Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 35493952

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
         (1068 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]              2147   0.0  
gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]              2147   0.0  
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]              345   1e-94
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]      189   2e-47
gi|114520609 neural precursor cell expressed, developmentally do...   183   7e-46
gi|114520607 neural precursor cell expressed, developmentally do...   183   7e-46
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi...   182   1e-45
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote...   182   2e-45
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...   177   4e-44
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]      176   8e-44
gi|222352183 neural precursor cell expressed, developmentally do...   173   9e-43
gi|21361472 neural precursor cell expressed, developmentally dow...   173   9e-43
gi|222352094 neural precursor cell expressed, developmentally do...   173   9e-43
gi|222352092 neural precursor cell expressed, developmentally do...   173   9e-43
gi|222352090 neural precursor cell expressed, developmentally do...   173   9e-43
gi|222352088 neural precursor cell expressed, developmentally do...   173   9e-43
gi|222352086 neural precursor cell expressed, developmentally do...   173   9e-43
gi|222352084 neural precursor cell expressed, developmentally do...   173   9e-43
gi|222352082 neural precursor cell expressed, developmentally do...   173   9e-43
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i...   172   1e-42
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i...   172   1e-42
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [...   171   4e-42
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H...   161   3e-39
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H...   161   3e-39
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]     159   1e-38
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]     159   1e-38
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]     159   1e-38
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa...   155   3e-37
gi|87116668 hypothetical protein LOC9870 [Homo sapiens]               146   1e-34
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]        127   4e-29

>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
          Length = 1068

 Score = 2147 bits (5563), Expect = 0.0
 Identities = 1068/1068 (100%), Positives = 1068/1068 (100%)

Query: 1    MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDF 60
            MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDF
Sbjct: 1    MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDF 60

Query: 61   FKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSL 120
            FKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSL
Sbjct: 61   FKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSL 120

Query: 121  ACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRG 180
            ACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRG
Sbjct: 121  ACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRG 180

Query: 181  KGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPV 240
            KGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPV
Sbjct: 181  KGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPV 240

Query: 241  IAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV 300
            IAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV
Sbjct: 241  IAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV 300

Query: 301  CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWH 360
            CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWH
Sbjct: 301  CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWH 360

Query: 361  PVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASP 420
            PVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASP
Sbjct: 361  PVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASP 420

Query: 421  QNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQ 480
            QNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQ
Sbjct: 421  QNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQ 480

Query: 481  ILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLI 540
            ILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLI
Sbjct: 481  ILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLI 540

Query: 541  TILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV 600
            TILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV
Sbjct: 541  TILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV 600

Query: 601  LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM 660
            LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM
Sbjct: 601  LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM 660

Query: 661  VTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGV 720
            VTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGV
Sbjct: 661  VTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGV 720

Query: 721  DEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK 780
            DEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK
Sbjct: 721  DEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK 780

Query: 781  MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI 840
            MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI
Sbjct: 781  MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI 840

Query: 841  TDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI 900
            TDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI
Sbjct: 841  TDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI 900

Query: 901  SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDIL 960
            SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDIL
Sbjct: 901  SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDIL 960

Query: 961  ASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFT 1020
            ASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFT
Sbjct: 961  ASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFT 1020

Query: 1021 IRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1068
            IRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS
Sbjct: 1021 IRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1068


>gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]
          Length = 1068

 Score = 2147 bits (5563), Expect = 0.0
 Identities = 1068/1068 (100%), Positives = 1068/1068 (100%)

Query: 1    MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDF 60
            MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDF
Sbjct: 1    MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDF 60

Query: 61   FKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSL 120
            FKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSL
Sbjct: 61   FKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSL 120

Query: 121  ACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRG 180
            ACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRG
Sbjct: 121  ACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRG 180

Query: 181  KGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPV 240
            KGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPV
Sbjct: 181  KGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPV 240

Query: 241  IAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV 300
            IAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV
Sbjct: 241  IAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV 300

Query: 301  CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWH 360
            CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWH
Sbjct: 301  CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWH 360

Query: 361  PVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASP 420
            PVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASP
Sbjct: 361  PVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASP 420

Query: 421  QNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQ 480
            QNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQ
Sbjct: 421  QNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQ 480

Query: 481  ILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLI 540
            ILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLI
Sbjct: 481  ILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLI 540

Query: 541  TILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV 600
            TILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV
Sbjct: 541  TILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV 600

Query: 601  LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM 660
            LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM
Sbjct: 601  LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM 660

Query: 661  VTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGV 720
            VTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGV
Sbjct: 661  VTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGV 720

Query: 721  DEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK 780
            DEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK
Sbjct: 721  DEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK 780

Query: 781  MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI 840
            MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI
Sbjct: 781  MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI 840

Query: 841  TDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI 900
            TDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI
Sbjct: 841  TDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI 900

Query: 901  SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDIL 960
            SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDIL
Sbjct: 901  SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDIL 960

Query: 961  ASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFT 1020
            ASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFT
Sbjct: 961  ASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFT 1020

Query: 1021 IRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1068
            IRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS
Sbjct: 1021 IRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1068


>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
          Length = 1083

 Score =  345 bits (886), Expect = 1e-94
 Identities = 319/1163 (27%), Positives = 513/1163 (44%), Gaps = 207/1163 (17%)

Query: 9    RAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDD--------- 59
            +A  + R ++ R +R  ++ R + A++IQ+ +R +  R + Q  I+R   D         
Sbjct: 25   KASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYRDRKQ-QYSIQRSAFDRCATLSQSG 83

Query: 60   --FFKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWY 117
              F  A+ P  T         + R+LLF ++  ED++R   L ++++          ++ 
Sbjct: 84   GAFPIANGPNLTL--------LVRQLLFFYKQNEDSKRLIWLYQNLI------KHSSLFV 129

Query: 118  VSLACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTW-K 176
              L  S+ LT L+  QIK ++  CC  L+        DS  + L + ML  F+  +T+  
Sbjct: 130  KQLDGSERLTCLF--QIKRLMSLCCRLLQNCN----DDSLNVALPMRMLEVFSSENTYLP 183

Query: 177  ILRGKGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLA 236
            +L+     +      +   I+ ++  +G+Y  L +L+           SK   +  +S  
Sbjct: 184  VLQDASYVV-----SVIEQILHYMIHNGYYRSLYLLIN----------SKLPSSIEYSDL 228

Query: 237  LRPVIAAQFSDNLIRPFLIHIMSVP-ALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQD 295
             R  IA    +N+++P      S P      + T   E        D +  FII      
Sbjct: 229  SRVPIAKILLENVLKPLHFTYNSCPEGARQQVFTAFTEEFLAAPFTDQIFHFII------ 282

Query: 296  RCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVS--QKK 353
                   +L    T+      L+   L       ++ G   L    L     Y+    ++
Sbjct: 283  ------PALADAQTVFPYEPFLNALLLIESRCSRKSGGAPWLFYFVLTVGENYLGALSEE 336

