BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|34916000 FERM domain containing 7 [Homo sapiens] (714 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|34916000 FERM domain containing 7 [Homo sapiens] 1452 0.0 gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 431 e-120 gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 388 e-108 gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 243 4e-64 gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 240 3e-63 gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 239 5e-63 gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 236 5e-62 gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 236 7e-62 gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 236 7e-62 gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 236 7e-62 gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 234 2e-61 gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 234 2e-61 gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 208 1e-53 gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 197 4e-50 gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 193 5e-49 gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 192 7e-49 gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 189 8e-48 gi|117500790 FERM domain containing 3 [Homo sapiens] 182 7e-46 gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 174 3e-43 gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 174 3e-43 gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 172 1e-42 gi|4506467 radixin [Homo sapiens] 125 2e-28 gi|4505257 moesin [Homo sapiens] 124 4e-28 gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 122 9e-28 gi|161702986 ezrin [Homo sapiens] 117 5e-26 gi|21614499 ezrin [Homo sapiens] 117 5e-26 gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 111 3e-24 gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 111 3e-24 gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 111 3e-24 gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 111 3e-24 >gi|34916000 FERM domain containing 7 [Homo sapiens] Length = 714 Score = 1452 bits (3758), Expect = 0.0 Identities = 714/714 (100%), Positives = 714/714 (100%) Query: 1 MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELL 60 MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELL Sbjct: 1 MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELL 60 Query: 61 KPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTAL 120 KPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTAL Sbjct: 61 KPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTAL 120 Query: 121 MVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDI 180 MVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDI Sbjct: 121 MVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDI 180 Query: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI Sbjct: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240 Query: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR Sbjct: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300 Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGG 360 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGG Sbjct: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGG 360 Query: 361 GYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYMD 420 GYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYMD Sbjct: 361 GYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYMD 420 Query: 421 PVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVPY 480 PVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVPY Sbjct: 421 PVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVPY 480 Query: 481 IPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVEPTAMKPAERSPRNIRM 540 IPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVEPTAMKPAERSPRNIRM Sbjct: 481 IPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVEPTAMKPAERSPRNIRM 540 Query: 541 KSFQQDLQVLQEAIARTSGRSNINVGLEEEDPNLEDAFVCNIQEQTPKRSQSQSDMKTIR 600 KSFQQDLQVLQEAIARTSGRSNINVGLEEEDPNLEDAFVCNIQEQTPKRSQSQSDMKTIR Sbjct: 541 KSFQQDLQVLQEAIARTSGRSNINVGLEEEDPNLEDAFVCNIQEQTPKRSQSQSDMKTIR 600 Query: 601 FPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILKP 660 FPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILKP Sbjct: 601 FPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILKP 660 Query: 661 DYYALYGKEIRSPMARIRLSSGSLQLDEEDEDAYFNTPTAEDRTSLKPCNYFLA 714 DYYALYGKEIRSPMARIRLSSGSLQLDEEDEDAYFNTPTAEDRTSLKPCNYFLA Sbjct: 661 DYYALYGKEIRSPMARIRLSSGSLQLDEEDEDAYFNTPTAEDRTSLKPCNYFLA 714 >gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1 [Homo sapiens] Length = 1045 Score = 431 bits (1107), Expect = e-120 Identities = 231/443 (52%), Positives = 299/443 (67%), Gaps = 22/443 (4%) Query: 1 MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELL 60 ++ +K+Q LDD+Q+ F V Q++ GK L + C+HLNL E +YFGLEF H VWL+LL Sbjct: 39 LVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLL 98 Query: 61 KPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTAL 120 KPI KQ++ PK +V KF+VKFFP D L+EELTRYLF LQ+K+DLA GRL C+D AL Sbjct: 99 KPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAAL 158 Query: 121 MVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDI 180 ++SHI+QSE+GDF E DR+HLA+ +Y+P QD LE KI+ FH HIG++PAESD LL+I Sbjct: 159 LISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEI 218 Query: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240 AR+L+MYGIR HPA D EG +I+LAVA+ G+LV +G TKIN FNWAK+RKLSFKRK FLI Sbjct: 219 ARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLI 278 Query: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300 KL + +DTLEF MASRD CK+FWK CVE+HAFFRL EEPK KPK +L S+GSSFR Sbjct: 279 KLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFR 338 Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHE-RQCRSSP-DLLSDVSKQ-VEDLRLA 357 +SGRTQ+Q+L+Y ++G K + FERKH S+ H R S P +L S+V +Q + L Sbjct: 339 FSGRTQKQVLDYVKEGGHKKVQFERKH--SKIHSIRSLASQPTELNSEVLEQSQQSTSLT 396 Query: 358 YGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSK--PEADPTLLHQSQSSSSFP 415 +G G A P +S RR +V+ H P P Q+ ++S P Sbjct: 397 FGEG---------AESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAP 447 Query: 416 F-----IYMDPVFNTEPNPNPDP 433 + D ++P P P P Sbjct: 448 TEEEEEVVKDRTQQSKPQP-PQP 469 >gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sapiens] Length = 1054 Score = 388 bits (997), Expect = e-108 Identities = 187/327 (57%), Positives = 241/327 (73%), Gaps = 2/327 (0%) Query: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61 LHL+V+ LD++ +IF ++ K G+ L LNL E +YFG+EF + +WLE +K Sbjct: 44 LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMK 103 Query: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121 PI +Q++ PK +V + VKFFP DPG L+EE TRYLF LQ+K+DL RL C+D AL+ Sbjct: 104 PIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALL 163 Query: 122 VSHILQSELGDFHEETDRKHLAQTRYLPNQD-CLEGKIMHFHQKHIGRSPAESDILLLDI 180 SH+LQSE+GD+ E DR+HL YLP Q CLE KI+ FHQKH+G++PAESD +L+I Sbjct: 164 TSHLLQSEIGDYDETLDREHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAESDFQVLEI 222 Query: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240 ARKL+MYGIR H ASD EG +I LAV+HMGVLV +G TKINTFNW+K+RKLSFKRK FLI Sbjct: 223 ARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLI 282 Query: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300 KLH + +DTLEF + SRD CK FWK CVEYH FFRL ++PK K K + S+GSSFR Sbjct: 283 KLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFR 342 Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKH 327 YSGRTQ+QL++Y + +K +P+ER+H Sbjct: 343 YSGRTQKQLVDYFKDSGMKRIPYERRH 369 >gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo sapiens] Length = 1087 Score = 243 bits (620), Expect = 4e-64 Identities = 163/488 (33%), Positives = 244/488 (50%), Gaps = 30/488 (6%) Query: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61 + KV LD S+ V+++S G+ LF+ C HLNL EK+YFGL + WL+ K Sbjct: 110 MQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAK 169 Query: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121 I KQV++ F F VKF+P DP L E++TRY LQ++ D+ GRLPCS AL+ Sbjct: 170 EIKKQVRSGAWH-FSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALL 228 Query: 122 VSHILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLD 179 S+ +QSELGD+ +E ++++ R+ PN LE K++ H+ H G +PAE+++ L+ Sbjct: 229 GSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLE 288 Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239 A+KL MYG+ H A D EG++I L V G+L+ R +IN F W K+ K+S+KR +F Sbjct: 289 NAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFY 348 Query: 240 IKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSF 299 IK+ + T+ F + + A K WK CVE+H FFRL P++ PK L + GS F Sbjct: 349 IKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLL-LPEAPPKKFL-TLGSKF 406 Query: 300 RYSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYG 359 RYSGRTQ Q R S +R P+ Y ER + + +V G Sbjct: 407 RYSGRTQAQT-------RRASALIDR---PAPYFERSSSKRYTMSRSLDGEV-------G 449 Query: 360 GGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYM 419 G Y G+ + + A E E + K E + T + + P + Sbjct: 450 TGQYATTKGISQTNLITTVTPEKKAEEERDEEEDKRRKGE-EVTPISAIRHEGKSPGLGT 508 Query: 420 DPVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVP 479 D + P+ + P +S + + CK + + Y ++ P + +D P Sbjct: 509 DSCPLSPPSTHCAP-------TSPTELRRRCKENDCKLPGYEPSRAEHLPGEPALDSDGP 561 Query: 480 YIPCTGQQ 487 P G Q Sbjct: 562 GRPYLGDQ 569 >gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a [Homo sapiens] Length = 881 Score = 240 bits (613), Expect = 3e-63 Identities = 149/409 (36%), Positives = 217/409 (53%), Gaps = 17/409 (4%) Query: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64 +V LD S+ V++ G+ LF+L C HLNL EK+YFGL FC WL+ K I Sbjct: 100 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 159 Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124 KQ+++ F F VKF+P DP L E++TRY LQ++ D+ GRLPCS AL+ S+ Sbjct: 160 KQIRS-SPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 218 Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182 +Q+ELGD+ EE ++++ R+ PNQ LE +IM H+ + G +P E++I L+ A+ Sbjct: 219 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 278 Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242 KL MYG+ H A D EG+ I L V G+L+ R +IN F W KI K+S+KR +F IK+ Sbjct: 279 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 338 Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302 + T+ F + + + K WK C+E+H FFRL P+ PK L GS FRYS Sbjct: 339 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL-VSPEPPPKGFLV-MGSKFRYS 396 Query: 303 GRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGGGY 362 GRTQ Q R S +R P+ + ER + + + + Sbjct: 397 