Search of human proteins with 38505213

Search of human proteins with 38505213

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38505213 YTH domain containing 2 [Homo sapiens]
         (1430 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38505213 YTH domain containing 2 [Homo sapiens]                   2860   0.0  
gi|167830433 DEAH (Asp-Glu-Ala-His) box polypeptide 36 isoform 1...   334   3e-91
gi|167830436 DEAH (Asp-Glu-Ala-His) box polypeptide 36 isoform 2...   320   5e-87
gi|67782362 DEAH (Asp-Glu-Ala-His) box polypeptide 29 [Homo sapi...   288   3e-77
gi|39777586 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 [Homo ...   281   4e-75
gi|100913206 DEAH (Asp-Glu-Ala-His) box polypeptide 9 [Homo sapi...   268   4e-71
gi|20336290 DEAH (Asp-Glu-Ala-His) box polypeptide 30 isoform 2 ...   261   3e-69
gi|20336294 DEAH (Asp-Glu-Ala-His) box polypeptide 30 isoform 1 ...   261   3e-69
gi|38158022 DEAH (Asp-Glu-Ala-His) box polypeptide 34 [Homo sapi...   200   9e-51
gi|68509926 DEAH (Asp-Glu-Ala-His) box polypeptide 15 [Homo sapi...   186   2e-46
gi|20336302 DEAH (Asp-Glu-Ala-His) box polypeptide 33 [Homo sapi...   160   6e-39
gi|4826690 DEAH (Asp-Glu-Ala-His) box polypeptide 8 [Homo sapiens]    160   8e-39
gi|4503293 DEAH (Asp-Glu-Ala-His) box polypeptide 16 [Homo sapiens]   159   1e-38
gi|20544129 DEAH (Asp-Glu-Ala-His) box polypeptide 35 [Homo sapi...   159   2e-38
gi|17999539 DEAH (Asp-Glu-Ala-His) box polypeptide 38 [Homo sapi...   157   9e-38
gi|31542729 DEAH (Asp-Glu-Ala-His) box polypeptide 40 [Homo sapi...   150   1e-35
gi|166851804 tudor domain containing 9 [Homo sapiens]                 149   1e-35
gi|29029601 DEAH (Asp-Glu-Ala-His) box polypeptide 37 [Homo sapi...   136   2e-31
gi|169211440 PREDICTED: similar to DEAH (Asp-Glu-Ala-His) box po...   132   2e-30
gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]          130   7e-30
gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]          127   6e-29
gi|20336300 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32 [Hom...   108   5e-23
gi|163914394 DEAQ box polypeptide 1 (RNA-dependent ATPase) [Homo...    86   3e-16
gi|31377750 YTH domain family, member 1 [Homo sapiens]                 71   7e-12
gi|116235460 YTH domain family, member 3 [Homo sapiens]                67   9e-11
gi|116812575 high glucose-regulated protein 8 [Homo sapiens]           66   2e-10
gi|219842214 protein phosphatase 1, regulatory (inhibitor) subun...    49   3e-05
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun...    49   3e-05
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit...    49   3e-05
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...    49   5e-05

>gi|38505213 YTH domain containing 2 [Homo sapiens]
          Length = 1430

 Score = 2860 bits (7415), Expect = 0.0
 Identities = 1430/1430 (100%), Positives = 1430/1430 (100%)

Query: 1    MSRPSSVSPRQPAPGGGGGGGPSPCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGD 60
            MSRPSSVSPRQPAPGGGGGGGPSPCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGD
Sbjct: 1    MSRPSSVSPRQPAPGGGGGGGPSPCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGD 60

Query: 61   QREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLT 120
            QREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLT
Sbjct: 61   QREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLT 120

Query: 121  HNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTSGRLNNGIPQIPVK 180
            HNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTSGRLNNGIPQIPVK
Sbjct: 121  HNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTSGRLNNGIPQIPVK 180

Query: 181  RGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIP 240
            RGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIP
Sbjct: 181  RGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIP 240

Query: 241  CRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTL 300
            CRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTL
Sbjct: 241  CRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTL 300

Query: 301  MAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYF 360
            MAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYF
Sbjct: 301  MAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYF 360

Query: 361  GSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQTTLTEWYSAQEN 420
            GSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQTTLTEWYSAQEN
Sbjct: 361  GSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQTTLTEWYSAQEN 420

Query: 421  SFKPESQRQRTVLNVTDEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHK 480
            SFKPESQRQRTVLNVTDEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHK
Sbjct: 421  SFKPESQRQRTVLNVTDEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHK 480

Query: 481  DIDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNG 540
            DIDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNG
Sbjct: 481  DIDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNG 540

Query: 541  WMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFD 600
            WMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFD
Sbjct: 541  WMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFD 600

Query: 601  DEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFM 660
            DEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFM
Sbjct: 601  DEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFM 660

Query: 661  LHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFV 720
            LHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFV
Sbjct: 661  LHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFV 720

Query: 721  TMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHT 780
            TMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHT
Sbjct: 721  TMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHT 780

Query: 781  KLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPH 840
            KLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPH
Sbjct: 781  KLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPH 840

Query: 841  LGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMAL 900
            LGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMAL
Sbjct: 841  LGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMAL 900

Query: 901  LRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRD 960
            LRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRD
Sbjct: 901  LRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRD 960

Query: 961  VNTNSENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKKVRFHPASVLSQPQYKKIPPA 1020
            VNTNSENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKKVRFHPASVLSQPQYKKIPPA
Sbjct: 961  VNTNSENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKKVRFHPASVLSQPQYKKIPPA 1020

Query: 1021 NGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVTPVTILVFCGPARLASNALQEPSSF 1080
            NGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVTPVTILVFCGPARLASNALQEPSSF
Sbjct: 1021 NGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVTPVTILVFCGPARLASNALQEPSSF 1080

Query: 1081 RVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFTLEPEAASLLLQLRQKWHSLFLRRMRA 1140
            RVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFTLEPEAASLLLQLRQKWHSLFLRRMRA
Sbjct: 1081 RVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFTLEPEAASLLLQLRQKWHSLFLRRMRA 1140

Query: 1141 PSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRK 1200
            PSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRK
Sbjct: 1141 PSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRK 1200

Query: 1201 SSADTEFSDECTTAERVLMKSPSPALHPPQKYKDRGILHPKRGTEDRSDQSSLKSTDSSS 1260
            SSADTEFSDECTTAERVLMKSPSPALHPPQKYKDRGILHPKRGTEDRSDQSSLKSTDSSS
Sbjct: 1201 SSADTEFSDECTTAERVLMKSPSPALHPPQKYKDRGILHPKRGTEDRSDQSSLKSTDSSS 1260

Query: 1261 YPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRNLEISQQKGIWSTTPSNERKL 1320
            YPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRNLEISQQKGIWSTTPSNERKL
Sbjct: 1261 YPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRNLEISQQKGIWSTTPSNERKL 1320

Query: 1321 NRAFWESSIVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGSAGLGGVFKVEWIRKESLP 1380
            NRAFWESSIVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGSAGLGGVFKVEWIRKESLP
Sbjct: 1321 NRAFWESSIVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGSAGLGGVFKVEWIRKESLP 1380

Query: 1381 FQFAHHLLNPWNDNKKVQISRDGQELEPLVGEQLLQLWERLPLGEKNTTD 1430
            FQFAHHLLNPWNDNKKVQISRDGQELEPLVGEQLLQLWERLPLGEKNTTD
Sbjct: 1381 FQFAHHLLNPWNDNKKVQISRDGQELEPLVGEQLLQLWERLPLGEKNTTD 1430


>gi|167830433 DEAH (Asp-Glu-Ala-His) box polypeptide 36 isoform 1
            [Homo sapiens]
          Length = 1008

 Score =  334 bits (857), Expect = 3e-91
 Identities = 212/594 (35%), Positives = 329/594 (55%), Gaps = 64/594 (10%)

Query: 589  RELLKAYHHS-------FDDEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDR 641
            REL + Y  S        +D+KVDL+LI+ L+  I    + GA+L+FLPG+D I  L D 
Sbjct: 448  RELRRRYSASTVDVIEMMEDDKVDLNLIVALIRYIVLEEEDGAILVFLPGWDNISTLHDL 507

Query: 642  ILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVV 701
            ++    +    + ++ +  LHS M T +Q +V K  P GVRKI+++TNIAETSIT++DVV
Sbjct: 508  LM---SQVMFKSDKFLIIPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVV 564

Query: 702  FVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNML 761
            +VID GK+KE  FD  N ++ +   W+SKA+A QRKGRAGR +PG C+ L++ LR   + 
Sbjct: 565  YVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLD 624

Query: 762  EFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDT 821
            ++Q PE+LR PL+ELCL  K+L      IA FL +  +PP    V  +++ L  ++A+D 
Sbjct: 625  DYQLPEILRTPLEELCLQIKILRLGG--IAYFLSRLMDPPSNEAVLLSIRHLMELNALDK 682

Query: 822  WEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRA 881
             E+LT LG HLA LPVEPH+GKM+L   +  CLDP+LTIA +L+++DPFV+P    +++ 
Sbjct: 683  QEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIP--LGKEKI 740

Query: 882  AMLCRKRFTAGAFSDHMALLRAFQAWQKARSDG--WERAFCEKNFLSQATMEIIIGMRTQ 939
            A   RK       SDH+ ++ AF+ W++AR  G  +E+ +C + FLS  T++++  M+ Q
Sbjct: 741  ADARRKELAKDTRSDHLTVVNAFEGWEEARRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQ 800

Query: 940  LLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEK 999
                L  +GFV +R   D  + N NS+N  ++KA + AG+YP +  + R NL   G K K
Sbjct: 801  FAEHLLGAGFVSSRNPKD-PESNINSDNEKIIKAVICAGLYPKVAKI-RLNL---GKKRK 855

Query: 1000 KVRFHPAS---VLSQPQYKKIPPANGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVT 1056
             V+ +  +   V   P+   +   +           +WLIY    R   I  +  C+ V+
Sbjct: 856  MVKVYTKTDGLVAVHPKSVNVEQTD--------FHYNWLIYHLKMRTSSI-YLYDCTEVS 906

Query: 1057 PVTILVFCGPARLASNALQEPSSFRVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFTLE 1116
            P  +L F G   +  +  QE                            + +DEW+ F   
Sbjct: 907  PYCLLFFGGDISIQKDNDQE---------------------------TIAVDEWIVFQSP 939

Query: 1117 PEAASLLLQLRQKWHSLFLRRMRAPSK-PWSQV---DEATIRAIIAVLSTEEQS 1166
               A L+ +LR++   L   ++ +P    W+     D A + AII ++ T+E++
Sbjct: 940  ARIAHLVKELRKELDILLQEKIESPHPVDWNDTKSRDCAVLSAIIDLIKTQEKA 993



 Score =  194 bits (493), Expect = 5e-49
 Identities = 144/428 (33%), Positives = 219/428 (51%), Gaps = 47/428 (10%)

Query: 15  GGGGGGGPSPCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTE 74
           G GGGGG    G GG GR  G    R     +I +  A ++ +   + E +        E
Sbjct: 35  GSGGGGGGGGGGRGGRGRHPGHLKGR-----EIGMWYAKKQGQKNKEAERQ--------E 81

Query: 75  RAFIH-------RLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLTHNTKHAV 127
           RA +H       ++ Q L  V     K +   ++    +     H   T   T NT  + 
Sbjct: 82  RAVVHMDERREEQIVQLLNSVQAKNDKESEAQISWFAPED----HGYGTEVSTKNTPCSE 137