Query: 354  SNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPA 413
              L +   +  + SQ      + S H                    D  S    ES+E  
Sbjct: 337  GLLVYLRVLQTFLSQLPVSPASASCH--------------------DSASDSEEESEEA- 375

Query: 414  HAQPASPQN-VLPVKSLLKRAFQK---SASVRNILRPVGGKRVDSAEVQKVCNIC-VLYQ 468
              +P+SP++  L V  + +   +K         +L  V            + ++C  L  
Sbjct: 376  -DKPSSPEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMV 434

Query: 469  TSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPH---GGLKLFLECLNNDT----EE 521
                 + ++RL  L  L +    L  LW  I  +      G +   L+ ++  +    E+
Sbjct: 435  QHRMMVPKVRL--LYSLAFNARFLRHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFED 492

Query: 522  SKQLLAMLMLFCDCSRHLITILDDIEVYEEQIS-----------FKLEELVTISSFLNSF 570
            S +++ +  LF     H +  + D E + + I            F LEEL+ +S  L   
Sbjct: 493  SSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELIMLSRCLRDA 552

Query: 571  ---VFKMIWDGIVENAKGETLELFQSV----------------HGWLM----------VL 601
               + K+ +       + E +  FQS+                  W+           +L
Sbjct: 553  CLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKML 612

Query: 602  YERDCRRRFTPEDHWL--RKDLKPSVLFQ------------------------------- 628
              RD RR F P +HWL  ++D+K   + Q                               
Sbjct: 613  KSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLES 672

Query: 629  -ELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRR 687
              L    +R   +L  +P V+P + RV +F+ ++  +K++   V+         ++TIRR
Sbjct: 673  PPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQE---VQGDGPFLDGINVTIRR 729

Query: 688  SRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPAL 747
            + + ED Y++L   ++  +K  IRV  +N  G+DEAGID  G+F+EFL E++K  F+P  
Sbjct: 730  NYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQ 789

Query: 748  NLFKTTSGDERLYPSPTS--YIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLL 805
              FKTT+ +  LYP+P +   + +++ + + F+G+MLGKA+YE ++V++PFA FFLS+LL
Sbjct: 790  GFFKTTN-EGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLL 848

Query: 806  GHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPG 865
            G    V    +  L SLD E YKNL  +K Y+ D+ +LGL  +   + +G+    EL  G
Sbjct: 849  GTSADV---DIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFG 905

Query: 866  GKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLIS 925
            GK IPVT+ N+I+YIHL+A +R++ QI+    A   G  +++  EW+RMF   E+Q LIS
Sbjct: 906  GKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLIS 965

Query: 926  GDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLL 985
            G    I LEDLK  T Y GG+   H VI   W ++   FT +E+   LKFVTSCSRPPLL
Sbjct: 966  GAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVV-EGFTDEEKRKLLKFVTSCSRPPLL 1024

Query: 986  GFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNY 1045
            GF  L P F I               GS L             RLPT+STC NLLKLP +
Sbjct: 1025 GFKELYPAFCIH------------NGGSDLE------------RLPTASTCMNLLKLPEF 1060

Query: 1046 SKKSVLREKLRYAISMNTGFELS 1068
              +++LR KL YAI    GFELS
Sbjct: 1061 YDETLLRSKLLYAIECAAGFELS 1083


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score =  189 bits (479), Expect = 2e-47
 Identities = 134/390 (34%), Positives = 200/390 (51%), Gaps = 38/390 (9%)

Query: 683  ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRV 742
            + +RR  + ED Y +L + S   MK  + + F       E G D  G+ +E+   I + +
Sbjct: 4019 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEG-----EEGQDAGGLLREWYMIISREM 4073

Query: 743  FDPALNLFKTTSGDERLYP-SPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFL 801
            F+P   LF+T+ GD   Y  +P+S+ + N+L  F+FVG+++ KAVY+  +++  F   F 
Sbjct: 4074 FNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFY 4133

Query: 802  SQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCH- 860
              +LG   SV Y+ ++   S D  FY+ L  +   + D++ LG  L++  +V    VC  
Sbjct: 4134 KHILGK--SVRYTDME---SEDYHFYQGLVYL--LENDVSTLGYDLTFSTEVQEFGVCEV 4186

Query: 861  -ELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPE 919
             +L P G  I VT ENK  Y+HL+   RM   I+ Q AA + GF  II    I +F+  E
Sbjct: 4187 RDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQE 4246

Query: 920  LQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSC 979
            L+ LISG    ID++DLK +T Y+  +  +   I W W  L S F   +RA FL+FVT  
Sbjct: 4247 LELLISG-LPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRS-FDQADRAKFLQFVTGT 4303

Query: 980  SRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNL 1039
            S+ PL GFA L+    I+  ++  D  + D                   RLP++ TCFN 
Sbjct: 4304 SKVPLQGFAALEGMNGIQKFQIHRDDRSTD-------------------RLPSAHTCFNQ 4344

Query: 1040 LKLPNYSKKSVLREKLRYAI-SMNTGFELS 1068
            L LP Y     LR  L  AI   + GF L+
Sbjct: 4345 LDLPAYESFEKLRHMLLLAIQECSEGFGLA 4374


>gi|114520609 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 1 [Homo sapiens]
          Length = 900

 Score =  183 bits (465), Expect = 7e-46
 Identities = 134/427 (31%), Positives = 218/427 (51%), Gaps = 49/427 (11%)

Query: 644  IPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQ 703
            +P+   +K +   FR  + K+ +           P+   + +RR+ +LED Y ++  + +
Sbjct: 516  VPYSRDYKRKYEFFRRKLKKQND----------IPNKFEMKLRRATVLEDSYRRIMGVKR 565

Query: 704  -HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDE-RLYP 761
               +K  + ++F       E G+D  GV +E+   I K +F+P   LF+ ++ D   L  
Sbjct: 566  ADFLKARLWIEFDG-----EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQI 620

Query: 762  SPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELP 820
            +P S + +E++L  F+F+G++ G AVY G ++D  F   F   +L  H  +   ++ ++ 
Sbjct: 621  NPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML--HKPI---TLHDME 675

Query: 821  SLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYI 880
            S+DSE+Y +L  I   + D T+L L    DE++ GQ   HEL  GG  I VTN+NK  YI
Sbjct: 676  SVDSEYYNSLRWI--LENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYI 733

Query: 881  HLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHT 940
            +L+  +R   +I+ Q AA   GF  +I  + I++F   EL+ L+ G   ++D+ D ++HT
Sbjct: 734  YLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG-LGDVDVNDWREHT 792

Query: 941  VYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCV 999
             Y  G+  +H+VI W W  +L  D   ++R   L+FVT  SR P+ GFA L         
Sbjct: 793  KYKNGYSANHQVIQWFWKAVLMMD--SEKRIRLLQFVTGTSRVPMNGFAEL--------- 841

Query: 1000 EVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAI 1059
                        GS     FT+ +     +LP + TCFN L LP Y     L +KL+ AI
Sbjct: 842  -----------YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAI 890

