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Search of human proteins with 38257139
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38257139 protein kinase, cAMP-dependent, regulatory, type I,
beta [Homo sapiens]
(381 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38257139 protein kinase, cAMP-dependent, regulatory, type I, ... 762 0.0
gi|47132583 cAMP-dependent protein kinase, regulatory subunit al... 630 0.0
gi|47132581 cAMP-dependent protein kinase, regulatory subunit al... 630 0.0
gi|4506063 cAMP-dependent protein kinase, regulatory subunit alp... 630 0.0
gi|47132585 cAMP-dependent protein kinase, regulatory subunit be... 249 4e-66
gi|4758958 cAMP-dependent protein kinase, regulatory subunit alp... 233 3e-61
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 171 1e-42
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 166 4e-41
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 148 7e-36
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 59 7e-09
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 59 7e-09
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 59 7e-09
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 59 9e-09
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 59 9e-09
gi|148727335 patatin-like phospholipase domain containing 7 isof... 55 1e-07
gi|148727290 patatin-like phospholipase domain containing 7 isof... 55 1e-07
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 54 3e-07
gi|116256487 patatin-like phospholipase domain containing 6 [Hom... 49 6e-06
gi|27734929 cyclic nucleotide binding domain containing 1 [Homo ... 41 0.002
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 41 0.002
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 40 0.003
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 40 0.003
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 40 0.003
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 40 0.005
gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 40 0.005
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 40 0.005
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 39 0.008
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 39 0.010
gi|18201890 hypothetical protein LOC140894 [Homo sapiens] 38 0.013
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 37 0.030
>gi|38257139 protein kinase, cAMP-dependent, regulatory, type I,
beta [Homo sapiens]
Length = 381
Score = 762 bits (1967), Expect = 0.0
Identities = 381/381 (100%), Positives = 381/381 (100%)
Query: 1 MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKE 60
MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKE
Sbjct: 1 MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKE 60
Query: 61 ENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPK 120
ENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPK
Sbjct: 61 ENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPK 120
Query: 121 DYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG 180
DYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG
Sbjct: 121 DYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG 180
Query: 181 EVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTL 240
EVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTL
Sbjct: 181 EVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTL 240
Query: 241 RKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTA 300
RKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTA
Sbjct: 241 RKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTA 300
Query: 301 SVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLG 360
SVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLG
Sbjct: 301 SVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLG 360
Query: 361 PCSEILKRNIQRYNSFISLTV 381
PCSEILKRNIQRYNSFISLTV
Sbjct: 361 PCSEILKRNIQRYNSFISLTV 381
>gi|47132583 cAMP-dependent protein kinase, regulatory subunit alpha
1 [Homo sapiens]
Length = 381
Score = 630 bits (1625), Expect = 0.0
Identities = 310/381 (81%), Positives = 345/381 (90%)
Query: 1 MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKE 60
M S SEE SL+ CELYVQ H IQ +LKD IV LC ++PERPM FLRE+FE+LEKE
Sbjct: 1 MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60
Query: 61 ENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPK 120
E +QI QK+ +++DS ++E+SP PPNPVVK RRRRG +SAEVYTEEDA SYVRKVIPK
Sbjct: 61 EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120
Query: 121 DYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG 180
DYKTM ALAKAI KNVLF+HLDDNERSDIFDAMF V+ IAGETVIQQG+EGDNFYV+DQG
Sbjct: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180
Query: 181 EVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTL 240
E DVYVN EW T++ EGGSFGELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTL
Sbjct: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240
