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Search of human proteins with 34916000
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34916000 FERM domain containing 7 [Homo sapiens]
(714 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34916000 FERM domain containing 7 [Homo sapiens] 1452 0.0
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 431 e-120
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 388 e-108
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 243 4e-64
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 240 3e-63
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 239 5e-63
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 236 5e-62
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 236 7e-62
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 236 7e-62
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 236 7e-62
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 234 2e-61
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 234 2e-61
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 208 1e-53
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 197 4e-50
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 193 5e-49
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 192 7e-49
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 189 8e-48
gi|117500790 FERM domain containing 3 [Homo sapiens] 182 7e-46
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 174 3e-43
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 174 3e-43
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 172 1e-42
gi|4506467 radixin [Homo sapiens] 125 2e-28
gi|4505257 moesin [Homo sapiens] 124 4e-28
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 122 9e-28
gi|161702986 ezrin [Homo sapiens] 117 5e-26
gi|21614499 ezrin [Homo sapiens] 117 5e-26
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 111 3e-24
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 111 3e-24
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 111 3e-24
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 111 3e-24
>gi|34916000 FERM domain containing 7 [Homo sapiens]
Length = 714
Score = 1452 bits (3758), Expect = 0.0
Identities = 714/714 (100%), Positives = 714/714 (100%)
Query: 1 MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELL 60
MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELL
Sbjct: 1 MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELL 60
Query: 61 KPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTAL 120
KPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTAL
Sbjct: 61 KPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTAL 120
Query: 121 MVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDI 180
MVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDI
Sbjct: 121 MVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDI 180
Query: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240
ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI
Sbjct: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240
Query: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300
KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR
Sbjct: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300
Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGG 360
YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGG
Sbjct: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGG 360
Query: 361 GYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYMD 420
GYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYMD
Sbjct: 361 GYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYMD 420
Query: 421 PVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVPY 480
PVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVPY
Sbjct: 421 PVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVPY 480
Query: 481 IPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVEPTAMKPAERSPRNIRM 540
IPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVEPTAMKPAERSPRNIRM
Sbjct: 481 IPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVEPTAMKPAERSPRNIRM 540
Query: 541 KSFQQDLQVLQEAIARTSGRSNINVGLEEEDPNLEDAFVCNIQEQTPKRSQSQSDMKTIR 600
KSFQQDLQVLQEAIARTSGRSNINVGLEEEDPNLEDAFVCNIQEQTPKRSQSQSDMKTIR
Sbjct: 541 KSFQQDLQVLQEAIARTSGRSNINVGLEEEDPNLEDAFVCNIQEQTPKRSQSQSDMKTIR 600
Query: 601 FPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILKP 660
FPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILKP
Sbjct: 601 FPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILKP 660
Query: 661 DYYALYGKEIRSPMARIRLSSGSLQLDEEDEDAYFNTPTAEDRTSLKPCNYFLA 714
DYYALYGKEIRSPMARIRLSSGSLQLDEEDEDAYFNTPTAEDRTSLKPCNYFLA
Sbjct: 661 DYYALYGKEIRSPMARIRLSSGSLQLDEEDEDAYFNTPTAEDRTSLKPCNYFLA 714
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 431 bits (1107), Expect = e-120
Identities = 231/443 (52%), Positives = 299/443 (67%), Gaps = 22/443 (4%)
Query: 1 MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELL 60
++ +K+Q LDD+Q+ F V Q++ GK L + C+HLNL E +YFGLEF H VWL+LL
Sbjct: 39 LVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLL 98
Query: 61 KPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTAL 120
