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Search of human proteins with 38788243
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38788243 myosin regulatory light chain interacting protein
[Homo sapiens]
(445 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38788243 myosin regulatory light chain interacting protein [H... 894 0.0
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 131 1e-30
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 129 7e-30
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 129 7e-30
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 127 2e-29
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 125 8e-29
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 125 8e-29
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 125 1e-28
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 125 1e-28
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 125 1e-28
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 124 2e-28
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 124 2e-28
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 122 7e-28
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 122 7e-28
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 121 1e-27
gi|117500790 FERM domain containing 3 [Homo sapiens] 121 1e-27
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 120 2e-27
gi|4506467 radixin [Homo sapiens] 120 2e-27
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 119 7e-27
gi|4505257 moesin [Homo sapiens] 117 3e-26
gi|161702986 ezrin [Homo sapiens] 115 6e-26
gi|21614499 ezrin [Homo sapiens] 115 6e-26
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 113 4e-25
gi|34916000 FERM domain containing 7 [Homo sapiens] 110 3e-24
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 108 7e-24
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 107 2e-23
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 107 2e-23
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 107 2e-23
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 107 2e-23
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 100 3e-21
>gi|38788243 myosin regulatory light chain interacting protein [Homo
sapiens]
Length = 445
Score = 894 bits (2311), Expect = 0.0
Identities = 445/445 (100%), Positives = 445/445 (100%)
Query: 1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRN 60
MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRN
Sbjct: 1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRN 60
Query: 61 RISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELS 120
RISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELS
Sbjct: 61 RISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELS 120
Query: 121 ALLAQTKFGDYNQNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVS 180
ALLAQTKFGDYNQNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVS
Sbjct: 121 ALLAQTKFGDYNQNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVS 180
Query: 181 AMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLT 240
AMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLT
Sbjct: 181 AMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLT 240
Query: 241 VTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLF 300
VTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLF
Sbjct: 241 VTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLF 300
Query: 301 LNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNC 360
LNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNC
Sbjct: 301 LNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNC 360
Query: 361 SSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPV 420
SSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPV
Sbjct: 361 SSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPV 420
Query: 421 CRSRVEHVQHVYLPTHTSLLNLTVI 445
CRSRVEHVQHVYLPTHTSLLNLTVI
Sbjct: 421 CRSRVEHVQHVYLPTHTSLLNLTVI 445
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 131 bits (329), Expect = 1e-30
Identities = 86/284 (30%), Positives = 139/284 (48%), Gaps = 7/284 (2%)
Query: 1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGES-LWLNLR 59
++C + D + +V G+ L+ V + L + E DYFGLQ ++ WL+
Sbjct: 29 VVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPN 88
Query: 60 NRISQQMDGLAPYRLKLRVKFFV-EPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVE 118
I +Q+ +PY L RVKFFV +P+ + +E TR+ +FL IK+ +L G L C A
Sbjct: 89 KPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAAL 148