Query: 241 RKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTA 300
RKRKMYEEFLSKVSILESL+KWERLTVADALEPVQFEDG+KIVVQGEPGD+F+II EG+A
Sbjct: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300
Query: 301 SVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLG 360
+VLQRRS NEE+VEVGRLGPSDYFGEIALL+NRPRAATVVARGPLKCVKLDRPRFERVLG
Sbjct: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360
Query: 361 PCSEILKRNIQRYNSFISLTV 381
PCS+ILKRNIQ+YNSF+SL+V
Sbjct: 361 PCSDILKRNIQQYNSFVSLSV 381
>gi|47132581 cAMP-dependent protein kinase, regulatory subunit alpha
1 [Homo sapiens]
Length = 381
Score = 630 bits (1625), Expect = 0.0
Identities = 310/381 (81%), Positives = 345/381 (90%)
Query: 1 MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKE 60
M S SEE SL+ CELYVQ H IQ +LKD IV LC ++PERPM FLRE+FE+LEKE
Sbjct: 1 MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60
Query: 61 ENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPK 120
E +QI QK+ +++DS ++E+SP PPNPVVK RRRRG +SAEVYTEEDA SYVRKVIPK
Sbjct: 61 EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120
Query: 121 DYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG 180
DYKTM ALAKAI KNVLF+HLDDNERSDIFDAMF V+ IAGETVIQQG+EGDNFYV+DQG
Sbjct: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180
Query: 181 EVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTL 240
E DVYVN EW T++ EGGSFGELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTL
Sbjct: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240
Query: 241 RKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTA 300
RKRKMYEEFLSKVSILESL+KWERLTVADALEPVQFEDG+KIVVQGEPGD+F+II EG+A
Sbjct: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300
Query: 301 SVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLG 360
+VLQRRS NEE+VEVGRLGPSDYFGEIALL+NRPRAATVVARGPLKCVKLDRPRFERVLG
Sbjct: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360
Query: 361 PCSEILKRNIQRYNSFISLTV 381
PCS+ILKRNIQ+YNSF+SL+V
Sbjct: 361 PCSDILKRNIQQYNSFVSLSV 381
>gi|4506063 cAMP-dependent protein kinase, regulatory subunit alpha
1 [Homo sapiens]
Length = 381
Score = 630 bits (1625), Expect = 0.0
Identities = 310/381 (81%), Positives = 345/381 (90%)
Query: 1 MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKE 60
M S SEE SL+ CELYVQ H IQ +LKD IV LC ++PERPM FLRE+FE+LEKE
Sbjct: 1 MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE 60
Query: 61 ENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPK 120
E +QI QK+ +++DS ++E+SP PPNPVVK RRRRG +SAEVYTEEDA SYVRKVIPK
Sbjct: 61 EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK 120
Query: 121 DYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG 180
DYKTM ALAKAI KNVLF+HLDDNERSDIFDAMF V+ IAGETVIQQG+EGDNFYV+DQG
Sbjct: 121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG 180
Query: 181 EVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTL 240
E DVYVN EW T++ EGGSFGELALIYGTPRAATVKAKT++KLWGIDRDSYRRILMGSTL
Sbjct: 181 ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL 240
Query: 241 RKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTA 300
RKRKMYEEFLSKVSILESL+KWERLTVADALEPVQFEDG+KIVVQGEPGD+F+II EG+A
Sbjct: 241 RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA 300
Query: 301 SVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLG 360
+VLQRRS NEE+VEVGRLGPSDYFGEIALL+NRPRAATVVARGPLKCVKLDRPRFERVLG
Sbjct: 301 AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG 360
Query: 361 PCSEILKRNIQRYNSFISLTV 381
PCS+ILKRNIQ+YNSF+SL+V
Sbjct: 361 PCSDILKRNIQQYNSFVSLSV 381
>gi|47132585 cAMP-dependent protein kinase, regulatory subunit beta
2 [Homo sapiens]
Length = 418
Score = 249 bits (635), Expect = 4e-66
Identities = 151/394 (38%), Positives = 211/394 (53%), Gaps = 48/394 (12%)
Query: 26 GIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILAR----------------- 68
G+ ++L+ V + +P ++F +HF +L++E R+ AR
Sbjct: 8 GLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAAGG 67
Query: 69 ---------QKSNSQSDSHD---EEVSPTPPN----PVVKARRRRGGVSAEVYT----EE 108
+ QSDS D EE +P PV+ RR V AE Y E+
Sbjct: 68 GTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEED 127
Query: 109 DAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQG 168
DA S R + PK L +A +LF +LD + S + DAMF GE VI QG
Sbjct: 128 DAES--RIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQG 185
Query: 169 NEGDNFYVVDQGEVDVYVN----GEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLW 224
++GDNFYV+D+G D+YV G V N GSFGELAL+Y TPRAAT+ A + LW
Sbjct: 186 DDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALW 245
Query: 225 GIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVV 284
G+DR ++RRI++ + +KRKMYE F+ + L+SLE ERL V D + + DGE+I+
Sbjct: 246 GLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIA 305
Query: 285 QGEPGDDFYIITEGTASVLQRRSPNEEY-----VEVGRLGPSDYFGEIALLLNRPRAATV 339
QG+ D F+I+ G + +R E VE+ R YFGE+AL+ N+PRAA+
Sbjct: 306 QGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASA 365
