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Search of human proteins with 35493959
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]
(1068 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|35493952 ubiquitin protein ligase E3B [Homo sapiens] 2147 0.0
gi|35493959 ubiquitin protein ligase E3B [Homo sapiens] 2147 0.0
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 345 1e-94
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 189 2e-47
gi|114520609 neural precursor cell expressed, developmentally do... 183 7e-46
gi|114520607 neural precursor cell expressed, developmentally do... 183 7e-46
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 182 1e-45
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 182 2e-45
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 177 4e-44
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 176 8e-44
gi|222352183 neural precursor cell expressed, developmentally do... 173 9e-43
gi|21361472 neural precursor cell expressed, developmentally dow... 173 9e-43
gi|222352094 neural precursor cell expressed, developmentally do... 173 9e-43
gi|222352092 neural precursor cell expressed, developmentally do... 173 9e-43
gi|222352090 neural precursor cell expressed, developmentally do... 173 9e-43
gi|222352088 neural precursor cell expressed, developmentally do... 173 9e-43
gi|222352086 neural precursor cell expressed, developmentally do... 173 9e-43
gi|222352084 neural precursor cell expressed, developmentally do... 173 9e-43
gi|222352082 neural precursor cell expressed, developmentally do... 173 9e-43
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 172 1e-42
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 172 1e-42
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 171 4e-42
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 161 3e-39
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 161 3e-39
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 159 1e-38
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 159 1e-38
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 159 1e-38
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 155 3e-37
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 146 1e-34
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 127 4e-29
>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 2147 bits (5563), Expect = 0.0
Identities = 1068/1068 (100%), Positives = 1068/1068 (100%)
Query: 1 MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDF 60
MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDF
Sbjct: 1 MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDF 60
Query: 61 FKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSL 120
FKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSL
Sbjct: 61 FKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSL 120
Query: 121 ACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRG 180
ACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRG
Sbjct: 121 ACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRG 180
Query: 181 KGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPV 240
KGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPV
Sbjct: 181 KGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPV 240
Query: 241 IAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV 300
IAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV
Sbjct: 241 IAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV 300
Query: 301 CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWH 360
CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWH
Sbjct: 301 CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWH 360
Query: 361 PVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASP 420
PVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASP
Sbjct: 361 PVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASP 420
Query: 421 QNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQ 480
QNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQ
Sbjct: 421 QNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQ 480
Query: 481 ILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLI 540
ILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLI
Sbjct: 481 ILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLI 540
Query: 541 TILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV 600
TILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV
Sbjct: 541 TILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV 600
Query: 601 LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM 660
LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM
Sbjct: 601 LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM 660
Query: 661 VTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGV 720
VTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGV
Sbjct: 661 VTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGV 720
Query: 721 DEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK 780
DEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK
Sbjct: 721 DEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK 780
Query: 781 MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI 840
MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI
Sbjct: 781 MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI 840
Query: 841 TDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI 900
TDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI
Sbjct: 841 TDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI 900
Query: 901 SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDIL 960
SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDIL
Sbjct: 901 SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDIL 960
Query: 961 ASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFT 1020
ASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFT
Sbjct: 961 ASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFT 1020
Query: 1021 IRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1068
IRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS
Sbjct: 1021 IRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1068
>gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 2147 bits (5563), Expect = 0.0
Identities = 1068/1068 (100%), Positives = 1068/1068 (100%)
Query: 1 MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDF 60
MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDF
Sbjct: 1 MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDF 60
Query: 61 FKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSL 120
FKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSL
Sbjct: 61 FKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSL 120
Query: 121 ACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRG 180
ACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRG
Sbjct: 121 ACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRG 180
Query: 181 KGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPV 240
KGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPV
Sbjct: 181 KGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPV 240
Query: 241 IAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV 300
IAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV
Sbjct: 241 IAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV 300
Query: 301 CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWH 360
CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWH
Sbjct: 301 CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWH 360
Query: 361 PVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASP 420
PVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASP
Sbjct: 361 PVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASP 420
Query: 421 QNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQ 480
QNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQ
Sbjct: 421 QNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQ 480
Query: 481 ILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLI 540
ILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLI
Sbjct: 481 ILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLI 540
Query: 541 TILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV 600
TILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV
Sbjct: 541 TILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV 600
Query: 601 LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM 660
LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM
Sbjct: 601 LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM 660
Query: 661 VTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGV 720
VTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGV
Sbjct: 661 VTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGV 720
Query: 721 DEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK 780
DEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK
Sbjct: 721 DEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK 780
Query: 781 MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI 840
MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI
Sbjct: 781 MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI 840
Query: 841 TDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI 900
TDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI
Sbjct: 841 TDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI 900
Query: 901 SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDIL 960
SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDIL
Sbjct: 901 SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDIL 960
Query: 961 ASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFT 1020
ASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFT
Sbjct: 961 ASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFT 1020
Query: 1021 IRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1068
IRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS
Sbjct: 1021 IRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1068
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 345 bits (886), Expect = 1e-94
Identities = 319/1163 (27%), Positives = 513/1163 (44%), Gaps = 207/1163 (17%)
Query: 9 RAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDD--------- 59
+A + R ++ R +R ++ R + A++IQ+ +R + R + Q I+R D
Sbjct: 25 KASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYRDRKQ-QYSIQRSAFDRCATLSQSG 83
Query: 60 --FFKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWY 117
F A+ P T + R+LLF ++ ED++R L ++++ ++
Sbjct: 84 GAFPIANGPNLTL--------LVRQLLFFYKQNEDSKRLIWLYQNLI------KHSSLFV 129
Query: 118 VSLACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTW-K 176
L S+ LT L+ QIK ++ CC L+ DS + L + ML F+ +T+
Sbjct: 130 KQLDGSERLTCLF--QIKRLMSLCCRLLQNCN----DDSLNVALPMRMLEVFSSENTYLP 183
Query: 177 ILRGKGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLA 236
+L+ + + I+ ++ +G+Y L +L+ SK + +S
Sbjct: 184 VLQDASYVV-----SVIEQILHYMIHNGYYRSLYLLIN----------SKLPSSIEYSDL 228
Query: 237 LRPVIAAQFSDNLIRPFLIHIMSVP-ALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQD 295
R IA +N+++P S P + T E D + FII
Sbjct: 229 SRVPIAKILLENVLKPLHFTYNSCPEGARQQVFTAFTEEFLAAPFTDQIFHFII------ 282
Query: 296 RCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVS--QKK 353
+L T+ L+ L ++ G L L Y+ ++
Sbjct: 283 ------PALADAQTVFPYEPFLNALLLIESRCSRKSGGAPWLFYFVLTVGENYLGALSEE 336
Query: 354 SNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPA 413
L + + + SQ + S H D S ES+E
Sbjct: 337 GLLVYLRVLQTFLSQLPVSPASASCH--------------------DSASDSEEESEEA- 375
Query: 414 HAQPASPQN-VLPVKSLLKRAFQK---SASVRNILRPVGGKRVDSAEVQKVCNIC-VLYQ 468
+P+SP++ L V + + +K +L V + ++C L
Sbjct: 376 -DKPSSPEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMV 434
Query: 469 TSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPH---GGLKLFLECLNNDT----EE 521
+ ++RL L L + L LW I + G + L+ ++ + E+
Sbjct: 435 QHRMMVPKVRL--LYSLAFNARFLRHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFED 492
Query: 522 SKQLLAMLMLFCDCSRHLITILDDIEVYEEQIS-----------FKLEELVTISSFLNSF 570
S +++ + LF H + + D E + + I F LEEL+ +S L
Sbjct: 493 SSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELIMLSRCLRDA 552
Query: 571 ---VFKMIWDGIVENAKGETLELFQSV----------------HGWLM----------VL 601
+ K+ + + E + FQS+ W+ +L
Sbjct: 553 CLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKML 612
Query: 602 YERDCRRRFTPEDHWL--RKDLKPSVLFQ------------------------------- 628
RD RR F P +HWL ++D+K + Q
Sbjct: 613 KSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLES 672
Query: 629 -ELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRR 687
L +R +L +P V+P + RV +F+ ++ +K++ V+ ++TIRR
Sbjct: 673 PPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQE---VQGDGPFLDGINVTIRR 729
Query: 688 SRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPAL 747
+ + ED Y++L ++ +K IRV +N G+DEAGID G+F+EFL E++K F+P
Sbjct: 730 NYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQ 789
Query: 748 NLFKTTSGDERLYPSPTS--YIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLL 805
FKTT+ + LYP+P + + +++ + + F+G+MLGKA+YE ++V++PFA FFLS+LL
Sbjct: 790 GFFKTTN-EGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLL 848
Query: 806 GHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPG 865
G V + L SLD E YKNL +K Y+ D+ +LGL + + +G+ EL G
Sbjct: 849 GTSADV---DIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFG 905
Query: 866 GKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLIS 925
GK IPVT+ N+I+YIHL+A +R++ QI+ A G +++ EW+RMF E+Q LIS
Sbjct: 906 GKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLIS 965
Query: 926 GDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLL 985
G I LEDLK T Y GG+ H VI W ++ FT +E+ LKFVTSCSRPPLL
Sbjct: 966 GAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVV-EGFTDEEKRKLLKFVTSCSRPPLL 1024
Query: 986 GFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNY 1045
GF L P F I GS L RLPT+STC NLLKLP +
Sbjct: 1025 GFKELYPAFCIH------------NGGSDLE------------RLPTASTCMNLLKLPEF 1060
