Search of human proteins with 38424085

Search of human proteins with 38424085

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38424085 short-chain dehydrogenase/reductase 10 isoform b
[Homo sapiens]
         (286 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho...   565   e-161
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho...   438   e-123
gi|38424079 short-chain dehydrogenase/reductase 10 isoform c [Ho...   391   e-109
gi|38424075 short-chain dehydrogenase/reductase 10 isoform a [Ho...   358   4e-99
gi|38424083 short-chain dehydrogenase/reductase 10 isoform d [Ho...   298   5e-81
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]     220   1e-57
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      220   1e-57
gi|38424081 short-chain dehydrogenase/reductase 10 isoform f [Ho...   171   5e-43
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    90   2e-18
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    75   7e-14
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]         75   9e-14
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    72   6e-13
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom...    72   6e-13
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...    70   2e-12
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...    70   2e-12
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    65   9e-11
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          64   1e-10
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...    63   3e-10
gi|22507405 short chain dehydrogenase/reductase family 9C, membe...    62   4e-10
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]           59   5e-09
gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Hom...    59   6e-09
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]    58   1e-08
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...    57   2e-08
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    57   2e-08
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    57   2e-08
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    57   2e-08
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]            56   3e-08
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                   56   3e-08
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]     56   4e-08
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo...    54   1e-07

>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
           sapiens]
          Length = 286

 Score =  565 bits (1455), Expect = e-161
 Identities = 286/286 (100%), Positives = 286/286 (100%)

Query: 1   MKVLLLTGLGALFFAYYWDDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTA 60
           MKVLLLTGLGALFFAYYWDDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTA
Sbjct: 1   MKVLLLTGLGALFFAYYWDDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTA 60

Query: 61  HTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAP 120
           HTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAP
Sbjct: 61  HTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAP 120

Query: 121 AGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSA 180
           AGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSA
Sbjct: 121 AGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSA 180

Query: 181 AKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAALAV 240
           AKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAALAV
Sbjct: 181 AKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAALAV 240

Query: 241 IRGGATRAAGVFYPWRFRLLCLLRRWLPRPRAWFIRQELNVTAAAA 286
           IRGGATRAAGVFYPWRFRLLCLLRRWLPRPRAWFIRQELNVTAAAA
Sbjct: 241 IRGGATRAAGVFYPWRFRLLCLLRRWLPRPRAWFIRQELNVTAAAA 286


>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
           sapiens]
          Length = 315

 Score =  438 bits (1127), Expect = e-123
 Identities = 224/226 (99%), Positives = 224/226 (99%)

Query: 1   MKVLLLTGLGALFFAYYWDDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTA 60
           MKVLLLTGLGALFFAYYWDDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTA
Sbjct: 1   MKVLLLTGLGALFFAYYWDDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTA 60

Query: 61  HTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAP 120
           HTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAP
Sbjct: 61  HTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAP 120

Query: 121 AGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSA 180
           AGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSA
Sbjct: 121 AGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSA 180

Query: 181 AKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRGVT 226
           AKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVR  T
Sbjct: 181 AKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRSST 226


>gi|38424079 short-chain dehydrogenase/reductase 10 isoform c [Homo
           sapiens]
          Length = 199

 Score =  391 bits (1005), Expect = e-109
 Identities = 199/199 (100%), Positives = 199/199 (100%)

Query: 88  MASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTS 147
           MASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTS
Sbjct: 1   MASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTS 60

Query: 148 RALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITM 207
           RALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITM
Sbjct: 61  RALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITM 120

Query: 208 CVLGLRDRASAAEAVRGVTRVKAAPGPKAALAVIRGGATRAAGVFYPWRFRLLCLLRRWL 267
           CVLGLRDRASAAEAVRGVTRVKAAPGPKAALAVIRGGATRAAGVFYPWRFRLLCLLRRWL
Sbjct: 121 CVLGLRDRASAAEAVRGVTRVKAAPGPKAALAVIRGGATRAAGVFYPWRFRLLCLLRRWL 180

Query: 268 PRPRAWFIRQELNVTAAAA 286
           PRPRAWFIRQELNVTAAAA
Sbjct: 181 PRPRAWFIRQELNVTAAAA 199


>gi|38424075 short-chain dehydrogenase/reductase 10 isoform a [Homo
           sapiens]
          Length = 205