Query: 119 LSALLAQTKFGDYNQ--NTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVL 176
L++ Q++ GDY+Q N + Y + I H++ G S A AE+ L
Sbjct: 149 LASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYL 208
Query: 177 QIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKN 236
+E YG+E+H RD +++IGV GI I K+ +N + + + K
Sbjct: 209 NTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVR-MNTFPWLKIVKISFKCKQ 267
Query: 237 VYLTVTKE--SGNSIVLLFKMISTRAASGLYRAITETHAFYRCD 278
++ + KE +L F M++ RA L++A E H F+R D
Sbjct: 268 FFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLD 311
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 129 bits (323), Expect = 7e-30
Identities = 81/284 (28%), Positives = 139/284 (48%), Gaps = 11/284 (3%)
Query: 1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGES-LWLNLR 59
++C + D V+ +V + G+ L+ V LG+ E +YFGLQ +S WL
Sbjct: 29 VICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEAS 88
Query: 60 NRISQQMDGLAPYRLKLRVKFFV-EPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVE 118
I +Q+ G P L RV+FF+ +P+ + QEQTRH++FL +K + G L C AV
Sbjct: 89 KAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVV 148
Query: 119 LSALLAQTKFGDYNQNTAKYNY--EELCAKELSSATLNSIVAKHKELEGTSQASAEYQVL 176
L++ Q+ FGDYN + Y + + + L + + H++ G Q+ AE +
Sbjct: 149 LASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYI 208
Query: 177 QIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKN 236
I ++ YG+E HS RD L+IG+ G+++ + I YP V + S K
Sbjct: 209 NIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYR---KYICTSFYPWVNILKISFKR 265
Query: 237 ----VYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYR 276
++ + ++ F M++ R+ L+++ E H F++
Sbjct: 266 KKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQ 309
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 129 bits (323), Expect = 7e-30
Identities = 81/284 (28%), Positives = 139/284 (48%), Gaps = 11/284 (3%)
Query: 1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGES-LWLNLR 59
++C + D V+ +V + G+ L+ V LG+ E +YFGLQ +S WL
Sbjct: 29 VICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEAS 88
Query: 60 NRISQQMDGLAPYRLKLRVKFFV-EPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVE 118
I +Q+ G P L RV+FF+ +P+ + QEQTRH++FL +K + G L C AV
Sbjct: 89 KAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVV 148
Query: 119 LSALLAQTKFGDYNQNTAKYNY--EELCAKELSSATLNSIVAKHKELEGTSQASAEYQVL 176
L++ Q+ FGDYN + Y + + + L + + H++ G Q+ AE +
Sbjct: 149 LASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYI 208
Query: 177 QIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKN 236
I ++ YG+E HS RD L+IG+ G+++ + I YP V + S K
Sbjct: 209 NIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYR---KYICTSFYPWVNILKISFKR 265
Query: 237 ----VYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYR 276
++ + ++ F M++ R+ L+++ E H F++
Sbjct: 266 KKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQ 309
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 127 bits (320), Expect = 2e-29
Identities = 83/285 (29%), Positives = 145/285 (50%), Gaps = 16/285 (5%)
Query: 3 CYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRI 62
C V+ D + V++ KA G++ +Q+ L +IE DYFGL+F S + WL+ I
Sbjct: 45 CRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSI 104
Query: 63 SQQMDGLAPYRLKLRVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSA 121
+Q+ +PY L LRVKF+ EP+ + +E TR++F L +K+ +L+G L C + AV+L+A
Sbjct: 105 KKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQLAA 164
Query: 122 LLAQTKFGDYN------QNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQV 175
Q + GDY+ + +++ + + +E+ A I K KE G + A AE
Sbjct: 165 YNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELA----IFEKWKEYRGQTPAQAETNY 220
Query: 176 LQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGK 235
L +E YG++ H V+ +G +G+ P G+ + + D + I +P +
Sbjct: 221 LNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGD-TKIGLFFWPKITRLDFKKN 279
Query: 236 NVYLTVTKESG----NSIVLLFKMISTRAASGLYRAITETHAFYR 276
+ L V ++ +F++ +A L++ E HAF+R
Sbjct: 280 KLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFR 324
>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
1 [Homo sapiens]
Length = 518
Score = 125 bits (314), Expect = 8e-29
Identities = 88/289 (30%), Positives = 138/289 (47%), Gaps = 14/289 (4%)
Query: 1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRN 60
+ C V D + V++ A G+D +Q+ L ++E DYFGLQF S + WL+
Sbjct: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
Query: 61 RISQQMDGLAPYRLKLRVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVEL 119