Query: 1060 SMNTGFE 1066
                GF+
Sbjct: 891  ENTQGFD 897


>gi|114520607 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 2 [Homo sapiens]
          Length = 1247

 Score =  183 bits (465), Expect = 7e-46
 Identities = 134/427 (31%), Positives = 218/427 (51%), Gaps = 49/427 (11%)

Query: 644  IPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQ 703
            +P+   +K +   FR  + K+ +           P+   + +RR+ +LED Y ++  + +
Sbjct: 863  VPYSRDYKRKYEFFRRKLKKQND----------IPNKFEMKLRRATVLEDSYRRIMGVKR 912

Query: 704  -HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDE-RLYP 761
               +K  + ++F       E G+D  GV +E+   I K +F+P   LF+ ++ D   L  
Sbjct: 913  ADFLKARLWIEFDG-----EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQI 967

Query: 762  SPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELP 820
            +P S + +E++L  F+F+G++ G AVY G ++D  F   F   +L  H  +   ++ ++ 
Sbjct: 968  NPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML--HKPI---TLHDME 1022

Query: 821  SLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYI 880
            S+DSE+Y +L  I   + D T+L L    DE++ GQ   HEL  GG  I VTN+NK  YI
Sbjct: 1023 SVDSEYYNSLRWI--LENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYI 1080

Query: 881  HLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHT 940
            +L+  +R   +I+ Q AA   GF  +I  + I++F   EL+ L+ G   ++D+ D ++HT
Sbjct: 1081 YLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG-LGDVDVNDWREHT 1139

Query: 941  VYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCV 999
             Y  G+  +H+VI W W  +L  D   ++R   L+FVT  SR P+ GFA L         
Sbjct: 1140 KYKNGYSANHQVIQWFWKAVLMMD--SEKRIRLLQFVTGTSRVPMNGFAEL--------- 1188

Query: 1000 EVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAI 1059
                        GS     FT+ +     +LP + TCFN L LP Y     L +KL+ AI
Sbjct: 1189 -----------YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAI 1237

Query: 1060 SMNTGFE 1066
                GF+
Sbjct: 1238 ENTQGFD 1244


>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
          Length = 862

 Score =  182 bits (462), Expect = 1e-45
 Identities = 120/391 (30%), Positives = 192/391 (49%), Gaps = 34/391 (8%)

Query: 676  ASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFL 735
            A P    IT+ R  + ED ++Q+   S   ++  + V F       E G+D  GV +E+ 
Sbjct: 502  AMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPG-----EEGLDYGGVAREWF 556

Query: 736  EEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDV 794
              +   V +P   LF+    D   L  +P SYI+ ++L+ F F+G+ +  A++ G  +D 
Sbjct: 557  FLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDT 616

Query: 795  PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
             F+  F  ++L          + +L S+D EFY +L  +K  + +  DL +  S D++++
Sbjct: 617  GFSLPFYKRILNKP-----VGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEIL 671

Query: 855  GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
            G++  H+L P G  I VT ENK  YI ++A +R+   ++ QT A   GF  I+  ++++ 
Sbjct: 672  GEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQY 731

Query: 915  FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLK 974
            F   EL+ L+ G   EIDL D ++H + Y  +  + + I+W W  +  +   ++R   L+
Sbjct: 732  FDAKELEVLLCG-MQEIDLNDWQRHAI-YRHYARTSKQIMWFWQFV-KEIDNEKRMRLLQ 788

Query: 975  FVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSS 1034
            FVT   R P+ GFA                    D +GS     F I K      LP S 
Sbjct: 789  FVTGTCRLPVGGFA--------------------DLMGSNGPQKFCIEKVGKENWLPRSH 828

Query: 1035 TCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
            TCFN L LP Y     L+EKL +AI    GF
Sbjct: 829  TCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859


>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
            ligase 2 [Homo sapiens]
          Length = 1572

 Score =  182 bits (461), Expect = 2e-45
 Identities = 131/393 (33%), Positives = 193/393 (49%), Gaps = 37/393 (9%)

Query: 678  PHVTHITIRRSRMLEDGYEQLRQLSQHAM-KGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
            P    + IRR  +LED + Q+   S+  + +  + V FV      E G+D  G  +EF  
Sbjct: 1213 PGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVG-----EEGLDYSGPSREFFF 1267

Query: 737  EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVP 795
             + + +F+P   LF+ ++ D   +  SP S   +N+ + F F G++LG A+    ++D  
Sbjct: 1268 LVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAF 1327

Query: 796  FASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITD-LGLTLSYDEDVM 854
            F   F   LL          + +L  LD EF+++L  +K  D DI D L LT + +E+V 
Sbjct: 1328 FTRPFYKALLR-----ILCDLSDLEYLDEEFHQSLQWMK--DNDIHDILDLTFTVNEEVF 1380

Query: 855  GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
            GQ+   EL PGG  IPVT +NK  YI  M  +R+   +  QT +L+ GF  ++    + +
Sbjct: 1381 GQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSV 1440

Query: 915  FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLK 974
            F   EL+ +I+G  AEIDL D + +T Y GG+H +H VI W W      F  ++R   L+
Sbjct: 1441 FDARELELVIAG-TAEIDLSDWRNNTEYRGGYHDNHIVIRWFW-AAVERFNNEQRLRLLQ 1498

Query: 975  FVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSS 1034
            FVT  S  P  GFA L+                    GS     F + K      LP + 
Sbjct: 1499 FVTGTSSIPYEGFASLR--------------------GSNGPRRFCVEKWGKITALPRAH 1538

Query: 1035 TCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1067
            TCFN L LP Y   S+L EKL  A+   + F L
Sbjct: 1539 TCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGL 1571


>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
            protein ligase 1 [Homo sapiens]
          Length = 909

 Score =  177 bits (450), Expect = 4e-44
 Identities = 121/379 (31%), Positives = 186/379 (49%), Gaps = 36/379 (9%)

Query: 683  ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRV 742
            + + R  +     E + + +   +K  I V+F  + G+ +      GV +E+ + +   +
Sbjct: 555  LLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQ------GVVREWFDILSNEI 608

Query: 743  FDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLS 802
             +P   LF  ++      P+  SY++ ++L  F F G++LG A+    +V++ F   F  
Sbjct: 609  VNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYK 668

Query: 803  QLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLG--LTLSYDEDVMGQLVCH 860
             +LG        +  ++ S+D E+ KNL  I   D DI+DLG  LT S + DV G +   
Sbjct: 669  HILG-----IPVNYQDVASIDPEYAKNLQWI--LDNDISDLGLELTFSVETDVFGAMEEV 721

Query: 861  ELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPEL 920
             L PGG +I VT  NK  Y+ L+   RM   I+ Q  A + GF   I P  I++F   EL
Sbjct: 722  PLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYEL 781