 Score =  358 bits (918), Expect = 4e-99
 Identities = 181/181 (100%), Positives = 181/181 (100%)

Query: 106 GGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSS 165
           GGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSS
Sbjct: 25  GGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSS 84

Query: 166 LLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRGV 225
           LLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRGV
Sbjct: 85  LLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRGV 144

Query: 226 TRVKAAPGPKAALAVIRGGATRAAGVFYPWRFRLLCLLRRWLPRPRAWFIRQELNVTAAA 285
           TRVKAAPGPKAALAVIRGGATRAAGVFYPWRFRLLCLLRRWLPRPRAWFIRQELNVTAAA
Sbjct: 145 TRVKAAPGPKAALAVIRGGATRAAGVFYPWRFRLLCLLRRWLPRPRAWFIRQELNVTAAA 204

Query: 286 A 286
           A
Sbjct: 205 A 205



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 25/27 (92%), Positives = 25/27 (92%)

Query: 1  MKVLLLTGLGALFFAYYWDDNFDPASL 27
          MKVLLLTGLGALFFAYYWDDNFDP  L
Sbjct: 1  MKVLLLTGLGALFFAYYWDDNFDPGGL 27


>gi|38424083 short-chain dehydrogenase/reductase 10 isoform d [Homo
           sapiens]
          Length = 152

 Score =  298 bits (762), Expect = 5e-81
 Identities = 152/152 (100%), Positives = 152/152 (100%)

Query: 135 MQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRR 194
           MQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRR
Sbjct: 1   MQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRR 60

Query: 195 ELDVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAALAVIRGGATRAAGVFYP 254
           ELDVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAALAVIRGGATRAAGVFYP
Sbjct: 61  ELDVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAALAVIRGGATRAAGVFYP 120

Query: 255 WRFRLLCLLRRWLPRPRAWFIRQELNVTAAAA 286
           WRFRLLCLLRRWLPRPRAWFIRQELNVTAAAA
Sbjct: 121 WRFRLLCLLRRWLPRPRAWFIRQELNVTAAAA 152


>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score =  220 bits (561), Expect = 1e-57
 Identities = 124/256 (48%), Positives = 162/256 (63%), Gaps = 4/256 (1%)

Query: 1   MKVLLLTGLGALFFAYYW---DDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLV 57
           MK  LL  LG LF AYY+   ++ F P  LQG +V++TGA+ G+G E+AYH A++G+H+V
Sbjct: 4   MKKYLLPILG-LFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVV 62

Query: 58  LTAHTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIG 117
           +TA ++  LQKVV +C +LGA    YIA  M      E  V  A   +GGLD L+LNHI 
Sbjct: 63  VTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHIT 122

Query: 118 GAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTP 177
                         R  M+VNF+SYV LT  ALP L  S GS+VVVSSL G+V       
Sbjct: 123 NTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAA 182

Query: 178 YSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAA 237
           YSA+KFALDGFF S+R+E  V  VNV+IT+CVLGL D  +A +AV G+  ++AAP  + A
Sbjct: 183 YSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA 242

Query: 238 LAVIRGGATRAAGVFY 253
           L +I+GGA R   V+Y
Sbjct: 243 LEIIKGGALRQEEVYY 258


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score =  220 bits (561), Expect = 1e-57
 Identities = 124/256 (48%), Positives = 162/256 (63%), Gaps = 4/256 (1%)

Query: 1   MKVLLLTGLGALFFAYYW---DDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLV 57
           MK  LL  LG LF AYY+   ++ F P  LQG +V++TGA+ G+G E+AYH A++G+H+V
Sbjct: 4   MKKYLLPILG-LFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVV 62

Query: 58  LTAHTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIG 117
           +TA ++  LQKVV +C +LGA    YIA  M      E  V  A   +GGLD L+LNHI 
Sbjct: 63  VTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHIT 122

Query: 118 GAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTP 177
                         R  M+VNF+SYV LT  ALP L  S GS+VVVSSL G+V       
Sbjct: 123 NTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAA 182

Query: 178 YSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAA 237
           YSA+KFALDGFF S+R+E  V  VNV+IT+CVLGL D  +A +AV G+  ++AAP  + A
Sbjct: 183 YSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECA 242

Query: 238 LAVIRGGATRAAGVFY 253
           L +I+GGA R   V+Y
Sbjct: 243 LEIIKGGALRQEEVYY 258


>gi|38424081 short-chain dehydrogenase/reductase 10 isoform f [Homo
           sapiens]
          Length = 181