Query: 1046 SKKSVLREKLRYAISMNTGFELS 1068
+++LR KL YAI GFELS
Sbjct: 1061 YDETLLRSKLLYAIECAAGFELS 1083
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 189 bits (479), Expect = 2e-47
Identities = 134/390 (34%), Positives = 200/390 (51%), Gaps = 38/390 (9%)
Query: 683 ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRV 742
+ +RR + ED Y +L + S MK + + F E G D G+ +E+ I + +
Sbjct: 4019 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEG-----EEGQDAGGLLREWYMIISREM 4073
Query: 743 FDPALNLFKTTSGDERLYP-SPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFL 801
F+P LF+T+ GD Y +P+S+ + N+L F+FVG+++ KAVY+ +++ F F
Sbjct: 4074 FNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFY 4133
Query: 802 SQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCH- 860
+LG SV Y+ ++ S D FY+ L + + D++ LG L++ +V VC
Sbjct: 4134 KHILGK--SVRYTDME---SEDYHFYQGLVYL--LENDVSTLGYDLTFSTEVQEFGVCEV 4186
Query: 861 -ELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPE 919
+L P G I VT ENK Y+HL+ RM I+ Q AA + GF II I +F+ E
Sbjct: 4187 RDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQE 4246
Query: 920 LQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSC 979
L+ LISG ID++DLK +T Y+ + + I W W L S F +RA FL+FVT
Sbjct: 4247 LELLISG-LPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRS-FDQADRAKFLQFVTGT 4303
Query: 980 SRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNL 1039
S+ PL GFA L+ I+ ++ D + D RLP++ TCFN
Sbjct: 4304 SKVPLQGFAALEGMNGIQKFQIHRDDRSTD-------------------RLPSAHTCFNQ 4344
Query: 1040 LKLPNYSKKSVLREKLRYAI-SMNTGFELS 1068
L LP Y LR L AI + GF L+
Sbjct: 4345 LDLPAYESFEKLRHMLLLAIQECSEGFGLA 4374
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 183 bits (465), Expect = 7e-46
Identities = 134/427 (31%), Positives = 218/427 (51%), Gaps = 49/427 (11%)
Query: 644 IPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQ 703
+P+ +K + FR + K+ + P+ + +RR+ +LED Y ++ + +
Sbjct: 516 VPYSRDYKRKYEFFRRKLKKQND----------IPNKFEMKLRRATVLEDSYRRIMGVKR 565
Query: 704 -HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDE-RLYP 761
+K + ++F E G+D GV +E+ I K +F+P LF+ ++ D L
Sbjct: 566 ADFLKARLWIEFDG-----EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQI 620
Query: 762 SPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELP 820
+P S + +E++L F+F+G++ G AVY G ++D F F +L H + ++ ++
Sbjct: 621 NPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML--HKPI---TLHDME 675
Query: 821 SLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYI 880
S+DSE+Y +L I + D T+L L DE++ GQ HEL GG I VTN+NK YI
Sbjct: 676 SVDSEYYNSLRWI--LENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYI 733
Query: 881 HLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHT 940
+L+ +R +I+ Q AA GF +I + I++F EL+ L+ G ++D+ D ++HT
Sbjct: 734 YLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG-LGDVDVNDWREHT 792
Query: 941 VYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCV 999
Y G+ +H+VI W W +L D ++R L+FVT SR P+ GFA L
Sbjct: 793 KYKNGYSANHQVIQWFWKAVLMMD--SEKRIRLLQFVTGTSRVPMNGFAEL--------- 841
Query: 1000 EVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAI 1059
GS FT+ + +LP + TCFN L LP Y L +KL+ AI
Sbjct: 842 -----------YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAI 890
Query: 1060 SMNTGFE 1066
GF+
Sbjct: 891 ENTQGFD 897
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 183 bits (465), Expect = 7e-46
Identities = 134/427 (31%), Positives = 218/427 (51%), Gaps = 49/427 (11%)
Query: 644 IPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQ 703
+P+ +K + FR + K+ + P+ + +RR+ +LED Y ++ + +
Sbjct: 863 VPYSRDYKRKYEFFRRKLKKQND----------IPNKFEMKLRRATVLEDSYRRIMGVKR 912
Query: 704 -HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDE-RLYP 761
+K + ++F E G+D GV +E+ I K +F+P LF+ ++ D L
Sbjct: 913 ADFLKARLWIEFDG-----EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQI 967
Query: 762 SPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELP 820
+P S + +E++L F+F+G++ G AVY G ++D F F +L H + ++ ++
Sbjct: 968 NPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML--HKPI---TLHDME 1022
Query: 821 SLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYI 880
S+DSE+Y +L I + D T+L L DE++ GQ HEL GG I VTN+NK YI
Sbjct: 1023 SVDSEYYNSLRWI--LENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYI 1080
Query: 881 HLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHT 940
+L+ +R +I+ Q AA GF +I + I++F EL+ L+ G ++D+ D ++HT
Sbjct: 1081 YLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG-LGDVDVNDWREHT 1139
Query: 941 VYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCV 999
Y G+ +H+VI W W +L D ++R L+FVT SR P+ GFA L
Sbjct: 1140 KYKNGYSANHQVIQWFWKAVLMMD--SEKRIRLLQFVTGTSRVPMNGFAEL--------- 1188
Query: 1000 EVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAI 1059
GS FT+ + +LP + TCFN L LP Y L +KL+ AI
Sbjct: 1189 -----------YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAI 1237
Query: 1060 SMNTGFE 1066
GF+
Sbjct: 1238 ENTQGFD 1244
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
Length = 862
Score = 182 bits (462), Expect = 1e-45
Identities = 120/391 (30%), Positives = 192/391 (49%), Gaps = 34/391 (8%)
Query: 676 ASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFL 735
A P IT+ R + ED ++Q+ S ++ + V F E G+D GV +E+
Sbjct: 502 AMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPG-----EEGLDYGGVAREWF 556
Query: 736 EEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDV 794
+ V +P LF+ D L +P SYI+ ++L+ F F+G+ + A++ G +D
Sbjct: 557 FLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDT 616
Query: 795 PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
F+ F ++L + +L S+D EFY +L +K + + DL + S D++++
Sbjct: 617 GFSLPFYKRILNKP-----VGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEIL 671
Query: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
G++ H+L P G I VT ENK YI ++A +R+ ++ QT A GF I+ ++++
Sbjct: 672 GEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQY 731
Query: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLK 974
F EL+ L+ G EIDL D ++H + Y + + + I+W W + + ++R L+
Sbjct: 732 FDAKELEVLLCG-MQEIDLNDWQRHAI-YRHYARTSKQIMWFWQFV-KEIDNEKRMRLLQ 788
Query: 975 FVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSS 1034
FVT R P+ GFA D +GS F I K LP S
Sbjct: 789 FVTGTCRLPVGGFA--------------------DLMGSNGPQKFCIEKVGKENWLPRSH 828
Query: 1035 TCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
TCFN L LP Y L+EKL +AI GF
Sbjct: 829 TCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 182 bits (461), Expect = 2e-45
Identities = 131/393 (33%), Positives = 193/393 (49%), Gaps = 37/393 (9%)
Query: 678 PHVTHITIRRSRMLEDGYEQLRQLSQHAM-KGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
P + IRR +LED + Q+ S+ + + + V FV E G+D G +EF
Sbjct: 1213 PGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVG-----EEGLDYSGPSREFFF 1267
Query: 737 EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVP 795