Query: 921  QRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCS 980
            + L+SG   EID+ D  K+T Y  G+     VI W W+++  D T +ER + L+FVT  S
Sbjct: 782  ELLLSG-MPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVV-EDITQEERVLLLQFVTGSS 839

Query: 981  RPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLL 1040
            R P  GFA +                     GS L+ F           LPTSSTC N+L
Sbjct: 840  RVPHGGFANIMG-------------------GSGLQNFTIAAVPYTPNLLPTSSTCINML 880

Query: 1041 KLPNYSKKSVLREKLRYAI 1059
            KLP Y  K +L+++L  A+
Sbjct: 881  KLPEYPSKEILKDRLLVAL 899


>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
          Length = 1606

 Score =  176 bits (447), Expect = 8e-44
 Identities = 130/393 (33%), Positives = 190/393 (48%), Gaps = 37/393 (9%)

Query: 678  PHVTHITIRRSRMLEDGYEQLRQLSQHAM-KGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
            P    + IRR  +LE  + Q+   S+  + +  + V FV      E G+D  G  +EF  
Sbjct: 1247 PGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVG-----EEGLDYSGPSREFFF 1301

Query: 737  EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVP 795
             + + +F+P   LF+ ++ D   +  SP S   EN+L+ F F G++LG A+    ++D  
Sbjct: 1302 LLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAF 1361

Query: 796  FASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITD-LGLTLSYDEDVM 854
            F   F   LL          + +L  LD EF+++L  +K  D +ITD L LT + +E+V 
Sbjct: 1362 FTRPFYKALLR-----LPCDLSDLEYLDEEFHQSLQWMK--DNNITDILDLTFTVNEEVF 1414

Query: 855  GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
            GQ+   EL  GG    VT +NK  YI  M  +R+   +  QT AL+ GF  ++    + +
Sbjct: 1415 GQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSV 1474

Query: 915  FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLK 974
            F   EL+ +I+G  AEIDL D + +T Y GG+H  H VI W W      F  ++R   L+
Sbjct: 1475 FDARELELVIAG-TAEIDLNDWRNNTEYRGGYHDGHLVIRWFW-AAVERFNNEQRLRLLQ 1532

Query: 975  FVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSS 1034
            FVT  S  P  GFA L+    +R                     F I K      LP + 
Sbjct: 1533 FVTGTSSVPYEGFAALRGSNGLR--------------------RFCIEKWGKITSLPRAH 1572

Query: 1035 TCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1067
            TCFN L LP Y   S+L EKL  A+   + F L
Sbjct: 1573 TCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGL 1605


>gi|222352183 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  173 bits (438), Expect = 9e-43
 Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)

Query: 678  PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
            P+   + + R+ + E+ Y ++  + +   +K  + ++F +     E G+D  GV +E+  
Sbjct: 494  PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 548

Query: 737  EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
             + K +F+P   LF+ ++ D   L  +P S + +E++L  F F+G++ G AV+ G ++D 
Sbjct: 549  LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 608

Query: 795  PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
             F   F   +LG        +++++ S+DSE+Y +L  I   + D T+L L    DE+  
Sbjct: 609  FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 661

Query: 855  GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
            GQ    +L P G  I VTNENK  YI L+  +R   +++ Q  A + GF  ++  + I++
Sbjct: 662  GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 721

Query: 915  FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
            F   EL+ L+ G   ++D+ D ++H++Y  G+  +H VI W W  +L  D   ++R   L
Sbjct: 722  FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 778

Query: 974  KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
            +FVT  SR P+ GFA L                     GS     FTI +     +LP +
Sbjct: 779  QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 818

Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
             TCFN L LP Y     LREKL  A+    GFE
Sbjct: 819  HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 851


>gi|21361472 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score =  173 bits (438), Expect = 9e-43
 Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)

Query: 678  PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
            P+   + + R+ + E+ Y ++  + +   +K  + ++F +     E G+D  GV +E+  
Sbjct: 595  PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 649

Query: 737  EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
             + K +F+P   LF+ ++ D   L  +P S + +E++L  F F+G++ G AV+ G ++D 
Sbjct: 650  LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 709

Query: 795  PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
             F   F   +LG        +++++ S+DSE+Y +L  I   + D T+L L    DE+  
Sbjct: 710  FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 762

Query: 855  GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
            GQ    +L P G  I VTNENK  YI L+  +R   +++ Q  A + GF  ++  + I++
Sbjct: 763  GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 822

Query: 915  FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
            F   EL+ L+ G   ++D+ D ++H++Y  G+  +H VI W W  +L  D   ++R   L
Sbjct: 823  FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 879

Query: 974  KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
            +FVT  SR P+ GFA L                     GS     FTI +     +LP +
Sbjct: 880  QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 919

Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
             TCFN L LP Y     LREKL  A+    GFE
Sbjct: 920  HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 952


>gi|222352094 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  173 bits (438), Expect = 9e-43
 Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)

Query: 678  PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
            P+   + + R+ + E+ Y ++  + +   +K  + ++F +     E G+D  GV +E+  
Sbjct: 474  PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 528

Query: 737  EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
             + K +F+P   LF+ ++ D   L  +P S + +E++L  F F+G++ G AV+ G ++D 
Sbjct: 529  LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 588

Query: 795  PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
             F   F   +LG        +++++ S+DSE+Y +L  I   + D T+L L    DE+  
Sbjct: 589  FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 641

Query: 855  GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
            GQ    +L P G  I VTNENK  YI L+  +R   +++ Q  A + GF  ++  + I++
Sbjct: 642  GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 701

Query: 915  FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
            F   EL+ L+ G   ++D+ D ++H++Y  G+  +H VI W W  +L  D   ++R   L
Sbjct: 702  FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 758

Query: 974  KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
            +FVT  SR P+ GFA L                     GS     FTI +     +LP +
Sbjct: 759  QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 798

Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
             TCFN L LP Y     LREKL  A+    GFE
Sbjct: 799  HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 831


>gi|222352092 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  173 bits (438), Expect = 9e-43
 Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)

Query: 678  PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
            P+   + + R+ + E+ Y ++  + +   +K  + ++F +     E G+D  GV +E+  
Sbjct: 474  PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 528

Query: 737  EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
             + K +F+P   LF+ ++ D   L  +P S + +E++L  F F+G++ G AV+ G ++D 
Sbjct: 529  LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 588

Query: 795  PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
             F   F   +LG        +++++ S+DSE+Y +L  I   + D T+L L    DE+  
Sbjct: 589  FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 641

Query: 855  GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
            GQ    +L P G  I VTNENK  YI L+  +R   +++ Q  A + GF  ++  + I++
Sbjct: 642  GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 701

Query: 915  FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
            F   EL+ L+ G   ++D+ D ++H++Y  G+  +H VI W W  +L  D   ++R   L
Sbjct: 702  FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 758

Query: 974  KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
            +FVT  SR P+ GFA L                     GS     FTI +     +LP +
Sbjct: 759  QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 798

Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
             TCFN L LP Y     LREKL  A+    GFE
Sbjct: 799  HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 831