Query: 340 VARGPLKCVKLDRPRFERVLGPCSEILKRNIQRY 373
A G +KC+ +D FER+LGPC EI+KRNI Y
Sbjct: 366 HAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATY 399
>gi|4758958 cAMP-dependent protein kinase, regulatory subunit alpha
2 [Homo sapiens]
Length = 404
Score = 233 bits (593), Expect = 3e-61
Identities = 141/378 (37%), Positives = 209/378 (55%), Gaps = 31/378 (8%)
Query: 26 GIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEEN----------RQILAR------- 68
G+ ++L+ V + +P ++F E+F +L + RQ L
Sbjct: 9 GLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGP 68
Query: 69 -QKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYT--EEDAVSYVRKVIPKDYKTM 125
+ ++++ DS EE PV RR V AE Y EE+ + R + PK +
Sbjct: 69 DRVADAKGDSESEEDEDLEV-PVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQR 127
Query: 126 TALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVY 185
L +A +LF +LD + S + DAMF A E VI QG++GDNFYV+++G D+
Sbjct: 128 CRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDIL 187
Query: 186 VNGEWVTN----ISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLR 241
V + T GSFGELAL+Y TPRAAT+ A ++ LWG+DR ++RRI++ + +
Sbjct: 188 VTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAK 247
Query: 242 KRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTAS 301
KRKM+E F+ V +L+SLE ER+ + D + ++DGE+I+ QGE D FYII G S
Sbjct: 248 KRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVS 307
Query: 302 VLQR------RSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRF 355
+L R + + VE+ R YFGE+AL+ N+PRAA+ A G +KC+ +D F
Sbjct: 308 ILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAF 367
Query: 356 ERVLGPCSEILKRNIQRY 373
ER+LGPC +I+KRNI Y
Sbjct: 368 ERLLGPCMDIMKRNISHY 385
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 171 bits (433), Expect = 1e-42
Identities = 108/311 (34%), Positives = 164/311 (52%), Gaps = 10/311 (3%)
Query: 58 EKEENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEE---DAVSYV 114
EKEE Q L R+ QS V P P + R G+SAE T D
Sbjct: 28 EKEEEIQELKRKLHKCQS------VLPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAF 81
Query: 115 RKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNF 174
RK K ++ + +AI N +L+ ++ +I D M+PV + +I++G+ G
Sbjct: 82 RK-FTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLV 140
Query: 175 YVVDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRI 234
YV++ G+V+V G + + G FGELA++Y R ATVK ++KLW IDR ++ I
Sbjct: 141 YVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTI 200
Query: 235 LMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYI 294
+M + L K Y EFL V +SL + +AD LE +E+GE I+ QG GD F+I
Sbjct: 201 MMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFI 260
Query: 295 ITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPR 354
I++GT +V + SP+E+ V + LG D+FGE AL R A V+A + C+ +DR
Sbjct: 261 ISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDS 320
Query: 355 FERVLGPCSEI 365
F+ ++G ++
Sbjct: 321 FKHLIGGLDDV 331
Score = 50.8 bits (120), Expect = 2e-06
Identities = 37/138 (26%), Positives = 62/138 (44%), Gaps = 6/138 (4%)
Query: 138 FAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGE------WV 191
F L + S + D + + GE +I+QG GD F+++ +G V+V ++
Sbjct: 222 FQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFL 281
Query: 192 TNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLS 251
+ +G FGE AL R A V A + IDRDS++ ++ G K YE+ +
Sbjct: 282 RTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEA 341
Query: 252 KVSILESLEKWERLTVAD 269
K + L ++D
Sbjct: 342 KAKYEAEAAFFANLKLSD 359
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 166 bits (419), Expect = 4e-41
Identities = 101/321 (31%), Positives = 169/321 (52%), Gaps = 10/321 (3%)
Query: 55 EKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPVVKA--------RRRRGGVSAE--V 104
++LE E +++ QK ++ D + + P ++ R +R +SAE
Sbjct: 26 DELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSASTLQGEPRTKRQAISAEPTA 85
Query: 105 YTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETV 164
+ +D PK ++ + +AI N +L+ ++ +I D M+PV + +
Sbjct: 86 FDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCI 145
Query: 165 IQQGNEGDNFYVVDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLW 224
I++G+ G YV++ G+V+V G + + G FGELA++Y R ATVK ++KLW
Sbjct: 146 IKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLW 205
Query: 225 GIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVV 284
IDR ++ I+M + L K Y EFL V +SL + +AD LE +E+GE I+
Sbjct: 206 AIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIR 265
Query: 285 QGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGP 344
QG GD F+II++GT +V + SP+E+ V + LG D+FGE AL R A V+A
Sbjct: 266 QGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEA 325
Query: 345 LKCVKLDRPRFERVLGPCSEI 365
+ C+ +DR F+ ++G ++
Sbjct: 326 VTCLVIDRDSFKHLIGGLDDV 346
Score = 50.8 bits (120), Expect = 2e-06