Query: 128 RSL-IQRFPVTNKERTELLPKT----ERGNVFAVEAENREMSKTSGRLNNGIPQIPVKRG 182
             L IQ   + N+E+     +     +R + + ++ EN        +L   + +      
Sbjct: 138 NKLDIQEKKLINQEKKMFRIRNRSYIDRDSEYLLQ-ENEPDGTLDQKLLEDLQKKKNDLR 196

Query: 183 ESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNG--IP 240
             E   FR+ LP +  Q+E+V +I  ++V +I GETG GKTTQ+ QF+LD+  + G    
Sbjct: 197 YIEMQHFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSA 256

Query: 241 CRIFCTQPRRLAAIAVAERVAAERRERIGQ--TIGYQIRLESRVSPKT-LLTFCTNGVLL 297
           CRI CTQPRR++AI+VAERVAAER E  G   + GYQIRL+SR+  K   + +CT G++L
Sbjct: 257 CRIVCTQPRRISAISVAERVAAERAESCGSGNSTGYQIRLQSRLPRKQGSILYCTTGIIL 316

Query: 298 RTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFI 357
           + L + D  LS+V+H+++DE+HER+  SD L+T ++DLL     LK+IL SA L+   F 
Sbjct: 317 QWLQS-DPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMSATLNAEKFS 375

Query: 358 RYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKE-----------MLKYKKEKQQEEK 406
            YFG+CP+I+I G  F V E  LED++    Y  ++           M  +   +++EEK
Sbjct: 376 EYFGNCPMIHIPGFTFPVVEYLLEDVIEKIRYVPEQKEHRSQFKRGFMQGHVNRQEKEEK 435

Query: 407 QQTTLTEW 414
           +      W
Sbjct: 436 EAIYKERW 443


>gi|167830436 DEAH (Asp-Glu-Ala-His) box polypeptide 36 isoform 2
            [Homo sapiens]
          Length = 994

 Score =  320 bits (821), Expect = 5e-87
 Identities = 208/594 (35%), Positives = 321/594 (54%), Gaps = 78/594 (13%)

Query: 589  RELLKAYHHS-------FDDEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDR 641
            REL + Y  S        +D+KVDL+LI+ L+  I    + GA+L+FLPG+D I  L D 
Sbjct: 448  RELRRRYSASTVDVIEMMEDDKVDLNLIVALIRYIVLEEEDGAILVFLPGWDNISTLHD- 506

Query: 642  ILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVV 701
                            + M     ++ +Q +V K  P GVRKI+++TNIAETSIT++DVV
Sbjct: 507  ----------------LLMSQVMFKSVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVV 550

Query: 702  FVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNML 761
            +VID GK+KE  FD  N ++ +   W+SKA+A QRKGRAGR +PG C+ L++ LR   + 
Sbjct: 551  YVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLD 610

Query: 762  EFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDT 821
            ++Q PE+LR PL+ELCL  K+L      IA FL +  +PP    V  +++ L  ++A+D 
Sbjct: 611  DYQLPEILRTPLEELCLQIKILRLGG--IAYFLSRLMDPPSNEAVLLSIRHLMELNALDK 668

Query: 822  WEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRA 881
             E+LT LG HLA LPVEPH+GKM+L   +  CLDP+LTIA +L+++DPFV+P    +++ 
Sbjct: 669  QEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIP--LGKEKI 726

Query: 882  AMLCRKRFTAGAFSDHMALLRAFQAWQKARSDG--WERAFCEKNFLSQATMEIIIGMRTQ 939
            A   RK       SDH+ ++ AF+ W++AR  G  +E+ +C + FLS  T++++  M+ Q
Sbjct: 727  ADARRKELAKDTRSDHLTVVNAFEGWEEARRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQ 786

Query: 940  LLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEK 999
                L  +GFV +R   D  + N NS+N  ++KA + AG+YP +  + R NL   G K K
Sbjct: 787  FAEHLLGAGFVSSRNPKD-PESNINSDNEKIIKAVICAGLYPKVAKI-RLNL---GKKRK 841

Query: 1000 KVRFHPAS---VLSQPQYKKIPPANGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVT 1056
             V+ +  +   V   P+   +   +           +WLIY    R   I  +  C+ V+
Sbjct: 842  MVKVYTKTDGLVAVHPKSVNVEQTD--------FHYNWLIYHLKMRTSSI-YLYDCTEVS 892

Query: 1057 PVTILVFCGPARLASNALQEPSSFRVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFTLE 1116
            P  +L F G   +  +  QE                            + +DEW+ F   
Sbjct: 893  PYCLLFFGGDISIQKDNDQE---------------------------TIAVDEWIVFQSP 925

Query: 1117 PEAASLLLQLRQKWHSLFLRRMRAPSK-PWSQV---DEATIRAIIAVLSTEEQS 1166
               A L+ +LR++   L   ++ +P    W+     D A + AII ++ T+E++
Sbjct: 926  ARIAHLVKELRKELDILLQEKIESPHPVDWNDTKSRDCAVLSAIIDLIKTQEKA 979



 Score =  194 bits (493), Expect = 5e-49
 Identities = 144/428 (33%), Positives = 219/428 (51%), Gaps = 47/428 (10%)

Query: 15  GGGGGGGPSPCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTE 74
           G GGGGG    G GG GR  G    R     +I +  A ++ +   + E +        E
Sbjct: 35  GSGGGGGGGGGGRGGRGRHPGHLKGR-----EIGMWYAKKQGQKNKEAERQ--------E 81

Query: 75  RAFIH-------RLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLTHNTKHAV 127
           RA +H       ++ Q L  V     K +   ++    +     H   T   T NT  + 
Sbjct: 82  RAVVHMDERREEQIVQLLNSVQAKNDKESEAQISWFAPED----HGYGTEVSTKNTPCSE 137

Query: 128 RSL-IQRFPVTNKERTELLPKT----ERGNVFAVEAENREMSKTSGRLNNGIPQIPVKRG 182
             L IQ   + N+E+     +     +R + + ++ EN        +L   + +      
Sbjct: 138 NKLDIQEKKLINQEKKMFRIRNRSYIDRDSEYLLQ-ENEPDGTLDQKLLEDLQKKKNDLR 196

Query: 183 ESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNG--IP 240
             E   FR+ LP +  Q+E+V +I  ++V +I GETG GKTTQ+ QF+LD+  + G    
Sbjct: 197 YIEMQHFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSA 256

Query: 241 CRIFCTQPRRLAAIAVAERVAAERRERIGQ--TIGYQIRLESRVSPKT-LLTFCTNGVLL 297
           CRI CTQPRR++AI+VAERVAAER E  G   + GYQIRL+SR+  K   + +CT G++L
Sbjct: 257 CRIVCTQPRRISAISVAERVAAERAESCGSGNSTGYQIRLQSRLPRKQGSILYCTTGIIL 316

Query: 298 RTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFI 357
           + L + D  LS+V+H+++DE+HER+  SD L+T ++DLL     LK+IL SA L+   F 
Sbjct: 317 QWLQS-DPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMSATLNAEKFS 375

Query: 358 RYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKE-----------MLKYKKEKQQEEK 406
            YFG+CP+I+I G  F V E  LED++    Y  ++           M  +   +++EEK
Sbjct: 376 EYFGNCPMIHIPGFTFPVVEYLLEDVIEKIRYVPEQKEHRSQFKRGFMQGHVNRQEKEEK 435

Query: 407 QQTTLTEW 414
           +      W
Sbjct: 436 EAIYKERW 443


>gi|67782362 DEAH (Asp-Glu-Ala-His) box polypeptide 29 [Homo sapiens]
          Length = 1369

 Score =  288 bits (736), Expect = 3e-77
 Identities = 197/581 (33%), Positives = 306/581 (52%), Gaps = 77/581 (13%)

Query: 603  KVDLDLIMHLLYNICHSCD----AGAVLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQV 658
            K++LDLI+ LL  +  S       GAVLIFLPG   I  L D +L +D+RF   + RY+V
Sbjct: 844  KINLDLILELLAYLDKSPQFRNIEGAVLIFLPGLAHIQQLYD-LLSNDRRFY--SERYKV 900

Query: 659  FMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALN 718
              LHS + T DQ      PP GVRKI+L+TNIAET IT+ DVVFVID+G+ KE  +   +
Sbjct: 901  IALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESS 960

Query: 719  FVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCL 778
             ++ L   ++SKASA+QR+GRAGR R G CFR+++R RF+  +++  PE+LR+PL+ELCL
Sbjct: 961  QMSSLVETFVSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCL 1020

Query: 779  HTKLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWE-DLTELGYHLADLPV 837
            H  +   +  P  DFL KA +PP   ++ NA+ +L+ I A +  E  LT LG HLA LPV
Sbjct: 1021 HI-MKCNLGSP-EDFLSKALDPPQLQVISNAMNLLRKIGACELNEPKLTPLGQHLAALPV 1078

Query: 838  EPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDH 897
               +GKM++   +  CLDP+ T+A  +  + PF  P    +K  A L  K   A A SDH
Sbjct: 1079 NVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTP--IGRKDEADLA-KSALAMADSDH 1135

Query: 898  MALLRAFQAWQKARSDGWERA---FCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARG 954
            + +  A+  W+KAR +G  R+   +C +NFL++ ++  +  ++ +L+  ++A+GF  +  
Sbjct: 1136 LTIYNAYLGWKKARQEGGYRSEITYCRRNFLNRTSLLTLEDVKQELIKLVKAAGFSSSTT 1195

Query: 955  G----GDIRDVNTNSENWAVVKAALVAGMYPNL--------VHVDRENLVLTGPKEKKVR 1002
                 G+      + +  A++KA LVAG+Y N+        V V  +   +    + K +
Sbjct: 1196 STSWEGNRASQTLSFQEIALLKAVLVAGLYDNVGKIIYTKSVDVTEKLACIVETAQGKAQ 1255

Query: 1003 FHPASVLSQPQYKKIPPANGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVTPVTILV 1062
             HP+SV    Q                    WL+Y E  R  R+  +R  + +TP  +L+
Sbjct: 1256 VHPSSVNRDLQ-----------------THGWLLYQEKIRYARV-YLRETTLITPFPVLL 1297

Query: 1063 FCGPARLASNALQEPSSFRVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFTLEPEAASL 1122
            F G                         D E++ +       L +D W++F    + A +
Sbjct: 1298 FGG-------------------------DIEVQHRE----RLLSIDGWIYFQAPVKIAVI 1328

Query: 1123 LLQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTE 1163
              QLR    S+  +++  P    S  ++  ++ I  ++ TE
Sbjct: 1329 FKQLRVLIDSVLRKKLENPK--MSLENDKILQIITELIKTE 1367



 Score =  193 bits (490), Expect = 1e-48
 Identities = 107/228 (46%), Positives = 145/228 (63%), Gaps = 9/228 (3%)

Query: 190 RQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKN---GIPCRIFCT 246
           RQ LPVF+ ++ IV+ +K ++VV++ GETGSGK+TQ+P FLL+D   N      C I CT
Sbjct: 569 RQQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKCNIVCT 628

Query: 247 QPRRLAAIAVAERVAAERRERIG-----QTIGYQIRLESRVSPKTLLTFCTNGVLLRTLM 301
           QPRR++A+++A RV  E     G        GYQIR+ESR    T L +CT GVLLR L 
Sbjct: 629 QPRRISAVSLANRVCDELGCENGPGGRNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQ 688

Query: 302 AGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFG 361
             D  LS V+HVIVDEVHER   SDFLL  L+++LQK   L LIL SA +D   F  YF 
Sbjct: 689 E-DGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRSDLHLILMSATVDSEKFSTYFT 747