>gi|222352090 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 5 [Homo sapiens]
          Length = 947

 Score =  173 bits (438), Expect = 9e-43
 Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)

Query: 678  PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
            P+   + + R+ + E+ Y ++  + +   +K  + ++F +     E G+D  GV +E+  
Sbjct: 587  PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 641

Query: 737  EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
             + K +F+P   LF+ ++ D   L  +P S + +E++L  F F+G++ G AV+ G ++D 
Sbjct: 642  LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 701

Query: 795  PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
             F   F   +LG        +++++ S+DSE+Y +L  I   + D T+L L    DE+  
Sbjct: 702  FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 754

Query: 855  GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
            GQ    +L P G  I VTNENK  YI L+  +R   +++ Q  A + GF  ++  + I++
Sbjct: 755  GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 814

Query: 915  FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
            F   EL+ L+ G   ++D+ D ++H++Y  G+  +H VI W W  +L  D   ++R   L
Sbjct: 815  FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 871

Query: 974  KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
            +FVT  SR P+ GFA L                     GS     FTI +     +LP +
Sbjct: 872  QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 911

Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
             TCFN L LP Y     LREKL  A+    GFE
Sbjct: 912  HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 944


>gi|222352088 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 4 [Homo sapiens]
          Length = 967

 Score =  173 bits (438), Expect = 9e-43
 Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)

Query: 678  PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
            P+   + + R+ + E+ Y ++  + +   +K  + ++F +     E G+D  GV +E+  
Sbjct: 607  PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 661

Query: 737  EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
             + K +F+P   LF+ ++ D   L  +P S + +E++L  F F+G++ G AV+ G ++D 
Sbjct: 662  LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 721

Query: 795  PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
             F   F   +LG        +++++ S+DSE+Y +L  I   + D T+L L    DE+  
Sbjct: 722  FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 774

Query: 855  GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
            GQ    +L P G  I VTNENK  YI L+  +R   +++ Q  A + GF  ++  + I++
Sbjct: 775  GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 834

Query: 915  FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
            F   EL+ L+ G   ++D+ D ++H++Y  G+  +H VI W W  +L  D   ++R   L
Sbjct: 835  FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 891

Query: 974  KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
            +FVT  SR P+ GFA L                     GS     FTI +     +LP +
Sbjct: 892  QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 931

Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
             TCFN L LP Y     LREKL  A+    GFE
Sbjct: 932  HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 964


>gi|222352086 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 1 [Homo sapiens]
          Length = 975

 Score =  173 bits (438), Expect = 9e-43
 Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)

Query: 678  PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
            P+   + + R+ + E+ Y ++  + +   +K  + ++F +     E G+D  GV +E+  
Sbjct: 615  PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 669

Query: 737  EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
             + K +F+P   LF+ ++ D   L  +P S + +E++L  F F+G++ G AV+ G ++D 
Sbjct: 670  LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 729

Query: 795  PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
             F   F   +LG        +++++ S+DSE+Y +L  I   + D T+L L    DE+  
Sbjct: 730  FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 782

Query: 855  GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
            GQ    +L P G  I VTNENK  YI L+  +R   +++ Q  A + GF  ++  + I++
Sbjct: 783  GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 842

Query: 915  FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
            F   EL+ L+ G   ++D+ D ++H++Y  G+  +H VI W W  +L  D   ++R   L
Sbjct: 843  FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 899

Query: 974  KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
            +FVT  SR P+ GFA L                     GS     FTI +     +LP +
Sbjct: 900  QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 939

Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
             TCFN L LP Y     LREKL  A+    GFE
Sbjct: 940  HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 972


>gi|222352084 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  173 bits (438), Expect = 9e-43
 Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)

Query: 678  PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
            P+   + + R+ + E+ Y ++  + +   +K  + ++F +     E G+D  GV +E+  
Sbjct: 494  PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 548

Query: 737  EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
             + K +F+P   LF+ ++ D   L  +P S + +E++L  F F+G++ G AV+ G ++D 
Sbjct: 549  LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 608

Query: 795  PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
             F   F   +LG        +++++ S+DSE+Y +L  I   + D T+L L    DE+  
Sbjct: 609  FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 661

Query: 855  GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
            GQ    +L P G  I VTNENK  YI L+  +R   +++ Q  A + GF  ++  + I++
Sbjct: 662  GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 721

Query: 915  FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
            F   EL+ L+ G   ++D+ D ++H++Y  G+  +H VI W W  +L  D   ++R   L
Sbjct: 722  FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 778

Query: 974  KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
            +FVT  SR P+ GFA L                     GS     FTI +     +LP +
Sbjct: 779  QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 818

Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
             TCFN L LP Y     LREKL  A+    GFE
Sbjct: 819  HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 851


>gi|222352082 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  173 bits (438), Expect = 9e-43
 Identities = 122/393 (31%), Positives = 201/393 (51%), Gaps = 39/393 (9%)

Query: 678  PHVTHITIRRSRMLEDGYEQLRQLSQ-HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
            P+   + + R+ + E+ Y ++  + +   +K  + ++F +     E G+D  GV +E+  
Sbjct: 494  PNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFES-----EKGLDYGGVAREWFF 548

Query: 737  EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDV 794
             + K +F+P   LF+ ++ D   L  +P S + +E++L  F F+G++ G AV+ G ++D 
Sbjct: 549  LLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 608

Query: 795  PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
             F   F   +LG        +++++ S+DSE+Y +L  I   + D T+L L    DE+  
Sbjct: 609  FFIRPFYKMMLGKQ-----ITLNDMESVDSEYYNSLKWI--LENDPTELDLMFCIDEENF 661

Query: 855  GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
            GQ    +L P G  I VTNENK  YI L+  +R   +++ Q  A + GF  ++  + I++
Sbjct: 662  GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 721

Query: 915  FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFL 973
            F   EL+ L+ G   ++D+ D ++H++Y  G+  +H VI W W  +L  D   ++R   L
Sbjct: 722  FDENELELLMCG-LGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD--AEKRIRLL 778

Query: 974  KFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTS 1033
            +FVT  SR P+ GFA L                     GS     FTI +     +LP +
Sbjct: 779  QFVTGTSRVPMNGFAEL--------------------YGSNGPQLFTIEQWGSPEKLPRA 818

Query: 1034 STCFNLLKLPNYSKKSVLREKLRYAISMNTGFE 1066
             TCFN L LP Y     LREKL  A+    GFE
Sbjct: 819  HTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 851


>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
            isoform 2 [Homo sapiens]
          Length = 431

 Score =  172 bits (437), Expect = 1e-42
 Identities = 118/393 (30%), Positives = 190/393 (48%), Gaps = 34/393 (8%)

Query: 674  SSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKE 733
            S+A P    I++ R  + ED ++Q+  +  + ++  + +     +   E G+D  G+ +E
Sbjct: 69   SNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYI-----IMRGEEGLDYGGIARE 123

Query: 734  FLEEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVV 792
            +   +   V +P   LF+    +   L  +P S I+ ++L  F F+G+ +  A+Y G  +
Sbjct: 124  WFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFI 183

