Guide to the Human Genome
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Search of human proteins with 34482047

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|34482047 adaptor-related protein complex 3, beta 2 subunit
[Homo sapiens]
         (1082 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|34482047 adaptor-related protein complex 3, beta 2 subunit [H...  2104   0.0  
gi|32484979 adaptor-related protein complex 3, beta 1 subunit [H...  1276   0.0  
gi|71773106 adaptor-related protein complex 2, beta 1 subunit is...   280   7e-75
gi|4557469 adaptor-related protein complex 2, beta 1 subunit iso...   280   7e-75
gi|22027651 adaptor-related protein complex 1 beta 1 subunit iso...   279   9e-75
gi|22027653 adaptor-related protein complex 1 beta 1 subunit iso...   279   9e-75
gi|166197671 adaptor-related protein complex 4, beta 1 subunit [...   179   1e-44
gi|55741677 SET domain containing 1A [Homo sapiens]                    71   6e-12
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    70   1e-11
gi|221316632 coatomer protein complex, subunit beta 1 [Homo sapi...    69   3e-11
gi|221316630 coatomer protein complex, subunit beta 1 [Homo sapi...    69   3e-11
gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens]     69   3e-11
gi|210032580 SET domain containing 1B [Homo sapiens]                   68   5e-11
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]     67   1e-10
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]     67   1e-10
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...    67   1e-10
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...    67   1e-10
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...    67   1e-10
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...    67   1e-10
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...    67   1e-10
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...    64   6e-10
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]         64   8e-10
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    61   5e-09
gi|115529449 upstream binding transcription factor, RNA polymera...    61   7e-09
gi|115529451 upstream binding transcription factor, RNA polymera...    61   7e-09
gi|7657671 upstream binding transcription factor, RNA polymerase...    61   7e-09
gi|217330641 IWS1 homolog [Homo sapiens]                               60   1e-08
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex...    59   3e-08
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu...    58   4e-08
gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2 pre...    58   4e-08

>gi|34482047 adaptor-related protein complex 3, beta 2 subunit [Homo
            sapiens]
          Length = 1082

 Score = 2104 bits (5452), Expect = 0.0
 Identities = 1082/1082 (100%), Positives = 1082/1082 (100%)

Query: 1    MSAAPAYSEDKGGSAGPGEPEYGHDPASGGIFSSDYKRHDDLKEMLDTNKDSLKLEAMKR 60
            MSAAPAYSEDKGGSAGPGEPEYGHDPASGGIFSSDYKRHDDLKEMLDTNKDSLKLEAMKR
Sbjct: 1    MSAAPAYSEDKGGSAGPGEPEYGHDPASGGIFSSDYKRHDDLKEMLDTNKDSLKLEAMKR 60

Query: 61   IVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLK 120
            IVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLK
Sbjct: 61   IVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLK 120

Query: 121  DPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSLDSDQK 180
            DPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSLDSDQK
Sbjct: 121  DPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSLDSDQK 180

Query: 181  DQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERIDLIHKNYRKLCNLLIDVEEWGQVVII 240
            DQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERIDLIHKNYRKLCNLLIDVEEWGQVVII
Sbjct: 181  DQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERIDLIHKNYRKLCNLLIDVEEWGQVVII 240

Query: 241  SMLTRYARTQFLSPTQNESLLEENAEKAFYGSEEDEAKGAGSEETAAAAAPSRKPYVMDP 300
            SMLTRYARTQFLSPTQNESLLEENAEKAFYGSEEDEAKGAGSEETAAAAAPSRKPYVMDP
Sbjct: 241  SMLTRYARTQFLSPTQNESLLEENAEKAFYGSEEDEAKGAGSEETAAAAAPSRKPYVMDP 300

Query: 301  DHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKAEVGVIAKALVRLLRSHSEVQYVVLQ 360
            DHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKAEVGVIAKALVRLLRSHSEVQYVVLQ
Sbjct: 301  DHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKAEVGVIAKALVRLLRSHSEVQYVVLQ 360

Query: 361  NVATMSIKRRGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRS 420
            NVATMSIKRRGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRS
Sbjct: 361  NVATMSIKRRGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRS 420

Query: 421  MDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQ 480
            MDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQ
Sbjct: 421  MDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQ 480