I +QM Y L RVK++ EP+ + +E TR++F L ++ +L+G L C E AVEL
Sbjct: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
Query: 120 SALLAQTKFGDYN--QNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQ 177
+AL Q + G+ ++T + E + A I + KE G S A AE L
Sbjct: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264
Query: 178 IVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIA---YPVVQMATQSG 234
+E YG++ H VR +G + +G+ P GI I F N+I +P +
Sbjct: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILI----FEGANKIGLFFWPKITKMDFKK 320
Query: 235 KNVYLTVTKESG----NSIVLLFKMISTRAASGLYRAITETHAFYRCDT 279
+ L V ++ +F++ S R L++ E HAF+R T
Sbjct: 321 SKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRT 369
>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
2 [Homo sapiens]
Length = 900
Score = 125 bits (314), Expect = 8e-29
Identities = 88/289 (30%), Positives = 138/289 (47%), Gaps = 14/289 (4%)
Query: 1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRN 60
+ C V D + V++ A G+D +Q+ L ++E DYFGLQF S + WL+
Sbjct: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
Query: 61 RISQQMDGLAPYRLKLRVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVEL 119
I +QM Y L RVK++ EP+ + +E TR++F L ++ +L+G L C E AVEL
Sbjct: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
Query: 120 SALLAQTKFGDYN--QNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQ 177
+AL Q + G+ ++T + E + A I + KE G S A AE L
Sbjct: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264
Query: 178 IVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIA---YPVVQMATQSG 234
+E YG++ H VR +G + +G+ P GI I F N+I +P +
Sbjct: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILI----FEGANKIGLFFWPKITKMDFKK 320
Query: 235 KNVYLTVTKESG----NSIVLLFKMISTRAASGLYRAITETHAFYRCDT 279
+ L V ++ +F++ S R L++ E HAF+R T
Sbjct: 321 SKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRT 369
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 125 bits (313), Expect = 1e-28
Identities = 83/283 (29%), Positives = 133/283 (46%), Gaps = 15/283 (5%)
Query: 3 CYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRI 62
C VT D ++E A G+ ++VC L ++E DYFGL F S + WL+ I
Sbjct: 220 CKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEI 279
Query: 63 SQQMDGLAPYRLKLRVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSA 121
+Q+ L P+ VKF+ +P + ++ TR+ L +++ + +G L CS L +
Sbjct: 280 KRQLRNL-PWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGS 338
Query: 122 LLAQTKFGDYNQ------NTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQV 175
Q + GDY+ + +++ + KEL + HK G S A A+ Q
Sbjct: 339 YTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELE----EKVAELHKTHRGLSPAQADSQF 394
Query: 176 LQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGK 235
L+ + YG++ H +DSEG + +GV G+ I KD INR A+P + +
Sbjct: 395 LENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLR-INRFAWPKILKISYKRS 453
Query: 236 NVYLTVTKESGNSI--VLLFKMISTRAASGLYRAITETHAFYR 276
N Y+ V + FK+ + RAA L++ E H FYR
Sbjct: 454 NFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYR 496
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 125 bits (313), Expect = 1e-28
Identities = 83/283 (29%), Positives = 133/283 (46%), Gaps = 15/283 (5%)
Query: 3 CYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRI 62
C VT D ++E A G+ ++VC L ++E DYFGL F S + WL+ I
Sbjct: 220 CKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEI 279
Query: 63 SQQMDGLAPYRLKLRVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSA 121
+Q+ L P+ VKF+ +P + ++ TR+ L +++ + +G L CS L +
Sbjct: 280 KRQLRNL-PWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGS 338
Query: 122 LLAQTKFGDYNQ------NTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQV 175
Q + GDY+ + +++ + KEL + HK G S A A+ Q
Sbjct: 339 YTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELE----EKVAELHKTHRGLSPAQADSQF 394
Query: 176 LQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGK 235
L+ + YG++ H +DSEG + +GV G+ I KD INR A+P + +
Sbjct: 395 LENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLR-INRFAWPKILKISYKRS 453
Query: 236 NVYLTVTKESGNSI--VLLFKMISTRAASGLYRAITETHAFYR 276
N Y+ V + FK+ + RAA L++ E H FYR
Sbjct: 454 NFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYR 496
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 125 bits (313), Expect = 1e-28
Identities = 83/283 (29%), Positives = 133/283 (46%), Gaps = 15/283 (5%)
Query: 3 CYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRI 62
C VT D ++E A G+ ++VC L ++E DYFGL F S + WL+ I