 Score =  171 bits (434), Expect = 5e-43
 Identities = 90/92 (97%), Positives = 90/92 (97%)

Query: 135 MQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRR 194
           MQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRR
Sbjct: 1   MQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRR 60

Query: 195 ELDVQDVNVAITMCVLGLRDRASAAEAVRGVT 226
           ELDVQDVNVAITMCVLGLRDRASAAEAVR  T
Sbjct: 61  ELDVQDVNVAITMCVLGLRDRASAAEAVRSST 92


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 60/181 (33%), Positives = 93/181 (51%), Gaps = 4/181 (2%)

Query: 32  VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPK---VFYIAADM 88
           V +TGA++G+GEELAY  ++LG  LVL+A     L++V   C + G  K   +  +  D+
Sbjct: 53  VWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDL 112

Query: 89  ASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSR 148
               + E+  +  L + G +D LV N      +     S    R L+++N++  V LT  
Sbjct: 113 TDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKC 172

Query: 149 ALPSLTDSK-GSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITM 207
            LP + + K G +V V+S+LG +    S  Y A+K AL GFF  LR EL      +   +
Sbjct: 173 VLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNI 232

Query: 208 C 208
           C
Sbjct: 233 C 233


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 53/188 (28%), Positives = 94/188 (50%), Gaps = 8/188 (4%)

Query: 25  ASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVV-----GNCRKLGAP 79
           A L+ A V++TGA +G+G+E A  +   G+ LVL       L++++      +  K+   
Sbjct: 48  AYLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTH 107

Query: 80  KVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGT-RARSPQATRWLMQVN 138
           K + +  D+    A  +     L   G +D LV N+ G +  GT    +    + +M+ N
Sbjct: 108 KPYLVTFDLTDSGAIVAAAAEILQCFGYVDILV-NNAGISYRGTIMDTTVDVDKRVMETN 166

Query: 139 FVSYVQLTSRALPSLTDSK-GSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELD 197
           +   V LT   LPS+   + G +V +SS+ G++   F + Y+A+K A   FF  LR E++
Sbjct: 167 YFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEME 226

Query: 198 VQDVNVAI 205
             ++ V +
Sbjct: 227 QYEIEVTV 234


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 74.7 bits (182), Expect = 9e-14
 Identities = 69/258 (26%), Positives = 113/258 (43%), Gaps = 5/258 (1%)

Query: 26  SLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIA 85
           S+ G  VL+TGA  G+G   AY +A+L S LVL    +  L++    C+ LGA KV    
Sbjct: 33  SVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGA-KVHTFV 91

Query: 86  ADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQL 145
            D ++ E   S  +    ++G +  LV N      +   A          +VN +++   
Sbjct: 92  VDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWT 151

Query: 146 TSRALPSLT-DSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVA 204
           T   LP++T ++ G +V V+S  G V   F   Y ++KFA  GF  +L  EL    +   
Sbjct: 152 TKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGV 211

Query: 205 ITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAAL-AVIRGGATRAAGVFYPWRFRLLCLL 263
            T C+    +  +        T +     P+  +  ++ G  T    +F P     L  L
Sbjct: 212 KTTCL--CPNFVNTGFIKNPSTSLGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTTL 269

Query: 264 RRWLPRPRAWFIRQELNV 281
            R LP      ++Q+++V
Sbjct: 270 ERILPERFLAVLKQKISV 287


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 65/259 (25%), Positives = 112/259 (43%), Gaps = 7/259 (2%)

Query: 26  SLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIA 85
           S+ G  VL+TGA  G+G +  Y +A+  S LVL    +  +++    CRKLG     Y+ 
Sbjct: 33  SVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVV 92

Query: 86  ADMASPEAPESVVQFALDKLGGLDYLVLNHIGGA-PAGTRARSPQATRWLMQVNFVSYVQ 144
                 E   S+ Q  + K  G   +V+N+ G   PA   +   +      +VN + +  
Sbjct: 93  DCSNREEIYRSLNQ--VKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFW 150

Query: 145 LTSRALPSLTD-SKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNV 203
           +T   LPS+ + + G +V V+S+ G     +  PY ++KFA  GF   L  EL       
Sbjct: 151 ITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTG 210