Identities = 37/138 (26%), Positives = 62/138 (44%), Gaps = 6/138 (4%)
Query: 138 FAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGE------WV 191
F L + S + D + + GE +I+QG GD F+++ +G V+V ++
Sbjct: 237 FQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFL 296
Query: 192 TNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLS 251
+ +G FGE AL R A V A + IDRDS++ ++ G K YE+ +
Sbjct: 297 RTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEA 356
Query: 252 KVSILESLEKWERLTVAD 269
K + L ++D
Sbjct: 357 KAKYEAEAAFFANLKLSD 374
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 148 bits (374), Expect = 7e-36
Identities = 99/356 (27%), Positives = 175/356 (49%), Gaps = 28/356 (7%)
Query: 40 ISKPERPMKFLREHFEK-----LEKEENRQILARQKSNSQSDSHDEEVSPTPPNP----- 89
I + E +K LRE K E E Q Q + Q H + SP +P
Sbjct: 44 IQEREYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPL 103
Query: 90 --------VVKARRRRG---GVSAEVYT------EEDAVSYVRKVIPKDYKTMTALAKAI 132
+V RRG GVSAE T + S+ + + KD + A+
Sbjct: 104 EVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDAL 163
Query: 133 SKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEWVT 192
+KN LD + D+ + M+ + G +I+QG G++ +V+ +G ++V+ + ++
Sbjct: 164 NKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLS 223
Query: 193 NISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSK 252
+I +FGELA++Y R A+VKA T++K W +DR+ ++ I+ + + + Y FL
Sbjct: 224 SIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRS 283
Query: 253 VSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEY 312
VS+L++L + + + D LE ++ G+ I+ +GE G F+I+ +G V Q +++
Sbjct: 284 VSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQP 343
Query: 313 VEVGRLGPSDYFGEIALLLNRPRAATVVA-RGPLKCVKLDRPRFERVLGPCSEILK 367
+ L +YFGE AL+ + R+A ++A + C+ +DR F + +G E+ K
Sbjct: 344 QLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQK 399
Score = 51.6 bits (122), Expect = 1e-06
Identities = 34/150 (22%), Positives = 69/150 (46%), Gaps = 6/150 (4%)
Query: 230 SYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPG 289
S+ + + ++K+ + L+K L+ L+ + + + + ++ G I+ QGEPG
Sbjct: 143 SFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPG 202
Query: 290 DDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVK 349
+ +++ EG V Q + + FGE+A+L N R A+V A +K
Sbjct: 203 NHIFVLAEGRLEVFQGEKL------LSSIPMWTTFGELAILYNCTRTASVKAITNVKTWA 256
Query: 350 LDRPRFERVLGPCSEILKRNIQRYNSFISL 379
LDR F+ ++ ++ + + +SL
Sbjct: 257 LDREVFQNIMRRTAQARDEQYRNFLRSVSL 286
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 58.9 bits (141), Expect = 7e-09
Identities = 37/122 (30%), Positives = 67/122 (54%), Gaps = 4/122 (3%)
Query: 139 AHLDDNERSDIFDAMFPVTHI-AGETVIQQGNEGDNFYVVDQGEVDVYVNGEW-VTNISE 196
AHL ++ + ++ + H AG + QG++G ++Y++ +G V+V +G+ VT + E
Sbjct: 205 AHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHE 264
Query: 197 GGSFGELALIYGTPRAATVKAKTD-LKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 255
G FG+LAL+ PRAAT+ + D +D+ + RI+ + ++ EE V +
Sbjct: 265 GDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRL-EEHGKVVLV 323
Query: 256 LE 257
LE
Sbjct: 324 LE 325
Score = 41.6 bits (96), Expect = 0.001
Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 6/116 (5%)
Query: 245 MYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQ 304
++EE L ++ +R A L + G + QG+ G +YII +G+ +V+
Sbjct: 194 IFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVT 253
Query: 305 RRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
V L D FG++AL+ + PRAAT++ R +++D+ F R++
Sbjct: 254 HGKGL-----VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRII 304
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 58.9 bits (141), Expect = 7e-09
Identities = 37/122 (30%), Positives = 67/122 (54%), Gaps = 4/122 (3%)
Query: 139 AHLDDNERSDIFDAMFPVTHI-AGETVIQQGNEGDNFYVVDQGEVDVYVNGEW-VTNISE 196
AHL ++ + ++ + H AG + QG++G ++Y++ +G V+V +G+ VT + E
Sbjct: 205 AHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHE 264
Query: 197 GGSFGELALIYGTPRAATVKAKTD-LKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 255
G FG+LAL+ PRAAT+ + D +D+ + RI+ + ++ EE V +
Sbjct: 265 GDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRL-EEHGKVVLV 323
Query: 256 LE 257
LE
Sbjct: 324 LE 325
Score = 41.6 bits (96), Expect = 0.001
Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 6/116 (5%)
Query: 245 MYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQ 304
++EE L ++ +R A L + G + QG+ G +YII +G+ +V+
Sbjct: 194 IFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVT 253
Query: 305 RRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
V L D FG++AL+ + PRAAT++ R +++D+ F R++
Sbjct: 254 HGKGL-----VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRII 304
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 58.9 bits (141), Expect = 7e-09
Identities = 37/122 (30%), Positives = 67/122 (54%), Gaps = 4/122 (3%)
Query: 139 AHLDDNERSDIFDAMFPVTHI-AGETVIQQGNEGDNFYVVDQGEVDVYVNGEW-VTNISE 196
