 5e-13
 Identities = 36/92 (39%), Positives = 60/92 (65%), Gaps = 3/92 (3%)

Query: 32  VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEP--IVLDSLKQHYFIDRDGQMFRYILN 89
           V ++VGG +Y +   T+   P+S + R+F   +P  +  DS K  +F+DRDG +FRYIL+
Sbjct: 36  VELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDS-KGRFFLDRDGFLFRYILD 94

Query: 90  FLRTSKLLIPDDFKDYTLLYEEAKYFQLQPML 121
           +LR  +L++PD F + + L  EA+YF+L  ++
Sbjct: 95  YLRDLQLVLPDYFPERSRLQREAEYFELPELV 126


>gi|55926200 potassium channel tetramerisation domain containing 16
           [Homo sapiens]
          Length = 428

 Score = 69.7 bits (169), Expect = 2e-12
 Identities = 70/245 (28%), Positives = 109/245 (44%), Gaps = 52/245 (21%)

Query: 32  VHIDVGGHMYTSSLATLTKYPESRIGRLF----DGTEPIVLDSLKQHYFIDRDGQMFRYI 87
           V ++VGG +Y +  +TL   P S + ++F    D    +  DS K  +FIDRDG +FRYI
Sbjct: 27  VELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDTANDLAKDS-KGRFFIDRDGFLFRYI 85

Query: 88  LNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM--LLEMERWKQ-----------DRETG 134
           L++LR  ++++PD F +   L  EA+YFQL  +  LL  +  KQ           D   G
Sbjct: 86  LDYLRDRQVVLPDHFPEKGRLKREAEYFQLPDLVKLLTPDEIKQSPDEFCHSDFEDASQG 145

Query: 135 RFSRPCE--------------CLVVRVAPDLGE------------RITLSGDKSLIEEVF 168
             +R C                +  R +  LG             RI + G  SL +EVF
Sbjct: 146 SDTRICPPSSLLPADRKWGFITVGYRGSCTLGREGQADAKFRRVPRILVCGRISLAKEVF 205

Query: 169 PEIGDVMCNSVNAGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSS 228
            E  +   +   A   + S   ++F      HL   +  + L + GF +V +C   V +S
Sbjct: 206 GETLNESRDPDRAPERYTSRFYLKFK-----HLE--RAFDMLSECGFHMV-ACNSSVTAS 257

Query: 229 QFSEY 233
             ++Y
Sbjct: 258 FINQY 262


>gi|38198663 potassium channel tetramerisation domain containing 8
           [Homo sapiens]
          Length = 473

 Score = 69.3 bits (168), Expect = 3e-12
 Identities = 38/126 (30%), Positives = 67/126 (53%), Gaps = 10/126 (7%)

Query: 5   LITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTE 64
           +++ S +   +    P P   +     V ++VGG +Y +  +TL   P+S +  +F  + 
Sbjct: 19  MVSSSSSPGASAAAAPGPCAPSPFPEVVELNVGGQVYVTKHSTLLSVPDSTLASMFSPSS 78

Query: 65  P---------IVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYF 115
           P         +  DS +  +FIDRDG +FRY+L++LR  +L +P+ F +   L  EA+YF
Sbjct: 79  PRGGARRRGELPRDS-RARFFIDRDGFLFRYVLDYLRDKQLALPEHFPEKERLLREAEYF 137

Query: 116 QLQPML 121
           QL  ++
Sbjct: 138 QLTDLV 143


>gi|155369221 potassium channel tetramerisation domain containing 19
           [Homo sapiens]
          Length = 926

 Score = 68.2 bits (165), Expect = 7e-12
 Identities = 39/109 (35%), Positives = 59/109 (54%), Gaps = 13/109 (11%)

Query: 32  VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFL 91
           + + VG H Y ++L TL KYPE     L    + +   +  Q   I  DGQMFR+ILNFL
Sbjct: 398 IKVYVGSHWYATTLQTLLKYPE-----LLSNPQRVYWITYGQTLLIHGDGQMFRHILNFL 452

Query: 92  RTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLE-------MERWKQDRET 133
           R  KL +P +FK++ L  +E + + + P L E        + W Q++E+
Sbjct: 453 RLGKLFLPSEFKEWPLFCQEVEEYHI-PSLSEALAQCEAYKSWTQEKES 500



