Search of human proteins with 38327642

Search of human proteins with 38327642

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38327642 WD repeat domain 55 [Homo sapiens]
         (383 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38327642 WD repeat domain 55 [Homo sapiens]                        775   0.0  
gi|26665869 WD repeat domain 51B [Homo sapiens]                        73   4e-13
gi|32189425 WD repeat domain 69 [Homo sapiens]                         72   1e-12
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             69   5e-12
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             69   5e-12
gi|21536371 telomerase-associated protein 1 [Homo sapiens]             69   9e-12
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             68   2e-11
gi|75709220 cleavage stimulation factor subunit 1 [Homo sapiens]       67   2e-11
gi|4557491 cleavage stimulation factor subunit 1 [Homo sapiens]        67   2e-11
gi|75709217 cleavage stimulation factor subunit 1 [Homo sapiens]       67   2e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     65   8e-11
gi|113865883 WD repeat domain 38 [Homo sapiens]                        65   8e-11
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    63   5e-10
gi|16554629 WD repeat domain 5 [Homo sapiens]                          58   1e-08
gi|16554627 WD repeat domain 5 [Homo sapiens]                          58   1e-08
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [...    57   3e-08
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...    57   4e-08
gi|23199987 WD repeat domain 5B [Homo sapiens]                         56   5e-08
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ...    56   6e-08
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom...    54   2e-07
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H...    54   3e-07
gi|55769546 PAK1 interacting protein 1 [Homo sapiens]                  54   3e-07
gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]    53   5e-07
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     50   3e-06
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is...    49   6e-06
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i...    49   6e-06
gi|32699064 WD repeat domain 53 [Homo sapiens]                         49   6e-06
gi|34996489 pleckstrin homology domain interacting protein [Homo...    49   8e-06
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     49   1e-05
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [...    48   1e-05

>gi|38327642 WD repeat domain 55 [Homo sapiens]
          Length = 383

 Score =  775 bits (2001), Expect = 0.0
 Identities = 383/383 (100%), Positives = 383/383 (100%)

Query: 1   MDRTCEERPAEDGSDEEDPDSMEAPTRIRDTPEDIVLEAPASGLAFHPARDLLAAGDVDG 60
           MDRTCEERPAEDGSDEEDPDSMEAPTRIRDTPEDIVLEAPASGLAFHPARDLLAAGDVDG
Sbjct: 1   MDRTCEERPAEDGSDEEDPDSMEAPTRIRDTPEDIVLEAPASGLAFHPARDLLAAGDVDG 60

Query: 61  DVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLER 120
           DVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLER
Sbjct: 61  DVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLER 120

Query: 121 RVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAK 180
           RVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAK
Sbjct: 121 RVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAK 180

Query: 181 KLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWN 240
           KLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWN
Sbjct: 181 KLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWN 240

Query: 241 GFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEE 300
           GFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEE
Sbjct: 241 GFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEE 300

Query: 301 LALSHCGRFLASSGHDQRLKFWDMAQLRAVVVDDYRRRKKKGGPLRALSSKTWSTDDFFA 360
           LALSHCGRFLASSGHDQRLKFWDMAQLRAVVVDDYRRRKKKGGPLRALSSKTWSTDDFFA
Sbjct: 301 LALSHCGRFLASSGHDQRLKFWDMAQLRAVVVDDYRRRKKKGGPLRALSSKTWSTDDFFA 360

Query: 361 GLREEGEDSMAQEEKEETGDDSD 383
           GLREEGEDSMAQEEKEETGDDSD
Sbjct: 361 GLREEGEDSMAQEEKEETGDDSD 383


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 58/258 (22%), Positives = 118/258 (45%), Gaps = 16/258 (6%)

Query: 77  LWSSGHHLKACR---------AVAFSEDGQKLITVSKDKAIHV-LDVEQGQLERRVSKAH 126
           LW+   H +A R         +V FS  G  L + S+D+ + + +  ++G+      KAH
Sbjct: 44  LWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSE--FKAH 101

Query: 127 GAPINSL-LLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLT 185
            AP+ S+    D   LAT  +   I++W   ++  L  + +H  ++      P  +L+++
Sbjct: 102 TAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVS 161

Query: 186 ASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGAT 245
            S D  + I++   ++         G    V     G  +A   S+ T+ +++       
Sbjct: 162 CSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR-VNKL 220

Query: 246 SDRFALRAESIDCM-VPVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALS 304
              + + +  ++C+    + + L T S+DG ++ +++L  R++ ++  HTG PV  ++ S
Sbjct: 221 LQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTG-PVFTVSFS 279

Query: 305 HCGRFLASSGHDQRLKFW 322
             G   AS G D ++  W
Sbjct: 280 KGGELFASGGADTQVLLW 297



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 49/202 (24%), Positives = 84/202 (41%), Gaps = 4/202 (1%)

Query: 39  APASGLAFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQK 98
           AP   + F      LA    D  + V+S   Q    + L+S   H    R   FS DG+ 
Sbjct: 103 APVRSVDFSADGQFLATASEDKSIKVWSMYRQ----RFLYSLYRHTHWVRCAKFSPDGRL 158

Query: 99  LITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKE 158
           +++ S+DK I + D    Q     S + G             +A+      +++WD R  
Sbjct: 159 IVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVN 218

Query: 159 GPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTL 218
             L   + H   +  ++  P+   L+TAS DG L I ++   R     +  +G + +V+ 
Sbjct: 219 KLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSF 278

Query: 219 MKWGKKVACGSSEGTIYLFNWN 240
            K G+  A G ++  + L+  N
Sbjct: 279 SKGGELFASGGADTQVLLWRTN 300


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 59/235 (25%), Positives = 104/235 (44%), Gaps = 6/235 (2%)

Query: 44  LAFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVS 103
           L+F+P   L+A G +D    +  +  Q GE  E+++   H     +++F+  G ++IT S
Sbjct: 183 LSFNPQSTLVATGSMDTTAKL--WDIQNGE--EVYTLRGHSAEIISLSFNTSGDRIITGS 238

Query: 104 KDKAIHVLDVEQGQLERRVSKAHGAPINSLLLV-DENVLATGDDTGGIRLWDQRKEGPLM 162
            D  + V D + G+ +  +   H A I+S     D +++ TG      +LWD      + 
Sbjct: 239 FDHTVVVWDADTGR-KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVA 297

Query: 163 DMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWG 222
            +  H++ I D   D   KL+ TAS DG   IF+   R+     E   G+++ ++    G
Sbjct: 298 TLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG 357

Query: 223 KKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIR 277
             +  GSS+ T  +++               E   C      +++ TGS D   R
Sbjct: 358 NHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 55/251 (21%), Positives = 103/251 (41%), Gaps = 4/251 (1%)

Query: 75  KELWSSGHHLKACRAVAFSED-GQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSL 133
           +EL +   H     A+AF+   G K+ T S DK   +  VE G+      + H A I  L
Sbjct: 125 EELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTF-RGHTAEIVCL 183

Query: 134 LLVDENVL-ATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCL 192
               ++ L ATG      +LWD +    +  +R H   I  ++ + +   ++T S D  +
Sbjct: 184 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTV 243

Query: 193 GIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALR 252
            +++    R   +      +++S +       +  GS + T  L++       +      
Sbjct: 244 VVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHD 303

Query: 253 AESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLAS 312
            E +D     T  L+ T S DG  R  +    + +  +  H GE + +++ +  G  L +
Sbjct: 304 DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGE-ISKISFNPQGNHLLT 362

Query: 313 SGHDQRLKFWD 323
              D+  + WD
Sbjct: 363 GSSDKTARIWD 373


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 59/272 (21%), Positives = 119/272 (43%), Gaps = 9/272 (3%)

Query: 53  LAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLD 112
           LA+G +D  + V+    Q       +    H  A   V FS  G  L + S+DK + +  
Sbjct: 34  LASGSMDSCLMVWHMKPQS----RAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW- 88

Query: 113 VEQGQLERRVSKAHGAPINSL-LLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYI 171
           V   + E  V +AH A + S+    D     T  D   +++W   ++  L  + QH  ++
Sbjct: 89  VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWV 148