AHL ++ + ++ + H AG + QG++G ++Y++ +G V+V +G+ VT + E
Sbjct: 247 AHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHE 306
Query: 197 GGSFGELALIYGTPRAATVKAKTD-LKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSI 255
G FG+LAL+ PRAAT+ + D +D+ + RI+ + ++ EE V +
Sbjct: 307 GDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRL-EEHGKVVLV 365
Query: 256 LE 257
LE
Sbjct: 366 LE 367
Score = 41.6 bits (96), Expect = 0.001
Identities = 31/116 (26%), Positives = 56/116 (48%), Gaps = 6/116 (5%)
Query: 245 MYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQ 304
++EE L ++ +R A L + G + QG+ G +YII +G+ +V+
Sbjct: 236 IFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVT 295
Query: 305 RRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
V L D FG++AL+ + PRAAT++ R +++D+ F R++
Sbjct: 296 HGKGL-----VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRII 346
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 58.5 bits (140), Expect = 9e-09
Identities = 40/143 (27%), Positives = 75/143 (52%), Gaps = 10/143 (6%)
Query: 139 AHLDDNERSDIFDAMFPVTHIAGETVI-QQGNEGDNFYVVDQGEVDVYVNGEWVT-NISE 196
+HL + ++ + +H G TV+ QG EG ++Y++ +G V+V + G+ V + E
Sbjct: 214 SHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHE 273
Query: 197 GGSFGELALIYGTPRAATVKAKTD-LKLWGIDRDSYRRILM---GSTLRKRKMYEEFLSK 252
G FG+LAL+ PRAA++ + D +D++ + RIL +T+R ++ ++ L
Sbjct: 274 GDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVL-- 331
Query: 253 VSILESLEKWERLTVADALEPVQ 275
+LE + R + +P Q
Sbjct: 332 --VLEKVPAGNRASNQGNSQPQQ 352
Score = 38.9 bits (89), Expect = 0.008
Identities = 35/117 (29%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 245 MYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVV-QGEPGDDFYIITEGTASVL 303
+YEE L + L L + +A L G ++ QGE G +YII +G+ +V+
Sbjct: 203 IYEELLH-IKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVV 261
Query: 304 QRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
V L D FG++AL+ + PRAA++V R +++D+ F R+L
Sbjct: 262 IYGKG-----VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 313
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform
a [Homo sapiens]
Length = 1011
Score = 58.5 bits (140), Expect = 9e-09
Identities = 40/143 (27%), Positives = 75/143 (52%), Gaps = 10/143 (6%)
Query: 139 AHLDDNERSDIFDAMFPVTHIAGETVI-QQGNEGDNFYVVDQGEVDVYVNGEWVT-NISE 196
+HL + ++ + +H G TV+ QG EG ++Y++ +G V+V + G+ V + E
Sbjct: 358 SHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHE 417
Query: 197 GGSFGELALIYGTPRAATVKAKTD-LKLWGIDRDSYRRILM---GSTLRKRKMYEEFLSK 252
G FG+LAL+ PRAA++ + D +D++ + RIL +T+R ++ ++ L
Sbjct: 418 GDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVL-- 475
Query: 253 VSILESLEKWERLTVADALEPVQ 275
+LE + R + +P Q
Sbjct: 476 --VLEKVPAGNRASNQGNSQPQQ 496
Score = 38.9 bits (89), Expect = 0.008
Identities = 24/81 (29%), Positives = 45/81 (55%), Gaps = 2/81 (2%)
Query: 277 EDGEKIVVQGEPGDDFYIITEGTASV-LQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPR 335
E G + QG+ G ++Y + G+ V + S +++ V + LG FGE ++L N PR
Sbjct: 65 EKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPR 123
Query: 336 AATVVARGPLKCVKLDRPRFE 356
AT+V R + +++++ F+
Sbjct: 124 HATIVTRESSELLRIEQKDFK 144
Score = 38.9 bits (89), Expect = 0.008
Identities = 35/117 (29%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 245 MYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVV-QGEPGDDFYIITEGTASVL 303
+YEE L + L L + +A L G ++ QGE G +YII +G+ +V+
Sbjct: 347 IYEELLH-IKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVV 405
Query: 304 QRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVAR-GPLKCVKLDRPRFERVL 359
V L D FG++AL+ + PRAA++V R +++D+ F R+L
Sbjct: 406 IYGKG-----VVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL 457
Score = 37.4 bits (85), Expect = 0.023
Identities = 23/81 (28%), Positives = 43/81 (53%), Gaps = 8/81 (9%)
Query: 161 GETVIQQGNEGDNFYVVDQGEVDVYV-------NGEWVTNISEGGSFGELALIYGTPRAA 213
G T+ +QG+ G N+Y V G +DV V + + + G +FGE +++ TPR A
Sbjct: 67 GITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHA 125
Query: 214 TVKAKTDLKLWGIDRDSYRRI 234
T+ + +L I++ ++ +
Sbjct: 126 TIVTRESSELLRIEQKDFKAL 146
>gi|148727335 patatin-like phospholipase domain containing 7 isoform
a [Homo sapiens]
Length = 1342
Score = 54.7 bits (130), Expect = 1e-07
Identities = 67/274 (24%), Positives = 120/274 (43%), Gaps = 23/274 (8%)
Query: 87 PNPVVKARRRRGGVSAEVYT--EEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDN 144
P V ++ R+ + AE+ + + + S+ + + + A+ +A K++L L
Sbjct: 435 PGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLAS--RKSDAIFRAAKKDLLT--LMKL 490
Query: 145 ERSDIFDAMFPVTHI-AGETVIQQGNEGDNFYVVDQGEVDVY---VNGEWVTNI---SEG 197
E S + D + H+ AG V +QG++ + V G + VY + + T + G
Sbjct: 491 EDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPG 550
Query: 198 GSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKV-SIL 256
