Search of human proteins with 37620181

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
         (1049 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]           2140   0.0  
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]           2133   0.0  
gi|7657152 hect domain and RLD 3 [Homo sapiens]                      1176   0.0  
gi|61563742 hect domain and RLD 6 [Homo sapiens]                      649   0.0  
gi|110825982 hect domain and RLD 5 [Homo sapiens]                     634   0.0  
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]        306   5e-83
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]     301   2e-81
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]     301   2e-81
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]     301   2e-81
gi|126032348 hect domain and RLD 2 [Homo sapiens]                     188   3e-47
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote...   180   7e-45
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i...   179   1e-44
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i...   179   1e-44
gi|222352183 neural precursor cell expressed, developmentally do...   177   6e-44
gi|21361472 neural precursor cell expressed, developmentally dow...   177   6e-44
gi|222352094 neural precursor cell expressed, developmentally do...   177   6e-44
gi|222352092 neural precursor cell expressed, developmentally do...   177   6e-44
gi|222352090 neural precursor cell expressed, developmentally do...   177   6e-44
gi|222352088 neural precursor cell expressed, developmentally do...   177   6e-44
gi|222352086 neural precursor cell expressed, developmentally do...   177   6e-44
gi|222352084 neural precursor cell expressed, developmentally do...   177   6e-44
gi|222352082 neural precursor cell expressed, developmentally do...   177   6e-44
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa...   176   8e-44
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]      176   8e-44
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H...   176   1e-43
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H...   176   1e-43
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi...   172   1e-42
gi|114520609 neural precursor cell expressed, developmentally do...   170   6e-42
gi|114520607 neural precursor cell expressed, developmentally do...   170   6e-42
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]   170   7e-42

>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
          Length = 1049

 Score = 2140 bits (5545), Expect = 0.0
 Identities = 1049/1049 (100%), Positives = 1049/1049 (100%)

Query: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
            MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
            NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120

Query: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180
            SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180

Query: 181  PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240
            PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR
Sbjct: 181  PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 241  SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA 300
            SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA
Sbjct: 241  SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA 300

Query: 301  CGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE 360
            CGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE
Sbjct: 301  CGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE 360

Query: 361  YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPV 420
            YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPV
Sbjct: 361  YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPV 420

Query: 421  EIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQ 480
            EIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQ
Sbjct: 421  EIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQ 480

Query: 481  QVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP 540
            QVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP
Sbjct: 481  QVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP 540

Query: 541  LKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEIL 600
            LKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEIL
Sbjct: 541  LKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEIL 600

Query: 601  HRVNEKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMLADIPVTICTYPFVFDAQ 660
            HRVNEKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMLADIPVTICTYPFVFDAQ
Sbjct: 601  HRVNEKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMLADIPVTICTYPFVFDAQ 660

Query: 661  AKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRK 720
            AKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRK
Sbjct: 661  AKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRK 720

Query: 721  TKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKT 780
            TKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKT
Sbjct: 721  TKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKT 780

Query: 781  FEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQL 840
            FEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQL
Sbjct: 781  FEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQL 840

Query: 841  LDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKS 900
            LDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKS
Sbjct: 841  LDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKS 900

Query: 901  VASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPT 960
            VASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPT
Sbjct: 901  VASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPT 960

Query: 961  IKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNL 1020
            IKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNL
Sbjct: 961  IKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNL 1020

Query: 1021 LDLPKYTEKETLRSKLIQAIDHNEGFSLI 1049
            LDLPKYTEKETLRSKLIQAIDHNEGFSLI
Sbjct: 1021 LDLPKYTEKETLRSKLIQAIDHNEGFSLI 1049


>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
          Length = 1057

 Score = 2133 bits (5526), Expect = 0.0
 Identities = 1049/1057 (99%), Positives = 1049/1057 (99%), Gaps = 8/1057 (0%)

Query: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
            MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC
Sbjct: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
            NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG
Sbjct: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120

Query: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180
            SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
Sbjct: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180

Query: 181  PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240
            PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR
Sbjct: 181  PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240

Query: 241  SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA 300
            SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA
Sbjct: 241  SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA 300

Query: 301  CGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE 360
            CGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE
Sbjct: 301  CGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE 360

Query: 361  YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPV 420
            YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPV
Sbjct: 361  YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPV 420

Query: 421  EIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQ 480
            EIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQ
Sbjct: 421  EIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQ 480

Query: 481  QVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP 540
            QVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP
Sbjct: 481  QVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP 540

Query: 541  LKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEIL 600
            LKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEIL
Sbjct: 541  LKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEIL 600

Query: 601  HRVNEKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGM--------LADIPVTICT 652
            HRVNEKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGM        LADIPVTICT
Sbjct: 601  HRVNEKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMDVNHGLTELADIPVTICT 660

Query: 653  YPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVG 712
            YPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVG
Sbjct: 661  YPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVG 720

Query: 713  DAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSR 772
            DAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSR
Sbjct: 721  DAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSR 780

Query: 773  LIWFSDKTFEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPD 832
            LIWFSDKTFEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPD
Sbjct: 781  LIWFSDKTFEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPD 840

Query: 833  VGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAY 892
            VGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAY
Sbjct: 841  VGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAY 900

Query: 893  VDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKG 952
            VDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKG
Sbjct: 901  VDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKG 960

Query: 953  EYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLP 1012
            EYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLP
Sbjct: 961  EYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLP 1020

Query: 1013 VSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSLI 1049
            VSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSLI
Sbjct: 1021 VSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSLI 1057


>gi|7657152 hect domain and RLD 3 [Homo sapiens]
          Length = 1050

 Score = 1176 bits (3041), Expect = 0.0
 Identities = 592/1054 (56%), Positives = 758/1054 (71%), Gaps = 11/1054 (1%)

Query: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
            MLCWG  S GQ G+    + IV EP+   F  ++ V++V CG  H+VF+L+DG VYTCG 
Sbjct: 1    MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60

Query: 61   NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
            N  GQLGHE+   KPEQ+ AL  Q+I+ V+CGE+H+LAL+D+GQ+++WG  SDGQLGL+ 
Sbjct: 61   NTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120

Query: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180
            +E+ + VPR I+ L+   I+QV+CG +H LAL+   + F WG+N +GQLGLG +   Q S
Sbjct: 121  TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 180

Query: 181  PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240
            PQ ++SL GIP  QVAAGGAHSF L+LSGA+FGWG N  GQLGL+DE DR  P  +K LR
Sbjct: 181  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240

Query: 241  SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA 300
            +QK+VYI CGE+HTA LTK GGVFTFGAG  GQLGH+S + E+NPR+V ELMGS VT+IA
Sbjct: 241  TQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIA 300

Query: 301  CGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE 360
            CGRQHT AFVPSSG IY+FG G  GQLGTG T N K P  VKG W  ++GQ     D  +
Sbjct: 301  CGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFK 360

Query: 361  YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPV 420
            Y  VK+IFSGGDQ+F   S  +N  P  DFR  N       +N+  I  W    S     
Sbjct: 361  YHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLSEHNNA 420

Query: 421  EIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQ 480
               N +    SS+ C NGSFL    D+H++T  +  G+D+N+ R+LF KL+   H  I +
Sbjct: 421  NTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILE 480

Query: 481  QVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP 540
            Q+  S E  LIP+L+SS PDVEA+R YL LPE PL+ DS  + T+ IP   A++ L+  P
Sbjct: 481  QILNSFESCLIPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNP 540

Query: 541  LKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEIL 600
             KVL+NWWS + P  F+K+V L+K  V++LL+  K  + P    +FN+++  ALK+LE L
Sbjct: 541  SKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPV---LFNNYITAALKLLEKL 597

Query: 601  HRVNEKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMLA-----DIPVTICTYPF 655
            ++VN K+ + ++YD FYI E+  L+DI+ DY+ W   QA GM A        VT+C+YPF
Sbjct: 598  YKVNLKV-KHVEYDTFYIPEISNLVDIQEDYLMWFLHQA-GMKARPSIIQDTVTLCSYPF 655

Query: 656  VFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLF-LPVIESVNPCLILVVRRENIVGDA 714
            +FDAQAKT +LQTDA LQMQ+A++ A+ QNV  L  L  + + +P L+L VRR N+VGDA
Sbjct: 656  IFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDA 715

Query: 715  MEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLI 774
            +  L    +ID KKPLKVIF GE+AVDAGGV KEFFLL+++ELL+P YGMF YY+DS L+
Sbjct: 716  LRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLL 775

Query: 775  WFSDKTFEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVG 834
            WFSD  F + + FHLIG+ CGLAIYN T+VDLHFPLALYKKLL  KP L+DLKEL P  G
Sbjct: 776  WFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEG 835

Query: 835  RSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVD 894
            RS+Q+LLDYP +D+EETFCLNFTI  E++G  E K+L+  G +  V K NRQEFVDAYV+
Sbjct: 836  RSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVN 895

Query: 895  YIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEY 954
            Y+F  SV   + AF +GF KVCGGKVL LFQP+EL+AM++GN+NY+W+ELE+   YKG+Y
Sbjct: 896  YVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDY 955

Query: 955  WAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVS 1014
             A HPT+K+FWE FHE PLEKKK+FLLFLTGSDRIPI GM SL++VIQST  GEEYLPV+
Sbjct: 956  SATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVA 1015

Query: 1015 HTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1048
            HTC+NLLDLPKY+ KE L ++L QA+D+ EGFSL
Sbjct: 1016 HTCYNLLDLPKYSSKEILSARLTQALDNYEGFSL 1049


>gi|61563742 hect domain and RLD 6 [Homo sapiens]
          Length = 1022

 Score =  649 bits (1675), Expect = 0.0
 Identities = 381/1018 (37%), Positives = 589/1018 (57%), Gaps = 47/1018 (4%)

Query: 42   GLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKK--PEQVVALDAQNIVAVSCGEAHTLAL 99
            G RH++ +L +  V +CG N  GQLG   +++   PE + AL+   +  VSCG+ H+LA+
Sbjct: 31   GERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAV 90

Query: 100  NDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVF 159
              KG+V+AWG  S+GQLG+   +E    P+ I +L+DI+I+QV+CG+YHSLALSK S+VF
Sbjct: 91   CHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVF 150

Query: 160  CWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKF 219
             WG+N +GQLGLG +   Q SPQ ++SL GIP  QVAAGGAHSF L+L G  FGWG N  
Sbjct: 151  SWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSA 210

Query: 220  GQLGLNDEN---DRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH 276
            GQL L+  N       P  + +L++  +VYI CG+ HTA LT++G VFTFG    GQLG+
Sbjct: 211  GQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGY 270

Query: 277  NSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336
            + T  +  P+ V E +  +V++I CG  HT A+V ++G++ SFG       G   TS   
Sbjct: 271  SPTPEKRGPQLV-ERIDGLVSQIDCGSYHTLAYVHTTGQVVSFG------HGPSDTSKPT 323

Query: 337  SPFTVKGNWYPYNGQCLPDIDSEEYFCVKRIFSGGDQSF--SHYSSPQNCGPPDDFRCPN 394
             P  +  N   ++  CL   +      VK IF+G   +F  +H  +          R P 
Sbjct: 324  HPEALTEN---FDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSST-------RAPG 373

Query: 395  PT-KQIWTVNEALIQKWLSYPSGRFPVEIA-NEIDGTFSSSGCLNGSFLAVSNDDHYRTG 452
             T  +I  +++++ +KW++        E+A +EI   FSS  CL  SFL           
Sbjct: 374  KTLPEISRISQSMAEKWIAVKRRSTEHEMAKSEIRMIFSSPACLTASFLKKRGTGE---- 429