Query: 172 ADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSE 231
                 P  +L+++AS D  + +++   R          G +T V     G  +A    +
Sbjct: 149 RCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMD 208

Query: 232 GTIYLFNWNGFGATSDRFALRAESIDCM-VPVTESLLCTGSTDGVIRAVNILPNRVVGSV 290
            T+ +++          + L + +++ +    + + L T S+D  ++ ++++  R++ ++
Sbjct: 209 NTVKVWDVRTHRLLQ-HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 267

Query: 291 GQHTGEPVEELALSHCGRFLASSGHDQRLKFW 322
             H G P   +A S  G + AS G D+++  W
Sbjct: 268 HGHQG-PATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 37/166 (22%), Positives = 66/166 (39%)

Query: 75  KELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLL 134
           K L+S   H+   R   FS DG+ +++ S DK + + D    +      +  G       
Sbjct: 136 KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDF 195

Query: 135 LVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGI 194
                 +A       +++WD R    L   + H   +  ++  P+   L+TAS D  L I
Sbjct: 196 HPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 255

Query: 195 FNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWN 240
            ++   R         G  T+V   + G+  A G S+  + ++  N
Sbjct: 256 LDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301



 Score = 33.1 bits (74), Expect = 0.43
 Identities = 35/164 (21%), Positives = 62/164 (37%), Gaps = 1/164 (0%)

Query: 167 HEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVA 226
           H + +  +      K L + S D CL ++++K +            +T V     G  +A
Sbjct: 18  HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77

Query: 227 CGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRV 286
            GS + T+ ++  N  G ++   A  A               T S D  ++       + 
Sbjct: 78  SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137

Query: 287 VGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFWDMAQLRAV 330
           + S+ QH    V     S  GR + S+  D+ +K WD +    V
Sbjct: 138 LFSLSQHINW-VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 59/272 (21%), Positives = 119/272 (43%), Gaps = 9/272 (3%)

Query: 53  LAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLD 112
           LA+G +D  + V+    Q       +    H  A   V FS  G  L + S+DK + +  
Sbjct: 34  LASGSMDSCLMVWHMKPQS----RAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW- 88

Query: 113 VEQGQLERRVSKAHGAPINSL-LLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYI 171
           V   + E  V +AH A + S+    D     T  D   +++W   ++  L  + QH  ++
Sbjct: 89  VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWV 148

Query: 172 ADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSE 231
                 P  +L+++AS D  + +++   R          G +T V     G  +A    +
Sbjct: 149 RCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMD 208

Query: 232 GTIYLFNWNGFGATSDRFALRAESIDCM-VPVTESLLCTGSTDGVIRAVNILPNRVVGSV 290
            T+ +++          + L + +++ +    + + L T S+D  ++ ++++  R++ ++
Sbjct: 209 NTVKVWDVRTHRLLQ-HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL 267

Query: 291 GQHTGEPVEELALSHCGRFLASSGHDQRLKFW 322
             H G P   +A S  G + AS G D+++  W
Sbjct: 268 HGHQG-PATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 37/166 (22%), Positives = 66/166 (39%)

Query: 75  KELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLL 134
           K L+S   H+   R   FS DG+ +++ S DK + + D    +      +  G       
Sbjct: 136 KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDF 195

Query: 135 LVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGI 194
                 +A       +++WD R    L   + H   +  ++  P+   L+TAS D  L I
Sbjct: 196 HPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 255

Query: 195 FNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWN 240
            ++   R         G  T+V   + G+  A G S+  + ++  N
Sbjct: 256 LDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301



 Score = 33.1 bits (74), Expect = 0.43
 Identities = 35/164 (21%), Positives = 62/164 (37%), Gaps = 1/164 (0%)

Query: 167 HEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVA 226
           H + +  +      K L + S D CL ++++K +            +T V     G  +A
Sbjct: 18  HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77

Query: 227 CGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRV 286
            GS + T+ ++  N  G ++   A  A               T S D  ++       + 
Sbjct: 78  SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137

Query: 287 VGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFWDMAQLRAV 330
           + S+ QH    V     S  GR + S+  D+ +K WD +    V
Sbjct: 138 LFSLSQHINW-VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180


>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
          Length = 2627

 Score = 68.6 bits (166), Expect = 9e-12
 Identities = 61/235 (25%), Positives = 100/235 (42%), Gaps = 5/235 (2%)

Query: 89   AVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTG 148
            AVAFS +GQ+    + +  +++LD+   Q E+ V          L L D+ +  T  D G
Sbjct: 1681 AVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFD-G 1739

Query: 149  GIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELL-SE 207
             + LWD +    ++  + H+  I    L P  +LL T    GCL +++  R +     + 
Sbjct: 1740 LLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTY 1799

Query: 208  PQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLL 267
            P+S  L  V     G+ +A GS  G+I  F  +G   T D  A  A        V   ++
Sbjct: 1800 PKS--LNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVV 1857

Query: 268  CTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFW 322
              G  D ++          + +   H G     L L H G  L ++G D +++ W
Sbjct: 1858 AVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFL-HAGCQLLTAGEDGKVQVW 1911



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 65/297 (21%), Positives = 114/297 (38%), Gaps = 28/297 (9%)

Query: 44   LAFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVS 103
            +AFHP   ++A G   G +  F     +  TK+L + G  +   R +AF+  G  +    
Sbjct: 1806 VAFHPEGQVIATGSWAGSISFFQVDGLK-VTKDLGAPGASI---RTLAFNVPGGVVAVGR 1861

Query: 104  KDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPLMD 163
             D  + +    +G         HG    +L L     L T  + G +++W     G L  
Sbjct: 1862 LDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWS----GSLGR 1917

Query: 164  MRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDL-----TSVTL 218
             R H   +  ++L PA  + L+  GD     +     R   +S    G        +V+ 
Sbjct: 1918 PRGH---LGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSA 1974

Query: 219  MKW--GKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVI 276
            + W   K +  G+ +G++  +        S     R +     +  ++ LL + S D  +
Sbjct: 1975 LAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTV 2034

Query: 277  ----RAVNILPNRVVG-----SVGQHTGEPVEELALSHCGRFLASSGHDQRLKFWDM 324
                R +   P++         +  H G PV   + S  G  LA+ G D+ L  WD+
Sbjct: 2035 QLWPRQLLTRPHKAEDFPCGTELRGHEG-PVSCCSFSTDGGSLATGGRDRSLLCWDV 2090



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 69/276 (25%), Positives = 117/276 (42%), Gaps = 8/276 (2%)

Query: 85   KACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLL-VDENVLAT 143
            K+   VAF  +GQ + T S   +I    V+  ++ + +  A GA I +L   V   V+A 
Sbjct: 1801 KSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLG-APGASIRTLAFNVPGGVVAV 1859

Query: 144  GDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIF--NIKRRR 201
            G     + LW  R+   L     H  ++A      A   LLTA  DG + ++  ++ R R
Sbjct: 1860 GRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPR 1919

Query: 202  FELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVP 261
              L S   S  L SV L   G +VA G     I ++  +     +   AL   ++  +  
Sbjct: 1920 GHLGSLSLSPAL-SVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDV-AVSALAW 1977

Query: 262  VTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKF 321
            ++  +L +G+ DG ++    L    + S+   +      L L+     LAS+  D  ++ 
Sbjct: 1978 LSPKVLVSGAEDGSLQGW-ALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQL 2036

Query: 322  WDMAQL-RAVVVDDYRRRKKKGGPLRALSSKTWSTD 356
            W    L R    +D+    +  G    +S  ++STD
Sbjct: 2037 WPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTD 2072



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 48/190 (25%), Positives = 73/190 (38%), Gaps = 25/190 (13%)

Query: 68   SCQEGETKELWS--SGH-------HLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQL 118
            SC    +  LW   SG        H  A  AVA  E+   +++VS+D  + V D  QG +
Sbjct: 2123 SCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEE--HVVSVSRDGTLKVWD-HQG-V 2178

Query: 119  ERRVSKAHGAPINSLLLVDEN-----------VLATGDDTGGIRLWDQRKEGPLMDMRQH 167
            E     AH  PI+      E            V+  G D G  RLW          +  H
Sbjct: 2179 ELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLD-GATRLWHPLLVCQTHTLLGH 2237