Sbjct: 220 CKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEI 279
Query: 63 SQQMDGLAPYRLKLRVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSA 121
+Q+ L P+ VKF+ +P + ++ TR+ L +++ + +G L CS L +
Sbjct: 280 KRQLRNL-PWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGS 338
Query: 122 LLAQTKFGDYNQ------NTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQV 175
Q + GDY+ + +++ + KEL + HK G S A A+ Q
Sbjct: 339 YTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELE----EKVAELHKTHRGLSPAQADSQF 394
Query: 176 LQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGK 235
L+ + YG++ H +DSEG + +GV G+ I KD INR A+P + +
Sbjct: 395 LENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLR-INRFAWPKILKISYKRS 453
Query: 236 NVYLTVTKESGNSI--VLLFKMISTRAASGLYRAITETHAFYR 276
N Y+ V + FK+ + RAA L++ E H FYR
Sbjct: 454 NFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYR 496
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 124 bits (310), Expect = 2e-28
Identities = 77/281 (27%), Positives = 135/281 (48%), Gaps = 7/281 (2%)
Query: 1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRN 60
M C V+ D + E VE A G+D L +VC L ++E DYFGL + WL+
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 61 RISQQMDGLAPYRLKLRVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVEL 119
I +Q+ G+ P+ VKF+ +P + ++ TR+ L +++ ++AG L CS L
Sbjct: 61 EIKKQVRGV-PWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
Query: 120 SALLAQTKFGDYNQNTAKYNY--EELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQ 177
+ Q++ GDY+ +Y + A + ++ HK + A A+ + L+
Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179
Query: 178 IVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNV 237
+ YG++ H +D EG +++GV G+ + KD INR +P V + +
Sbjct: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLR-INRFPWPKVLKISYKRSSF 238
Query: 238 YLTVT--KESGNSIVLLFKMISTRAASGLYRAITETHAFYR 276
++ + ++ + FK+ S RAA L++ E H F+R
Sbjct: 239 FIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFR 279
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 124 bits (310), Expect = 2e-28
Identities = 77/281 (27%), Positives = 135/281 (48%), Gaps = 7/281 (2%)
Query: 1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRN 60
M C V+ D + E VE A G+D L +VC L ++E DYFGL + WL+
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 61 RISQQMDGLAPYRLKLRVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVEL 119
I +Q+ G+ P+ VKF+ +P + ++ TR+ L +++ ++AG L CS L
Sbjct: 61 EIKKQVRGV-PWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
Query: 120 SALLAQTKFGDYNQNTAKYNY--EELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQ 177
+ Q++ GDY+ +Y + A + ++ HK + A A+ + L+
Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179
Query: 178 IVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNV 237
+ YG++ H +D EG +++GV G+ + KD INR +P V + +
Sbjct: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLR-INRFPWPKVLKISYKRSSF 238
Query: 238 YLTVT--KESGNSIVLLFKMISTRAASGLYRAITETHAFYR 276
++ + ++ + FK+ S RAA L++ E H F+R
Sbjct: 239 FIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFR 279
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 122 bits (306), Expect = 7e-28
Identities = 79/280 (28%), Positives = 131/280 (46%), Gaps = 7/280 (2%)
Query: 2 LCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNR 61
+C VT DA E EVE G+ + VC L ++E DYFGL F + + WL+
Sbjct: 36 ICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKE 95
Query: 62 ISQQMDGLAPYRLKLRVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELS 120
I +Q+ +P+ VKF+ +P + ++ TR+ L ++ ++ G L CS L
Sbjct: 96 IKKQIRS-SPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLG 154
Query: 121 ALLAQTKFGDYN--QNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQI 178
+ Q + GDY+ ++ Y E A + I+ HK G + AE L+
Sbjct: 155 SYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLEN 214
Query: 179 VSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVY 238
+ YG++ H +DSEG +++GV G+ I +D INR A+P + + N Y
Sbjct: 215 AKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLR-INRFAWPKILKISYKRSNFY 273
Query: 239 LTVTKESGNSI--VLLFKMISTRAASGLYRAITETHAFYR 276
+ + + FK+ + R+A L++ E H F+R
Sbjct: 274 IKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFR 313
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 122 bits (306), Expect = 7e-28
Identities = 79/280 (28%), Positives = 131/280 (46%), Gaps = 7/280 (2%)
Query: 2 LCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNR 61
+C VT DA E EVE G+ + VC L ++E DYFGL F + + WL+