Query: 453  TRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPE 512
            T    VD+  AR  F KL + +   IS  +   LE +L+  L    P  EAL  +L LPE
Sbjct: 430  TTSIDVDLEMARDTFKKLTKKE--WISSMITTCLEDDLLRALPCHSPHQEALSVFLLLPE 487

Query: 513  CPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLK 572
            CP+M DS N+  + +PF  A+  + K  L+VL+  W+ L+      ++++ K  ++  L 
Sbjct: 488  CPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQMLKAAIISQL- 546

Query: 573  LYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQIIQYDKFYIHEVQELIDIRNDYI 632
                 +  ++    +  +   L +++ LH+VN K    +  + F I+E+  L++   D  
Sbjct: 547  -----LHQTKTEQDHCNVKALLGMMKELHKVN-KANCRLPENTFNINELSNLLNFYIDRG 600

Query: 633  NWVQQQAYGMLADI--PVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLF 690
              + +  + + A+   PV    +PF+F++ +K  LLQ D+ ++MQM+  +A+     ++ 
Sbjct: 601  RQLFRDNHLIPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETIL 660

Query: 691  LPVIE-SVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEF 749
                E   +P  IL VRR  +V DA+  L + +  D+ K L V F+ E   ++GGV  EF
Sbjct: 661  QKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEF 720

Query: 750  FLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNCTIVDLHFP 809
            F  +  E+  P+YGMF Y E    +WF  K   +   + L G++CGL+++N  + +L FP
Sbjct: 721  FHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFP 780

Query: 810  LALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVK 869
            LALYKKLL +KPSL+DLKEL P +G+S+Q++LD   DDI +  C+ F+I   ++   +V 
Sbjct: 781  LALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSI---HWDQNDV- 836

Query: 870  ELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNEL 929
            +L+ NG    V++ N++++V  Y+DYIFN SV ++++ F  GF++VC  ++L  F P EL
Sbjct: 837  DLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEEL 896

Query: 930  QAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRI 989
               +IGNT+YDWK+ E+N++Y+  Y   HPTI++FW+ FH+L L++KK+FL FLTG DR+
Sbjct: 897  MTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRL 956

Query: 990  PILGMKSLKLVIQSTGG-GEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
               G++ +++V +      E   P S TC N+L LPKY+  E +   L  AI++N GF
Sbjct: 957  HARGIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014



 Score =  140 bits (352), Expect = 8e-33
 Identities = 96/276 (34%), Positives = 146/276 (52%), Gaps = 11/276 (3%)

Query: 1   MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRD-VGCGLRHTVFVLDDGTVYTCG 59
           +L  G+ S GQLG  G     + EP ++   +   + D V CG  H++ V   G V+  G
Sbjct: 44  VLSCGDNSRGQLGRRGAQRGELPEPIQA---LETLIVDLVSCGKEHSLAVCHKGRVFAWG 100

Query: 60  CNDLGQLGHEKSRK---KPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQL 116
               GQLG  + ++    P++++ L+   I+ VSCG  H+LAL+   QV++WG +S GQL
Sbjct: 101 AGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQL 160

Query: 117 GLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGL-GTDC 175
           GL         P+ ++SL  I + QVA G  HS ALS     F WG N  GQL L G + 
Sbjct: 161 GLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNV 220

Query: 176 KKQTS-PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPN 234
             Q++ P  + +L  +  + ++ G AH+ VLT  G +F +G N+ GQLG +   ++  P 
Sbjct: 221 PVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQ 280

Query: 235 LLKSLRSQKIVYICCGEDHTAA-LTKEGGVFTFGAG 269
           L++ +    +  I CG  HT A +   G V +FG G
Sbjct: 281 LVERI-DGLVSQIDCGSYHTLAYVHTTGQVVSFGHG 315



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 58/192 (30%), Positives = 96/192 (50%), Gaps = 4/192 (2%)

Query: 138 QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAA 197
           +++Q A G  HSL L     V   G N  GQLG     ++   P+ +++L  +    V+ 
Sbjct: 24  ELLQAASGERHSLLLLTNHRVLSCGDNSRGQLG-RRGAQRGELPEPIQALETLIVDLVSC 82

Query: 198 GGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND-RYVPNLLKSLRSQKIVYICCGEDHTAA 256
           G  HS  +   G +F WG    GQLG+ +  +  + P  + +L   KI+ + CG  H+ A
Sbjct: 83  GKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLA 142

Query: 257 LTKEGGVFTFGAGGYGQLG-HNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGR 315
           L+K+  VF++G   +GQLG       + +P++V  L G  + ++A G  H+ A +   G 
Sbjct: 143 LSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA-LSLCGT 201

Query: 316 IYSFGLGGNGQL 327
            + +G    GQL
Sbjct: 202 SFGWGSNSAGQL 213



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 48/173 (27%), Positives = 82/173 (47%), Gaps = 13/173 (7%)

Query: 159 FCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNK 218
           FCWG +            ++   +      G   +Q A+G  HS +L  +  +   G N 
Sbjct: 3   FCWGADS-----------RELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNS 51

Query: 219 FGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNS 278
            GQLG        +P  +++L +  +  + CG++H+ A+  +G VF +GAG  GQLG   
Sbjct: 52  RGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGE 111

Query: 279 TSH-EINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330
                  P+K+  L    + +++CG  H+ A    S +++S+G   +GQLG G
Sbjct: 112 FKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDS-QVFSWGKNSHGQLGLG 163


>gi|110825982 hect domain and RLD 5 [Homo sapiens]
          Length = 1024

 Score =  634 bits (1635), Expect = 0.0
 Identities = 348/925 (37%), Positives = 541/925 (58%), Gaps = 48/925 (5%)

Query: 134  LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFM 193
            L + +I+Q+ CG YHSLALSK  E+F WGQN +GQLG+G      T+PQ+++ L G+P  
Sbjct: 135  LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194

Query: 194  QVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDH 253
            Q++AG AHS  L++SG I+ WG+N+ GQLGL     +  P+L++ L +QK+ ++ CG  H
Sbjct: 195  QISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSH 254

Query: 254  TAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSS 313
            +A LT++G +FTFGAG +GQLGHNST +E+ P  V EL+G  VT+IACGR HT A+V   
Sbjct: 255  SALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDL 314

Query: 314  GRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKRI--FSGG 371
            G+++SFG G +GQLG G T ++  P  VK +          ++  E +   K +   +GG
Sbjct: 315  GKVFSFGSGKDGQLGNGGTRDQLMPLPVKVS-------SSEELKLESHTSEKELIMIAGG 367

Query: 372  DQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFS 431
            +QS   +   +N          N  + I T+NE  +++W++    +       EI   FS
Sbjct: 368  NQSILLWIKKEN-------SYVNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQEIFS 420

Query: 432  SSGCLNGSFLAVSNDDHYRTGTRFSGV--DMNAARLLFHKLIQPDHPQISQQVAASLEKN 489
            S  CL GSFL        R  T    V  D+N AR +F +L Q D   I+  +   L+ N
Sbjct: 421  SPACLTGSFL------RKRRTTEMMPVYLDLNKARNIFKELTQKD--WITNMITTCLKDN 472

Query: 490  LIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWS 549
            L+ +L    P  EAL  +  LPECP+M  SNN+ ++ +PF   +  +      VLE +W+
Sbjct: 473  LLKRLPFHSPPQEALEIFFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWA 532

Query: 550  VLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQ 609
             L+   F K+V++FK  V+  L  +       E    N  +   L++L+ LHRVN+   Q
Sbjct: 533  TLQESTFSKLVQMFKTAVICQLDYW------DESAEENGNVQALLEMLKKLHRVNQVKCQ 586

Query: 610  IIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMLADIP------VTICTYPFVFDAQAKT 663
            + +     I +V EL+   N ++   ++  + M  D        V    +PF+F+  +K 
Sbjct: 587  LPE----SIFQVDELLHRLNFFVEVCRRYLWKMTVDASENVQCCVIFSHFPFIFNNLSKI 642

Query: 664  TLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIE-SVNPCLILVVRRENIVGDAMEVLRKTK 722
             LL TD +L+++    +A+ ++ +       E ++ P   L VRR +++ D +  L + +
Sbjct: 643  KLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQLSQFE 702

Query: 723  NIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFE 782
            N D +K L V F GE   D GGV+KEFF  +  E++ P+YGMF Y E +  +WF  K   
Sbjct: 703  NEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKF 762

Query: 783  DSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLD 842
            +   +   GV+CGL+++NC + +L FPLAL+KKLL + PSL+DLKEL PD+G+++Q LLD
Sbjct: 763  EKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLD 822

Query: 843  YPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVA 902
               D+ EE F ++F +  +         L+ NG+   VN+ N++++V  Y++YIFN SV 
Sbjct: 823  DEGDNFEEVFYIHFNVHWDR----NDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVK 878

Query: 903  SLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIK 962
            ++++ F  GF+K+C   ++ LF P EL+ +++GNT+YDWK  EKN  Y+  Y + HPTI 
Sbjct: 879  AVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIV 938

Query: 963  IFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPV-SHTCFNLL 1021
            +FW+ FH+L LE+KK+FL+FLTG+DR+ +  + ++K+         E  P+ + TCF++L
Sbjct: 939  MFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWNERDPIRALTCFSVL 998

Query: 1022 DLPKYTEKETLRSKLIQAIDHNEGF 1046
             LPKY+  ET+   L +AI++N GF
Sbjct: 999  FLPKYSTMETVEEALQEAINNNRGF 1023



 Score =  149 bits (376), Expect = 1e-35
 Identities = 84/257 (32%), Positives = 134/257 (52%), Gaps = 11/257 (4%)

Query: 33  NKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCG 92
           N ++  V  G  H + +  DG  +      +  L  E           L  + I+ ++CG
Sbjct: 96  NMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFES---------ILQEKKIIQITCG 146

Query: 93  EAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLAL 152
           + H+LAL+  G+++AWG +  GQLG+         P+ ++ L+ + + Q++ G  HS+AL
Sbjct: 147 DYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMAL 206

Query: 153 SKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212
           S +  ++ WG+N+ GQLGLG   + +  P L++ L       VA GG+HS +LT  G +F
Sbjct: 207 SMSGNIYSWGKNECGQLGLG-HTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLF 265

Query: 213 GWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKE-GGVFTFGAGGY 271
            +G  K GQLG N   +   P L+  L   ++  I CG  HT A   + G VF+FG+G  
Sbjct: 266 TFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKD 325

Query: 272 GQLGHNSTSHEINPRKV 288
           GQLG+  T  ++ P  V
Sbjct: 326 GQLGNGGTRDQLMPLPV 342



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 55/175 (31%), Positives = 89/175 (50%), Gaps = 5/175 (2%)

Query: 1   MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
           +  WG    GQLG+G         P+  +      +  +  G  H++ +   G +Y+ G 
Sbjct: 159 LFAWGQNLHGQLGVGR-KFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGK 217

Query: 61  NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118
           N+ GQ  LGH +S+  P  +  LD Q +  V+CG +H+  L   G ++ +G    GQLG 
Sbjct: 218 NECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGH 277

Query: 119 VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLA-LSKASEVFCWGQNKYGQLGLG 172
             ++  +R P  +  L   ++ Q+ACG +H+LA +S   +VF +G  K GQLG G
Sbjct: 278 NSTQNELR-PCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNG 331



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 45/140 (32%), Positives = 77/140 (55%), Gaps = 6/140 (4%)

Query: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
           WG    GQLGLG  + +   +P   +   N++V  V CG  H+  +  DG ++T G    
Sbjct: 215 WGKNECGQLGLGHTESKD--DPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKH 272

