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Search of human proteins with 124248558
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|124248558 F-box and WD-40 domain protein 9 [Homo sapiens]
(458 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|124248558 F-box and WD-40 domain protein 9 [Homo sapiens] 934 0.0
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 76 7e-14
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 76 7e-14
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 76 7e-14
gi|32189425 WD repeat domain 69 [Homo sapiens] 70 5e-12
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 69 7e-12
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 69 7e-12
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 69 7e-12
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 67 4e-11
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 67 4e-11
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 64 3e-10
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 64 3e-10
gi|217330644 WD repeat domain 12 protein [Homo sapiens] 62 8e-10
gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens] 62 1e-09
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 60 4e-09
gi|31543297 neutral sphingomyelinase (N-SMase) activation associ... 57 3e-08
gi|221625547 neutral sphingomyelinase (N-SMase) activation assoc... 57 3e-08
gi|23199987 WD repeat domain 5B [Homo sapiens] 56 6e-08
gi|16554629 WD repeat domain 5 [Homo sapiens] 56 8e-08
gi|16554627 WD repeat domain 5 [Homo sapiens] 56 8e-08
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 55 1e-07
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] 55 1e-07
gi|113865883 WD repeat domain 38 [Homo sapiens] 55 1e-07
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 55 2e-07
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 55 2e-07
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 55 2e-07
gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog... 54 3e-07
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 54 4e-07
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ... 54 4e-07
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 52 9e-07
>gi|124248558 F-box and WD-40 domain protein 9 [Homo sapiens]
Length = 458
Score = 934 bits (2413), Expect = 0.0
Identities = 458/458 (100%), Positives = 458/458 (100%)
Query: 1 MELPLGRCDDSRTWDDDSDPESETDPDAQAKAYVARVLSPPKSGLAFSRPSQLSTPAASP 60
MELPLGRCDDSRTWDDDSDPESETDPDAQAKAYVARVLSPPKSGLAFSRPSQLSTPAASP
Sbjct: 1 MELPLGRCDDSRTWDDDSDPESETDPDAQAKAYVARVLSPPKSGLAFSRPSQLSTPAASP 60
Query: 61 SASEPRAASRVSAVSEPGLLSLPPELLLEICSYLDARLVLHVLSRVCHALRDLVSDHVTW 120
SASEPRAASRVSAVSEPGLLSLPPELLLEICSYLDARLVLHVLSRVCHALRDLVSDHVTW
Sbjct: 61 SASEPRAASRVSAVSEPGLLSLPPELLLEICSYLDARLVLHVLSRVCHALRDLVSDHVTW 120
Query: 121 RLRALRRVRAPYPVVEEKNFDWPAACIALEQHLSRWAEDGRWVEYFCLAEGHVASVDSVL 180
RLRALRRVRAPYPVVEEKNFDWPAACIALEQHLSRWAEDGRWVEYFCLAEGHVASVDSVL
Sbjct: 121 RLRALRRVRAPYPVVEEKNFDWPAACIALEQHLSRWAEDGRWVEYFCLAEGHVASVDSVL 180
Query: 181 LLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWSLAAQDHRVC 240
LLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWSLAAQDHRVC
Sbjct: 181 LLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWSLAAQDHRVC 240
Query: 241 SGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKVTIYDPRAGPALL 300
SGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKVTIYDPRAGPALL
Sbjct: 241 SGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKVTIYDPRAGPALL 300
Query: 301 KHQQLHSRPVLTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQLDSYLLCMSYQEPQLW 360
KHQQLHSRPVLTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQLDSYLLCMSYQEPQLW
Sbjct: 301 KHQQLHSRPVLTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQLDSYLLCMSYQEPQLW 360
Query: 361 AGDNQGLLHVFANRNGCFQLIRSFDVGHSFPITGIQYSVGALYTTSTDKTIRVHVPTDPP 420
AGDNQGLLHVFANRNGCFQLIRSFDVGHSFPITGIQYSVGALYTTSTDKTIRVHVPTDPP
Sbjct: 361 AGDNQGLLHVFANRNGCFQLIRSFDVGHSFPITGIQYSVGALYTTSTDKTIRVHVPTDPP 420
Query: 421 RTICTRRHDNGLNRVCAEGNLVVAGSGDLSLEVWRLQA 458
RTICTRRHDNGLNRVCAEGNLVVAGSGDLSLEVWRLQA
Sbjct: 421 RTICTRRHDNGLNRVCAEGNLVVAGSGDLSLEVWRLQA 458
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 75.9 bits (185), Expect = 7e-14
Identities = 96/435 (22%), Positives = 181/435 (41%), Gaps = 48/435 (11%)
Query: 46 AFSRPSQLSTPAASPSASEPRAASRVSAVSEPG-----LLSLPPELLLEICSYLDARLVL 100
++S P +L + EP + V EP + LP EL L + S+L+ + +L
Sbjct: 125 SWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLL 184
Query: 101 HVLSRVCHALRDLVSDHVTWRLRALRR-VRAPYPVVEEK-------NFDWPAACIALEQH 152
++ C R L D++ WR + + P + K + W +A I +
Sbjct: 185 QA-AQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRI 243
Query: 153 LSRWAEDGRWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQV 212
+ W ++ + +GH V + L G + +SGS D + +W + +
Sbjct: 244 DTNWRRGE--LKSPKVLKGHDDHVITCLQFCGNRI-VSGSDDNTLKVWS-----AVTGKC 295
Query: 213 LIKTLGTKRNSTHEGWVWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKA-SSAVLC 271
L +G H G VWS +D+ + SGS D T+K+W+ A G+ + +S V C
Sbjct: 296 LRTLVG------HTGGVWSSQMRDNIIISGSTDRTLKVWN-AETGECIHTLYGHTSTVRC 348
Query: 272 LSYLPDILVTGTYDKKVTIYDPRAGPALLKHQQL-HSRPVLTLLADDRHIISGSEDHTLV 330
+ +V+G+ D + ++D G L H + H V + D R ++SG+ D +
Sbjct: 349 MHLHEKRVVSGSRDATLRVWDIETGQCL--HVLMGHVAAVRCVQYDGRRVVSGAYDFMVK 406
Query: 331 VVDRRANSVLQRLQ-LDSYLLCMSYQEPQLWAGDNQGLLHVFANRNG-CFQLIRSFDVGH 388
V D + L LQ + + + + + +G + V+ G C + GH
Sbjct: 407 VWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL----TGH 462
Query: 389 SFPITGIQYSVGALYTTSTDKTIRVHVPTDPPRTICTR------RHDNGLNRVCAEGNLV 442
+G++ L + + D T+++ D C + +H + + + N V
Sbjct: 463 QSLTSGMELKDNILVSGNADSTVKI---WDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFV 519
Query: 443 VAGSGDLSLEVWRLQ 457
+ S D ++++W L+
Sbjct: 520 ITSSDDGTVKLWDLK 534
Score = 49.7 bits (117), Expect = 6e-06
Identities = 38/131 (29%), Positives = 63/131 (48%), Gaps = 18/131 (13%)
Query: 170 EGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWV 229
+GH V S+ G +SGS D ++ +WD+ E+ + G H+
Sbjct: 420 QGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDV-----ETGNCIHTLTG------HQSLT 466
Query: 230 WSLAAQDHRVCSGSWDSTVKLWDMAADGQQF----GEIKASSAVLCLSYLPDILVTGTYD 285
+ +D+ + SG+ DSTVK+WD+ GQ G K SAV CL + + ++T + D
Sbjct: 467 SGMELKDNILVSGNADSTVKIWDIKT-GQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDD 525
Query: 286 KKVTIYDPRAG 296
V ++D + G
Sbjct: 526 GTVKLWDLKTG 536
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 75.9 bits (185), Expect = 7e-14
Identities = 96/435 (22%), Positives = 181/435 (41%), Gaps = 48/435 (11%)
Query: 46 AFSRPSQLSTPAASPSASEPRAASRVSAVSEPG-----LLSLPPELLLEICSYLDARLVL 100
++S P +L + EP + V EP + LP EL L + S+L+ + +L
Sbjct: 243 SWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLL 302
Query: 101 HVLSRVCHALRDLVSDHVTWRLRALRR-VRAPYPVVEEK-------NFDWPAACIALEQH 152
++ C R L D++ WR + + P + K + W +A I +
Sbjct: 303 QA-AQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRI 361
Query: 153 LSRWAEDGRWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQV 212
+ W ++ + +GH V + L G + +SGS D + +W + +
Sbjct: 362 DTNWRRGE--LKSPKVLKGHDDHVITCLQFCGNRI-VSGSDDNTLKVWS-----AVTGKC 413
Query: 213 LIKTLGTKRNSTHEGWVWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKA-SSAVLC 271
L +G H G VWS +D+ + SGS D T+K+W+ A G+ + +S V C
Sbjct: 414 LRTLVG------HTGGVWSSQMRDNIIISGSTDRTLKVWN-AETGECIHTLYGHTSTVRC 466
Query: 272 LSYLPDILVTGTYDKKVTIYDPRAGPALLKHQQL-HSRPVLTLLADDRHIISGSEDHTLV 330
+ +V+G+ D + ++D G L H + H V + D R ++SG+ D +
Sbjct: 467 MHLHEKRVVSGSRDATLRVWDIETGQCL--HVLMGHVAAVRCVQYDGRRVVSGAYDFMVK 524
Query: 331 VVDRRANSVLQRLQ-LDSYLLCMSYQEPQLWAGDNQGLLHVFANRNG-CFQLIRSFDVGH 388
V D + L LQ + + + + + +G + V+ G C + GH
Sbjct: 525 VWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL----TGH 580
Query: 389 SFPITGIQYSVGALYTTSTDKTIRVHVPTDPPRTICTR------RHDNGLNRVCAEGNLV 442
+G++ L + + D T+++ D C + +H + + + N V
Sbjct: 581 QSLTSGMELKDNILVSGNADSTVKI---WDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFV 637
Query: 443 VAGSGDLSLEVWRLQ 457
+ S D ++++W L+
Sbjct: 638 ITSSDDGTVKLWDLK 652
Score = 49.7 bits (117), Expect = 6e-06
Identities = 38/131 (29%), Positives = 63/131 (48%), Gaps = 18/131 (13%)
Query: 170 EGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWV 229
+GH V S+ G +SGS D ++ +WD+ E+ + G H+
Sbjct: 538 QGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDV-----ETGNCIHTLTG------HQSLT 584
Query: 230 WSLAAQDHRVCSGSWDSTVKLWDMAADGQQF----GEIKASSAVLCLSYLPDILVTGTYD 285
+ +D+ + SG+ DSTVK+WD+ GQ G K SAV CL + + ++T + D
Sbjct: 585 SGMELKDNILVSGNADSTVKIWDIKT-GQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDD 643