Sbjct: 98 ICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKE 157
Query: 62 ISQQMDGLAPYRLKLRVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELS 120
I +Q+ +P+ VKF+ +P + ++ TR+ L ++ ++ G L CS L
Sbjct: 158 IKKQIRS-SPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLG 216
Query: 121 ALLAQTKFGDYN--QNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQI 178
+ Q + GDY+ ++ Y E A + I+ HK G + AE L+
Sbjct: 217 SYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLEN 276
Query: 179 VSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVY 238
+ YG++ H +DSEG +++GV G+ I +D INR A+P + + N Y
Sbjct: 277 AKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLR-INRFAWPKILKISYKRSNFY 335
Query: 239 LTVTKESGNSI--VLLFKMISTRAASGLYRAITETHAFYR 276
+ + + FK+ + R+A L++ E H F+R
Sbjct: 336 IKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFR 375
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 121 bits (304), Expect = 1e-27
Identities = 77/281 (27%), Positives = 137/281 (48%), Gaps = 7/281 (2%)
Query: 1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRN 60
M C V D +VE ++ G+ ++VC L ++E DYFGL + ++ + WL+
Sbjct: 110 MQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAK 169
Query: 61 RISQQMDGLAPYRLKLRVKFFV-EPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVEL 119
I +Q+ A + VKF+ +P + ++ TR+ L +++ +++G L CS L
Sbjct: 170 EIKKQVRSGA-WHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALL 228
Query: 120 SALLAQTKFGDYNQNTAKYNY--EELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQ 177
+ Q++ GDY+ + +Y E A + + ++ HK G + A AE L+
Sbjct: 229 GSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLE 288
Query: 178 IVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNV 237
+ YG++ H +DSEG ++++GV G+ I +D INR A+P V + N
Sbjct: 289 NAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLR-INRFAWPKVLKISYKRNNF 347
Query: 238 YLTVTKESGNSI--VLLFKMISTRAASGLYRAITETHAFYR 276
Y+ + + FK+ + RAA L++ E H F+R
Sbjct: 348 YIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFR 388
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 121 bits (304), Expect = 1e-27
Identities = 83/281 (29%), Positives = 133/281 (47%), Gaps = 8/281 (2%)
Query: 1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRN 60
M C + D + ++ + G+ ++ +C ++E DYFG+++ + + WL
Sbjct: 32 MRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNK 91
Query: 61 RISQQMDGLAPYRLKLRVKFFV-EPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVEL 119
I +QM PY + RVKF+ EP I +E TR++ +L IK + G LLCS A L
Sbjct: 92 SIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYL 151
Query: 120 SALLAQTKFGDYNQNTAKYNY---EELCAKELSSATLNSIVAKHK-ELEGTSQASAEYQV 175
A + Q + GDY+ + NY E+ K+ S IV HK EL G S AE+ +
Sbjct: 152 GACIVQAELGDYDPDEHPENYISEFEIFPKQ-SQKLERKIVEIHKNELRGQSPPVAEFNL 210
Query: 176 LQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGK 235
L +E YG++ H +DS G +G G + + + I+ I +P V GK
Sbjct: 211 LLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGN-KRIHLIKWPDVCKLKFEGK 269
Query: 236 NVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYR 276
Y+ T++ +L F + A L++ E AFY+
Sbjct: 270 TFYVIGTQKE-KKAMLAFHTSTPAACKHLWKCGVENQAFYK 309
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 120 bits (302), Expect = 2e-27
Identities = 79/264 (29%), Positives = 133/264 (50%), Gaps = 4/264 (1%)
Query: 16 EVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLK 75
EV +A G+ L+ VC L ++E DYFGL+F K ++WL+L I +Q+ +K
Sbjct: 55 EVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVK 114
Query: 76 LRVKFFVEPHLILQEQ-TRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGDYNQN 134
VKFF H LQE+ TR++F L +K+ L G L C+ A L + + Q++ GD+++
Sbjct: 115 FVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEA 174
Query: 135 TAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGIEWHSVRD 194
+ + + A + IV H G + A +++Q+L+I +E YGI H +D
Sbjct: 175 LDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKD 234
Query: 195 SEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSI--VLL 252
EG K+ + V GI + + F+ IN + V+ + K + + ++ ++ L
Sbjct: 235 REGTKINLAVANTGILVFQ-GFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLE 293
Query: 253 FKMISTRAASGLYRAITETHAFYR 276
F M S ++ E HAF+R
Sbjct: 294 FLMASRDFCKSFWKICVEHHAFFR 317
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 120 bits (302), Expect = 2e-27
Identities = 77/234 (32%), Positives = 122/234 (52%), Gaps = 14/234 (5%)
Query: 5 VTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQ 64