G+LA++ G P TVKA D I + + I+ RK L +++
Sbjct: 551 EMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIM-------RKQPTVVLGVAHTVV 603
Query: 257 ESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVG 316
+ + + R + AL+ V+ E G I QG+ D YI+ G + R+ ++ + G
Sbjct: 604 KRMSSFVR-QIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRL-AG 661
Query: 317 RLGPSDYFGEIALLLNRPRAATVVARGPLKCVKL 350
G D G + L ++ RA TV A + KL
Sbjct: 662 EYGRGDLVGVVETLTHQARATTVHAVRDSELAKL 695
Score = 32.0 bits (71), Expect = 0.95
Identities = 27/122 (22%), Positives = 49/122 (40%), Gaps = 1/122 (0%)
Query: 239 TLRKRKMYEEFLSKVSILESLEKWERLTVADA-LEPVQFEDGEKIVVQGEPGDDFYIITE 297
TL RK F + L +L K E ++ D + + G + QG+ +
Sbjct: 467 TLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVS 526
Query: 298 GTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFER 357
G V QR+ ++E + P + G++A+L P TV A + + + F
Sbjct: 527 GLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYE 586
Query: 358 VL 359
++
Sbjct: 587 IM 588
>gi|148727290 patatin-like phospholipase domain containing 7 isoform
b [Homo sapiens]
Length = 1317
Score = 54.7 bits (130), Expect = 1e-07
Identities = 67/274 (24%), Positives = 120/274 (43%), Gaps = 23/274 (8%)
Query: 87 PNPVVKARRRRGGVSAEVYT--EEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDN 144
P V ++ R+ + AE+ + + + S+ + + + A+ +A K++L L
Sbjct: 410 PGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLAS--RKSDAIFRAAKKDLLT--LMKL 465
Query: 145 ERSDIFDAMFPVTHI-AGETVIQQGNEGDNFYVVDQGEVDVY---VNGEWVTNI---SEG 197
E S + D + H+ AG V +QG++ + V G + VY + + T + G
Sbjct: 466 EDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPG 525
Query: 198 GSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKV-SIL 256
G+LA++ G P TVKA D I + + I+ RK L +++
Sbjct: 526 EMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIM-------RKQPTVVLGVAHTVV 578
Query: 257 ESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVG 316
+ + + R + AL+ V+ E G I QG+ D YI+ G + R+ ++ + G
Sbjct: 579 KRMSSFVR-QIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRL-AG 636
Query: 317 RLGPSDYFGEIALLLNRPRAATVVARGPLKCVKL 350
G D G + L ++ RA TV A + KL
Sbjct: 637 EYGRGDLVGVVETLTHQARATTVHAVRDSELAKL 670
Score = 32.0 bits (71), Expect = 0.95
Identities = 27/122 (22%), Positives = 49/122 (40%), Gaps = 1/122 (0%)
Query: 239 TLRKRKMYEEFLSKVSILESLEKWERLTVADA-LEPVQFEDGEKIVVQGEPGDDFYIITE 297
TL RK F + L +L K E ++ D + + G + QG+ +
Sbjct: 442 TLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVS 501
Query: 298 GTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFER 357
G V QR+ ++E + P + G++A+L P TV A + + + F
Sbjct: 502 GLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYE 561
Query: 358 VL 359
++
Sbjct: 562 IM 563
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 53.5 bits (127), Expect = 3e-07
Identities = 30/114 (26%), Positives = 55/114 (48%)
Query: 130 KAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGE 189
K ++ LFA+ D N + + + G+ +I++G G Y + G V V G
Sbjct: 537 KLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGN 596
Query: 190 WVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKR 243
+S+G FGE+ L+ R A+V+A T +L+ + D++ +L + +R
Sbjct: 597 KEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 650
Score = 40.0 bits (92), Expect = 0.003
Identities = 29/84 (34%), Positives = 38/84 (45%), Gaps = 6/84 (7%)
Query: 276 FEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPR 335
F+ G+ I+ +G G Y I G SVL + N+E +L YFGEI LL R
Sbjct: 565 FQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKEM----KLSDGSYFGEICLLTRGRR 618
Query: 336 AATVVARGPLKCVKLDRPRFERVL 359
A+V A + L F VL
Sbjct: 619 TASVRADTYCRLYSLSVDNFNEVL 642
>gi|116256487 patatin-like phospholipase domain containing 6 [Homo
sapiens]
Length = 1327
Score = 49.3 bits (116), Expect = 6e-06
Identities = 63/285 (22%), Positives = 114/285 (40%), Gaps = 19/285 (6%)
Query: 74 QSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAIS 133
Q ++ ++ P + R + G Y E+++ + P + +++ +A
Sbjct: 402 QEEASGGSLAAPARTPTQEPREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAK 461
Query: 134 KNVLFAHLDDNERSDIFDAMFPVTHI-AGETVIQQGNEGDNFYVVDQGEVDVY------V 186
+ + A L E + ++ + H AG + +QG++ + + V G + VY
Sbjct: 462 QEL--AKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKA 519
Query: 187 NGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMY 246
+ G G+LA++ G P T++A+ D I + + I+ R
Sbjct: 520 EDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSDFYEIM-------RAQP 572
Query: 247 EEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEG-TASVLQR 305
LS + + + A++ E G + QG+ D YI+ G SV+QR
Sbjct: 573 SVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQR 632
Query: 306 RSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKL 350
S +E VG G D G + L +PRA TV A + KL
Sbjct: 633 GSGKKEL--VGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKL 675
>gi|27734929 cyclic nucleotide binding domain containing 1 [Homo