+ + +F+P LF+ ++ D + SP S +N+ + F F G++LG A+ ++D
Sbjct: 1268 LVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAF 1327
Query: 796 FASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITD-LGLTLSYDEDVM 854
F F LL + +L LD EF+++L +K D DI D L LT + +E+V
Sbjct: 1328 FTRPFYKALLR-----ILCDLSDLEYLDEEFHQSLQWMK--DNDIHDILDLTFTVNEEVF 1380
Query: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
GQ+ EL PGG IPVT +NK YI M +R+ + QT +L+ GF ++ + +
Sbjct: 1381 GQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSV 1440
Query: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLK 974
F EL+ +I+G AEIDL D + +T Y GG+H +H VI W W F ++R L+
Sbjct: 1441 FDARELELVIAG-TAEIDLSDWRNNTEYRGGYHDNHIVIRWFW-AAVERFNNEQRLRLLQ 1498
Query: 975 FVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSS 1034
FVT S P GFA L+ GS F + K LP +
Sbjct: 1499 FVTGTSSIPYEGFASLR--------------------GSNGPRRFCVEKWGKITALPRAH 1538
Query: 1035 TCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1067
TCFN L LP Y S+L EKL A+ + F L
Sbjct: 1539 TCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGL 1571
>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
protein ligase 1 [Homo sapiens]
Length = 909
Score = 177 bits (450), Expect = 4e-44
Identities = 121/379 (31%), Positives = 186/379 (49%), Gaps = 36/379 (9%)
Query: 683 ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRV 742
+ + R + E + + + +K I V+F + G+ + GV +E+ + + +
Sbjct: 555 LLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQ------GVVREWFDILSNEI 608
Query: 743 FDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLS 802
+P LF ++ P+ SY++ ++L F F G++LG A+ +V++ F F
Sbjct: 609 VNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYK 668
Query: 803 QLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLG--LTLSYDEDVMGQLVCH 860
+LG + ++ S+D E+ KNL I D DI+DLG LT S + DV G +
Sbjct: 669 HILG-----IPVNYQDVASIDPEYAKNLQWI--LDNDISDLGLELTFSVETDVFGAMEEV 721
Query: 861 ELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPEL 920
L PGG +I VT NK Y+ L+ RM I+ Q A + GF I P I++F EL
Sbjct: 722 PLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYEL 781
Query: 921 QRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCS 980
+ L+SG EID+ D K+T Y G+ VI W W+++ D T +ER + L+FVT S
Sbjct: 782 ELLLSG-MPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVV-EDITQEERVLLLQFVTGSS 839
Query: 981 RPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLL 1040
R P GFA + GS L+ F LPTSSTC N+L
Sbjct: 840 RVPHGGFANIMG-------------------GSGLQNFTIAAVPYTPNLLPTSSTCINML 880
Query: 1041 KLPNYSKKSVLREKLRYAI 1059
KLP Y K +L+++L A+
Sbjct: 881 KLPEYPSKEILKDRLLVAL 899
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 176 bits (447), Expect = 8e-44
Identities = 130/393 (33%), Positives = 190/393 (48%), Gaps = 37/393 (9%)
Query: 678 PHVTHITIRRSRMLEDGYEQLRQLSQHAM-KGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
P + IRR +LE + Q+ S+ + + + V FV E G+D G +EF
Sbjct: 1247 PGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVG-----EEGLDYSGPSREFFF 1301
Query: 737 EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVP 795
+ + +F+P LF+ ++ D + SP S EN+L+ F F G++LG A+ ++D
Sbjct: 1302 LLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAF 1361
Query: 796 FASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITD-LGLTLSYDEDVM 854
F F LL + +L LD EF+++L +K D +ITD L LT + +E+V
Sbjct: 1362 FTRPFYKALLR-----LPCDLSDLEYLDEEFHQSLQWMK--DNNITDILDLTFTVNEEVF 1414
Query: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
GQ+ EL GG VT +NK YI M +R+ + QT AL+ GF ++ + +
Sbjct: 1415 GQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSV 1474
Query: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLK 974
F EL+ +I+G AEIDL D + +T Y GG+H H VI W W F ++R L+
Sbjct: 1475 FDARELELVIAG-TAEIDLNDWRNNTEYRGGYHDGHLVIRWFW-AAVERFNNEQRLRLLQ 1532
Query: 975 FVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSS 1034
FVT S P GFA L+ +R F I K LP +
Sbjct: 1533 FVTGTSSVPYEGFAALRGSNGLR--------------------RFCIEKWGKITSLPRAH 1572
Query: 1035 TCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1067
TCFN L LP Y S+L EKL A+ + F L
Sbjct: 1573 TCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGL 1605
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 173 bits (438), Expect = 9e-43
Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)
Query: 678 PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
P+ + + R+ + E+ Y ++ + + +K + ++F + E G+D GV +E+
Sbjct: 494 PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 548
Query: 737 EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
+ K +F+P LF+ ++ D L +P S + +E++L F F+G++ G AV+ G ++D
Sbjct: 549 LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 608
Query: 795 PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
F F +LG +++++ S+DSE+Y +L I + D T+L L DE+
Sbjct: 609 FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 661
Query: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
GQ +L P G I VTNENK YI L+ +R +++ Q A + GF ++ + I++
Sbjct: 662 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 721
Query: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
F EL+ L+ G ++D+ D ++H++Y G+ +H VI W W +L D ++R L
Sbjct: 722 FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 778
Query: 974 KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
+FVT SR P+ GFA L GS FTI + +LP +
Sbjct: 779 QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 818
Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
TCFN L LP Y LREKL A+ GFE
Sbjct: 819 HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 851
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 173 bits (438), Expect = 9e-43
Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)
Query: 678 PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
P+ + + R+ + E+ Y ++ + + +K + ++F + E G+D GV +E+
Sbjct: 595 PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 649
Query: 737 EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
+ K +F+P LF+ ++ D L +P S + +E++L F F+G++ G AV+ G ++D
Sbjct: 650 LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 709
Query: 795 PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
F F +LG +++++ S+DSE+Y +L I + D T+L L DE+
Sbjct: 710 FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 762
Query: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
GQ +L P G I VTNENK YI L+ +R +++ Q A + GF ++ + I++
Sbjct: 763 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 822
Query: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
F EL+ L+ G ++D+ D ++H++Y G+ +H VI W W +L D ++R L
Sbjct: 823 FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 879
Query: 974 KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
+FVT SR P+ GFA L GS FTI + +LP +
Sbjct: 880 QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 919
Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
TCFN L LP Y LREKL A+ GFE
Sbjct: 920 HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 952
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 173 bits (438), Expect = 9e-43
Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)
Query: 678 PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
P+ + + R+ + E+ Y ++ + + +K + ++F + E G+D GV +E+
Sbjct: 474 PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 528
Query: 737 EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
+ K +F+P LF+ ++ D L +P S + +E++L F F+G++ G AV+ G ++D
Sbjct: 529 LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 588
Query: 795 PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
F F +LG +++++ S+DSE+Y +L I + D T+L L DE+
Sbjct: 589 FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 641
Query: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
GQ +L P G I VTNENK YI L+ +R +++ Q A + GF ++ + I++
Sbjct: 642 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 701
Query: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
F EL+ L+ G ++D+ D ++H++Y G+ +H VI W W +L D ++R L
Sbjct: 702 FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 758
Query: 974 KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
+FVT SR P+ GFA L GS FTI + +LP +
Sbjct: 759 QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 798
Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
TCFN L LP Y LREKL A+ GFE
Sbjct: 799 HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 831
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 173 bits (438), Expect = 9e-43
Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)
Query: 678 PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
P+ + + R+ + E+ Y ++ + + +K + ++F + E G+D GV +E+
Sbjct: 474 PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 528
Query: 737 EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
+ K +F+P LF+ ++ D L +P S + +E++L F F+G++ G AV+ G ++D
Sbjct: 529 LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 588
Query: 795 PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
F F +LG +++++ S+DSE+Y +L I + D T+L L DE+
Sbjct: 589 FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 641
Query: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
GQ +L P G I VTNENK YI L+ +R +++ Q A + GF ++ + I++
Sbjct: 642 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 701
Query: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
F EL+ L+ G ++D+ D ++H++Y G+ +H VI W W +L D ++R L
Sbjct: 702 FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 758
Query: 974 KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
+FVT SR P+ GFA L GS FTI + +LP +
Sbjct: 759 QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 798
Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
TCFN L LP Y LREKL A+ GFE
Sbjct: 799 HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 831
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 173 bits (438), Expect = 9e-43
Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)
Query: 678 PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
P+ + + R+ + E+ Y ++ + + +K + ++F + E G+D GV +E+
Sbjct: 587 PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 641
Query: 737 EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
+ K +F+P LF+ ++ D L +P S + +E++L F F+G++ G AV+ G ++D
Sbjct: 642 LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 701
Query: 795 PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
F F +LG +++++ S+DSE+Y +L I + D T+L L DE+
Sbjct: 702 FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 754
Query: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
GQ +L P G I VTNENK YI L+ +R +++ Q A + GF ++ + I++
Sbjct: 755 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 814
Query: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
F EL+ L+ G ++D+ D ++H++Y G+ +H VI W W +L D ++R L
Sbjct: 815 FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 871
Query: 974 KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
+FVT SR P+ GFA L GS FTI + +LP +
Sbjct: 872 QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 911
Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
TCFN L LP Y LREKL A+ GFE
Sbjct: 912 HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 944
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 173 bits (438), Expect = 9e-43
Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)
Query: 678 PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
P+ + + R+ + E+ Y ++ + + +K + ++F + E G+D GV +E+
Sbjct: 607 PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 661
Query: 737 EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
+ K +F+P LF+ ++ D L +P S + +E++L F F+G++ G AV+ G ++D
Sbjct: 662 LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 721
Query: 795 PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
F F +LG +++++ S+DSE+Y +L I + D T+L L DE+
Sbjct: 722 FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 774
Query: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
GQ +L P G I VTNENK YI L+ +R +++ Q A + GF ++ + I++
Sbjct: 775 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 834
Query: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
F EL+ L+ G ++D+ D ++H++Y G+ +H VI W W +L D ++R L
Sbjct: 835 FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 891
Query: 974 KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
+FVT SR P+ GFA L GS FTI + +LP +
Sbjct: 892 QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 931
Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
TCFN L LP Y LREKL A+ GFE
Sbjct: 932 HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 964
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 173 bits (438), Expect = 9e-43
Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)
Query: 678 PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
P+ + + R+ + E+ Y ++ + + +K + ++F + E G+D GV +E+
Sbjct: 615 PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 669
Query: 737 EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
+ K +F+P LF+ ++ D L +P S + +E++L F F+G++ G AV+ G ++D
Sbjct: 670 LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 729
Query: 795 PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
F F +LG +++++ S+DSE+Y +L I + D T+L L DE+
Sbjct: 730 FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 782
Query: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
GQ +L P G I VTNENK YI L+ +R +++ Q A + GF ++ + I++
Sbjct: 783 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 842
Query: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
F EL+ L+ G ++D+ D ++H++Y G+ +H VI W W +L D ++R L
Sbjct: 843 FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 899
Query: 974 KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
+FVT SR P+ GFA L GS FTI + +LP +
Sbjct: 900 QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 939
Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
TCFN L LP Y LREKL A+ GFE
Sbjct: 940 HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 972
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 173 bits (438), Expect = 9e-43
Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)
Query: 678 PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
P+ + + R+ + E+ Y ++ + + +K + ++F + E G+D GV +E+
Sbjct: 494 PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 548
Query: 737 EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
+ K +F+P LF+ ++ D L +P S + +E++L F F+G++ G AV+ G ++D
Sbjct: 549 LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 608
Query: 795 PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
F F +LG +++++ S+DSE+Y +L I + D T+L L DE+
Sbjct: 609 FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 661
Query: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
GQ +L P G I VTNENK YI L+ +R +++ Q A + GF ++ + I++
Sbjct: 662 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 721
Query: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
F EL+ L+ G ++D+ D ++H++Y G+ +H VI W W +L D ++R L
Sbjct: 722 FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 778
Query: 974 KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
+FVT SR P+ GFA L GS FTI + +LP +
Sbjct: 779 QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 818
Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
TCFN L LP Y LREKL A+ GFE
Sbjct: 819 HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 851
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 173 bits (438), Expect = 9e-43
Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)
Query: 678 PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
P+ + + R+ + E+ Y ++ + + +K + ++F + E G+D GV +E+
Sbjct: 494 PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 548
Query: 737 EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
+ K +F+P LF+ ++ D L +P S + +E++L F F+G++ G AV+ G ++D
Sbjct: 549 LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 608
Query: 795 PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
F F +LG +++++ S+DSE+Y +L I + D T+L L DE+
Sbjct: 609 FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 661
Query: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
GQ +L P G I VTNENK YI L+ +R +++ Q A + GF ++ + I++
Sbjct: 662 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 721
Query: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
F EL+ L+ G ++D+ D ++H++Y G+ +H VI W W +L D ++R L
Sbjct: 722 FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 778
Query: 974 KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
+FVT SR P+ GFA L GS FTI + +LP +
Sbjct: 779 QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 818
Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
TCFN L LP Y LREKL A+ GFE
Sbjct: 819 HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 851
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 172 bits (437), Expect = 1e-42
Identities = 118/393 (30%), Positives = 190/393 (48%), Gaps = 34/393 (8%)
Query: 674 SSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKE 733
S+A P I++ R + ED ++Q+ + + ++ + + + E G+D G+ +E
Sbjct: 69 SNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYI-----IMRGEEGLDYGGIARE 123
Query: 734 FLEEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVV 792
+ + V +P LF+ + L +P S I+ ++L F F+G+ + A+Y G +
Sbjct: 124 WFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFI 183
Query: 793 DVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDED 852
D F F ++L ++ +L S+D EFY ++ IK + + L L D +
Sbjct: 184 DTGFTLPFYKRMLNKR-----PTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDME 238
Query: 853 VMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWI 912
++G++ HEL GG++I VT ENK YI L+ +R ++ QT A + GF + EW+
Sbjct: 239 ILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWL 298
Query: 913 RMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMF 972
R F EL+ ++ G EID+ D +K T+ Y + + + I W W ++ + ++R
Sbjct: 299 RYFDEKELELMLCG-MQEIDMSDWQKSTI-YRHYTKNSKQIQWFWQVV-KEMDNEKRIRL 355
Query: 973 LKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPT 1032
L+FVT R P+ GFA L +GS F I K LP
Sbjct: 356 LQFVTGTCRLPVGGFAEL--------------------IGSNGPQKFCIDKVGKETWLPR 395
Query: 1033 SSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
S TCFN L LP Y LREKL YAI GF
Sbjct: 396 SHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 428
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 172 bits (437), Expect = 1e-42
Identities = 118/393 (30%), Positives = 190/393 (48%), Gaps = 34/393 (8%)
Query: 674 SSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKE 733
S+A P I++ R + ED ++Q+ + + ++ + + + E G+D G+ +E
Sbjct: 508 SNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYI-----IMRGEEGLDYGGIARE 562
Query: 734 FLEEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVV 792
+ + V +P LF+ + L +P S I+ ++L F F+G+ + A+Y G +
Sbjct: 563 WFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFI 622
Query: 793 DVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDED 852
D F F ++L ++ +L S+D EFY ++ IK + + L L D +
Sbjct: 623 DTGFTLPFYKRMLNKR-----PTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDME 677
Query: 853 VMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWI 912
++G++ HEL GG++I VT ENK YI L+ +R ++ QT A + GF + EW+
Sbjct: 678 ILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWL 737
Query: 913 RMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMF 972
R F EL+ ++ G EID+ D +K T+ Y + + + I W W ++ + ++R
Sbjct: 738 RYFDEKELELMLCG-MQEIDMSDWQKSTI-YRHYTKNSKQIQWFWQVV-KEMDNEKRIRL 794
Query: 973 LKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPT 1032
L+FVT R P+ GFA L +GS F I K LP
Sbjct: 795 LQFVTGTCRLPVGGFAEL--------------------IGSNGPQKFCIDKVGKETWLPR 834
Query: 1033 SSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
S TCFN L LP Y LREKL YAI GF
Sbjct: 835 SHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 867
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [Homo
sapiens]
Length = 922
Score = 171 bits (432), Expect = 4e-42
Identities = 121/395 (30%), Positives = 194/395 (49%), Gaps = 38/395 (9%)
Query: 674 SSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKE 733
S+A P I + R + ED ++Q+ L + ++ + V F E G+D G+ +E
Sbjct: 560 SNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRG-----EEGLDYGGLARE 614
Query: 734 FLEEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVV 792
+ + V +P LF+ + L +P S I+ ++L F F+G+ + A++ G +
Sbjct: 615 WFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFI 674
Query: 793 DVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTL--SYD 850
D F+ F ++L ++ +L S+D+EFY +L I+ D +I + GL + S D
Sbjct: 675 DTGFSLPFYKRMLSKK-----LTIKDLESIDTEFYNSLIWIR--DNNIEECGLEMYFSVD 727
Query: 851 EDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPE 910
+++G++ H+L GG I VT ENK YI LM +R ++ QT A + GF ++ +
Sbjct: 728 MEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQ 787
Query: 911 WIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERA 970
W++ F EL+ ++ G E+DL D +++TV Y + + + IIW W + + + R
Sbjct: 788 WLQYFDEKELEVMLCG-MQEVDLADWQRNTV-YRHYTRNSKQIIWFWQFV-KETDNEVRM 844