KPI KQ++ PK +V KF+VKFFP D L+EELTRYLF LQ+K+DLA GRL C+D AL
Sbjct: 99 KPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAAL 158
Query: 121 MVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDI 180
++SHI+QSE+GDF E DR+HLA+ +Y+P QD LE KI+ FH HIG++PAESD LL+I
Sbjct: 159 LISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEI 218
Query: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240
AR+L+MYGIR HPA D EG +I+LAVA+ G+LV +G TKIN FNWAK+RKLSFKRK FLI
Sbjct: 219 ARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLI 278
Query: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300
KL + +DTLEF MASRD CK+FWK CVE+HAFFRL EEPK KPK +L S+GSSFR
Sbjct: 279 KLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFR 338
Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHE-RQCRSSP-DLLSDVSKQ-VEDLRLA 357
+SGRTQ+Q+L+Y ++G K + FERKH S+ H R S P +L S+V +Q + L
Sbjct: 339 FSGRTQKQVLDYVKEGGHKKVQFERKH--SKIHSIRSLASQPTELNSEVLEQSQQSTSLT 396
Query: 358 YGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSK--PEADPTLLHQSQSSSSFP 415
+G G A P +S RR +V+ H P P Q+ ++S P
Sbjct: 397 FGEG---------AESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAP 447
Query: 416 F-----IYMDPVFNTEPNPNPDP 433
+ D ++P P P P
Sbjct: 448 TEEEEEVVKDRTQQSKPQP-PQP 469
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 388 bits (997), Expect = e-108
Identities = 187/327 (57%), Positives = 241/327 (73%), Gaps = 2/327 (0%)
Query: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
LHL+V+ LD++ +IF ++ K G+ L LNL E +YFG+EF + +WLE +K
Sbjct: 44 LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMK 103
Query: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
PI +Q++ PK +V + VKFFP DPG L+EE TRYLF LQ+K+DL RL C+D AL+
Sbjct: 104 PIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALL 163
Query: 122 VSHILQSELGDFHEETDRKHLAQTRYLPNQD-CLEGKIMHFHQKHIGRSPAESDILLLDI 180
SH+LQSE+GD+ E DR+HL YLP Q CLE KI+ FHQKH+G++PAESD +L+I
Sbjct: 164 TSHLLQSEIGDYDETLDREHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAESDFQVLEI 222
Query: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240
ARKL+MYGIR H ASD EG +I LAV+HMGVLV +G TKINTFNW+K+RKLSFKRK FLI
Sbjct: 223 ARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLI 282
Query: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300
KLH + +DTLEF + SRD CK FWK CVEYH FFRL ++PK K K + S+GSSFR
Sbjct: 283 KLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFR 342
Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKH 327
YSGRTQ+QL++Y + +K +P+ER+H
Sbjct: 343 YSGRTQKQLVDYFKDSGMKRIPYERRH 369
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 243 bits (620), Expect = 4e-64
Identities = 163/488 (33%), Positives = 244/488 (50%), Gaps = 30/488 (6%)
Query: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
+ KV LD S+ V+++S G+ LF+ C HLNL EK+YFGL + WL+ K
Sbjct: 110 MQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAK 169
Query: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
I KQV++ F F VKF+P DP L E++TRY LQ++ D+ GRLPCS AL+
Sbjct: 170 EIKKQVRSGAWH-FSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALL 228
Query: 122 VSHILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLD 179
S+ +QSELGD+ +E ++++ R+ PN LE K++ H+ H G +PAE+++ L+
Sbjct: 229 GSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLE 288
Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239
A+KL MYG+ H A D EG++I L V G+L+ R +IN F W K+ K+S+KR +F
Sbjct: 289 NAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFY 348
Query: 240 IKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSF 299
IK+ + T+ F + + A K WK CVE+H FFRL P++ PK L + GS F
Sbjct: 349 IKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLL-LPEAPPKKFL-TLGSKF 406
Query: 300 RYSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYG 359
RYSGRTQ Q R S +R P+ Y ER + + +V G
Sbjct: 407 RYSGRTQAQT-------RRASALIDR---PAPYFERSSSKRYTMSRSLDGEV-------G 449
Query: 360 GGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYM 419
G Y G+ + + A E E + K E + T + + P +
Sbjct: 450 TGQYATTKGISQTNLITTVTPEKKAEEERDEEEDKRRKGE-EVTPISAIRHEGKSPGLGT 508
Query: 420 DPVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVP 479
D + P+ + P +S + + CK + + Y ++ P + +D P
Sbjct: 509 DSCPLSPPSTHCAP-------TSPTELRRRCKENDCKLPGYEPSRAEHLPGEPALDSDGP 561
Query: 480 YIPCTGQQ 487
P G Q
Sbjct: 562 GRPYLGDQ 569
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 240 bits (613), Expect = 3e-63
Identities = 149/409 (36%), Positives = 217/409 (53%), Gaps = 17/409 (4%)
Query: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
+V LD S+ V++ G+ LF+L C HLNL EK+YFGL FC WL+ K I
Sbjct: 100 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 159
Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
KQ+++ F F VKF+P DP L E++TRY LQ++ D+ GRLPCS AL+ S+
Sbjct: 160 KQIRS-SPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 218
Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182
+Q+ELGD+ EE ++++ R+ PNQ LE +IM H+ + G +P E++I L+ A+
Sbjct: 219 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 278
Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
KL MYG+ H A D EG+ I L V G+L+ R +IN F W KI K+S+KR +F IK+
Sbjct: 279 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 338
Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302
+ T+ F + + + K WK C+E+H FFRL P+ PK L GS FRYS
Sbjct: 339 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL-VSPEPPPKGFLV-MGSKFRYS 396
Query: 303 GRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGGGY 362
GRTQ Q R S +R P+ + ER + + + +
Sbjct: 397 GRTQAQT-------RQASALIDR---PAPFFERSSSKRYTMSRSLDGAEFSRPASVSENH 446
Query: 363 YQNVNGVHASEPVLESRRRNSAL--EVTFATELEHSKPEADPTLLHQSQ 409
+G E +R+ A EV T+++ KPE + T H+ +
Sbjct: 447 DAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQE 495
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 239 bits (611), Expect = 5e-63
Identities = 131/306 (42%), Positives = 183/306 (59%), Gaps = 5/306 (1%)
Query: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
+V LD S+ V++ G+ LF+L C HLNL EK+YFGL FC WL+ K I
Sbjct: 38 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 97
Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
KQ+++ F F VKF+P DP L E++TRY LQ++ D+ GRLPCS AL+ S+
Sbjct: 98 KQIRS-SPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 156
Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182
+Q+ELGD+ EE ++++ R+ PNQ LE +IM H+ + G +P E++I L+ A+
Sbjct: 157 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 216
Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
KL MYG+ H A D EG+ I L V G+L+ R +IN F W KI K+S+KR +F IK+
Sbjct: 217 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 276
Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302
+ T+ F + + + K WK C+E+H FFRL P+ PK L GS FRYS
Sbjct: 277 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL-VSPEPPPKGFLV-MGSKFRYS 334
Query: 303 GRTQRQ 308
GRTQ Q
Sbjct: 335 GRTQAQ 340
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 236 bits (602), Expect = 5e-62
Identities = 131/326 (40%), Positives = 188/326 (57%), Gaps = 7/326 (2%)
Query: 6 VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNV-WLELLKPIT 64
+ LD++ + F V++ G+ L ++ HL+L E++YFGL+ S +N WL+ KPI
Sbjct: 33 ILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIR 92
Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
KQ+K F VKFF DP L+EE TRY + LQIK+D+ GRLPC N AL+ S
Sbjct: 93 KQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASF 152
Query: 125 ILQSELGDFHEETDRK-HLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLDIAR 182
+QSELGD+ + + +L+ ++PNQ E +I HQ+HIG SPAE++ L+ AR
Sbjct: 153 AVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNTAR 212
Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
L++YG+ H A D +I + V G+L+ + ++NTF W KI K+SFK K F I+L
Sbjct: 213 TLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFIQL 272
Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLC---SKGSSF 299
+ + L F M + ACK WK CVE+H FFRL + P K + GS F
Sbjct: 273 RKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRL-DRPLPPQKNFFAHYFTLGSKF 331
Query: 300 RYSGRTQRQLLEYGRKGRLKSLPFER 325
RY GRT+ Q ++YG++ K F R
Sbjct: 332 RYCGRTEVQSVQYGKEKANKDRVFAR 357
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 236 bits (601), Expect = 7e-62
Identities = 129/306 (42%), Positives = 183/306 (59%), Gaps = 4/306 (1%)
Query: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
KV LD ++ +++ + G+ LF+ C HLNL EK+YFGL F WL+ K I
Sbjct: 221 KVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIK 280
Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
+Q++N + F F VKF+P DP L E++TRY LQ+++D+A GRLPCS AL+ S+
Sbjct: 281 RQLRNLPWL-FTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSY 339
Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182
LQ+ELGD+ EE L++ ++ P Q LE K+ H+ H G SPA++D L+ A+
Sbjct: 340 TLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAK 399
Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
+L MYG+ H A D EG+ I L V G+L+ + +IN F W KI K+S+KR +F IK+
Sbjct: 400 RLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKV 459
Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302
L + T+ F + + A K WK CVE+H F+RL P+ PK + GS FRYS
Sbjct: 460 RPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL-VSPEQPPKAKFLTLGSKFRYS 518
Query: 303 GRTQRQ 308
GRTQ Q
Sbjct: 519 GRTQAQ 524
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 236 bits (601), Expect = 7e-62
Identities = 129/306 (42%), Positives = 183/306 (59%), Gaps = 4/306 (1%)
Query: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
KV LD ++ +++ + G+ LF+ C HLNL EK+YFGL F WL+ K I
Sbjct: 221 KVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIK 280
Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
+Q++N + F F VKF+P DP L E++TRY LQ+++D+A GRLPCS AL+ S+
Sbjct: 281 RQLRNLPWL-FTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSY 339
Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182
LQ+ELGD+ EE L++ ++ P Q LE K+ H+ H G SPA++D L+ A+
Sbjct: 340 TLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAK 399
Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
+L MYG+ H A D EG+ I L V G+L+ + +IN F W KI K+S+KR +F IK+
Sbjct: 400 RLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKV 459
Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302
L + T+ F + + A K WK CVE+H F+RL P+ PK + GS FRYS
Sbjct: 460 RPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL-VSPEQPPKAKFLTLGSKFRYS 518
Query: 303 GRTQRQ 308
GRTQ Q