Query: 204 AITMCVLGLRDRASAAEAVRGVTRV-KAAPGPKAALAVIRGGATRAAGVFYPWRFRLLCL 262
             T C+  +    +        TR+       +   ++I G  T    +F P    +   
Sbjct: 211 IKTSCLCPV--FVNTGFTKNPSTRLWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLR 268

Query: 263 LRRWLPRPRAWFIRQELNV 281
           L+++LP   +  + +  N+
Sbjct: 269 LQKFLPERASAILNRMQNI 287


>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
           sapiens]
          Length = 311

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 58/212 (27%), Positives = 100/212 (47%), Gaps = 10/212 (4%)

Query: 1   MKVLLLTGLGALFFAYYWDDN-FDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLT 59
           M  LLL G+  L F Y      +  +++Q   V++T A +G+G+E A  +   G+ LVL 
Sbjct: 8   MLPLLLLGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTGGARLVLC 67

Query: 60  AHTEALLQKV------VGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVL 113
                 L+ +      V +  K   PK+  +  D++       V +  LD  G +D L+ 
Sbjct: 68  GKNWERLENLYDALISVADPSKTFTPKL--VLLDLSDISCVPDVAKEVLDCYGCVDILIN 125

Query: 114 NHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSK-GSLVVVSSLLGRVPT 172
           N            S +  + +M  N+   + LT   LP++   + G +V+V+++ G+   
Sbjct: 126 NASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFGI 185

Query: 173 SFSTPYSAAKFALDGFFGSLRRELDVQDVNVA 204
            F T Y+A+K A  GFF  LR E++  DV ++
Sbjct: 186 PFRTTYAASKHAALGFFDCLRAEVEEYDVVIS 217


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 51/175 (29%), Positives = 91/175 (52%), Gaps = 8/175 (4%)

Query: 33  LLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASPE 92
           ++TG+ +G+G  +A   AR G+H+V+++  +  + + +   +  G   V  I   +   E
Sbjct: 40  VVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGL-SVAGIVCHVGKAE 98

Query: 93  APESVVQFALDKLGGLDYLV----LNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSR 148
             E +V  AL+  GG+D+LV    +N + G+  GT   S Q    ++ VN  S   L S+
Sbjct: 99  DREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGT---SEQIWDKILSVNVKSPALLLSQ 155

Query: 149 ALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNV 203
            LP + + +G++++VSS+    P      Y+ +K AL G   +L  EL  +D+ V
Sbjct: 156 LLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRV 210


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 51/175 (29%), Positives = 91/175 (52%), Gaps = 8/175 (4%)

Query: 33  LLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASPE 92
           ++TG+ +G+G  +A   AR G+H+V+++  +  + + +   +  G   V  I   +   E
Sbjct: 40  VVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGL-SVAGIVCHVGKAE 98

Query: 93  APESVVQFALDKLGGLDYLV----LNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSR 148
             E +V  AL+  GG+D+LV    +N + G+  GT   S Q    ++ VN  S   L S+
Sbjct: 99  DREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGT---SEQIWDKILSVNVKSPALLLSQ 155

Query: 149 ALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNV 203
            LP + + +G++++VSS+    P      Y+ +K AL G   +L  EL  +D+ V
Sbjct: 156 LLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRV 210


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 61/206 (29%), Positives = 104/206 (50%), Gaps = 9/206 (4%)

Query: 24  PASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALL---QKVVGNCRKLGAPK 80
           P +L GA V++TG ++G+G+ +A    + G+ + L A  E  L   +K +          
Sbjct: 27  PLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQV 86

Query: 81  VFYIAADMASP-EAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQAT-RWLMQVN 138
           V  I+ D++      E+V++ A +KLG +D LV N  G A +G       +T   LM +N
Sbjct: 87  VLCISVDVSQDYNQVENVIKQAQEKLGPVDMLV-NCAGMAVSGKFEDLEVSTFERLMSIN 145

Query: 139 FVSYVQLTSRALPSLTDSK-GSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELD 197
           ++  V  +   + ++ + + G +V VSS  G++     T YSA+KFA+ G   +L  +++
Sbjct: 146 YLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEAL--QME 203

Query: 198 VQDVNVAITMCVLGLRDRASAAEAVR 223
           V+  NV IT+      D    AE  R
Sbjct: 204 VKPYNVYITVAYPPDTDTPGFAEENR 229


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 56/176 (31%), Positives = 80/176 (45%), Gaps = 21/176 (11%)