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 37/116 (31%), Positives = 59/116 (50%), Gaps = 6/116 (5%)

Query: 33  HIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLR 92
           H +VGG  ++   + L+++P+S + +        +  S  Q  FIDRDG  FR++  +L 
Sbjct: 16  HFNVGGWHFSVPRSKLSQFPDSLLWK----EASALTSSESQRLFIDRDGSTFRHVHYYLY 71

Query: 93  TSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRETGRFSRPCECLVVRVA 148
           TSKL       +  LLYE+A   QL P+L  ++  K+ +   R  RP +  V   A
Sbjct: 72  TSKLSF-SSCAELNLLYEQALGLQLMPLLQTLDNLKEGKHHLRV-RPADLPVAERA 125



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 19/44 (43%), Positives = 30/44 (68%), Gaps = 1/44 (2%)

Query: 84  FRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERW 127
           FR+I+NFLR+ K+L+PD+F +  +L  E +  ++ P L E  RW
Sbjct: 211 FRFIVNFLRSQKILLPDNFSNIDVLEAEVEILEI-PALTEAVRW 253



 Score = 33.5 bits (75), Expect = 0.19
 Identities = 20/66 (30%), Positives = 37/66 (56%), Gaps = 7/66 (10%)

Query: 40  MYTSSLATLTKYPESRIGRL-FDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLI 98
           +YT +L  L KYP+S +G+L  + T    LD      +I  +G +F+++ N+L T +L +
Sbjct: 286 LYTMALGLLVKYPDSALGQLRIEST----LDG--SRLYITGNGVLFQHVKNWLGTCRLPL 339

Query: 99  PDDFKD 104
            +   +
Sbjct: 340 TETISE 345


>gi|23308551 potassium channel tetramerisation domain containing 7
           [Homo sapiens]
          Length = 289

 Score = 62.4 bits (150), Expect = 4e-10
 Identities = 40/117 (34%), Positives = 65/117 (55%), Gaps = 5/117 (4%)

Query: 10  PASPLNNQ-GIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVL 68
           PA+P   Q G   P    +    V +++GG  +T+ L+TL  Y ++ +  +F G   I  
Sbjct: 30  PATPTATQAGHALPLLPQEFPEVVPLNIGGAHFTTRLSTLRCYEDTMLAAMFSGRHYIPT 89

Query: 69  DSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEME 125
           DS +  YFIDRDG  F  +LNFLR+  L   +  +    +Y+EA+Y+ + P+L ++E
Sbjct: 90  DS-EGRYFIDRDGTHFGDVLNFLRSGDLPPRERVR---AVYKEAQYYAIGPLLEQLE 142


>gi|142356950 potassium channel tetramerisation domain containing 14
           [Homo sapiens]
          Length = 255

 Score = 61.2 bits (147), Expect = 8e-10
 Identities = 40/132 (30%), Positives = 72/132 (54%), Gaps = 14/132 (10%)

Query: 1   MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF 60
           + RP+   +  +PL     P P + T S   V ++VGG  +T++L TL K+P S++  +F
Sbjct: 7   VERPVGRMTSQTPLPQS--PRPRRPTMSTV-VELNVGGEFHTTTLGTLRKFPGSKLAEMF 63

Query: 61  DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKL---LIPDDFKDYTLLYEEAKYFQL 117
                   D+ +  +FIDR    FR IL++LRT ++    IP+       +Y EA+++++
Sbjct: 64  SSLAKASTDA-EGRFFIDRPSTYFRPILDYLRTGQVPTQHIPE-------VYREAQFYEI 115

Query: 118 QPMLLEMERWKQ 129
           +P++  +E   Q
Sbjct: 116 KPLVKLLEDMPQ 127


>gi|51036594 potassium channel tetramerisation domain containing 11
           [Homo sapiens]
          Length = 232

 Score = 57.8 bits (138), Expect = 9e-09
 Identities = 25/48 (52%), Positives = 36/48 (75%)

Query: 74  HYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPML 121
           HYFIDRDG+ FR+ILNFLR  +L +P  + +  LL  EA ++Q++P+L
Sbjct: 23  HYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALLRAEADFYQIRPLL 70


>gi|13994353 potassium channel tetramerisation domain containing 10
           [Homo sapiens]
          Length = 313

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 34/106 (32%), Positives = 63/106 (59%), Gaps = 2/106 (1%)