GRTQAQT-------RQASALIDR---PAPFFERSSSKRYTMSRSLDGAEFSRPASVSENH 446 Query: 363 YQNVNGVHASEPVLESRRRNSAL--EVTFATELEHSKPEADPTLLHQSQ 409 +G E +R+ A EV T+++ KPE + T H+ + Sbjct: 447 DAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQE 495 >gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b [Homo sapiens] Length = 779 Score = 239 bits (611), Expect = 5e-63 Identities = 131/306 (42%), Positives = 183/306 (59%), Gaps = 5/306 (1%) Query: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64 +V LD S+ V++ G+ LF+L C HLNL EK+YFGL FC WL+ K I Sbjct: 38 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 97 Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124 KQ+++ F F VKF+P DP L E++TRY LQ++ D+ GRLPCS AL+ S+ Sbjct: 98 KQIRS-SPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 156 Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182 +Q+ELGD+ EE ++++ R+ PNQ LE +IM H+ + G +P E++I L+ A+ Sbjct: 157 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 216 Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242 KL MYG+ H A D EG+ I L V G+L+ R +IN F W KI K+S+KR +F IK+ Sbjct: 217 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 276 Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302 + T+ F + + + K WK C+E+H FFRL P+ PK L GS FRYS Sbjct: 277 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL-VSPEPPPKGFLV-MGSKFRYS 334 Query: 303 GRTQRQ 308 GRTQ Q Sbjct: 335 GRTQAQ 340 >gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo sapiens] Length = 926 Score = 236 bits (602), Expect = 5e-62 Identities = 131/326 (40%), Positives = 188/326 (57%), Gaps = 7/326 (2%) Query: 6 VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNV-WLELLKPIT 64 + LD++ + F V++ G+ L ++ HL+L E++YFGL+ S +N WL+ KPI Sbjct: 33 ILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIR 92 Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124 KQ+K F VKFF DP L+EE TRY + LQIK+D+ GRLPC N AL+ S Sbjct: 93 KQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASF 152 Query: 125 ILQSELGDFHEETDRK-HLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLDIAR 182 +QSELGD+ + + +L+ ++PNQ E +I HQ+HIG SPAE++ L+ AR Sbjct: 153 AVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNTAR 212 Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242 L++YG+ H A D +I + V G+L+ + ++NTF W KI K+SFK K F I+L Sbjct: 213 TLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFIQL 272 Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLC---SKGSSF 299 + + L F M + ACK WK CVE+H FFRL + P K + GS F Sbjct: 273 RKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRL-DRPLPPQKNFFAHYFTLGSKF 331 Query: 300 RYSGRTQRQLLEYGRKGRLKSLPFER 325 RY GRT+ Q ++YG++ K F R Sbjct: 332 RYCGRTEVQSVQYGKEKANKDRVFAR 357 >gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b [Homo sapiens] Length = 673 Score = 236 bits (601), Expect = 7e-62 Identities = 129/306 (42%), Positives = 183/306 (59%), Gaps = 4/306 (1%) Query: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64 KV LD ++ +++ + G+ LF+ C HLNL EK+YFGL F WL+ K I Sbjct: 221 KVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIK 280 Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124 +Q++N + F F VKF+P DP L E++TRY LQ+++D+A GRLPCS AL+ S+ Sbjct: 281 RQLRNLPWL-FTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSY 339 Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182 LQ+ELGD+ EE L++ ++ P Q LE K+ H+ H G SPA++D L+ A+ Sbjct: 340 TLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAK 399 Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242 +L MYG+ H A D EG+ I L V G+L+ + +IN F W KI K+S+KR +F IK+ Sbjct: 400 RLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKV 459 Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302 L + T+ F + + A K WK CVE+H F+RL P+ PK + GS FRYS Sbjct: 460 RPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL-VSPEQPPKAKFLTLGSKFRYS 518 Query: 303 GRTQRQ 308 GRTQ Q Sbjct: 519 GRTQAQ 524 >gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b [Homo sapiens] Length = 673 Score = 236 bits (601), Expect = 7e-62 Identities = 129/306 (42%), Positives = 183/306 (59%), Gaps = 4/306 (1%) Query: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64 KV LD ++ +++ + G+ LF+ C HLNL EK+YFGL F WL+ K I Sbjct: 221 KVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIK 280 Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124 +Q++N + F F VKF+P DP L E++TRY LQ+++D+A GRLPCS AL+ S+ Sbjct: 281 RQLRNLPWL-FTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSY 339 Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182 LQ+ELGD+ EE L++ ++ P Q LE K+ H+ H G SPA++D L+ A+ Sbjct: 340 TLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAK 399 Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242 +L MYG+ H A D EG+ I L V G+L+ + +IN F W KI K+S+KR +F IK+ Sbjct: 400 RLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKV 459 Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302 L + T+ F + + A K WK CVE+H F+RL P+ PK + GS FRYS Sbjct: 460 RPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL-VSPEQPPKAKFLTLGSKFRYS 518 Query: 303 GRTQRQ 308 GRTQ Q Sbjct: 519 GRTQAQ 524 >gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a [Homo sapiens] Length = 1005 Score = 236 bits (601), Expect = 7e-62 Identities = 129/306 (42%), Positives = 183/306 (59%), Gaps = 4/306 (1%) Query: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64 KV LD ++ +++ + G+ LF+ C HLNL EK+YFGL F WL+ K I Sbjct: 221 KVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIK 280 Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124 +Q++N + F F VKF+P DP L E++TRY LQ+++D+A GRLPCS AL+ S+ Sbjct: 281 RQLRNLPWL-FTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSY 339 Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182 LQ+ELGD+ EE L++ ++ P Q LE K+ H+ H G SPA++D L+ A+ Sbjct: 340 TLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAK 399 Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242 +L MYG+ H A D EG+ I L V G+L+ + +IN F W KI K+S+KR +F IK+ Sbjct: 400 RLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKV 459 Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302 L + T+ F + + A K WK CVE+H F+RL P+ PK + GS FRYS Sbjct: 460 RPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL-VSPEQPPKAKFLTLGSKFRYS 518 Query: 303 GRTQRQ 308 GRTQ Q Sbjct: 519 GRTQAQ 524 >gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) isoform 2 [Homo sapiens] Length = 641 Score = 234 bits (597), Expect = 2e-61 Identities = 128/309 (41%), Positives = 182/309 (58%), Gaps = 4/309 (1%) Query: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61 +H KV LDD+ VV++ + G+ L C HLNL E++YFGL ++ + WL+ K Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60 Query: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121 I KQV+ F F VKF+P DP L E++TRY LQ+++D+ GRLPCS AL+ Sbjct: 61 EIKKQVRGVPWN-FTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119 Query: 122 VSHILQSELGDFHEETDR-KHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLD 179 S+ +QSELGD+ E +++ + PNQ LE K+M H+ + +PA++D+ L+ Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179 Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239 A+KL MYG+ H A D EG+ I L V G+LV + +IN F W K+ K+S+KR F Sbjct: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239 Query: 240 IKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSF 299 IK+ + T+ F + S A K WK CVE+H FFRL+ + PK+ + GS F Sbjct: 240 IKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLT-STDTIPKSKFLALGSKF 298 Query: 300 RYSGRTQRQ 308 RYSGRTQ Q Sbjct: 299 RYSGRTQAQ 307 >gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) isoform 3 [Homo sapiens] Length = 588 Score = 234 bits (597), Expect = 2e-61 Identities = 128/309 (41%), Positives = 182/309 (58%), Gaps = 4/309 (1%) Query: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61 +H KV LDD+ VV++ + G+ L C HLNL E++YFGL ++ + WL+ K Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60 Query: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121 I KQV+ F F VKF+P DP L E++TRY LQ+++D+ GRLPCS AL+ Sbjct: 61 EIKKQVRGVPWN-FTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119 Query: 122 VSHILQSELGDFHEETDR-KHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLD 179 S+ +QSELGD+ E +++ + PNQ LE K+M H+ + +PA++D+ L+ Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179 Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239 A+KL MYG+ H A D EG+ I L V G+LV + +IN F W K+ K+S+KR F Sbjct: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239 Query: 240 IKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSF 299 IK+ + T+ F + S A K WK CVE+H FFRL+ + PK+ + GS F Sbjct: 240 IKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLT-STDTIPKSKFLALGSKF 298 Query: 300 RYSGRTQRQ 308 RYSGRTQ Q Sbjct: 299 RYSGRTQAQ 307 >gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] Length = 570 Score = 208 bits (530), Expect = 1e-53 Identities = 123/339 (36%), Positives = 189/339 (55%), Gaps = 10/339 (2%) Query: 6 VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITK 65 V+ LDDS+ + + + G+ LF+L C HLNL EK+YFG+ F WLE K + K Sbjct: 21 VRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVK 80 Query: 66 QVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHI 125 Q+++ F VKF+P DP L+EE+TRYL LQIK+DL GRL C + AL+ ++I Sbjct: 81 QLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYI 140 Query: 126 LQSELGDFHE-ETDRKHLAQTRYLP-NQDCLEGKIMHFHQKHI-GRSPAESDILLLDIAR 182 LQ+E+GD+ + + ++ ++ P + + LE KI H+ + G++PA S++ L A+ Sbjct: 141 LQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQ 200 Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242 L+ YG+ PHP D G LA G +VL+GN +++ W ++ KL F+ K F L Sbjct: 201 TLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFY--L 258 Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRL--SEEPKSKPKTLLCSKGSSFR 300 + + K L + + +ACK WK +E AF++L S + ++ + L KGS FR Sbjct: 259 YVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFR 318 Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRS 339 YSGR ++++E K +K P E H R C S Sbjct: 319 YSGRVAKEVMESSAK--IKREPPE-IHRAGMVPSRSCPS 354 >gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) isoform 1 [Homo sapiens] Length = 775 Score = 197 bits (500), Expect = 4e-50 Identities = 119/308 (38%), Positives = 168/308 (54%), Gaps = 10/308 (3%) Query: 9 LDDSQKIFVVDQKSSGKALFNLSCS------HLNLAEKEYFGLEFCSHSGNNVWLELLKP 62 L++ KI V ++ KA L S H N+ K + WL+ K Sbjct: 176 LEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVETWLDSAKE 235 Query: 63 ITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMV 122 I KQV+ F F VKF+P DP L E++TRY LQ+++D+ GRLPCS AL+ Sbjct: 236 IKKQVRGVPWN-FTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 294 