Guide to the Human Genome
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Search of human proteins with 34916000

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|34916000 FERM domain containing 7 [Homo sapiens]
         (714 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|34916000 FERM domain containing 7 [Homo sapiens]                  1452   0.0  
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform...   431   e-120
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...   388   e-108
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s...   243   4e-64
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform...   240   3e-63
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform...   239   5e-63
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho...   236   5e-62
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor...   236   7e-62
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor...   236   7e-62
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ...   236   7e-62
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi...   234   2e-61
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis...   234   2e-61
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]         208   1e-53
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi...   197   4e-50
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo...   193   5e-49
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo...   192   7e-49
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s...   189   8e-48
gi|117500790 FERM domain containing 3 [Homo sapiens]                  182   7e-46
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i...   174   3e-43
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i...   174   3e-43
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]        172   1e-42
gi|4506467 radixin [Homo sapiens]                                     125   2e-28
gi|4505257 moesin [Homo sapiens]                                      124   4e-28
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ...   122   9e-28
gi|161702986 ezrin [Homo sapiens]                                     117   5e-26
gi|21614499 ezrin [Homo sapiens]                                      117   5e-26
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]                  111   3e-24
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]                  111   3e-24
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]                  111   3e-24
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]                   111   3e-24

>gi|34916000 FERM domain containing 7 [Homo sapiens]
          Length = 714

 Score = 1452 bits (3758), Expect = 0.0
 Identities = 714/714 (100%), Positives = 714/714 (100%)

Query: 1   MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELL 60
           MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELL
Sbjct: 1   MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELL 60

Query: 61  KPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTAL 120
           KPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTAL
Sbjct: 61  KPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTAL 120

Query: 121 MVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDI 180
           MVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDI
Sbjct: 121 MVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDI 180

Query: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240
           ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI
Sbjct: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240

Query: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300
           KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR
Sbjct: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300

Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGG 360
           YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGG
Sbjct: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGG 360

Query: 361 GYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYMD 420
           GYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYMD
Sbjct: 361 GYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYMD 420

Query: 421 PVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVPY 480
           PVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVPY
Sbjct: 421 PVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVPY 480

Query: 481 IPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVEPTAMKPAERSPRNIRM 540
           IPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVEPTAMKPAERSPRNIRM
Sbjct: 481 IPCTGQQVGIMPPQVFFYVDKPPQVPRWSPIRAEERTSPHSYVEPTAMKPAERSPRNIRM 540

Query: 541 KSFQQDLQVLQEAIARTSGRSNINVGLEEEDPNLEDAFVCNIQEQTPKRSQSQSDMKTIR 600
           KSFQQDLQVLQEAIARTSGRSNINVGLEEEDPNLEDAFVCNIQEQTPKRSQSQSDMKTIR
Sbjct: 541 KSFQQDLQVLQEAIARTSGRSNINVGLEEEDPNLEDAFVCNIQEQTPKRSQSQSDMKTIR 600

Query: 601 FPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILKP 660
           FPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILKP
Sbjct: 601 FPFGSEFRPLGPCPALSHKADLFTDMFAEQELPAVLMDQSTAERYVASESSDSESEILKP 660

Query: 661 DYYALYGKEIRSPMARIRLSSGSLQLDEEDEDAYFNTPTAEDRTSLKPCNYFLA 714
           DYYALYGKEIRSPMARIRLSSGSLQLDEEDEDAYFNTPTAEDRTSLKPCNYFLA
Sbjct: 661 DYYALYGKEIRSPMARIRLSSGSLQLDEEDEDAYFNTPTAEDRTSLKPCNYFLA 714


>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
           [Homo sapiens]
          Length = 1045

 Score =  431 bits (1107), Expect = e-120
 Identities = 231/443 (52%), Positives = 299/443 (67%), Gaps = 22/443 (4%)

Query: 1   MLHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELL 60
           ++ +K+Q LDD+Q+ F V Q++ GK L +  C+HLNL E +YFGLEF  H    VWL+LL
Sbjct: 39  LVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLL 98

Query: 61  KPITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTAL 120
           KPI KQ++ PK +V KF+VKFFP D   L+EELTRYLF LQ+K+DLA GRL C+D   AL
Sbjct: 99  KPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAAL 158

Query: 121 MVSHILQSELGDFHEETDRKHLAQTRYLPNQDCLEGKIMHFHQKHIGRSPAESDILLLDI 180
           ++SHI+QSE+GDF E  DR+HLA+ +Y+P QD LE KI+ FH  HIG++PAESD  LL+I
Sbjct: 159 LISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEI 218

Query: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240
           AR+L+MYGIR HPA D EG +I+LAVA+ G+LV +G TKIN FNWAK+RKLSFKRK FLI
Sbjct: 219 ARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLI 278

Query: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300
           KL  +     +DTLEF MASRD CK+FWK CVE+HAFFRL EEPK KPK +L S+GSSFR
Sbjct: 279 KLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFR 338

Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHE-RQCRSSP-DLLSDVSKQ-VEDLRLA 357
           +SGRTQ+Q+L+Y ++G  K + FERKH  S+ H  R   S P +L S+V +Q  +   L 
Sbjct: 339 FSGRTQKQVLDYVKEGGHKKVQFERKH--SKIHSIRSLASQPTELNSEVLEQSQQSTSLT 396

Query: 358 YGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSK--PEADPTLLHQSQSSSSFP 415
           +G G         A  P  +S RR    +V+      H    P   P    Q+  ++S P
Sbjct: 397 FGEG---------AESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNKQADGAASAP 447

Query: 416 F-----IYMDPVFNTEPNPNPDP 433
                 +  D    ++P P P P
Sbjct: 448 TEEEEEVVKDRTQQSKPQP-PQP 469


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
           sapiens]
          Length = 1054