VT DA L E ++ G+ +QV + +G+ EV +FGLQ+ SKG S WL L +++Q
Sbjct: 9 VTTMDAEL-EFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQ 67
Query: 65 Q-MDGLAPYRLKLRVKFFVEP--HLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSA 121
Q + P + K R KFF E ++QE T+ +FFL +KEA+L + C PE AV L++
Sbjct: 68 QDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLAS 127
Query: 122 LLAQTKFGDYNQNTAKYNY----EELCAKELSSATLNS------IVAKHKELEGTSQASA 171
Q K+GDYN+ K Y L + L L I H+E G + +
Sbjct: 128 YAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDS 187
Query: 172 EYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYP 225
+ L+I +E YG+ + +++ +G +L +GV G++I + D +I +P
Sbjct: 188 MMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 119 bits (297), Expect = 7e-27
Identities = 94/365 (25%), Positives = 167/365 (45%), Gaps = 32/365 (8%)
Query: 17 VEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKL 76
++ A G+ + +C L ++E DYFG++F + WL + +Q+ P+ +
Sbjct: 33 IQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVKQLRSQPPFTMCF 92
Query: 77 RVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGDYN--Q 133
RVKF+ +P + +E TR++ FL IK L G LLC A L+A + Q + GDY+ +
Sbjct: 93 RVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYILQAEIGDYDSGK 152
Query: 134 NTAKYNYEELCAKELSSATLNSIVAKHK-ELEGTSQASAEYQVLQIVSAMENYGIEWHSV 192
+ Y+ + + S I HK EL G + A++E L+ +E YG++ H
Sbjct: 153 HPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQTLETYGVDPHPC 212
Query: 193 RDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLL 252
+D G + P G + + + ++ I + V GK YL V+++ I+L
Sbjct: 213 KDVSGNAAFLAFTPFGFVVLQGN-KRVHFIKWNEVTKLKFEGKTFYLYVSQKEEKKIILT 271
Query: 253 FKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYV 312
+ + A L++ E AFY+ + + + S +LF G ++
Sbjct: 272 YFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSS--------NLFFK-----GSRFR 318
Query: 313 FDIKRTSKEVYDHARR------ALYNAGVVDLVSRNNQSPSHSPLKSS-----ESSMNCS 361
+ R +KEV + + + ++ AG+V SR+ S +H P SS +++ S
Sbjct: 319 YS-GRVAKEVMESSAKIKREPPEIHRAGMVP--SRSCPSITHGPRLSSVPRTRRRAVHIS 375
Query: 362 SCEGL 366
EGL
Sbjct: 376 IMEGL 380
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 117 bits (292), Expect = 3e-26
Identities = 73/234 (31%), Positives = 124/234 (52%), Gaps = 14/234 (5%)
Query: 5 VTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRIS- 63
VT DA L E ++ G+ +QV + +G+ EV +FGLQ+ +KG S WL L +++
Sbjct: 9 VTTMDAEL-EFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTA 67
Query: 64 QQMDGLAPYRLKLRVKFFVEP--HLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSA 121
Q + +P K R KF+ E ++Q+ T+ +FFL +KE +L + C PE AV L++
Sbjct: 68 QDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLAS 127
Query: 122 LLAQTKFGDYNQNTAKYNY----EELCAKELSSATLNS------IVAKHKELEGTSQASA 171
Q+K+GD+N+ K Y + L + L LN I H+E G + A
Sbjct: 128 YAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDA 187
Query: 172 EYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYP 225
+ L+I +E YG+ + S+++ +G +L +GV G++I + + +I +P
Sbjct: 188 VLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 115 bits (289), Expect = 6e-26
Identities = 74/234 (31%), Positives = 119/234 (50%), Gaps = 14/234 (5%)
Query: 5 VTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRIS- 63
VT DA L E ++ G+ +QV + +G+ EV YFGL + +KG WL L ++S
Sbjct: 9 VTTMDAEL-EFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSA 67
Query: 64 QQMDGLAPYRLKLRVKFFVEP--HLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSA 121
Q++ P + K R KF+ E ++Q+ T+ +FFL +KE +L+ + C PE AV L +
Sbjct: 68 QEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGS 127
Query: 122 LLAQTKFGDYNQNTAKYNY---EELCAKELSSATL-------NSIVAKHKELEGTSQASA 171
Q KFGDYN+ K Y E L + + + I H E G + +A
Sbjct: 128 YAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNA 187
Query: 172 EYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYP 225
+ L+I +E YGI + +++ +G L +GV G++I + D +I +P
Sbjct: 188 MLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 115 bits (289), Expect = 6e-26
Identities = 74/234 (31%), Positives = 119/234 (50%), Gaps = 14/234 (5%)
Query: 5 VTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRIS- 63
VT DA L E ++ G+ +QV + +G+ EV YFGL + +KG WL L ++S
Sbjct: 9 VTTMDAEL-EFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSA 67
Query: 64 QQMDGLAPYRLKLRVKFFVEP--HLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSA 121
Q++ P + K R KF+ E ++Q+ T+ +FFL +KE +L+ + C PE AV L +
Sbjct: 68 QEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGS 127