Query: 168  EEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVAC 227
               +   A+     L+LTAS DG + ++ + +   +      S  +T+V     G     
Sbjct: 2238 SGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVS 2297

Query: 228  GSSEGTIYLF 237
            G+  G + L+
Sbjct: 2298 GNQAGELILW 2307



 Score = 32.7 bits (73), Expect = 0.56
 Identities = 48/237 (20%), Positives = 87/237 (36%), Gaps = 40/237 (16%)

Query: 91   AFSEDGQKLITVSKDKAIHVLDVEQGQ---LERRVSKAHGAPINSLLLVDENVLATGDDT 147
            +FS DG  L T  +D+++   DV   +   L       H   +       +N+L +    
Sbjct: 2068 SFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSD 2127

Query: 148  GGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSE 207
            G + LWD      L     H+  ++  A+   ++ +++ S DG L ++           +
Sbjct: 2128 GSVGLWDPESGQRLGQFLGHQSAVS--AVAAVEEHVVSVSRDGTLKVW-----------D 2174

Query: 208  PQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLL 267
             Q  +LTS+            +  G I               A   E      P +E L+
Sbjct: 2175 HQGVELTSIP-----------AHSGPI------------SHCAAAMEPRAAGQPGSELLV 2211

Query: 268  CTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFWDM 324
             T   DG  R  + L      ++  H+G PV   A+S     + ++  D  ++ W +
Sbjct: 2212 VTVGLDGATRLWHPLLVCQTHTLLGHSG-PVRAAAVSETSGLMLTASEDGSVRLWQV 2267


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 53/242 (21%), Positives = 108/242 (44%), Gaps = 5/242 (2%)

Query: 83  HLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSL-LLVDENVL 141
           H  A   V FS  G  L + S+DK + +  V   + E  V +AH A + S+    D    
Sbjct: 22  HKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSF 80

Query: 142 ATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRR 201
            T  D   +++W   ++  L  + QH  ++      P  +L+++AS D  + +++   R 
Sbjct: 81  VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 140

Query: 202 FELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCM-V 260
                    G +T V     G  +A    + T+ +++          + L + +++ +  
Sbjct: 141 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ-HYQLHSAAVNGLSF 199

Query: 261 PVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLK 320
             + + L T S+D  ++ ++++  R++ ++  H G P   +A S  G + AS G D+++ 
Sbjct: 200 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQG-PATTVAFSRTGEYFASGGSDEQVM 258

Query: 321 FW 322
            W
Sbjct: 259 VW 260



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 37/166 (22%), Positives = 66/166 (39%)

Query: 75  KELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLL 134
           K L+S   H+   R   FS DG+ +++ S DK + + D    +      +  G       
Sbjct: 98  KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDF 157

Query: 135 LVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGI 194
                 +A       +++WD R    L   + H   +  ++  P+   L+TAS D  L I
Sbjct: 158 HPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217

Query: 195 FNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWN 240
            ++   R         G  T+V   + G+  A G S+  + ++  N
Sbjct: 218 LDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 263



 Score = 29.6 bits (65), Expect = 4.8
 Identities = 31/142 (21%), Positives = 54/142 (38%), Gaps = 1/142 (0%)

Query: 189 DGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDR 248
           D CL ++++K +            +T V     G  +A GS + T+ ++  N  G ++  
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 249 FALRAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGR 308
            A  A               T S D  ++       + + S+ QH    V     S  GR
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINW-VRCAKFSPDGR 120

Query: 309 FLASSGHDQRLKFWDMAQLRAV 330
            + S+  D+ +K WD +    V
Sbjct: 121 LIVSASDDKTVKLWDKSSRECV 142


>gi|75709220 cleavage stimulation factor subunit 1 [Homo sapiens]
          Length = 431

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 71/283 (25%), Positives = 120/283 (42%), Gaps = 32/283 (11%)

Query: 57  DVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQG 116
           + D DV   S    E ET  + S   H   CR   +S DGQ + T S D +I +LD E  
Sbjct: 84  EFDADVQTMSPEASEYETCYVTS---HKGPCRVATYSRDGQLIATGSADASIKILDTE-- 138

Query: 117 QLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMAL 176
               R+      PI   ++++E      ++   IR            +  H + +  +A 
Sbjct: 139 ----RMLAKSAMPIE--VMMNETAQQNMENHPVIR-----------TLYDHVDEVTCLAF 181

Query: 177 DPAKKLLLTASGDGCLGIFNIK----RRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEG 232
            P +++L + S D  L +F+      +R F+ + E +   L S++    G  +  G+   
Sbjct: 182 HPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEM--LRSISFHPSGDFILVGTQHP 239

Query: 233 TIYLFNWNGFGA-TSDRFALRAESIDCMVPVTES--LLCTGSTDGVIRAVNILPNRVVGS 289
           T+ L++ N F    S     +     C V    S  +  TGS DG I+  + + NR + +
Sbjct: 240 TLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITT 299

Query: 290 VGQ-HTGEPVEELALSHCGRFLASSGHDQRLKFWDMAQLRAVV 331
             + H G  V     S   +++ SSG D   K W+++  R +V
Sbjct: 300 FEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLV 342



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 29/114 (25%), Positives = 50/114 (43%), Gaps = 5/114 (4%)

Query: 44  LAFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVS 103
           LAFHP   +LA+G  D  + +F YS  +   K  +      +  R+++F   G  ++  +
Sbjct: 179 LAFHPTEQILASGSRDYTLKLFDYS--KPSAKRAFKYIQEAEMLRSISFHPSGDFILVGT 236

Query: 104 KDKAIHVLDVEQGQ--LERRVSKAHGAPINSL-LLVDENVLATGDDTGGIRLWD 154
           +   + + D+   Q  +       H   I S+      N+  TG   G I+LWD
Sbjct: 237 QHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWD 290


>gi|4557491 cleavage stimulation factor subunit 1 [Homo sapiens]
          Length = 431

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 71/283 (25%), Positives = 120/283 (42%), Gaps = 32/283 (11%)

Query: 57  DVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQG 116
           + D DV   S    E ET  + S   H   CR   +S DGQ + T S D +I +LD E  
Sbjct: 84  EFDADVQTMSPEASEYETCYVTS---HKGPCRVATYSRDGQLIATGSADASIKILDTE-- 138

Query: 117 QLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMAL 176
               R+      PI   ++++E      ++   IR            +  H + +  +A 
Sbjct: 139 ----RMLAKSAMPIE--VMMNETAQQNMENHPVIR-----------TLYDHVDEVTCLAF 181

Query: 177 DPAKKLLLTASGDGCLGIFNIK----RRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEG 232
            P +++L + S D  L +F+      +R F+ + E +   L S++    G  +  G+   
Sbjct: 182 HPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEM--LRSISFHPSGDFILVGTQHP 239

Query: 233 TIYLFNWNGFGA-TSDRFALRAESIDCMVPVTES--LLCTGSTDGVIRAVNILPNRVVGS 289
           T+ L++ N F    S     +     C V    S  +  TGS DG I+  + + NR + +
Sbjct: 240 TLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITT 299

Query: 290 VGQ-HTGEPVEELALSHCGRFLASSGHDQRLKFWDMAQLRAVV 331
             + H G  V     S   +++ SSG D   K W+++  R +V
Sbjct: 300 FEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLV 342



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 29/114 (25%), Positives = 50/114 (43%), Gaps = 5/114 (4%)

Query: 44  LAFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVS 103
           LAFHP   +LA+G  D  + +F YS  +   K  +      +  R+++F   G  ++  +
Sbjct: 179 LAFHPTEQILASGSRDYTLKLFDYS--KPSAKRAFKYIQEAEMLRSISFHPSGDFILVGT 236

Query: 104 KDKAIHVLDVEQGQ--LERRVSKAHGAPINSL-LLVDENVLATGDDTGGIRLWD 154
           +   + + D+   Q  +       H   I S+      N+  TG   G I+LWD
Sbjct: 237 QHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWD 290


>gi|75709217 cleavage stimulation factor subunit 1 [Homo sapiens]
          Length = 431

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 71/283 (25%), Positives = 120/283 (42%), Gaps = 32/283 (11%)