Query: 481  HGEIIKHLAKLTDNIQVPMARASILWLIGEYCEHVPRIAPDVLRKMAKSFTAEEDIVKLQ 540
            HGEIIKHLAKLTDNIQVPMARASILWLIGEYCEHVPRIAPDVLRKMAKSFTAEEDIVKLQ
Sbjct: 481  HGEIIKHLAKLTDNIQVPMARASILWLIGEYCEHVPRIAPDVLRKMAKSFTAEEDIVKLQ 540

Query: 541  VINLAAKLYLTNSKQTKLLTQYVLSLAKYDQNYDIRDRARFTRQLIVPSEQGGALSRHAK 600
            VINLAAKLYLTNSKQTKLLTQYVLSLAKYDQNYDIRDRARFTRQLIVPSEQGGALSRHAK
Sbjct: 541  VINLAAKLYLTNSKQTKLLTQYVLSLAKYDQNYDIRDRARFTRQLIVPSEQGGALSRHAK 600

Query: 601  KLFLAPKPAPVLESSFKDRDHFQLGSLSHLLNAKATGYQELPDWPEEAPDPSVRNVEVPE 660
            KLFLAPKPAPVLESSFKDRDHFQLGSLSHLLNAKATGYQELPDWPEEAPDPSVRNVEVPE
Sbjct: 601  KLFLAPKPAPVLESSFKDRDHFQLGSLSHLLNAKATGYQELPDWPEEAPDPSVRNVEVPE 660

Query: 661  WTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDN 720
            WTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDN
Sbjct: 661  WTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDN 720

Query: 721  EDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESE 780
            EDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESE
Sbjct: 721  EDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESE 780

Query: 781  EEQLEPASWSRKTPPSSKSAPATKEISLLDLEDFTPPSVQPVSPPAIVSTSLAADLEGLT 840
            EEQLEPASWSRKTPPSSKSAPATKEISLLDLEDFTPPSVQPVSPPAIVSTSLAADLEGLT
Sbjct: 781  EEQLEPASWSRKTPPSSKSAPATKEISLLDLEDFTPPSVQPVSPPAIVSTSLAADLEGLT 840

Query: 841  LTDSTLVPSLLSPVSGVGRQELLHRVAGEGLAVDYTFSRQPFSGDPHMVSVHIHFSNSSD 900
            LTDSTLVPSLLSPVSGVGRQELLHRVAGEGLAVDYTFSRQPFSGDPHMVSVHIHFSNSSD
Sbjct: 841  LTDSTLVPSLLSPVSGVGRQELLHRVAGEGLAVDYTFSRQPFSGDPHMVSVHIHFSNSSD 900

Query: 901  TPIKGLHVGTPKLPAGISIQEFPEIESLAPGESATAVMGINFCDSTQAANFQLCTQTRQF 960
            TPIKGLHVGTPKLPAGISIQEFPEIESLAPGESATAVMGINFCDSTQAANFQLCTQTRQF
Sbjct: 901  TPIKGLHVGTPKLPAGISIQEFPEIESLAPGESATAVMGINFCDSTQAANFQLCTQTRQF 960

Query: 961  YVSIQPPVGELMAPVFMSENEFKKEQGKLMGMNEITEKLMLPDTCRSDHIVVQKVTATAN 1020
            YVSIQPPVGELMAPVFMSENEFKKEQGKLMGMNEITEKLMLPDTCRSDHIVVQKVTATAN
Sbjct: 961  YVSIQPPVGELMAPVFMSENEFKKEQGKLMGMNEITEKLMLPDTCRSDHIVVQKVTATAN 1020

Query: 1021 LGRVPCGTSDEYRFAGRTLTGGSLVLLTLDARPAGAAQLTVNSEKMVIGTMLVKDVIQAL 1080
            LGRVPCGTSDEYRFAGRTLTGGSLVLLTLDARPAGAAQLTVNSEKMVIGTMLVKDVIQAL
Sbjct: 1021 LGRVPCGTSDEYRFAGRTLTGGSLVLLTLDARPAGAAQLTVNSEKMVIGTMLVKDVIQAL 1080

Query: 1081 TQ 1082
            TQ
Sbjct: 1081 TQ 1082


>gi|32484979 adaptor-related protein complex 3, beta 1 subunit [Homo
            sapiens]
          Length = 1094