Query: 122 LLAQTKFGDYNQNTAKYNY---EELCAKELSSATL-------NSIVAKHKELEGTSQASA 171
Q KFGDYN+ K Y E L + + + I H E G + +A
Sbjct: 128 YAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNA 187
Query: 172 EYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYP 225
+ L+I +E YGI + +++ +G L +GV G++I + D +I +P
Sbjct: 188 MLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 113 bits (282), Expect = 4e-25
Identities = 79/271 (29%), Positives = 134/271 (49%), Gaps = 11/271 (4%)
Query: 13 MEV-EVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAP 71
ME+ ++E K +G+ L QV +RL ++E DYFG++F ++ +WL I +Q+
Sbjct: 55 MEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKN 114
Query: 72 YRLKLRVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGD 130
L+L VKFF +P + +E TR++F L +K LL L C+ A L++ L Q++ GD
Sbjct: 115 VVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGD 174
Query: 131 YNQNTAKYNYEELCAKEL---SSATLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGI 187
Y++ + E L E L I+ H++ G + A +++QVL+I +E YGI
Sbjct: 175 YDETLDR---EHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGI 231
Query: 188 EWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGN 247
+H D EG K+ + V G+ + + + IN + V+ + K + + E
Sbjct: 232 RFHMASDREGTKIQLAVSHMGVLVFQGT-TKINTFNWSKVRKLSFKRKRFLIKLHPEVHG 290
Query: 248 SI--VLLFKMISTRAASGLYRAITETHAFYR 276
L F + S ++ E H F+R
Sbjct: 291 PYQDTLEFLLGSRDECKNFWKICVEYHTFFR 321
>gi|34916000 FERM domain containing 7 [Homo sapiens]
Length = 714
Score = 110 bits (275), Expect = 3e-24
Identities = 73/266 (27%), Positives = 128/266 (48%), Gaps = 10/266 (3%)
Query: 17 VEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKL 76
V+ K++G+ N C L + E +YFGL+F G ++WL L I++Q+ K
Sbjct: 18 VDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQVKNPKEIVFKF 77
Query: 77 RVKFF-VEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGDYNQNT 135
VKFF V+P + +E TR++F L IK+ L G L CS + + + Q++ GD+++ T
Sbjct: 78 MVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQSELGDFHEET 137
Query: 136 AKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGIEWHSVRDS 195
+ + + I+ H++ G S A ++ +L I ++ YGI H D
Sbjct: 138 DRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDIARKLDMYGIRPHPASDG 197
Query: 196 EGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLL--- 252
EG ++ + V G+ + + + + IN + ++ + K+ + K N +VL
Sbjct: 198 EGMQIHLAVAHMGVLVLRGN-TKINTFNWAKIRKLSFKRKHFLI---KLHANILVLCKDT 253
Query: 253 --FKMISTRAASGLYRAITETHAFYR 276
F M S A ++ E HAF+R
Sbjct: 254 LEFTMASRDACKAFWKTCVEYHAFFR 279
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 108 bits (271), Expect = 7e-24
Identities = 69/266 (25%), Positives = 123/266 (46%), Gaps = 7/266 (2%)
Query: 17 VEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGL---APYR 73
++ G L+ V + ++E+DYFGL++ ++ WL+ +++ + + PY
Sbjct: 32 IKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAEHKELINTGPPYT 91
Query: 74 LKLRVKFFVE-PHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGDYN 132
L +KF+ E P + +E TR+ FFL +K+ +L G L C A +L A Q++ GDY+
Sbjct: 92 LYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYAIQSELGDYD 151
Query: 133 --QNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGIEWH 190
++TA Y E + +I HK L G + AE L+ ++E YG++ H
Sbjct: 152 PYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSEAELNYLRTAKSLEMYGVDLH 211
Query: 191 SVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIV 250
V + +G+ P G+ + K+ + + +P + L V + N
Sbjct: 212 PVYGENKSEYFLGLTPVGVVVYKNK-KQVGKYFWPRITKVHFKETQFELRVLGKDCNETS 270
Query: 251 LLFKMISTRAASGLYRAITETHAFYR 276
F+ S A L++ E H F+R
Sbjct: 271 FFFEARSKTACKHLWKCSVEHHTFFR 296
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 107 bits (267), Expect = 2e-23
Identities = 70/223 (31%), Positives = 114/223 (51%), Gaps = 18/223 (8%)
Query: 13 MEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRI-SQQMDGLAP 71
ME E K G+D + VCR LG+ E +FGLQ+T K WL + ++ + P
Sbjct: 33 MEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKMDKKVLDHDVSKEEP 91
Query: 72 YRLKLRVKFFVE--PHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFG 129
KF+ E ++QE T+H+FFL +K+ +L + C PE +V L++ Q K+G
Sbjct: 92 VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYG 151
Query: 130 DYNQNTAKYNY---EELCAKELSSATL-------NSIVAKHKELEGTSQASAEYQVLQIV 179
DY+ + K + EEL K + + I A + E G ++ AE + L+I
Sbjct: 152 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 211
Query: 180 SAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRI 222
+E YG+ + ++R+ +G +LL+GV G+ I + P NR+
Sbjct: 212 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHI----YDPENRL 250