 Score =  388 bits (997), Expect = e-108
 Identities = 187/327 (57%), Positives = 241/327 (73%), Gaps = 2/327 (0%)

Query: 2   LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
           LHL+V+ LD++ +IF ++ K  G+ L       LNL E +YFG+EF +     +WLE +K
Sbjct: 44  LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMK 103

Query: 62  PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
           PI +Q++ PK +V +  VKFFP DPG L+EE TRYLF LQ+K+DL   RL C+D   AL+
Sbjct: 104 PIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALL 163

Query: 122 VSHILQSELGDFHEETDRKHLAQTRYLPNQD-CLEGKIMHFHQKHIGRSPAESDILLLDI 180
            SH+LQSE+GD+ E  DR+HL    YLP Q  CLE KI+ FHQKH+G++PAESD  +L+I
Sbjct: 164 TSHLLQSEIGDYDETLDREHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAESDFQVLEI 222

Query: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240
           ARKL+MYGIR H ASD EG +I LAV+HMGVLV +G TKINTFNW+K+RKLSFKRK FLI
Sbjct: 223 ARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLI 282

Query: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300
           KLH  +    +DTLEF + SRD CK FWK CVEYH FFRL ++PK K K +  S+GSSFR
Sbjct: 283 KLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFR 342

Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKH 327
           YSGRTQ+QL++Y +   +K +P+ER+H
Sbjct: 343 YSGRTQKQLVDYFKDSGMKRIPYERRH 369


>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
           sapiens]
          Length = 1087

 Score =  243 bits (620), Expect = 4e-64
 Identities = 163/488 (33%), Positives = 244/488 (50%), Gaps = 30/488 (6%)

Query: 2   LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
           +  KV  LD S+    V+++S G+ LF+  C HLNL EK+YFGL +        WL+  K
Sbjct: 110 MQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAK 169

Query: 62  PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
            I KQV++     F F VKF+P DP  L E++TRY   LQ++ D+  GRLPCS    AL+
Sbjct: 170 EIKKQVRSGAWH-FSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALL 228

Query: 122 VSHILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLD 179
            S+ +QSELGD+  +E    ++++ R+ PN    LE K++  H+ H G +PAE+++  L+
Sbjct: 229 GSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLE 288

Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239
            A+KL MYG+  H A D EG++I L V   G+L+ R   +IN F W K+ K+S+KR +F 
Sbjct: 289 NAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFY 348

Query: 240 IKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSF 299
           IK+        + T+ F + +  A K  WK CVE+H FFRL   P++ PK  L + GS F
Sbjct: 349 IKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLL-LPEAPPKKFL-TLGSKF 406

Query: 300 RYSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYG 359
           RYSGRTQ Q        R  S   +R   P+ Y ER       +   +  +V       G
Sbjct: 407 RYSGRTQAQT-------RRASALIDR---PAPYFERSSSKRYTMSRSLDGEV-------G 449

Query: 360 GGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYM 419
            G Y    G+  +  +        A E     E +  K E + T +   +     P +  
Sbjct: 450 TGQYATTKGISQTNLITTVTPEKKAEEERDEEEDKRRKGE-EVTPISAIRHEGKSPGLGT 508

Query: 420 DPVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVP 479
           D    + P+ +  P       +S +  +  CK +   +  Y    ++  P +    +D P
Sbjct: 509 DSCPLSPPSTHCAP-------TSPTELRRRCKENDCKLPGYEPSRAEHLPGEPALDSDGP 561

Query: 480 YIPCTGQQ 487
             P  G Q
Sbjct: 562 GRPYLGDQ 569


>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
           [Homo sapiens]
          Length = 881

 Score =  240 bits (613), Expect = 3e-63
 Identities = 149/409 (36%), Positives = 217/409 (53%), Gaps = 17/409 (4%)

Query: 5   KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
           +V  LD S+    V++   G+ LF+L C HLNL EK+YFGL FC       WL+  K I 
Sbjct: 100 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 159

Query: 65  KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
           KQ+++     F F VKF+P DP  L E++TRY   LQ++ D+  GRLPCS    AL+ S+
Sbjct: 160 KQIRS-SPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 218

Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182
            +Q+ELGD+  EE    ++++ R+ PNQ   LE +IM  H+ + G +P E++I  L+ A+
Sbjct: 219 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 278

Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
           KL MYG+  H A D EG+ I L V   G+L+ R   +IN F W KI K+S+KR +F IK+
Sbjct: 279 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 338

Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302
                   + T+ F + +  + K  WK C+E+H FFRL   P+  PK  L   GS FRYS
Sbjct: 339 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL-VSPEPPPKGFLV-MGSKFRYS 396

Query: 303 GRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGGGY 362
           GRTQ Q        R  S   +R   P+ + ER       +   +         +    +
Sbjct: 397 GRTQAQT-------RQASALIDR---PAPFFERSSSKRYTMSRSLDGAEFSRPASVSENH 446

Query: 363 YQNVNGVHASEPVLESRRRNSAL--EVTFATELEHSKPEADPTLLHQSQ 409
               +G    E      +R+ A   EV   T+++  KPE + T  H+ +
Sbjct: 447 DAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQE 495


>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
           [Homo sapiens]
          Length = 779

 Score =  239 bits (611), Expect = 5e-63
 Identities = 131/306 (42%), Positives = 183/306 (59%), Gaps = 5/306 (1%)

Query: 5   KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
           +V  LD S+    V++   G+ LF+L C HLNL EK+YFGL FC       WL+  K I 
Sbjct: 38  RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 97

Query: 65  KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
           KQ+++     F F VKF+P DP  L E++TRY   LQ++ D+  GRLPCS    AL+ S+
Sbjct: 98  KQIRS-SPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 156

Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182
            +Q+ELGD+  EE    ++++ R+ PNQ   LE +IM  H+ + G +P E++I  L+ A+
Sbjct: 157 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 216

Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
           KL MYG+  H A D EG+ I L V   G+L+ R   +IN F W KI K+S+KR +F IK+
Sbjct: 217 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 276

Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302
                   + T+ F + +  + K  WK C+E+H FFRL   P+  PK  L   GS FRYS
Sbjct: 277 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL-VSPEPPPKGFLV-MGSKFRYS 334

Query: 303 GRTQRQ 308
           GRTQ Q
Sbjct: 335 GRTQAQ 340


>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
           sapiens]
          Length = 926

 Score =  236 bits (602), Expect = 5e-62
 Identities = 131/326 (40%), Positives = 188/326 (57%), Gaps = 7/326 (2%)

Query: 6   VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNV-WLELLKPIT 64
           +  LD++ + F V++   G+ L ++   HL+L E++YFGL+    S +N  WL+  KPI 
Sbjct: 33  ILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIR 92

Query: 65  KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
           KQ+K        F VKFF  DP  L+EE TRY + LQIK+D+  GRLPC  N  AL+ S 
Sbjct: 93  KQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASF 152

Query: 125 ILQSELGDFHEETDRK-HLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLDIAR 182
            +QSELGD+ +  +   +L+   ++PNQ    E +I   HQ+HIG SPAE++   L+ AR
Sbjct: 153 AVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNTAR 212

Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
            L++YG+  H A D    +I + V   G+L+ +   ++NTF W KI K+SFK K F I+L
Sbjct: 213 TLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFIQL 272

Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLC---SKGSSF 299
              +    +  L F M +  ACK  WK CVE+H FFRL + P    K       + GS F
Sbjct: 273 RKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRL-DRPLPPQKNFFAHYFTLGSKF 331

Query: 300 RYSGRTQRQLLEYGRKGRLKSLPFER 325
           RY GRT+ Q ++YG++   K   F R
Sbjct: 332 RYCGRTEVQSVQYGKEKANKDRVFAR 357


>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score =  236 bits (601), Expect = 7e-62
 Identities = 129/306 (42%), Positives = 183/306 (59%), Gaps = 4/306 (1%)

Query: 5   KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
           KV  LD ++    +++ + G+ LF+  C HLNL EK+YFGL F        WL+  K I 
Sbjct: 221 KVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIK 280

Query: 65  KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
           +Q++N   + F F VKF+P DP  L E++TRY   LQ+++D+A GRLPCS    AL+ S+
Sbjct: 281 RQLRNLPWL-FTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSY 339

Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182
            LQ+ELGD+  EE     L++ ++ P Q   LE K+   H+ H G SPA++D   L+ A+
Sbjct: 340 TLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAK 399

Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
           +L MYG+  H A D EG+ I L V   G+L+ +   +IN F W KI K+S+KR +F IK+
Sbjct: 400 RLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKV 459

Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302
               L   + T+ F + +  A K  WK CVE+H F+RL   P+  PK    + GS FRYS
Sbjct: 460 RPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL-VSPEQPPKAKFLTLGSKFRYS 518

Query: 303 GRTQRQ 308
           GRTQ Q
Sbjct: 519 GRTQAQ 524


>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score =  236 bits (601), Expect = 7e-62
 Identities = 129/306 (42%), Positives = 183/306 (59%), Gaps = 4/306 (1%)

Query: 5   KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
           KV  LD ++    +++ + G+ LF+  C HLNL EK+YFGL F        WL+  K I 
Sbjct: 221 KVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIK 280

Query: 65  KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
           +Q++N   + F F VKF+P DP  L E++TRY   LQ+++D+A GRLPCS    AL+ S+
Sbjct: 281 RQLRNLPWL-FTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSY 339

Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182
            LQ+ELGD+  EE     L++ ++ P Q   LE K+   H+ H G SPA++D   L+ A+
Sbjct: 340 TLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAK 399

Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
           +L MYG+  H A D EG+ I L V   G+L+ +   +IN F W KI K+S+KR +F IK+
Sbjct: 400 RLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKV 459

Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302
               L   + T+ F + +  A K  WK CVE+H F+RL   P+  PK    + GS FRYS
Sbjct: 460 RPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL-VSPEQPPKAKFLTLGSKFRYS 518

Query: 303 GRTQRQ 308
           GRTQ Q
Sbjct: 519 GRTQAQ 524


>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
           [Homo sapiens]
          Length = 1005

 Score =  236 bits (601), Expect = 7e-62
 Identities = 129/306 (42%), Positives = 183/306 (59%), Gaps = 4/306 (1%)

Query: 5   KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
           KV  LD ++    +++ + G+ LF+  C HLNL EK+YFGL F        WL+  K I 
Sbjct: 221 KVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIK 280

Query: 65  KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
           +Q++N   + F F VKF+P DP  L E++TRY   LQ+++D+A GRLPCS    AL+ S+
Sbjct: 281 RQLRNLPWL-FTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSY 339

Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182
            LQ+ELGD+  EE     L++ ++ P Q   LE K+   H+ H G SPA++D   L+ A+
Sbjct: 340 TLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAK 399

Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
           +L MYG+  H A D EG+ I L V   G+L+ +   +IN F W KI K+S+KR +F IK+
Sbjct: 400 RLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKV 459

Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302
               L   + T+ F + +  A K  WK CVE+H F+RL   P+  PK    + GS FRYS
Sbjct: 460 RPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL-VSPEQPPKAKFLTLGSKFRYS 518

Query: 303 GRTQRQ 308
           GRTQ Q
Sbjct: 519 GRTQAQ 524


>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 2 [Homo sapiens]
          Length = 641

 Score =  234 bits (597), Expect = 2e-61
 Identities = 128/309 (41%), Positives = 182/309 (58%), Gaps = 4/309 (1%)

Query: 2   LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
           +H KV  LDD+    VV++ + G+ L    C HLNL E++YFGL    ++ +  WL+  K
Sbjct: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60