Query: 793  DVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDED 852
            D  F   F  ++L         ++ +L S+D EFY ++  IK  + +   L L    D +
Sbjct: 184  DTGFTLPFYKRMLNKR-----PTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDME 238

Query: 853  VMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWI 912
            ++G++  HEL  GG++I VT ENK  YI L+  +R    ++ QT A + GF  +   EW+
Sbjct: 239  ILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWL 298

Query: 913  RMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMF 972
            R F   EL+ ++ G   EID+ D +K T+ Y  +  + + I W W ++  +   ++R   
Sbjct: 299  RYFDEKELELMLCG-MQEIDMSDWQKSTI-YRHYTKNSKQIQWFWQVV-KEMDNEKRIRL 355

Query: 973  LKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPT 1032
            L+FVT   R P+ GFA L                    +GS     F I K      LP 
Sbjct: 356  LQFVTGTCRLPVGGFAEL--------------------IGSNGPQKFCIDKVGKETWLPR 395

Query: 1033 SSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
            S TCFN L LP Y     LREKL YAI    GF
Sbjct: 396  SHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 428


>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
            isoform 1 [Homo sapiens]
          Length = 870

 Score =  172 bits (437), Expect = 1e-42
 Identities = 118/393 (30%), Positives = 190/393 (48%), Gaps = 34/393 (8%)

Query: 674  SSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKE 733
            S+A P    I++ R  + ED ++Q+  +  + ++  + +     +   E G+D  G+ +E
Sbjct: 508  SNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYI-----IMRGEEGLDYGGIARE 562

Query: 734  FLEEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVV 792
            +   +   V +P   LF+    +   L  +P S I+ ++L  F F+G+ +  A+Y G  +
Sbjct: 563  WFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFI 622

Query: 793  DVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDED 852
            D  F   F  ++L         ++ +L S+D EFY ++  IK  + +   L L    D +
Sbjct: 623  DTGFTLPFYKRMLNKR-----PTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDME 677

Query: 853  VMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWI 912
            ++G++  HEL  GG++I VT ENK  YI L+  +R    ++ QT A + GF  +   EW+
Sbjct: 678  ILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWL 737

Query: 913  RMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMF 972
            R F   EL+ ++ G   EID+ D +K T+ Y  +  + + I W W ++  +   ++R   
Sbjct: 738  RYFDEKELELMLCG-MQEIDMSDWQKSTI-YRHYTKNSKQIQWFWQVV-KEMDNEKRIRL 794

Query: 973  LKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPT 1032
            L+FVT   R P+ GFA L                    +GS     F I K      LP 
Sbjct: 795  LQFVTGTCRLPVGGFAEL--------------------IGSNGPQKFCIDKVGKETWLPR 834

Query: 1033 SSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
            S TCFN L LP Y     LREKL YAI    GF
Sbjct: 835  SHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 867


>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [Homo
            sapiens]
          Length = 922

 Score =  171 bits (432), Expect = 4e-42
 Identities = 121/395 (30%), Positives = 194/395 (49%), Gaps = 38/395 (9%)

Query: 674  SSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKE 733
            S+A P    I + R  + ED ++Q+  L  + ++  + V F       E G+D  G+ +E
Sbjct: 560  SNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRG-----EEGLDYGGLARE 614

Query: 734  FLEEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVV 792
            +   +   V +P   LF+    +   L  +P S I+ ++L  F F+G+ +  A++ G  +
Sbjct: 615  WFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFI 674

Query: 793  DVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTL--SYD 850
            D  F+  F  ++L         ++ +L S+D+EFY +L  I+  D +I + GL +  S D
Sbjct: 675  DTGFSLPFYKRMLSKK-----LTIKDLESIDTEFYNSLIWIR--DNNIEECGLEMYFSVD 727

Query: 851  EDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPE 910
             +++G++  H+L  GG  I VT ENK  YI LM  +R    ++ QT A + GF  ++  +
Sbjct: 728  MEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQ 787

Query: 911  WIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERA 970
            W++ F   EL+ ++ G   E+DL D +++TV Y  +  + + IIW W  +  +   + R 
Sbjct: 788  WLQYFDEKELEVMLCG-MQEVDLADWQRNTV-YRHYTRNSKQIIWFWQFV-KETDNEVRM 844

Query: 971  MFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRL 1030
              L+FVT   R PL GFA L                    +GS     F I K      L
Sbjct: 845  RLLQFVTGTCRLPLGGFAEL--------------------MGSNGPQKFCIEKVGKDTWL 884

Query: 1031 PTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
            P S TCFN L LP Y     L+EKL +AI    GF
Sbjct: 885  PRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919


>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
            sapiens]
          Length = 757

 Score =  161 bits (407), Expect = 3e-39
 Identities = 127/407 (31%), Positives = 195/407 (47%), Gaps = 37/407 (9%)

Query: 664  EKEKLGLVETSSASPHVTH--ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVD 721
            +K K+   E S   P   H  I + R  + E+ Y Q+ ++    +K  + VKF       
Sbjct: 380  QKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRG----- 434

Query: 722  EAGIDQDGVFKEFLEEIIKRVFDPALNLFK-TTSGDERLYPSPTSYIHENYLQLFEFVGK 780
            E G+D  GV +E+L  +   + +P   LF+ +T     L  +P S I+ ++L  F FVG+
Sbjct: 435  EEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGR 494

Query: 781  MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI 840
            ++G AV+ G  ++  F   F  QLLG         + +L S+D E +K+L  I   + DI
Sbjct: 495  IMGLAVFHGHYINGGFTVPFYKQLLGKP-----IQLSDLESVDPELHKSLVWI--LENDI 547

Query: 841  TD-LGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAAL 899
            T  L  T   + +  G+++ HEL P G+ +PVT ENK  Y+ L  ++R    I+ Q  AL
Sbjct: 548  TPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLAL 607

Query: 900  ISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDI 959
              GF  +I    ++ F   EL+ +I G + +IDL D K +T        S+ ++ W W  
Sbjct: 608  QKGFNELIPQHLLKPFDQKELELIIGGLD-KIDLNDWKSNTRLKHCVADSN-IVRWFWQA 665

Query: 960  LASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFF 1019
            + + F  + RA  L+FVT  +R PL GF  L+                G T G+     F
Sbjct: 666  VET-FDEERRARLLQFVTGSTRVPLQGFKALQ----------------GST-GAAGPRLF 707

Query: 1020 TIRKREPG-GRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
            TI   +     LP + TCFN + +P Y     L EKL  A+    GF
Sbjct: 708  TIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 754


>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
            sapiens]
          Length = 731

 Score =  161 bits (407), Expect = 3e-39
 Identities = 127/407 (31%), Positives = 195/407 (47%), Gaps = 37/407 (9%)

Query: 664  EKEKLGLVETSSASPHVTH--ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVD 721
            +K K+   E S   P   H  I + R  + E+ Y Q+ ++    +K  + VKF       
Sbjct: 354  QKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRG----- 408