Query: 286 KKVTIYDPRAG 296
V ++D + G
Sbjct: 644 GTVKLWDLKTG 654
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 75.9 bits (185), Expect = 7e-14
Identities = 96/435 (22%), Positives = 181/435 (41%), Gaps = 48/435 (11%)
Query: 46 AFSRPSQLSTPAASPSASEPRAASRVSAVSEPG-----LLSLPPELLLEICSYLDARLVL 100
++S P +L + EP + V EP + LP EL L + S+L+ + +L
Sbjct: 163 SWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLL 222
Query: 101 HVLSRVCHALRDLVSDHVTWRLRALRR-VRAPYPVVEEK-------NFDWPAACIALEQH 152
++ C R L D++ WR + + P + K + W +A I +
Sbjct: 223 QA-AQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRI 281
Query: 153 LSRWAEDGRWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQV 212
+ W ++ + +GH V + L G + +SGS D + +W + +
Sbjct: 282 DTNWRRGE--LKSPKVLKGHDDHVITCLQFCGNRI-VSGSDDNTLKVWS-----AVTGKC 333
Query: 213 LIKTLGTKRNSTHEGWVWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKA-SSAVLC 271
L +G H G VWS +D+ + SGS D T+K+W+ A G+ + +S V C
Sbjct: 334 LRTLVG------HTGGVWSSQMRDNIIISGSTDRTLKVWN-AETGECIHTLYGHTSTVRC 386
Query: 272 LSYLPDILVTGTYDKKVTIYDPRAGPALLKHQQL-HSRPVLTLLADDRHIISGSEDHTLV 330
+ +V+G+ D + ++D G L H + H V + D R ++SG+ D +
Sbjct: 387 MHLHEKRVVSGSRDATLRVWDIETGQCL--HVLMGHVAAVRCVQYDGRRVVSGAYDFMVK 444
Query: 331 VVDRRANSVLQRLQ-LDSYLLCMSYQEPQLWAGDNQGLLHVFANRNG-CFQLIRSFDVGH 388
V D + L LQ + + + + + +G + V+ G C + GH
Sbjct: 445 VWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL----TGH 500
Query: 389 SFPITGIQYSVGALYTTSTDKTIRVHVPTDPPRTICTR------RHDNGLNRVCAEGNLV 442
+G++ L + + D T+++ D C + +H + + + N V
Sbjct: 501 QSLTSGMELKDNILVSGNADSTVKI---WDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFV 557
Query: 443 VAGSGDLSLEVWRLQ 457
+ S D ++++W L+
Sbjct: 558 ITSSDDGTVKLWDLK 572
Score = 49.7 bits (117), Expect = 6e-06
Identities = 38/131 (29%), Positives = 63/131 (48%), Gaps = 18/131 (13%)
Query: 170 EGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWV 229
+GH V S+ G +SGS D ++ +WD+ E+ + G H+
Sbjct: 458 QGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDV-----ETGNCIHTLTG------HQSLT 504
Query: 230 WSLAAQDHRVCSGSWDSTVKLWDMAADGQQF----GEIKASSAVLCLSYLPDILVTGTYD 285
+ +D+ + SG+ DSTVK+WD+ GQ G K SAV CL + + ++T + D
Sbjct: 505 SGMELKDNILVSGNADSTVKIWDIKT-GQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDD 563
Query: 286 KKVTIYDPRAG 296
V ++D + G
Sbjct: 564 GTVKLWDLKTG 574
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 69.7 bits (169), Expect = 5e-12
Identities = 75/310 (24%), Positives = 138/310 (44%), Gaps = 37/310 (11%)
Query: 166 FCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTH 225
F + + H+ + +V L + GS ++GS DR LWD G E N + H
Sbjct: 85 FKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTAS-GEELNTL----------EGH 133
Query: 226 EGWVWSLAAQD---HRVCSGSWDSTVKLWDMAADGQQFGEIKASSA-VLCLSYLPD--IL 279
V+++A + ++ +GS+D T KLW + G+ + + +A ++CLS+ P ++
Sbjct: 134 RNVVYAIAFNNPYGDKIATGSFDKTCKLWSVET-GKCYHTFRGHTAEIVCLSFNPQSTLV 192
Query: 280 VTGTYDKKVTIYDPRAGPALLKHQQLHSRPVLTL---LADDRHIISGSEDHTLVVVD--- 333
TG+ D ++D + G + + HS +++L + DR II+GS DHT+VV D
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRG-HSAEIISLSFNTSGDR-IITGSFDHTVVVWDADT 250
Query: 334 -RRANSVLQRLQLDSYLLCMSYQEPQLWAGDNQGLLHVFANRNG-CFQLIRSFDVGHSFP 391
R+ N ++ + ++ + G ++ NG C + GH
Sbjct: 251 GRKVNILIGHC-AEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATL----TGHDDE 305
Query: 392 I--TGIQYSVGALYTTSTDKTIRVHVPTDPPRTICTRRHDNGLNRVC--AEGNLVVAGSG 447
I + Y+ + T S D T R+ H+ ++++ +GN ++ GS
Sbjct: 306 ILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSS 365
Query: 448 DLSLEVWRLQ 457
D + +W Q
Sbjct: 366 DKTARIWDAQ 375
Score = 35.8 bits (81), Expect = 0.083
Identities = 47/190 (24%), Positives = 77/190 (40%), Gaps = 45/190 (23%)
Query: 157 AEDGRWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKT 216
A+ GR V GH A + S SL L+GS D+ LWD
Sbjct: 248 ADTGRKVNILI---GHCAEISSASFNWDCSLILTGSMDKTCKLWD--------------- 289
Query: 217 LGTKRNSTHEGWVWSLAAQDHRVCSGSWDSTVKLWDMA-ADGQQFGEIKASSAVLCLSYL 275
+T+ V +L D + +D T KL A ADG I +++ C++ L
Sbjct: 290 ------ATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT--ARIFSAATRKCIAKL 341
Query: 276 P---------------DILVTGTYDKKVTIYDPRAGPALLKHQQLHSRPVLTLLADDRH- 319
+ L+TG+ DK I+D + G L+ + H+ + + + +
Sbjct: 342 EGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQC-LQVLEGHTDEIFSCAFNYKGN 400
Query: 320 -IISGSEDHT 328
+I+GS+D+T
Sbjct: 401 IVITGSKDNT 410
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 69.3 bits (168), Expect = 7e-12
Identities = 93/421 (22%), Positives = 173/421 (41%), Gaps = 60/421 (14%)
Query: 71 VSAVSEPGLLSLPPELLLEICSYLDARLVLHVLSRVCHALRDLVSDHVTWRLRALRRVRA 130
++A+ E GL + +L SYLDAR L VC + ++S+ + W+ R VR
Sbjct: 120 ITALPEQGLDHIAENIL----SYLDARS-LCAAELVCKEWQRVISEGMLWKKLIERMVRT 174
Query: 131 P---YPVVEEKNFD--------------------WPAACIALEQHLSRWAEDGRWVEYF- 166
+ E + +D +P +E S W ++
Sbjct: 175 DPLWKGLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQ 234
Query: 167 CLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHE 226
C +E S L +SG RD ++ +WD L E +VL + H
Sbjct: 235 CRSEN---SKGVYCLQYDDEKIISGLRDNSIKIWDKTSL--ECLKVL---------TGHT 280
Query: 227 GWVWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDK 286
G V L + + +GS DSTV++WD+ I + AVL L + ++VT + D+
Sbjct: 281 GSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDR 340
Query: 287 KVTIYDPRAGPALLKHQQL--HSRPVLTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQ 344
+ ++D + + + L H V + DD++I+S S D T+ V ++ L
Sbjct: 341 SIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLN 400
Query: 345 LDSY-LLCMSYQEPQLWAGDNQGLLHVFANRNG-CFQLIRSFDVGHSFPITGIQYSVGAL 402
+ C+ Y++ + +G + + ++ G C +++ GH + I++ +
Sbjct: 401 GHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLE----GHEELVRCIRFDNKRI 456
Query: 403 YTTSTDKTIRVH------VPTDPPRTICTR---RHDNGLNRVCAEGNLVVAGSGDLSLEV 453
+ + D I+V P P T+C R H + R+ + +++ S D ++ +
Sbjct: 457 VSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILI 516
Query: 454 W 454
W
Sbjct: 517 W 517
Score = 61.6 bits (148), Expect = 1e-09
Identities = 59/239 (24%), Positives = 111/239 (46%), Gaps = 18/239 (7%)
Query: 229 VWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKV 288
V+ L D ++ SG D+++K+WD + + +VLCL Y ++VTG+ D V
Sbjct: 243 VYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTV 302
Query: 289 TIYDPRAGPAL--LKHQQLHSRPVLTLLADDRHIISGSEDHTLVVVD-RRANSVLQRLQL 345
++D G L L H H+ VL L + +++ S+D ++ V D A + R L
Sbjct: 303 RVWDVNTGEVLNTLIH---HNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVL 359
Query: 346 DSYLLCMS---YQEPQLWAGDNQGLLHVFANRNGCFQLIRSFDVGHSFPITGIQYSVGAL 402
+ ++ + + + + + V++ + +R+ + GH I +QY +
Sbjct: 360 VGHRAAVNVVDFDDKYIVSASGDRTIKVWS--TSTCEFVRTLN-GHKRGIACLQYRDRLV 416
Query: 403 YTTSTDKTIRVHVPTDPPRTICTR---RHDNGLNRVCAEGNLVVAGSGDLSLEVWRLQA 458
+ S+D TIR+ D C R H+ + + + +V+G+ D ++VW LQA
Sbjct: 417 VSGSSDNTIRL---WDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQA 472
Score = 58.2 bits (139), Expect = 2e-08
Identities = 47/193 (24%), Positives = 84/193 (43%), Gaps = 2/193 (1%)
Query: 266 SSAVLCLSYLPDILVTGTYDKKVTIYDPRAGPALLKHQQLHSRPVLTLLADDRHIISGSE 325
S V CL Y + +++G D + I+D + LK H+ VL L D+R I++GS
Sbjct: 240 SKGVYCLQYDDEKIISGLRDNSIKIWD-KTSLECLKVLTGHTGSVLCLQYDERVIVTGSS 298
Query: 326 DHTLVVVDRRANSVLQRL-QLDSYLLCMSYQEPQLWAGDNQGLLHVFANRNGCFQLIRSF 384
D T+ V D VL L + +L + + + + V+ + +R
Sbjct: 299 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRV 358
Query: 385 DVGHSFPITGIQYSVGALYTTSTDKTIRVHVPTDPPRTICTRRHDNGLNRVCAEGNLVVA 444
VGH + + + + + S D+TI+V + H G+ + LVV+
Sbjct: 359 LVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVS 418
Query: 445 GSGDLSLEVWRLQ 457
GS D ++ +W ++
Sbjct: 419 GSSDNTIRLWDIE 431
Score = 57.0 bits (136), Expect = 3e-08
Identities = 50/171 (29%), Positives = 79/171 (46%), Gaps = 21/171 (12%)
Query: 171 GHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVW 230
GH A+V+ V +S S DR + +W + S ++TL + H+ +
Sbjct: 361 GHRAAVNVVDF--DDKYIVSASGDRTIKVW------STSTCEFVRTL-----NGHKRGIA 407
Query: 231 SLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKVTI 290
L +D V SGS D+T++LWD+ V C+ + +V+G YD K+ +
Sbjct: 408 CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 467
Query: 291 Y------DPRAGPALLKHQQL--HSRPVLTLLADDRHIISGSEDHTLVVVD 333
+ DPRA + L + L HS V L D+ IIS S D T+++ D
Sbjct: 468 WDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWD 518
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 69.3 bits (168), Expect = 7e-12
Identities = 93/421 (22%), Positives = 173/421 (41%), Gaps = 60/421 (14%)
Query: 71 VSAVSEPGLLSLPPELLLEICSYLDARLVLHVLSRVCHALRDLVSDHVTWRLRALRRVRA 130