Query: 32  VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASP 91
           VL++G ++G+G ELA          V  AH      +VV   R LG  +    AA  A  
Sbjct: 8   VLISGCSSGIGLELA----------VQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALG 57

Query: 92  E----------APESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVS 141
           +          + ESV Q      G +D LV N   G        S  A + +   NF  
Sbjct: 58  QTLTVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFG 117

Query: 142 YVQLTSRALPSLTDSK-GSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRREL 196
            V+L    LP +   + G +VV+SS++G     F+  Y+A+KFAL+GFF SL  +L
Sbjct: 118 AVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQL 173


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 44/159 (27%), Positives = 78/159 (49%), Gaps = 8/159 (5%)

Query: 29  GARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADM 88
           G  V++TG   G+G  +   +   G+ +V+    E+      G   +   P   +I  D+
Sbjct: 9   GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDES-----GGRALEQELPGAVFILCDV 63

Query: 89  ASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRAR--SPQATRWLMQVNFVSYVQLT 146
              +  +++V   + + G LD  V+N+ G  P   R    S Q  R L+++N +    LT
Sbjct: 64  TQEDDVKTLVSETIRRFGRLD-CVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLT 122

Query: 147 SRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFAL 185
             ALP L  S+G+++ +SSL+G +  + + PY A K A+
Sbjct: 123 KLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAV 161


>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
           [Homo sapiens]
          Length = 313

 Score = 62.4 bits (150), Expect = 4e-10
 Identities = 60/211 (28%), Positives = 94/211 (44%), Gaps = 23/211 (10%)

Query: 6   LTGLGALFFAYYWDDNFD-PASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEA 64
           +  L  L F Y W  N +   +L    V +TG ++G G  LA      G  ++    TE 
Sbjct: 1   MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE 60

Query: 65  LLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLG--GLDYLVLNHIGGAPAG 122
             QK+    ++  + ++     D+   E+ ++  Q+  DK+G  GL  LV N   G P+G
Sbjct: 61  GSQKL----QRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG 116

Query: 123 TRARSPQATRWL--------MQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSF 174
                     WL        + VN V  +++T   LP +  ++G +V +SS  GRV    
Sbjct: 117 PN-------EWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAV-I 168

Query: 175 STPYSAAKFALDGFFGSLRRELDVQDVNVAI 205
              Y  +KF ++ F  S+RREL    V V I
Sbjct: 169 GGGYCVSKFGVEAFSDSIRRELYYFGVKVCI 199


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score = 58.9 bits (141), Expect = 5e-09
 Identities = 52/177 (29%), Positives = 80/177 (45%), Gaps = 5/177 (2%)

Query: 26  SLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIA 85
           ++ G  VL+TGA +G+G  LA  +ARLGS LVL    +   ++     R+ GA +V    
Sbjct: 37  NVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYT 96

Query: 86  ADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARS--PQATRWLMQVNFVSYV 143
            D +  E    V      ++G +  L+ N   G   G +      +       VNF +++
Sbjct: 97  CDCSQKEGVYRVADQVKKEVGDVSILINN--AGIVTGKKFLDCPDELMEKSFDVNFKAHL 154

Query: 144 QLTSRALPS-LTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQ 199
                 LP+ + +  G LV +SS  G    +    Y A+KFA  GF  S+  E  VQ
Sbjct: 155 WTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQ 211


>gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Homo
           sapiens]
          Length = 377

 Score = 58.5 bits (140), Expect = 6e-09
 Identities = 69/242 (28%), Positives = 104/242 (42%), Gaps = 21/242 (8%)

Query: 1   MKVLLLTG---LGALFFAYYWDDNFDPA----SLQGARVLLTGANAGVGEELAYHYARLG 53
           M+ LLL     LGA    YY      P     +L+G   ++TGAN+G+G+  A   AR G
Sbjct: 1   MEALLLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRG 60

Query: 54  SHLVLTAHTEALLQKVVGNCR-KLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLV 112
           + +VL   ++   +    + R + G  +V ++A D+AS  +  +     L     LD L+
Sbjct: 61  ARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILI 120

Query: 113 LNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPT 172
            N    A   +  R+ +A   L++VN +    LT   LP L     S VVV +       
Sbjct: 121 HN----AGISSCGRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRG 176