Query: 28  SNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYI 87
           S+  V ++VGG +Y +++ TLTK  ++ +  +F G   ++ DS +    IDR G+ F  I
Sbjct: 30  SSKYVKLNVGGALYYTTMQTLTKQ-DTMLKAMFSGRMEVLTDS-EGWILIDRCGKHFGTI 87

Query: 88  LNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRET 133
           LN+LR   + +P+  ++   L  EAKY+ +Q ++ E +   Q+++T
Sbjct: 88  LNYLRDGAVPLPESRREIEELLAEAKYYLVQGLVEECQAALQNKDT 133


>gi|45387953 potassium channel tetramerization domain containing 18
           [Homo sapiens]
          Length = 426

 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 29/84 (34%), Positives = 50/84 (59%), Gaps = 2/84 (2%)

Query: 32  VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFL 91
           + ++VGG +YT+   +L ++ +S +  +F G  P+  D       IDRDG++F+Y+L++L
Sbjct: 14  LRLNVGGCIYTARRESLCRFKDSMLASMFSGRFPLKTDE-SGACVIDRDGRLFKYLLDYL 72

Query: 92  RTSKLLIPDDFKDYTLLYEEAKYF 115
              ++ IP D +    L EEA YF
Sbjct: 73  H-GEVQIPTDEQTRIALQEEADYF 95


>gi|223005950 SH3KBP1 binding protein 1 [Homo sapiens]
          Length = 707

 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 42/118 (35%), Positives = 63/118 (53%), Gaps = 8/118 (6%)

Query: 21  TPAQLTKSNAP----VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYF 76
           T A+   S  P    +H++VGG  +++S  TLT  P+S    L  G    + D      F
Sbjct: 6   TAAEGVPSRGPPGEVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDETGA-IF 64

Query: 77  IDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEME-RWKQDRET 133
           IDRD  +F  ILNFLRT K L P      +LL+ EA+++ L P++  ++ R + DR +
Sbjct: 65  IDRDPTVFAPILNFLRT-KELDPRGVHGSSLLH-EAQFYGLTPLVRRLQLREELDRSS 120


>gi|10863937 tumor necrosis factor, alpha-induced protein 1 [Homo
           sapiens]
          Length = 316

 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 35/140 (25%), Positives = 74/140 (52%), Gaps = 4/140 (2%)

Query: 29  NAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYIL 88
           N  V ++VGG +Y +++  LT++ ++ +  +F G   ++ D  +    IDR G+ F  IL
Sbjct: 27  NKYVQLNVGGSLYYTTVRALTRH-DTMLKAMFSGRMEVLTDK-EGWILIDRCGKHFGTIL 84

Query: 89  NFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRETGRFSRPCECLVVRVA 148
           N+LR   + +P + ++   L  EAKY+ +Q ++   +   QD++   +   C   ++   
Sbjct: 85  NYLRDDTITLPQNRQEIKELMAEAKYYLIQGLVNMCQSALQDKKDS-YQPVCNIPIITSL 143

Query: 149 PDLGERITLSGDKSLIEEVF 168
            +  ER+  S  K +++ ++
Sbjct: 144 KE-EERLIESSTKPVVKLLY 162


>gi|30578412 potassium channel tetramerisation domain containing 13
           [Homo sapiens]
          Length = 329

 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 33/110 (30%), Positives = 63/110 (57%), Gaps = 3/110 (2%)

Query: 25  LTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMF 84
           LT ++  V ++VGG ++ ++L TLT   ++ +  +F G   ++ D+      IDR G+ F
Sbjct: 36  LTPNSKYVKLNVGGSLHYTTLRTLTGQ-DTMLKAMFSGRVEVLTDA-GGWVLIDRSGRHF 93

Query: 85  RYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEME-RWKQDRET 133
             ILN+LR   + +P+  ++   L  EA+Y+ +Q ++ + +   +Q RET
Sbjct: 94  GTILNYLRDGSVPLPESTRELGELLGEARYYLVQGLIEDCQLALQQKRET 143


>gi|169234778 potassium channel tetramerisation domain containing 17
           [Homo sapiens]
          Length = 297

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 31/90 (34%), Positives = 50/90 (55%), Gaps = 1/90 (1%)