Query: 64  GQLGHEKSRK--KPEQVVALDAQNIVAVSCGEAHTLA-LNDKGQVYAWGLDSDGQLGLVG 120
           GQLGH  ++   +P  V  L    +  ++CG  HTLA ++D G+V+++G   DGQLG  G
Sbjct: 273 GQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGG 332

Query: 121 S-EECIRVPRNIKSLSDIQI 139
           + ++ + +P  + S  ++++
Sbjct: 333 TRDQLMPLPVKVSSSEELKL 352


>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
          Length = 776

 Score =  306 bits (785), Expect = 5e-83
 Identities = 194/561 (34%), Positives = 296/561 (52%), Gaps = 30/561 (5%)

Query: 504  LRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVE-L 562
            LR Y  L + P  ++++ +   A      +  L +A    L +W+  L    F ++VE L
Sbjct: 229  LRAYFILLQNPQFNNTSTYVIYAHLL-RQIATLVEADHHFLVHWFKKLSQKRFKQLVERL 287

Query: 563  FKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQ-IIQYDKFYIHEV 621
             + + + L        PP  +  +  ++ +A KVL +L+  N  +   +I Y  FY +  
Sbjct: 288  LQFISLRLFPAKPEEFPPITKCSW--WIPSAAKVLALLNTANNLVHPPLIPYTDFY-NST 344

Query: 622  QELIDIRNDYINWVQQQAYGMLADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQA 681
             + ID+  +Y  W   Q +G       + C YPFV    AK  ++Q D+  QM     Q+
Sbjct: 345  LDHIDLMEEYHTW---QNFGNSHRF--SFCQYPFVISVAAKKIIIQRDSEQQMINIARQS 399

Query: 682  HRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVD 741
                VS    P +  +   L + VRR ++V D+++ L + K  D KK LKV FVGE  +D
Sbjct: 400  LVDKVSRRQRPDMNIL--FLNMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGEAGLD 456

Query: 742  AGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNC 801
             GG+ KE+FLL++R++  P YGMF Y++DS   WFS    ++   F L+G++ GLA+YN 
Sbjct: 457  MGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNS 516

Query: 802  TIVDLHFPLALYKKLLKK--------------KPSLDDLKELMPDVGRSMQQLLDYPEDD 847
              +D+ FP   YKKLL                  ++DDL ++MP++   + +LL + E +
Sbjct: 517  ITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSH-EGN 575

Query: 848  IEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDA 907
            +EE F   F +  E FG  +   L   G   +V  QNR+E+V  Y D++ NKS+   F A
Sbjct: 576  VEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAA 635

Query: 908  FHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEV 967
            F+ GFH VC    L+L +P E++ +V G+ + D   L+++T+Y G Y     TIK FW+V
Sbjct: 636  FYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHALQRSTQYDG-YAKTDLTIKYFWDV 694

Query: 968  FHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLPKYT 1027
                PL+ +K+ L F TGSDR+P+ GM  L   I         LPV+HTCFN L LP Y 
Sbjct: 695  VLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCFNQLCLPPYK 754

Query: 1028 EKETLRSKLIQAIDHNEGFSL 1048
             K+ L+ KLI  I ++EGF L
Sbjct: 755  SKKDLKQKLIIGISNSEGFGL 775


>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
          Length = 872

 Score =  301 bits (772), Expect = 2e-81
 Identities = 168/445 (37%), Positives = 260/445 (58%), Gaps = 17/445 (3%)

Query: 610  IIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMLADIPVTICTYPFVFDAQAKTTLLQTD 669
            +I +++F    + E++++  DY        + +  +   +  T PF+ +A  K   L  D
Sbjct: 440  LIPFEEFINEPLNEVLEMDKDYT------FFKVETENKFSFMTCPFILNAVTKNLGLYYD 493

Query: 670  AVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAM---EVLRKTKNIDY 726
              ++M      + R+      L   + +NP L L VRR++I+ DA+   E++      D 
Sbjct: 494  NRIRMY-----SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADL 548

Query: 727  KKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDL 786
            KK L V F GE  VD GGV KEFF L++ E+ +P  GMF Y E ++L WF+  +FE    
Sbjct: 549  KKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ 608

Query: 787  FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPED 846
            F LIG++ GLAIYN  I+D+HFP+ +Y+KL+ KK +  DL +  P + +S++ LL+Y E 
Sbjct: 609  FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EG 667

Query: 847  DIEETFCLNFTIT-VENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLF 905
            ++E+   + F I+  + FG   + +L  NG    +  +NR+EFV+ Y DYI NKSV   F
Sbjct: 668  NVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQF 727

Query: 906  DAFHAGFHKVCGGKVL-LLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIF 964
             AF  GFH V     L  LF+P E++ ++ G+ N D++ LE+ TEY G Y  +   I+ F
Sbjct: 728  KAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREF 787

Query: 965  WEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLP 1024
            WE+ H    E+K+ FL F TG+DR P+ G+  LK++I   G   E LP SHTCFN+L LP
Sbjct: 788  WEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLP 847

Query: 1025 KYTEKETLRSKLIQAIDHNEGFSLI 1049
            +Y+ KE L+ +L++AI + +GF ++
Sbjct: 848  EYSSKEKLKERLLKAITYAKGFGML 872


>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
          Length = 852

 Score =  301 bits (772), Expect = 2e-81
 Identities = 168/445 (37%), Positives = 260/445 (58%), Gaps = 17/445 (3%)

Query: 610  IIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMLADIPVTICTYPFVFDAQAKTTLLQTD 669
            +I +++F    + E++++  DY        + +  +   +  T PF+ +A  K   L  D
Sbjct: 420  LIPFEEFINEPLNEVLEMDKDYT------FFKVETENKFSFMTCPFILNAVTKNLGLYYD 473

Query: 670  AVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAM---EVLRKTKNIDY 726
              ++M      + R+      L   + +NP L L VRR++I+ DA+   E++      D 
Sbjct: 474  NRIRMY-----SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADL 528

Query: 727  KKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDL 786
            KK L V F GE  VD GGV KEFF L++ E+ +P  GMF Y E ++L WF+  +FE    
Sbjct: 529  KKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ 588

Query: 787  FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPED 846
            F LIG++ GLAIYN  I+D+HFP+ +Y+KL+ KK +  DL +  P + +S++ LL+Y E 
Sbjct: 589  FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EG 647

Query: 847  DIEETFCLNFTIT-VENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLF 905
            ++E+   + F I+  + FG   + +L  NG    +  +NR+EFV+ Y DYI NKSV   F
Sbjct: 648  NVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQF 707

Query: 906  DAFHAGFHKVCGGKVL-LLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIF 964
             AF  GFH V     L  LF+P E++ ++ G+ N D++ LE+ TEY G Y  +   I+ F
Sbjct: 708  KAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREF 767

Query: 965  WEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLP 1024
            WE+ H    E+K+ FL F TG+DR P+ G+  LK++I   G   E LP SHTCFN+L LP
Sbjct: 768  WEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLP 827

Query: 1025 KYTEKETLRSKLIQAIDHNEGFSLI 1049
            +Y+ KE L+ +L++AI + +GF ++
Sbjct: 828  EYSSKEKLKERLLKAITYAKGFGML 852


>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
          Length = 875

 Score =  301 bits (772), Expect = 2e-81
 Identities = 168/445 (37%), Positives = 260/445 (58%), Gaps = 17/445 (3%)

Query: 610  IIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMLADIPVTICTYPFVFDAQAKTTLLQTD 669
            +I +++F    + E++++  DY        + +  +   +  T PF+ +A  K   L  D
Sbjct: 443  LIPFEEFINEPLNEVLEMDKDYT------FFKVETENKFSFMTCPFILNAVTKNLGLYYD 496

Query: 670  AVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAM---EVLRKTKNIDY 726
              ++M      + R+      L   + +NP L L VRR++I+ DA+   E++      D 
Sbjct: 497  NRIRMY-----SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADL 551

Query: 727  KKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDL 786
            KK L V F GE  VD GGV KEFF L++ E+ +P  GMF Y E ++L WF+  +FE    
Sbjct: 552  KKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ 611

Query: 787  FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPED 846
            F LIG++ GLAIYN  I+D+HFP+ +Y+KL+ KK +  DL +  P + +S++ LL+Y E 
Sbjct: 612  FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EG 670

Query: 847  DIEETFCLNFTIT-VENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLF 905
            ++E+   + F I+  + FG   + +L  NG    +  +NR+EFV+ Y DYI NKSV   F
Sbjct: 671  NVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQF 730

Query: 906  DAFHAGFHKVCGGKVL-LLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIF 964
             AF  GFH V     L  LF+P E++ ++ G+ N D++ LE+ TEY G Y  +   I+ F
Sbjct: 731  KAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREF 790

Query: 965  WEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLP 1024
            WE+ H    E+K+ FL F TG+DR P+ G+  LK++I   G   E LP SHTCFN+L LP
Sbjct: 791  WEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLP 850

Query: 1025 KYTEKETLRSKLIQAIDHNEGFSLI 1049
            +Y+ KE L+ +L++AI + +GF ++
Sbjct: 851  EYSSKEKLKERLLKAITYAKGFGML 875


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score =  188 bits (477), Expect = 3e-47
 Identities = 122/337 (36%), Positives = 173/337 (51%), Gaps = 10/337 (2%)

Query: 14   LGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRK 73
            LGG+    +  P  S+      V  V  G +    V  +G VY CG    G+LG   S  
Sbjct: 2972 LGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSG 3031

Query: 74   K---PEQVVALDAQNI--VAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVP 128
                P Q+ AL +  +  VAV  G  H  AL   G+V++WG   DG+LG      C + P
Sbjct: 3032 TVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDK-P 3090

Query: 129  RNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLL 188
            R I++L   +I  +ACG  HS AL+ + E++ WG  +YG+LG G D   Q  P+++K LL
Sbjct: 3091 RLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHG-DNTTQLKPKMVKVLL 3149

Query: 189  GIPFMQVAAGG--AHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVY 246
            G   +QVA G   A +  LT  G +F WG   FG+LG        +P  ++ L  Q +  
Sbjct: 3150 GHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQ 3209

Query: 247  ICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHT 306
            I CG   + ALTK G V+T+G G Y +LGH S  H   P+ V  L G  +  +A G  H 
Sbjct: 3210 IECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHC 3269

Query: 307  SAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343
             A V  SG++Y++G   +GQ G G+T+  + P  V+G
Sbjct: 3270 LA-VTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG 3305



 Score =  180 bits (456), Expect = 7e-45
 Identities = 117/341 (34%), Positives = 173/341 (50%), Gaps = 11/341 (3%)

Query: 4    WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
            WG+   GQLG  GI+   V  P   +     R   +  G +    V  DG +Y  G    
Sbjct: 3957 WGHNHRGQLG--GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAG 4014

Query: 64   GQLGHEKSRKKPEQVVALDAQNI----VAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLV 119
            G+LG   +       +    Q++    VAV+ G  H LAL+ +G+VY+WG   DG+LG  
Sbjct: 4015 GRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHG 4074

Query: 120  GSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQT 179
                C R PR I+SL  I++V VA G  HS  ++ A +++ WG+ +YG+LG  +D + Q 
Sbjct: 4075 NRSPCDR-PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLG-HSDSEDQL 4132

Query: 180  SPQLLKSLLGIPFMQVAAGG--AHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLK 237
             P+L+++L G   + +A G   A +  LT    ++ WG   +G+LG    +   VP  + 
Sbjct: 4133 KPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKID 4192

Query: 238  SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVT 297
            SL    +V + CG   + ALTK G V+T+G G Y +LGH S  H   PR+V  L G  V 
Sbjct: 4193 SLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVI 4252