 Score = 1276 bits (3301), Expect = 0.0
 Identities = 686/1105 (62%), Positives = 829/1105 (75%), Gaps = 48/1105 (4%)

Query: 7    YSEDKGGSAGPGEPEYGHDPASG-------GIFSSDYKRHDDLKEMLDTNKDSLKLEAMK 59
            Y+E  GG       E G +  S        G+FSSD K+++DLK+ML++NKDS KL+AMK
Sbjct: 8    YNEQSGGGEAT---ELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLESNKDSAKLDAMK 64

Query: 60   RIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGL 119
            RIV MIA+GKNAS+LFPAVVKNVA KNIE+KKLVYVYLVRYAEEQQDLALLSISTFQR L
Sbjct: 65   RIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRAL 124

Query: 120  KDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSLDSDQ 179
            KDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEA++D+SPYVRK AAHAI KLYSLD +Q
Sbjct: 125  KDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQ 184

Query: 180  KDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERIDLIHKNYRKLCNLLIDVEEWGQVVI 239
            K+ LIEVIEKLL DK+TLVAGSVVMAFEEVCP+RIDLIHKNYRKLCNLL+DVEEWGQVVI
Sbjct: 185  KEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVI 244

Query: 240  ISMLTRYARTQFLSPTQNESLLEENAEKAFYGSEEDEAKGAGSEETAAAAAPSRKPYVMD 299
            I MLTRYARTQF+SP +    LE+N  K FY S++D+ +    +         +KPY MD
Sbjct: 245  IHMLTRYARTQFVSPWKEGDELEDNG-KNFYESDDDQKEKTDKK---------KKPYTMD 294

Query: 300  PDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKAEVGVIAKALVRLLRSHSEVQYVVL 359
            PDHRLL+RNTKPLLQSR+AAVVMAVAQLY+H++PK+E G+I+K+LVRLLRS+ EVQY+VL
Sbjct: 295  PDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVL 354

Query: 360  QNVATMSIKRRGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPTVLREFQTYIR 419
            QN+ATMSI+R+GMFEPYLKSFY+RSTDPT IK LKLE+LTNLANE NI T+LREFQTY++
Sbjct: 355  QNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVK 414

Query: 420  SMDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPA 479
            S DK F AATIQ IGRCATNI  V DTCLNGLV LLSNRDE+VVAESVVVIKKLLQMQPA
Sbjct: 415  SQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPA 474

Query: 480  QHGEIIKHLAKLTDNIQVPMARASILWLIGEYCEHVPRIAPDVLRKMAKSFTAEEDIVKL 539
            QHGEIIKH+AKL D+I VP+ARASILWLIGE CE VP+IAPDVLRKMAKSFT+E+D+VKL
Sbjct: 475  QHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKL 534

Query: 540  QVINLAAKLYLTNSKQTKLLTQYVLSLAKYDQNYDIRDRARFTRQLIVPSEQGGALSRHA 599
            Q++NL AKLYLTNSKQTKLLTQY+L+L KYDQNYDIRDR RF RQLIVP+ + GALS++A
Sbjct: 535  QILNLGAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKYA 594

Query: 600  KKLFLAPKPAPVLESSFKDRDHFQLGSLSHLLNAKATGYQELPDWPEEAPDPSVRNVEV- 658
            KK+FLA KPAP+LES FKDRDHFQLG+LSH LN KATGY EL +WPE APDPSVRNVEV 
Sbjct: 595  KKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVI 654

Query: 659  ---PEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESS 715
                EWT  + + K++   K FYS+SE E    +S+DS  +SESES S+S  +  SGE  
Sbjct: 655  ELAKEWTP-AGKAKQENSAKKFYSESEEEE---DSSDSSSDSESESGSESGEQGESGEEG 710

Query: 716  SESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASS------------SDEG 763
                NED  ED    + SES +      ++T K+  + KG++ S            SD  
Sbjct: 711  --DSNEDSSEDSSSEQDSESGRESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSS 768

Query: 764  SDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSKS-----APATKEISLLDLEDFTPPS 818
            +D SSS  +S   SESE E    +   R T    K       P TK++SLLDL+DF P S
Sbjct: 769  NDESSSIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLDLDDFNPVS 828