Query: 173 SFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAP 232
                +      + G+   LR   D +  N      VL  R+ A+  EA  GVT   A P
Sbjct: 177 RLD--FKRLDRPVVGWRQELRAYADTKLAN------VLFARELANQLEAT-GVTCYAAHP 227

Query: 233 GP 234
           GP
Sbjct: 228 GP 229


>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
          Length = 317

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 54/207 (26%), Positives = 97/207 (46%), Gaps = 11/207 (5%)

Query: 4   LLLTGLGALFFAYYWDDNFDPAS-LQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHT 62
           L L     L++  +W       S LQ   V +TG ++G G  LA      G  ++    T
Sbjct: 3   LYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLT 62

Query: 63  EALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLG--GLDYLVLNHIGGAP 120
           E   +++ G      + ++  +  D+   E+  +  Q+  + +G  GL  LV N+ G   
Sbjct: 63  EKGAEQLRGQT----SDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLV-NNAGILT 117

Query: 121 AGTRAR--SPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPY 178
             T     + + +  +++VN +  +Q+T   LP +  ++G +V VSS+LGRV   F   Y
Sbjct: 118 PITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRV-AFFVGGY 176

Query: 179 SAAKFALDGFFGSLRRELDVQDVNVAI 205
             +K+ ++ F   LRRE+    V ++I
Sbjct: 177 CVSKYGVEAFSDILRREIQHFGVKISI 203


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 55/206 (26%), Positives = 99/206 (48%), Gaps = 19/206 (9%)

Query: 9   LGALFFAYYW---DDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEAL 65
           LGAL +A  W   D    PAS   A V +TG ++G G  LA    + G  ++ +  T + 
Sbjct: 7   LGALLWAVLWLLRDRQSLPAS--NAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSG 64

Query: 66  LQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALD--KLGGLDYLVLNHIGGAPAGT 123
            + +    +++ + ++     D+  P++ +   ++     K  GL  LV N      AG 
Sbjct: 65  AEDL----QRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNN---AGVAGI 117

Query: 124 RARSPQATR----WLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYS 179
              +P  TR     ++ VN +  + +T   LP L  ++G ++ ++S+LGR+  +    Y 
Sbjct: 118 IGPTPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAAN-GGGYC 176

Query: 180 AAKFALDGFFGSLRRELDVQDVNVAI 205
            +KF L+ F  SLRR++    + V+I
Sbjct: 177 VSKFGLEAFSDSLRRDVAHFGIRVSI 202


>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 46/178 (25%), Positives = 82/178 (46%), Gaps = 4/178 (2%)

Query: 32  VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASP 91
           VL+TG ++G G  LA H    G  +      +      V     L + ++  +  ++ S 
Sbjct: 58  VLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSS 117

Query: 92  EAPESVVQFALDKLGGLD---YLVLNHIGGAPAG-TRARSPQATRWLMQVNFVSYVQLTS 147
           E  E VV+     L   +   + ++N+ G +  G     S +  + + +VN    V++T 
Sbjct: 118 EEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTK 177

Query: 148 RALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAI 205
             LP +  +KG +V +SS+LGR+     +PY   KF ++ F   LR E+    V V++
Sbjct: 178 SFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSV 235


>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 46/178 (25%), Positives = 82/178 (46%), Gaps = 4/178 (2%)

Query: 32  VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASP 91
           VL+TG ++G G  LA H    G  +      +      V     L + ++  +  ++ S 
Sbjct: 58  VLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSS 117

Query: 92  EAPESVVQFALDKLGGLD---YLVLNHIGGAPAG-TRARSPQATRWLMQVNFVSYVQLTS 147
           E  E VV+     L   +   + ++N+ G +  G     S +  + + +VN    V++T 
Sbjct: 118 EEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTK 177

Query: 148 RALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAI 205
             LP +  +KG +V +SS+LGR+     +PY   KF ++ F   LR E+    V V++
Sbjct: 178 SFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSV 235


>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 46/178 (25%), Positives = 82/178 (46%), Gaps = 4/178 (2%)

Query: 32  VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASP 91
           VL+TG ++G G  LA H    G  +      +      V     L + ++  +  ++ S 
Sbjct: 58  VLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSS 117

Query: 92  EAPESVVQFALDKLGGLD---YLVLNHIGGAPAG-TRARSPQATRWLMQVNFVSYVQLTS 147
           E  E VV+     L   +   + ++N+ G +  G     S +  + + +VN    V++T 
Sbjct: 118 EEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTK 177