Query: 298  EIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338
             IA G  H        G +Y++G    GQLG G+T+  + P
Sbjct: 4253 AIATGSLHCVCCT-EDGEVYTWGDNDEGQLGDGTTNAIQRP 4292



 Score =  168 bits (425), Expect = 3e-41
 Identities = 94/259 (36%), Positives = 139/259 (53%), Gaps = 8/259 (3%)

Query: 4    WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
            WG    G+LG          +PR  +    KR+RD+ CG  H+  +   G +YT G  + 
Sbjct: 3071 WGEGDDGKLG--HFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3128

Query: 64   GQLGH--EKSRKKPEQVVALDAQNIVAVSCG--EAHTLALNDKGQVYAWGLDSDGQLGLV 119
            G+LGH    ++ KP+ V  L    ++ V+CG  +A TLAL D+G V++WG    G+LG  
Sbjct: 3129 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3188

Query: 120  GSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQT 179
            GSE C  +P+NI+ L+   + Q+ CG   SLAL+K+  V+ WG+  Y +LG G+D   + 
Sbjct: 3189 GSEGC-NIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR- 3246

Query: 180  SPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSL 239
             PQ+++ L G   + VA G  H   +T SG ++ WG N  GQ G         P L++ L
Sbjct: 3247 KPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL 3306

Query: 240  RSQKIVYICCGEDHTAALT 258
              QKI  + CG  H+ A T
Sbjct: 3307 EGQKITRVACGSSHSVAWT 3325



 Score =  167 bits (424), Expect = 4e-41
 Identities = 106/299 (35%), Positives = 167/299 (55%), Gaps = 13/299 (4%)

Query: 53   GTVYTCGCNDLGQLGHEKSRKK--PEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGL 110
            GT+Y  G N  GQLG  +  K   P    AL     V +  GE    A+   G++YA G 
Sbjct: 3952 GTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGY 4011

Query: 111  DSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVA--CGYYHSLALSKASEVFCWGQNKYGQ 168
             + G+LG +G  E +  P  ++S+  + I +VA   G  H LALS   EV+ WG+ + G+
Sbjct: 4012 GAGGRLG-IGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 4070

Query: 169  LGLG--TDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLND 226
            LG G  + C +   P++++SL GI  + VAAGGAHS  +T +G ++ WG+ ++G+LG +D
Sbjct: 4071 LGHGNRSPCDR---PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSD 4127

Query: 227  ENDRYVPNLLKSLRSQKIVYICC--GEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEIN 284
              D+  P L+++L+  ++V I C  G+  T  LT +  V+++G G YG+LG   +     
Sbjct: 4128 SEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKV 4187

Query: 285  PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343
            P K+  L G  V ++ CG Q + A +  SG +Y++G G   +LG GS  + + P  V+G
Sbjct: 4188 PMKIDSLTGLGVVKVECGSQFSVA-LTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQG 4245



 Score =  162 bits (409), Expect = 2e-39
 Identities = 105/311 (33%), Positives = 160/311 (51%), Gaps = 9/311 (2%)

Query: 5    GNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGC--GLRHTVFVLDDGTVYTCGCND 62
            G A+ G+LGLG I    V  PR+     +  V+ V    G RH   +  DG V++ G  D
Sbjct: 3017 GEATNGRLGLG-ISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGD 3075

Query: 63   LGQLGH--EKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
             G+LGH    +  KP  + AL  + I  ++CG +H+ AL   G++Y WGL   G+LG  G
Sbjct: 3076 DGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGH-G 3134

Query: 121  SEECIRVPRNIKSLSDIQIVQVACGYY--HSLALSKASEVFCWGQNKYGQLGLGTDCKKQ 178
                   P+ +K L   +++QVACG     +LAL+    VF WG   +G+LG G   +  
Sbjct: 3135 DNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGS-EGC 3193

Query: 179  TSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKS 238
              PQ ++ L G    Q+  G   S  LT SG ++ WG+  + +LG   +     P +++ 
Sbjct: 3194 NIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEG 3253

Query: 239  LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTE 298
            LR +KIV++  G  H  A+T  G V+ +G   +GQ G+ +T+    P  V  L G  +T 
Sbjct: 3254 LRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITR 3313

Query: 299  IACGRQHTSAF 309
            +ACG  H+ A+
Sbjct: 3314 VACGSSHSVAW 3324



 Score =  154 bits (388), Expect = 5e-37
 Identities = 101/317 (31%), Positives = 163/317 (51%), Gaps = 16/317 (5%)

Query: 5    GNASFGQLGLGG---IDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCN 61
            G  + G+LG+GG   +    +LE  +  F   K+V  V  G +H + +  +G VY+ G  
Sbjct: 4010 GYGAGGRLGIGGTESVSTPTLLESIQHVFI--KKVA-VNSGGKHCLALSSEGEVYSWGEA 4066

Query: 62   DLGQLGHEKSRK--KPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLV 119
            + G+LGH       +P  + +L    +V V+ G AH+  +   G +Y WG    G+LG  
Sbjct: 4067 EDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHS 4126

Query: 120  GSEECIRVPRNIKSLSDIQIVQVACGY--YHSLALSKASEVFCWGQNKYGQLGLGTD--C 175
             SE+ ++ P+ +++L   ++V +ACG     +L L+    V+ WG   YG+LG G    C
Sbjct: 4127 DSEDQLK-PKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGC 4185

Query: 176  KKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235
            K    P  + SL G+  ++V  G   S  LT SGA++ WG+  + +LG   ++    P  
Sbjct: 4186 KV---PMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQ 4242

Query: 236  LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295
            ++ L+ +K++ I  G  H    T++G V+T+G    GQLG  +T+    PR V  L G  
Sbjct: 4243 VQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKK 4302

Query: 296  VTEIACGRQHTSAFVPS 312
            V  +ACG  HT A+  S
Sbjct: 4303 VNRVACGSAHTLAWSTS 4319



 Score =  143 bits (361), Expect = 7e-34
 Identities = 90/271 (33%), Positives = 146/271 (53%), Gaps = 10/271 (3%)

Query: 104  QVYAWGLDSDGQLG-LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWG 162
            +V+ WGL+   QLG L GS+  I+VP   ++LS + +VQVA G     A++   +V+  G
Sbjct: 2960 KVFVWGLNDKDQLGGLKGSK--IKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACG 3017

Query: 163  QNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVA--AGGAHSFVLTLSGAIFGWGRNKFG 220
            +   G+LGLG        P+ + +L      +VA  +GG H+  LT+ G +F WG    G
Sbjct: 3018 EATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDG 3077

Query: 221  QLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTS 280
            +LG     +   P L+++L++++I  I CG  H+AALT  G ++T+G G YG+LGH   +
Sbjct: 3078 KLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNT 3137

Query: 281  HEINPRKVFELMGSIVTEIACG-RQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPF 339
             ++ P+ V  L+G  V ++ACG R   +  +   G ++S+G G  G+LG G +     P 
Sbjct: 3138 TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQ 3197

Query: 340  TVKGNWYPYNGQCLPDIDSEEYFCVKRIFSG 370
             ++      NGQ +  I+    F +    SG
Sbjct: 3198 NIE----RLNGQGVCQIECGAQFSLALTKSG 3224



 Score =  142 bits (359), Expect = 1e-33
 Identities = 91/307 (29%), Positives = 152/307 (49%), Gaps = 19/307 (6%)

Query: 22  VLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVAL 81
           V+ P + +   N  V  + C  +  + +  +G VYT   N             P+ V  L
Sbjct: 439 VIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS--------DTLAPQLVQGL 490

Query: 82  DAQNIVAVSCGEA--HTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQ- 138
            ++NIV ++      H LAL   G+VY+WG    G+LG  G    +  P+ I + S  Q 
Sbjct: 491 ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGH-GDTVPLEEPKVISAFSGKQA 549

Query: 139 ---IVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQV 195
              +V +ACG  +S A++   E++ WG+  YG+LG G+  + +  P L+  L G+  + V
Sbjct: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDV 608

Query: 196 AAGG--AHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDH 253
           A G   A +  +T +G ++ WG   +G+LG    +    P L++ L+   +V + CG   
Sbjct: 609 ACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQF 668

Query: 254 TAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSS 313
           + ALTK+G V+++G G   +LGH +  H   P+ +  L G  V ++A G  H  A    S
Sbjct: 669 SIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDS 728

Query: 314 GRIYSFG 320
             ++S+G
Sbjct: 729 -EVHSWG 734



 Score =  130 bits (327), Expect = 6e-30
 Identities = 84/287 (29%), Positives = 146/287 (50%), Gaps = 16/287 (5%)

Query: 45  HTVFVLDDGTVYTCGCNDLGQLGHEKS--RKKPEQVVALDAQ----NIVAVSCGEAHTLA 98
           H + +   G VY+ GC D G+LGH  +   ++P+ + A   +    ++V ++CG  ++ A
Sbjct: 506 HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAA 565

Query: 99  LNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGY--YHSLALSKAS 156
           +  +G++Y WG  + G+LG  GS E   +P  +  L  ++++ VACG     +LA+++  
Sbjct: 566 ITAEGELYTWGRGNYGRLGH-GSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENG 624

Query: 157 EVFCWGQNKYGQLGLGTD--CKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGW 214
           +V+ WG   YG+LG G    CK   +P+L++ L  +  ++V  G   S  LT  G ++ W
Sbjct: 625 QVWSWGDGDYGKLGRGGSDGCK---TPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSW 681

Query: 215 GRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274
           G+    +LG   E     P LL+ L+ +K++ +  G  H  ALT++  V ++G+    Q 
Sbjct: 682 GKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQH 741

Query: 275 GHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGL 321
                  +  P  +  L    +  IACG     +F  SS   +S GL
Sbjct: 742 FDTLRVTKPEPAALPGLDTKHIVGIACG--PAQSFAWSSCSEWSIGL 786



 Score =  127 bits (320), Expect = 4e-29
 Identities = 88/329 (26%), Positives = 151/329 (45%), Gaps = 28/329 (8%)

Query: 75  PEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL 134
           P Q   L    +  ++C E   L L+  G+VY    +SD              P+ ++ L
Sbjct: 442 PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD-----------TLAPQLVQGL 490

Query: 135 SDIQIVQVACGY--YHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIP- 191
           +   IV++A     +H LAL+   EV+ WG    G+LG G D      P+++ +  G   
Sbjct: 491 ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHG-DTVPLEEPKVISAFSGKQA 549

Query: 192 ---FMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYIC 248
               + +A G  +S  +T  G ++ WGR  +G+LG     D  +P L+  L+  K++ + 
Sbjct: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609

Query: 249 CG--EDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHT 306
           CG  +  T A+T+ G V+++G G YG+LG   +     P+ + +L    V ++ CG Q +
Sbjct: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 669

Query: 307 SAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKR 366
            A     G++YS+G G N +LG G+  + + P  ++G      G+ + D+ +    C+  
Sbjct: 670 IALT-KDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG----LQGKKVIDVAAGSTHCLAL 724

Query: 367 IFSGGDQSFSHYSSPQNCGPPDDFRCPNP 395
                D     + S   C   D  R   P
Sbjct: 725 T---EDSEVHSWGSNDQCQHFDTLRVTKP 750



 Score =  103 bits (256), Expect = 1e-21
 Identities = 68/190 (35%), Positives = 99/190 (52%), Gaps = 5/190 (2%)

Query: 156  SEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWG 215
            ++VF WG N   QLG G    K   P   ++L  +  +QVA G    F +T+ G ++  G
Sbjct: 2959 TKVFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACG 3017