Query: 57  DVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQG 116
           + D DV   S    E ET  + S   H   CR   +S DGQ + T S D +I +LD E  
Sbjct: 84  EFDADVQTMSPEASEYETCYVTS---HKGPCRVATYSRDGQLIATGSADASIKILDTE-- 138

Query: 117 QLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMAL 176
               R+      PI   ++++E      ++   IR            +  H + +  +A 
Sbjct: 139 ----RMLAKSAMPIE--VMMNETAQQNMENHPVIR-----------TLYDHVDEVTCLAF 181

Query: 177 DPAKKLLLTASGDGCLGIFNIK----RRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEG 232
            P +++L + S D  L +F+      +R F+ + E +   L S++    G  +  G+   
Sbjct: 182 HPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEM--LRSISFHPSGDFILVGTQHP 239

Query: 233 TIYLFNWNGFGA-TSDRFALRAESIDCMVPVTES--LLCTGSTDGVIRAVNILPNRVVGS 289
           T+ L++ N F    S     +     C V    S  +  TGS DG I+  + + NR + +
Sbjct: 240 TLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITT 299

Query: 290 VGQ-HTGEPVEELALSHCGRFLASSGHDQRLKFWDMAQLRAVV 331
             + H G  V     S   +++ SSG D   K W+++  R +V
Sbjct: 300 FEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLV 342



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 29/114 (25%), Positives = 50/114 (43%), Gaps = 5/114 (4%)

Query: 44  LAFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVS 103
           LAFHP   +LA+G  D  + +F YS  +   K  +      +  R+++F   G  ++  +
Sbjct: 179 LAFHPTEQILASGSRDYTLKLFDYS--KPSAKRAFKYIQEAEMLRSISFHPSGDFILVGT 236

Query: 104 KDKAIHVLDVEQGQ--LERRVSKAHGAPINSL-LLVDENVLATGDDTGGIRLWD 154
           +   + + D+   Q  +       H   I S+      N+  TG   G I+LWD
Sbjct: 237 QHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWD 290


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 45/209 (21%), Positives = 97/209 (46%), Gaps = 5/209 (2%)

Query: 125 AHGAPINSLLL--VDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKL 182
           AH + ++SL+L      +LATG D   + LW   K   +M +  H   +  + L+  ++L
Sbjct: 18  AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEEL 77

Query: 183 LLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGF 242
           ++  S  G + +++++  +          ++ S+    +G+ VA GS +  I L++    
Sbjct: 78  IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137

Query: 243 GATSDRFALRAESIDCM-VPVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEEL 301
           G    R+   ++++ C+        L + + D  ++  ++   +++     HTG PV  +
Sbjct: 138 GCVF-RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG-PVNVV 195

Query: 302 ALSHCGRFLASSGHDQRLKFWDMAQLRAV 330
                   LAS   D+ ++FWD+ + + V
Sbjct: 196 EFHPNEYLLASGSSDRTIRFWDLEKFQVV 224


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 57/246 (23%), Positives = 106/246 (43%), Gaps = 5/246 (2%)

Query: 81  GHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPIN-SLLLVDEN 139
           G H     + AFS DGQ L+T S+D  ++  +   GQL  R+   H  P+       D +
Sbjct: 18  GQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG-GHTGPVKFCRFSPDGH 76

Query: 140 VLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKR 199
           + A+      +RLWD  +   L  ++ H+  +  ++  P  + L +   D  + +++++ 
Sbjct: 77  LFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQS 136

Query: 200 RRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAES--ID 257
            +   L       + S         +A GS + T+++++           AL   S  I 
Sbjct: 137 GQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANIS 196

Query: 258 CMVPVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQ 317
           C+      LL +GS D  I       + ++  +  H    V+ +A S    +LAS+G+ +
Sbjct: 197 CLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHV-TWVKSIAFSPDELWLASAGYSR 255

Query: 318 RLKFWD 323
            +K WD
Sbjct: 256 MVKVWD 261



 Score = 37.4 bits (85), Expect = 0.023
 Identities = 21/67 (31%), Positives = 35/67 (52%), Gaps = 1/67 (1%)

Query: 266 LLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFWDMA 325
           +L TGS DG +        +++  +G HTG PV+    S  G   AS+  D  ++ WD+A
Sbjct: 35  MLLTGSEDGCVYGWETRSGQLLWRLGGHTG-PVKFCRFSPDGHLFASASCDCTVRLWDVA 93

Query: 326 QLRAVVV 332
           + + + V
Sbjct: 94  RAKCLRV 100



 Score = 30.8 bits (68), Expect = 2.1
 Identities = 28/119 (23%), Positives = 48/119 (40%), Gaps = 11/119 (9%)

Query: 211 GDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESID-----CMVPVTES 265
           G++ S      G+ +  GS +G +Y     G+   S +   R          C       
Sbjct: 22  GEVNSSAFSPDGQMLLTGSEDGCVY-----GWETRSGQLLWRLGGHTGPVKFCRFSPDGH 76

Query: 266 LLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFWDM 324
           L  + S D  +R  ++   + +  +  H    VE ++ S   R LAS G D+R+  WD+
Sbjct: 77  LFASASCDCTVRLWDVARAKCLRVLKGHQ-RSVETVSFSPDSRQLASGGWDKRVMLWDV 134


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 56/285 (19%), Positives = 119/285 (41%), Gaps = 18/285 (6%)

Query: 46  FHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKD 105
           FHP    LA+   D  + +++     G+     +   H  A   + ++ DG  L + S D
Sbjct: 74  FHPNGSTLASAGFDRLILLWNVY---GDCDNYATLKGHSGAVMELHYNTDGSMLFSASTD 130

Query: 106 KAIHVLDVEQGQLERRVSKAHGAPINSLLLVDEN--VLATGDDTGGIRLWDQRKEGPLMD 163
           K + V D E G+  +R+ K H + +NS         ++ TG D G ++LWD RK+  +  
Sbjct: 131 KTVAVWDSETGERVKRL-KGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT 189

Query: 164 MRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGK 223
            +   + +A +  +     +++   D  + ++++++ +        +  +T ++L   G 
Sbjct: 190 FQNTYQVLA-VTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGS 248

Query: 224 KVACGSSEGTIYLFNWNGFGATSDRFA---------LRAESIDCMVPVTESLLCTGSTDG 274
            +   + + T+ +++   F A  +R                + C      S +  GS D 
Sbjct: 249 YLLSNAMDNTVRVWDVRPF-APKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADR 307

Query: 275 VIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRL 319
            +   +    R++  +  H G  + E+A       + S+  D+RL
Sbjct: 308 FVYVWDTTSRRILYKLPGHAGS-INEVAFHPDEPIIISASSDKRL 351


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 54/245 (22%), Positives = 99/245 (40%), Gaps = 44/245 (17%)

Query: 83  HLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLV-DENVL 141
           H KA  +V FS +G+ L + S DK I +     G+ E+ +S  H   I+ +    D N+L
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-GHKLGISDVAWSSDSNLL 102

Query: 142 ATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRR 201
            +  D   +++WD      L  ++ H  Y+     +P   L+++ S D  + I+++K  +
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162

Query: 202 FELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVP 261
             L + P   D  S                     FN +G                    
Sbjct: 163 C-LKTLPAHSDPVSAV------------------HFNRDG-------------------- 183

Query: 262 VTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKF 321
              SL+ + S DG+ R  +    + + ++      PV  +  S  G+++ ++  D  LK 
Sbjct: 184 ---SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240

Query: 322 WDMAQ 326
           WD ++
Sbjct: 241 WDYSK 245



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 64/336 (19%), Positives = 140/336 (41%), Gaps = 28/336 (8%)

Query: 6   EERPAEDGSDEEDPDSMEAPTRIRDTP--EDIVLEAPASG-------LAFHPARDLLAAG 56
           EE+  E  +    P    + T+ + TP   +  L+   +G       + F P  + LA+ 
Sbjct: 4   EEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASS 63

Query: 57  DVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQG 116
             D  + +  +   +G+ ++   SGH L     VA+S D   L++ S DK + + DV  G
Sbjct: 64  SADKLIKI--WGAYDGKFEKT-ISGHKL-GISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119