Query: 362 SCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQT 409
            CP++ I GR + V+   LEDI+  TG+  ++  +Y ++  +EE++ T
Sbjct: 748 HCPILRISGRSYPVEVFHLEDIIEETGFVLEKDSEYCQKFLEEEEEVT 795


>gi|39777586 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 [Homo
            sapiens]
          Length = 1386

 Score =  281 bits (718), Expect = 4e-75
 Identities = 186/502 (37%), Positives = 284/502 (56%), Gaps = 49/502 (9%)

Query: 600  DDEKVDLDLIMHLLYNIC---HSCDAGAVLIFLPGYDEIVGLRDRI----LFDDKRFADN 652
            D EKV+L+LI  LL  I    HS   GA+L+FLPG  EI  L +++    LF+++R    
Sbjct: 822  DFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPGLAEIKMLYEQLQSNSLFNNRR---- 877

Query: 653  THRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEK 712
            ++R  +  LHS++ + +Q+ V   PPAGV KII+STNIAETSIT++DVV+VIDSGK+KEK
Sbjct: 878  SNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKIIISTNIAETSITIDDVVYVIDSGKMKEK 937

Query: 713  SFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQN-MLEFQTPELLRM 771
             +DA   +  L+  ++S+A+A+QRKGRAGR   G+CF LF+   + + +L+ Q PE+ R+
Sbjct: 938  RYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRV 997

Query: 772  PLQELCLHTKLLAPVNC-PIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGY 830
            PL++LCL  K+L   +   +     +  EPP    +R +   L+ + A+   E LT LGY
Sbjct: 998  PLEQLCLRIKILEMFSAHNLQSVFSRLIEPPHTDSLRASKIRLRDLGALTPDERLTPLGY 1057

Query: 831  HLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLP----TQASQKRAAMLCR 886
            HLA LPV+  +GK++L   + +CLDP LTIA +LA++ PFV P     +A+QK+      
Sbjct: 1058 HLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEF--- 1114

Query: 887  KRFTAGAFSDHMALLRAFQAWQKARSDGWERA--FCEKNFLSQATMEIIIGMRTQLLGQL 944
                A A SD++ALL+A++ WQ +  +G   +  +C +NFLS   ++ +  ++ Q    L
Sbjct: 1115 ----AFANSDYLALLQAYKGWQLSTKEGVRASYNYCRQNFLSGRVLQEMASLKRQFTELL 1170

Query: 945  RASGFV-----------RARGGGDIRD-----VNTNSENWAVVKAALVAGMYPNLVHVDR 988
               GF            RA+GG  + D      N+N+EN  ++ A L A +YPN+V V  
Sbjct: 1171 SDIGFAREGLRAREIEKRAQGGDGVLDATGEEANSNAENPKLISAMLCAALYPNVVQVKS 1230

Query: 989  ENLVLTGPKEKKVRFHPAS-----VLSQPQYKKIPPANGQAAAIKALPTDWLIYDEMTRA 1043
                        VR  P S     V     Y  I P++     ++   + +L+Y E  + 
Sbjct: 1231 PEGKFQKTSTGAVRMQPKSAELKFVTKNDGYVHIHPSSVN-YQVRHFDSPYLLYHEKIKT 1289

Query: 1044 HRIANIRCCSAVTPVTILVFCG 1065
             R+  IR CS V+   +++F G
Sbjct: 1290 SRVF-IRDCSMVSVYPLVLFGG 1310



 Score =  225 bits (573), Expect = 3e-58
 Identities = 133/295 (45%), Positives = 182/295 (61%), Gaps = 22/295 (7%)

Query: 155 AVEAENREMSKTSGRLNNGIPQIPVKRGESEFDSF---RQSLPVFEKQEEIVKIIKENKV 211
           +V AEN ++ K          Q  +K+   +F S    RQSLP +E++E I+ ++++++V
Sbjct: 513 SVHAENGKICK----------QFRMKQASRQFQSILQERQSLPAWEERETILNLLRKHQV 562

Query: 212 VLIVGETGSGKTTQIPQFLLDDCFKNGIP---CRIFCTQPRRLAAIAVAERVAAERRERI 268
           V+I G TG GKTTQIPQF+LDD   NG P     I CTQPRR++AI+VAERVA ER ER+
Sbjct: 563 VVISGMTGCGKTTQIPQFILDDSL-NGPPEKVANIICTQPRRISAISVAERVAKERAERV 621

Query: 269 GQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFL 328
           G T+GYQIRLES  S  T L +CT GVLLR L  GD+ L  V+H+IVDEVHER   SDFL
Sbjct: 622 GLTVGYQIRLESVKSSATRLLYCTTGVLLRRL-EGDTALQGVSHIIVDEVHERTEESDFL 680

Query: 329 LTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTG 388
           L  L+D++ + P L++IL SA L+  LF  YF SCPVI I GR F V + FLED +  T 
Sbjct: 681 LLVLKDIVSQRPGLQVILMSATLNAELFSDYFNSCPVITIPGRTFPVDQFFLEDAIAVTR 740

Query: 389 YTNKEMLKYKKEKQQEEKQQTTLTEWYSAQENSFKPESQRQRTVLNVTDEYDLLD 443
           Y  ++   Y +  +Q  K++            +F+   +  R  L++ D+  + D
Sbjct: 741 YVLQDGSPYMRSMKQISKEKLKARR----NRTAFEEVEEDLRLSLHLQDQDSVKD 791


>gi|100913206 DEAH (Asp-Glu-Ala-His) box polypeptide 9 [Homo sapiens]
          Length = 1270

 Score =  268 bits (684), Expect = 4e-71
 Identities = 208/611 (34%), Positives = 296/611 (48%), Gaps = 66/611 (10%)

Query: 600  DDEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVF 659
            ++++   +LI  LL  I      GAVL+FLPG++ I  ++  +  +       +HRYQ+ 
Sbjct: 628  NEKETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHF---GSHRYQIL 684

Query: 660  MLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNF 719
             LHS +   +Q+KV    P GV K+ILSTNIAETSIT+NDVV+VIDS K K K F A N 
Sbjct: 685  PLHSQIPREEQRKVFDPVPVGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNN 744

Query: 720  VTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLH 779
            +T    VW SK +  QRKGRAGR RPG CF L SR RF+ +    TPE+ R PL E+ L 
Sbjct: 745  MTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTPLHEIALS 804

Query: 780  TKLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEP 839
             KLL      I  FL KA EPPP   V  A   L+ +DA+D  ++LT LG  LA LP+EP
Sbjct: 805  IKLLRLGG--IGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEP 862

Query: 840  HLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMA 899
              GKM++   +    D I TIA    + +PF+     ++ +      + F    FSDH+A
Sbjct: 863  RFGKMMIMGCIFYVGDAICTIAAATCFPEPFI-----NEGKRLGYIHRNFAGNRFSDHVA 917

Query: 900  LLRAFQAWQKARSDGWER--AFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGD 957
            LL  FQAW  AR  G E    FCE   L+ AT+ +    + QL   L  SGF        
Sbjct: 918  LLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINSGFPE---DCL 974

Query: 958  IRDVNTNS---ENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKKVRFHPASVLSQPQY 1014
            +  V TN+    N  VV + L  G+YPN+ +   +  +LT  + +    H +SV      
Sbjct: 975  LTQVFTNTGPDNNLDVVISLLAFGVYPNVCYHKEKRKILT-TEGRNALIHKSSVNC---- 1029

Query: 1015 KKIPPANGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVTPVTILVFCGPARLASNAL 1074
                P + Q       P+ + ++ E  R  R  + +  + VTP+ +L+F      AS  +
Sbjct: 1030 ----PFSSQD---MKYPSPFFVFGEKIRT-RAISAKGMTLVTPLQLLLF------ASKKV 1075

Query: 1075 QEPSSFRVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFTLEPEAASLLLQLRQKWHSLF 1134
            Q              SD ++          + +D+W+   +  EAA+ +  LR    +L 
Sbjct: 1076 Q--------------SDGQI----------VLVDDWIKLQISHEAAACITGLRAAMEALV 1111

Query: 1135 LRRMRAPSKPWSQVDEATIRAIIAVLSTEEQS-AGLQQPSG---IGQRPRPMSSEELPLA 1190
            +   + P+   SQ+D    R +  +      S AG+    G    G  PRP         
Sbjct: 1112 VEVTKQPA-IISQLDPVNERMLNMIRQISRPSAAGINLMIGSTRYGDGPRPPKMARYDNG 1170

Query: 1191 SSWRSNNSRKS 1201
            S +R   S  S
Sbjct: 1171 SGYRRGGSSYS 1181



 Score =  197 bits (501), Expect = 6e-50
 Identities = 103/218 (47%), Positives = 147/218 (67%), Gaps = 6/218 (2%)

Query: 190 RQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKN--GIPCRIFCTQ 247
           R+ LPV + + EI++ I +N VV+I G TG GKTTQ+PQF+LDD  +N     C I  TQ
Sbjct: 385 RELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDRAAECNIVVTQ 444

Query: 248 PRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVS-PKTLLTFCTNGVLLRTLMAGDST 306
           PRR++A++VAERVA ER E  G++ GY +R ES +  P   + FCT GVLLR L AG   
Sbjct: 445 PRRISAVSVAERVAFERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAG--- 501

Query: 307 LSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVI 366
           +  ++HVIVDE+HERD  +DFLL  LRD++Q +P ++++L SA +D ++F  YF +CP+I
Sbjct: 502 IRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPII 561

Query: 367 YIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQE 404
            + GR + V+E FLED ++ T +      K KK+K  +
Sbjct: 562 EVYGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDD 599


>gi|20336290 DEAH (Asp-Glu-Ala-His) box polypeptide 30 isoform 2 [Homo
            sapiens]
          Length = 1155

 Score =  261 bits (668), Expect = 3e-69
 Identities = 169/507 (33%), Positives = 267/507 (52%), Gaps = 35/507 (6%)

Query: 596  HHSFDDE-KVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADNTH 654
            HH  +DE  +DLDL+  L+ +I    + G +L FLPG+ EI G++ R+    +    +  
Sbjct: 602  HHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRL---QEALGMHES 658

Query: 655  RYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSF 714
            +Y +  +HSN+   DQK + + PP GVRKI+L+TNIAETSIT+ND+V V+DSG  KE+ +
Sbjct: 659  KYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIVHVVDSGLHKEERY 718

Query: 715  DALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQ 774
            D    V+ L+ VW+S+A+ IQR+GRAGRC+ G  + LF R R + M+ FQ PE+LR PL+
Sbjct: 719  DLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLE 778

Query: 775  ELCLHTKLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLAD 834
             L L  K+  P    + +FL KA + P    V  AV +L+ I  +D  E LT LG  LA 
Sbjct: 779  NLVLQAKIHMPEKTAV-EFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAH 837

Query: 835  LPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAM-LCRKRFTAGA 893
            +  +P L K ++ A + +CL P+L +   L  RDPF   + + Q RA +   +   +  +
Sbjct: 838  ISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-RDPF---SSSLQNRAEVDKVKALLSHDS 893

Query: 894  FSDHMALLRAFQAWQKA---RSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFV 950
             SDH+A +RA   W++    +       + E+N L   ++  I G+  Q    +  +  V
Sbjct: 894  GSDHLAFVRAVAGWEEVLRWQDRSSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLV 953

Query: 951  RARGGGDIRDVNTN--SENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKKVRFHPASV 1008
                   +     N  SE   +VK  L+AG+YPNL+ V +      G   ++ +F P SV
Sbjct: 954  GKPSDCTLASAQCNEYSEEEELVKGVLMAGLYPNLIQVRQ------GKVTRQGKFKPNSV 1007