Query: 722  EAGIDQDGVFKEFLEEIIKRVFDPALNLFK-TTSGDERLYPSPTSYIHENYLQLFEFVGK 780
            E G+D  GV +E+L  +   + +P   LF+ +T     L  +P S I+ ++L  F FVG+
Sbjct: 409  EEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGR 468

Query: 781  MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI 840
            ++G AV+ G  ++  F   F  QLLG         + +L S+D E +K+L  I   + DI
Sbjct: 469  IMGLAVFHGHYINGGFTVPFYKQLLGKP-----IQLSDLESVDPELHKSLVWI--LENDI 521

Query: 841  TD-LGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAAL 899
            T  L  T   + +  G+++ HEL P G+ +PVT ENK  Y+ L  ++R    I+ Q  AL
Sbjct: 522  TPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLAL 581

Query: 900  ISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDI 959
              GF  +I    ++ F   EL+ +I G + +IDL D K +T        S+ ++ W W  
Sbjct: 582  QKGFNELIPQHLLKPFDQKELELIIGGLD-KIDLNDWKSNTRLKHCVADSN-IVRWFWQA 639

Query: 960  LASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFF 1019
            + + F  + RA  L+FVT  +R PL GF  L+                G T G+     F
Sbjct: 640  VET-FDEERRARLLQFVTGSTRVPLQGFKALQ----------------GST-GAAGPRLF 681

Query: 1020 TIRKREPG-GRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
            TI   +     LP + TCFN + +P Y     L EKL  A+    GF
Sbjct: 682  TIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728


>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
          Length = 872

 Score =  159 bits (403), Expect = 1e-38
 Identities = 120/475 (25%), Positives = 222/475 (46%), Gaps = 54/475 (11%)

Query: 605  DCRRRFTPEDHWLRKDLKPSV------LFQELDRDRKRAQLILQYIPHVIPHKNRVLLFR 658
            DCR+   P + ++ + L   +       F +++ + K + +   +I + +  KN  L + 
Sbjct: 435  DCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVT-KNLGLYYD 493

Query: 659  TMVTKEKEK-----LGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVK 713
              +    E+       LV+    +P++  + +RR  +++D   +L  ++      + +  
Sbjct: 494  NRIRMYSERRITVLYSLVQGQQLNPYL-RLKVRRDHIIDDALVRLEMIAMENPADLKKQL 552

Query: 714  FVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQ 773
            +V   G  E G+D+ GV KEF + +++ +F+P + +F      +  + +P+S+  E    
Sbjct: 553  YVEFEG--EQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ-- 608

Query: 774  LFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSI 833
             F  +G +LG A+Y   ++DV F      +L+G     F    D  P L    Y++L  +
Sbjct: 609  -FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKK-GTFRDLGDSHPVL----YQSLKDL 662

Query: 834  KRYDGDITD-LGLTLSYDE-DVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQ 891
              Y+G++ D + +T    + D+ G  + ++L   G  IP+TNEN+  +++L + + ++  
Sbjct: 663  LEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKS 722

Query: 892  IKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHR 951
            ++ Q  A   GF  +     ++    PE   L+   +  +D + L++ T Y GG+     
Sbjct: 723  VEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSV 782

Query: 952  VIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTL 1011
            +I   W+I+ S FT +++ +FL+F T   R P+ G   LK                    
Sbjct: 783  LIREFWEIVHS-FTDEQKRLFLQFTTGTDRAPVGGLGKLK-------------------- 821

Query: 1012 GSVLRGFFTIRKREPGG-RLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
                     I K  P   RLPTS TCFN+L LP YS K  L+E+L  AI+   GF
Sbjct: 822  -------MIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 869


>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
          Length = 852

 Score =  159 bits (403), Expect = 1e-38
 Identities = 120/475 (25%), Positives = 222/475 (46%), Gaps = 54/475 (11%)

Query: 605  DCRRRFTPEDHWLRKDLKPSV------LFQELDRDRKRAQLILQYIPHVIPHKNRVLLFR 658
            DCR+   P + ++ + L   +       F +++ + K + +   +I + +  KN  L + 
Sbjct: 415  DCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVT-KNLGLYYD 473

Query: 659  TMVTKEKEK-----LGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVK 713
              +    E+       LV+    +P++  + +RR  +++D   +L  ++      + +  
Sbjct: 474  NRIRMYSERRITVLYSLVQGQQLNPYL-RLKVRRDHIIDDALVRLEMIAMENPADLKKQL 532

Query: 714  FVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQ 773
            +V   G  E G+D+ GV KEF + +++ +F+P + +F      +  + +P+S+  E    
Sbjct: 533  YVEFEG--EQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ-- 588

Query: 774  LFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSI 833
             F  +G +LG A+Y   ++DV F      +L+G     F    D  P L    Y++L  +
Sbjct: 589  -FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKK-GTFRDLGDSHPVL----YQSLKDL 642

Query: 834  KRYDGDITD-LGLTLSYDE-DVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQ 891
              Y+G++ D + +T    + D+ G  + ++L   G  IP+TNEN+  +++L + + ++  
Sbjct: 643  LEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKS 702

Query: 892  IKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHR 951
            ++ Q  A   GF  +     ++    PE   L+   +  +D + L++ T Y GG+     
Sbjct: 703  VEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSV 762

Query: 952  VIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTL 1011
            +I   W+I+ S FT +++ +FL+F T   R P+ G   LK                    
Sbjct: 763  LIREFWEIVHS-FTDEQKRLFLQFTTGTDRAPVGGLGKLK-------------------- 801

Query: 1012 GSVLRGFFTIRKREPGG-RLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
                     I K  P   RLPTS TCFN+L LP YS K  L+E+L  AI+   GF
Sbjct: 802  -------MIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 849


>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
          Length = 875

 Score =  159 bits (403), Expect = 1e-38
 Identities = 120/475 (25%), Positives = 222/475 (46%), Gaps = 54/475 (11%)

Query: 605  DCRRRFTPEDHWLRKDLKPSV------LFQELDRDRKRAQLILQYIPHVIPHKNRVLLFR 658
            DCR+   P + ++ + L   +       F +++ + K + +   +I + +  KN  L + 
Sbjct: 438  DCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVT-KNLGLYYD 496

Query: 659  TMVTKEKEK-----LGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVK 713
              +    E+       LV+    +P++  + +RR  +++D   +L  ++      + +  
Sbjct: 497  NRIRMYSERRITVLYSLVQGQQLNPYL-RLKVRRDHIIDDALVRLEMIAMENPADLKKQL 555

Query: 714  FVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQ 773
            +V   G  E G+D+ GV KEF + +++ +F+P + +F      +  + +P+S+  E    
Sbjct: 556  YVEFEG--EQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ-- 611

Query: 774  LFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSI 833
             F  +G +LG A+Y   ++DV F      +L+G     F    D  P L    Y++L  +
Sbjct: 612  -FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKK-GTFRDLGDSHPVL----YQSLKDL 665