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 107 bits (267), Expect = 2e-23
Identities = 70/223 (31%), Positives = 114/223 (51%), Gaps = 18/223 (8%)
Query: 13 MEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRI-SQQMDGLAP 71
ME E K G+D + VCR LG+ E +FGLQ+T K WL + ++ + P
Sbjct: 33 MEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKMDKKVLDHDVSKEEP 91
Query: 72 YRLKLRVKFFVE--PHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFG 129
KF+ E ++QE T+H+FFL +K+ +L + C PE +V L++ Q K+G
Sbjct: 92 VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYG 151
Query: 130 DYNQNTAKYNY---EELCAKELSSATL-------NSIVAKHKELEGTSQASAEYQVLQIV 179
DY+ + K + EEL K + + I A + E G ++ AE + L+I
Sbjct: 152 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 211
Query: 180 SAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRI 222
+E YG+ + ++R+ +G +LL+GV G+ I + P NR+
Sbjct: 212 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHI----YDPENRL 250
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 107 bits (267), Expect = 2e-23
Identities = 70/223 (31%), Positives = 114/223 (51%), Gaps = 18/223 (8%)
Query: 13 MEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRI-SQQMDGLAP 71
ME E K G+D + VCR LG+ E +FGLQ+T K WL + ++ + P
Sbjct: 33 MEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKMDKKVLDHDVSKEEP 91
Query: 72 YRLKLRVKFFVE--PHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFG 129
KF+ E ++QE T+H+FFL +K+ +L + C PE +V L++ Q K+G
Sbjct: 92 VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYG 151
Query: 130 DYNQNTAKYNY---EELCAKELSSATL-------NSIVAKHKELEGTSQASAEYQVLQIV 179
DY+ + K + EEL K + + I A + E G ++ AE + L+I
Sbjct: 152 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 211
Query: 180 SAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRI 222
+E YG+ + ++R+ +G +LL+GV G+ I + P NR+
Sbjct: 212 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHI----YDPENRL 250
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 107 bits (267), Expect = 2e-23
Identities = 70/223 (31%), Positives = 114/223 (51%), Gaps = 18/223 (8%)
Query: 13 MEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRI-SQQMDGLAP 71
ME E K G+D + VCR LG+ E +FGLQ+T K WL + ++ + P
Sbjct: 33 MEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKMDKKVLDHDVSKEEP 91
Query: 72 YRLKLRVKFFVE--PHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFG 129
KF+ E ++QE T+H+FFL +K+ +L + C PE +V L++ Q K+G
Sbjct: 92 VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYG 151
Query: 130 DYNQNTAKYNY---EELCAKELSSATL-------NSIVAKHKELEGTSQASAEYQVLQIV 179
DY+ + K + EEL K + + I A + E G ++ AE + L+I
Sbjct: 152 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 211
Query: 180 SAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRI 222
+E YG+ + ++R+ +G +LL+GV G+ I + P NR+
Sbjct: 212 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHI----YDPENRL 250
>gi|34328899 protein tyrosine phosphatase, non-receptor type 14
[Homo sapiens]
Length = 1187
Score = 100 bits (248), Expect = 3e-21
Identities = 66/222 (29%), Positives = 110/222 (49%), Gaps = 13/222 (5%)
Query: 3 CYVTRP---DAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLR 59
C+VTR D+ ++E + ++ G++CL V +RL + E YFGL F ++ W+ L
Sbjct: 20 CFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELE 79
Query: 60 NRISQQMDGLAPYRLKLRVKFFVEPHL--ILQEQTRHIFFLHIKEALLAGHLLCSPEQAV 117
+ + +D A L F P++ + QE TR+ ++L +K+ +L G L C+ +Q +
Sbjct: 80 KPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVI 139
Query: 118 ELSALLAQTKFGDYNQNTAKYNYEE-------LCAKELSSATLNSIVA-KHKELEGTSQA 169
L+ L Q FGDYNQ ++ E L +E L VA +HK G A
Sbjct: 140 RLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPA 199
Query: 170 SAEYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISI 211
AE + V ++ +G E V+D+ G + +G+ GI +
Sbjct: 200 EAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFV 241
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.132 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,664,490
Number of Sequences: 37866
Number of extensions: 644281
Number of successful extensions: 2628
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 2324
Number of HSP's gapped (non-prelim): 285
length of query: 445
length of database: 18,247,518
effective HSP length: 105
effective length of query: 340
effective length of database: 14,271,588
effective search space: 4852339920
effective search space used: 4852339920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.