Query: 1009 LSQPQYKKI----PPANGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVTPVTILVFC 1064
              + +   I       N +A  ++   + WL Y    +++    +R  S V P+ +L+  
Sbjct: 1008 TYRTKSGNILLHKSTINREATRLR---SRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLT 1064

Query: 1065 -------GPARLASNALQEPSSFRVDG 1084
                      R A+ +L +    R++G
Sbjct: 1065 DGDVHIRDDGRRATISLSDSDLLRLEG 1091



 Score =  168 bits (425), Expect = 4e-41
 Identities = 117/345 (33%), Positives = 190/345 (55%), Gaps = 32/345 (9%)

Query: 83  QSLGLVSKSKGKGANR-YLTVKKKDGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKER 141
           +SLGLV ++     +  Y     ++  ET     T  +       + + +  +PV   E 
Sbjct: 274 KSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILRKIETFLNHYPV---ES 330

Query: 142 TELLPKTERGNVFAVEAENREMSKTSGRLNN---GIPQIP------VKRGESEFDSFRQS 192
           + + P+    +      +   + K SG L++   G P +P      V+  +S  + +R+ 
Sbjct: 331 SWIAPELRLQS-----DDILPLGKDSGPLSDPITGKPYVPLLEAEEVRLSQSLLELWRRR 385

Query: 193 LPVFEK---------QEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNG--IPC 241
            PV+++         ++ I+  I+++ VV+I G+TG GKTT+IPQ LL+     G    C
Sbjct: 386 GPVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARC 445

Query: 242 RIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKT-LLTFCTNGVLLRTL 300
            +  TQPRR++A++VA+RV+ E    + + +G+Q+RLES+   +   L FCT G+LLR L
Sbjct: 446 NVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFCTVGILLRKL 505

Query: 301 MAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYF 360
            +  S L  V+HVIVDEVHERD  +DFLL  L+ L + +P L+L+L SA  D   F RYF
Sbjct: 506 QSNPS-LEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYF 564

Query: 361 GSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEE 405
           G CPVI + G  + VKE +LEDIL   G  ++ + +++  + ++E
Sbjct: 565 GGCPVIKVPGFMYPVKEHYLEDILAKLG-KHQYLHRHRHHESEDE 608


>gi|20336294 DEAH (Asp-Glu-Ala-His) box polypeptide 30 isoform 1 [Homo
            sapiens]
          Length = 1194

 Score =  261 bits (668), Expect = 3e-69
 Identities = 169/507 (33%), Positives = 267/507 (52%), Gaps = 35/507 (6%)

Query: 596  HHSFDDE-KVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADNTH 654
            HH  +DE  +DLDL+  L+ +I    + G +L FLPG+ EI G++ R+    +    +  
Sbjct: 641  HHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRL---QEALGMHES 697

Query: 655  RYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSF 714
            +Y +  +HSN+   DQK + + PP GVRKI+L+TNIAETSIT+ND+V V+DSG  KE+ +
Sbjct: 698  KYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIVHVVDSGLHKEERY 757

Query: 715  DALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQ 774
            D    V+ L+ VW+S+A+ IQR+GRAGRC+ G  + LF R R + M+ FQ PE+LR PL+
Sbjct: 758  DLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLE 817

Query: 775  ELCLHTKLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLAD 834
             L L  K+  P    + +FL KA + P    V  AV +L+ I  +D  E LT LG  LA 
Sbjct: 818  NLVLQAKIHMPEKTAV-EFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAH 876

Query: 835  LPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAM-LCRKRFTAGA 893
            +  +P L K ++ A + +CL P+L +   L  RDPF   + + Q RA +   +   +  +
Sbjct: 877  ISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-RDPF---SSSLQNRAEVDKVKALLSHDS 932

Query: 894  FSDHMALLRAFQAWQKA---RSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFV 950
             SDH+A +RA   W++    +       + E+N L   ++  I G+  Q    +  +  V
Sbjct: 933  GSDHLAFVRAVAGWEEVLRWQDRSSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLV 992

Query: 951  RARGGGDIRDVNTN--SENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKKVRFHPASV 1008
                   +     N  SE   +VK  L+AG+YPNL+ V +      G   ++ +F P SV
Sbjct: 993  GKPSDCTLASAQCNEYSEEEELVKGVLMAGLYPNLIQVRQ------GKVTRQGKFKPNSV 1046

Query: 1009 LSQPQYKKI----PPANGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVTPVTILVFC 1064
              + +   I       N +A  ++   + WL Y    +++    +R  S V P+ +L+  
Sbjct: 1047 TYRTKSGNILLHKSTINREATRLR---SRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLT 1103

Query: 1065 -------GPARLASNALQEPSSFRVDG 1084
                      R A+ +L +    R++G
Sbjct: 1104 DGDVHIRDDGRRATISLSDSDLLRLEG 1130



 Score =  168 bits (425), Expect = 4e-41
 Identities = 117/345 (33%), Positives = 190/345 (55%), Gaps = 32/345 (9%)

Query: 83  QSLGLVSKSKGKGANR-YLTVKKKDGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKER 141
           +SLGLV ++     +  Y     ++  ET     T  +       + + +  +PV   E 
Sbjct: 313 KSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILRKIETFLNHYPV---ES 369

Query: 142 TELLPKTERGNVFAVEAENREMSKTSGRLNN---GIPQIP------VKRGESEFDSFRQS 192
           + + P+    +      +   + K SG L++   G P +P      V+  +S  + +R+ 
Sbjct: 370 SWIAPELRLQS-----DDILPLGKDSGPLSDPITGKPYVPLLEAEEVRLSQSLLELWRRR 424

Query: 193 LPVFEK---------QEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNG--IPC 241
            PV+++         ++ I+  I+++ VV+I G+TG GKTT+IPQ LL+     G    C
Sbjct: 425 GPVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARC 484

Query: 242 RIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKT-LLTFCTNGVLLRTL 300
            +  TQPRR++A++VA+RV+ E    + + +G+Q+RLES+   +   L FCT G+LLR L
Sbjct: 485 NVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSRGGALLFCTVGILLRKL 544

Query: 301 MAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYF 360
            +  S L  V+HVIVDEVHERD  +DFLL  L+ L + +P L+L+L SA  D   F RYF
Sbjct: 545 QSNPS-LEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYF 603

Query: 361 GSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEE 405
           G CPVI + G  + VKE +LEDIL   G  ++ + +++  + ++E
Sbjct: 604 GGCPVIKVPGFMYPVKEHYLEDILAKLG-KHQYLHRHRHHESEDE 647


>gi|38158022 DEAH (Asp-Glu-Ala-His) box polypeptide 34 [Homo
           sapiens]
          Length = 1143

 Score =  200 bits (508), Expect = 9e-51
 Identities = 127/364 (34%), Positives = 192/364 (52%), Gaps = 16/364 (4%)

Query: 602 EKVDLDLIMHLLYNICHSC---DAGAVLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQV 658
           EK+D    + +L +I H     + G +L+FL G  EI      +L   + +A +T R+ V
Sbjct: 355 EKLDPRPFLRVLESIDHKYPPEERGDLLVFLSGMAEI----SAVLEAAQTYASHTQRWVV 410

Query: 659 FMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALN 718
             LHS +  +DQ KV    P GVRK ILSTNIAETS+T++ + FV+DSGKVKE S+D   
Sbjct: 411 LPLHSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQA 470

Query: 719 FVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCL 778
            +  L+  WIS+ASA QRKGRAGR  PG+CFRL++   +     +  PE+ R+ L  L L
Sbjct: 471 KLQRLQEFWISQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVL 530

Query: 779 HTKLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVE 838
             K ++  +     F+    EPPP   +  A+  L+   A+D+ E LT +G  LA LPV+
Sbjct: 531 QMKSMSVGDPRTFPFI----EPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVD 586

Query: 839 PHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHM 898
             +GKM++   +   ++P+LTIA  L+ + PF    Q+S + AA    +R       D  
Sbjct: 587 VVIGKMLILGSMFSLVEPVLTIAAALSVQSPFTRSAQSSPECAA---ARRPLESDQGDPF 643

Query: 899 ALLRAFQAWQKARSDGW--ERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGG 956
            L   F AW + +S+     R +C +  + +  +  +  +R Q    L   G +      
Sbjct: 644 TLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAA 703

Query: 957 DIRD 960
            + D
Sbjct: 704 QVGD 707



 Score =  149 bits (375), Expect = 2e-35
 Identities = 80/190 (42%), Positives = 121/190 (63%), Gaps = 6/190 (3%)

Query: 190 RQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPR 249
           R +LP+ +    I++ +KE++VV++ G+TG GK+TQ+PQ+LL   F +     + CTQPR
Sbjct: 159 RAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSH-----VACTQPR 213

Query: 250 RLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLST 309
           R+A I++A+RV  E   + G  +GYQIR ES  S  T + F T G+LLR +   + +L  
Sbjct: 214 RIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQR-EPSLPQ 272

Query: 310 VTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQ 369
              +IVDEVHER   +DFLL  L+ LL   P LK+IL SA ++++LF  YF + PV+ + 
Sbjct: 273 YEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYFSNAPVVQVP 332

Query: 370 GRPFEVKEMF 379
           GR F +  ++
Sbjct: 333 GRLFPITVVY 342


>gi|68509926 DEAH (Asp-Glu-Ala-His) box polypeptide 15 [Homo sapiens]
          Length = 795

 Score =  186 bits (471), Expect = 2e-46
 Identities = 141/450 (31%), Positives = 221/450 (49%), Gaps = 47/450 (10%)

Query: 618  HSCDA--GAVLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLK 675
            H C+   G +L+FL G +EI     RI  +           ++  L+S +    Q+++ +
Sbjct: 343  HMCEEEEGDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFE 402

Query: 676  NPP------AGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWIS 729
             PP      A  RK+++STNIAETS+T++ VVFVID G  K+K ++    V  L +  IS
Sbjct: 403  PPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAIS 462

Query: 730  KASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQT-PELLRMPLQELCLHTKLLAPVNC 788
            KASA QR GRAGR RPG CFRL++   ++  ++  T PE+LR  L  + L  K L   + 
Sbjct: 463  KASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDL 522

Query: 789  PIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCA 848
               DF+    +PP    +  A+++L  + A++   DLTELG  +A+ P++P L KMV+ +
Sbjct: 523  VHFDFM----DPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIAS 578

Query: 849  VVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAW- 907
                C + +L+I   L+    FV PT+A  K+AA   + RF A    DH+ LL  + A+ 
Sbjct: 579  CDYNCSNEVLSITAMLSVPQCFVRPTEA--KKAADEAKMRF-AHIDGDHLTLLNVYHAFK 635

Query: 908  QKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSEN 967
            Q   S  W    C  NF++  ++     +R QL   +      R       RD   N   
Sbjct: 636  QNHESVQW----CYDNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTSRDYYIN--- 688

Query: 968  WAVVKAALVAGMYPNLVHVDRENLVLTGPKEKKVRFHPASVLSQPQYKKIPPANGQAAAI 1027
               ++ ALV G +  + H++R    LT    + V+ HP++VL                  
Sbjct: 689  ---IRKALVTGYFMQVAHLERTGHYLTVKDNQVVQLHPSTVLDH---------------- 729

Query: 1028 KALPTDWLIYDEMTRAHRIANIRCCSAVTP 1057
                 +W++Y+E     +   IR C+ + P
Sbjct: 730  ---KPEWVLYNEFVLTTK-NYIRTCTDIKP 755



 Score =  142 bits (357), Expect = 3e-33
 Identities = 85/206 (41%), Positives = 126/206 (61%), Gaps = 10/206 (4%)

Query: 190 RQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCR-IFCTQP 248
           R  LPV+E ++    I+  ++  ++VGETGSGKTTQIPQ+ ++       P R + CTQP
Sbjct: 134 RLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQP 193