Query: 971 MFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRL 1030
L+FVT R PL GFA L +GS F I K L
Sbjct: 845 RLLQFVTGTCRLPLGGFAEL--------------------MGSNGPQKFCIEKVGKDTWL 884
Query: 1031 PTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
P S TCFN L LP Y L+EKL +AI GF
Sbjct: 885 PRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 161 bits (407), Expect = 3e-39
Identities = 127/407 (31%), Positives = 195/407 (47%), Gaps = 37/407 (9%)
Query: 664 EKEKLGLVETSSASPHVTH--ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVD 721
+K K+ E S P H I + R + E+ Y Q+ ++ +K + VKF
Sbjct: 380 QKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRG----- 434
Query: 722 EAGIDQDGVFKEFLEEIIKRVFDPALNLFK-TTSGDERLYPSPTSYIHENYLQLFEFVGK 780
E G+D GV +E+L + + +P LF+ +T L +P S I+ ++L F FVG+
Sbjct: 435 EEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGR 494
Query: 781 MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI 840
++G AV+ G ++ F F QLLG + +L S+D E +K+L I + DI
Sbjct: 495 IMGLAVFHGHYINGGFTVPFYKQLLGKP-----IQLSDLESVDPELHKSLVWI--LENDI 547
Query: 841 TD-LGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAAL 899
T L T + + G+++ HEL P G+ +PVT ENK Y+ L ++R I+ Q AL
Sbjct: 548 TPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLAL 607
Query: 900 ISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDI 959
GF +I ++ F EL+ +I G + +IDL D K +T S+ ++ W W
Sbjct: 608 QKGFNELIPQHLLKPFDQKELELIIGGLD-KIDLNDWKSNTRLKHCVADSN-IVRWFWQA 665
Query: 960 LASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFF 1019
+ + F + RA L+FVT +R PL GF L+ G T G+ F
Sbjct: 666 VET-FDEERRARLLQFVTGSTRVPLQGFKALQ----------------GST-GAAGPRLF 707
Query: 1020 TIRKREPG-GRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
TI + LP + TCFN + +P Y L EKL A+ GF
Sbjct: 708 TIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 754
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 161 bits (407), Expect = 3e-39
Identities = 127/407 (31%), Positives = 195/407 (47%), Gaps = 37/407 (9%)
Query: 664 EKEKLGLVETSSASPHVTH--ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVD 721
+K K+ E S P H I + R + E+ Y Q+ ++ +K + VKF
Sbjct: 354 QKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRG----- 408
Query: 722 EAGIDQDGVFKEFLEEIIKRVFDPALNLFK-TTSGDERLYPSPTSYIHENYLQLFEFVGK 780
E G+D GV +E+L + + +P LF+ +T L +P S I+ ++L F FVG+
Sbjct: 409 EEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGR 468
Query: 781 MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI 840
++G AV+ G ++ F F QLLG + +L S+D E +K+L I + DI
Sbjct: 469 IMGLAVFHGHYINGGFTVPFYKQLLGKP-----IQLSDLESVDPELHKSLVWI--LENDI 521
Query: 841 TD-LGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAAL 899
T L T + + G+++ HEL P G+ +PVT ENK Y+ L ++R I+ Q AL
Sbjct: 522 TPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLAL 581
Query: 900 ISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDI 959
GF +I ++ F EL+ +I G + +IDL D K +T S+ ++ W W
Sbjct: 582 QKGFNELIPQHLLKPFDQKELELIIGGLD-KIDLNDWKSNTRLKHCVADSN-IVRWFWQA 639
Query: 960 LASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFF 1019
+ + F + RA L+FVT +R PL GF L+ G T G+ F
Sbjct: 640 VET-FDEERRARLLQFVTGSTRVPLQGFKALQ----------------GST-GAAGPRLF 681
Query: 1020 TIRKREPG-GRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
TI + LP + TCFN + +P Y L EKL A+ GF
Sbjct: 682 TIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 159 bits (403), Expect = 1e-38
Identities = 120/475 (25%), Positives = 222/475 (46%), Gaps = 54/475 (11%)
Query: 605 DCRRRFTPEDHWLRKDLKPSV------LFQELDRDRKRAQLILQYIPHVIPHKNRVLLFR 658
DCR+ P + ++ + L + F +++ + K + + +I + + KN L +
Sbjct: 435 DCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVT-KNLGLYYD 493
Query: 659 TMVTKEKEK-----LGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVK 713
+ E+ LV+ +P++ + +RR +++D +L ++ + +
Sbjct: 494 NRIRMYSERRITVLYSLVQGQQLNPYL-RLKVRRDHIIDDALVRLEMIAMENPADLKKQL 552
Query: 714 FVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQ 773
+V G E G+D+ GV KEF + +++ +F+P + +F + + +P+S+ E
Sbjct: 553 YVEFEG--EQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ-- 608
Query: 774 LFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSI 833
F +G +LG A+Y ++DV F +L+G F D P L Y++L +
Sbjct: 609 -FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKK-GTFRDLGDSHPVL----YQSLKDL 662
Query: 834 KRYDGDITD-LGLTLSYDE-DVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQ 891
Y+G++ D + +T + D+ G + ++L G IP+TNEN+ +++L + + ++
Sbjct: 663 LEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKS 722
Query: 892 IKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHR 951
++ Q A GF + ++ PE L+ + +D + L++ T Y GG+
Sbjct: 723 VEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSV 782
Query: 952 VIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTL 1011
+I W+I+ S FT +++ +FL+F T R P+ G LK
Sbjct: 783 LIREFWEIVHS-FTDEQKRLFLQFTTGTDRAPVGGLGKLK-------------------- 821
Query: 1012 GSVLRGFFTIRKREPGG-RLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
I K P RLPTS TCFN+L LP YS K L+E+L AI+ GF
Sbjct: 822 -------MIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 869
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 159 bits (403), Expect = 1e-38
Identities = 120/475 (25%), Positives = 222/475 (46%), Gaps = 54/475 (11%)
Query: 605 DCRRRFTPEDHWLRKDLKPSV------LFQELDRDRKRAQLILQYIPHVIPHKNRVLLFR 658
DCR+ P + ++ + L + F +++ + K + + +I + + KN L +
Sbjct: 415 DCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVT-KNLGLYYD 473
Query: 659 TMVTKEKEK-----LGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVK 713
+ E+ LV+ +P++ + +RR +++D +L ++ + +
Sbjct: 474 NRIRMYSERRITVLYSLVQGQQLNPYL-RLKVRRDHIIDDALVRLEMIAMENPADLKKQL 532
Query: 714 FVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQ 773
+V G E G+D+ GV KEF + +++ +F+P + +F + + +P+S+ E
Sbjct: 533 YVEFEG--EQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ-- 588
Query: 774 LFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSI 833
F +G +LG A+Y ++DV F +L+G F D P L Y++L +
Sbjct: 589 -FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKK-GTFRDLGDSHPVL----YQSLKDL 642
Query: 834 KRYDGDITD-LGLTLSYDE-DVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQ 891
Y+G++ D + +T + D+ G + ++L G IP+TNEN+ +++L + + ++
Sbjct: 643 LEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKS 702
Query: 892 IKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHR 951
++ Q A GF + ++ PE L+ + +D + L++ T Y GG+
Sbjct: 703 VEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSV 762
Query: 952 VIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTL 1011
+I W+I+ S FT +++ +FL+F T R P+ G LK
Sbjct: 763 LIREFWEIVHS-FTDEQKRLFLQFTTGTDRAPVGGLGKLK-------------------- 801
Query: 1012 GSVLRGFFTIRKREPGG-RLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
I K P RLPTS TCFN+L LP YS K L+E+L AI+ GF
Sbjct: 802 -------MIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 849
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 159 bits (403), Expect = 1e-38