Query: 819  VQPVSPPAIVSTSLAADLEGLTLTDSTLVPSLLSPVSGVGRQE-LLHRVAGEGLAVDYTF 877
                 P   +S SL ADLEGL L+ S+ V S+ +P     +   LLHR++G+GLA  Y F
Sbjct: 829  TPVALPTPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFF 888

Query: 878  SRQPFSGDPHMVSVHIHFSNSSDTPIKGLHVGTPKLPAGISIQEFPEIESLAPGESATAV 937
             RQP      MVS+ I  +N++D  I+ +H+G  KLP G+ +  F  I+SL P  S T  
Sbjct: 889  PRQPCIFGDKMVSIQITLNNTTDRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVS 948

Query: 938  MGINFCDSTQAANFQLCTQTRQFYVSIQPPVGELMAPVFMSENEFKKEQGKLMGMNEITE 997
            MGI+FCDSTQ A+FQLCT+   F V+IQPPVGEL+ PV MSE +FKKEQG L GMNE + 
Sbjct: 949  MGIDFCDSTQTASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSA 1008

Query: 998  KLMLPDTCRSDHIVVQKVTATANLGRVPCGTSDEYRFAGRTLTGGSLVLLTLDARPAGAA 1057
             ++      +  ++ QKV   AN+G VP G  + +RFA +T+  GSL+L+T++ +    A
Sbjct: 1009 VIIAAPQNFTPSVIFQKVVNVANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTA 1068

Query: 1058 QLTVNSEKMVIGTMLVKDVIQALTQ 1082
            QL +N+EK VIG++L++++   L+Q
Sbjct: 1069 QLIINTEKTVIGSVLLRELKPVLSQ 1093


>gi|71773106 adaptor-related protein complex 2, beta 1 subunit
           isoform a [Homo sapiens]
          Length = 951

 Score =  280 bits (715), Expect = 7e-75
 Identities = 188/621 (30%), Positives = 313/621 (50%), Gaps = 75/621 (12%)

Query: 41  DLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRY 100
           +LK  L+  K   + EA+K+++A +  GK+ S LFP VV  +   N+E+KKLVY+YL+ Y
Sbjct: 17  ELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNY 76

Query: 101 AEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPY 160
           A+ Q D+A++++++F +  +DPN LIRA A+R +  IRV  I   +   +++   D  PY
Sbjct: 77  AKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPY 136

Query: 161 VRKTAAHAIPKLYSLDSDQ-KDQ-LIEVIEKLLADKTTLVAGSVVMAFEEVCPER----- 213
           VRKTAA  + KL+ +++   +DQ  ++ +  L+AD   +V  + V A  E+         
Sbjct: 137 VRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNL 196

Query: 214 IDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAFYGSE 273
           +DL  +N  KL   L +  EWGQ+ I+  L+ Y                         + 
Sbjct: 197 LDLNPQNINKLLTALNECTEWGQIFILDCLSNY-------------------------NP 231

Query: 274 EDEAKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQL--YFHL 331
           +D+ +     E                      R T  L  + SA V+ AV  L  +  L
Sbjct: 232 KDDREAQSICE----------------------RVTPRLSHANSAVVLSAVKVLMKFLEL 269

Query: 332 APKAE------VGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRST 385
            PK        +  +A  LV LL    EVQYV L+N+  +  KR  + +  +K F+++  
Sbjct: 270 LPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYN 329

Query: 386 DPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRD 445
           DP  +K+ KL+++  LA++ NI  VL E + Y   +D DFV   ++AIGRCA  + +  +
Sbjct: 330 DPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389

Query: 446 TCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASIL 505
            C++ L+ L+  +   VV E++VVI+ + +  P ++  II  L +  D++  P ARA+++
Sbjct: 390 RCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMI 449

Query: 506 WLIGEYCEHVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLS 565
           W++GEY E +   A ++L    + F  E   V+L ++    KL+L    +T+ L Q VLS
Sbjct: 450 WIVGEYAERIDN-ADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLS 508

Query: 566 LAKYD-QNYDIRDRARFTRQLIVPSEQGGALSRHAKKLFLAPKP-----APVLESSFKDR 619
           LA  D  N D+RDR     +L+            AK++ L+ KP       ++E +  D 
Sbjct: 509 LATQDSDNPDLRDRGYIYWRLLSTDPV------TAKEVVLSEKPLISEETDLIEPTLLDE 562