++A+ E GL + +L SYLDAR L VC + ++S+ + W+ R VR
Sbjct: 86 ITALPEQGLDHIAENIL----SYLDARS-LCAAELVCKEWQRVISEGMLWKKLIERMVRT 140
Query: 131 P---YPVVEEKNFD--------------------WPAACIALEQHLSRWAEDGRWVEYF- 166
+ E + +D +P +E S W ++
Sbjct: 141 DPLWKGLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQ 200
Query: 167 CLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHE 226
C +E S L +SG RD ++ +WD L E +VL + H
Sbjct: 201 CRSEN---SKGVYCLQYDDEKIISGLRDNSIKIWDKTSL--ECLKVL---------TGHT 246
Query: 227 GWVWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDK 286
G V L + + +GS DSTV++WD+ I + AVL L + ++VT + D+
Sbjct: 247 GSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDR 306
Query: 287 KVTIYDPRAGPALLKHQQL--HSRPVLTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQ 344
+ ++D + + + L H V + DD++I+S S D T+ V ++ L
Sbjct: 307 SIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLN 366
Query: 345 LDSY-LLCMSYQEPQLWAGDNQGLLHVFANRNG-CFQLIRSFDVGHSFPITGIQYSVGAL 402
+ C+ Y++ + +G + + ++ G C +++ GH + I++ +
Sbjct: 367 GHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLE----GHEELVRCIRFDNKRI 422
Query: 403 YTTSTDKTIRVH------VPTDPPRTICTR---RHDNGLNRVCAEGNLVVAGSGDLSLEV 453
+ + D I+V P P T+C R H + R+ + +++ S D ++ +
Sbjct: 423 VSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILI 482
Query: 454 W 454
W
Sbjct: 483 W 483
Score = 61.6 bits (148), Expect = 1e-09
Identities = 59/239 (24%), Positives = 111/239 (46%), Gaps = 18/239 (7%)
Query: 229 VWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKV 288
V+ L D ++ SG D+++K+WD + + +VLCL Y ++VTG+ D V
Sbjct: 209 VYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTV 268
Query: 289 TIYDPRAGPAL--LKHQQLHSRPVLTLLADDRHIISGSEDHTLVVVD-RRANSVLQRLQL 345
++D G L L H H+ VL L + +++ S+D ++ V D A + R L
Sbjct: 269 RVWDVNTGEVLNTLIH---HNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVL 325
Query: 346 DSYLLCMS---YQEPQLWAGDNQGLLHVFANRNGCFQLIRSFDVGHSFPITGIQYSVGAL 402
+ ++ + + + + + V++ + +R+ + GH I +QY +
Sbjct: 326 VGHRAAVNVVDFDDKYIVSASGDRTIKVWS--TSTCEFVRTLN-GHKRGIACLQYRDRLV 382
Query: 403 YTTSTDKTIRVHVPTDPPRTICTR---RHDNGLNRVCAEGNLVVAGSGDLSLEVWRLQA 458
+ S+D TIR+ D C R H+ + + + +V+G+ D ++VW LQA
Sbjct: 383 VSGSSDNTIRL---WDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQA 438
Score = 58.2 bits (139), Expect = 2e-08
Identities = 47/193 (24%), Positives = 84/193 (43%), Gaps = 2/193 (1%)
Query: 266 SSAVLCLSYLPDILVTGTYDKKVTIYDPRAGPALLKHQQLHSRPVLTLLADDRHIISGSE 325
S V CL Y + +++G D + I+D + LK H+ VL L D+R I++GS
Sbjct: 206 SKGVYCLQYDDEKIISGLRDNSIKIWD-KTSLECLKVLTGHTGSVLCLQYDERVIVTGSS 264
Query: 326 DHTLVVVDRRANSVLQRL-QLDSYLLCMSYQEPQLWAGDNQGLLHVFANRNGCFQLIRSF 384
D T+ V D VL L + +L + + + + V+ + +R
Sbjct: 265 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRV 324
Query: 385 DVGHSFPITGIQYSVGALYTTSTDKTIRVHVPTDPPRTICTRRHDNGLNRVCAEGNLVVA 444
VGH + + + + + S D+TI+V + H G+ + LVV+
Sbjct: 325 LVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVS 384
Query: 445 GSGDLSLEVWRLQ 457
GS D ++ +W ++
Sbjct: 385 GSSDNTIRLWDIE 397
Score = 57.0 bits (136), Expect = 3e-08
Identities = 50/171 (29%), Positives = 79/171 (46%), Gaps = 21/171 (12%)
Query: 171 GHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVW 230
GH A+V+ V +S S DR + +W + S ++TL + H+ +
Sbjct: 327 GHRAAVNVVDF--DDKYIVSASGDRTIKVW------STSTCEFVRTL-----NGHKRGIA 373
Query: 231 SLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKVTI 290
L +D V SGS D+T++LWD+ V C+ + +V+G YD K+ +
Sbjct: 374 CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 433
Query: 291 Y------DPRAGPALLKHQQL--HSRPVLTLLADDRHIISGSEDHTLVVVD 333
+ DPRA + L + L HS V L D+ IIS S D T+++ D
Sbjct: 434 WDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWD 484
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 69.3 bits (168), Expect = 7e-12
Identities = 93/421 (22%), Positives = 173/421 (41%), Gaps = 60/421 (14%)
Query: 71 VSAVSEPGLLSLPPELLLEICSYLDARLVLHVLSRVCHALRDLVSDHVTWRLRALRRVRA 130
++A+ E GL + +L SYLDAR L VC + ++S+ + W+ R VR
Sbjct: 107 ITALPEQGLDHIAENIL----SYLDARS-LCAAELVCKEWQRVISEGMLWKKLIERMVRT 161
Query: 131 P---YPVVEEKNFD--------------------WPAACIALEQHLSRWAEDGRWVEYF- 166
+ E + +D +P +E S W ++
Sbjct: 162 DPLWKGLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQ 221
Query: 167 CLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHE 226
C +E S L +SG RD ++ +WD L E +VL + H
Sbjct: 222 CRSEN---SKGVYCLQYDDEKIISGLRDNSIKIWDKTSL--ECLKVL---------TGHT 267
Query: 227 GWVWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDK 286
G V L + + +GS DSTV++WD+ I + AVL L + ++VT + D+
Sbjct: 268 GSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDR 327
Query: 287 KVTIYDPRAGPALLKHQQL--HSRPVLTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQ 344
+ ++D + + + L H V + DD++I+S S D T+ V ++ L
Sbjct: 328 SIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLN 387
Query: 345 LDSY-LLCMSYQEPQLWAGDNQGLLHVFANRNG-CFQLIRSFDVGHSFPITGIQYSVGAL 402
+ C+ Y++ + +G + + ++ G C +++ GH + I++ +
Sbjct: 388 GHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLE----GHEELVRCIRFDNKRI 443
Query: 403 YTTSTDKTIRVH------VPTDPPRTICTR---RHDNGLNRVCAEGNLVVAGSGDLSLEV 453
+ + D I+V P P T+C R H + R+ + +++ S D ++ +
Sbjct: 444 VSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILI 503
Query: 454 W 454
W
Sbjct: 504 W 504
Score = 61.6 bits (148), Expect = 1e-09
Identities = 59/239 (24%), Positives = 111/239 (46%), Gaps = 18/239 (7%)
Query: 229 VWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKV 288
V+ L D ++ SG D+++K+WD + + +VLCL Y ++VTG+ D V
Sbjct: 230 VYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTV 289
Query: 289 TIYDPRAGPAL--LKHQQLHSRPVLTLLADDRHIISGSEDHTLVVVD-RRANSVLQRLQL 345
++D G L L H H+ VL L + +++ S+D ++ V D A + R L
Sbjct: 290 RVWDVNTGEVLNTLIH---HNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVL 346
Query: 346 DSYLLCMS---YQEPQLWAGDNQGLLHVFANRNGCFQLIRSFDVGHSFPITGIQYSVGAL 402
+ ++ + + + + + V++ + +R+ + GH I +QY +
Sbjct: 347 VGHRAAVNVVDFDDKYIVSASGDRTIKVWS--TSTCEFVRTLN-GHKRGIACLQYRDRLV 403
Query: 403 YTTSTDKTIRVHVPTDPPRTICTR---RHDNGLNRVCAEGNLVVAGSGDLSLEVWRLQA 458
+ S+D TIR+ D C R H+ + + + +V+G+ D ++VW LQA
Sbjct: 404 VSGSSDNTIRL---WDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQA 459
Score = 58.2 bits (139), Expect = 2e-08
Identities = 47/193 (24%), Positives = 84/193 (43%), Gaps = 2/193 (1%)
Query: 266 SSAVLCLSYLPDILVTGTYDKKVTIYDPRAGPALLKHQQLHSRPVLTLLADDRHIISGSE 325
S V CL Y + +++G D + I+D + LK H+ VL L D+R I++GS
Sbjct: 227 SKGVYCLQYDDEKIISGLRDNSIKIWD-KTSLECLKVLTGHTGSVLCLQYDERVIVTGSS 285
Query: 326 DHTLVVVDRRANSVLQRL-QLDSYLLCMSYQEPQLWAGDNQGLLHVFANRNGCFQLIRSF 384
D T+ V D VL L + +L + + + + V+ + +R
Sbjct: 286 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRV 345
Query: 385 DVGHSFPITGIQYSVGALYTTSTDKTIRVHVPTDPPRTICTRRHDNGLNRVCAEGNLVVA 444
VGH + + + + + S D+TI+V + H G+ + LVV+
Sbjct: 346 LVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVS 405
Query: 445 GSGDLSLEVWRLQ 457
GS D ++ +W ++
Sbjct: 406 GSSDNTIRLWDIE 418
Score = 57.0 bits (136), Expect = 3e-08
Identities = 50/171 (29%), Positives = 79/171 (46%), Gaps = 21/171 (12%)
Query: 171 GHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVW 230
GH A+V+ V +S S DR + +W + S ++TL + H+ +
Sbjct: 348 GHRAAVNVVDF--DDKYIVSASGDRTIKVW------STSTCEFVRTL-----NGHKRGIA 394
Query: 231 SLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKVTI 290
L +D V SGS D+T++LWD+ V C+ + +V+G YD K+ +
Sbjct: 395 CLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 454
Query: 291 Y------DPRAGPALLKHQQL--HSRPVLTLLADDRHIISGSEDHTLVVVD 333
+ DPRA + L + L HS V L D+ IIS S D T+++ D
Sbjct: 455 WDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWD 505
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 66.6 bits (161), Expect = 4e-11
Identities = 64/279 (22%), Positives = 124/279 (44%), Gaps = 28/279 (10%)
Query: 189 LSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWSLAAQDHRVCSGSWDSTV 248
+SG RD + +WD L E ++L + H G V L + + +GS DSTV
Sbjct: 281 VSGLRDNTIKIWDKNTL--ECKRIL---------TGHTGSVLCLQYDERVIITGSSDSTV 329
Query: 249 KLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKVTIYDPRAGPALLKHQQL--H 306
++WD+ I AVL L + ++VT + D+ + ++D + + + L H
Sbjct: 330 RVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGH 389
Query: 307 SRPVLTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQLDSY-LLCMSYQEPQLWAGDNQ 365
V + DD++I+S S D T+ V + ++ L + C+ Y++ + +G +
Sbjct: 390 RAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSD 449
Query: 366 GLLHVFANRNG-CFQLIRSFDVGHSFPITGIQYSVGALYTTSTDKTIRVH------VPTD 418