Query: 249 RRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLS 308
           RR+AA++VA+RVA E    +GQ +GY IR E   S KT+L + T+G+LLR  M  D  L 
Sbjct: 194 RRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAM-NDPLLE 252

Query: 309 TVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYI 368
               +I+DE HER   +D L+  L++++++   LK+I+ SA LD   F  YF +CP++ I
Sbjct: 253 RYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTI 312

Query: 369 QGR--PFEV------KEMFLEDILRT 386
            GR  P E+      +  +LE  +RT
Sbjct: 313 PGRTHPVEIFYTPEPERDYLEAAIRT 338


>gi|20336302 DEAH (Asp-Glu-Ala-His) box polypeptide 33 [Homo sapiens]
          Length = 707

 Score =  160 bits (406), Expect = 6e-39
 Identities = 109/385 (28%), Positives = 180/385 (46%), Gaps = 17/385 (4%)

Query: 625  VLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKI 684
            +L+FL G +EI  +        K   D      V  L++++  + Q +V +  P G RK+
Sbjct: 291  ILVFLTGQEEIEAMSKTCRDIAKHLPDGCPAMLVLPLYASLPYAQQLRVFQGAPKGYRKV 350

Query: 685  ILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCR 744
            I+STNIAETSIT+  + +V+D+G VK K ++  + + +L +  +SK  A QR GRAGR  
Sbjct: 351  IISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGRED 410

Query: 745  PGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPPPAL 804
             GIC+RL++   F+   +   PE+ R  L  + L    +   N    DF+ K P P    
Sbjct: 411  SGICYRLYTEDEFEKFDKMTVPEIQRCNLASVMLQLLAMKVPNVLTFDFMSK-PSPDHIQ 469

Query: 805  IVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTL 864
                 + +L  ++  D    LT +G  +A  P+EP   K +L +    C + ILTI   L
Sbjct: 470  AAIAQLDLLGALEHKDDQLTLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLL 529

Query: 865  AYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKARSDGWERAFCEKNF 924
            +     VL    S++      RK+F +    DHM LL  ++ ++     G  + +C++NF
Sbjct: 530  SVDS--VLHNPPSRREEVQGVRKKFISSE-GDHMTLLNIYRTFKNL---GGNKDWCKENF 583

Query: 925  LSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLV 984
            ++   M ++  +R QL           A   GD+            V+  L   ++ +  
Sbjct: 584  VNSKNMTLVAEVRAQLRDICLKMSMPIASSRGDVES----------VRRCLAHSLFMSTA 633

Query: 985  HVDRENLVLTGPKEKKVRFHPASVL 1009
             +  +    T    + V  HP+SVL
Sbjct: 634  ELQPDGTYATTDTHQPVAIHPSSVL 658



 Score =  136 bits (342), Expect = 2e-31
 Identities = 80/197 (40%), Positives = 124/197 (62%), Gaps = 12/197 (6%)

Query: 190 RQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCF-KNGIPCRIFCTQP 248
           R+SLP+F+ + +++  ++     +++GETGSGKTTQIPQ+L +    + GI   I  TQP
Sbjct: 71  RRSLPIFQARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGISRQGI---IAVTQP 127

Query: 249 RRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLS 308
           RR+AAI++A RV+ E+R  +G+ +GY +R +   S  T + F T+G+LLR  ++ DS L 
Sbjct: 128 RRVAAISLATRVSDEKRTELGKLVGYTVRFDDVTSEDTRIKFLTDGMLLREAIS-DSLLR 186

Query: 309 TVTHVIVDEVHERDRFSDFLL------TKLRDLLQKHPTLKLILSSAALDVNLFIRYFGS 362
             + VI+DE HER   +D L        K R  L K P LK+I+ SA +DV+LF +YF  
Sbjct: 187 KYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELGKLP-LKVIVMSATMDVDLFSQYFNG 245

Query: 363 CPVIYIQGRPFEVKEMF 379
            PV+Y++GR   ++  +
Sbjct: 246 APVLYLEGRQHPIQVFY 262


>gi|4826690 DEAH (Asp-Glu-Ala-His) box polypeptide 8 [Homo sapiens]
          Length = 1220

 Score =  160 bits (405), Expect = 8e-39
 Identities = 112/395 (28%), Positives = 199/395 (50%), Gaps = 23/395 (5%)

Query: 623  GAVLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVR 682
            G +L+FL G +EI    + +    K    +     +  ++S + +  Q ++    P G R
Sbjct: 774  GDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSR 833

Query: 683  KIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGR 742
            K++++TNIAETS+T++ + +V+D G VK+K +++   +  L +  IS+A A QR GRAGR
Sbjct: 834  KVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGR 893

Query: 743  CRPGICFRLFSRLRFQN-MLEFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPP 801
              PG C+RL++   +++ ML    PE+ R  L    L  K +   +    DF+    + P
Sbjct: 894  TGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFM----DAP 949

Query: 802  PALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIA 861
            P   +  A++ L T+ A+D    LT LG  +A+ P+EP L KM++ +V L C + +LTI 
Sbjct: 950  PMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIV 1009

Query: 862  CTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKARSDGWERAFCE 921
              L+ ++ F  P     K+A    +K        DH+ LL  + +W   +++ +   +C 
Sbjct: 1010 SMLSVQNVFYRP---KDKQALADQKKAKFHQTEGDHLTLLAVYNSW---KNNKFSNPWCY 1063

Query: 922  KNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYP 981
            +NF+   ++     +R Q+LG +               DV +  ++   V+ A+ +G + 
Sbjct: 1064 ENFIQARSLRRAQDIRKQMLGIMDRHKL----------DVVSCGKSTVRVQKAICSGFFR 1113

Query: 982  NLVHVDRENLVLTGPKEKKVRFHPASVL--SQPQY 1014
            N    D +    T   ++ V  HP+S L   QP++
Sbjct: 1114 NAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEW 1148



 Score =  151 bits (381), Expect = 5e-36
 Identities = 101/300 (33%), Positives = 166/300 (55%), Gaps = 32/300 (10%)

Query: 102 VKKKDGSETAHAMMTCNLT---HNTKHAVRSL-IQRFPV-TNKERTELLPKTERGNVFAV 156
           VK  DGS +  AMM   L       K A R   +   P+  NK   + LP          
Sbjct: 465 VKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLP---------- 514

Query: 157 EAENREMSKTS---GRLNNGIPQIPV-----------KRGESEFDSFRQSLPVFEKQEEI 202
           +AE R+++      G + N IP+              K+ +      R+SLP+++ +E++
Sbjct: 515 DAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQL 574

Query: 203 VKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAA 262
           V+ + +N++++++GETGSGKTTQI Q+L +  + +    +I CTQPRR+AA++VA+RV+ 
Sbjct: 575 VQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSR--GKIGCTQPRRVAAMSVAKRVSE 632

Query: 263 ERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERD 322
           E    +GQ +GY IR E   SP+T++ + T+G+LLR  +  D  L+    +++DE HER 
Sbjct: 633 EFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLI-DPDLTQYAIIMLDEAHERT 691

Query: 323 RFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLED 382
             +D L   L+  +QK   +KLI++SA LD   F +YF   P+  I GR + V+ ++ ++
Sbjct: 692 IHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKE 751


>gi|4503293 DEAH (Asp-Glu-Ala-His) box polypeptide 16 [Homo sapiens]
          Length = 1041

 Score =  159 bits (403), Expect = 1e-38
 Identities = 116/392 (29%), Positives = 193/392 (49%), Gaps = 21/392 (5%)

Query: 623  GAVLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVR 682
            G +L+FL G +EI    + +    +R         V  +++N+ +  Q ++ +  P G R
Sbjct: 609  GDILVFLTGQEEIEAACEMLQDPCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGAR 668

Query: 683  KIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGR 742
            K++++TNIAETS T+  +++V+D G  K+KS++    +  L +   SKASA QR GRAGR
Sbjct: 669  KVVVATNIAETSPTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGR 728

Query: 743  CRPGICFRLFSRLRFQNMLEFQT-PELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPP 801
               G CFRL++   +Q+ LE  T PE+ R  L  + L  K L   +    DFL    +PP
Sbjct: 729  VAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFL----DPP 784

Query: 802  PALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIA 861
            P   +   ++ L  + A++   +LT  G  +A+LPV+P L KM+L +    C + ILT+A
Sbjct: 785  PYETLLLTLEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVA 844

Query: 862  CTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKARSDGWERAFCE 921
              L+  +      +     A       F  G   DH+ LL  +  W ++   G+   +C 
Sbjct: 845  AMLSVNNSIFYRPKDKVVHADNARVNFFLPG--GDHLVLLNVYTQWAES---GYSSQWCC 899

Query: 922  KNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYP 981
            +NF+   +M     +R QL G L      R   G     +++   ++  V+ A+ AG + 
Sbjct: 900  ENFVQFRSMRRARDVREQLEGLLE-----RVEVG-----LSSCQGDYIRVRKAITAGYFY 949

Query: 982  NLVHVDRENLVLTGPKEKKVRFHPASVLSQPQ 1013
            +   + R     T  +++ V  HP S L + Q
Sbjct: 950  HTARLTRSG-YRTVKQQQTVFIHPNSSLFEQQ 980



 Score =  152 bits (384), Expect = 2e-36
 Identities = 81/193 (41%), Positives = 125/193 (64%), Gaps = 2/193 (1%)

Query: 183 ESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCR 242
           +    + R+SLPVF  +EE++  I  ++V++I GETGSGKTTQIPQ+L ++ + N    +
Sbjct: 389 KESIQAVRRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNK-GMK 447

Query: 243 IFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMA 302
           I CTQPRR+AA++VA RVA E   ++G  +GY IR E   S +T+L + T+G+LLR  ++
Sbjct: 448 IACTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLS 507

Query: 303 GDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGS 362
            +  L++ + V+VDE HER   +D L   ++D+ +  P LK++++SA +D   F  +F  
Sbjct: 508 -EPDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDD 566

Query: 363 CPVIYIQGRPFEV 375
            PV  I GR F V
Sbjct: 567 APVFRIPGRRFPV 579


>gi|20544129 DEAH (Asp-Glu-Ala-His) box polypeptide 35 [Homo sapiens]
          Length = 703

 Score =  159 bits (402), Expect = 2e-38
 Identities = 123/426 (28%), Positives = 206/426 (48%), Gaps = 40/426 (9%)

Query: 623  GAVLIFLPGYDEIVGLRDRILFDDKRFADN--THRYQVFMLHSNMQTSDQKKVLKNPPAG 680
            G VL FL G +E+  +   ++   +  A        +V  +++ + + +Q KV +     
Sbjct: 275  GDVLAFLTGQEEVETVVSMLIEQARALARTGMKRHLRVLPMYAGLPSFEQMKVFERVSRS 334

Query: 681  VRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRA 740
            VRK+I++TN+AETSIT++ +V+VID G VK ++++    +  L +V +S+ASA QR GR 
Sbjct: 335  VRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRG 394

Query: 741  GRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEP 800
            GR R G C+RL++   F  + +   PE+ R  L  + L  K L   N     F+     P
Sbjct: 395  GRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFM----SP 450

Query: 801  PPALIVRNAVQMLKTIDAMDTWEDLTE-LGYHLADLPVEPHLGKMVLCAVVLKCLDPILT 859
            PPA  +  A+++L  +  +D    LTE LG  +A+ P+ P   KM+L +    C   IL+
Sbjct: 451  PPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILS 510

Query: 860  IACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKARSDGWERAF 919
            IA  +  ++ FV+P   +QK  A+   ++F A    DH+ +L  ++A+ K   D     +
Sbjct: 511  IAAMMQIQNIFVVP--PNQKSHAIRVHRKF-AVEEGDHLTMLNIYEAFIKHNKDS---KW 564