sapiens]
Length = 436
Score = 41.2 bits (95), Expect = 0.002
Identities = 75/367 (20%), Positives = 142/367 (38%), Gaps = 87/367 (23%)
Query: 46 PMKFLRE--HFEKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGG---V 100
P FL + KL K+E ++ L K SQ D+ N V +R GG
Sbjct: 71 PKVFLHQKPRLPKLFKQEEQRELNEGKEESQHQQPDDS-----NNIAVHVQRAHGGHILY 125
Query: 101 SAEVYTE--EDAVSYVRKV----IPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMF 154
+ TE E+ ++ ++K+ P ++KT+ K I L L+D + +F
Sbjct: 126 RPKRATEKFEEFLAILKKLPIHRTPYEHKTVWKFLKTIPD--LTFQLNDKHLKTLSKTVF 183
Query: 155 PVTHIAGETVIQQGNEGDNFYVVDQG----EVDVYVN----------------------- 187
T + G TV+ D FYV+ +G + +VY N
Sbjct: 184 SETWLKGSTVVAN----DGFYVILKGLARPQTNVYKNLIEGSDSPDSFISQSFHSFIWSE 239
Query: 188 ------------GEWVTNISEGGSFGELALI---YGTPRAATVKAKTDLKLWGIDRDSYR 232
+ + +S+ +FG L ++ + +V + D ++ I Y
Sbjct: 240 EFKNSTLAEMYLPSYDSMLSKWSTFGTLEVMPQNESETQMFSVVTEDDCEILKIPAKGYA 299
Query: 233 RILMGSTLRKRKMYEEFLSKVSILESL---EKWERLTVADALEPVQ---FEDGEKIVVQG 286
+I ++ K+ E + K+ ++ E+W L++ + + ++ F G IV G
Sbjct: 300 KI------KEEKIKLENMQKLKLIRMCPYYEEWPTLSIYELIALLKWKKFPPGHVIVESG 353
Query: 287 EPGDDFYIITEGTASVLQ-----------RRSPNEEYVEVGRLGPSDYFGEIALLLNRPR 335
I G ++ + + +++ V +G+L + FGEI++LL P
Sbjct: 354 NIISFVGYINSGCCNIYRSIIGFVKLRSNKVKRSQKLVYMGKLKEKESFGEISVLLQVPF 413
Query: 336 AATVVAR 342
T++ +
Sbjct: 414 TCTIITK 420
>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
Length = 809
Score = 40.8 bits (94), Expect = 0.002
Identities = 31/111 (27%), Positives = 51/111 (45%), Gaps = 6/111 (5%)
Query: 132 ISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEW- 190
ISK LF D D+ + V ++ G+ V ++G G Y++ GEV V +
Sbjct: 519 ISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGT 578
Query: 191 --VTNISEGGSFGELALIY---GTPRAATVKAKTDLKLWGIDRDSYRRILM 236
+ + G FGE++L+ G R A V A L +D+ + + IL+
Sbjct: 579 KVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILV 629
Score = 39.3 bits (90), Expect = 0.006
Identities = 34/113 (30%), Positives = 51/113 (45%), Gaps = 6/113 (5%)
Query: 250 LSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPN 309
+SKV + + + + L+ V + G+ + +GE G + YII G VL P+
Sbjct: 519 ISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVL--GGPD 576
Query: 310 EEYVEVGRLGPSDYFGEIALLL---NRPRAATVVARGPLKCVKLDRPRFERVL 359
V V L FGEI+LL R A VVA G + LD+ + +L
Sbjct: 577 GTKVLV-TLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEIL 628
>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
Length = 774
Score = 40.4 bits (93), Expect = 0.003
Identities = 29/84 (34%), Positives = 37/84 (44%), Gaps = 6/84 (7%)
Query: 276 FEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPR 335
F+ G+ +V +G G Y I G SVL R + + RL YFGEI LL R
Sbjct: 449 FQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDT------RLTDGSYFGEICLLTRGRR 502
Query: 336 AATVVARGPLKCVKLDRPRFERVL 359
A+V A + L F VL
Sbjct: 503 TASVRADTYCRLYSLSVDHFNAVL 526
>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
[Homo sapiens]
Length = 676
Score = 40.0 bits (92), Expect = 0.003
Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
Query: 250 LSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPN 309
L KV I + E + + L P F G+ I +G+ G + YII EG +V+
Sbjct: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 518
Query: 310 EEYVEVGRLGPSDYFGEIALL 330
+ V L YFGEI++L
Sbjct: 519 QFVV----LSDGSYFGEISIL 535
>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
sapiens]
Length = 694
Score = 40.0 bits (92), Expect = 0.003
Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
Query: 250 LSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPN 309
L KV I + E + + L P F G+ I +G+ G + YII EG +V+
Sbjct: 477 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 536
Query: 310 EEYVEVGRLGPSDYFGEIALL 330
+ V L YFGEI++L
Sbjct: 537 QFVV----LSDGSYFGEISIL 553
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 39.7 bits (91), Expect = 0.005
Identities = 27/84 (32%), Positives = 36/84 (42%), Gaps = 6/84 (7%)
Query: 276 FEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPR 335
F+ G+ I+ +G G Y I G SVL + + +L YFGEI LL R
Sbjct: 616 FQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKET------KLADGSYFGEICLLTRGRR 669
Query: 336 AATVVARGPLKCVKLDRPRFERVL 359
A+V A + L F VL
Sbjct: 670 TASVRADTYCRLYSLSVDNFNEVL 693
>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
potassium channel 1 [Homo sapiens]
Length = 890
Score = 39.7 bits (91), Expect = 0.005
Identities = 27/84 (32%), Positives = 36/84 (42%), Gaps = 6/84 (7%)
Query: 276 FEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPR 335
F+ G+ I+ +G G Y I G A V+ + S +L YFGEI LL R
Sbjct: 496 FQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEM------KLTDGSYFGEICLLTKGRR 549
Query: 336 AATVVARGPLKCVKLDRPRFERVL 359
A+V A + L F VL
Sbjct: 550 TASVRADTYCRLYSLSVDNFNEVL 573
>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
Length = 575