+ ++ G C +++ GH + I++ + + + D I+V P
Sbjct: 450 NTIRLWDIECGACLRVLE----GHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRA 505
Query: 419 PPRTICTR---RHDNGLNRVCAEGNLVVAGSGDLSLEVW 454
P T+C R H + R+ + +V+ S D ++ +W
Sbjct: 506 PAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIW 544
Score = 62.4 bits (150), Expect = 8e-10
Identities = 62/247 (25%), Positives = 120/247 (48%), Gaps = 19/247 (7%)
Query: 221 RNSTHEGWVWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILV 280
R+ T +G V+ L D ++ SG D+T+K+WD + + +VLCL Y +++
Sbjct: 263 RSETSKG-VYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVII 321
Query: 281 TGTYDKKVTIYDPRAGPAL--LKHQQLHSRPVLTLLADDRHIISGSEDHTLVVVDRRA-- 336
TG+ D V ++D G L L H H VL L ++ +++ S+D ++ V D +
Sbjct: 322 TGSSDSTVRVWDVNTGEMLNTLIH---HCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPT 378
Query: 337 NSVLQRLQLD--SYLLCMSYQEPQLWAGDNQGLLHVFANRNGCFQLIRSFDVGHSFPITG 394
+ L+R+ + + + + + + + + + V+ N + C + +R+ + GH I
Sbjct: 379 DITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW-NTSTC-EFVRTLN-GHKRGIAC 435
Query: 395 IQYSVGALYTTSTDKTIRVHVPTDPPRTICTR---RHDNGLNRVCAEGNLVVAGSGDLSL 451
+QY + + S+D TIR+ D C R H+ + + + +V+G+ D +
Sbjct: 436 LQYRDRLVVSGSSDNTIRL---WDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKI 492
Query: 452 EVWRLQA 458
+VW L A
Sbjct: 493 KVWDLVA 499
Score = 42.0 bits (97), Expect = 0.001
Identities = 38/147 (25%), Positives = 58/147 (39%), Gaps = 43/147 (29%)
Query: 187 LCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWSLAAQDHRVCSGSWDS 246
L +SGS D + LWD+ E L G HE V + + R+ SG++D
Sbjct: 442 LVVSGSSDNTIRLWDI-----ECGACLRVLEG------HEELVRCIRFDNKRIVSGAYDG 490
Query: 247 TVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKVTIYDPRAGPALLKHQQLH 306
+K+WD+ A + +A + LCL L + H
Sbjct: 491 KIKVWDLVA----ALDPRAPAGTLCLRTLVE----------------------------H 518
Query: 307 SRPVLTLLADDRHIISGSEDHTLVVVD 333
S V L D+ I+S S D T+++ D
Sbjct: 519 SGRVFRLQFDEFQIVSSSHDDTILIWD 545
Score = 34.3 bits (77), Expect = 0.24
Identities = 19/68 (27%), Positives = 32/68 (47%), Gaps = 2/68 (2%)
Query: 189 LSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWSLAAQDHRVCSGSWDSTV 248
+SG+ D + +WDL + + TL + H G V+ L + ++ S S D T+
Sbjct: 484 VSGAYDGKIKVWDL--VAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTI 541
Query: 249 KLWDMAAD 256
+WD D
Sbjct: 542 LIWDFLND 549
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 66.6 bits (161), Expect = 4e-11
Identities = 64/279 (22%), Positives = 124/279 (44%), Gaps = 28/279 (10%)
Query: 189 LSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWSLAAQDHRVCSGSWDSTV 248
+SG RD + +WD L E ++L + H G V L + + +GS DSTV
Sbjct: 317 VSGLRDNTIKIWDKNTL--ECKRIL---------TGHTGSVLCLQYDERVIITGSSDSTV 365
Query: 249 KLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKVTIYDPRAGPALLKHQQL--H 306
++WD+ I AVL L + ++VT + D+ + ++D + + + L H
Sbjct: 366 RVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGH 425
Query: 307 SRPVLTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQLDSY-LLCMSYQEPQLWAGDNQ 365
V + DD++I+S S D T+ V + ++ L + C+ Y++ + +G +
Sbjct: 426 RAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSD 485
Query: 366 GLLHVFANRNG-CFQLIRSFDVGHSFPITGIQYSVGALYTTSTDKTIRVH------VPTD 418
+ ++ G C +++ GH + I++ + + + D I+V P
Sbjct: 486 NTIRLWDIECGACLRVLE----GHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRA 541
Query: 419 PPRTICTR---RHDNGLNRVCAEGNLVVAGSGDLSLEVW 454
P T+C R H + R+ + +V+ S D ++ +W
Sbjct: 542 PAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIW 580
Score = 62.4 bits (150), Expect = 8e-10
Identities = 62/247 (25%), Positives = 120/247 (48%), Gaps = 19/247 (7%)
Query: 221 RNSTHEGWVWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILV 280
R+ T +G V+ L D ++ SG D+T+K+WD + + +VLCL Y +++
Sbjct: 299 RSETSKG-VYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVII 357
Query: 281 TGTYDKKVTIYDPRAGPAL--LKHQQLHSRPVLTLLADDRHIISGSEDHTLVVVDRRA-- 336
TG+ D V ++D G L L H H VL L ++ +++ S+D ++ V D +
Sbjct: 358 TGSSDSTVRVWDVNTGEMLNTLIH---HCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPT 414
Query: 337 NSVLQRLQLD--SYLLCMSYQEPQLWAGDNQGLLHVFANRNGCFQLIRSFDVGHSFPITG 394
+ L+R+ + + + + + + + + + V+ N + C + +R+ + GH I
Sbjct: 415 DITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW-NTSTC-EFVRTLN-GHKRGIAC 471
Query: 395 IQYSVGALYTTSTDKTIRVHVPTDPPRTICTR---RHDNGLNRVCAEGNLVVAGSGDLSL 451
+QY + + S+D TIR+ D C R H+ + + + +V+G+ D +
Sbjct: 472 LQYRDRLVVSGSSDNTIRL---WDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKI 528
Query: 452 EVWRLQA 458
+VW L A
Sbjct: 529 KVWDLVA 535
Score = 42.0 bits (97), Expect = 0.001
Identities = 38/147 (25%), Positives = 58/147 (39%), Gaps = 43/147 (29%)
Query: 187 LCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWSLAAQDHRVCSGSWDS 246
L +SGS D + LWD+ E L G HE V + + R+ SG++D
Sbjct: 478 LVVSGSSDNTIRLWDI-----ECGACLRVLEG------HEELVRCIRFDNKRIVSGAYDG 526
Query: 247 TVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKVTIYDPRAGPALLKHQQLH 306
+K+WD+ A + +A + LCL L + H
Sbjct: 527 KIKVWDLVA----ALDPRAPAGTLCLRTLVE----------------------------H 554
Query: 307 SRPVLTLLADDRHIISGSEDHTLVVVD 333
S V L D+ I+S S D T+++ D
Sbjct: 555 SGRVFRLQFDEFQIVSSSHDDTILIWD 581
Score = 34.3 bits (77), Expect = 0.24
Identities = 19/68 (27%), Positives = 32/68 (47%), Gaps = 2/68 (2%)
Query: 189 LSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWSLAAQDHRVCSGSWDSTV 248
+SG+ D + +WDL + + TL + H G V+ L + ++ S S D T+
Sbjct: 520 VSGAYDGKIKVWDL--VAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTI 577
Query: 249 KLWDMAAD 256
+WD D
Sbjct: 578 LIWDFLND 585
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 63.9 bits (154), Expect = 3e-10
Identities = 64/270 (23%), Positives = 112/270 (41%), Gaps = 23/270 (8%)
Query: 149 LEQHLSRWAEDGRWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTE 208
+++ + W G E+ G A + S+ GS L+ S D +W T
Sbjct: 342 MDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIW------TV 395
Query: 209 SNQVLIKTLGTKRNSTHEGWVWS--LAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKAS 266
+ L TL + H G V S + R+ SGS D T+KLWD+ + + A
Sbjct: 396 DDYRLRHTL-----TGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSK-VCIKTVFAG 449
Query: 267 SAVLCLSYLPDILVTGTYDKKVTIYDPRAGPALLKHQQLHSRPVLTLLADDRHIISGSED 326
S+ + +++G +DKK+ +D R+ + + + L L L + ++S S D
Sbjct: 450 SSCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRD 509
Query: 327 HTLVVVDRRANSVLQRLQLDSY-------LLCMSYQEPQLWAGDNQGLLHVFANRNGCFQ 379
L V+D R N++ Q + + S + AG +G L++++ G +
Sbjct: 510 DLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVE 569
Query: 380 LIRSFDVGHSFPITGIQYSVGALYTTSTDK 409
+ S HS I + +S + S DK
Sbjct: 570 KVLSKQ--HSSSINAVAWSPSGSHVVSVDK 597
Score = 32.3 bits (72), Expect = 0.92
Identities = 33/110 (30%), Positives = 54/110 (49%), Gaps = 19/110 (17%)
Query: 239 VCSGSWDSTVKLWDMAADGQQF-GEIKASSAVLCL-------SYLPDILVTGTYDKKV-T 289
+ +G D VKLW++ + +F G + S+A + SYL + + + ++ T
Sbjct: 337 LATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYL--LAASNDFASRIWT 394
Query: 290 IYDPRAGPALLKHQQL-HSRPVLT--LLADDRHIISGSEDHTLVVVDRRA 336
+ D R L+H HS VL+ L D+ I+SGS D TL + D R+
Sbjct: 395 VDDYR-----LRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS 439
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 63.9 bits (154), Expect = 3e-10
Identities = 64/270 (23%), Positives = 112/270 (41%), Gaps = 23/270 (8%)
Query: 149 LEQHLSRWAEDGRWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTE 208
+++ + W G E+ G A + S+ GS L+ S D +W T
Sbjct: 323 MDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIW------TV 376
Query: 209 SNQVLIKTLGTKRNSTHEGWVWS--LAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKAS 266
+ L TL + H G V S + R+ SGS D T+KLWD+ + + A
Sbjct: 377 DDYRLRHTL-----TGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSK-VCIKTVFAG 430
Query: 267 SAVLCLSYLPDILVTGTYDKKVTIYDPRAGPALLKHQQLHSRPVLTLLADDRHIISGSED 326
S+ + +++G +DKK+ +D R+ + + + L L L + ++S S D
Sbjct: 431 SSCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRD 490
Query: 327 HTLVVVDRRANSVLQRLQLDSY-------LLCMSYQEPQLWAGDNQGLLHVFANRNGCFQ 379
L V+D R N++ Q + + S + AG +G L++++ G +
Sbjct: 491 DLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVE 550
Query: 380 LIRSFDVGHSFPITGIQYSVGALYTTSTDK 409
+ S HS I + +S + S DK
Sbjct: 551 KVLSKQ--HSSSINAVAWSPSGSHVVSVDK 578
Score = 32.3 bits (72), Expect = 0.92
Identities = 33/110 (30%), Positives = 54/110 (49%), Gaps = 19/110 (17%)
Query: 239 VCSGSWDSTVKLWDMAADGQQF-GEIKASSAVLCL-------SYLPDILVTGTYDKKV-T 289
+ +G D VKLW++ + +F G + S+A + SYL + + + ++ T