Query: 62  PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
            I KQV+      F F VKF+P DP  L E++TRY   LQ+++D+  GRLPCS    AL+
Sbjct: 61  EIKKQVRGVPWN-FTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119

Query: 122 VSHILQSELGDFHEETDR-KHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLD 179
            S+ +QSELGD+  E     +++  +  PNQ   LE K+M  H+ +   +PA++D+  L+
Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179

Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239
            A+KL MYG+  H A D EG+ I L V   G+LV +   +IN F W K+ K+S+KR  F 
Sbjct: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239

Query: 240 IKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSF 299
           IK+        + T+ F + S  A K  WK CVE+H FFRL+    + PK+   + GS F
Sbjct: 240 IKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLT-STDTIPKSKFLALGSKF 298

Query: 300 RYSGRTQRQ 308
           RYSGRTQ Q
Sbjct: 299 RYSGRTQAQ 307


>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
           RH-linked) isoform 3 [Homo sapiens]
          Length = 588

 Score =  234 bits (597), Expect = 2e-61
 Identities = 128/309 (41%), Positives = 182/309 (58%), Gaps = 4/309 (1%)

Query: 2   LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
           +H KV  LDD+    VV++ + G+ L    C HLNL E++YFGL    ++ +  WL+  K
Sbjct: 1   MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60

Query: 62  PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
            I KQV+      F F VKF+P DP  L E++TRY   LQ+++D+  GRLPCS    AL+
Sbjct: 61  EIKKQVRGVPWN-FTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 119

Query: 122 VSHILQSELGDFHEETDR-KHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLD 179
            S+ +QSELGD+  E     +++  +  PNQ   LE K+M  H+ +   +PA++D+  L+
Sbjct: 120 GSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLE 179

Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239
            A+KL MYG+  H A D EG+ I L V   G+LV +   +IN F W K+ K+S+KR  F 
Sbjct: 180 NAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF 239

Query: 240 IKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSF 299
           IK+        + T+ F + S  A K  WK CVE+H FFRL+    + PK+   + GS F
Sbjct: 240 IKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLT-STDTIPKSKFLALGSKF 298

Query: 300 RYSGRTQRQ 308
           RYSGRTQ Q
Sbjct: 299 RYSGRTQAQ 307


>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
          Length = 570

 Score =  208 bits (530), Expect = 1e-53
 Identities = 123/339 (36%), Positives = 189/339 (55%), Gaps = 10/339 (2%)

Query: 6   VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITK 65
           V+ LDDS+    + + + G+ LF+L C HLNL EK+YFG+ F        WLE  K + K
Sbjct: 21  VRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVK 80

Query: 66  QVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHI 125
           Q+++       F VKF+P DP  L+EE+TRYL  LQIK+DL  GRL C  +  AL+ ++I
Sbjct: 81  QLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYI 140

Query: 126 LQSELGDFHE-ETDRKHLAQTRYLP-NQDCLEGKIMHFHQKHI-GRSPAESDILLLDIAR 182
           LQ+E+GD+   +    + ++ ++ P + + LE KI   H+  + G++PA S++  L  A+
Sbjct: 141 LQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQ 200

Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
            L+ YG+ PHP  D  G    LA    G +VL+GN +++   W ++ KL F+ K F   L
Sbjct: 201 TLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFY--L 258

Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRL--SEEPKSKPKTLLCSKGSSFR 300
           + +     K  L +   + +ACK  WK  +E  AF++L  S + ++   + L  KGS FR
Sbjct: 259 YVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFR 318

Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRS 339
           YSGR  ++++E   K  +K  P E  H       R C S
Sbjct: 319 YSGRVAKEVMESSAK--IKREPPE-IHRAGMVPSRSCPS 354


>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 1 [Homo sapiens]
          Length = 775

 Score =  197 bits (500), Expect = 4e-50
 Identities = 119/308 (38%), Positives = 168/308 (54%), Gaps = 10/308 (3%)

Query: 9   LDDSQKIFVVDQKSSGKALFNLSCS------HLNLAEKEYFGLEFCSHSGNNVWLELLKP 62
           L++  KI V ++    KA   L  S      H N+  K     +         WL+  K 
Sbjct: 176 LEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVETWLDSAKE 235

Query: 63  ITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMV 122
           I KQV+      F F VKF+P DP  L E++TRY   LQ+++D+  GRLPCS    AL+ 
Sbjct: 236 IKKQVRGVPWN-FTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 294

Query: 123 SHILQSELGDFHEETDR-KHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDI 180
           S+ +QSELGD+  E     +++  +  PNQ   LE K+M  H+ +   +PA++D+  L+ 
Sbjct: 295 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 354

Query: 181 ARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLI 240
           A+KL MYG+  H A D EG+ I L V   G+LV +   +IN F W K+ K+S+KR  F I
Sbjct: 355 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 414

Query: 241 KLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFR 300
           K+        + T+ F + S  A K  WK CVE+H FFRL+    + PK+   + GS FR
Sbjct: 415 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLT-STDTIPKSKFLALGSKFR 473

Query: 301 YSGRTQRQ 308
           YSGRTQ Q
Sbjct: 474 YSGRTQAQ 481


>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
           1 [Homo sapiens]
          Length = 518

 Score =  193 bits (490), Expect = 5e-49
 Identities = 132/414 (31%), Positives = 206/414 (49%), Gaps = 29/414 (7%)

Query: 2   LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
           L+ +V  LD ++    + + + G+ LF+    HL+L E +YFGL+F   +    WL+  K
Sbjct: 85  LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144

Query: 62  PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
           PI KQ+K        F VK++  +P +LREE TRYLF LQ++ D+  G+L C       +
Sbjct: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204

Query: 122 VSHILQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLD 179
            +  LQ+ELG+    E   + +++ R++PNQ + +E  I    ++  G+SPA++++  L+
Sbjct: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264

Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239
            A+ L+MYG+  H     +G +  L +   G+L+  G  KI  F W KI K+ FK+    
Sbjct: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL- 323

Query: 240 IKLHANILVLCKD---------TLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKP-K 289
                  LV+ +D         T  F + S   CK  WK  VE+HAFFRL     SK  +
Sbjct: 324 ------TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNR 377

Query: 290 TLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFER---KHYPSQYHERQCRSSPDLLSD 346
           +     GS FR+SGRT+ Q     R  R  +  FER   K YPS+ H     S+P + + 
Sbjct: 378 SDFIRLGSRFRFSGRTEYQATHGSRLRRTST--FERKPSKRYPSRRHSTFKASNPVIAAQ 435

Query: 347 VSKQVEDLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEA 400
           +  +       Y   Y+ N   +H S+P       N  +  +F  +  H K  A
Sbjct: 436 LCSKTNPEVHNYQPQYHPN---IHPSQPRWHPHSPN--VRPSFQDDRSHWKASA 484


>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
           2 [Homo sapiens]
          Length = 900

 Score =  192 bits (489), Expect = 7e-49
 Identities = 127/388 (32%), Positives = 198/388 (51%), Gaps = 27/388 (6%)

Query: 2   LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
           L+ +V  LD ++    + + + G+ LF+    HL+L E +YFGL+F   +    WL+  K
Sbjct: 85  LYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAK 144

Query: 62  PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
           PI KQ+K        F VK++  +P +LREE TRYLF LQ++ D+  G+L C       +
Sbjct: 145 PIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVEL 204

Query: 122 VSHILQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLD 179
            +  LQ+ELG+    E   + +++ R++PNQ + +E  I    ++  G+SPA++++  L+
Sbjct: 205 AALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLN 264

Query: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239
            A+ L+MYG+  H     +G +  L +   G+L+  G  KI  F W KI K+ FK+    
Sbjct: 265 KAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL- 323

Query: 240 IKLHANILVLCKD---------TLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKP-K 289
                  LV+ +D         T  F + S   CK  WK  VE+HAFFRL     SK  +
Sbjct: 324 ------TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNR 377

Query: 290 TLLCSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFER---KHYPSQYHERQCRSSPDLLSD 346
           +     GS FR+SGRT+ Q     R  R  +  FER   K YPS+ H     S+P + + 
Sbjct: 378 SDFIRLGSRFRFSGRTEYQATHGSRLRRTST--FERKPSKRYPSRRHSTFKASNPVIAAQ 435

Query: 347 VSKQVEDLRLAYGGGYYQNVNGVHASEP 374
           +  +       Y   Y+ N   +H S+P
Sbjct: 436 LCSKTNPEVHNYQPQYHPN---IHPSQP 460


>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
           sapiens]
          Length = 733

 Score =  189 bits (480), Expect = 8e-48
 Identities = 130/376 (34%), Positives = 198/376 (52%), Gaps = 32/376 (8%)

Query: 5   KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
           +V  LD +     + +K+ G+ LF+    HL+L E +YFGL F   +    WL+  K I 
Sbjct: 46  RVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSIK 105

Query: 65  KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
           KQVK          VKF+  +P +LREELTRYLF LQ+K+D+  G+L C  +    + ++
Sbjct: 106 KQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQLAAY 165

Query: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAESDILLLDIAR 182
            LQ+ELGD+   E   + +++ R++P Q + +E  I    +++ G++PA+++   L+ A+
Sbjct: 166 NLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLNKAK 225

Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
            L+MYG+  H     +G    L +   GVLV  G+TKI  F W KI +L FK+       
Sbjct: 226 WLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKL---- 281

Query: 243 HANILVLCKD---------TLEFTMASRDACKAFWKTCVEYHAFFRL-SEEPKSKPKTLL 292
               LV+ +D         T  F +    ACK  WK  VE+HAFFRL     KS  ++  
Sbjct: 282 ---TLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSHRSGF 338

Query: 293 CSKGSSFRYSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQ------CRSSPDLLS- 345
              GS FRYSG+T+ Q  +  +  R  S  FER+  PS+ + R+      C + P+ LS 
Sbjct: 339 IRLGSRFRYSGKTEYQTTKTNKARR--STSFERR--PSKRYSRRTLQMKACATKPEELSV 394

Query: 346 --DVSKQVEDLRLAYG 359
             +VS Q    + A+G
Sbjct: 395 HNNVSTQSNGSQQAWG 410


>gi|117500790 FERM domain containing 3 [Homo sapiens]
          Length = 597

 Score =  182 bits (463), Expect = 7e-46
 Identities = 139/459 (30%), Positives = 219/459 (47%), Gaps = 27/459 (5%)

Query: 6   VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITK 65
           ++ LDDS+    + +++ G+ L +  C++ +L EK+YFG+ +        WLE  K I K
Sbjct: 36  IRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFK 95

Query: 66  QVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHI 125
           Q+K        F VKF+P +P  ++EELTRYL  LQIK+D+  GRL CS +  A + + I
Sbjct: 96  QMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACI 155

Query: 126 LQSELGDFH-EETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHI-GRSPAESDILLLDIAR 182
           +Q+ELGD+  +E    ++++    P Q   LE KI+  H+  + G+SP  ++  LL  A 
Sbjct: 156 VQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAH 215

Query: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
            L+ YG+ PHP  D  G    L     G +V +GN +I+   W  + KL F+ K F +  
Sbjct: 216 TLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYV-- 273

Query: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRL--SEEPKSKPKTLLCSKGSSFR 300
                   K  L F  ++  ACK  WK  VE  AF++   S + K+   + +  KGS FR
Sbjct: 274 -IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSRFR 332

Query: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSS--------PDLLSDVSKQVE 352
           YSG+  ++++E   K + +     R +                       LL   S+Q E
Sbjct: 333 YSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPSPSEQEE 392