Query: 834  KRYDGDITD-LGLTLSYDE-DVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQ 891
              Y+G++ D + +T    + D+ G  + ++L   G  IP+TNEN+  +++L + + ++  
Sbjct: 666  LEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKS 725

Query: 892  IKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHR 951
            ++ Q  A   GF  +     ++    PE   L+   +  +D + L++ T Y GG+     
Sbjct: 726  VEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSV 785

Query: 952  VIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTL 1011
            +I   W+I+ S FT +++ +FL+F T   R P+ G   LK                    
Sbjct: 786  LIREFWEIVHS-FTDEQKRLFLQFTTGTDRAPVGGLGKLK-------------------- 824

Query: 1012 GSVLRGFFTIRKREPGG-RLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
                     I K  P   RLPTS TCFN+L LP YS K  L+E+L  AI+   GF
Sbjct: 825  -------MIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 872


>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
            sapiens]
          Length = 748

 Score =  155 bits (391), Expect = 3e-37
 Identities = 122/407 (29%), Positives = 190/407 (46%), Gaps = 40/407 (9%)

Query: 664  EKEKLGLVETSSASPHVTH--ITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVD 721
            +K K+   E S   P   H  I + R  + E+ Y Q+ ++    +   + +KF       
Sbjct: 374  QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRG----- 428

Query: 722  EAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGD-ERLYPSPTSYIHENYLQLFEFVGK 780
            E G+D  GV +E+L  +   + +P   LF+ +  D   L  +P S ++  +L  F FVG+
Sbjct: 429  EEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGR 488

Query: 781  MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI 840
            ++G AV+ G  +D  F   F  QLLG        ++D++  +D + + +L  I   + DI
Sbjct: 489  IMGMAVFHGHYIDGGFTLPFYKQLLGKS-----ITLDDMELVDPDLHNSLVWI--LENDI 541

Query: 841  TD-LGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAAL 899
            T  L  T   + +  G+++ HEL P GK+IPV  ENK  Y+ L  ++R    I+ Q  AL
Sbjct: 542  TGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLAL 601

Query: 900  ISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDI 959
              GF  +I    ++ F   EL+ +I G   +ID+ D K +T        S+ ++ W W  
Sbjct: 602  QKGFNEVIPQHLLKTFDEKELELIICG-LGKIDVNDWKVNTRLKHCTPDSN-IVKWFWKA 659

Query: 960  LASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFF 1019
            +   F  + RA  L+FVT  SR PL GF  L+                    G+     F
Sbjct: 660  V-EFFDEERRARLLQFVTGSSRVPLQGFKALQ--------------------GAAGPRLF 698

Query: 1020 TIRKREP-GGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
            TI + +     LP + TCFN + +P Y     L EKL  AI    GF
Sbjct: 699  TIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745


>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
          Length = 823

 Score =  146 bits (368), Expect = 1e-34
 Identities = 118/397 (29%), Positives = 184/397 (46%), Gaps = 54/397 (13%)

Query: 678  PHVTHITIRRSR--MLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFL 735
            PH + +T++ SR  +LE   +  R  S         V F      DE  +D  G  +E+ 
Sbjct: 458  PH-SKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQ-----DEEALDWGGPRREWF 511

Query: 736  EEIIKRVFDPALNLFKTTSGDER--LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIV-- 791
            E I K +FD    LF   S + +  ++P+P    H   L+++EF G+++GK +YE  +  
Sbjct: 512  ELICKALFDTTNQLFTRFSDNNQALVHPNPNRPAHLR-LKMYEFAGRLVGKCLYESSLGG 570

Query: 792  -----VDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLT 846
                 V   F   FL+Q++G      Y   D     D EFYK+       + D++++ L 
Sbjct: 571  AYKQLVRARFTRSFLAQIIGLRMHYKYFETD-----DPEFYKSKVCFI-LNNDMSEMELV 624

Query: 847  LSYDE-DVMGQL-VCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFR 904
             + ++ +  GQL    EL+ GG   PVTN NKI Y++L+A +R+ +Q+K +    + G  
Sbjct: 625  FAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLN 684

Query: 905  SIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGG-FHGSHRVIIWLWDILASD 963
             ++    + +F   EL+ L+ G   +I + D K H V  GG +H   +V+ W W +++S 
Sbjct: 685  ELVPENLLAIFDENELELLMCG-TGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSS- 742

Query: 964  FTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRK 1023
             T +E A  L+F T  S+ P  GFA L P F I                           
Sbjct: 743  LTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTH--------------------- 781

Query: 1024 REPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAIS 1060
                  LPT+ TCFN L LP Y     +   L+ AIS
Sbjct: 782  ----STLPTAHTCFNQLCLPTYDSYEEVHRMLQLAIS 814


>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
          Length = 776

 Score =  127 bits (320), Expect = 4e-29
 Identities = 108/397 (27%), Positives = 181/397 (45%), Gaps = 50/397 (12%)

Query: 682  HITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKR 741
            ++ +RR+ ++ D  ++L +  +  +K  ++V FV      EAG+D  G+ KE+   +I++
Sbjct: 418  NMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVG-----EAGLDMGGLTKEWFLLLIRQ 471

Query: 742  VFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFL 801
            +F P   +F T   D   +   +S+  +NY + F  VG ++G AVY  I +D+ F     
Sbjct: 472  IFHPDYGMF-TYHKDSHCHWF-SSFKCDNYSE-FRLVGILMGLAVYNSITLDIRFPPCCY 528

Query: 802  SQLLGHHH---------SVFYSSVDELPSLDSEFYKNLTSIKRYDGDIT-DLGLTLSYDE 851
             +LL              +   +VD+L  +  E    L+ +  ++G++  D   T    +
Sbjct: 529  KKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQ 588

Query: 852  DVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEW 911
            +  G +  + L PGG  I VTN+N+  Y+ L   F ++  I  Q AA   GF S+     
Sbjct: 589  EEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNA 648

Query: 912  IRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAM 971
            + +    E++ L+ G + ++D+  L++ T  Y G+  +   I + WD++   F  D +  
Sbjct: 649  LMLLRPEEVEILVCG-SPDLDMHALQRST-QYDGYAKTDLTIKYFWDVVLG-FPLDLQKK 705

Query: 972  FLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGR-L 1030
             L F T   R P+ G A L                            F I K E     L
Sbjct: 706  LLHFTTGSDRVPVGGMADLN---------------------------FKISKNETSTNCL 738

Query: 1031 PTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1067
            P + TCFN L LP Y  K  L++KL   IS + GF L
Sbjct: 739  PVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGL 775


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.139    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,458,117
Number of Sequences: 37866
Number of extensions: 1745484
Number of successful extensions: 5514
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 5259
Number of HSP's gapped (non-prelim): 73
length of query: 1068
length of database: 18,247,518
effective HSP length: 113
effective length of query: 955
effective length of database: 13,968,660
effective search space: 13340070300
effective search space used: 13340070300
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press