Sbjct: 318 LATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYL--LAASNDFASRIWT 375
Query: 290 IYDPRAGPALLKHQQL-HSRPVLT--LLADDRHIISGSEDHTLVVVDRRA 336
+ D R L+H HS VL+ L D+ I+SGS D TL + D R+
Sbjct: 376 VDDYR-----LRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS 420
>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
Length = 423
Score = 62.4 bits (150), Expect = 8e-10
Identities = 57/207 (27%), Positives = 90/207 (43%), Gaps = 24/207 (11%)
Query: 153 LSRWAEDGRWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLW--------DLRQ 204
L W + V+ GH SVDS+ + G+ SGS D+ + +W D +
Sbjct: 169 LWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEME 228
Query: 205 LGTESNQVLIKT--LGTKRN-----STHEGWVWSLAAQD-HRVCSGSWDSTVKLWDMAAD 256
T + KT LG R S H V S+ D +CS SWD T+++WD+ +
Sbjct: 229 ESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVES- 287
Query: 257 GQQFGEIKASSAVLCLSYLP--DILVTGTYDKKVTIYDPRAGPALLKHQQLHSR-----P 309
G + + C+SY P L +G+ D+ + ++DPR L L S
Sbjct: 288 GSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTS 347
Query: 310 VLTLLADDRHIISGSEDHTLVVVDRRA 336
V ++ +ISGS D+ + + D R+
Sbjct: 348 VKWSPTHEQQLISGSLDNIVKLWDTRS 374
Score = 29.3 bits (64), Expect = 7.8
Identities = 8/29 (27%), Positives = 18/29 (62%)
Query: 225 HEGWVWSLAAQDHRVCSGSWDSTVKLWDM 253
H+ W+ S+ + + +GS+D T ++W +
Sbjct: 100 HDDWISSIKGAEEWILTGSYDKTSRIWSL 128
>gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens]
Length = 619
Score = 61.6 bits (148), Expect = 1e-09
Identities = 56/221 (25%), Positives = 91/221 (41%), Gaps = 50/221 (22%)
Query: 170 EGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVL---------------- 213
+ H++ V++V SL +G DR ++LW++ E+NQ L
Sbjct: 333 DAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSG 392
Query: 214 IKTLGTKRNSTHEGWVWSLAAQD-------------------HRVCSGSWDSTVKLWDMA 254
+ L N + W A H+ +GS D TVK WD+
Sbjct: 393 YQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDL- 451
Query: 255 ADGQQFGEIKASSAVLCLSYLPD------ILVTGTYDKKVTIYDPRAGPALLKHQQLHSR 308
G S + LSY D I+++G D+K+ +D R GP + + R
Sbjct: 452 ------GRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSR-GPHCTQVIPVQGR 504
Query: 309 PV-LTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQLDSY 348
L+L D H++S S D+TL V+D R +++ Q + D +
Sbjct: 505 VTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGF 545
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 60.1 bits (144), Expect = 4e-09
Identities = 51/165 (30%), Positives = 80/165 (48%), Gaps = 18/165 (10%)
Query: 171 GHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVW 230
GH + V+SV L L ++GS+ ++ +WDL E+ ++L +G K N +
Sbjct: 61 GHTSPVESVRLNTPEELIVAGSQSGSIRVWDL-----EAAKILRTLMGHKAN------IC 109
Query: 231 SLAAQDHR--VCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPD--ILVTGTYDK 286
SL + V SGS D+ +KLWD+ G F S AV CL + PD L + D
Sbjct: 110 SLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDH 169
Query: 287 KVTIYDPRAGPALLKHQQLHSRP--VLTLLADDRHIISGSEDHTL 329
V ++D AG ++ H+ P V+ ++ + SGS D T+
Sbjct: 170 TVKLWDLTAG-KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTI 213
>gi|31543297 neutral sphingomyelinase (N-SMase) activation
associated factor isoform 1 [Homo sapiens]
Length = 917
Score = 57.0 bits (136), Expect = 3e-08
Identities = 55/211 (26%), Positives = 91/211 (43%), Gaps = 27/211 (12%)
Query: 175 SVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWSLAA 234
++ S LLL G + ++ S D NV + + G + ++ H+ V +
Sbjct: 674 ALSSCLLLPGDATVITSSWDNNVYFYSIA-FGRRQDTLM----------GHDDAVSKICW 722
Query: 235 QDHRVCSGSWDSTVKLW-----DMAADGQQFGEIKA------SSAVLCLSYLPDILVTGT 283
D+R+ S SWDSTVK+W +M + ++ A S + L+ +LV+GT
Sbjct: 723 HDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGT 782
Query: 284 YDKKVTIYDPRAGPALLKHQ-QLHSRPV--LTLLADDRHIISGSEDHTLVVVDRRANSVL 340
+ V I+D A L HQ HS V D RH++S D L V+D + ++
Sbjct: 783 KEGTVNIWD--LTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLI 840
Query: 341 QRLQLDSYLLCMSYQEPQLWAGDNQGLLHVF 371
+ D C + + +G G L V+
Sbjct: 841 SSMTSDEPQRCFVWDGNSVLSGSQSGELLVW 871
Score = 39.7 bits (91), Expect = 0.006
Identities = 32/118 (27%), Positives = 55/118 (46%), Gaps = 8/118 (6%)
Query: 231 SLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLC-LSYLPD---ILVTGTYDK 286
SL A + SG+ + TV +WD+ +I S ++C ++ PD +L TGT D
Sbjct: 770 SLNAASTLLVSGTKEGTVNIWDLTT-ATLMHQIPCHSGIVCDTAFSPDSRHVLSTGT-DG 827
Query: 287 KVTIYDPRAGPALLKHQQLHSRPVLTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQ 344
+ + D + G +L P + D ++SGS+ L+V D + +R+Q
Sbjct: 828 CLNVIDVQTG--MLISSMTSDEPQRCFVWDGNSVLSGSQSGELLVWDLLGAKISERIQ 883
Score = 37.0 bits (84), Expect = 0.037
Identities = 36/163 (22%), Positives = 71/163 (43%), Gaps = 17/163 (10%)
Query: 172 HVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWS 231
H SVD++ L +L +SG+++ VN+WDL T +Q+ H G V
Sbjct: 762 HDVSVDTISLNAASTLLVSGTKEGTVNIWDL-TTATLMHQI----------PCHSGIVCD 810
Query: 232 LA--AQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKVT 289
A V S D + + D+ G + + C + + +++G+ ++
Sbjct: 811 TAFSPDSRHVLSTGTDGCLNVIDVQT-GMLISSMTSDEPQRCFVWDGNSVLSGSQSGELL 869
Query: 290 IYDPRAGPALLKHQQLHSRPVLTLLADDR--HIISGSEDHTLV 330
++D G + + Q H+ V + +++ II+G ED ++
Sbjct: 870 VWD-LLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQII 911
Score = 33.9 bits (76), Expect = 0.32
Identities = 37/175 (21%), Positives = 77/175 (44%), Gaps = 21/175 (12%)
Query: 299 LLKHQQLHSRPV--LTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQLDSYLLCMSYQE 356
L +H ++H V +T+ + + + S+D TL + + + + + + + M+
Sbjct: 622 LHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSN----MALSS 677
Query: 357 PQLWAGDNQGLLHVFANRNGCFQLI--RSFD--VGHSFPITGIQYSVGALYTTSTDKTIR 412
L GD + + N + + R D +GH ++ I + LY+ S D T++
Sbjct: 678 CLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVK 737
Query: 413 V--HVPTDPPRT-------ICTRRHDNGLNRVC--AEGNLVVAGSGDLSLEVWRL 456
V VP + P T + HD ++ + A L+V+G+ + ++ +W L
Sbjct: 738 VWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDL 792
>gi|221625547 neutral sphingomyelinase (N-SMase) activation
associated factor isoform 2 [Homo sapiens]
Length = 948
Score = 57.0 bits (136), Expect = 3e-08
Identities = 55/211 (26%), Positives = 91/211 (43%), Gaps = 27/211 (12%)
Query: 175 SVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWSLAA 234
++ S LLL G + ++ S D NV + + G + ++ H+ V +
Sbjct: 705 ALSSCLLLPGDATVITSSWDNNVYFYSIA-FGRRQDTLM----------GHDDAVSKICW 753
Query: 235 QDHRVCSGSWDSTVKLW-----DMAADGQQFGEIKA------SSAVLCLSYLPDILVTGT 283
D+R+ S SWDSTVK+W +M + ++ A S + L+ +LV+GT
Sbjct: 754 HDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGT 813
Query: 284 YDKKVTIYDPRAGPALLKHQ-QLHSRPV--LTLLADDRHIISGSEDHTLVVVDRRANSVL 340
+ V I+D A L HQ HS V D RH++S D L V+D + ++
Sbjct: 814 KEGTVNIWD--LTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLI 871
Query: 341 QRLQLDSYLLCMSYQEPQLWAGDNQGLLHVF 371
+ D C + + +G G L V+
Sbjct: 872 SSMTSDEPQRCFVWDGNSVLSGSQSGELLVW 902
Score = 39.7 bits (91), Expect = 0.006
Identities = 32/118 (27%), Positives = 55/118 (46%), Gaps = 8/118 (6%)
Query: 231 SLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLC-LSYLPD---ILVTGTYDK 286
SL A + SG+ + TV +WD+ +I S ++C ++ PD +L TGT D
Sbjct: 801 SLNAASTLLVSGTKEGTVNIWDLTT-ATLMHQIPCHSGIVCDTAFSPDSRHVLSTGT-DG 858
Query: 287 KVTIYDPRAGPALLKHQQLHSRPVLTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQ 344
+ + D + G +L P + D ++SGS+ L+V D + +R+Q
Sbjct: 859 CLNVIDVQTG--MLISSMTSDEPQRCFVWDGNSVLSGSQSGELLVWDLLGAKISERIQ 914
Score = 37.0 bits (84), Expect = 0.037
Identities = 36/163 (22%), Positives = 71/163 (43%), Gaps = 17/163 (10%)
Query: 172 HVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWS 231
H SVD++ L +L +SG+++ VN+WDL T +Q+ H G V
Sbjct: 793 HDVSVDTISLNAASTLLVSGTKEGTVNIWDL-TTATLMHQI----------PCHSGIVCD 841
Query: 232 LA--AQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKVT 289
A V S D + + D+ G + + C + + +++G+ ++
Sbjct: 842 TAFSPDSRHVLSTGTDGCLNVIDVQT-GMLISSMTSDEPQRCFVWDGNSVLSGSQSGELL 900
Query: 290 IYDPRAGPALLKHQQLHSRPVLTLLADDR--HIISGSEDHTLV 330
++D G + + Q H+ V + +++ II+G ED ++
Sbjct: 901 VWD-LLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQII 942
Score = 33.9 bits (76), Expect = 0.32
Identities = 37/175 (21%), Positives = 77/175 (44%), Gaps = 21/175 (12%)
Query: 299 LLKHQQLHSRPV--LTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQLDSYLLCMSYQE 356
L +H ++H V +T+ + + + S+D TL + + + + + + + M+
Sbjct: 653 LHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSN----MALSS 708
Query: 357 PQLWAGDNQGLLHVFANRNGCFQLI--RSFD--VGHSFPITGIQYSVGALYTTSTDKTIR 412
L GD + + N + + R D +GH ++ I + LY+ S D T++