Query: 920  CEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGM 979
            C+++FL+   +     +R QL   L      R    GD            +V   +V+G 
Sbjct: 565  CQEHFLNYKGLVRAATVREQLKKLLVKFQVPRKSSEGDP----------DLVLRCIVSGF 614

Query: 980  YPNLVHVDRENLVLTGPKEKKVRFHPASVLSQPQYKKIPPANGQAAAIKALPTDWLIYDE 1039
            + N           T   + ++  HPASVL    Y + PP              W+IY+E
Sbjct: 615  FANAARFHSTGAYRTIRDDHELHIHPASVL----YAEKPPR-------------WVIYNE 657

Query: 1040 MTRAHR 1045
            + +  +
Sbjct: 658  VIQTSK 663



 Score =  122 bits (306), Expect = 2e-27
 Identities = 74/203 (36%), Positives = 119/203 (58%), Gaps = 13/203 (6%)

Query: 190 RQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPR 249
           RQ LPVF+ +  I+ +I+  + V+IVGETG GK+TQIPQ+L +  +       +  TQPR
Sbjct: 51  RQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGW-TAEGRVVGVTQPR 109

Query: 250 RLAAIAVAERVAAERRERIGQTIGYQIRLESRVSP-KTLLTFCTNGVLLRTLMAGDSTLS 308
           R+AA+ VA RVA ER   +G  +GY IR +       T + F T+G+L+R +M  D  L+
Sbjct: 110 RVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMV-DPLLT 168

Query: 309 TVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFG------- 361
             + +++DE HER  ++D  +  L+ + +K   L+LI++SA LD + F  +F        
Sbjct: 169 KYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNETSDP 228

Query: 362 ---SCPVIYIQGRPFEVKEMFLE 381
              +C ++ ++GR F V   +L+
Sbjct: 229 ARDTCVILTVEGRTFPVDIFYLQ 251


>gi|17999539 DEAH (Asp-Glu-Ala-His) box polypeptide 38 [Homo
           sapiens]
          Length = 1227

 Score =  157 bits (396), Expect = 9e-38
 Identities = 82/191 (42%), Positives = 128/191 (67%), Gaps = 5/191 (2%)

Query: 190 RQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKN-GIPCRIFCTQP 248
           RQ LP+F  Q+E++ II++N +V++VGETGSGKTTQ+ Q+L +D + + G+   I CTQP
Sbjct: 529 RQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLTQYLHEDGYTDYGM---IGCTQP 585

Query: 249 RRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLS 308
           RR+AA++VA+RV+ E    +G+ +GY IR E   S  TL+ + T+G+LLR  +  ++ L 
Sbjct: 586 RRVAAMSVAKRVSEEMGGNLGEEVGYAIRFEDCTSENTLIKYMTDGILLRESLR-EADLD 644

Query: 309 TVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYI 368
             + +I+DE HER   +D L   LR+++ +   LKLI++SA +D   F  +FG+ P+ +I
Sbjct: 645 HYSAIIMDEAHERSLNTDVLFGLLREVVARRSDLKLIVTSATMDAEKFAAFFGNVPIFHI 704

Query: 369 QGRPFEVKEMF 379
            GR F V  +F
Sbjct: 705 PGRTFPVDILF 715



 Score =  150 bits (378), Expect = 1e-35
 Identities = 102/319 (31%), Positives = 169/319 (52%), Gaps = 12/319 (3%)

Query: 623  GAVLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVR 682
            G +LIF+PG ++I    D+I+ +     +N     V  ++S + +  Q K+ +  P GVR
Sbjct: 741  GDILIFMPGQEDIEVTSDQIV-EHLEELENAPALAVLPIYSQLPSDLQAKIFQKAPDGVR 799

Query: 683  KIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGR 742
            K I++TNIAETS+TV+ ++FVIDSG  K K F+    +  L++  IS+A+A QR GRAGR
Sbjct: 800  KCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGR 859

Query: 743  CRPGICFRLFSRLRFQN-MLEFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPP 801
              PG CFRL+++  ++N +L    PE+ R  L  + L  K L   +     F+    +PP
Sbjct: 860  TGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFHFM----DPP 915

Query: 802  PALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIA 861
            P   + N++  L  + A+D    LT  G  + + P++P L KM++ +  + C   IL I 
Sbjct: 916  PEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIV 975

Query: 862  CTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKARSDGWERAFCE 921
              L+    F  P    ++   +  R++F A   SDH+  L  +  W   +++ +   +C 
Sbjct: 976  SMLSVPAIFYRPKGREEESDQI--REKF-AVPESDHLTYLNVYLQW---KNNNYSTIWCN 1029

Query: 922  KNFLSQATMEIIIGMRTQL 940
             +F+    M  +  +R QL
Sbjct: 1030 DHFIHAKAMRKVREVRAQL 1048


>gi|31542729 DEAH (Asp-Glu-Ala-His) box polypeptide 40 [Homo sapiens]
          Length = 779

 Score =  150 bits (378), Expect = 1e-35
 Identities = 115/407 (28%), Positives = 195/407 (47%), Gaps = 27/407 (6%)

Query: 622  AGAVLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQ--------VFMLHSNMQTSDQKKV 673
            AG +L+FL G  EI    + +LF      D  +  Q        +   + +M T  Q+++
Sbjct: 272  AGDILVFLTGQFEIEKSCE-LLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRI 330

Query: 674  LKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASA 733
               PP G+RK ++STNI+ TS+T++ + +V+D G VK+ + +    + +L++V ISK+ A
Sbjct: 331  FLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEA 390

Query: 734  IQRKGRAGRCRPGICFRLFSR-LRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCPIAD 792
            +QR GRAGR   G CFR++S+    Q M +   PE+ R  L  + L  K LA  +     
Sbjct: 391  LQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFP 450

Query: 793  FLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVVLK 852
            +L    +PP   ++  A++ L   DA+D    +T LG  + + P+ PHL   V+ A  L 
Sbjct: 451  YL----DPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLD 506

Query: 853  CLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFT--AGAFSDHMALLRAFQAWQKA 910
            C D +L IA  L+  + F+ P     ++ A    +     AG F+D   L   F   ++ 
Sbjct: 507  CEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIF---EQC 563

Query: 911  RSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAV 970
            +S G   ++C+K+++    +     +  QL   +R     + +   D            V
Sbjct: 564  KSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIR-----KLKQQSDFPKETFEGPKHEV 618

Query: 971  VKAALVAGMYPNLVH--VDRENLVLTGPKEKKVRFHPASVLSQPQYK 1015
            ++  L AG + N+    V R    + G +   V  HP+S L + + K
Sbjct: 619  LRRCLCAGYFKNVARRSVGRTFCTVDG-RGSPVHIHPSSALHEQETK 664



 Score =  132 bits (332), Expect = 2e-30
 Identities = 71/194 (36%), Positives = 126/194 (64%), Gaps = 10/194 (5%)

Query: 192 SLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCF-KNGIPCRIFCTQPRR 250
           + P+ +++++I++ +++N  +++ G TGSGKTTQ+P++L +  F ++G+   I  TQPR+
Sbjct: 52  TFPIQKQRKKIIQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGM---IGVTQPRK 108

Query: 251 LAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTV 310
           +AAI+VA+RVA E +  +G  +GYQ+R +   S +T + + T+G LL+ ++ GD  L+  
Sbjct: 109 VAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHIL-GDPNLTKF 167

Query: 311 THVIVDEVHERDRFSDFLLTKLRDLLQ-KHPT----LKLILSSAALDVNLFIRYFGSCPV 365
           + +I+DE HER   +D L   L+ L Q K P     LK+++ SA +++     +FG+CP+
Sbjct: 168 SVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPI 227

Query: 366 IYIQGRPFEVKEMF 379
             I GR + V+E F
Sbjct: 228 FDIPGRLYPVREKF 241


>gi|166851804 tudor domain containing 9 [Homo sapiens]
          Length = 1382

 Score =  149 bits (377), Expect = 1e-35
 Identities = 109/306 (35%), Positives = 154/306 (50%), Gaps = 23/306 (7%)

Query: 621 DAGAVLIFLPGYDEIVGLRDRILFDDKRFADNTH-RYQVFMLHSNMQTSDQKKVLKNPPA 679
           +  +VL+FLPG  EI  + + +           H R QV+ LHS++   +Q  V  +P  
Sbjct: 384 ERSSVLVFLPGLGEINYMHELL-------TSLVHKRLQVYPLHSSVALEEQNNVFLSPVP 436

Query: 680 GVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGR 739
           G RKIILSTNIAE+S+TV DV +VID    +    D       L++ W SK S  QRKGR
Sbjct: 437 GYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCNQRKGR 496

Query: 740 AGRCRPGICFRLFSRLRFQNML-EFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAP 798
           AGR   G C+RL  +  + N + +   PE+LR PL    L  KLL  +  P A  L  A 
Sbjct: 497 AGRVSRGYCYRLVHKDFWDNSIPDHVVPEMLRCPLGSTILKVKLL-DMGEPRA-LLATAL 554

Query: 799 EPPPALIVRNAVQMLKTIDAMDTW----------EDLTELGYHLADLPVEPHLGKMVLCA 848
            PP    +   + +LK + A+              +LT LG  LA LPV   LGK+++  
Sbjct: 555 SPPGLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVNQQLGKLIVLG 614

Query: 849 VVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQ 908
            V  CLD  L IA  L+ ++ F +P +  Q       +  F+  + SD +AL+ AF+ W+
Sbjct: 615 HVFGCLDECLIIAAALSLKNFFAMPFR--QHLDGYRNKVNFSGSSKSDCIALVEAFKTWK 672

Query: 909 KARSDG 914
             R  G
Sbjct: 673 ACRQTG 678



 Score =  139 bits (351), Expect = 1e-32
 Identities = 76/200 (38%), Positives = 118/200 (59%), Gaps = 10/200 (5%)

Query: 193 LPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLA 252
           LP+   +EE+V +I+ N VV+I G TGSGK+TQ+PQ++LD   +    C I  TQPR++ 
Sbjct: 132 LPISRYKEEVVSLIESNSVVIIHGATGSGKSTQLPQYILDHYVQRSAYCSIVVTQPRKIG 191

Query: 253 AIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTH 312
           A ++A  ++ ER   +G  +GYQ+ LE   +  T L + T GVLL+ +++  S L   TH
Sbjct: 192 ASSIARWISKERAWTLGGVVGYQVGLEKIATEDTRLIYMTTGVLLQKIVSAKS-LMEFTH 250

Query: 313 VIVDEVHERDRFSDFLLTKLRDLLQKHPT-LKLILSSAALDVNLFIRYF--------GSC 363
           +I+DEVHER    DFLL  +R LL+ +   +K++L SA +    F  YF           
Sbjct: 251 IIIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATISCKEFADYFAVPVQNKMNPA 310

Query: 364 PVIYIQGRPFEVKEMFLEDI 383
            +  ++G+P  V+E +L D+
Sbjct: 311 YIFEVEGKPHSVEEYYLNDL 330


>gi|29029601 DEAH (Asp-Glu-Ala-His) box polypeptide 37 [Homo
           sapiens]
          Length = 1157

 Score =  136 bits (342), Expect = 2e-31
 Identities = 102/322 (31%), Positives = 151/322 (46%), Gaps = 43/322 (13%)

Query: 658 VFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDAL 717
           V  L+S +    Q +V K PP G R  +++TN+AETS+T+  + +V+D GKVK++ +D +
Sbjct: 590 VLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRV 649