Query: 123 SHILQSELGDFHEETDR-KHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDI 180 S+ +QSELGD+ E +++ + PNQ LE K+M H+ + +PA++D+ L+ Sbjct: 295 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 354 Query: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240 A+KL MYG+ H A D EG+ I L V G+LV + +IN F W K+ K+S+KR F I Sbjct: 355 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 414 Query: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300 K+ + T+ F + S A K WK CVE+H FFRL+ + PK+ + GS FR Sbjct: 415 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLT-STDTIPKSKFLALGSKFR 473 Query: 301 YSGRTQRQ 308 YSGRTQ Q Sbjct: 474 YSGRTQAQ 481 >gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform 1 [Homo sapiens] Length = 518 Score = 193 bits (490), Expect = 5e-49 Identities = 132/414 (31%), Positives = 206/414 (49%), Gaps = 29/414 (7%) Query: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61 L+ +V LD ++ + + + G+ LF+ HL+L E +YFGL+F + WL+ K Sbjct: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144 Query: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121 PI KQ+K F VK++ +P +LREE TRYLF LQ++ D+ G+L C + Sbjct: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204 Query: 122 VSHILQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLD 179 + LQ+ELG+ E + +++ R++PNQ + +E I ++ G+SPA++++ L+ Sbjct: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264 Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239 A+ L+MYG+ H +G + L + G+L+ G KI F W KI K+ FK+ Sbjct: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL- 323 Query: 240 IKLHANILVLCKD---------TLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKP-K 289 LV+ +D T F + S CK WK VE+HAFFRL SK + Sbjct: 324 ------TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNR 377 Query: 290 TLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFER---KHYPSQYHERQCRSSPDLLSD 346 + GS FR+SGRT+ Q R R + FER K YPS+ H S+P + + Sbjct: 378 SDFIRLGSRFRFSGRTEYQATHGSRLRRTST--FERKPSKRYPSRRHSTFKASNPVIAAQ 435 Query: 347 VSKQVEDLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEA 400 + + Y Y+ N +H S+P N + +F + H K A Sbjct: 436 LCSKTNPEVHNYQPQYHPN---IHPSQPRWHPHSPN--VRPSFQDDRSHWKASA 484 >gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform 2 [Homo sapiens] Length = 900 Score = 192 bits (489), Expect = 7e-49 Identities = 127/388 (32%), Positives = 198/388 (51%), Gaps = 27/388 (6%) Query: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61 L+ +V LD ++ + + + G+ LF+ HL+L E +YFGL+F + WL+ K Sbjct: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144 Query: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121 PI KQ+K F VK++ +P +LREE TRYLF LQ++ D+ G+L C + Sbjct: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204 Query: 122 VSHILQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLD 179 + LQ+ELG+ E + +++ R++PNQ + +E I ++ G+SPA++++ L+ Sbjct: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264 Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239 A+ L+MYG+ H +G + L + G+L+ G KI F W KI K+ FK+ Sbjct: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL- 323 Query: 240 IKLHANILVLCKD---------TLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKP-K 289 LV+ +D T F + S CK WK VE+HAFFRL SK + Sbjct: 324 ------TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNR 377 Query: 290 TLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFER---KHYPSQYHERQCRSSPDLLSD 346 + GS FR+SGRT+ Q R R + FER K YPS+ H S+P + + Sbjct: 378 SDFIRLGSRFRFSGRTEYQATHGSRLRRTST--FERKPSKRYPSRRHSTFKASNPVIAAQ 435 Query: 347 VSKQVEDLRLAYGGGYYQNVNGVHASEP 374 + + Y Y+ N +H S+P Sbjct: 436 LCSKTNPEVHNYQPQYHPN---IHPSQP 460 >gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo sapiens] Length = 733 Score = 189 bits (480), Expect = 8e-48 Identities = 130/376 (34%), Positives = 198/376 (52%), Gaps = 32/376 (8%) Query: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64 +V LD + + +K+ G+ LF+ HL+L E +YFGL F + WL+ K I Sbjct: 46 RVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSIK 105 Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124 KQVK VKF+ +P +LREELTRYLF LQ+K+D+ G+L C + + ++ Sbjct: 106 KQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQLAAY 165 Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLDIAR 182 LQ+ELGD+ E + +++ R++P Q + +E I +++ G++PA+++ L+ A+ Sbjct: 166 NLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLNKAK 225 Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242 L+MYG+ H +G L + GVLV G+TKI F W KI +L FK+ Sbjct: 226 WLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKL---- 281 Query: 243 HANILVLCKD---------TLEFTMASRDACKAFWKTCVEYHAFFRL-SEEPKSKPKTLL 292 LV+ +D T F + ACK WK VE+HAFFRL KS ++ Sbjct: 282 ---TLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSHRSGF 338 Query: 293 CSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQ------CRSSPDLLS- 345 GS FRYSG+T+ Q + + R S FER+ PS+ + R+ C + P+ LS Sbjct: 339 IRLGSRFRYSGKTEYQTTKTNKARR--STSFERR--PSKRYSRRTLQMKACATKPEELSV 394 Query: 346 --DVSKQVEDLRLAYG 359 +VS Q + A+G Sbjct: 395 HNNVSTQSNGSQQAWG 410 >gi|117500790 FERM domain containing 3 [Homo sapiens] Length = 597 Score = 182 bits (463), Expect = 7e-46 Identities = 139/459 (30%), Positives = 219/459 (47%), Gaps = 27/459 (5%) Query: 6 VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITK 65 ++ LDDS+ + +++ G+ L + C++ +L EK+YFG+ + WLE K I K Sbjct: 36 IRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFK 95 Query: 66 QVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHI 125 Q+K F VKF+P +P ++EELTRYL LQIK+D+ GRL CS + A + + I Sbjct: 96 QMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACI 155 Query: 126 LQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHI-GRSPAESDILLLDIAR 182 +Q+ELGD+ +E ++++ P Q LE KI+ H+ + G+SP ++ LL A Sbjct: 156 VQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAH 215 Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242 L+ YG+ PHP D G L G +V +GN +I+ W + KL F+ K F + Sbjct: 216 TLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYV-- 273 Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRL--SEEPKSKPKTLLCSKGSSFR 300 K L F ++ ACK WK VE AF++ S + K+ + + KGS FR Sbjct: 274 -IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSRFR 332 Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSS--------PDLLSDVSKQVE 352 YSG+ ++++E K + + R + LL S+Q E Sbjct: 333 YSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPSPSEQEE 392 Query: 353 DLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQ---SQ 409 +L L G + N S P++ S +A E E K + +P + + + Sbjct: 393 ELPLGEGVPLPKEEN---ISAPLISSSPVKAAREYEDPPSEEEDKIKEEPLTISELVYNP 449 Query: 410 SSSSFPFIYMDPVFNTEPNPNPD-PRDIFSERSSLSSFQ 447 S+S P PV + E + D P + ER SF+ Sbjct: 450 SASLLP----TPVDDDEIDMLFDCPSRLELEREDTDSFE 484 >gi|223941879 protein tyrosine phosphatase, non-receptor type 3 isoform 2 [Homo sapiens] Length = 868 Score = 174 bits (440), Expect = 3e-43 Identities = 96/278 (34%), Positives = 152/278 (54%), Gaps = 5/278 (1%) Query: 6 VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNV-WLELLKPIT 64 + FLD + F V ++ +G+ L ++ +HL + EKEYFGL+ S ++ WLE K I Sbjct: 33 IHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIR 92 Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124 KQ+K F V+FF DP L++E TR+L+ LQ+K D+ GRL C N ++ S+ Sbjct: 93 KQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASY 152 Query: 125 ILQSELGDFHEETDRK-HLAQTRYLP--NQDCLEGKIMHFHQKHIGRSPAESDILLLDIA 181 +QS GD++ +L+ + ++P N+D L K+ H++H G +E++ ++IA Sbjct: 153 AVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLT-KVESLHEQHSGLKQSEAESCYINIA 211 Query: 182 RKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIK 241 R LD YG+ H D + + + +A GV V R + + W I K+SFKRK F I Sbjct: 212 RTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIH 271 Query: 242 LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFR 279 + + F M + +CK WK+CVE+H FF+ Sbjct: 272 QRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQ 309 >gi|223941876 protein tyrosine phosphatase, non-receptor type 3 isoform 1 [Homo sapiens] Length = 913 Score = 174 bits (440), Expect = 3e-43 Identities = 96/278 (34%), Positives = 152/278 (54%), Gaps = 5/278 (1%) Query: 6 VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNV-WLELLKPIT 64 + FLD + F V ++ +G+ L ++ +HL + EKEYFGL+ S ++ WLE K I Sbjct: 33 IHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIR 92 Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124 KQ+K F V+FF DP L++E TR+L+ LQ+K D+ GRL C N ++ S+ Sbjct: 93 KQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASY 152 Query: 125 ILQSELGDFHEETDRK-HLAQTRYLP--NQDCLEGKIMHFHQKHIGRSPAESDILLLDIA 181 +QS GD++ +L+ + ++P N+D L K+ H++H G +E++ ++IA Sbjct: 153 AVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLT-KVESLHEQHSGLKQSEAESCYINIA 211 Query: 182 RKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIK 241 R LD YG+ H D + + + +A GV V R + + W I K+SFKRK F I Sbjct: 212 RTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIH 271 Query: 242 LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFR 279 + + F M + +CK WK+CVE+H FF+ Sbjct: 272 QRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQ 309 >gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] Length = 686 Score = 172 bits (436), Expect = 1e-42 Identities = 105/324 (32%), Positives = 168/324 (51%), Gaps = 23/324 (7%) Query: 3 HLKVQFLDDSQKIFVVDQK-----SSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWL 57 + +V LD+S+ Q+ + G + + H+NL E +YFGL +C S WL Sbjct: 12 YCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWL 71 Query: 58 ELLKPITKQ---VKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCS 114 + K + + + F +KF+ DP L+EE+TRY F LQ+K+D+ GRLPC Sbjct: 72 DPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCP 131 Query: 115 DNCTALMVSHILQSELGDFHE-ETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAE 172 N A + ++ +QSELGD+ + ++++ R++P+Q + LE I H+ +G+ P+E Sbjct: 132 VNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSE 191 Query: 173 SDILLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLS 232 +++ L A+ L+MYG+ HP + L + +GV+V + ++ + W +I K+ Sbjct: 192 AELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVH 251 Query: 233 FKRKHFLIKLHANILVLCKDTLE----FTMASRDACKAFWKTCVEYHAFFRLSEEPKSKP 288 FK F ++ VL KD E F S+ ACK WK VE+H FFR+ E + Sbjct: 252 FKETQFELR------VLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSL 305 Query: 289 KTLLCSKGS---SFRYSGRTQRQL 309 L GS RYSGRT Q+ Sbjct: 306 SRKLSKFGSIRYKHRYSGRTALQM 329 >gi|4506467 radixin [Homo sapiens] Length = 583 Score = 125 bits (313), Expect = 2e-28 Identities = 83/283 (29%), Positives = 142/283 (50%), Gaps = 32/283 (11%) Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69 