Query: 216  RNKFGQLGLNDENDRY-VPNLLKSLRSQ--KIVYICCGEDHTAALTKEGGVFTFGAGGYG 272
                G+LGL   +    +P  + +L S   K V +  G  H  ALT +G VF++G G  G
Sbjct: 3018 EATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDG 3077

Query: 273  QLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST 332
            +LGH S  +   PR +  L    + +IACG  H SA + SSG +Y++GLG  G+LG G  
Sbjct: 3078 KLGHFSRMNCDKPRLIEALKTKRIRDIACGSSH-SAALTSSGELYTWGLGEYGRLGHGDN 3136

Query: 333  SNRKSPFTVK 342
            + +  P  VK
Sbjct: 3137 TTQLKPKMVK 3146



 Score =  100 bits (250), Expect = 5e-21
 Identities = 69/204 (33%), Positives = 104/204 (50%), Gaps = 8/204 (3%)

Query: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGL--RHTVFVLDDGTVYTCGCN 61
           WG  ++G+LG G  ++E +  P         +V DV CG     T+ V ++G V++ G  
Sbjct: 575 WGRGNYGRLGHGSSEDEAI--PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG 632

Query: 62  DLGQLGHEKSR--KKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLV 119
           D G+LG   S   K P+ +  L   ++V V CG   ++AL   GQVY+WG   + +LG  
Sbjct: 633 DYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLG-H 691

Query: 120 GSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQT 179
           G+EE +R P+ ++ L   +++ VA G  H LAL++ SEV  WG N   Q    T    + 
Sbjct: 692 GTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ-HFDTLRVTKP 750

Query: 180 SPQLLKSLLGIPFMQVAAGGAHSF 203
            P  L  L     + +A G A SF
Sbjct: 751 EPAALPGLDTKHIVGIACGPAQSF 774



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 92/328 (28%), Positives = 144/328 (43%), Gaps = 27/328 (8%)

Query: 731  KVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSR----------LIWFSDKT 780
            KV FVGE   D GG   E    I  EL +    +     + R          L+  + + 
Sbjct: 4467 KVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARA 4526

Query: 781  FEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQL 840
               S +F  +GV+ G+AI   + + L+    ++K+L     ++ DL E+  D    +  +
Sbjct: 4527 PVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYI 4586

Query: 841  LDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYI---F 897
             D  E   EE   ++   TV +    +++   L+   T +   NR E+V   ++Y    F
Sbjct: 4587 RDN-EATSEEFEAMSLPFTVPSASGQDIQ---LSSKHTHITLDNRAEYVRLAINYRLHEF 4642

Query: 898  NKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAE 957
            ++ VA    A   G  +V    +L LF   EL+ MV G+ +     L+    YKG     
Sbjct: 4643 DEQVA----AVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPS 4697

Query: 958  HPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIP--ILGMKSLKLVIQ---STGGGEEYLP 1012
               I+ FWEV       ++  FL F+ G  R+P  I   +    VIQ        + +LP
Sbjct: 4698 ASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLP 4757

Query: 1013 VSHTCFNLLDLPKYTEKETLRSKLIQAI 1040
             S+TCF LL LP+Y+ K+ L  KL  AI
Sbjct: 4758 ESYTCFFLLKLPRYSCKQVLEEKLKYAI 4785



 Score = 90.5 bits (223), Expect = 7e-18
 Identities = 60/196 (30%), Positives = 99/196 (50%), Gaps = 4/196 (2%)

Query: 149  SLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLS 208
            +L+   +  ++ WG N  GQLG G +  K   P   ++L  +  +Q+  G    F +T  
Sbjct: 3945 TLSAGGSGTIYGWGHNHRGQLG-GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTAD 4003

Query: 209  GAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQ--KIVYICCGEDHTAALTKEGGVFTF 266
            G ++  G    G+LG+        P LL+S++    K V +  G  H  AL+ EG V+++
Sbjct: 4004 GKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSW 4063

Query: 267  GAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQ 326
            G    G+LGH + S    PR +  L G  V ++A G  H SA V ++G +Y++G G  G+
Sbjct: 4064 GEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAH-SACVTAAGDLYTWGKGRYGR 4122

Query: 327  LGTGSTSNRKSPFTVK 342
            LG   + ++  P  V+
Sbjct: 4123 LGHSDSEDQLKPKLVE 4138



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 49/160 (30%), Positives = 78/160 (48%), Gaps = 13/160 (8%)

Query: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
           WG+  +G+LG GG D      P+  +   +  V  V CG + ++ +  DG VY+ G  D 
Sbjct: 629 WGDGDYGKLGRGGSDG--CKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDN 686

Query: 64  GQLGH--EKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGS 121
            +LGH  E+  + P+ +  L  + ++ V+ G  H LAL +  +V++WG +   Q      
Sbjct: 687 QRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ-----H 741

Query: 122 EECIRV----PRNIKSLSDIQIVQVACGYYHSLALSKASE 157
            + +RV    P  +  L    IV +ACG   S A S  SE
Sbjct: 742 FDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSE 781



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 37/117 (31%), Positives = 53/117 (45%), Gaps = 13/117 (11%)

Query: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
           WG     +LG G   EE V  P+  +    K+V DV  G  H + + +D  V++ G ND 
Sbjct: 681 WGKGDNQRLGHG--TEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQ 738

Query: 64  GQLGHEKSRKKPEQVV--ALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118
            Q        KPE      LD ++IV ++CG A         Q +AW   S+  +GL
Sbjct: 739 CQHFDTLRVTKPEPAALPGLDTKHIVGIACGPA---------QSFAWSSCSEWSIGL 786


>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
            ligase 2 [Homo sapiens]
          Length = 1572

 Score =  180 bits (456), Expect = 7e-45
 Identities = 114/359 (31%), Positives = 182/359 (50%), Gaps = 14/359 (3%)

Query: 701  LILVVRRENIVGDAMEVLRKTKNIDYKK-PLKVIFVGEDAVDAGGVRKEFFLLIMRELLD 759
            L L++RR++++ DA   +      D ++  L V FVGE+ +D  G  +EFF L+ REL +
Sbjct: 1216 LKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFN 1275

Query: 760  PKYGMFRYY-EDSRLIWFSDKT-FEDS--DLFHLIGVICGLAIYNCTIVDLHFPLALYKK 815
            P YG+F Y   D+  +  S  + F D+  + F   G I GLA+ +  ++D  F    YK 
Sbjct: 1276 PYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKA 1335

Query: 816  LLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNG 875
            LL+    L DL+ L  +  +S+Q + D   +DI +   L FT+  E FG    +EL   G
Sbjct: 1336 LLRILCDLSDLEYLDEEFHQSLQWMKD---NDIHDILDLTFTVNEEVFGQITERELKPGG 1392

Query: 876  ADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG 935
            A+  V ++N++E+++  V +   + V    ++   GF++V   +++ +F   EL+ ++ G
Sbjct: 1393 ANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAG 1452

Query: 936  NTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMK 995
                D  +   NTEY+G Y   H  I+ FW        E++ + L F+TG+  IP  G  
Sbjct: 1453 TAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFA 1512

Query: 996  SL------KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1048
            SL      +       G    LP +HTCFN LDLP Y     L  KL+ A++    F L
Sbjct: 1513 SLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGL 1571


>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
            isoform 2 [Homo sapiens]
          Length = 431

 Score =  179 bits (454), Expect = 1e-44
 Identities = 115/356 (32%), Positives = 185/356 (51%), Gaps = 21/356 (5%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 764
            V R+ +  D+ + +   K  D ++ L +I  GE+ +D GG+ +E+F L+  E+L+P Y +
Sbjct: 80   VSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCL 139

Query: 765  FRYY-EDSRLIWFSDKTFEDSD---LFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 820
            F Y  +++  +  +  +  + D    F  IG    +A+Y+   +D  F L  YK++L K+
Sbjct: 140  FEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKR 199

Query: 821  PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFC-LNFTITVENFGATEVKELVLNGADTA 879
            P+L DL+ + P+   S+  +    E+++EE    L F   +E  G     EL   G    
Sbjct: 200  PTLKDLESIDPEFYNSIVWI---KENNLEECGLELYFIQDMEILGKVTTHELKEGGESIR 256

Query: 880  VNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNY 939
            V ++N++E++    D+ F + V     AF  GF++V   + L  F   EL+ M+ G    
Sbjct: 257  VTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEI 316

Query: 940  DWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKL 999
            D  + +K+T Y+  Y      I+ FW+V  E+  EK+ + L F+TG+ R+P+ G   L  
Sbjct: 317  DMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAEL-- 373

Query: 1000 VIQSTG---------GGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
             I S G         G E +LP SHTCFN LDLP Y   E LR KL+ AI+  EGF
Sbjct: 374  -IGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 428


>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
            isoform 1 [Homo sapiens]
          Length = 870

 Score =  179 bits (454), Expect = 1e-44
 Identities = 115/356 (32%), Positives = 185/356 (51%), Gaps = 21/356 (5%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 764
            V R+ +  D+ + +   K  D ++ L +I  GE+ +D GG+ +E+F L+  E+L+P Y +
Sbjct: 519  VSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCL 578

Query: 765  FRYY-EDSRLIWFSDKTFEDSD---LFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 820
            F Y  +++  +  +  +  + D    F  IG    +A+Y+   +D  F L  YK++L K+
Sbjct: 579  FEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKR 638

Query: 821  PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFC-LNFTITVENFGATEVKELVLNGADTA 879
            P+L DL+ + P+   S+  +    E+++EE    L F   +E  G     EL   G    
Sbjct: 639  PTLKDLESIDPEFYNSIVWI---KENNLEECGLELYFIQDMEILGKVTTHELKEGGESIR 695

Query: 880  VNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNY 939
            V ++N++E++    D+ F + V     AF  GF++V   + L  F   EL+ M+ G    
Sbjct: 696  VTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEI 755

Query: 940  DWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKL 999
            D  + +K+T Y+  Y      I+ FW+V  E+  EK+ + L F+TG+ R+P+ G   L  
Sbjct: 756  DMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAEL-- 812

Query: 1000 VIQSTG---------GGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
             I S G         G E +LP SHTCFN LDLP Y   E LR KL+ AI+  EGF
Sbjct: 813  -IGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 867


>gi|222352183 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  177 bits (448), Expect = 6e-44
 Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763
            + R NI  ++   +   K  D  K  L + F  E  +D GGV +E+F L+ +E+ +P YG
Sbjct: 501  LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560

Query: 764  MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
            +F Y   D+  +  +  +     +    F  IG + GLA+++  ++D  F    YK +L 
Sbjct: 561  LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620

Query: 819  KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878
            K+ +L+D++ +  +   S++ +L+    +++  FC++     ENFG T   +L  NG++ 
Sbjct: 621  KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 676

Query: 879  AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938
             V  +N++E++D  + + F   V    +AF  GF ++    ++ +F  NEL+ ++ G  +
Sbjct: 677  MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 736

Query: 939  YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997
             D  +  +++ YK  Y   HP I+ FW+    +  EK+ + L F+TG+ R+P+ G   L 
Sbjct: 737  VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 796

Query: 998  -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
                 +L      G  E LP +HTCFN LDLP Y   E LR KL+ A+++ +GF
Sbjct: 797  GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850


>gi|21361472 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score =  177 bits (448), Expect = 6e-44
 Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763
            + R NI  ++   +   K  D  K  L + F  E  +D GGV +E+F L+ +E+ +P YG
Sbjct: 602  LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 661

Query: 764  MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
            +F Y   D+  +  +  +     +    F  IG + GLA+++  ++D  F    YK +L 
Sbjct: 662  LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 721

Query: 819  KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878
            K+ +L+D++ +  +   S++ +L+    +++  FC++     ENFG T   +L  NG++ 
Sbjct: 722  KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 777