Query: 32  VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFL 91
           V ++VGG ++ ++  TL +  +S + RL  G E          Y IDRD   F  ILNFL
Sbjct: 33  VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFL 92

Query: 92  RTSKLLIPDDFKDYTLLYEEAKYFQLQPML 121
           R  KL++  D  +  +L EEA+++ + P++
Sbjct: 93  RHGKLVLDKDMAEEGVL-EEAEFYNIGPLI 121


>gi|27436981 potassium voltage-gated channel, Shal-related
           subfamily, member 1 [Homo sapiens]
          Length = 647

 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 32/112 (28%), Positives = 55/112 (49%), Gaps = 6/112 (5%)

Query: 13  PLNNQGIPTP--AQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDS 70
           PL  Q +P     + ++ +  + ++V G  + +   TL +YP++ +G      +    D+
Sbjct: 21  PLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLG---SSEKEFFYDA 77

Query: 71  LKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLL 122
               YF DRD  MFR++LNF RT +L  P   +      EE  ++ L P L+
Sbjct: 78  DSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQ-ECIQAFDEELAFYGLVPELV 128


>gi|25952108 potassium voltage-gated channel delayed-rectifier
           protein S3 [Homo sapiens]
          Length = 491

 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 26/99 (26%), Positives = 56/99 (56%), Gaps = 8/99 (8%)

Query: 32  VHIDVGGHMYTSSLATLTKYPESRIGRLFD-GTEPIVLDSLKQH------YFIDRDGQMF 84
           V+++VGG   +   +TL ++P +R+G+L    +E  +L+    +      Y+ DR+  +F
Sbjct: 17  VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLF 76

Query: 85  RYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLE 123
           RY+LNF  T KL + ++   ++   +E +Y+ +  + ++
Sbjct: 77  RYVLNFYYTGKLHVMEELCVFSFC-QEIEYWGINELFID 114


>gi|53829365 potassium channel tetramerisation domain containing 2
           [Homo sapiens]
          Length = 263

 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 35/104 (33%), Positives = 58/104 (55%), Gaps = 5/104 (4%)

Query: 32  VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQH---YFIDRDGQMFRYIL 88
           V ++VGG  + ++  TL + P+S + RL    +P  LDS K     Y IDRD   F  IL
Sbjct: 74  VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDP-ELDSDKDETGAYLIDRDPTYFGPIL 132

Query: 89  NFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRE 132
           N+LR  KL+I  +  +  +L EEA+++ +  ++  ++   +D E
Sbjct: 133 NYLRHGKLIITKELAEEGVL-EEAEFYNIASLVRLVKERIRDNE 175


>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
           member 2 [Homo sapiens]
          Length = 630

 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 33/113 (29%), Positives = 55/113 (48%), Gaps = 7/113 (6%)

Query: 13  PLNNQGIPTPAQLTKS---NAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLD 69
           P+ +  +P P +  +    +A + ++V G  + +   TL +YP++ +G            
Sbjct: 21  PVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLG---SSERDFFYH 77

Query: 70  SLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLL 122
              Q YF DRD  +FR+ILNF RT KL  P   +  +   EE  +F L P ++
Sbjct: 78  PETQQYFFDRDPDIFRHILNFYRTGKLHYP-RHECISAYDEELAFFGLIPEII 129


>gi|46255026 potassium channel tetramerisation domain containing 3
           [Homo sapiens]
          Length = 815

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 34/102 (33%), Positives = 51/102 (50%), Gaps = 7/102 (6%)

Query: 22  PAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDG 81
           PA    S   V ++VGG  +++S  TL   P+S    L  G    + D      FIDRD 
Sbjct: 10  PAAAAGSGEIVQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGA-IFIDRDP 68

Query: 82  QMFRYILNFLRTSKLLIPDDFKDYTL--LYEEAKYFQLQPML 121
             F  ILNFLRT +L    D +  ++  L  EA+++ + P++
Sbjct: 69  AAFAPILNFLRTKEL----DLRGVSINVLRHEAEFYGITPLV 106


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,088,889
Number of Sequences: 37866
Number of extensions: 442496
Number of successful extensions: 1126
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 1038
Number of HSP's gapped (non-prelim): 77
length of query: 257
length of database: 18,247,518
effective HSP length: 100
effective length of query: 157
effective length of database: 14,460,918
effective search space: 2270364126
effective search space used: 2270364126
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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