Sbjct: 709 CLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVK 768
Query: 413 V--HVPTDPPRT-------ICTRRHDNGLNRVC--AEGNLVVAGSGDLSLEVWRL 456
V VP + P T + HD ++ + A L+V+G+ + ++ +W L
Sbjct: 769 VWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDL 823
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 56.2 bits (134), Expect = 6e-08
Identities = 49/182 (26%), Positives = 81/182 (44%), Gaps = 16/182 (8%)
Query: 167 CLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHE 226
C GH +V SV G S S DR + +W G + G +
Sbjct: 35 CTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW-----GAYDGKYEKTLYGHNLEISDV 89
Query: 227 GWVWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKA-SSAVLCLSYLP--DILVTGT 283
W ++ R+ S S D T+KLWD+ + G+ +K S+ V C ++ P +++++G+
Sbjct: 90 AW----SSDSSRLVSASDDKTLKLWDVRS-GKCLKTLKGHSNYVFCCNFNPPSNLIISGS 144
Query: 284 YDKKVTIYDPRAGPALLKHQQLHSRPV--LTLLADDRHIISGSEDHTLVVVDRRANSVLQ 341
+D+ V I++ + G LK HS PV + I+SGS D + D + L+
Sbjct: 145 FDETVKIWEVKTGKC-LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK 203
Query: 342 RL 343
L
Sbjct: 204 TL 205
Score = 43.9 bits (102), Expect = 3e-04
Identities = 54/256 (21%), Positives = 99/256 (38%), Gaps = 63/256 (24%)
Query: 139 NFDWPAACIALEQHLSRWAEDGRWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVN 198
N +W A+ A + A DG++ + GH + V S +S S D+ +
Sbjct: 52 NGEWLASSSADRLIIIWGAYDGKYEKTLY---GHNLEISDVAWSSDSSRLVSASDDKTLK 108
Query: 199 LWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWSLAAQDHRVCSGSWDSTVKLWDMAADGQ 258
LWD+R K L T + ++ + + + + SGS+D TVK+W++ G+
Sbjct: 109 LWDVRSG---------KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT-GK 158
Query: 259 QFGEIKASS---AVLCLSYLPDILVTGTYDKKVTIYDPRAGPALLKHQQLHSRPV----- 310
+ A S + + + ++V+G+YD I+D +G L + PV
Sbjct: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF 218
Query: 311 -------LTLLADD-----------------------------------RHIISGSEDHT 328
LT D+ + I+SGSED+
Sbjct: 219 SPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 278
Query: 329 LVVVDRRANSVLQRLQ 344
+ + + + ++Q+LQ
Sbjct: 279 VYIWNLQTKEIVQKLQ 294
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 55.8 bits (133), Expect = 8e-08
Identities = 51/183 (27%), Positives = 85/183 (46%), Gaps = 17/183 (9%)
Query: 166 FCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTH 225
F LA GH +V SV G S S D+ + +W G + G K +
Sbjct: 39 FTLA-GHTKAVSSVKFSPNGEWLASSSADKLIKIW-----GAYDGKFEKTISGHKLGISD 92
Query: 226 EGWVWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKA-SSAVLCLSYLP--DILVTG 282
W ++ + + S S D T+K+WD+++ G+ +K S+ V C ++ P +++V+G
Sbjct: 93 VAW----SSDSNLLVSASDDKTLKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147
Query: 283 TYDKKVTIYDPRAGPALLKHQQLHSRPV--LTLLADDRHIISGSEDHTLVVVDRRANSVL 340
++D+ V I+D + G LK HS PV + D I+S S D + D + L
Sbjct: 148 SFDESVRIWDVKTGKC-LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206
Query: 341 QRL 343
+ L
Sbjct: 207 KTL 209
Score = 48.1 bits (113), Expect = 2e-05
Identities = 50/203 (24%), Positives = 97/203 (47%), Gaps = 24/203 (11%)
Query: 139 NFDWPAACIALEQHLSRW-AEDGRWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNV 197
N +W A+ A ++ + W A DG++ + GH + V +L +S S D+ +
Sbjct: 56 NGEWLASSSA-DKLIKIWGAYDGKFEKTI---SGHKLGISDVAWSSDSNLLVSASDDKTL 111
Query: 198 NLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVW--SLAAQDHRVCSGSWDSTVKLWDMAA 255
+WD+ S+ +KTL H +V+ + Q + + SGS+D +V++WD+
Sbjct: 112 KIWDV------SSGKCLKTL-----KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 256 DGQQFGEIKA-SSAVLCLSYLPD--ILVTGTYDKKVTIYDPRAGPALLKHQQLHSRPV-- 310
G+ + A S V + + D ++V+ +YD I+D +G L + PV
Sbjct: 161 -GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219
Query: 311 LTLLADDRHIISGSEDHTLVVVD 333
+ + ++I++ + D+TL + D
Sbjct: 220 VKFSPNGKYILAATLDNTLKLWD 242
Score = 31.2 bits (69), Expect = 2.0
Identities = 19/72 (26%), Positives = 38/72 (52%), Gaps = 4/72 (5%)
Query: 387 GHSFPITGIQYSVGA--LYTTSTDKTIRVHVPTDPPRTICTRRHDNGLNRVC--AEGNLV 442
GH+ ++ +++S L ++S DK I++ D H G++ V ++ NL+
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 443 VAGSGDLSLEVW 454
V+ S D +L++W
Sbjct: 103 VSASDDKTLKIW 114
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 55.8 bits (133), Expect = 8e-08
Identities = 51/183 (27%), Positives = 85/183 (46%), Gaps = 17/183 (9%)
Query: 166 FCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTH 225
F LA GH +V SV G S S D+ + +W G + G K +
Sbjct: 39 FTLA-GHTKAVSSVKFSPNGEWLASSSADKLIKIW-----GAYDGKFEKTISGHKLGISD 92
Query: 226 EGWVWSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKA-SSAVLCLSYLP--DILVTG 282
W ++ + + S S D T+K+WD+++ G+ +K S+ V C ++ P +++V+G
Sbjct: 93 VAW----SSDSNLLVSASDDKTLKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147
Query: 283 TYDKKVTIYDPRAGPALLKHQQLHSRPV--LTLLADDRHIISGSEDHTLVVVDRRANSVL 340
++D+ V I+D + G LK HS PV + D I+S S D + D + L
Sbjct: 148 SFDESVRIWDVKTGKC-LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206
Query: 341 QRL 343
+ L
Sbjct: 207 KTL 209
Score = 48.1 bits (113), Expect = 2e-05
Identities = 50/203 (24%), Positives = 97/203 (47%), Gaps = 24/203 (11%)
Query: 139 NFDWPAACIALEQHLSRW-AEDGRWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNV 197
N +W A+ A ++ + W A DG++ + GH + V +L +S S D+ +
Sbjct: 56 NGEWLASSSA-DKLIKIWGAYDGKFEKTI---SGHKLGISDVAWSSDSNLLVSASDDKTL 111
Query: 198 NLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVW--SLAAQDHRVCSGSWDSTVKLWDMAA 255
+WD+ S+ +KTL H +V+ + Q + + SGS+D +V++WD+
Sbjct: 112 KIWDV------SSGKCLKTL-----KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 256 DGQQFGEIKA-SSAVLCLSYLPD--ILVTGTYDKKVTIYDPRAGPALLKHQQLHSRPV-- 310
G+ + A S V + + D ++V+ +YD I+D +G L + PV
Sbjct: 161 -GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219
Query: 311 LTLLADDRHIISGSEDHTLVVVD 333
+ + ++I++ + D+TL + D
Sbjct: 220 VKFSPNGKYILAATLDNTLKLWD 242
Score = 31.2 bits (69), Expect = 2.0
Identities = 19/72 (26%), Positives = 38/72 (52%), Gaps = 4/72 (5%)
Query: 387 GHSFPITGIQYSVGA--LYTTSTDKTIRVHVPTDPPRTICTRRHDNGLNRVC--AEGNLV 442
GH+ ++ +++S L ++S DK I++ D H G++ V ++ NL+
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 443 VAGSGDLSLEVW 454
V+ S D +L++W
Sbjct: 103 VSASDDKTLKIW 114
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 55.5 bits (132), Expect = 1e-07
Identities = 53/165 (32%), Positives = 77/165 (46%), Gaps = 33/165 (20%)
Query: 171 GHVASVDSVLLLQGGSLCL-SGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWV 229
GH V + GSL L S SRD+ + +WDL + G + QVL S H WV
Sbjct: 151 GHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQI-QVL---------SGHLQWV 200
Query: 230 W--SLAAQDHRVCSGSWDSTVKLWDMAA-------DGQQFGEIKASSAVLCLSYLPD--I 278
+ S++ +CS + + +V LW M + +G Q S+V+ + PD +
Sbjct: 201 YCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQ-------SSVVSCDFSPDSAL 253
Query: 279 LVTGTYDKKVTIYDPRAGPALLKHQQLHSRPVLTLLAD-DRHIIS 322
LVT +YD V ++DP G L + LH V + D D HI S
Sbjct: 254 LVTASYDTNVIMWDPYTGERL---RSLHHTQVDPAMDDSDVHISS 295
>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
Length = 670
Score = 55.1 bits (131), Expect = 1e-07
Identities = 71/298 (23%), Positives = 131/298 (43%), Gaps = 37/298 (12%)
Query: 171 GHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVW 230
GH V + + G L SGS D+ + +WD T + KTL H+G V
Sbjct: 394 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWD-----TCTTYKCQKTL-----EGHDGIVL 443
Query: 231 SLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLC-LSYLPDILVTGTYDKKVT 289
+L Q ++ SGS D T+ +WD+ + Q+ I+A +C L ++L +G+ K +
Sbjct: 444 ALCIQGCKLYSGSADCTIIVWDI-QNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL-KAIK 501
Query: 290 IYDPRAGPALLKHQQLH-SRPVLTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQLD-S 347
++D LK + + V L+A ++ SGS T+ + D R + LQ
Sbjct: 502 VWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSY-QTIKIWDIRTLDCIHVLQTSGG 560
Query: 348 YLLCMSYQEPQLWAGDNQGLLHVFANRNGCFQLIRSFDVGHSFPITGIQYSVGAL----- 402
+ ++ + G + L+HV+ + + +R+ GH G Y++ +
Sbjct: 561 SVYSIAVTNHHIVCGTYENLIHVWDIESK--EQVRTL-TGH----VGTVYALAVISTPDQ 613
Query: 403 ---YTTSTDKTIRVHVPTDPPRTICTR---RHDNGLNRVCAEGNLVVAGSGDLSLEVW 454
++ S D+++RV ICT+ RH + + + +G+ D +++VW
Sbjct: 614 TKVFSASYDRSLRV---WSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
Score = 35.0 bits (79), Expect = 0.14
Identities = 25/75 (33%), Positives = 41/75 (54%), Gaps = 3/75 (4%)
Query: 386 VGHSFPITGI-QYSVG-ALYTTSTDKTIRVHVPTDPPRTICTRR-HDNGLNRVCAEGNLV 442
VGH P+ + YS+G L++ S+DKTI+V + T HD + +C +G +
Sbjct: 393 VGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKL 452
Query: 443 VAGSGDLSLEVWRLQ 457
+GS D ++ VW +Q
Sbjct: 453 YSGSADCTIIVWDIQ 467