Identities = 120/475 (25%), Positives = 222/475 (46%), Gaps = 54/475 (11%)
Query: 605 DCRRRFTPEDHWLRKDLKPSV------LFQELDRDRKRAQLILQYIPHVIPHKNRVLLFR 658
DCR+ P + ++ + L + F +++ + K + + +I + + KN L +
Sbjct: 438 DCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVT-KNLGLYYD 496
Query: 659 TMVTKEKEK-----LGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVK 713
+ E+ LV+ +P++ + +RR +++D +L ++ + +
Sbjct: 497 NRIRMYSERRITVLYSLVQGQQLNPYL-RLKVRRDHIIDDALVRLEMIAMENPADLKKQL 555
Query: 714 FVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQ 773
+V G E G+D+ GV KEF + +++ +F+P + +F + + +P+S+ E
Sbjct: 556 YVEFEG--EQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ-- 611
Query: 774 LFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSI 833
F +G +LG A+Y ++DV F +L+G F D P L Y++L +
Sbjct: 612 -FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKK-GTFRDLGDSHPVL----YQSLKDL 665
Query: 834 KRYDGDITD-LGLTLSYDE-DVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQ 891
Y+G++ D + +T + D+ G + ++L G IP+TNEN+ +++L + + ++
Sbjct: 666 LEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKS 725
Query: 892 IKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHR 951
++ Q A GF + ++ PE L+ + +D + L++ T Y GG+
Sbjct: 726 VEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSV 785
Query: 952 VIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTL 1011
+I W+I+ S FT +++ +FL+F T R P+ G LK
Sbjct: 786 LIREFWEIVHS-FTDEQKRLFLQFTTGTDRAPVGGLGKLK-------------------- 824
Query: 1012 GSVLRGFFTIRKREPGG-RLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
I K P RLPTS TCFN+L LP YS K L+E+L AI+ GF
Sbjct: 825 -------MIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 872
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 155 bits (391), Expect = 3e-37
Identities = 122/407 (29%), Positives = 190/407 (46%), Gaps = 40/407 (9%)
Query: 664 EKEKLGLVETSSASPHVTH--ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVD 721
+K K+ E S P H I + R + E+ Y Q+ ++ + + +KF
Sbjct: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRG----- 428
Query: 722 EAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGD-ERLYPSPTSYIHENYLQLFEFVGK 780
E G+D GV +E+L + + +P LF+ + D L +P S ++ +L F FVG+
Sbjct: 429 EEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGR 488
Query: 781 MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI 840
++G AV+ G +D F F QLLG ++D++ +D + + +L I + DI
Sbjct: 489 IMGMAVFHGHYIDGGFTLPFYKQLLGKS-----ITLDDMELVDPDLHNSLVWI--LENDI 541
Query: 841 TD-LGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAAL 899
T L T + + G+++ HEL P GK+IPV ENK Y+ L ++R I+ Q AL
Sbjct: 542 TGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLAL 601
Query: 900 ISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDI 959
GF +I ++ F EL+ +I G +ID+ D K +T S+ ++ W W
Sbjct: 602 QKGFNEVIPQHLLKTFDEKELELIICG-LGKIDVNDWKVNTRLKHCTPDSN-IVKWFWKA 659
Query: 960 LASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFF 1019
+ F + RA L+FVT SR PL GF L+ G+ F
Sbjct: 660 V-EFFDEERRARLLQFVTGSSRVPLQGFKALQ--------------------GAAGPRLF 698
Query: 1020 TIRKREP-GGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
TI + + LP + TCFN + +P Y L EKL AI GF
Sbjct: 699 TIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 146 bits (368), Expect = 1e-34
Identities = 118/397 (29%), Positives = 184/397 (46%), Gaps = 54/397 (13%)
Query: 678 PHVTHITIRRSR--MLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFL 735
PH + +T++ SR +LE + R S V F DE +D G +E+
Sbjct: 458 PH-SKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQ-----DEEALDWGGPRREWF 511
Query: 736 EEIIKRVFDPALNLFKTTSGDER--LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIV-- 791
E I K +FD LF S + + ++P+P H L+++EF G+++GK +YE +
Sbjct: 512 ELICKALFDTTNQLFTRFSDNNQALVHPNPNRPAHLR-LKMYEFAGRLVGKCLYESSLGG 570
Query: 792 -----VDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLT 846
V F FL+Q++G Y D D EFYK+ + D++++ L
Sbjct: 571 AYKQLVRARFTRSFLAQIIGLRMHYKYFETD-----DPEFYKSKVCFI-LNNDMSEMELV 624
Query: 847 LSYDE-DVMGQL-VCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFR 904
+ ++ + GQL EL+ GG PVTN NKI Y++L+A +R+ +Q+K + + G
Sbjct: 625 FAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLN 684
Query: 905 SIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGG-FHGSHRVIIWLWDILASD 963
++ + +F EL+ L+ G +I + D K H V GG +H +V+ W W +++S
Sbjct: 685 ELVPENLLAIFDENELELLMCG-TGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSS- 742
Query: 964 FTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRK 1023
T +E A L+F T S+ P GFA L P F I
Sbjct: 743 LTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTH--------------------- 781
Query: 1024 REPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAIS 1060
LPT+ TCFN L LP Y + L+ AIS
Sbjct: 782 ----STLPTAHTCFNQLCLPTYDSYEEVHRMLQLAIS 814
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 127 bits (320), Expect = 4e-29
Identities = 108/397 (27%), Positives = 181/397 (45%), Gaps = 50/397 (12%)
Query: 682 HITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKR 741
++ +RR+ ++ D ++L + + +K ++V FV EAG+D G+ KE+ +I++
Sbjct: 418 NMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVG-----EAGLDMGGLTKEWFLLLIRQ 471
Query: 742 VFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFL 801
+F P +F T D + +S+ +NY + F VG ++G AVY I +D+ F
Sbjct: 472 IFHPDYGMF-TYHKDSHCHWF-SSFKCDNYSE-FRLVGILMGLAVYNSITLDIRFPPCCY 528
Query: 802 SQLLGHHH---------SVFYSSVDELPSLDSEFYKNLTSIKRYDGDIT-DLGLTLSYDE 851
+LL + +VD+L + E L+ + ++G++ D T +
Sbjct: 529 KKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQ 588
Query: 852 DVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEW 911
+ G + + L PGG I VTN+N+ Y+ L F ++ I Q AA GF S+
Sbjct: 589 EEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNA 648
Query: 912 IRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAM 971
+ + E++ L+ G + ++D+ L++ T Y G+ + I + WD++ F D +
Sbjct: 649 LMLLRPEEVEILVCG-SPDLDMHALQRST-QYDGYAKTDLTIKYFWDVVLG-FPLDLQKK 705
Query: 972 FLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGR-L 1030
L F T R P+ G A L F I K E L
Sbjct: 706 LLHFTTGSDRVPVGGMADLN---------------------------FKISKNETSTNCL 738
Query: 1031 PTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1067
P + TCFN L LP Y K L++KL IS + GF L
Sbjct: 739 PVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGL 775
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.139 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,458,117
Number of Sequences: 37866
Number of extensions: 1745484
Number of successful extensions: 5514
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 5259
Number of HSP's gapped (non-prelim): 73
length of query: 1068
length of database: 18,247,518
effective HSP length: 113
effective length of query: 955
effective length of database: 13,968,660
effective search space: 13340070300
effective search space used: 13340070300
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.