Score = 39.7 bits (91), Expect = 0.005
Identities = 24/81 (29%), Positives = 42/81 (51%), Gaps = 4/81 (4%)
Query: 250 LSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPN 309
LS+V I ++ E + L+P + GE + +G+ G + YII EG +V+ +
Sbjct: 343 LSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVV----AD 398
Query: 310 EEYVEVGRLGPSDYFGEIALL 330
+ + LG YFGEI+++
Sbjct: 399 DGITQYAVLGAGLYFGEISII 419
>gi|54633319 PDZ domain-containing guanine nucleotide exchange
factor I [Homo sapiens]
Length = 1601
Score = 38.9 bits (89), Expect = 0.008
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 2/113 (1%)
Query: 138 FAHLDDNERSDIFDAM-FPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEWVTNISE 196
FA++ + R ++ M F V AG +++ G E D++YV+ G V++ V N+
Sbjct: 281 FANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFM 340
Query: 197 GGSFGELALIYGTPRAATVKAKT-DLKLWGIDRDSYRRILMGSTLRKRKMYEE 248
G SFG + V+ K D + I + Y RIL K+ EE
Sbjct: 341 GNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEE 393
>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
sapiens]
Length = 1251
Score = 38.5 bits (88), Expect = 0.010
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 6/111 (5%)
Query: 132 ISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEW- 190
+SK LF D D+ + V ++ + V ++G G Y++ G+V V +
Sbjct: 957 VSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGK 1016
Query: 191 --VTNISEGGSFGELALIY---GTPRAATVKAKTDLKLWGIDRDSYRRILM 236
+ + G FGE++L+ G R A V A L+ +D+ IL+
Sbjct: 1017 SVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILV 1067
Score = 37.4 bits (85), Expect = 0.023
Identities = 33/113 (29%), Positives = 50/113 (44%), Gaps = 6/113 (5%)
Query: 250 LSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPN 309
+SKV++ + ++ + L V + + + +GE G + YII G VL P+
Sbjct: 957 VSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVL--GGPD 1014
Query: 310 EEYVEVGRLGPSDYFGEIALLL---NRPRAATVVARGPLKCVKLDRPRFERVL 359
+ V V L FGEI+LL R A VVA G LD+ +L
Sbjct: 1015 GKSVLV-TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEIL 1066
>gi|18201890 hypothetical protein LOC140894 [Homo sapiens]
Length = 572
Score = 38.1 bits (87), Expect = 0.013
Identities = 32/152 (21%), Positives = 70/152 (46%), Gaps = 13/152 (8%)
Query: 164 VIQQGNEGDNFYVVDQGEVDVYVNGEWVTN--------ISEGGSFGELALIYGTPRAATV 215
+I++G +G++FY + G V + + + + + +G FGE+ +++ + R +T+
Sbjct: 143 IIKKGQKGNSFYFIYLGTVAITKDEDGSSAFLDPHPKLLHKGSCFGEMDVLHASVRRSTI 202
Query: 216 KAKTDLKLWGIDRDSYRRILMGSTLRKRKMYE-EFLSKVSILESL--EKWERLTVADALE 272
+ + +DR+ + + ++K Y EF K+ + S EK +L +E
Sbjct: 203 VCMEETEFLVVDREDFFANKLDQEVQKDAQYRFEFFRKMELFASWSDEKLWQLVAMAKIE 262
Query: 273 PVQFEDGEKIVVQGEPGDDFYIITEGTASVLQ 304
+F G+ I I++G+ VL+
Sbjct: 263 --RFSYGQLISKDFGESPFIMFISKGSCEVLR 292
Score = 32.7 bits (73), Expect = 0.56
Identities = 26/117 (22%), Positives = 54/117 (46%), Gaps = 8/117 (6%)
Query: 247 EEFLSKVSILESLEKWE------RLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTA 300
+E + +IL+ L+ + +L +A + +F I+ +G+ G+ FY I GT
Sbjct: 102 DEIQAVCNILQVLDSYRNYAEPLQLLLAKVMRFERFGRRRVIIKKGQKGNSFYFIYLGTV 161
Query: 301 SVLQRRSPNEEYVE--VGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRF 355
++ + + +++ L FGE+ +L R +T+V + + +DR F
Sbjct: 162 AITKDEDGSSAFLDPHPKLLHKGSCFGEMDVLHASVRRSTIVCMEETEFLVVDREDF 218
>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
[Homo sapiens]
Length = 759
Score = 37.0 bits (84), Expect = 0.030
Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
Query: 250 LSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPN 309
L KV I E + + L+P + G+ I +G+ G + YII EG +V+
Sbjct: 543 LKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVT 602
Query: 310 EEYVEVGRLGPSDYFGEIALL 330
+ V L YFGEI++L
Sbjct: 603 QFVV----LSDGSYFGEISIL 619
Score = 32.7 bits (73), Expect = 0.56
Identities = 29/134 (21%), Positives = 61/134 (45%), Gaps = 13/134 (9%)
Query: 114 VRKVIPKDYKTMTAL---AKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNE 170
V K +P + A+ + K +FA + ++ + P + G+ + ++G+
Sbjct: 522 VLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDI 581
Query: 171 GDNFYVVDQGEVDVYVNGEWVTN---ISEGGSFGELALI------YGTPRAATVKAKTDL 221
G Y++ +G++ V V + VT +S+G FGE++++ G R A +K+
Sbjct: 582 GREMYIIKEGKLAV-VADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYS 640
Query: 222 KLWGIDRDSYRRIL 235
L+ + +D L
Sbjct: 641 DLFCLSKDDLMEAL 654
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,970,095
Number of Sequences: 37866
Number of extensions: 677521
Number of successful extensions: 2554
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 2439
Number of HSP's gapped (non-prelim): 95
length of query: 381
length of database: 18,247,518
effective HSP length: 104
effective length of query: 277
effective length of database: 14,309,454
effective search space: 3963718758
effective search space used: 3963718758
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.