Sbjct: 519 GRTQAQ 524
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 236 bits (601), Expect = 7e-62
Identities = 129/306 (42%), Positives = 183/306 (59%), Gaps = 4/306 (1%)
Query: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
KV LD ++ +++ + G+ LF+ C HLNL EK+YFGL F WL+ K I
Sbjct: 221 KVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIK 280
Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
+Q++N + F F VKF+P DP L E++TRY LQ+++D+A GRLPCS AL+ S+
Sbjct: 281 RQLRNLPWL-FTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSY 339
Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182
LQ+ELGD+ EE L++ ++ P Q LE K+ H+ H G SPA++D L+ A+
Sbjct: 340 TLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAK 399
Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
+L MYG+ H A D EG+ I L V G+L+ + +IN F W KI K+S+KR +F IK+
Sbjct: 400 RLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKV 459
Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302
L + T+ F + + A K WK CVE+H F+RL P+ PK + GS FRYS
Sbjct: 460 RPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL-VSPEQPPKAKFLTLGSKFRYS 518
Query: 303 GRTQRQ 308
GRTQ Q
Sbjct: 519 GRTQAQ 524
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 234 bits (597), Expect = 2e-61
Identities = 128/309 (41%), Positives = 182/309 (58%), Gaps = 4/309 (1%)
Query: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
+H KV LDD+ VV++ + G+ L C HLNL E++YFGL ++ + WL+ K
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
I KQV+ F F VKF+P DP L E++TRY LQ+++D+ GRLPCS AL+
Sbjct: 61 EIKKQVRGVPWN-FTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
Query: 122 VSHILQSELGDFHEETDR-KHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLD 179
S+ +QSELGD+ E +++ + PNQ LE K+M H+ + +PA++D+ L+
Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179
Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239
A+KL MYG+ H A D EG+ I L V G+LV + +IN F W K+ K+S+KR F
Sbjct: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239
Query: 240 IKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSF 299
IK+ + T+ F + S A K WK CVE+H FFRL+ + PK+ + GS F
Sbjct: 240 IKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLT-STDTIPKSKFLALGSKF 298
Query: 300 RYSGRTQRQ 308
RYSGRTQ Q
Sbjct: 299 RYSGRTQAQ 307
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 234 bits (597), Expect = 2e-61
Identities = 128/309 (41%), Positives = 182/309 (58%), Gaps = 4/309 (1%)
Query: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
+H KV LDD+ VV++ + G+ L C HLNL E++YFGL ++ + WL+ K
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
I KQV+ F F VKF+P DP L E++TRY LQ+++D+ GRLPCS AL+
Sbjct: 61 EIKKQVRGVPWN-FTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119
Query: 122 VSHILQSELGDFHEETDR-KHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLD 179
S+ +QSELGD+ E +++ + PNQ LE K+M H+ + +PA++D+ L+
Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179
Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239
A+KL MYG+ H A D EG+ I L V G+LV + +IN F W K+ K+S+KR F
Sbjct: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239
Query: 240 IKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSF 299
IK+ + T+ F + S A K WK CVE+H FFRL+ + PK+ + GS F
Sbjct: 240 IKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLT-STDTIPKSKFLALGSKF 298
Query: 300 RYSGRTQRQ 308
RYSGRTQ Q
Sbjct: 299 RYSGRTQAQ 307
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 208 bits (530), Expect = 1e-53
Identities = 123/339 (36%), Positives = 189/339 (55%), Gaps = 10/339 (2%)
Query: 6 VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITK 65
V+ LDDS+ + + + G+ LF+L C HLNL EK+YFG+ F WLE K + K
Sbjct: 21 VRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVK 80
Query: 66 QVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHI 125
Q+++ F VKF+P DP L+EE+TRYL LQIK+DL GRL C + AL+ ++I
Sbjct: 81 QLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYI 140
Query: 126 LQSELGDFHE-ETDRKHLAQTRYLP-NQDCLEGKIMHFHQKHI-GRSPAESDILLLDIAR 182
LQ+E+GD+ + + ++ ++ P + + LE KI H+ + G++PA S++ L A+
Sbjct: 141 LQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQ 200
Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
L+ YG+ PHP D G LA G +VL+GN +++ W ++ KL F+ K F L
Sbjct: 201 TLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFY--L 258
Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRL--SEEPKSKPKTLLCSKGSSFR 300
+ + K L + + +ACK WK +E AF++L S + ++ + L KGS FR
Sbjct: 259 YVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFR 318
Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRS 339
YSGR ++++E K +K P E H R C S
Sbjct: 319 YSGRVAKEVMESSAK--IKREPPE-IHRAGMVPSRSCPS 354
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 197 bits (500), Expect = 4e-50
Identities = 119/308 (38%), Positives = 168/308 (54%), Gaps = 10/308 (3%)
Query: 9 LDDSQKIFVVDQKSSGKALFNLSCS------HLNLAEKEYFGLEFCSHSGNNVWLELLKP 62
L++ KI V ++ KA L S H N+ K + WL+ K
Sbjct: 176 LEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVETWLDSAKE 235
Query: 63 ITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMV 122
I KQV+ F F VKF+P DP L E++TRY LQ+++D+ GRLPCS AL+
Sbjct: 236 IKKQVRGVPWN-FTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 294