Query: 620 DHFQLGSLSHLLNAKATGYQE 640
               +GSL+ + +     + E
Sbjct: 563 LICHIGSLASVYHKPPNAFVE 583


>gi|4557469 adaptor-related protein complex 2, beta 1 subunit
           isoform b [Homo sapiens]
          Length = 937

 Score =  280 bits (715), Expect = 7e-75
 Identities = 188/621 (30%), Positives = 313/621 (50%), Gaps = 75/621 (12%)

Query: 41  DLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRY 100
           +LK  L+  K   + EA+K+++A +  GK+ S LFP VV  +   N+E+KKLVY+YL+ Y
Sbjct: 17  ELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNY 76

Query: 101 AEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPY 160
           A+ Q D+A++++++F +  +DPN LIRA A+R +  IRV  I   +   +++   D  PY
Sbjct: 77  AKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPY 136

Query: 161 VRKTAAHAIPKLYSLDSDQ-KDQ-LIEVIEKLLADKTTLVAGSVVMAFEEVCPER----- 213
           VRKTAA  + KL+ +++   +DQ  ++ +  L+AD   +V  + V A  E+         
Sbjct: 137 VRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNL 196

Query: 214 IDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAFYGSE 273
           +DL  +N  KL   L +  EWGQ+ I+  L+ Y                         + 
Sbjct: 197 LDLNPQNINKLLTALNECTEWGQIFILDCLSNY-------------------------NP 231

Query: 274 EDEAKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQL--YFHL 331
           +D+ +     E                      R T  L  + SA V+ AV  L  +  L
Sbjct: 232 KDDREAQSICE----------------------RVTPRLSHANSAVVLSAVKVLMKFLEL 269

Query: 332 APKAE------VGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRST 385
            PK        +  +A  LV LL    EVQYV L+N+  +  KR  + +  +K F+++  
Sbjct: 270 LPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYN 329

Query: 386 DPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRD 445
           DP  +K+ KL+++  LA++ NI  VL E + Y   +D DFV   ++AIGRCA  + +  +
Sbjct: 330 DPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389

Query: 446 TCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASIL 505
            C++ L+ L+  +   VV E++VVI+ + +  P ++  II  L +  D++  P ARA+++
Sbjct: 390 RCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMI 449

Query: 506 WLIGEYCEHVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLS 565
           W++GEY E +   A ++L    + F  E   V+L ++    KL+L    +T+ L Q VLS
Sbjct: 450 WIVGEYAERIDN-ADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLS 508

Query: 566 LAKYD-QNYDIRDRARFTRQLIVPSEQGGALSRHAKKLFLAPKP-----APVLESSFKDR 619
           LA  D  N D+RDR     +L+            AK++ L+ KP       ++E +  D 
Sbjct: 509 LATQDSDNPDLRDRGYIYWRLLSTDPV------TAKEVVLSEKPLISEETDLIEPTLLDE 562

Query: 620 DHFQLGSLSHLLNAKATGYQE 640
               +GSL+ + +     + E
Sbjct: 563 LICHIGSLASVYHKPPNAFVE 583


>gi|22027651 adaptor-related protein complex 1 beta 1 subunit
           isoform a [Homo sapiens]
          Length = 949

 Score =  279 bits (714), Expect = 9e-75
 Identities = 184/613 (30%), Positives = 317/613 (51%), Gaps = 59/613 (9%)

Query: 41  DLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRY 100
           +LK  L+++K   K EA+K+++A +  GK+ S LFP VV  +   N+E+KKLVY+YL+ Y
Sbjct: 17  ELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNY 76

Query: 101 AEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPY 160
           A+ Q D+A+++++TF +  +DPN LIRA A+R +  IRV  I   +   +++   D  PY
Sbjct: 77  AKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPY 136

Query: 161 VRKTAAHAIPKLYSLDSDQ-KDQ-LIEVIEKLLADKTTLVAGSVVMAFEEVCPER----- 213
           VRKTAA  + KL+ +++   +DQ  ++ ++ L++D   +V  + V A  E+         
Sbjct: 137 VRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNL 196