Query: 718 NFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELC 777
             V+  ++ W+S+ASA QR GRAGR  PG C+RL+S   F +  +F  PE+ R P+++L 
Sbjct: 650 TGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLI 709

Query: 778 LHTKLL---APVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWE----------- 823
           L  K L     +N P        P PP    +  A ++L  + A+   +           
Sbjct: 710 LQMKALNVEKVINFPF-------PTPPSVEALLAAEELLIALGALQPPQKAERVKQLQEN 762

Query: 824 ----DLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPF--------- 870
                +T LG  +A  PV P   KM+  +    CL   +TI  ++  R+ F         
Sbjct: 763 RLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEELDRPAAS 822

Query: 871 -VLPTQASQKRAAMLCRKRFTAG-----AFSDHMALLRAFQAWQKARSDGWERAFCEKNF 924
               T+   KRA +   KR  AG        D M LL A  A + A        FCE N 
Sbjct: 823 DEELTRLKSKRARVAQMKRTWAGQGASLKLGDLMVLLGAVGACEYA---SCTPQFCEANG 879

Query: 925 LSQATMEIIIGMRTQLLGQLRA 946
           L    M  I  +R QL   + A
Sbjct: 880 LRYKAMMEIRRLRGQLTTAVNA 901



 Score =  117 bits (293), Expect = 8e-26
 Identities = 78/211 (36%), Positives = 121/211 (57%), Gaps = 12/211 (5%)

Query: 177 IPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFK 236
           IPV R   E    R  LP+  +++ I++ + E+ +V++ GETGSGKTTQ+PQFL +  F 
Sbjct: 237 IPVNRSP-EMQEERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFS 295

Query: 237 NGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVL 296
           +     I  T+PRR+AA+A+++RVA E      + + YQIR E  V+ +T + F T+GVL
Sbjct: 296 SE-DSIIGVTEPRRVAAVAMSQRVAKE-MNLSQRVVSYQIRYEGNVTEETRIKFMTDGVL 353

Query: 297 LRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLL----QKHPTLKLILSSAALD 352
           L+ +   D  L     VI+DE HER  ++D L+  L  ++    +++  LKL++ SA L 
Sbjct: 354 LKEIQK-DFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLR 412

Query: 353 VNLFIR----YFGSCPVIYIQGRPFEVKEMF 379
           V  F +    +    PVI ++ R F V   F
Sbjct: 413 VEDFTQNPRLFAKPPPVIKVESRQFPVTVHF 443


>gi|169211440 PREDICTED: similar to DEAH (Asp-Glu-Ala-His) box
           polypeptide 40 [Homo sapiens]
          Length = 452

 Score =  132 bits (332), Expect = 2e-30
 Identities = 71/194 (36%), Positives = 126/194 (64%), Gaps = 10/194 (5%)

Query: 192 SLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCF-KNGIPCRIFCTQPRR 250
           + P+ +++++I++ +++N  +++ G TGSGKTTQ+P++L +  F ++G+   I  TQPR+
Sbjct: 52  TFPIQKQRKKIIQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGM---IGVTQPRK 108

Query: 251 LAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTV 310
           +AAI+VA+RVA E +  +G  +GYQ+R +   S +T + + T+G LL+ ++ GD  L+  
Sbjct: 109 VAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHIL-GDPNLTKF 167

Query: 311 THVIVDEVHERDRFSDFLLTKLRDLLQ-KHPT----LKLILSSAALDVNLFIRYFGSCPV 365
           + +I+DE HER   +D L   L+ L Q K P     LK+++ SA +++     +FG+CP+
Sbjct: 168 SVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPI 227

Query: 366 IYIQGRPFEVKEMF 379
             I GR + V+E F
Sbjct: 228 FDIPGRLYPVREKF 241



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 61/172 (35%), Positives = 97/172 (56%), Gaps = 10/172 (5%)

Query: 622 AGAVLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFML--------HSNMQTSDQKKV 673
           AG +L+FL G  EI    + +LF      D  +  Q  +L        + +M T  Q+++
Sbjct: 272 AGDILVFLTGQFEIEKSCE-LLFQMAESVDYDYDVQDTILDGLLILPCYGSMTTDQQRRI 330

Query: 674 LKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASA 733
              PP G+RK ++STNI+ TS+T++ + +V+D G VK+ + +    + +L++V ISK+ A
Sbjct: 331 FLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEA 390

Query: 734 IQRKGRAGRCRPGICFRLFSR-LRFQNMLEFQTPELLRMPLQELCLHTKLLA 784
           +QR GRAGR   G CFR++S+    Q M +   PE+ R  L  + L  K LA
Sbjct: 391 LQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLA 442


>gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]
          Length = 727

 Score =  130 bits (328), Expect = 7e-30
 Identities = 76/180 (42%), Positives = 104/180 (57%), Gaps = 7/180 (3%)

Query: 1246 DRSDQSSLKSTDSSSYPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRNLEISQ 1305
            DRS  S+ +S   S       S S  +  K   S         R+F++KS+N  N+ +++
Sbjct: 313  DRSGSSASESYAGSEKKHEKLSSSVRAVRKDQTSKLKYVLQDARFFLIKSNNHENVSLAK 372

Query: 1306 QKGIWSTTPSNERKLNRAFWESSIVYLVFSVQGSGHFQGFSRMSSEIGREKSQ-DW---- 1360
             KG+WST P NE+KLN AF  +  V L+FSV+ SG FQGF+R+SSE     S   W    
Sbjct: 373  AKGVWSTLPVNEKKLNLAFRSARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPA 432

Query: 1361 --GSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPLVGEQLLQLW 1418
               +  LGGVFK++WI +  LPF  + HL NPWN++K V+I RDGQE+E   G QL  L+
Sbjct: 433  GMSAKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLF 492


>gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]
          Length = 709

 Score =  127 bits (320), Expect = 6e-29
 Identities = 66/137 (48%), Positives = 91/137 (66%), Gaps = 7/137 (5%)

Query: 1289 RYFIMKSSNLRNLEISQQKGIWSTTPSNERKLNRAFWESSIVYLVFSVQGSGHFQGFSRM 1348
            R+F++KS+N  N+ +++ KG+WST P NE+KLN AF  +  V L+FSV+ SG FQGF+R+
Sbjct: 338  RFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRSARSVILIFSVRESGKFQGFARL 397

Query: 1349 SSEIGREKSQ-DW------GSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISR 1401
            SSE     S   W       +  LGGVFK++WI +  LPF  + HL NPWN++K V+I R
Sbjct: 398  SSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKIGR 457

Query: 1402 DGQELEPLVGEQLLQLW 1418
            DGQE+E   G QL  L+
Sbjct: 458  DGQEIELECGTQLCLLF 474


>gi|20336300 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32 [Homo
           sapiens]
          Length = 743

 Score =  108 bits (269), Expect = 5e-23
 Identities = 60/191 (31%), Positives = 115/191 (60%), Gaps = 9/191 (4%)

Query: 190 RQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDC----FKNGIPCRIFC 245
           R+ LP+++++   ++ + +N++V++ G+   GK+ Q+PQ+  + C    +++G    + C
Sbjct: 59  REDLPIWKEKYSFMENLLQNQIVIVSGDAKCGKSAQVPQWCAEYCLSIHYQHG---GVIC 115

Query: 246 TQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDS 305
           TQ  +   + +A RVA E    IG  +GY I  E+  + +T+L +CT+ +L R +M+ + 
Sbjct: 116 TQVHKQTVVQLALRVADEMDVNIGHEVGYVIPFENCCTNETILRYCTDDMLQREMMS-NP 174

Query: 306 TLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPV 365
            L +   +I+D++HER   +D LL  L+D+L   P LKLI++S+   ++    Y+G+ PV
Sbjct: 175 FLGSYGVIILDDIHERSIATDVLLGLLKDVLLARPELKLIINSSPHLISKLNSYYGNVPV 234

Query: 366 IYIQGR-PFEV 375
           I ++ + P EV
Sbjct: 235 IEVKNKHPVEV 245



 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 101/426 (23%), Positives = 188/426 (44%), Gaps = 24/426 (5%)

Query: 602  EKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFML 661
            +K   + I+ L++ I HS + G +++FL    +I  + + + +       +     V  L
Sbjct: 252  QKDSFESILRLIFEIHHSGEKGDIVVFLACEQDIEKVCETV-YQGSNLNPDLGELVVVPL 310

Query: 662  HSNMQTSDQK---KVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALN 718
            +   + S  K   +  K      R+++L+T+  E  I  N V FVID G  + K ++   
Sbjct: 311  YPKEKCSLFKPLDETEKRCQVYQRRVVLTTSSGEFLIWSNSVRFVIDVGVERRKVYNPRI 370

Query: 719  FVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSR-LRFQNMLEFQTPELLRMPLQELC 777
                L M  IS++ A  RK   G    G  F L++     ++M   +  E+    L  + 
Sbjct: 371  RANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEEFASKDMTPLKPAEMQEANLTSMV 430

Query: 778  LHTKLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPV 837
            L  K +        DF+ +   P P  +++ A++ L  + A+D   +L+E G  +++ P+
Sbjct: 431  LFMKRIDIAGLGHCDFMNR---PAPESLMQ-ALEDLDYLAALDNDGNLSEFGIIMSEFPL 486

Query: 838  EPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDH 897
            +P L K +L +    C+D +LTIA  +   + F      +++ AA+ C K F      DH
Sbjct: 487  DPQLSKSILASCEFDCVDEVLTIAAMVTAPNCFSHVPHGAEE-AALTCWKTFLHPE-GDH 544

Query: 898  MALLRAFQAWQ----KARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRAR 953
              L+  ++A+Q     + S+     +C   FL+ + + +   +R +LL  ++      A 
Sbjct: 545  FTLISIYKAYQDTTLNSSSEYCVEKWCRDYFLNCSALRMADVIRAELLEIIKRIELPYA- 603

Query: 954  GGGDIRDVNTNSENWAVVKAALVAGMYPNLVH-VDRENLVLTGPKEKKVRFHPASVLSQP 1012
                      + EN   +K AL++G +  +   VD     L    ++  + HP S  S  
Sbjct: 604  -----EPAFGSKENTLNIKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSGYSIT 658

Query: 1013 QYKKIP 1018
              KK+P
Sbjct: 659  --KKMP 662


>gi|163914394 DEAQ box polypeptide 1 (RNA-dependent ATPase) [Homo
           sapiens]
          Length = 717

 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 65/191 (34%), Positives = 104/191 (54%), Gaps = 8/191 (4%)

Query: 190 RQSLPVFEKQEEIVKIIKENK--VVLIVGETGSGKTTQIPQFLLDDCFKNGIPC-RIFCT 246
           RQ+LP++  +   ++ ++ N   VVL+ GE GSGK+TQIPQ+  +     G    ++  T
Sbjct: 42  RQALPIWAARFTFLEQLESNPTGVVLVSGEPGSGKSTQIPQWCAEFALARGFQKGQVTVT 101

Query: 247 QPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDST 306
           QP  LAA ++A RVA E    +G  +GY I  E    P TLL FC + +LL+ + +   T
Sbjct: 102 QPYPLAARSLALRVADEMDLTLGHEVGYSIPQEDCTGPNTLLRFCWDRLLLQEVASTRGT 161

Query: 307 LSTVTHVIVDEVHERDRFSDFLLTKLRDL-LQKHP--TLKLILSSAALDVNLFIRYFGSC 363
                 +++DE  ER   SD L   L+D  L+K P     ++++  AL+  L   ++G+ 
Sbjct: 162 -GAWGVLVLDEAQERSVASDSLQGLLQDARLEKLPGDLRVVVVTDPALEPKL-RAFWGNP 219