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 55.1 bits (131), Expect = 1e-07
Identities = 56/233 (24%), Positives = 96/233 (41%), Gaps = 19/233 (8%)
Query: 171 GHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVW 230
GH V G L S S D V LWD+ + K L +
Sbjct: 61 GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVAR---------AKCLRVLKGHQRSVETV 111
Query: 231 SLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDI--LVTGTYDKKV 288
S + ++ SG WD V LWD+ + + ++ + P + L TG++D V
Sbjct: 112 SFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTV 171
Query: 289 TIYDPRAGPALLKHQQL--HSRPVLTLLADDRHII-SGSEDHTLVVVDRRANSVLQRLQL 345
I+D R + HQ L HS + L ++ SGS D T+ + +S+L +L+
Sbjct: 172 HIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKG 231
Query: 346 D-SYLLCMSYQEPQLW---AGDNQGLLHVFANRNGCFQLIRS-FDVGHSFPIT 393
+++ +++ +LW AG ++ + N C + ++ DV H+ T
Sbjct: 232 HVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFT 284
Score = 52.4 bits (124), Expect = 9e-07
Identities = 40/137 (29%), Positives = 65/137 (47%), Gaps = 15/137 (10%)
Query: 170 EGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWV 229
+GH SV++V SG D+ V LWD+ +S Q+L +G R+S
Sbjct: 102 KGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV-----QSGQMLRLLVG-HRDSIQSS-- 153
Query: 230 WSLAAQDHRVCSGSWDSTVKLWDM-----AADGQQFGEIKASSAVLCLSYLPDILVTGTY 284
+ + + +GSWDSTV +WD+ A Q A+ + LC S +L +G++
Sbjct: 154 -DFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYS-ASGLLASGSW 211
Query: 285 DKKVTIYDPRAGPALLK 301
DK + I+ P L++
Sbjct: 212 DKTIHIWKPTTSSLLIQ 228
Score = 45.8 bits (107), Expect = 8e-05
Identities = 74/298 (24%), Positives = 123/298 (41%), Gaps = 42/298 (14%)
Query: 172 HVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWV-- 229
H V+S G + L+GS D V W+ T S Q+L + G H G V
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWE-----TRSGQLLWRLGG------HTGPVKF 68
Query: 230 WSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKA-SSAVLCLSYLPDI--LVTGTYDK 286
+ H S S D TV+LWD+A + +K +V +S+ PD L +G +DK
Sbjct: 69 CRFSPDGHLFASASCDCTVRLWDVAR-AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDK 127
Query: 287 KVTIYDPRAGP---ALLKH----QQLHSRPVLTLLADDRHIISGSEDHTLVVVD-RRANS 338
+V ++D ++G L+ H Q P + LA +GS D T+ + D R
Sbjct: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLA------TGSWDSTVHIWDLRMVTP 181
Query: 339 VLQRLQLDSY---LLCMSYQEPQLWA-GDNQGLLHVFANRNGCFQLIRSFDVGHSFPITG 394
+ L+ + + C+ Y L A G +H++ + GH +
Sbjct: 182 AVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLK---GHVTWVKS 238
Query: 395 IQYSVGALYTTSTDKTIRVHV-PTDPPRTICTRRHDNGLNRVCA---EGNLVVAGSGD 448
I +S L+ S + V V + + + T + + CA +G ++V+G+ D
Sbjct: 239 IAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 54.7 bits (130), Expect = 2e-07
Identities = 55/210 (26%), Positives = 79/210 (37%), Gaps = 38/210 (18%)
Query: 171 GHVASVDSVLLLQGGSLCLSGSRDRNVNLW-------------------------DLRQL 205
GH +V V G L SGSRD+ V +W D +
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 80
Query: 206 GTESNQVLIKTLGTKRN------STHEGWV--WSLAAQDHRVCSGSWDSTVKLWDMAADG 257
T S+ +K T R S H WV + + S S D TVKLWD ++
Sbjct: 81 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 140
Query: 258 QQFGEIKASSAVLCLSYLPD--ILVTGTYDKKVTIYDPRAGPALLKHQQLHSRPV--LTL 313
+ V + + P + D V ++D R LL+H QLHS V L+
Sbjct: 141 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT-HRLLQHYQLHSAAVNGLSF 199
Query: 314 LADDRHIISGSEDHTLVVVDRRANSVLQRL 343
++I+ S D TL ++D +L L
Sbjct: 200 HPSGNYLITASSDSTLKILDLMEGRLLYTL 229
Score = 36.6 bits (83), Expect = 0.049
Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 4/72 (5%)
Query: 387 GHSFPITGIQYSVGA--LYTTSTDKTIRVHVPTDPPRTICTRRHDNGLNRV--CAEGNLV 442
GH +T + +S L + S DKT+R+ VP + R H + V C++G
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 80
Query: 443 VAGSGDLSLEVW 454
V S D +++VW
Sbjct: 81 VTASDDKTVKVW 92
Score = 32.7 bits (73), Expect = 0.70
Identities = 39/228 (17%), Positives = 88/228 (38%), Gaps = 31/228 (13%)
Query: 245 DSTVKLWDMAADGQQFGEIKASSAVLCLSYLPD--ILVTGTYDKKVTIYDPRA-GPALLK 301
DS + +W M + + AV C+++ P +L +G+ DK V I+ P G + +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 302 HQQLHSRPVLTLLADDRHIISGSEDHTLVV-VDRRANSVLQRLQLDSYLLCMSY------ 354
+ + +D + ++ S+D T+ V R + Q +++ C +
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 355 -------QEPQLWAGDNQGLLHVFANRNGCFQLIRSFDVGHSFPITGIQYSVGALYTTST 407
+ +LW ++ +H + G + G G+ +V ++ T
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV-KVWDVRT 180
Query: 408 DKTIRVHVPTDPPRTICTRRHDNGLNRVC--AEGNLVVAGSGDLSLEV 453
+ ++ + + H +N + GN ++ S D +L++
Sbjct: 181 HRLLQHY-----------QLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 54.7 bits (130), Expect = 2e-07
Identities = 55/210 (26%), Positives = 79/210 (37%), Gaps = 38/210 (18%)
Query: 171 GHVASVDSVLLLQGGSLCLSGSRDRNVNLW-------------------------DLRQL 205
GH +V V G L SGSRD+ V +W D +
Sbjct: 59 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 118
Query: 206 GTESNQVLIKTLGTKRN------STHEGWV--WSLAAQDHRVCSGSWDSTVKLWDMAADG 257
T S+ +K T R S H WV + + S S D TVKLWD ++
Sbjct: 119 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 178
Query: 258 QQFGEIKASSAVLCLSYLPD--ILVTGTYDKKVTIYDPRAGPALLKHQQLHSRPV--LTL 313
+ V + + P + D V ++D R LL+H QLHS V L+
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT-HRLLQHYQLHSAAVNGLSF 237
Query: 314 LADDRHIISGSEDHTLVVVDRRANSVLQRL 343
++I+ S D TL ++D +L L
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEGRLLYTL 267
Score = 38.5 bits (88), Expect = 0.013
Identities = 42/235 (17%), Positives = 93/235 (39%), Gaps = 31/235 (13%)
Query: 238 RVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPD--ILVTGTYDKKVTIYDPRA 295
++ SGS DS + +W M + + AV C+++ P +L +G+ DK V I+ P
Sbjct: 33 QLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNV 92
Query: 296 -GPALLKHQQLHSRPVLTLLADDRHIISGSEDHTLVV-VDRRANSVLQRLQLDSYLLCMS 353
G + + + + +D + ++ S+D T+ V R + Q +++ C
Sbjct: 93 KGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAK 152
Query: 354 Y-------------QEPQLWAGDNQGLLHVFANRNGCFQLIRSFDVGHSFPITGIQYSVG 400
+ + +LW ++ +H + G + G G+ +V
Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV- 211
Query: 401 ALYTTSTDKTIRVHVPTDPPRTICTRRHDNGLNRVC--AEGNLVVAGSGDLSLEV 453
++ T + ++ + + H +N + GN ++ S D +L++
Sbjct: 212 KVWDVRTHRLLQHY-----------QLHSAAVNGLSFHPSGNYLITASSDSTLKI 255
Score = 36.6 bits (83), Expect = 0.049
Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 4/72 (5%)
Query: 387 GHSFPITGIQYSVGA--LYTTSTDKTIRVHVPTDPPRTICTRRHDNGLNRV--CAEGNLV 442
GH +T + +S L + S DKT+R+ VP + R H + V C++G
Sbjct: 59 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 118
Query: 443 VAGSGDLSLEVW 454
V S D +++VW
Sbjct: 119 VTASDDKTVKVW 130
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 54.7 bits (130), Expect = 2e-07
Identities = 55/210 (26%), Positives = 79/210 (37%), Gaps = 38/210 (18%)
Query: 171 GHVASVDSVLLLQGGSLCLSGSRDRNVNLW-------------------------DLRQL 205
GH +V V G L SGSRD+ V +W D +
Sbjct: 59 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 118
Query: 206 GTESNQVLIKTLGTKRN------STHEGWV--WSLAAQDHRVCSGSWDSTVKLWDMAADG 257
T S+ +K T R S H WV + + S S D TVKLWD ++
Sbjct: 119 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 178
Query: 258 QQFGEIKASSAVLCLSYLPD--ILVTGTYDKKVTIYDPRAGPALLKHQQLHSRPV--LTL 313
+ V + + P + D V ++D R LL+H QLHS V L+
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT-HRLLQHYQLHSAAVNGLSF 237
Query: 314 LADDRHIISGSEDHTLVVVDRRANSVLQRL 343
++I+ S D TL ++D +L L
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEGRLLYTL 267
Score = 38.5 bits (88), Expect = 0.013
Identities = 42/235 (17%), Positives = 93/235 (39%), Gaps = 31/235 (13%)
Query: 238 RVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPD--ILVTGTYDKKVTIYDPRA 295
++ SGS DS + +W M + + AV C+++ P +L +G+ DK V I+ P
Sbjct: 33 QLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNV 92
Query: 296 -GPALLKHQQLHSRPVLTLLADDRHIISGSEDHTLVV-VDRRANSVLQRLQLDSYLLCMS 353
G + + + + +D + ++ S+D T+ V R + Q +++ C
Sbjct: 93 KGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAK 152
Query: 354 Y-------------QEPQLWAGDNQGLLHVFANRNGCFQLIRSFDVGHSFPITGIQYSVG 400
+ + +LW ++ +H + G + G G+ +V
Sbjct: 153 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV- 211
Query: 401 ALYTTSTDKTIRVHVPTDPPRTICTRRHDNGLNRVC--AEGNLVVAGSGDLSLEV 453
++ T + ++ + + H +N + GN ++ S D +L++
Sbjct: 212 KVWDVRTHRLLQHY-----------QLHSAAVNGLSFHPSGNYLITASSDSTLKI 255
Score = 36.6 bits (83), Expect = 0.049
Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 4/72 (5%)
Query: 387 GHSFPITGIQYSVGA--LYTTSTDKTIRVHVPTDPPRTICTRRHDNGLNRV--CAEGNLV 442