Query: 214 IDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAFYGSE 273
           +DL  ++  KL   L +  EWGQ+ I+  L  Y                          +
Sbjct: 197 LDLNPQSINKLLTALNECTEWGQIFILDCLANYMP-----------------------KD 233

Query: 274 EDEAKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAP 333
           + EA+      T         P +   +  ++L   K L++     ++      Y  L  
Sbjct: 234 DREAQSICERVT---------PRLSHANSAVVLSAVKVLMKFME--MLSKDLDYYGTLLK 282

Query: 334 KAEVGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQIKIL 393
           K     +A  LV LL +  E+QYV L+N+  +  KR  + +  +K F+++  DP  +K+ 
Sbjct: 283 K-----LAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLE 337

Query: 394 KLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQ 453
           KL+++  LA++ NI  VL E + Y   +D DFV   ++AIGRCA  + +  + C++ L+ 
Sbjct: 338 KLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLD 397

Query: 454 LLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCE 513
           L+  +   VV E++VVIK + +  P ++  +I  L +  D++  P ARA+++W++GEY E
Sbjct: 398 LIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAE 457

Query: 514 HVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSLAKYD-QN 572
            +   A ++L    + F  E   V+LQ++    KL+L    +T+ L Q VLSLA  D  N
Sbjct: 458 RIDN-ADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDN 516

Query: 573 YDIRDRARFTRQLIVPSEQGGALSRHAKKLFLAPKP-----APVLESSFKDRDHFQLGSL 627
            D+RDR     +L+            AK++ LA KP       ++E +  D     +G+L
Sbjct: 517 PDLRDRGYIYWRLLSTDPVA------AKEVVLAEKPLISEETDLIEPTLLDELICYIGTL 570

Query: 628 SHLLNAKATGYQE 640
           + + +   + + E
Sbjct: 571 ASVYHKPPSAFVE 583


>gi|22027653 adaptor-related protein complex 1 beta 1 subunit
           isoform b [Homo sapiens]
          Length = 942

 Score =  279 bits (714), Expect = 9e-75
 Identities = 184/613 (30%), Positives = 317/613 (51%), Gaps = 59/613 (9%)

Query: 41  DLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRY 100
           +LK  L+++K   K EA+K+++A +  GK+ S LFP VV  +   N+E+KKLVY+YL+ Y
Sbjct: 17  ELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNY 76

Query: 101 AEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPY 160
           A+ Q D+A+++++TF +  +DPN LIRA A+R +  IRV  I   +   +++   D  PY
Sbjct: 77  AKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPY 136

Query: 161 VRKTAAHAIPKLYSLDSDQ-KDQ-LIEVIEKLLADKTTLVAGSVVMAFEEVCPER----- 213
           VRKTAA  + KL+ +++   +DQ  ++ ++ L++D   +V  + V A  E+         
Sbjct: 137 VRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNL 196

Query: 214 IDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAFYGSE 273
           +DL  ++  KL   L +  EWGQ+ I+  L  Y                          +
Sbjct: 197 LDLNPQSINKLLTALNECTEWGQIFILDCLANYMP-----------------------KD 233

Query: 274 EDEAKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAP 333
           + EA+      T         P +   +  ++L   K L++     ++      Y  L  
Sbjct: 234 DREAQSICERVT---------PRLSHANSAVVLSAVKVLMKFME--MLSKDLDYYGTLLK 282

Query: 334 KAEVGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQIKIL 393
           K     +A  LV LL +  E+QYV L+N+  +  KR  + +  +K F+++  DP  +K+ 
Sbjct: 283 K-----LAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLE 337

Query: 394 KLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQ 453
           KL+++  LA++ NI  VL E + Y   +D DFV   ++AIGRCA  + +  + C++ L+ 
Sbjct: 338 KLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLD 397

Query: 454 LLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCE 513
           L+  +   VV E++VVIK + +  P ++  +I  L +  D++  P ARA+++W++GEY E
Sbjct: 398 LIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAE 457

Query: 514 HVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSLAKYD-QN 572
            +   A ++L    + F  E   V+LQ++    KL+L    +T+ L Q VLSLA  D  N
Sbjct: 458 RIDN-ADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDN 516