Query: 148 RALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAI 205
             LP +  +KG +V +SS+LGR+     +PY   KF ++ F   LR E+    V V++
Sbjct: 178 SFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSV 235


>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
          Length = 310

 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 43/182 (23%), Positives = 86/182 (47%), Gaps = 9/182 (4%)

Query: 29  GARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADM 88
           G   ++TGA  G+G+  ++  A+ G ++VL + T   L+ +     +     V  I AD 
Sbjct: 48  GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADF 107

Query: 89  ASPEAPESVVQFALDKLGGLDY-LVLNHIGGAP---AGTRARSPQATRWLMQVNFVSYVQ 144
                 + + +   +KL GL+  +++N++G  P         +P   + L+  N  S V+
Sbjct: 108 TK----DDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVK 163

Query: 145 LTSRALPSL-TDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNV 203
           +T   L  + +  KG ++ +SS +   P    + YSA+K  +  F  +L+ E   ++V +
Sbjct: 164 MTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVII 223

Query: 204 AI 205
            +
Sbjct: 224 QV 225


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 52/208 (25%), Positives = 98/208 (47%), Gaps = 8/208 (3%)

Query: 1   MKVLLLTGLGALFFAYYWDDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTA 60
           M + L   +G  +  +++ +    + L+   V +TG ++G G+ LA      G  ++   
Sbjct: 1   MWLYLAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAAC 60

Query: 61  HTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLG--GLDYLVLNHIGG 118
            TE   +++ G      + ++  +  D+   E+  +  Q+  + +   GL  LV N    
Sbjct: 61  LTEKGAEQLRGQT----SDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGIS 116

Query: 119 AP-AGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTP 177
            P A     + Q    ++ VN +  + +T   LP +  ++G +V VSS++GRV + F   
Sbjct: 117 LPTAPNELLTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRV-SLFGGG 175

Query: 178 YSAAKFALDGFFGSLRRELDVQDVNVAI 205
           Y  +K+ ++ F  SLRREL    V VA+
Sbjct: 176 YCISKYGVEAFSDSLRRELSYFGVKVAM 203


>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
          Length = 387

 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 54/181 (29%), Positives = 79/181 (43%), Gaps = 15/181 (8%)

Query: 32  VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVG--NCRKLGAPKVFYIAADMA 89
           VL+TG + G+G  L  +   LG     T     L +   G    R+  +P++  +  D+ 
Sbjct: 85  VLVTGGDCGLGHALCKYLDELG----FTVFAGVLNENGPGAEELRRTCSPRLSVLQMDIT 140

Query: 90  SP----EAPESVVQFALDKLGGLDYLVLNHIG--GAPAGTRARSPQATRWLMQVNFVSYV 143
            P    +A   V     D+  GL + V+N+ G  G P           +  M VNF   V
Sbjct: 141 KPVQIKDAYSKVAAMLQDR--GL-WAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTV 197

Query: 144 QLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNV 203
           ++T   LP L  SKG LV VSS+ G  P      Y ++K A+  F   +R EL    + V
Sbjct: 198 EVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKV 257

Query: 204 A 204
           A
Sbjct: 258 A 258


>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 44/176 (25%), Positives = 88/176 (50%), Gaps = 8/176 (4%)

Query: 32  VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASP 91
           + +TG ++G G   A  + + G H++    TE+    +     +    ++  +  D+  P
Sbjct: 32  IFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE----RLRTVLLDVTDP 87

Query: 92  EAPESVVQFALDKLG--GLDYLVLNH-IGGAPAGTRARSPQATRWLMQVNFVSYVQLTSR 148
           E  +   Q+  +++G  GL  L+ N  + G  A T   + +  R  ++VN    + +T  
Sbjct: 88  ENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLN 147

Query: 149 ALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVA 204
            LP +  ++G ++ VSS+ GR+       Y+ +K+A++GF  SLRR++    V+V+
Sbjct: 148 MLPLVKKAQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVS 202


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.137    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,249,144
Number of Sequences: 37866
Number of extensions: 430916
Number of successful extensions: 1443
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 1338
Number of HSP's gapped (non-prelim): 80
length of query: 286
length of database: 18,247,518
effective HSP length: 101
effective length of query: 185
effective length of database: 14,423,052
effective search space: 2668264620
effective search space used: 2668264620
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.