Query: 353 DLRLAYGGGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQ---SQ 409
           +L L  G    +  N    S P++ S    +A E       E  K + +P  + +   + 
Sbjct: 393 ELPLGEGVPLPKEEN---ISAPLISSSPVKAAREYEDPPSEEEDKIKEEPLTISELVYNP 449

Query: 410 SSSSFPFIYMDPVFNTEPNPNPD-PRDIFSERSSLSSFQ 447
           S+S  P     PV + E +   D P  +  ER    SF+
Sbjct: 450 SASLLP----TPVDDDEIDMLFDCPSRLELEREDTDSFE 484


>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
           isoform 2 [Homo sapiens]
          Length = 868

 Score =  174 bits (440), Expect = 3e-43
 Identities = 96/278 (34%), Positives = 152/278 (54%), Gaps = 5/278 (1%)

Query: 6   VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNV-WLELLKPIT 64
           + FLD   + F V ++ +G+ L ++  +HL + EKEYFGL+    S ++  WLE  K I 
Sbjct: 33  IHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIR 92

Query: 65  KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
           KQ+K        F V+FF  DP  L++E TR+L+ LQ+K D+  GRL C  N   ++ S+
Sbjct: 93  KQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASY 152

Query: 125 ILQSELGDFHEETDRK-HLAQTRYLP--NQDCLEGKIMHFHQKHIGRSPAESDILLLDIA 181
            +QS  GD++       +L+ + ++P  N+D L  K+   H++H G   +E++   ++IA
Sbjct: 153 AVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLT-KVESLHEQHSGLKQSEAESCYINIA 211

Query: 182 RKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIK 241
           R LD YG+  H   D   + + + +A  GV V R     + + W  I K+SFKRK F I 
Sbjct: 212 RTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIH 271

Query: 242 LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFR 279
                    +  + F M +  +CK  WK+CVE+H FF+
Sbjct: 272 QRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQ 309


>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
           isoform 1 [Homo sapiens]
          Length = 913

 Score =  174 bits (440), Expect = 3e-43
 Identities = 96/278 (34%), Positives = 152/278 (54%), Gaps = 5/278 (1%)

Query: 6   VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNV-WLELLKPIT 64
           + FLD   + F V ++ +G+ L ++  +HL + EKEYFGL+    S ++  WLE  K I 
Sbjct: 33  IHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIR 92

Query: 65  KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
           KQ+K        F V+FF  DP  L++E TR+L+ LQ+K D+  GRL C  N   ++ S+
Sbjct: 93  KQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASY 152

Query: 125 ILQSELGDFHEETDRK-HLAQTRYLP--NQDCLEGKIMHFHQKHIGRSPAESDILLLDIA 181
            +QS  GD++       +L+ + ++P  N+D L  K+   H++H G   +E++   ++IA
Sbjct: 153 AVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLT-KVESLHEQHSGLKQSEAESCYINIA 211

Query: 182 RKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIK 241
           R LD YG+  H   D   + + + +A  GV V R     + + W  I K+SFKRK F I 
Sbjct: 212 RTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIH 271

Query: 242 LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFR 279
                    +  + F M +  +CK  WK+CVE+H FF+
Sbjct: 272 QRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQ 309


>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
          Length = 686

 Score =  172 bits (436), Expect = 1e-42
 Identities = 105/324 (32%), Positives = 168/324 (51%), Gaps = 23/324 (7%)

Query: 3   HLKVQFLDDSQKIFVVDQK-----SSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWL 57
           + +V  LD+S+      Q+     + G  + +    H+NL E +YFGL +C  S    WL
Sbjct: 12  YCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWL 71

Query: 58  ELLKPITKQ---VKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCS 114
           +  K + +    +         F +KF+  DP  L+EE+TRY F LQ+K+D+  GRLPC 
Sbjct: 72  DPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCP 131

Query: 115 DNCTALMVSHILQSELGDFHE-ETDRKHLAQTRYLPNQ-DCLEGKIMHFHQKHIGRSPAE 172
            N  A + ++ +QSELGD+   +    ++++ R++P+Q + LE  I   H+  +G+ P+E
Sbjct: 132 VNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSE 191

Query: 173 SDILLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLS 232
           +++  L  A+ L+MYG+  HP       +  L +  +GV+V +   ++  + W +I K+ 
Sbjct: 192 AELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVH 251

Query: 233 FKRKHFLIKLHANILVLCKDTLE----FTMASRDACKAFWKTCVEYHAFFRLSEEPKSKP 288
           FK   F ++      VL KD  E    F   S+ ACK  WK  VE+H FFR+ E   +  
Sbjct: 252 FKETQFELR------VLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSL 305

Query: 289 KTLLCSKGS---SFRYSGRTQRQL 309
              L   GS     RYSGRT  Q+
Sbjct: 306 SRKLSKFGSIRYKHRYSGRTALQM 329


>gi|4506467 radixin [Homo sapiens]
          Length = 583

 Score =  125 bits (313), Expect = 2e-28
 Identities = 83/283 (29%), Positives = 142/283 (50%), Gaps = 32/283 (11%)

Query: 11  DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
           D++  F +   ++GK LF+     + L E  +FGL++    G + WL+L K +T+Q VK 
Sbjct: 13  DAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKK 72

Query: 70  PKEIVFKFMVKFFPVDPG-HLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
              + FKF  KFFP D    L +E+T+ LF LQ+K+ +    + C      L+ S+ +Q+
Sbjct: 73  ENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQA 132

Query: 129 ELGDFHEETDRK-HLAQTRYLP---------NQDCLEGKIMHFHQKHIGRSPAESDILLL 178
           + GD+++E  +  +LA  R LP          ++  E +I ++H++H G    +S +  L
Sbjct: 133 KYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYL 192

Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINT---FNWAKIRKLSFKR 235
            IA+ L+MYG+      + +G ++ L V  +G+ +   + K+     F W++IR +SF  
Sbjct: 193 KIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFND 252

Query: 236 KHFLIK-----------------LHANILVLCKDTLEFTMASR 261
           K F+IK                 ++  IL LC    E  M  R
Sbjct: 253 KKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRR 295


>gi|4505257 moesin [Homo sapiens]
          Length = 577

 Score =  124 bits (310), Expect = 4e-28
 Identities = 82/283 (28%), Positives = 142/283 (50%), Gaps = 32/283 (11%)

Query: 11  DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
           D++  F +   ++GK LF+     + L E  +FGL++    G + WL+L K +T Q V+ 
Sbjct: 13  DAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRK 72

Query: 70  PKEIVFKFMVKFFPVDPG-HLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
              ++FKF  KF+P D    L +++T+ LF LQ+K+ +    + C      L+ S+ +QS
Sbjct: 73  ESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQS 132

Query: 129 ELGDFHEETDRK-HLAQTRYLP---------NQDCLEGKIMHFHQKHIGRSPAESDILLL 178
           + GDF++E  +  +LA  + LP         N+D  E +I  +H++H G    ++ +  L
Sbjct: 133 KYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYL 192

Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINT---FNWAKIRKLSFKR 235
            IA+ L+MYG+      + +G ++ L V  +G+ +   N ++     F W++IR +SF  
Sbjct: 193 KIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFND 252

Query: 236 KHFLIK-----------------LHANILVLCKDTLEFTMASR 261
           K F+IK                 ++  IL LC    E  M  R
Sbjct: 253 KKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRR 295


>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
           [Homo sapiens]
          Length = 1174

 Score =  122 bits (307), Expect = 9e-28
 Identities = 78/288 (27%), Positives = 139/288 (48%), Gaps = 15/288 (5%)

Query: 5   KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
           ++Q L++    F +  +S+G+         L L E  YF L + +      W++L KP+ 
Sbjct: 26  RIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLK 85

Query: 65  KQV-KNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVS 123
           KQ+ K   E    F V F+      L++E+TRY + LQ+KKD+  G +PC+      +  
Sbjct: 86  KQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAG 145

Query: 124 HILQSELGDFHEETDRKHLAQ-----TRYLPNQDCLE---GKIMHFHQKHIGRSPAESDI 175
             +Q++ GDF +   +  L +       +L ++  LE    K+   HQK+ G +  ++++
Sbjct: 146 LAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDAEM 205

Query: 176 LLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN-TFNWAKIRKLSFK 234
           L +    ++D YG   +PA D +G  I +     G+ V   N +    F W  I  +S  
Sbjct: 206 LYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHN 265

Query: 235 RKHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSE 282
           +  F ++L AN     ++T++F     +  K  W+ CV  H F+RL++
Sbjct: 266 KSFFALEL-AN----KEETIQFQTEDMETAKYIWRLCVARHKFYRLNQ 308


>gi|161702986 ezrin [Homo sapiens]
          Length = 586

 Score =  117 bits (292), Expect = 5e-26
 Identities = 85/322 (26%), Positives = 155/322 (48%), Gaps = 19/322 (5%)

Query: 11  DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
           D++  F +   ++GK LF+     + L E  YFGL +  + G   WL+L K ++ Q V+ 
Sbjct: 13  DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72

Query: 70  PKEIVFKFMVKFFPVDPG-HLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
              + FKF  KF+P D    L +++T+ LF LQ+K+ +    + C      L+ S+ +Q+
Sbjct: 73  ENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQA 132

Query: 129 ELGDFHEETDRK-HLAQTRYLP---------NQDCLEGKIMHFHQKHIGRSPAESDILLL 178
           + GD+++E  +  +L+  R +P          +D  E +I  +H +H G     + +  L
Sbjct: 133 KFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYL 192

Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINT---FNWAKIRKLSFKR 235
            IA+ L+MYGI      + +G  + L V  +G+ +   + K+     F W++IR +SF  
Sbjct: 193 KIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFND 252

Query: 236 KHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSK 295
           K F+IK    I     D + +    R   K   + C+  H  +    +P +     + ++
Sbjct: 253 KKFVIK---PIDKKAPDFVFYAPRLR-INKRILQLCMGNHELYMRRRKPDTIEVQQMKAQ 308

Query: 296 GSSFRYSGRTQRQLLEYGRKGR 317
               ++  + +RQ LE  +K R
Sbjct: 309 AREEKHQKQLERQQLETEKKRR 330


>gi|21614499 ezrin [Homo sapiens]
          Length = 586

 Score =  117 bits (292), Expect = 5e-26
 Identities = 85/322 (26%), Positives = 155/322 (48%), Gaps = 19/322 (5%)

Query: 11  DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
           D++  F +   ++GK LF+     + L E  YFGL +  + G   WL+L K ++ Q V+ 
Sbjct: 13  DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72

Query: 70  PKEIVFKFMVKFFPVDPG-HLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
              + FKF  KF+P D    L +++T+ LF LQ+K+ +    + C      L+ S+ +Q+
Sbjct: 73  ENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQA 132

Query: 129 ELGDFHEETDRK-HLAQTRYLP---------NQDCLEGKIMHFHQKHIGRSPAESDILLL 178
           + GD+++E  +  +L+  R +P          +D  E +I  +H +H G     + +  L
Sbjct: 133 KFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYL 192

Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINT---FNWAKIRKLSFKR 235
            IA+ L+MYGI      + +G  + L V  +G+ +   + K+     F W++IR +SF  
Sbjct: 193 KIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFND 252

Query: 236 KHFLIKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSK 295
           K F+IK    I     D + +    R   K   + C+  H  +    +P +     + ++
Sbjct: 253 KKFVIK---PIDKKAPDFVFYAPRLR-INKRILQLCMGNHELYMRRRKPDTIEVQQMKAQ 308