Query: 573 YDIRDRARFTRQLIVPSEQGGALSRHAKKLFLAPKP-----APVLESSFKDRDHFQLGSL 627
            D+RDR     +L+            AK++ LA KP       ++E +  D     +G+L
Sbjct: 517 PDLRDRGYIYWRLLSTDPVA------AKEVVLAEKPLISEETDLIEPTLLDELICYIGTL 570

Query: 628 SHLLNAKATGYQE 640
           + + +   + + E
Sbjct: 571 ASVYHKPPSAFVE 583


>gi|166197671 adaptor-related protein complex 4, beta 1 subunit
           [Homo sapiens]
          Length = 739

 Score =  179 bits (455), Expect = 1e-44
 Identities = 145/568 (25%), Positives = 257/568 (45%), Gaps = 71/568 (12%)

Query: 58  MKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQR 117
           ++R++  + +G + S +F  +VK  A  +I  KKLVY+Y+  YA  + DLALL+I+T  +
Sbjct: 33  IQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLAINTLCK 92

Query: 118 GLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSL-- 175
              DPN ++R  ALR + S+R+P +   +   I     D + YVR+ A     K+++L  
Sbjct: 93  DCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVLGCAKMHNLHG 152

Query: 176 DSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERIDLIHKN--YRKLCNLLIDVEE 233
           DS+    L+  +  LL D+  +V  + + + EE+  +   ++        L N +  +++
Sbjct: 153 DSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVINKPIAHHLLNRMSKLDQ 212

Query: 234 WGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAFYGSEEDEAKGAGSEETAAAAAPSR 293
           WGQ  +++ L RY       P   E L +                               
Sbjct: 213 WGQAEVLNFLLRY------QPRSEEELFD------------------------------- 235

Query: 294 KPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLA---PKAEVGVIAKALVRLLRS 350
                      +L      L+S S  VVM   +L+  LA   P  +  V+ +    LL +
Sbjct: 236 -----------ILNLLDSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAA 284

Query: 351 HS----EVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETN 406
            S    E+ +V L +V  +     G F  + K F+   ++P  IK+ K+EVL  L N+ N
Sbjct: 285 CSSESRELCFVALCHVRQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDEN 344

Query: 407 IPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELVVAES 466
           +  VL E + Y   +  DF  A I AIG  A       D C+  L +LL  R E +    
Sbjct: 345 VQQVLEELRGYCTDVSADFAQAAIFAIGGIART---YTDQCVQILTELLGLRQEHITTVV 401

Query: 467 VVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCEHVPRIAPDVLRKM 526
           V   + L+ + P     + + L    +NIQ    + +++WL+G + E +P  AP VL   
Sbjct: 402 VQTFRDLVWLCPQCTEAVCQALPGCEENIQDSEGKQALIWLLGVHGERIPN-APYVLEDF 460

Query: 527 AKSFTAEE-DIVKLQVINLAAKLYLTNSKQTK-LLTQYVLSLAKYDQNYDIRDRARFTRQ 584
            ++  +E    VK++++    +L+L+   + + +L + +    + +++  +RDR  F  +
Sbjct: 461 VENVKSETFPAVKMELLTALLRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYR 520

Query: 585 LIVPSEQGGALSRHAKKLFLAPKPAPVL 612
           L++            K++  +PK  P L
Sbjct: 521 LLLVGID------EVKRILCSPKSDPTL 542


>gi|55741677 SET domain containing 1A [Homo sapiens]
          Length = 1707

 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 55/192 (28%), Positives = 86/192 (44%), Gaps = 10/192 (5%)

Query: 642  PDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESES 701
            P+  +EA +P     + P+  +   + + K + K F  DSEGE    ES+    E + E 
Sbjct: 925  PEQEKEAGEPGRPGTKPPKRDEERGKTQGKHR-KSFALDSEGEEASQESSSEKDEEDDEE 983

Query: 702  DSKSSSESGSGESSSESDNEDQDEDEEKGRGSE-SEQSEEDGKRKTKKKVPERKGEASSS 760
            D +      + +++ +       EDEE    S+ S  ++ DG+  +          +SSS
Sbjct: 984  DEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSS 1043

Query: 761  DEGSDSSS--SSSESEMTSESEEEQLEPASWSRKTPPSSK---SAPATKEISLLDL---E 812
               S SSS  SSS SE +SE EEE+  PA+    +PP  +     PA  E+ + +     
Sbjct: 1044 SSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGS 1103