Query: 117 QLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMAL 176
           +  + +                N++ +G     +R+WD +    L  +  H + ++ +  
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179

Query: 177 DPAKKLLLTASGDGCLGIFNIKRRR-FELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIY 235
           +    L++++S DG   I++    +  + L +  +  ++ V     GK +   + + T+ 
Sbjct: 180 NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLK 239

Query: 236 LFNWNG-------FGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVG 288
           L++++         G  ++++ + A             + +GS D ++   N+    +V 
Sbjct: 240 LWDYSKGKCLKTYTGHKNEKYCIFAN----FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295

Query: 289 SVGQHTGEPVEELALSHCGRFLASSG--HDQRLKFW 322
            +  HT + V   A       +AS+   +D+ +K W
Sbjct: 296 KLQGHT-DVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 35.4 bits (80), Expect = 0.087
 Identities = 30/171 (17%), Positives = 69/171 (40%), Gaps = 4/171 (2%)

Query: 167 HEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVA 226
           H + ++ +   P  + L ++S D  + I+     +FE         ++ V        + 
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103

Query: 227 CGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRV 286
             S + T+ +++ +                 C      +L+ +GS D  +R  ++   + 
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163

Query: 287 VGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFWDMAQ---LRAVVVDD 334
           + ++  H+ +PV  +  +  G  + SS +D   + WD A    L+ ++ DD
Sbjct: 164 LKTLPAHS-DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 54/245 (22%), Positives = 99/245 (40%), Gaps = 44/245 (17%)

Query: 83  HLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLV-DENVL 141
           H KA  +V FS +G+ L + S DK I +     G+ E+ +S  H   I+ +    D N+L
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-GHKLGISDVAWSSDSNLL 102

Query: 142 ATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRR 201
            +  D   +++WD      L  ++ H  Y+     +P   L+++ S D  + I+++K  +
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162

Query: 202 FELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVP 261
             L + P   D  S                     FN +G                    
Sbjct: 163 C-LKTLPAHSDPVSAV------------------HFNRDG-------------------- 183

Query: 262 VTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKF 321
              SL+ + S DG+ R  +    + + ++      PV  +  S  G+++ ++  D  LK 
Sbjct: 184 ---SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240

Query: 322 WDMAQ 326
           WD ++
Sbjct: 241 WDYSK 245



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 64/336 (19%), Positives = 140/336 (41%), Gaps = 28/336 (8%)

Query: 6   EERPAEDGSDEEDPDSMEAPTRIRDTP--EDIVLEAPASG-------LAFHPARDLLAAG 56
           EE+  E  +    P    + T+ + TP   +  L+   +G       + F P  + LA+ 
Sbjct: 4   EEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASS 63

Query: 57  DVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQG 116
             D  + +  +   +G+ ++   SGH L     VA+S D   L++ S DK + + DV  G
Sbjct: 64  SADKLIKI--WGAYDGKFEKT-ISGHKL-GISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119

Query: 117 QLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMAL 176
           +  + +                N++ +G     +R+WD +    L  +  H + ++ +  
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179

Query: 177 DPAKKLLLTASGDGCLGIFNIKRRR-FELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIY 235
           +    L++++S DG   I++    +  + L +  +  ++ V     GK +   + + T+ 
Sbjct: 180 NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLK 239

Query: 236 LFNWNG-------FGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVG 288
           L++++         G  ++++ + A             + +GS D ++   N+    +V 
Sbjct: 240 LWDYSKGKCLKTYTGHKNEKYCIFAN----FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295

Query: 289 SVGQHTGEPVEELALSHCGRFLASSG--HDQRLKFW 322
            +  HT + V   A       +AS+   +D+ +K W
Sbjct: 296 KLQGHT-DVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 35.4 bits (80), Expect = 0.087
 Identities = 30/171 (17%), Positives = 69/171 (40%), Gaps = 4/171 (2%)

Query: 167 HEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVA 226
           H + ++ +   P  + L ++S D  + I+     +FE         ++ V        + 
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103

Query: 227 CGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRV 286
             S + T+ +++ +                 C      +L+ +GS D  +R  ++   + 
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163

Query: 287 VGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFWDMAQ---LRAVVVDD 334
           + ++  H+ +PV  +  +  G  + SS +D   + WD A    L+ ++ DD
Sbjct: 164 LKTLPAHS-DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213


>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
           [Homo sapiens]
          Length = 340

 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 59/247 (23%), Positives = 106/247 (42%), Gaps = 21/247 (8%)

Query: 45  AFHPARDLLAAGDVDGDVFVFSYSCQEGE---TKELWSSGHHLKACRAVAFSEDGQKLIT 101
           A+ P+ + +A G +D    +++   +EG    ++EL     +L  CR   F +D Q ++T
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR---FLDDNQ-IVT 159

Query: 102 VSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPL 161
            S D    + D+E GQ     +   G  ++  L  D  +  +G      +LWD R+    
Sbjct: 160 SSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219

Query: 162 MDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSG---DLTSVTL 218
                HE  I  +   P      T S D    +F+++  + EL++         +TSV+ 
Sbjct: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQ-ELMTYSHDNIICGITSVSF 278

Query: 219 MKWGKKVACGSSEGTIYLFNWNGFGA-TSDRFALRA---ESIDCMVPVTESL-LCTGSTD 273
            K G+ +  G  +     FN N + A  +DR  + A     + C+    + + + TGS D
Sbjct: 279 SKSGRLLLAGYDD-----FNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333

Query: 274 GVIRAVN 280
             ++  N
Sbjct: 334 SFLKIWN 340


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 21/247 (8%)

Query: 45  AFHPARDLLAAGDVDGDVFVFSYSCQEGE---TKELWSSGHHLKACRAVAFSEDGQKLIT 101
           A+ P+ + +A G +D    ++S   +EG    ++EL     +L  CR   F +D Q +IT
Sbjct: 104 AYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCR---FLDDNQ-IIT 159

Query: 102 VSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPL 161
            S D    + D+E GQ     +   G  ++  L  D     +G     I+LWD R     
Sbjct: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCR 219

Query: 162 MDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSG---DLTSVTL 218
                HE  I  +A  P      T S D    +F+++  + ELL          +TSV  
Sbjct: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQ-ELLMYSHDNIICGITSVAF 278

Query: 219 MKWGKKVACGSSEGTIYLFNWNGFGA-TSDRFALRA---ESIDCMVPVTESL-LCTGSTD 273
            + G+ +  G  +     FN N + A   DR  + A     + C+    + + + TGS D
Sbjct: 279 SRSGRLLLAGYDD-----FNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333

Query: 274 GVIRAVN 280
             ++  N
Sbjct: 334 SFLKIWN 340


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 53/249 (21%), Positives = 100/249 (40%), Gaps = 44/249 (17%)

Query: 83  HLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLV-DENVL 141
           H +A  +V FS +G+ L + S D+ I +     G+ E+ +   H   I+ +    D + L
Sbjct: 40  HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLY-GHNLEISDVAWSSDSSRL 98

Query: 142 ATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRR 201
            +  D   ++LWD R    L  ++ H  Y+     +P   L+++ S D  + I+ +K   
Sbjct: 99  VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG- 157

Query: 202 FELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVP 261
                             K  K ++  S   +   FN +G                    
Sbjct: 158 ------------------KCLKTLSAHSDPVSAVHFNCSG-------------------- 179

Query: 262 VTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKF 321
              SL+ +GS DG+ R  +    + + ++      PV  +  S  G+++ ++  D  LK 
Sbjct: 180 ---SLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKL 236

Query: 322 WDMAQLRAV 330
           WD ++ R +
Sbjct: 237 WDYSRGRCL 245



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 56/297 (18%), Positives = 126/297 (42%), Gaps = 31/297 (10%)

Query: 42  SGLAFHPARDLLAAGDVDGDVFVFSYSCQEGE-TKELWSSGHHLKACRAVAFSEDGQKLI 100
           S + F P  + LA+   D  + +  +   +G+  K L+  GH+L+    VA+S D  +L+
Sbjct: 45  SSVKFSPNGEWLASSSADRLIII--WGAYDGKYEKTLY--GHNLEISD-VAWSSDSSRLV 99