Query: 364 PVIYIQGRPFE 374
           P+++I   P E
Sbjct: 220 PIVHIPREPGE 230



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 117/504 (23%), Positives = 209/504 (41%), Gaps = 71/504 (14%)

Query: 616  ICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLK 675
            +C     G VL+FLP  +EI    + +  + +         +V  LH +   + Q  V +
Sbjct: 255  LCRKELPGDVLVFLPSEEEISLCCESLSREVESLLLQGLPPRVLPLHPDCGRAVQA-VYE 313

Query: 676  NPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQ 735
            +  A  RK++++  +A+ S ++  +  VIDSG      ++         +  ISK  A  
Sbjct: 314  DMDA--RKVVVTHWLADFSFSLPSIQHVIDSGLELRSVYNPRIRAEFQVLRPISKCQAEA 371

Query: 736  RKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQE--------LCLHTKLLAPVN 787
            R+ RA    PG C  L+ +    + LE + P L +  + E        L    ++  P  
Sbjct: 372  RRLRARGFPPGSCLCLYPK----SFLELEAPPLPQPRVCEENLSSLVLLLKRRQIAEPGE 427

Query: 788  CPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLC 847
            C   D      +P P  +++ A++ L  + A+D   DL++LG  L++ P+ P L K +L 
Sbjct: 428  CHFLD------QPAPEALMQ-ALEDLDYLAALDDDGDLSDLGVILSEFPLAPELAKALLA 480

Query: 848  AVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAF--- 904
            +    C+D +LT+A  L     F  P  ++++ A     +R       DH +L++ +   
Sbjct: 481  SCEFDCVDEMLTLAAMLTAAPGFTRPPLSAEEAAL----RRALEHTDGDHSSLIQVYEAF 536

Query: 905  ------QAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDI 958
                  +AW +AR   W  A C+ + L    +E++   R +L   L A G          
Sbjct: 537  IQSGADEAWCQARGLNW-AALCQAHKLRGELLELM--QRIELPLSLPAFG---------- 583

Query: 959  RDVNTNSENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKKVRFHPASVLSQPQYKKIP 1018
                 + +N   ++ ALV+G +  +   D +    TG        H A + S   Y+   
Sbjct: 584  -----SEQNRRDLQKALVSGYFLKVAR-DTDG---TGNYLLLTHKHVAQLSSYCCYR--- 631

Query: 1019 PANGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVTPV--TILVFCGPARLASNALQE 1076
                 +    A P  W++Y   T    I+   C S V+ +   +LV   P    SN    
Sbjct: 632  -----SRRAPARPPPWVLYHNFT----ISKDNCLSIVSEIQPQMLVELAPPYFLSNLPPS 682

Query: 1077 PSSFRVDGIPNDSSDSEMEDKTTA 1100
             S   ++ +    +DS    K+++
Sbjct: 683  ESRDLLNQLREGMADSTAGSKSSS 706


>gi|31377750 YTH domain family, member 1 [Homo sapiens]
          Length = 559

 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 48/133 (36%), Positives = 69/133 (51%), Gaps = 4/133 (3%)

Query: 1289 RYFIMKSSNLRNLEISQQKGIWSTTPSNERKLNRAFWESSI---VYLVFSVQGSGHFQGF 1345
            R FI+KS +  ++  S +  IW +T    ++L+ AF   S    VYL+FSV GSGHF G 
Sbjct: 390  RVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRCMSSKGPVYLLFSVNGSGHFCGV 449

Query: 1346 SRMSSEIGREKSQD-WGSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQ 1404
            + M S +    S   W      G F V+WI  + +P     H+    NDNK V  SRD Q
Sbjct: 450  AEMKSPVDYGTSAGVWSQDKWKGKFDVQWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQ 509

Query: 1405 ELEPLVGEQLLQL 1417
            E+     +Q+L++
Sbjct: 510  EVPLEKAKQVLKI 522


>gi|116235460 YTH domain family, member 3 [Homo sapiens]
          Length = 585

 Score = 67.4 bits (163), Expect = 9e-11
 Identities = 44/133 (33%), Positives = 68/133 (51%), Gaps = 4/133 (3%)

Query: 1289 RYFIMKSSNLRNLEISQQKGIWSTTPSNERKLNRAFWE---SSIVYLVFSVQGSGHFQGF 1345
            R FI+KS +  ++  S +  IW +T    ++L+ A+        +YL+FSV GSGHF G 
Sbjct: 417  RVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGKGPLYLLFSVNGSGHFCGV 476

Query: 1346 SRMSSEIGREKSQD-WGSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQ 1404
            + M S +        W      G F+V+WI  + +P     H+    NDNK V  SRD Q
Sbjct: 477  AEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQ 536

Query: 1405 ELEPLVGEQLLQL 1417
            E+     +Q+L++
Sbjct: 537  EVPLEKAKQVLKI 549


>gi|116812575 high glucose-regulated protein 8 [Homo sapiens]
          Length = 579

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 44/133 (33%), Positives = 67/133 (50%), Gaps = 4/133 (3%)

Query: 1289 RYFIMKSSNLRNLEISQQKGIWSTTPSNERKLNRAFWESS---IVYLVFSVQGSGHFQGF 1345
            R FI+KS +  ++  S +  IW +T    ++L+ A+   +    VYL+FSV GSGHF G 
Sbjct: 411  RVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGV 470

Query: 1346 SRMSSEIGREKSQD-WGSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQ 1404
            + M S +        W      G F V WI  + +P     H+    N+NK V  SRD Q
Sbjct: 471  AEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQ 530

Query: 1405 ELEPLVGEQLLQL 1417
            E+     +Q+L++
Sbjct: 531  EVPLEKAKQVLKI 543


>gi|219842214 protein phosphatase 1, regulatory (inhibitor) subunit
           12A isoform b [Homo sapiens]
          Length = 943

 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 29/94 (30%), Positives = 45/94 (47%)

Query: 500 DYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLL 559
           D RH+++  TAL VAA +G+   ++ LI  G +V+ K  +GW  L  A H+G+ E   +L
Sbjct: 105 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 164

Query: 560 ESYSASLEFGNLDESSLVQTNGSDLSAEDRELLK 593
                 +E  N    +       D+     EL K
Sbjct: 165 VDNLCDMEMVNKVGQTAFDVADEDILGYLEELQK 198


>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
           12A isoform a [Homo sapiens]
          Length = 1030

 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 29/94 (30%), Positives = 45/94 (47%)

Query: 500 DYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLL 559
           D RH+++  TAL VAA +G+   ++ LI  G +V+ K  +GW  L  A H+G+ E   +L
Sbjct: 192 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 251

Query: 560 ESYSASLEFGNLDESSLVQTNGSDLSAEDRELLK 593
                 +E  N    +       D+     EL K
Sbjct: 252 VDNLCDMEMVNKVGQTAFDVADEDILGYLEELQK 285



 Score = 31.6 bits (70), Expect = 5.7
 Identities = 37/161 (22%), Positives = 61/161 (37%), Gaps = 37/161 (22%)

Query: 399 KEKQQEEKQQTTLTEWYSAQENSFKPESQRQRTVLNVTDEYDLLDDGGDAVFSQLTEKDV 458
           K    ++K+   L  W  ++ +   P  +RQ+T +         DDG  AVF        
Sbjct: 2   KMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVK-------FDDG--AVF-------- 44

Query: 459 NCLEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRG 518
                     + AC S      D D   ++ H        ++Y + +   TAL  A    
Sbjct: 45  ----------LAACSSG-----DTDEVLKLLH----RGADINYANVD-GLTALHQACIDD 84

Query: 519 FASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLL 559
               V+ L+  GAN++   + GW+ L  A   G  +I + L
Sbjct: 85  NVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFL 125


>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit
           12A isoform a [Homo sapiens]
          Length = 1030

 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 29/94 (30%), Positives = 45/94 (47%)

Query: 500 DYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLL 559
           D RH+++  TAL VAA +G+   ++ LI  G +V+ K  +GW  L  A H+G+ E   +L
Sbjct: 192 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 251

Query: 560 ESYSASLEFGNLDESSLVQTNGSDLSAEDRELLK 593
                 +E  N    +       D+     EL K
Sbjct: 252 VDNLCDMEMVNKVGQTAFDVADEDILGYLEELQK 285



 Score = 31.6 bits (70), Expect = 5.7
 Identities = 37/161 (22%), Positives = 61/161 (37%), Gaps = 37/161 (22%)

Query: 399 KEKQQEEKQQTTLTEWYSAQENSFKPESQRQRTVLNVTDEYDLLDDGGDAVFSQLTEKDV 458
           K    ++K+   L  W  ++ +   P  +RQ+T +         DDG  AVF        
Sbjct: 2   KMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVK-------FDDG--AVF-------- 44

Query: 459 NCLEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRG 518
                     + AC S      D D   ++ H        ++Y + +   TAL  A    
Sbjct: 45  ----------LAACSSG-----DTDEVLKLLH----RGADINYANVD-GLTALHQACIDD 84

Query: 519 FASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLL 559
               V+ L+  GAN++   + GW+ L  A   G  +I + L
Sbjct: 85  NVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFL 125


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 23/57 (40%), Positives = 36/57 (63%)

Query: 509 TALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSAS 565
           TAL+ A+  G    VE+L+  G N+  +   GW AL WA + G+T++V+LL S+ A+
Sbjct: 73  TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGAN 129



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 27/76 (35%), Positives = 39/76 (51%), Gaps = 1/76 (1%)

Query: 492 ILTENVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFG 551
           +L +   VD R+ E   T LM+AA +G    V++LI  GAN + +  + W AL  A   G
Sbjct: 24  LLEKCKDVDERN-ECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEG 82

Query: 552 QTEIVDLLESYSASLE 567
              IV+ L     +LE
Sbjct: 83  HVHIVEELLKCGVNLE 98



 Score = 35.4 bits (80), Expect = 0.40
 Identities = 25/71 (35%), Positives = 37/71 (52%), Gaps = 2/71 (2%)

Query: 492 ILTENVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFG 551
           +L     VD +    S TAL+VA   G+   V++++    NV+    +G  AL  A   G
Sbjct: 189 LLAMGADVD-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEG 247

Query: 552 QTEIV-DLLES 561
            TEIV DLL++
Sbjct: 248 HTEIVQDLLDA 258



 Score = 32.7 bits (73), Expect = 2.6
 Identities = 21/61 (34%), Positives = 28/61 (45%)

Query: 507 SATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASL 566
           S   ++ AAGRG A  V  L+  GA V+     G   L WA   G  E V  L +  A +
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196

Query: 567 E 567
           +
Sbjct: 197 D 197



 Score = 30.8 bits (68), Expect = 9.8
 Identities = 25/91 (27%), Positives = 39/91 (42%), Gaps = 1/91 (1%)

Query: 485 FAQVFHLILTENVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMAL 544
           + Q    IL  N +V+    + + TALM+A+  G    V+ L+  G  V+    +G   L
Sbjct: 215 YTQSVKEILKRNPNVNLTDKDGN-TALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVL 273

Query: 545 DWAKHFGQTEIVDLLESYSASLEFGNLDESS 575
             A   G  EIV  L    A ++    D  +
Sbjct: 274 IGAVRGGHVEIVRALLQKYADIDIRGQDNKT 304


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,171,140
Number of Sequences: 37866
Number of extensions: 2599105
Number of successful extensions: 19078
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 193
Number of HSP's successfully gapped in prelim test: 181
Number of HSP's that attempted gapping in prelim test: 16916
Number of HSP's gapped (non-prelim): 1935
length of query: 1430
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1315
effective length of database: 13,892,928
effective search space: 18269200320
effective search space used: 18269200320
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.