Query: 123 SHILQSELGDFHEETDR-KHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDI 180
S+ +QSELGD+ E +++ + PNQ LE K+M H+ + +PA++D+ L+
Sbjct: 295 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 354
Query: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240
A+KL MYG+ H A D EG+ I L V G+LV + +IN F W K+ K+S+KR F I
Sbjct: 355 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 414
Query: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300
K+ + T+ F + S A K WK CVE+H FFRL+ + PK+ + GS FR
Sbjct: 415 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLT-STDTIPKSKFLALGSKFR 473
Query: 301 YSGRTQRQ 308
YSGRTQ Q
Sbjct: 474 YSGRTQAQ 481
>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
1 [Homo sapiens]
Length = 518
Score = 193 bits (490), Expect = 5e-49
Identities = 132/414 (31%), Positives = 206/414 (49%), Gaps = 29/414 (7%)
Query: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
L+ +V LD ++ + + + G+ LF+ HL+L E +YFGL+F + WL+ K
Sbjct: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
Query: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
PI KQ+K F VK++ +P +LREE TRYLF LQ++ D+ G+L C +
Sbjct: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
Query: 122 VSHILQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLD 179
+ LQ+ELG+ E + +++ R++PNQ + +E I ++ G+SPA++++ L+
Sbjct: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264
Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239
A+ L+MYG+ H +G + L + G+L+ G KI F W KI K+ FK+
Sbjct: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL- 323
Query: 240 IKLHANILVLCKD---------TLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKP-K 289
LV+ +D T F + S CK WK VE+HAFFRL SK +
Sbjct: 324 ------TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNR 377
Query: 290 TLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFER---KHYPSQYHERQCRSSPDLLSD 346
+ GS FR+SGRT+ Q R R + FER K YPS+ H S+P + +
Sbjct: 378 SDFIRLGSRFRFSGRTEYQATHGSRLRRTST--FERKPSKRYPSRRHSTFKASNPVIAAQ 435
Query: 347 VSKQVEDLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEA 400
+ + Y Y+ N +H S+P N + +F + H K A
Sbjct: 436 LCSKTNPEVHNYQPQYHPN---IHPSQPRWHPHSPN--VRPSFQDDRSHWKASA 484
>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
2 [Homo sapiens]
Length = 900
Score = 192 bits (489), Expect = 7e-49
Identities = 127/388 (32%), Positives = 198/388 (51%), Gaps = 27/388 (6%)
Query: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
L+ +V LD ++ + + + G+ LF+ HL+L E +YFGL+F + WL+ K
Sbjct: 85 LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144
Query: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
PI KQ+K F VK++ +P +LREE TRYLF LQ++ D+ G+L C +
Sbjct: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204
Query: 122 VSHILQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLD 179
+ LQ+ELG+ E + +++ R++PNQ + +E I ++ G+SPA++++ L+
Sbjct: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264
Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239
A+ L+MYG+ H +G + L + G+L+ G KI F W KI K+ FK+
Sbjct: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL- 323
Query: 240 IKLHANILVLCKD---------TLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKP-K 289
LV+ +D T F + S CK WK VE+HAFFRL SK +
Sbjct: 324 ------TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNR 377
Query: 290 TLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFER---KHYPSQYHERQCRSSPDLLSD 346
+ GS FR+SGRT+ Q R R + FER K YPS+ H S+P + +
Sbjct: 378 SDFIRLGSRFRFSGRTEYQATHGSRLRRTST--FERKPSKRYPSRRHSTFKASNPVIAAQ 435
Query: 347 VSKQVEDLRLAYGGGYYQNVNGVHASEP 374
+ + Y Y+ N +H S+P
Sbjct: 436 LCSKTNPEVHNYQPQYHPN---IHPSQP 460
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 189 bits (480), Expect = 8e-48
Identities = 130/376 (34%), Positives = 198/376 (52%), Gaps = 32/376 (8%)
Query: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
+V LD + + +K+ G+ LF+ HL+L E +YFGL F + WL+ K I
Sbjct: 46 RVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSIK 105
Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
KQVK VKF+ +P +LREELTRYLF LQ+K+D+ G+L C + + ++
Sbjct: 106 KQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQLAAY 165
Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLDIAR 182
LQ+ELGD+ E + +++ R++P Q + +E I +++ G++PA+++ L+ A+
Sbjct: 166 NLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLNKAK 225
Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
L+MYG+ H +G L + GVLV G+TKI F W KI +L FK+
Sbjct: 226 WLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKL---- 281
Query: 243 HANILVLCKD---------TLEFTMASRDACKAFWKTCVEYHAFFRL-SEEPKSKPKTLL 292
LV+ +D T F + ACK WK VE+HAFFRL KS ++
Sbjct: 282 ---TLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSHRSGF 338
Query: 293 CSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQ------CRSSPDLLS- 345
GS FRYSG+T+ Q + + R S FER+ PS+ + R+ C + P+ LS
Sbjct: 339 IRLGSRFRYSGKTEYQTTKTNKARR--STSFERR--PSKRYSRRTLQMKACATKPEELSV 394
Query: 346 --DVSKQVEDLRLAYG 359
+VS Q + A+G
Sbjct: 395 HNNVSTQSNGSQQAWG 410
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 182 bits (463), Expect = 7e-46
Identities = 139/459 (30%), Positives = 219/459 (47%), Gaps = 27/459 (5%)