Query: 101 TVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGP 160
           + S DK + + DV  G+  + +                N++ +G     +++W+ +    
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159

Query: 161 LMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRR-FELLSEPQSGDLTSVTLM 219
           L  +  H + ++ +  + +  L+++ S DG   I++    +  + L +  +  ++ V   
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFS 219

Query: 220 KWGKKVACGSSEGTIYLFNWNG-------FGATSDRFALRAESIDCMVPVTESLLCTGST 272
             GK +   + + T+ L++++         G  ++++ + A             + +GS 
Sbjct: 220 PNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFAN----FSVTGGKWIVSGSE 275

Query: 273 DGVIRAVNILPNRVVGSVGQHTG-------EPVEELALSHCGRFLASSGHDQRLKFW 322
           D ++   N+    +V  +  HT         P E L  S      A+  +D+ +K W
Sbjct: 276 DNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIAS------AALENDKTIKLW 326


>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
           sapiens]
          Length = 513

 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 66/293 (22%), Positives = 119/293 (40%), Gaps = 19/293 (6%)

Query: 46  FHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLK----ACRAVAFSEDGQKLIT 101
           F P    L  G VDG + V++++  +      + +  +      A   + FS D + L T
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281

Query: 102 VSKDKAIHVLDVEQGQLERRVSKAHGAPINSL-LLVDENVLATGDDTGGIRLWDQRKEGP 160
            ++D  I V  ++ GQ  RR  +AH   +  L    D + + +      IR+   +    
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341

Query: 161 LMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIK----RRRFELLSEPQSGDLT-- 214
           L + R H  ++ +         +++AS DG + I+N+K       F+ L      D+T  
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVN 401

Query: 215 SVTLMKWGKK--VACGSSEGTIYLFNWNGFGATSDRFALR--AESIDC-MVPVTESLLCT 269
           SV L+    +  V C  S  T+ + N  G    S     R   + + C + P  E + C 
Sbjct: 402 SVILLPKNPEHFVVCNRS-NTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCV 460

Query: 270 GSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFW 322
           G  D V+   + +  ++  ++  H  + +      H    +A+   D  LK W
Sbjct: 461 GE-DFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPH-QNLIATYSEDGLLKLW 511


>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
           sapiens]
          Length = 504

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 46/211 (21%), Positives = 93/211 (44%), Gaps = 10/211 (4%)

Query: 126 HGAPINSLLLVD-----ENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAK 180
           H A I  +L +D      N + TG     + ++D+  E  L  ++ H + +  +   P++
Sbjct: 217 HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQ 276

Query: 181 KLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWN 240
            L+ +AS D  + I+++       +       +T ++L   G  +   SS+   + F+  
Sbjct: 277 DLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLL-SSSDDQYWAFSDI 335

Query: 241 GFGATSDRFALRAE--SIDCMVPVTESLLC-TGSTDGVIRAVNILPNRVVGSVGQHTGEP 297
             G    +        S+ C     + L+  TG+ D  I+  ++     V +   H+G P
Sbjct: 336 QTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSG-P 394

Query: 298 VEELALSHCGRFLASSGHDQRLKFWDMAQLR 328
           +  +A S  G +LA++  D  +K WD+ +L+
Sbjct: 395 ITSIAFSENGYYLATAADDSSVKLWDLRKLK 425



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 40/201 (19%), Positives = 91/201 (45%), Gaps = 13/201 (6%)

Query: 42  SGLAFHPARDLLAAGDVDGDVFVFSY---SCQEGETKELWSSGHHLKACRAVAFSEDGQK 98
           + + FHP++DL+ +   D  + ++S    SC +           H  A   ++    G  
Sbjct: 268 TSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRA-------HESAVTGLSLHATGDY 320

Query: 99  LITVSKDKAIHVLDVEQGQLERRVS-KAHGAPIN-SLLLVDENVLATGDDTGGIRLWDQR 156
           L++ S D+     D++ G++  +V+ +  G  +  +    D  +  TG     I++WD +
Sbjct: 321 LLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLK 380

Query: 157 KEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKR-RRFELLSEPQSGDLTS 215
           +   + +   H   I  +A       L TA+ D  + ++++++ + F+ L    + ++ S
Sbjct: 381 ERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKS 440

Query: 216 VTLMKWGKKVACGSSEGTIYL 236
           +   + G  +A G ++  IY+
Sbjct: 441 LIFDQSGTYLALGGTDVQIYI 461



 Score = 30.8 bits (68), Expect = 2.1
 Identities = 29/153 (18%), Positives = 61/153 (39%), Gaps = 7/153 (4%)

Query: 46  FHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKD 105
           FHP   +   G +D  + ++       E   + +   H     ++AFSE+G  L T + D
Sbjct: 358 FHPDGLIFGTGTMDSQIKIWDLK----ERTNVANFPGHSGPITSIAFSENGYYLATAADD 413

Query: 106 KAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENV-LATGDDTGGIRLWDQRKEGPLMDM 164
            ++ + D+ + +  + +   +   + SL+       LA G     I +  Q  E  ++  
Sbjct: 414 SSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTE--ILHF 471

Query: 165 RQHEEYIADMALDPAKKLLLTASGDGCLGIFNI 197
            +H      +A     K + +   D  L  +++
Sbjct: 472 TEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504


>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
           sapiens]
          Length = 340

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 57/247 (23%), Positives = 106/247 (42%), Gaps = 21/247 (8%)

Query: 45  AFHPARDLLAAGDVDGDVFVFSYSCQEGETK---ELWSSGHHLKACRAVAFSEDGQKLIT 101
           A+ P+ + +A G +D    +++   +EG  K   EL +   +L  CR +    D   ++T
Sbjct: 104 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFL----DDNNIVT 159

Query: 102 VSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLV-DENVLATGDDTGGIRLWDQRKEGP 160
            S D    + D+E GQ ++ V   H     SL +  D N+  +G      +LWD R+   
Sbjct: 160 SSGDTTCALWDIETGQ-QKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTC 218

Query: 161 LMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQS--GDLTSVTL 218
                 HE  I  +   P  + + T S D    +F+++  +  +    +S    +TSV  
Sbjct: 219 RQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAF 278

Query: 219 MKWGKKVACGSSEGTIYLFNWNGFGA-TSDRFALRA---ESIDCMVPVTESL-LCTGSTD 273
              G+ +  G  +     FN N + +  S+R  + +     + C+    + + + TGS D
Sbjct: 279 SLSGRLLFAGYDD-----FNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWD 333

Query: 274 GVIRAVN 280
             ++  N
Sbjct: 334 SFLKIWN 340


>gi|55769546 PAK1 interacting protein 1 [Homo sapiens]
          Length = 392

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 39/159 (24%), Positives = 70/159 (44%), Gaps = 16/159 (10%)

Query: 43  GLAFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITV 102
           G A HP  +  A GD +    V  ++             HH       A + + + ++T 
Sbjct: 14  GFAVHPEPE--ACGDHEQWTLVADFT-------------HHAHTASLSAVAVNSRFVVTG 58

Query: 103 SKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPLM 162
           SKD+ IH+ D+++ ++E      H   I  L       L +G + G I +WD +K   L 
Sbjct: 59  SKDETIHIYDMKK-KIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLK 117

Query: 163 DMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRR 201
            ++ H+  +  +++ P+ KL L+   D  L  +N+   R
Sbjct: 118 SIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGR 156



 Score = 37.0 bits (84), Expect = 0.030
 Identities = 37/161 (22%), Positives = 76/161 (47%), Gaps = 16/161 (9%)

Query: 44  LAFHPARDLLAAGDVDGDVFVFSYSCQEGET---KELWSSGHHLKACRAVAFSEDGQKLI 100
           L+ HP+  L  A  V  D  + +++  EG +   K +  + H       V +S  G++ +
Sbjct: 129 LSIHPSGKL--ALSVGTDKTLRTWNLVEGRSAFIKNIKQNAH------IVEWSPRGEQYV 180

Query: 101 TVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGP 160
            + ++K I +  ++   +   ++      I+S+  + E+VLA   D   IR +D      
Sbjct: 181 VIIQNK-IDIYQLDTASISGTITNEKR--ISSVKFLSESVLAVAGDEEVIRFFDCDSLVC 237