Query: 296 GSSFRYSGRTQRQLLEYGRKGR 317
               ++  + +RQ LE  +K R
Sbjct: 309 AREEKHQKQLERQQLETEKKRR 330


>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score =  111 bits (277), Expect = 3e-24
 Identities = 78/284 (27%), Positives = 141/284 (49%), Gaps = 22/284 (7%)

Query: 11  DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
           D++  F  + K  GK LF+L C  L L E  +FGL++ +      WL++ K +    V  
Sbjct: 30  DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY-TIKDTVAWLKMDKKVLDHDVSK 88

Query: 70  PKEIVFKFMVKFFPVDPGH-LREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
            + + F F+ KF+P +    L +E+T++LF LQ+KK +   ++ C    + L+ S+ +Q+
Sbjct: 89  EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148

Query: 129 ELGDFHEETDRK-HLAQTRYLPNQ---------DCLEGKIMHFHQKHIGRSPAESDILLL 178
           + GD+     ++  LAQ   LP +         +  E +I  ++ +H GR+  E+++  L
Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208

Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN---TFNWAKIRKLSFKR 235
            IA+ L+MYG+      + +G ++ L V  +G+ +     ++    +F W +IR +S+  
Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268

Query: 236 KHFLIK-LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFF 278
           K F IK L   I     D  +F  +     K   + C+  H  F
Sbjct: 269 KEFTIKPLDKKI-----DVFKFNSSKLRVNKLILQLCIGNHDLF 307


>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score =  111 bits (277), Expect = 3e-24
 Identities = 78/284 (27%), Positives = 141/284 (49%), Gaps = 22/284 (7%)

Query: 11  DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
           D++  F  + K  GK LF+L C  L L E  +FGL++ +      WL++ K +    V  
Sbjct: 30  DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY-TIKDTVAWLKMDKKVLDHDVSK 88

Query: 70  PKEIVFKFMVKFFPVDPGH-LREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
            + + F F+ KF+P +    L +E+T++LF LQ+KK +   ++ C    + L+ S+ +Q+
Sbjct: 89  EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148

Query: 129 ELGDFHEETDRK-HLAQTRYLPNQ---------DCLEGKIMHFHQKHIGRSPAESDILLL 178
           + GD+     ++  LAQ   LP +         +  E +I  ++ +H GR+  E+++  L
Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208

Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN---TFNWAKIRKLSFKR 235
            IA+ L+MYG+      + +G ++ L V  +G+ +     ++    +F W +IR +S+  
Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268

Query: 236 KHFLIK-LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFF 278
           K F IK L   I     D  +F  +     K   + C+  H  F
Sbjct: 269 KEFTIKPLDKKI-----DVFKFNSSKLRVNKLILQLCIGNHDLF 307


>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score =  111 bits (277), Expect = 3e-24
 Identities = 78/284 (27%), Positives = 141/284 (49%), Gaps = 22/284 (7%)

Query: 11  DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
           D++  F  + K  GK LF+L C  L L E  +FGL++ +      WL++ K +    V  
Sbjct: 30  DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY-TIKDTVAWLKMDKKVLDHDVSK 88

Query: 70  PKEIVFKFMVKFFPVDPGH-LREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
            + + F F+ KF+P +    L +E+T++LF LQ+KK +   ++ C    + L+ S+ +Q+
Sbjct: 89  EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148

Query: 129 ELGDFHEETDRK-HLAQTRYLPNQ---------DCLEGKIMHFHQKHIGRSPAESDILLL 178
           + GD+     ++  LAQ   LP +         +  E +I  ++ +H GR+  E+++  L
Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208

Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN---TFNWAKIRKLSFKR 235
            IA+ L+MYG+      + +G ++ L V  +G+ +     ++    +F W +IR +S+  
Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268

Query: 236 KHFLIK-LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFF 278
           K F IK L   I     D  +F  +     K   + C+  H  F
Sbjct: 269 KEFTIKPLDKKI-----DVFKFNSSKLRVNKLILQLCIGNHDLF 307


>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
          Length = 595

 Score =  111 bits (277), Expect = 3e-24
 Identities = 78/284 (27%), Positives = 141/284 (49%), Gaps = 22/284 (7%)

Query: 11  DSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITKQ-VKN 69
           D++  F  + K  GK LF+L C  L L E  +FGL++ +      WL++ K +    V  
Sbjct: 30  DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQY-TIKDTVAWLKMDKKVLDHDVSK 88

Query: 70  PKEIVFKFMVKFFPVDPGH-LREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHILQS 128
            + + F F+ KF+P +    L +E+T++LF LQ+KK +   ++ C    + L+ S+ +Q+
Sbjct: 89  EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148

Query: 129 ELGDFHEETDRK-HLAQTRYLPNQ---------DCLEGKIMHFHQKHIGRSPAESDILLL 178
           + GD+     ++  LAQ   LP +         +  E +I  ++ +H GR+  E+++  L
Sbjct: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208

Query: 179 DIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKIN---TFNWAKIRKLSFKR 235
            IA+ L+MYG+      + +G ++ L V  +G+ +     ++    +F W +IR +S+  
Sbjct: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268

Query: 236 KHFLIK-LHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFF 278
           K F IK L   I     D  +F  +     K   + C+  H  F
Sbjct: 269 KEFTIKPLDKKI-----DVFKFNSSKLRVNKLILQLCIGNHDLF 307


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,690,277
Number of Sequences: 37866
Number of extensions: 1366876
Number of successful extensions: 3662
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 3478
Number of HSP's gapped (non-prelim): 79
length of query: 714
length of database: 18,247,518
effective HSP length: 109
effective length of query: 605
effective length of database: 14,120,124
effective search space: 8542675020
effective search space used: 8542675020
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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