Query: 6 VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITK 65
++ LDDS+ + +++ G+ L + C++ +L EK+YFG+ + WLE K I K
Sbjct: 36 IRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFK 95
Query: 66 QVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHI 125
Q+K F VKF+P +P ++EELTRYL LQIK+D+ GRL CS + A + + I
Sbjct: 96 QMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACI 155
Query: 126 LQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHI-GRSPAESDILLLDIAR 182
+Q+ELGD+ +E ++++ P Q LE KI+ H+ + G+SP ++ LL A
Sbjct: 156 VQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAH 215
Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
L+ YG+ PHP D G L G +V +GN +I+ W + KL F+ K F +
Sbjct: 216 TLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYV-- 273
Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRL--SEEPKSKPKTLLCSKGSSFR 300
K L F ++ ACK WK VE AF++ S + K+ + + KGS FR
Sbjct: 274 -IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSRFR 332
Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSS--------PDLLSDVSKQVE 352
YSG+ ++++E K + + R + LL S+Q E
Sbjct: 333 YSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPSPSEQEE 392
Query: 353 DLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQ---SQ 409
+L L G + N S P++ S +A E E K + +P + + +
Sbjct: 393 ELPLGEGVPLPKEEN---ISAPLISSSPVKAAREYEDPPSEEEDKIKEEPLTISELVYNP 449
Query: 410 SSSSFPFIYMDPVFNTEPNPNPD-PRDIFSERSSLSSFQ 447
S+S P PV + E + D P + ER SF+
Sbjct: 450 SASLLP----TPVDDDEIDMLFDCPSRLELEREDTDSFE 484
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 174 bits (440), Expect = 3e-43
Identities = 96/278 (34%), Positives = 152/278 (54%), Gaps = 5/278 (1%)
Query: 6 VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNV-WLELLKPIT 64
+ FLD + F V ++ +G+ L ++ +HL + EKEYFGL+ S ++ WLE K I
Sbjct: 33 IHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIR 92
Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
KQ+K F V+FF DP L++E TR+L+ LQ+K D+ GRL C N ++ S+
Sbjct: 93 KQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASY 152
Query: 125 ILQSELGDFHEETDRK-HLAQTRYLP--NQDCLEGKIMHFHQKHIGRSPAESDILLLDIA 181
+QS GD++ +L+ + ++P N+D L K+ H++H G +E++ ++IA
Sbjct: 153 AVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLT-KVESLHEQHSGLKQSEAESCYINIA 211
Query: 182 RKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIK 241
R LD YG+ H D + + + +A GV V R + + W I K+SFKRK F I
Sbjct: 212 RTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIH 271
Query: 242 LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFR 279
+ + F M + +CK WK+CVE+H FF+
Sbjct: 272 QRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQ 309
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 174 bits (440), Expect = 3e-43
Identities = 96/278 (34%), Positives = 152/278 (54%), Gaps = 5/278 (1%)
Query: 6 VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNV-WLELLKPIT 64
+ FLD + F V ++ +G+ L ++ +HL + EKEYFGL+ S ++ WLE K I
Sbjct: 33 IHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIR 92
Query: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
KQ+K F V+FF DP L++E TR+L+ LQ+K D+ GRL C N ++ S+
Sbjct: 93 KQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASY 152
Query: 125 ILQSELGDFHEETDRK-HLAQTRYLP--NQDCLEGKIMHFHQKHIGRSPAESDILLLDIA 181
+QS GD++ +L+ + ++P N+D L K+ H++H G +E++ ++IA
Sbjct: 153 AVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLT-KVESLHEQHSGLKQSEAESCYINIA 211
Query: 182 RKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIK 241
R LD YG+ H D + + + +A GV V R + + W I K+SFKRK F I
Sbjct: 212 RTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIH 271
Query: 242 LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFR 279
+ + F M + +CK WK+CVE+H FF+
Sbjct: 272 QRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQ 309
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 172 bits (436), Expect = 1e-42
Identities = 105/324 (32%), Positives = 168/324 (51%), Gaps = 23/324 (7%)
Query: 3 HLKVQFLDDSQKIFVVDQK-----SSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWL 57
+ +V LD+S+ Q+ + G + + H+NL E +YFGL +C S WL
Sbjct: 12 YCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWL 71
Query: 58 ELLKPITKQ---VKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCS 114
+ K + + + F +KF+ DP L+EE+TRY F LQ+K+D+ GRLPC
Sbjct: 72 DPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCP 131
Query: 115 DNCTALMVSHILQSELGDFHE-ETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAE 172
N A + ++ +QSELGD+ + ++++ R++P+Q + LE I H+ +G+ P+E
Sbjct: 132 VNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSE 191
Query: 173 SDILLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLS 232
+++ L A+ L+MYG+ HP + L + +GV+V + ++ + W +I K+
Sbjct: 192 AELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVH 251
Query: 233 FKRKHFLIKLHANILVLCKDTLE----FTMASRDACKAFWKTCVEYHAFFRLSEEPKSKP 288
FK F ++ VL KD E F S+ ACK WK VE+H FFR+ E +
Sbjct: 252 FKETQFELR------VLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSL 305
Query: 289 KTLLCSKGS---SFRYSGRTQRQL 309
L GS RYSGRT Q+
Sbjct: 306 SRKLSKFGSIRYKHRYSGRTALQM 329
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 125 bits (313), Expect = 2e-28
Identities = 83/283 (29%), Positives = 142/283 (50%), Gaps = 32/283 (11%)
Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
D++ F + ++GK LF+ + L E +FGL++ G + WL+L K +T+Q VK
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKK 72
Query: 70 PKEIVFKFMVKFFPVDPG-HLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
+ FKF KFFP D L +E+T+ LF LQ+K+ + + C L+ S+ +Q+
Sbjct: 73 ENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQA 132
Query: 129 ELGDFHEETDRK-HLAQTRYLP---------NQDCLEGKIMHFHQKHIGRSPAESDILLL 178
+ GD+++E + +LA R LP ++ E +I ++H++H G +S + L
Sbjct: 133 KYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYL 192
Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINT---FNWAKIRKLSFKR 235
IA+ L+MYG+ + +G ++ L V +G+ + + K+ F W++IR +SF
Sbjct: 193 KIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFND 252
Query: 236 KHFLIK-----------------LHANILVLCKDTLEFTMASR 261
K F+IK ++ IL LC E M R
Sbjct: 253 KKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRR 295
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 124 bits (310), Expect = 4e-28
Identities = 82/283 (28%), Positives = 142/283 (50%), Gaps = 32/283 (11%)
Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
D++ F + ++GK LF+ + L E +FGL++ G + WL+L K +T Q V+
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRK 72
Query: 70 PKEIVFKFMVKFFPVDPG-HLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
++FKF KF+P D L +++T+ LF LQ+K+ + + C L+ S+ +QS
Sbjct: 73 ESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQS 132
Query: 129 ELGDFHEETDRK-HLAQTRYLP---------NQDCLEGKIMHFHQKHIGRSPAESDILLL 178
+ GDF++E + +LA + LP N+D E +I +H++H G ++ + L
Sbjct: 133 KYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYL 192
Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINT---FNWAKIRKLSFKR 235
IA+ L+MYG+ + +G ++ L V +G+ + N ++ F W++IR +SF
Sbjct: 193 KIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFND 252
Query: 236 KHFLIK-----------------LHANILVLCKDTLEFTMASR 261
K F+IK ++ IL LC E M R
Sbjct: 253 KKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRR 295
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 122 bits (307), Expect = 9e-28
Identities = 78/288 (27%), Positives = 139/288 (48%), Gaps = 15/288 (5%)
Query: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
++Q L++ F + +S+G+ L L E YF L + + W++L KP+
Sbjct: 26 RIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLK 85
Query: 65 KQV-KNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVS 123
KQ+ K E F V F+ L++E+TRY + LQ+KKD+ G +PC+ +
Sbjct: 86 KQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAG 145
Query: 124 HILQSELGDFHEETDRKHLAQ-----TRYLPNQDCLE---GKIMHFHQKHIGRSPAESDI 175
+Q++ GDF + + L + +L ++ LE K+ HQK+ G + ++++
Sbjct: 146 LAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDAEM 205
Query: 176 LLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN-TFNWAKIRKLSFK 234
L + ++D YG +PA D +G I + G+ V N + F W I +S
Sbjct: 206 LYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHN 265
Query: 235 RKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSE 282
+ F ++L AN ++T++F + K W+ CV H F+RL++
Sbjct: 266 KSFFALEL-AN----KEETIQFQTEDMETAKYIWRLCVARHKFYRLNQ 308
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 117 bits (292), Expect = 5e-26
Identities = 85/322 (26%), Positives = 155/322 (48%), Gaps = 19/322 (5%)
Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
D++ F + ++GK LF+ + L E YFGL + + G WL+L K ++ Q V+
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72
Query: 70 PKEIVFKFMVKFFPVDPG-HLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
+ FKF KF+P D L +++T+ LF LQ+K+ + + C L+ S+ +Q+
Sbjct: 73 ENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQA 132
Query: 129 ELGDFHEETDRK-HLAQTRYLP---------NQDCLEGKIMHFHQKHIGRSPAESDILLL 178
+ GD+++E + +L+ R +P +D E +I +H +H G + + L
Sbjct: 133 KFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYL 192
Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINT---FNWAKIRKLSFKR 235
IA+ L+MYGI + +G + L V +G+ + + K+ F W++IR +SF
Sbjct: 193 KIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFND 252
Query: 236 KHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSK 295
K F+IK I D + + R K + C+ H + +P + + ++
Sbjct: 253 KKFVIK---PIDKKAPDFVFYAPRLR-INKRILQLCMGNHELYMRRRKPDTIEVQQMKAQ 308
Query: 296 GSSFRYSGRTQRQLLEYGRKGR 317
++ + +RQ LE +K R
Sbjct: 309 AREEKHQKQLERQQLETEKKRR 330
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 117 bits (292), Expect = 5e-26
Identities = 85/322 (26%), Positives = 155/322 (48%), Gaps = 19/322 (5%)
Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
D++ F + ++GK LF+ + L E YFGL + + G WL+L K ++ Q V+
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72
Query: 70 PKEIVFKFMVKFFPVDPG-HLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
+ FKF KF+P D L +++T+ LF LQ+K+ + + C L+ S+ +Q+
Sbjct: 73 ENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQA 132
Query: 129 ELGDFHEETDRK-HLAQTRYLP---------NQDCLEGKIMHFHQKHIGRSPAESDILLL 178
+ GD+++E + +L+ R +P +D E +I +H +H G + + L
Sbjct: 133 KFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYL 192
Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINT---FNWAKIRKLSFKR 235
IA+ L+MYGI + +G + L V +G+ + + K+ F W++IR +SF