GH +T + +S L + S DKT+R+ VP + R H + V C++G
Sbjct: 59 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 118
Query: 443 VAGSGDLSLEVW 454
V S D +++VW
Sbjct: 119 VTASDDKTVKVW 130
>gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog
[Homo sapiens]
Length = 518
Score = 53.9 bits (128), Expect = 3e-07
Identities = 55/215 (25%), Positives = 94/215 (43%), Gaps = 21/215 (9%)
Query: 183 QGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVWSLAAQDHRVCSG 242
Q G L ++GS D V L+D+ S + ++ + H A + V SG
Sbjct: 90 QDGRLLVAGSEDGGVQLFDI------SGRAPLRQFEGHTKAVH---TVDFTADKYHVVSG 140
Query: 243 SWDSTVKLWDMAADGQ--QFGEIKASSAVLCLSYL-PDILVTGTYDKKVTIYDPRAGPAL 299
+ D TVKLWD+ + F E C S L PD+ +TG+YD V ++D R ++
Sbjct: 141 ADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESV 200
Query: 300 LKHQQLHSRPV--LTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQ---LDSYLLCMSY 354
L + H +PV + L ++S + V + +L L+ LC+S
Sbjct: 201 LSVE--HGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSS 258
Query: 355 QEPQLWAGDNQGLLHVFANRNGCFQLIRSFDVGHS 389
+L +G + V++ + ++++ SFD S
Sbjct: 259 SGQRLLSGSLDRKVKVYSTTS--YKVVHSFDYAAS 291
Score = 42.0 bits (97), Expect = 0.001
Identities = 45/205 (21%), Positives = 82/205 (40%), Gaps = 12/205 (5%)
Query: 170 EGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWV 229
EGH +V +V +SG+ D V LWD+ S ++L K +S +
Sbjct: 119 EGHTKAVHTVDFTADKYHVVSGADDYTVKLWDI----PNSKEILT----FKEHSDYVRCG 170
Query: 230 WSLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPDILVTGTYDKKVT 289
+ +GS+D TVK++D L + L+ + V
Sbjct: 171 CASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVK 230
Query: 290 IYDPRAGPALLKHQQLHSRPV--LTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQLDS 347
++D G LL + H + V L L + + ++SGS D + V + V+ +
Sbjct: 231 VWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAA 290
Query: 348 YL--LCMSYQEPQLWAGDNQGLLHV 370
+ L +++++ + G G+L V
Sbjct: 291 SILSLALAHEDETIVVGMTNGILSV 315
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 53.5 bits (127), Expect = 4e-07
Identities = 49/167 (29%), Positives = 74/167 (44%), Gaps = 25/167 (14%)
Query: 172 HVASVDSVLLLQGGSLCL-SGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVW 230
H V + GSL L S SRD+ + +WDL+ G ++K L H+ WV+
Sbjct: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGN-----MMKVL-----RGHQNWVY 218
Query: 231 SLA--AQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSA----VLCLSYLPD--ILVTG 282
S A +CS V LW+M ++ I+ V+ + PD +L T
Sbjct: 219 SCAFSPDSSMLCSVGASKAVFLWNM----DKYTMIRKLEGHHHDVVACDFSPDGALLATA 274
Query: 283 TYDKKVTIYDPRAGPALLKHQQLH--SRPVLTLLADDRHIISGSEDH 327
+YD +V I+DP G L++ L P+ A+DR + S S H
Sbjct: 275 SYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 321
Score = 30.0 bits (66), Expect = 4.6
Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 9/137 (6%)
Query: 170 EGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLR--QLGTESNQVLIKTLGTKRNSTHEG 227
EGH V + G+L + S D V +WD + E + ++
Sbjct: 253 EGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDR 312
Query: 228 WVWSLAAQDH--RVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPD--ILVTGT 283
WV S++ V S + D V+ W + D ++ S LC ++ D +L GT
Sbjct: 313 WVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV--QVAPLSNGLCCAFSTDGSVLAAGT 370
Query: 284 YDKKVTIY-DPRAGPAL 299
+D V + PR P+L
Sbjct: 371 HDGSVYFWATPRQVPSL 387
>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
sapiens]
Length = 275
Score = 53.5 bits (127), Expect = 4e-07
Identities = 49/167 (29%), Positives = 74/167 (44%), Gaps = 25/167 (14%)
Query: 172 HVASVDSVLLLQGGSLCL-SGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVW 230
H V + GSL L S SRD+ + +WDL+ G ++K L H+ WV+
Sbjct: 23 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGN-----MMKVL-----RGHQNWVY 72
Query: 231 SLA--AQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSA----VLCLSYLPD--ILVTG 282
S A +CS V LW+M ++ I+ V+ + PD +L T
Sbjct: 73 SCAFSPDSSMLCSVGASKAVFLWNM----DKYTMIRKLEGHHHDVVACDFSPDGALLATA 128
Query: 283 TYDKKVTIYDPRAGPALLKHQQLH--SRPVLTLLADDRHIISGSEDH 327
+YD +V I+DP G L++ L P+ A+DR + S S H
Sbjct: 129 SYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 175
Score = 30.0 bits (66), Expect = 4.6
Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 9/137 (6%)
Query: 170 EGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLR--QLGTESNQVLIKTLGTKRNSTHEG 227
EGH V + G+L + S D V +WD + E + ++
Sbjct: 107 EGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDR 166
Query: 228 WVWSLAAQDH--RVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPD--ILVTGT 283
WV S++ V S + D V+ W + D ++ S LC ++ D +L GT
Sbjct: 167 WVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV--QVAPLSNGLCCAFSTDGSVLAAGT 224
Query: 284 YDKKVTIY-DPRAGPAL 299
+D V + PR P+L
Sbjct: 225 HDGSVYFWATPRQVPSL 241
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 52.4 bits (124), Expect = 9e-07
Identities = 80/338 (23%), Positives = 137/338 (40%), Gaps = 52/338 (15%)
Query: 170 EGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDL-------------------------RQ 204
EGH +V SV G SGS D V WDL R+
Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170
Query: 205 L--GTESNQVLIKTLGTKRN-----STHEGWVWSLAAQD-------HRVCSGSWDSTVKL 250
L G ++ Q+L+ T + + H W+ L+ + V S S D +V++
Sbjct: 171 LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRI 230
Query: 251 WDMAADGQQFGEIKASSAVLCLSYLPD-ILVTGTYDKKVTIYDPRAGPALLKHQQLHSRP 309
WD A + + +V CL + D +L + + D+ + ++ G L + Q H
Sbjct: 231 WDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDG-VLCRTLQGHGHW 289
Query: 310 VLTL-LADDRHIISGS-EDHTLVVVDRRANSVLQRLQ---LDSYLLCMSYQEPQLWAGDN 364
V T+ L+ D + +G+ E V + LQ L+ L Y L +L +G +
Sbjct: 290 VNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSD 349
Query: 365 QGLLHVFANRNGCFQLIRSFDVGHSFPITGIQYSVGA--LYTTSTDKTIRVHVPTDPPRT 422
L +++ L R GH I + +S + + + S DK+I++
Sbjct: 350 DFTLFLWSPAEDKKPLTRM--TGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYL 407
Query: 423 ICTRRHDNGLNRVC--AEGNLVVAGSGDLSLEVWRLQA 458
R H + ++ A+ L+V+GS D +L+VW ++A
Sbjct: 408 ASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKA 445
Score = 48.5 bits (114), Expect = 1e-05
Identities = 58/214 (27%), Positives = 88/214 (41%), Gaps = 44/214 (20%)
Query: 171 GHVASVDSVLLLQGGSLCLSGSRDRNVNLW---------DLRQLGTESNQVLIKTLGTKR 221
GH SV + L G L S S+DR + +W L+ G N + + T R
Sbjct: 244 GHTQSV-TCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALR 302
Query: 222 NSTHEGWVWSLAAQD------------------------HRVCSGSWDSTVKLWDMAADG 257
E S+ QD R+ SGS D T+ LW A D
Sbjct: 303 TGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDK 362
Query: 258 QQFGEIKASSAVLC-LSYLPD--ILVTGTYDKKVTIYDPRAGPALLKHQQLHSRPVLTLL 314
+ + A++ + + PD I+ + ++DK + ++D R G L + H V +
Sbjct: 363 KPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRG-HVAAVYQIA 421
Query: 315 --ADDRHIISGSEDHTLVVVDRRANSVLQRLQLD 346
AD R ++SGS D TL V D +A Q+L +D
Sbjct: 422 WSADSRLLVSGSSDSTLKVWDVKA----QKLAMD 451
Score = 41.2 bits (95), Expect = 0.002
Identities = 33/123 (26%), Positives = 54/123 (43%), Gaps = 11/123 (8%)
Query: 171 GHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESNQVLIKTLGTKRNSTHEGWVW 230
GH A ++ VL + S S D+++ LWD R K L + R +
Sbjct: 370 GHQALINQVLFSPDSRIVASASFDKSIKLWDGR---------TGKYLASLRGHVAAVYQI 420
Query: 231 SLAAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSYLPD--ILVTGTYDKKV 288
+ +A + SGS DST+K+WD+ A + V + + PD + +G DK +
Sbjct: 421 AWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCL 480
Query: 289 TIY 291
I+
Sbjct: 481 RIW 483
Score = 39.7 bits (91), Expect = 0.006
Identities = 30/107 (28%), Positives = 47/107 (43%), Gaps = 11/107 (10%)
Query: 145 ACIALEQHLSRWAEDGRWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQ 204
A + ++ + W DGR +Y GHVA+V + L +SGS D + +WD++
Sbjct: 388 ASASFDKSIKLW--DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKA 445
Query: 205 LGTESNQVLIKTLGTKRNSTHEGWVWSLAAQDHRVCSGSWDSTVKLW 251
Q L L + + WS Q RV SG D +++W
Sbjct: 446 ------QKLAMDLPGHADEVY-AVDWSPDGQ--RVASGGKDKCLRIW 483
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,232,314
Number of Sequences: 37866
Number of extensions: 876720
Number of successful extensions: 4797
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 169
Number of HSP's that attempted gapping in prelim test: 3698
Number of HSP's gapped (non-prelim): 792
length of query: 458
length of database: 18,247,518
effective HSP length: 106
effective length of query: 352
effective length of database: 14,233,722
effective search space: 5010270144
effective search space used: 5010270144
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.