D++ F + ++GK LF+ + L E +FGL++ G + WL+L K +T+Q VK Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKK 72 Query: 70 PKEIVFKFMVKFFPVDPG-HLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128 + FKF KFFP D L +E+T+ LF LQ+K+ + + C L+ S+ +Q+ Sbjct: 73 ENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQA 132 Query: 129 ELGDFHEETDRK-HLAQTRYLP---------NQDCLEGKIMHFHQKHIGRSPAESDILLL 178 + GD+++E + +LA R LP ++ E +I ++H++H G +S + L Sbjct: 133 KYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYL 192 Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINT---FNWAKIRKLSFKR 235 IA+ L+MYG+ + +G ++ L V +G+ + + K+ F W++IR +SF Sbjct: 193 KIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFND 252 Query: 236 KHFLIK-----------------LHANILVLCKDTLEFTMASR 261 K F+IK ++ IL LC E M R Sbjct: 253 KKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRR 295 >gi|4505257 moesin [Homo sapiens] Length = 577 Score = 124 bits (310), Expect = 4e-28 Identities = 82/283 (28%), Positives = 142/283 (50%), Gaps = 32/283 (11%) Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69 D++ F + ++GK LF+ + L E +FGL++ G + WL+L K +T Q V+ Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRK 72 Query: 70 PKEIVFKFMVKFFPVDPG-HLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128 ++FKF KF+P D L +++T+ LF LQ+K+ + + C L+ S+ +QS Sbjct: 73 ESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQS 132 Query: 129 ELGDFHEETDRK-HLAQTRYLP---------NQDCLEGKIMHFHQKHIGRSPAESDILLL 178 + GDF++E + +LA + LP N+D E +I +H++H G ++ + L Sbjct: 133 KYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYL 192 Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINT---FNWAKIRKLSFKR 235 IA+ L+MYG+ + +G ++ L V +G+ + N ++ F W++IR +SF Sbjct: 193 KIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFND 252 Query: 236 KHFLIK-----------------LHANILVLCKDTLEFTMASR 261 K F+IK ++ IL LC E M R Sbjct: 253 KKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRR 295 >gi|150418005 protein tyrosine phosphatase, non-receptor type 21 [Homo sapiens] Length = 1174 Score = 122 bits (307), Expect = 9e-28 Identities = 78/288 (27%), Positives = 139/288 (48%), Gaps = 15/288 (5%) Query: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64 ++Q L++ F + +S+G+ L L E YF L + + W++L KP+ Sbjct: 26 RIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLK 85 Query: 65 KQV-KNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVS 123 KQ+ K E F V F+ L++E+TRY + LQ+KKD+ G +PC+ + Sbjct: 86 KQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAG 145 Query: 124 HILQSELGDFHEETDRKHLAQ-----TRYLPNQDCLE---GKIMHFHQKHIGRSPAESDI 175 +Q++ GDF + + L + +L ++ LE K+ HQK+ G + ++++ Sbjct: 146 LAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDAEM 205 Query: 176 LLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN-TFNWAKIRKLSFK 234 L + ++D YG +PA D +G I + G+ V N + F W I +S Sbjct: 206 LYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHN 265 Query: 235 RKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSE 282 + F ++L AN ++T++F + K W+ CV H F+RL++ Sbjct: 266 KSFFALEL-AN----KEETIQFQTEDMETAKYIWRLCVARHKFYRLNQ 308 >gi|161702986 ezrin [Homo sapiens] Length = 586 Score = 117 bits (292), Expect = 5e-26 Identities = 85/322 (26%), Positives = 155/322 (48%), Gaps = 19/322 (5%) Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69 D++ F + ++GK LF+ + L E YFGL + + G WL+L K ++ Q V+ Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72 Query: 70 PKEIVFKFMVKFFPVDPG-HLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128 + FKF KF+P D L +++T+ LF LQ+K+ + + C L+ S+ +Q+ Sbjct: 73 ENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQA 132 Query: 129 ELGDFHEETDRK-HLAQTRYLP---------NQDCLEGKIMHFHQKHIGRSPAESDILLL 178 + GD+++E + +L+ R +P +D E +I +H +H G + + L Sbjct: 133 KFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYL 192 Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINT---FNWAKIRKLSFKR 235 IA+ L+MYGI + +G + L V +G+ + + K+ F W++IR +SF Sbjct: 193 KIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFND 252 Query: 236 KHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSK 295 K F+IK I D + + R K + C+ H + +P + + ++ Sbjct: 253 KKFVIK---PIDKKAPDFVFYAPRLR-INKRILQLCMGNHELYMRRRKPDTIEVQQMKAQ 308 Query: 296 GSSFRYSGRTQRQLLEYGRKGR 317 ++ + +RQ LE +K R Sbjct: 309 AREEKHQKQLERQQLETEKKRR 330 >gi|21614499 ezrin [Homo sapiens] Length = 586 Score = 117 bits (292), Expect = 5e-26 Identities = 85/322 (26%), Positives = 155/322 (48%), Gaps = 19/322 (5%) Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69 D++ F + ++GK LF+ + L E YFGL + + G WL+L K ++ Q V+ Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72 Query: 70 PKEIVFKFMVKFFPVDPG-HLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128 + FKF KF+P D L +++T+ LF LQ+K+ + + C L+ S+ +Q+ Sbjct: 73 ENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQA 132 Query: 129 ELGDFHEETDRK-HLAQTRYLP---------NQDCLEGKIMHFHQKHIGRSPAESDILLL 178 + GD+++E + +L+ R +P +D E +I +H +H G + + L Sbjct: 133 KFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYL 192 Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINT---FNWAKIRKLSFKR 235 IA+ L+MYGI + +G + L V +G+ + + K+ F W++IR +SF Sbjct: 193 KIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFND 252 Query: 236 KHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSK 295 K F+IK I D + + R K + C+ H + +P + + ++ Sbjct: 253 KKFVIK---PIDKKAPDFVFYAPRLR-INKRILQLCMGNHELYMRRRKPDTIEVQQMKAQ 308 Query: 296 GSSFRYSGRTQRQLLEYGRKGR 317 ++ + +RQ LE +K R Sbjct: 309 AREEKHQKQLERQQLETEKKRR 330 >gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] Length = 590 Score = 111 bits (277), Expect = 3e-24 Identities = 78/284 (27%), Positives = 141/284 (49%), Gaps = 22/284 (7%) Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69 D++ F + K GK LF+L C L L E +FGL++ + WL++ K + V Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY-TIKDTVAWLKMDKKVLDHDVSK 88 Query: 70 PKEIVFKFMVKFFPVDPGH-LREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128 + + F F+ KF+P + L +E+T++LF LQ+KK + ++ C + L+ S+ +Q+ Sbjct: 89 EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148 Query: 129 ELGDFHEETDRK-HLAQTRYLPNQ---------DCLEGKIMHFHQKHIGRSPAESDILLL 178 + GD+ ++ LAQ LP + + E +I ++ +H GR+ E+++ L Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208 Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN---TFNWAKIRKLSFKR 235 IA+ L+MYG+ + +G ++ L V +G+ + ++ +F W +IR +S+ Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268 Query: 236 KHFLIK-LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFF 278 K F IK L I D +F + K + C+ H F Sbjct: 269 KEFTIKPLDKKI-----DVFKFNSSKLRVNKLILQLCIGNHDLF 307 >gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] Length = 590 Score = 111 bits (277), Expect = 3e-24 Identities = 78/284 (27%), Positives = 141/284 (49%), Gaps = 22/284 (7%) Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69 D++ F + K GK LF+L C L L E +FGL++ + WL++ K + V Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY-TIKDTVAWLKMDKKVLDHDVSK 88 Query: 70 PKEIVFKFMVKFFPVDPGH-LREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128 + + F F+ KF+P + L +E+T++LF LQ+KK + ++ C + L+ S+ +Q+ Sbjct: 89 EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148 Query: 129 ELGDFHEETDRK-HLAQTRYLPNQ---------DCLEGKIMHFHQKHIGRSPAESDILLL 178 + GD+ ++ LAQ LP + + E +I ++ +H GR+ E+++ L Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208 Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN---TFNWAKIRKLSFKR 235 IA+ L+MYG+ + +G ++ L V +G+ + ++ +F W +IR +S+ Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268 Query: 236 KHFLIK-LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFF 278 K F IK L I D +F + K + C+ H F Sbjct: 269 KEFTIKPLDKKI-----DVFKFNSSKLRVNKLILQLCIGNHDLF 307 >gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] Length = 590 Score = 111 bits (277), Expect = 3e-24 Identities = 78/284 (27%), Positives = 141/284 (49%), Gaps = 22/284 (7%) Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69 D++ F + K GK LF+L C L L E +FGL++ + WL++ K + V Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY-TIKDTVAWLKMDKKVLDHDVSK 88 Query: 70 PKEIVFKFMVKFFPVDPGH-LREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128 + + F F+ KF+P + L +E+T++LF LQ+KK + ++ C + L+ S+ +Q+ Sbjct: 89 EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148 Query: 129 ELGDFHEETDRK-HLAQTRYLPNQ---------DCLEGKIMHFHQKHIGRSPAESDILLL 178 + GD+ ++ LAQ LP + + E +I ++ +H GR+ E+++ L Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208 Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN---TFNWAKIRKLSFKR 235 IA+ L+MYG+ + +G ++ L V +G+ + ++ +F W +IR +S+ Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268 Query: 236 KHFLIK-LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFF 278 K F IK L I D +F + K + C+ H F Sbjct: 269 KEFTIKPLDKKI-----DVFKFNSSKLRVNKLILQLCIGNHDLF 307 >gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] Length = 595 Score = 111 bits (277), Expect = 3e-24 Identities = 78/284 (27%), Positives = 141/284 (49%), Gaps = 22/284 (7%) Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69 D++ F + K GK LF+L C L L E +FGL++ + WL++ K + V Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY-TIKDTVAWLKMDKKVLDHDVSK 88 Query: 70 PKEIVFKFMVKFFPVDPGH-LREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128 + + F F+ KF+P + L +E+T++LF LQ+KK + ++ C + L+ S+ +Q+ Sbjct: 89 EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148 Query: 129 ELGDFHEETDRK-HLAQTRYLPNQ---------DCLEGKIMHFHQKHIGRSPAESDILLL 178 + GD+ ++ LAQ LP + + E +I ++ +H GR+ E+++ L Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208 Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN---TFNWAKIRKLSFKR 235 IA+ L+MYG+ + +G ++ L V +G+ + ++ +F W +IR +S+ Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268 Query: 236 KHFLIK-LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFF 278 K F IK L I D +F + K + C+ H F Sbjct: 269 KEFTIKPLDKKI-----DVFKFNSSKLRVNKLILQLCIGNHDLF 307 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.134 0.398 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 28,690,277 Number of Sequences: 37866 Number of extensions: 1366876 Number of successful extensions: 3662 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 50 Number of HSP's successfully gapped in prelim test: 17 Number of HSP's that attempted gapping in prelim test: 3478 Number of HSP's gapped (non-prelim): 79 length of query: 714 length of database: 18,247,518 effective HSP length: 109 effective length of query: 605 effective length of database: 14,120,124 effective search space: 8542675020 effective search space used: 8542675020 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.