Query: 161 LMDMRQHEEYIADMAL--DPAKKLLLTASGDGCLGIFNIKR 199
           L + + HE  + DM     P   ++++AS DG + ++ +K+
Sbjct: 238 LCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQ 278


>gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]
          Length = 919

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 52/246 (21%), Positives = 103/246 (41%), Gaps = 18/246 (7%)

Query: 89  AVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGD--- 145
           A AF +    L+T       H+ ++ +  L       H   I+   +    + ++GD   
Sbjct: 293 AAAFHKKSHLLVTGFASGIFHLHELPEFNL------IHSLSISDQSIASVAINSSGDWIA 346

Query: 146 ----DTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFN-IKRR 200
                 G + +W+ + E  ++  + H   +  +A  P  + ++T   DG + ++N +   
Sbjct: 347 FGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGF 406

Query: 201 RFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCM- 259
            F   +E  SG +T VT    G  V   S +GT+  F+ + +       + R     C+ 
Sbjct: 407 CFVTFTEHSSG-VTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVA 465

Query: 260 VPVTESLLCTGSTDGV-IRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQR 318
           V  +  ++  G+ D   I   ++   R++  +  H G P+  L  +     LAS+  D+ 
Sbjct: 466 VDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEG-PISGLCFNPMKSVLASASWDKT 524

Query: 319 LKFWDM 324
           ++ WDM
Sbjct: 525 VRLWDM 530



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 47/219 (21%), Positives = 94/219 (42%), Gaps = 12/219 (5%)

Query: 113 VEQGQLERRVSKAHGAPINSLLLV----DENVLATGDDTGGIRLWDQRKEGPLMDMRQHE 168
           V + Q E  V K  G   NS++ +    D   + TG D G +++W+       +   +H 
Sbjct: 357 VWEWQSESYVLKQQGH-FNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHS 415

Query: 169 EYIADMALDPAKKLLLTASGDGCLGIFNIKR-RRFELLSEPQSGDLTSVTLMKWGKKVAC 227
             +  +       +++T+S DG +  F++ R R F   + P+    + V +   G+ V+ 
Sbjct: 416 SGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSA 475

Query: 228 GSSEGTIYLFNWN-GFGATSDRFALRAESID--CMVPVTESLLCTGSTDGVIRAVNILPN 284
           G+ + +  +F W+   G   D  +     I   C  P+ +S+L + S D  +R  ++  +
Sbjct: 476 GAQD-SFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPM-KSVLASASWDKTVRLWDMFDS 533

Query: 285 RVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFWD 323
                    T + +  +     G  LA +  + ++ FWD
Sbjct: 534 WRTKETLALTSDAL-AVTFRPDGAELAVATLNSQITFWD 571



 Score = 31.6 bits (70), Expect = 1.3
 Identities = 28/90 (31%), Positives = 40/90 (44%), Gaps = 12/90 (13%)

Query: 38  EAPASGLAFHPARDLLAAGDVDGDVFVFSY--SCQEGETKELWSSGHHLKACRAVAFSED 95
           E P SGL F+P + +LA+   D  V ++    S +  ET  L S         AV F  D
Sbjct: 501 EGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSD------ALAVTFRPD 554

Query: 96  GQKLITVSKDKAIHVLD----VEQGQLERR 121
           G +L   + +  I   D    V+ G +E R
Sbjct: 555 GAELAVATLNSQITFWDPENAVQTGSIEGR 584


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 31/78 (39%), Positives = 41/78 (52%), Gaps = 2/78 (2%)

Query: 249 FALRAESIDCM-VPVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCG 307
           +A     +DC+      + L TGSTD  +R  +      V     H G PV  LA S  G
Sbjct: 422 YAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRG-PVLSLAFSPNG 480

Query: 308 RFLASSGHDQRLKFWDMA 325
           ++LAS+G DQRLK WD+A
Sbjct: 481 KYLASAGEDQRLKLWDLA 498



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 39/177 (22%), Positives = 69/177 (38%), Gaps = 4/177 (2%)

Query: 40  PASGLAFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKL 99
           P   L   P     A+G  D    ++S+      T  L     HL     V F  +   L
Sbjct: 386 PVWDLDISPYSLYFASGSHDRTARLWSFD----RTYPLRIYAGHLADVDCVKFHPNSNYL 441

Query: 100 ITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEG 159
            T S DK + +   +QG   R  +   G  ++     +   LA+  +   ++LWD     
Sbjct: 442 ATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGT 501

Query: 160 PLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSV 216
              ++R H + I  +   P   L+ +AS D  + +++I+       ++  S +L  V
Sbjct: 502 LYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGV 558



 Score = 29.6 bits (65), Expect = 4.8
 Identities = 33/158 (20%), Positives = 61/158 (38%), Gaps = 4/158 (2%)

Query: 83  HLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVS-KAHGAPINSLLLVDENV- 140
           H     +  F  D   L++ S+D +I   D+  G     V  + H  P+  L +   ++ 
Sbjct: 341 HCGPVYSTRFLADSSGLLSCSEDMSIRYWDL--GSFTNTVLYQGHAYPVWDLDISPYSLY 398

Query: 141 LATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRR 200
            A+G      RLW   +  PL     H   +  +   P    L T S D  + +++ ++ 
Sbjct: 399 FASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQG 458

Query: 201 RFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFN 238
               L     G + S+     GK +A    +  + L++
Sbjct: 459 NSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD 496


>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
           isoform a [Homo sapiens]
          Length = 353

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 64/283 (22%), Positives = 99/283 (34%), Gaps = 47/283 (16%)

Query: 45  AFHPARDLLAAGDVDG--DVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITV 102
           A+ P+   +A G +D    V+  ++   E    +  S   H     A +F+    +++T 
Sbjct: 112 AYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTA 171

Query: 103 SKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDE---NVLATGDDTGGIRLWDQRKEG 159
           S D    + DVE GQL +     HGA +  L L      N   +G       +WD R   
Sbjct: 172 SGDGTCALWDVESGQLLQSF-HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQ 230

Query: 160 PLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLM 219
            +     HE  I  +   P+     + S D    +++++  R                  
Sbjct: 231 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADR------------------ 272

Query: 220 KWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAV 279
               +VA  S E  I       FGA+S  F+L              LL  G  D  I   
Sbjct: 273 ----EVAIYSKESII-------FGASSVDFSLSGR-----------LLFAGYNDYTINVW 310

Query: 280 NILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFW 322
           ++L    V  +  H    V  L +S  G    S   D  L+ W
Sbjct: 311 DVLKGSRVSILFGHENR-VSTLRVSPDGTAFCSGSWDHTLRVW 352


>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
           isoform b [Homo sapiens]
          Length = 395

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 64/283 (22%), Positives = 99/283 (34%), Gaps = 47/283 (16%)

Query: 45  AFHPARDLLAAGDVDG--DVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITV 102
           A+ P+   +A G +D    V+  ++   E    +  S   H     A +F+    +++T 
Sbjct: 154 AYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTA 213

Query: 103 SKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDE---NVLATGDDTGGIRLWDQRKEG 159
           S D    + DVE GQL +     HGA +  L L      N   +G       +WD R   
Sbjct: 214 SGDGTCALWDVESGQLLQSF-HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQ 272

Query: 160 PLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLM 219
            +     HE  I  +   P+     + S D    +++++  R                  
Sbjct: 273 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADR------------------ 314

Query: 220 KWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVIRAV 279
               +VA  S E  I       FGA+S  F+L              LL  G  D  I   
Sbjct: 315 ----EVAIYSKESII-------FGASSVDFSLSGR-----------LLFAGYNDYTINVW 352

Query: 280 NILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFW 322
           ++L    V  +  H    V  L +S  G    S   D  L+ W
Sbjct: 353 DVLKGSRVSILFGHENR-VSTLRVSPDGTAFCSGSWDHTLRVW 394


>gi|32699064 WD repeat domain 53 [Homo sapiens]
          Length = 358

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 53/210 (25%), Positives = 87/210 (41%), Gaps = 22/210 (10%)