Query: 879  AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938
             V  +N++E++D  + + F   V    +AF  GF ++    ++ +F  NEL+ ++ G  +
Sbjct: 778  MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 837

Query: 939  YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997
             D  +  +++ YK  Y   HP I+ FW+    +  EK+ + L F+TG+ R+P+ G   L 
Sbjct: 838  VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 897

Query: 998  -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
                 +L      G  E LP +HTCFN LDLP Y   E LR KL+ A+++ +GF
Sbjct: 898  GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951


>gi|222352094 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  177 bits (448), Expect = 6e-44
 Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763
            + R NI  ++   +   K  D  K  L + F  E  +D GGV +E+F L+ +E+ +P YG
Sbjct: 481  LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540

Query: 764  MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
            +F Y   D+  +  +  +     +    F  IG + GLA+++  ++D  F    YK +L 
Sbjct: 541  LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600

Query: 819  KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878
            K+ +L+D++ +  +   S++ +L+    +++  FC++     ENFG T   +L  NG++ 
Sbjct: 601  KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 656

Query: 879  AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938
             V  +N++E++D  + + F   V    +AF  GF ++    ++ +F  NEL+ ++ G  +
Sbjct: 657  MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 716

Query: 939  YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997
             D  +  +++ YK  Y   HP I+ FW+    +  EK+ + L F+TG+ R+P+ G   L 
Sbjct: 717  VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 776

Query: 998  -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
                 +L      G  E LP +HTCFN LDLP Y   E LR KL+ A+++ +GF
Sbjct: 777  GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830


>gi|222352092 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  177 bits (448), Expect = 6e-44
 Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763
            + R NI  ++   +   K  D  K  L + F  E  +D GGV +E+F L+ +E+ +P YG
Sbjct: 481  LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540

Query: 764  MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
            +F Y   D+  +  +  +     +    F  IG + GLA+++  ++D  F    YK +L 
Sbjct: 541  LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600

Query: 819  KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878
            K+ +L+D++ +  +   S++ +L+    +++  FC++     ENFG T   +L  NG++ 
Sbjct: 601  KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 656

Query: 879  AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938
             V  +N++E++D  + + F   V    +AF  GF ++    ++ +F  NEL+ ++ G  +
Sbjct: 657  MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 716

Query: 939  YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997
             D  +  +++ YK  Y   HP I+ FW+    +  EK+ + L F+TG+ R+P+ G   L 
Sbjct: 717  VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 776

Query: 998  -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
                 +L      G  E LP +HTCFN LDLP Y   E LR KL+ A+++ +GF
Sbjct: 777  GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830


>gi|222352090 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 5 [Homo sapiens]
          Length = 947

 Score =  177 bits (448), Expect = 6e-44
 Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763
            + R NI  ++   +   K  D  K  L + F  E  +D GGV +E+F L+ +E+ +P YG
Sbjct: 594  LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 653

Query: 764  MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
            +F Y   D+  +  +  +     +    F  IG + GLA+++  ++D  F    YK +L 
Sbjct: 654  LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 713

Query: 819  KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878
            K+ +L+D++ +  +   S++ +L+    +++  FC++     ENFG T   +L  NG++ 
Sbjct: 714  KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 769

Query: 879  AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938
             V  +N++E++D  + + F   V    +AF  GF ++    ++ +F  NEL+ ++ G  +
Sbjct: 770  MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 829

Query: 939  YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997
             D  +  +++ YK  Y   HP I+ FW+    +  EK+ + L F+TG+ R+P+ G   L 
Sbjct: 830  VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 889

Query: 998  -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
                 +L      G  E LP +HTCFN LDLP Y   E LR KL+ A+++ +GF
Sbjct: 890  GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 943


>gi|222352088 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 4 [Homo sapiens]
          Length = 967

 Score =  177 bits (448), Expect = 6e-44
 Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763
            + R NI  ++   +   K  D  K  L + F  E  +D GGV +E+F L+ +E+ +P YG
Sbjct: 614  LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 673

Query: 764  MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
            +F Y   D+  +  +  +     +    F  IG + GLA+++  ++D  F    YK +L 
Sbjct: 674  LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 733

Query: 819  KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878
            K+ +L+D++ +  +   S++ +L+    +++  FC++     ENFG T   +L  NG++ 
Sbjct: 734  KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 789

Query: 879  AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938
             V  +N++E++D  + + F   V    +AF  GF ++    ++ +F  NEL+ ++ G  +
Sbjct: 790  MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 849

Query: 939  YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997
             D  +  +++ YK  Y   HP I+ FW+    +  EK+ + L F+TG+ R+P+ G   L 
Sbjct: 850  VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 909

Query: 998  -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
                 +L      G  E LP +HTCFN LDLP Y   E LR KL+ A+++ +GF
Sbjct: 910  GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 963


>gi|222352086 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 1 [Homo sapiens]
          Length = 975

 Score =  177 bits (448), Expect = 6e-44
 Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763
            + R NI  ++   +   K  D  K  L + F  E  +D GGV +E+F L+ +E+ +P YG
Sbjct: 622  LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 681

Query: 764  MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
            +F Y   D+  +  +  +     +    F  IG + GLA+++  ++D  F    YK +L 
Sbjct: 682  LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 741

Query: 819  KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878
            K+ +L+D++ +  +   S++ +L+    +++  FC++     ENFG T   +L  NG++ 
Sbjct: 742  KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 797

Query: 879  AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938
             V  +N++E++D  + + F   V    +AF  GF ++    ++ +F  NEL+ ++ G  +
Sbjct: 798  MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 857

Query: 939  YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997
             D  +  +++ YK  Y   HP I+ FW+    +  EK+ + L F+TG+ R+P+ G   L 
Sbjct: 858  VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 917

Query: 998  -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
                 +L      G  E LP +HTCFN LDLP Y   E LR KL+ A+++ +GF
Sbjct: 918  GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 971


>gi|222352084 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  177 bits (448), Expect = 6e-44
 Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763
            + R NI  ++   +   K  D  K  L + F  E  +D GGV +E+F L+ +E+ +P YG
Sbjct: 501  LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560

Query: 764  MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
            +F Y   D+  +  +  +     +    F  IG + GLA+++  ++D  F    YK +L 
Sbjct: 561  LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620

Query: 819  KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878
            K+ +L+D++ +  +   S++ +L+    +++  FC++     ENFG T   +L  NG++ 
Sbjct: 621  KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 676

Query: 879  AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938
             V  +N++E++D  + + F   V    +AF  GF ++    ++ +F  NEL+ ++ G  +
Sbjct: 677  MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 736

Query: 939  YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997
             D  +  +++ YK  Y   HP I+ FW+    +  EK+ + L F+TG+ R+P+ G   L 
Sbjct: 737  VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 796

Query: 998  -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
                 +L      G  E LP +HTCFN LDLP Y   E LR KL+ A+++ +GF
Sbjct: 797  GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850


>gi|222352082 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  177 bits (448), Expect = 6e-44
 Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763
            + R NI  ++   +   K  D  K  L + F  E  +D GGV +E+F L+ +E+ +P YG
Sbjct: 501  LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560

Query: 764  MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
            +F Y   D+  +  +  +     +    F  IG + GLA+++  ++D  F    YK +L 
Sbjct: 561  LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620

Query: 819  KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878
            K+ +L+D++ +  +   S++ +L+    +++  FC++     ENFG T   +L  NG++ 
Sbjct: 621  KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 676

Query: 879  AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938
             V  +N++E++D  + + F   V    +AF  GF ++    ++ +F  NEL+ ++ G  +
Sbjct: 677  MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 736

Query: 939  YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997
             D  +  +++ YK  Y   HP I+ FW+    +  EK+ + L F+TG+ R+P+ G   L 
Sbjct: 737  VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 796

Query: 998  -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
                 +L      G  E LP +HTCFN LDLP Y   E LR KL+ A+++ +GF
Sbjct: 797  GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850


>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
            sapiens]
          Length = 748

 Score =  176 bits (447), Expect = 8e-44
 Identities = 112/355 (31%), Positives = 181/355 (50%), Gaps = 15/355 (4%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 764
            V RE I  ++   + K +  D  K L + F GE+ +D GGV +E+  L+  E+L+P YG+
Sbjct: 397  VSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGL 456

Query: 765  FRYYEDS----RLIWFSDKTFEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 820
            F+Y  D     ++   S    E    FH +G I G+A+++   +D  F L  YK+LL K 
Sbjct: 457  FQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKS 516

Query: 821  PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAV 880
             +LDD++ + PD+  S+  +L   E+DI       F +    +G     EL  NG    V
Sbjct: 517  ITLDDMELVDPDLHNSLVWIL---ENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPV 573

Query: 881  NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYD 940
            N++N++E+V  YV++ F + + + F A   GF++V    +L  F   EL+ ++ G    D
Sbjct: 574  NEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKID 633

Query: 941  WKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLK-- 998
              + + NT  K     +   +K FW+       E++ + L F+TGS R+P+ G K+L+  
Sbjct: 634  VNDWKVNTRLK-HCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGA 692

Query: 999  -----LVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1048
                   I         LP +HTCFN +D+P Y   E L  KL+ AI+   GF++
Sbjct: 693  AGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 747


>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
          Length = 1606

 Score =  176 bits (447), Expect = 8e-44
 Identities = 110/357 (30%), Positives = 182/357 (50%), Gaps = 14/357 (3%)

Query: 703  LVVRRENIV-GDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPK 761
            L++RR++++ G   +V+  ++    +  L V FVGE+ +D  G  +EFF L+ +EL +P 
Sbjct: 1252 LIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPY 1311

Query: 762  YGMFRY-YEDSRLIWFSD-KTFEDSDL--FHLIGVICGLAIYNCTIVDLHFPLALYKKLL 817
            YG+F Y   D+  +  S    F ++ L  F   G I GLA+ +  ++D  F    YK LL
Sbjct: 1312 YGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALL 1371

Query: 818  KKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGAD 877
            +    L DL+ L  +  +S+Q + D   ++I +   L FT+  E FG    +EL   GA+
Sbjct: 1372 RLPCDLSDLEYLDEEFHQSLQWMKD---NNITDILDLTFTVNEEVFGQVTERELKSGGAN 1428

Query: 878  TAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNT 937
            T V ++N++E+++  V +   + V    +A   GF++V   +++ +F   EL+ ++ G  
Sbjct: 1429 TQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTA 1488

Query: 938  NYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIP------I 991
              D  +   NTEY+G Y   H  I+ FW        E++ + L F+TG+  +P      +
Sbjct: 1489 EIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAAL 1548

Query: 992  LGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1048
             G   L+       G    LP +HTCFN LDLP Y     L  KL+ A++    F L
Sbjct: 1549 RGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGL 1605


>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
            sapiens]
          Length = 757

 Score =  176 bits (446), Expect = 1e-43
 Identities = 111/358 (31%), Positives = 184/358 (51%), Gaps = 18/358 (5%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 764
            V RE I  ++   + K +  D KK L V F GE+ +D GGV +E+  L+  E+L+P YG+
Sbjct: 403  VSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGL 462

Query: 765  FRYYEDS--RLIWFSDKTFEDSDL--FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 820
            F+Y  D+   L    D +     L  FH +G I GLA+++   ++  F +  YK+LL K 
Sbjct: 463  FQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKP 522

Query: 821  PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAV 880
              L DL+ + P++ +S+  +L   E+DI       F +    FG     EL  NG +  V
Sbjct: 523  IQLSDLESVDPELHKSLVWIL---ENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPV 579

Query: 881  NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYD 940
             ++N++E+V  YV++ F + + + F A   GF+++    +L  F   EL+ ++ G    D
Sbjct: 580  TEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKID 639