Sbjct: 193 KIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFND 252
Query: 236 KHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSK 295
K F+IK I D + + R K + C+ H + +P + + ++
Sbjct: 253 KKFVIK---PIDKKAPDFVFYAPRLR-INKRILQLCMGNHELYMRRRKPDTIEVQQMKAQ 308
Query: 296 GSSFRYSGRTQRQLLEYGRKGR 317
++ + +RQ LE +K R
Sbjct: 309 AREEKHQKQLERQQLETEKKRR 330
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 111 bits (277), Expect = 3e-24
Identities = 78/284 (27%), Positives = 141/284 (49%), Gaps = 22/284 (7%)
Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
D++ F + K GK LF+L C L L E +FGL++ + WL++ K + V
Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY-TIKDTVAWLKMDKKVLDHDVSK 88
Query: 70 PKEIVFKFMVKFFPVDPGH-LREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
+ + F F+ KF+P + L +E+T++LF LQ+KK + ++ C + L+ S+ +Q+
Sbjct: 89 EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148
Query: 129 ELGDFHEETDRK-HLAQTRYLPNQ---------DCLEGKIMHFHQKHIGRSPAESDILLL 178
+ GD+ ++ LAQ LP + + E +I ++ +H GR+ E+++ L
Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208
Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN---TFNWAKIRKLSFKR 235
IA+ L+MYG+ + +G ++ L V +G+ + ++ +F W +IR +S+
Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268
Query: 236 KHFLIK-LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFF 278
K F IK L I D +F + K + C+ H F
Sbjct: 269 KEFTIKPLDKKI-----DVFKFNSSKLRVNKLILQLCIGNHDLF 307
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 111 bits (277), Expect = 3e-24
Identities = 78/284 (27%), Positives = 141/284 (49%), Gaps = 22/284 (7%)
Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
D++ F + K GK LF+L C L L E +FGL++ + WL++ K + V
Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY-TIKDTVAWLKMDKKVLDHDVSK 88
Query: 70 PKEIVFKFMVKFFPVDPGH-LREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
+ + F F+ KF+P + L +E+T++LF LQ+KK + ++ C + L+ S+ +Q+
Sbjct: 89 EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148
Query: 129 ELGDFHEETDRK-HLAQTRYLPNQ---------DCLEGKIMHFHQKHIGRSPAESDILLL 178
+ GD+ ++ LAQ LP + + E +I ++ +H GR+ E+++ L
Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208
Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN---TFNWAKIRKLSFKR 235
IA+ L+MYG+ + +G ++ L V +G+ + ++ +F W +IR +S+
Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268
Query: 236 KHFLIK-LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFF 278
K F IK L I D +F + K + C+ H F
Sbjct: 269 KEFTIKPLDKKI-----DVFKFNSSKLRVNKLILQLCIGNHDLF 307
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 111 bits (277), Expect = 3e-24
Identities = 78/284 (27%), Positives = 141/284 (49%), Gaps = 22/284 (7%)
Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
D++ F + K GK LF+L C L L E +FGL++ + WL++ K + V
Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY-TIKDTVAWLKMDKKVLDHDVSK 88
Query: 70 PKEIVFKFMVKFFPVDPGH-LREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
+ + F F+ KF+P + L +E+T++LF LQ+KK + ++ C + L+ S+ +Q+
Sbjct: 89 EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148
Query: 129 ELGDFHEETDRK-HLAQTRYLPNQ---------DCLEGKIMHFHQKHIGRSPAESDILLL 178
+ GD+ ++ LAQ LP + + E +I ++ +H GR+ E+++ L
Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208
Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN---TFNWAKIRKLSFKR 235
IA+ L+MYG+ + +G ++ L V +G+ + ++ +F W +IR +S+
Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268
Query: 236 KHFLIK-LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFF 278
K F IK L I D +F + K + C+ H F
Sbjct: 269 KEFTIKPLDKKI-----DVFKFNSSKLRVNKLILQLCIGNHDLF 307
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 111 bits (277), Expect = 3e-24
Identities = 78/284 (27%), Positives = 141/284 (49%), Gaps = 22/284 (7%)
Query: 11 DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
D++ F + K GK LF+L C L L E +FGL++ + WL++ K + V
Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY-TIKDTVAWLKMDKKVLDHDVSK 88
Query: 70 PKEIVFKFMVKFFPVDPGH-LREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
+ + F F+ KF+P + L +E+T++LF LQ+KK + ++ C + L+ S+ +Q+
Sbjct: 89 EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148
Query: 129 ELGDFHEETDRK-HLAQTRYLPNQ---------DCLEGKIMHFHQKHIGRSPAESDILLL 178
+ GD+ ++ LAQ LP + + E +I ++ +H GR+ E+++ L
Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208
Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN---TFNWAKIRKLSFKR 235
IA+ L+MYG+ + +G ++ L V +G+ + ++ +F W +IR +S+
Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268
Query: 236 KHFLIK-LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFF 278
K F IK L I D +F + K + C+ H F
Sbjct: 269 KEFTIKPLDKKI-----DVFKFNSSKLRVNKLILQLCIGNHDLF 307
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,690,277
Number of Sequences: 37866
Number of extensions: 1366876
Number of successful extensions: 3662
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 3478
Number of HSP's gapped (non-prelim): 79
length of query: 714
length of database: 18,247,518
effective HSP length: 109
effective length of query: 605
effective length of database: 14,120,124
effective search space: 8542675020
effective search space used: 8542675020
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.