Query: 89  AVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVD-ENVLATGDDT 147
           +V FS      +  S  + I VLDV   +        +   IN L L   EN+LA+ DD+
Sbjct: 56  SVLFSPSCPTKLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDS 115

Query: 148 GGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGC------------LGIF 195
           G I++ D   +  +  +++H    + +A  P +   L + G               L I 
Sbjct: 116 GAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWIT 175

Query: 196 NIKRRRFELLSEPQS-GDLT------SVTLMKWGKKVACGSSEGTIYLFNWNGFGATSD- 247
           N++    E +  PQS G L       S+++   G   +CG+ +G + +F   G     + 
Sbjct: 176 NLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQEL 235

Query: 248 RFALRAESIDCMVPVTES-LLCTGSTDGVI 276
            F      +  +  + ES LL TG  DG I
Sbjct: 236 GFKGHTSGVSQVCFLPESYLLLTGGNDGKI 265


>gi|34996489 pleckstrin homology domain interacting protein [Homo
           sapiens]
          Length = 1821

 Score = 48.9 bits (115), Expect = 8e-06
 Identities = 49/210 (23%), Positives = 86/210 (40%), Gaps = 16/210 (7%)

Query: 83  HLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDEN-VL 141
           HL +   V F   G+++ T S D  + +   + G+L   + + H A I+ + +  EN ++
Sbjct: 182 HLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATL-RGHAAEISDMAVNYENTMI 240

Query: 142 ATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDP----AKKLLLTASGDGCL----- 192
           A G     IR+W  R   PL  ++ H   I  +   P    +K+ L +   DG +     
Sbjct: 241 AAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLW 300

Query: 193 --GIFNIKRRRFELLSEPQSG-DLTSVTLMKWGKKVACGSSEGTIYL-FNWNGFGATSDR 248
             G   I  R  +    P+ G  +   +    G  +A GS++  I + F  +G       
Sbjct: 301 DAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISE 360

Query: 249 FALRAESIDCM-VPVTESLLCTGSTDGVIR 277
                + +D +    T +   +GS DG  R
Sbjct: 361 LEFHTDKVDSIQFSNTSNRFVSGSRDGTAR 390



 Score = 33.5 bits (75), Expect = 0.33
 Identities = 40/194 (20%), Positives = 76/194 (39%), Gaps = 15/194 (7%)

Query: 143 TGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRF 202
           TG D   +++W       L  +R H   I+DMA++    ++   S D  + ++ ++    
Sbjct: 200 TGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAP 259

Query: 203 ELLSEPQSGDLTSV---TLMKWGKK-VACGSSEGTIYLFNWNG----FGATSDRFALR-- 252
             + +  S  +TS+    L    K+ ++   ++GTI  + W+           +F  R  
Sbjct: 260 LAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPR 319

Query: 253 --AESIDCMVPVTESLLCTGSTDGVIRAVNILPNR--VVGSVGQHTGEPVEELALSHCGR 308
              + I          L TGSTD +IR       +   +  +  HT + V+ +  S+   
Sbjct: 320 PGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHT-DKVDSIQFSNTSN 378

Query: 309 FLASSGHDQRLKFW 322
              S   D   + W
Sbjct: 379 RFVSGSRDGTARIW 392


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 63/274 (22%), Positives = 104/274 (37%), Gaps = 10/274 (3%)

Query: 53  LAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLD 112
           L A DV  D  + +    +  T  +WS     K  R+V  + D   +   S D    ++D
Sbjct: 473 LTAVDVTDDSSLIAGGFADS-TVRVWSVTP--KKLRSVKQASDLSLIDKESDDVLERIMD 529

Query: 113 VEQGQLERRVSKAHGAPI-NSLLLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYI 171
            E+   E ++   H  P+  +    D N L +  + G +RLW  +    L+  + H   +
Sbjct: 530 -EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPV 588

Query: 172 ADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSE 231
            D    P     ++   D    ++     +   +      D+           VA GS++
Sbjct: 589 WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSAD 648

Query: 232 GTIYLFNWNGFGATSDR-FALRAESIDCMV-PVTESLLCTGSTDGVIRAVNILPNRVVGS 289
            T+ L  W+       R F      I  +        L TG+TDG +   +I    +VG 
Sbjct: 649 RTVRL--WDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE 706

Query: 290 VGQHTGEPVEELALSHCGRFLASSGHDQRLKFWD 323
           +  HT + V  L  S  G  LAS   D  ++ WD
Sbjct: 707 LKGHT-DTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 54/243 (22%), Positives = 97/243 (39%), Gaps = 23/243 (9%)

Query: 15  DEEDPDSMEAPTRIRDTPEDIVL---EAPASGLAFHPARDLLAAGDVDGDVFVFS---YS 68
           D+E  D +E     +   E  +L     P  G +F P R+ L +   DG V ++S   ++
Sbjct: 517 DKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576

Query: 69  C---QEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKA 125
           C    +G    +W +           FS  G   ++   D+   +   +  Q   R+   
Sbjct: 577 CLVGYKGHNYPVWDT----------QFSPYGYYFVSGGHDRVARLWATDHYQ-PLRIFAG 625

Query: 126 HGAPINSLLL-VDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLL 184
           H A +N      + N +ATG     +RLWD      +     H+  I  +   P  + L 
Sbjct: 626 HLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLA 685

Query: 185 TASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGA 244
           T + DG + +++I         +  +  + S+   + G+ +A GS + T+ L  W+   A
Sbjct: 686 TGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRL--WDAIKA 743

Query: 245 TSD 247
             D
Sbjct: 744 FED 746



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 51/237 (21%), Positives = 95/237 (40%), Gaps = 14/237 (5%)

Query: 89  AVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTG 148
           AV  ++D   +     D  + V  V   +L R V +A     + L L+D+       D  
Sbjct: 475 AVDVTDDSSLIAGGFADSTVRVWSVTPKKL-RSVKQA-----SDLSLIDKE-----SDDV 523

Query: 149 GIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEP 208
             R+ D++    L  +  H   +   +  P +  LL++S DG + +++++     +  + 
Sbjct: 524 LERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKG 583

Query: 209 QSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCM-VPVTESLL 267
            +  +       +G     G  +    L+  + +      FA     ++C       + +
Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRI-FAGHLADVNCTRFHPNSNYV 642

Query: 268 CTGSTDGVIRAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFWDM 324
            TGS D  +R  ++L    V     H G P+  L  S  GRFLA+   D R+  WD+
Sbjct: 643 ATGSADRTVRLWDVLNGNCVRIFTGHKG-PIHSLTFSPNGRFLATGATDGRVLLWDI 698


>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
           [Homo sapiens]
          Length = 340

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 57/246 (23%), Positives = 99/246 (40%), Gaps = 19/246 (7%)

Query: 45  AFHPARDLLAAGDVDGDVFVFSYSCQEGE---TKELWSSGHHLKACRAVAFSEDGQKLIT 101
           A+ P+ + +A G +D    +++   +EG    ++EL     +L  CR   F +D Q ++T
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCR---FLDDSQ-IVT 159

Query: 102 VSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPL 161
            S D    + D+E  Q     +   G  ++  L  D     +G      +LWD R     
Sbjct: 160 SSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCR 219

Query: 162 MDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQS--GDLTSVTLM 219
                H   I  ++  P      T S D    +F+++  +  LL    +    +TSV   
Sbjct: 220 QSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFS 279

Query: 220 KWGKKVACGSSEGTIYLFNWNGFGA-TSDRFALRA---ESIDCMVPVTESL-LCTGSTDG 274
           K G+ +  G  +     FN N +     DR  + A     + C+    + + + TGS D 
Sbjct: 280 KSGRLLLAGYDD-----FNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334

Query: 275 VIRAVN 280
            +R  N
Sbjct: 335 FLRIWN 340


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,653,735
Number of Sequences: 37866
Number of extensions: 720302
Number of successful extensions: 3544
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 99
Number of HSP's successfully gapped in prelim test: 153
Number of HSP's that attempted gapping in prelim test: 2721
Number of HSP's gapped (non-prelim): 768
length of query: 383
length of database: 18,247,518
effective HSP length: 104
effective length of query: 279
effective length of database: 14,309,454
effective search space: 3992337666
effective search space used: 3992337666
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.