Query: 941  WKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLK-- 998
              + + NT  K    A+   ++ FW+       E++ + L F+TGS R+P+ G K+L+  
Sbjct: 640  LNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGS 698

Query: 999  --------LVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1048
                      I       + LP +HTCFN +D+P Y   E L  KL+ A++   GF++
Sbjct: 699  TGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 756


>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
            sapiens]
          Length = 731

 Score =  176 bits (446), Expect = 1e-43
 Identities = 111/358 (31%), Positives = 184/358 (51%), Gaps = 18/358 (5%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 764
            V RE I  ++   + K +  D KK L V F GE+ +D GGV +E+  L+  E+L+P YG+
Sbjct: 377  VSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGL 436

Query: 765  FRYYEDS--RLIWFSDKTFEDSDL--FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 820
            F+Y  D+   L    D +     L  FH +G I GLA+++   ++  F +  YK+LL K 
Sbjct: 437  FQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKP 496

Query: 821  PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAV 880
              L DL+ + P++ +S+  +L   E+DI       F +    FG     EL  NG +  V
Sbjct: 497  IQLSDLESVDPELHKSLVWIL---ENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPV 553

Query: 881  NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYD 940
             ++N++E+V  YV++ F + + + F A   GF+++    +L  F   EL+ ++ G    D
Sbjct: 554  TEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKID 613

Query: 941  WKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLK-- 998
              + + NT  K    A+   ++ FW+       E++ + L F+TGS R+P+ G K+L+  
Sbjct: 614  LNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGS 672

Query: 999  --------LVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1048
                      I       + LP +HTCFN +D+P Y   E L  KL+ A++   GF++
Sbjct: 673  TGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 730


>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
          Length = 862

 Score =  172 bits (437), Expect = 1e-42
 Identities = 108/356 (30%), Positives = 185/356 (51%), Gaps = 17/356 (4%)

Query: 703  LVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKY 762
            + V R+ +  D+ + +      D ++ L VIF GE+ +D GGV +E+F L+  E+L+P Y
Sbjct: 509  ITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMY 568

Query: 763  GMFRYY-EDSRLIWFSDKTFEDSD---LFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
             +F Y  +D+  +  +  ++ + D    F  IG    +A+++   +D  F L  YK++L 
Sbjct: 569  CLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILN 628

Query: 819  KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFC-LNFTITVENFGATEVKELVLNGAD 877
            K   L DL+ + P+   S   L+   E++IEE    + F++  E  G  +  +L  NG +
Sbjct: 629  KPVGLKDLESIDPEFYNS---LIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGN 685

Query: 878  TAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNT 937
              V ++N++E++    ++  ++ V     AF  GF+++   + L  F   EL+ ++ G  
Sbjct: 686  ILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQ 745

Query: 938  NYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL 997
              D  + +++  Y+  Y      I  FW+   E+  EK+ + L F+TG+ R+P+ G   L
Sbjct: 746  EIDLNDWQRHAIYR-HYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADL 804

Query: 998  -------KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
                   K  I+  G  E +LP SHTCFN LDLP Y   E L+ KL+ AI+  EGF
Sbjct: 805  MGSNGPQKFCIEKVGK-ENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859


>gi|114520609 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 1 [Homo sapiens]
          Length = 900

 Score =  170 bits (431), Expect = 6e-42
 Identities = 106/354 (29%), Positives = 181/354 (51%), Gaps = 16/354 (4%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763
            +RR  ++ D+   +   K  D+ K  L + F GE  +D GGV +E+F LI +E+ +P YG
Sbjct: 547  LRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYG 606

Query: 764  MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
            +F Y   D+  +  +  +     +    F  IG + G+A+Y+  ++D  F    YK +L 
Sbjct: 607  LFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLH 666

Query: 819  KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878
            K  +L D++ +  +   S++ +L+    +++    L F I  E FG T   EL   G++ 
Sbjct: 667  KPITLHDMESVDSEYYNSLRWILENDPTELD----LRFIIDEELFGQTHQHELKNGGSEI 722

Query: 879  AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938
             V  +N++E++   + + F   +     AF  GF ++    ++ +F  NEL+ ++ G  +
Sbjct: 723  VVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGD 782

Query: 939  YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997
             D  +  ++T+YK  Y A H  I+ FW+    +  EK+ + L F+TG+ R+P+ G   L 
Sbjct: 783  VDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELY 842

Query: 998  -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
                 +       G  E LP +HTCFN LDLP Y   E L  KL  AI++ +GF
Sbjct: 843  GSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 896


>gi|114520607 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 2 [Homo sapiens]
          Length = 1247

 Score =  170 bits (431), Expect = 6e-42
 Identities = 106/354 (29%), Positives = 181/354 (51%), Gaps = 16/354 (4%)

Query: 705  VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763
            +RR  ++ D+   +   K  D+ K  L + F GE  +D GGV +E+F LI +E+ +P YG
Sbjct: 894  LRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYG 953

Query: 764  MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818
            +F Y   D+  +  +  +     +    F  IG + G+A+Y+  ++D  F    YK +L 
Sbjct: 954  LFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLH 1013

Query: 819  KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878
            K  +L D++ +  +   S++ +L+    +++    L F I  E FG T   EL   G++ 
Sbjct: 1014 KPITLHDMESVDSEYYNSLRWILENDPTELD----LRFIIDEELFGQTHQHELKNGGSEI 1069

Query: 879  AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938
             V  +N++E++   + + F   +     AF  GF ++    ++ +F  NEL+ ++ G  +
Sbjct: 1070 VVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGD 1129

Query: 939  YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997
             D  +  ++T+YK  Y A H  I+ FW+    +  EK+ + L F+TG+ R+P+ G   L 
Sbjct: 1130 VDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELY 1189

Query: 998  -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046
                 +       G  E LP +HTCFN LDLP Y   E L  KL  AI++ +GF
Sbjct: 1190 GSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243


>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
          Length = 4861

 Score =  170 bits (430), Expect = 7e-42
 Identities = 110/346 (31%), Positives = 176/346 (50%), Gaps = 14/346 (4%)

Query: 4    WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
            WG    GQL   G +   V+ P  +  F   + + V CG   T  +  +GTV  CG    
Sbjct: 4002 WGAGRHGQLAEAGRN---VMVPAAAPSF--SQAQQVICGQNCTFVIQANGTVLACGEGSY 4056

Query: 64   GQLGHEKSRKKPEQVVALDAQNIVAV----SCG-EAHTLALNDKGQVYAWGLDSDGQLGL 118
            G+LG   S       V    Q  V      SCG + H++AL + G+V++WG    G+LG 
Sbjct: 4057 GRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGH 4116

Query: 119  VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQ 178
             G+ +  R PR I++L   ++VQ++CG+ HS  ++   ++F +G   YG+LGLG    K+
Sbjct: 4117 -GNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKK 4175

Query: 179  TSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGA-IFGWGRNKFGQLGLNDENDRYVPNLLK 237
              P+ + +L G    QVA G  H+  ++  G+ ++ +G   +G+LGL +   +  P  + 
Sbjct: 4176 L-PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKID 4234

Query: 238  SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVT 297
             L    I  + CG   + ALTK+G V+TFG      L      +   P+++  L G I+ 
Sbjct: 4235 VLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIE 4294

Query: 298  EIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343
            ++A G +HT A   S+G +Y++G    GQLG G T++ + P  V G
Sbjct: 4295 DVAVGAEHTLALA-SNGDVYAWGSNSEGQLGLGHTNHVREPTLVTG 4339



 Score =  161 bits (407), Expect = 3e-39
 Identities = 104/314 (33%), Positives = 164/314 (52%), Gaps = 8/314 (2%)

Query: 1    MLCWGNASFGQLGLGGIDEEIVLEPRKS--DFFINKRVRDVGCGLRHTVFVLDDGTVYTC 58
            +L  G  S+G+LG G  D+  VL    +   F + + V   G    H++ + + G V++ 
Sbjct: 4048 VLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSD-GHSMALTESGEVFSW 4106

Query: 59   GCNDLGQLGHEKS--RKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQL 116
            G  D G+LGH  S  +++P Q+ AL  + +V +SCG  H+  +   G+++ +G    G+L
Sbjct: 4107 GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL 4166

Query: 117  GLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSK-ASEVFCWGQNKYGQLGLGTDC 175
            GL G+    ++P  + +L   QI QVACG  H+LA+S   S V+ +G   YG+LGLG   
Sbjct: 4167 GL-GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNST 4225

Query: 176  KKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNL 235
             K +SPQ +  L GI   +VA G   S  LT  G ++ +G+++   L      +   P  
Sbjct: 4226 AK-SSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQ 4284

Query: 236  LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295
            +  L    I  +  G +HT AL   G V+ +G+   GQLG   T+H   P  V  L G  
Sbjct: 4285 IPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKN 4344

Query: 296  VTEIACGRQHTSAF 309
            V +I+ GR H++A+
Sbjct: 4345 VRQISAGRCHSAAW 4358



 Score =  148 bits (373), Expect = 3e-35
 Identities = 91/258 (35%), Positives = 136/258 (52%), Gaps = 7/258 (2%)

Query: 4    WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
            WG+  +G+LG G  D +    PR+ +    + V  + CG +H+  V  DG ++T G  D 
Sbjct: 4106 WGDGDYGKLGHGNSDRQ--RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 4163

Query: 64   GQLG--HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALN-DKGQVYAWGLDSDGQLGLVG 120
            G+LG  +  ++K PE+V AL+   I  V+CG  HTLA++ D   V+A+G    G+LGL G
Sbjct: 4164 GRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGL-G 4222

Query: 121  SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180
            +      P+ I  L  I I +VACG   S+AL+K   V+ +GQ++   L  G   +    
Sbjct: 4223 NSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGR-ARNHNR 4281

Query: 181  PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240
            PQ +  L G+    VA G  H+  L  +G ++ WG N  GQLGL   N    P L+  L+
Sbjct: 4282 PQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQ 4341

Query: 241  SQKIVYICCGEDHTAALT 258
             + +  I  G  H+AA T
Sbjct: 4342 GKNVRQISAGRCHSAAWT 4359



 Score =  140 bits (353), Expect = 6e-33
 Identities = 97/313 (30%), Positives = 162/313 (51%), Gaps = 15/313 (4%)

Query: 5   GNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLR---HTVFVLDDGTVYTCGCN 61
           G  S+G+LGLG  + +  L  +K  F  ++ ++ V        HT+    +G V++ G  
Sbjct: 428 GKGSYGRLGLGDSNNQSTL--KKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDG 485

Query: 62  DLGQLGHEKS--RKKPEQVVA-LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118
           D G+LGH  S  +K P+ +   L  + +V VS G  H+ A+ + G++Y WG    G+LG 
Sbjct: 486 DYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG- 544

Query: 119 VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSK-ASEVFCWGQNKYGQLGLGTDCKK 177
            G      +P  +K +S++   +V+CG  H++ALSK    V+ +G    G+LG G D  +
Sbjct: 545 HGDSNSRNIPTLVKDISNVG--EVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHG-DTNR 601

Query: 178 QTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLK 237
              P+++++L G+   +V AG   S  LT +G ++ WG       G + E     P L++
Sbjct: 602 VYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG-SSEATALRPKLIE 660

Query: 238 SLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH-NSTSHEINPRKVFELMGSIV 296
            L + +IV +  G+ H  AL+ +  V+ +G    GQ G  NST     P+KV  L G  +
Sbjct: 661 ELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAI 720

Query: 297 TEIACGRQHTSAF 309
            +I+ G  H+ A+
Sbjct: 721 QQISAGTSHSLAW 733



 Score =  140 bits (352), Expect = 8e-33
 Identities = 80/242 (33%), Positives = 122/242 (50%), Gaps = 6/242 (2%)

Query: 99   LNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEV 158
            L  K  VY WG    GQL   G    + VP    S S  Q  QV CG   +  +     V
Sbjct: 3993 LGGKCDVYLWGAGRHGQLAEAGRN--VMVPAAAPSFSQAQ--QVICGQNCTFVIQANGTV 4048

Query: 159  FCWGQNKYGQLGLGT--DCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGR 216
               G+  YG+LG G   D    T    L+  +    +       HS  LT SG +F WG 
Sbjct: 4049 LACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGD 4108

Query: 217  NKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH 276
              +G+LG  + + +  P  +++L+ +++V + CG  H+A +T +G +FTFG G YG+LG 
Sbjct: 4109 GDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGL 4168

Query: 277  NSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336
             +TS++  P +V  L G  + ++ACG  HT A       +++FG G  G+LG G+++ + 
Sbjct: 4169 GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS 4228

Query: 337  SP 338
            SP
Sbjct: 4229 SP 4230



 Score =  137 bits (344), Expect = 7e-32
 Identities = 99/349 (28%), Positives = 175/349 (50%), Gaps = 20/349 (5%)

Query: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLD-DGTVYTCGCND 62
           WG+ S  QL  G   +E +L+P+ +  F + +  + G   ++  FV+  DG+V  CG   
Sbjct: 377 WGSNSSHQLVEG--TQEKILQPKLAPSFSDAQTIEAG---QYCTFVISTDGSVRACGKGS 431

Query: 63  LGQLG-----HEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117
            G+LG     ++ + KK         + + +    + HTLA   +G+V++WG    G+LG
Sbjct: 432 YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491

Query: 118 LVGSEECIRVPRNIKS-LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCK 176
             G+    + P+ I+  L    +V V+ GY HS A+++  E++ WG+  +G+LG G D  
Sbjct: 492 -HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHG-DSN 549

Query: 177 KQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSG-AIFGWGRNKFGQLGLNDENDRYVPNL 235
            +  P L+K +  +   +V+ G +H+  L+  G  ++ +G    G+LG  D N  Y P +
Sbjct: 550 SRNIPTLVKDISNVG--EVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKV 607

Query: 236 LKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSI 295
           +++L+   I  +C G   + ALT  G V+ +G G     G +S +  + P+ + EL  + 
Sbjct: 608 IEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG-SSEATALRPKLIEELAATR 666

Query: 296 VTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG-STSNRKSPFTVKG 343
           + +++ G  H  A +     +Y++G    GQ G G ST     P  V G
Sbjct: 667 IVDVSIGDSHCLA-LSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSG 714



 Score =  133 bits (335), Expect = 8e-31
 Identities = 91/284 (32%), Positives = 143/284 (50%), Gaps = 14/284 (4%)

Query: 55  VYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDG 114
           VY  G N   QL      K  +  +A    +   +  G+  T  ++  G V A G  S G
Sbjct: 374 VYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYG 433

Query: 115 QLGLVGSEECIRVPRNI----KSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170
           +LGL  S     + +      +S+  +   + + G  H+LA +   EVF WG   YG+LG
Sbjct: 434 RLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDG--HTLAFTTEGEVFSWGDGDYGKLG 491

Query: 171 LGTDCKKQTSPQLLKS-LLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229
            G +   Q  P+L++  L G   + V+AG  HS  +T  G ++ WG   FG+LG  D N 
Sbjct: 492 HG-NSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNS 550

Query: 230 RYVPNLLKSLRSQKIVYICCGEDHTAALTKEG-GVFTFGAGGYGQLGHNSTSHEINPRKV 288
           R +P L+K +    +  + CG  HT AL+K+G  V++FG G  G+LGH  T+    P+ +
Sbjct: 551 RNIPTLVKDI--SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVI 608

Query: 289 FELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST 332
             L G  + ++  G Q +S  + S+G++Y++G G    LG GS+
Sbjct: 609 EALQGMFIRKVCAGSQ-SSLALTSTGQVYAWGCG--ACLGCGSS 649



 Score =  127 bits (320), Expect = 4e-29
 Identities = 78/246 (31%), Positives = 126/246 (51%), Gaps = 16/246 (6%)

Query: 104 QVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQ 163
           +VY WG +S  QL + G++E I  P+   S SD Q ++   G Y +  +S    V   G+
Sbjct: 373 EVYVWGSNSSHQL-VEGTQEKILQPKLAPSFSDAQTIEA--GQYCTFVISTDGSVRACGK 429

Query: 164 NKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVA------AGGAHSFVLTLSGAIFGWGRN 217
             YG+LGLG    + T    LK L   P   +           H+   T  G +F WG  
Sbjct: 430 GSYGRLGLGDSNNQST----LKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDG 485

Query: 218 KFGQLGLNDENDRYVPNLLKS-LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH 276
            +G+LG  + + +  P L++  L+ + +V +  G  H+AA+T++G ++T+G G +G+LGH
Sbjct: 486 DYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGH 545

Query: 277 NSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336
             ++    P  V ++  S V E++CG  HT A       ++SFG G NG+LG G T+   
Sbjct: 546 GDSNSRNIPTLVKDI--SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVY 603

Query: 337 SPFTVK 342
            P  ++
Sbjct: 604 KPKVIE 609



 Score =  119 bits (299), Expect = 1e-26
 Identities = 80/261 (30%), Positives = 124/261 (47%), Gaps = 14/261 (5%)

Query: 4   WGNASFGQLGLGGIDEE----IVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCG 59
           WG+  +G+LG G    +    ++  P +      K V  V  G RH+  V +DG +YT G
Sbjct: 482 WGDGDYGKLGHGNSSTQKYPKLIQGPLQG-----KVVVCVSAGYRHSAAVTEDGELYTWG 536

Query: 60  CNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQ-VYAWGLDSDGQLGL 118
             D G+LGH  S  +    +  D  N+  VSCG +HT+AL+  G+ V+++G   +G+LG 
Sbjct: 537 EGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLG- 595

Query: 119 VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQ 178
            G    +  P+ I++L  + I +V  G   SLAL+   +V+ WG      LG G+     
Sbjct: 596 HGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCG--ACLGCGSSEATA 653

Query: 179 TSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-NDENDRYVPNLLK 237
             P+L++ L     + V+ G +H   L+    ++ WG N  GQ G  N       P  + 
Sbjct: 654 LRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVS 713

Query: 238 SLRSQKIVYICCGEDHTAALT 258
            L    I  I  G  H+ A T
Sbjct: 714 GLDGIAIQQISAGTSHSLAWT 734



 Score =  114 bits (285), Expect = 5e-25
 Identities = 71/225 (31%), Positives = 119/225 (52%), Gaps = 10/225 (4%)

Query: 119  VGSEECIRVPRNIKSLS--DIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCK 176
            V  +E + +  N K ++  D QI+  A        L    +V+ WG  ++GQL      +
Sbjct: 3958 VPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAG--R 4015

Query: 177  KQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLL 236
                P    S       QV  G   +FV+  +G +   G   +G+LG  + +D +V  ++
Sbjct: 4016 NVMVPAAAPSF--SQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVI 4073

Query: 237  KSLRS---QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMG 293
             +L+     ++V  C  + H+ ALT+ G VF++G G YG+LGH ++  +  PR++  L G
Sbjct: 4074 SALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQG 4133

Query: 294  SIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338
              V +++CG +H SA V S G++++FG G  G+LG G+TSN+K P
Sbjct: 4134 EEVVQMSCGFKH-SAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLP 4177



 Score =  103 bits (257), Expect = 8e-22
 Identities = 72/198 (36%), Positives = 108/198 (54%), Gaps = 14/198 (7%)

Query: 152 LSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAI 211
           +S+  EV+ WG N   QL  GT  +K   P+L  S        + AG   +FV++  G++
Sbjct: 368 VSETCEVYVWGSNSSHQLVEGTQ-EKILQPKLAPSFSDA--QTIEAGQYCTFVISTDGSV 424

Query: 212 FGWGRNKFGQLGLNDENDRYVPNLLKSL-----RSQKIVYICCGED-HTAALTKEGGVFT 265
              G+  +G+LGL D N++   + LK L     RS K V    G D HT A T EG VF+
Sbjct: 425 RACGKGSYGRLGLGDSNNQ---STLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFS 481

Query: 266 FGAGGYGQLGHNSTSHEINPRKV-FELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGN 324
           +G G YG+LGH ++S +  P+ +   L G +V  ++ G +H SA V   G +Y++G G  
Sbjct: 482 WGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRH-SAAVTEDGELYTWGEGDF 540

Query: 325 GQLGTGSTSNRKSPFTVK 342
           G+LG G +++R  P  VK
Sbjct: 541 GRLGHGDSNSRNIPTLVK 558



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 83/329 (25%), Positives = 147/329 (44%), Gaps = 22/329 (6%)

Query: 731  KVIFVGEDAVDAGGVRKEFFLLIMRELL---------DPKYGMFRYYEDSRLIWFSDKTF 781
            KV  VGE A DAGGV  +    + +EL           P       Y   R + F+    
Sbjct: 4513 KVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFL-FNPSAC 4571

Query: 782  EDSDL--FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQ 839
             D  L  F  +G++ G+AI     +DLH    ++K+L     +L+DL+E+     +++  
Sbjct: 4572 LDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNS 4631

Query: 840  LLDYPEDDI-EETFCLNFTITVENF----GATEVKELVLNGADTAVNKQNRQEFVDAYVD 894
            +L   +  I EE+F  +  I +++F       ++  ++  G    +   NR+E+V+  ++
Sbjct: 4632 ILHIEDSGITEESF--HEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIE 4689

Query: 895  YIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEY 954
            Y  ++    +  A   G   +    +L L    +L+ MV G      + L+K   Y+ E 
Sbjct: 4690 YRLHEMDRQV-AAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYR-EV 4747

Query: 955  WAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPI-LGMKSLKLVIQSTGGGEEYLPV 1013
              +H  ++ FW    E   E++  F+ F++G  R+P      S +  I       + LP 
Sbjct: 4748 DEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPT 4807

Query: 1014 SHTCFNLLDLPKYTEKETLRSKLIQAIDH 1042
            S TCF  L LP Y+ +  +  +L  AI++
Sbjct: 4808 SQTCFFQLRLPPYSSQLVMAERLRYAINN 4836



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 40/136 (29%), Positives = 67/136 (49%), Gaps = 6/136 (4%)

Query: 211 IFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGG 270
           ++ WG N   QL    +     P L  S    + +    G+  T  ++ +G V   G G 
Sbjct: 374 VYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIE--AGQYCTFVISTDGSVRACGKGS 431

Query: 271 YGQLGHNSTSHEINPRKV-FELMGSI--VTEIACGRQHTSAFVPSSGRIYSFGLGGNGQL 327
           YG+LG   ++++   +K+ FE   SI  V+       HT AF  + G ++S+G G  G+L
Sbjct: 432 YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFT-TEGEVFSWGDGDYGKL 490

Query: 328 GTGSTSNRKSPFTVKG 343
           G G++S +K P  ++G
Sbjct: 491 GHGNSSTQKYPKLIQG 506


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,032,056
Number of Sequences: 37866
Number of extensions: 1840541
Number of successful extensions: 4739
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 3483
Number of HSP's gapped (non-prelim): 265
length of query: 1049
length of database: 18,247,518
effective HSP length: 113
effective length of query: 936
effective length of database: 13,968,660
effective search space: 13074665760
effective search space used: 13074665760
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.