Query: 813  DFTPPSVQPVSP 824
              TP   Q  SP
Sbjct: 1104 PVTPLPEQEASP 1115



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 63/236 (26%), Positives = 84/236 (35%), Gaps = 45/236 (19%)

Query: 637  GYQELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDS-----EGESGPTESA 691
            G   LP +  +  +PS    E+ E    ++ EKR     P   D      E E+G     
Sbjct: 886  GALRLPSFKVKRKEPS----EISE----ASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRP 937

Query: 692  DSDPESESESDSK------------SSSESGSGESSSESDNEDQDEDEE----------- 728
             + P    E   K            S  E  S ESSSE D ED +EDEE           
Sbjct: 938  GTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTT 997

Query: 729  --KGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEP 786
              +   S+ E  E D   K      +  GE  S+ +   SSSSSS S  +S S       
Sbjct: 998  KKETEVSDGEDEESDSSSKCSLYA-DSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSS 1056

Query: 787  ASWSRKTPPSSKSAPATKEISLLDLEDFTPPSVQPVSPPAIVSTSLAADLEGLTLT 842
            +S S       +  PA    +        PP   PV  PA V   +   + G  +T
Sbjct: 1057 SSESSSEDEEEEERPAALPSA------SPPPREVPVPTPAPVEVPVPERVAGSPVT 1106



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 36/167 (21%), Positives = 56/167 (33%), Gaps = 18/167 (10%)

Query: 678 YSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQ 737
           ++    +  P  S  S P S+  + S S++ +      SE+  +D          S S  
Sbjct: 263 FTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTT 322

Query: 738 SEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSES-------------EEEQL 784
           +       T          +S S   S SSSSSS    +S++                  
Sbjct: 323 ASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSY 382

Query: 785 EPASWSRKTPPSSKSAPATKEISLLDLEDFTP-----PSVQPVSPPA 826
            P   +R+ PP +  A  T E        + P     P+ Q   PPA
Sbjct: 383 PPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPA 429



 Score = 30.4 bits (67), Expect = 9.4
 Identities = 19/76 (25%), Positives = 31/76 (40%), Gaps = 9/76 (11%)

Query: 726  DEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLE 785
            + E+ +  + +Q  E+G         E +GE    +E  +SS SSS S+         L 
Sbjct: 1345 EAEEPKPQQLQQQREEG---------EEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLR 1395

Query: 786  PASWSRKTPPSSKSAP 801
              +  R+ PP     P
Sbjct: 1396 SHARRRRPPPPPPPPP 1411



 Score = 30.4 bits (67), Expect = 9.4
 Identities = 15/41 (36%), Positives = 18/41 (43%)

Query: 672  EKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSG 712
            E+ KP     + E G  E  +   E E ES   SSS  G G
Sbjct: 1347 EEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEG 1387


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 50/168 (29%), Positives = 77/168 (45%), Gaps = 2/168 (1%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQ-DEDEEKGRGSESEQ 737
           SDS   +  ++S  SD +S   SDS SS  S S +SS  SD+ D  D  +     S+S +
Sbjct: 569 SDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSK 628

Query: 738 SEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSS 797
           SE D      K        + SSD  SDSS SS+ S  +  S+      +S S  +  SS
Sbjct: 629 SESDSSDSDSKSDSSDSNSSDSSDN-SDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSS 687

Query: 798 KSAPATKEISLLDLEDFTPPSVQPVSPPAIVSTSLAADLEGLTLTDST 845
            S+ ++   +  +  D +  S    S  +  S S ++D +    +DS+
Sbjct: 688 DSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSS 735



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 43/142 (30%), Positives = 65/142 (45%), Gaps = 2/142 (1%)

Query: 679  SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
            SDS   S  ++S+DS   SES   S SS+ S S +SS  SD+ D  +  +    S+S  S
Sbjct: 1064 SDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNS 1123

Query: 739  EE--DGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPS 796
             +  D    +         ++S S E SDSS SS  S+ +  S+      +S S  +  S
Sbjct: 1124 SDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS 1183

Query: 797  SKSAPATKEISLLDLEDFTPPS 818
            S S+ ++      D  D +  S
Sbjct: 1184 SDSSDSSDSSDSSDSSDSSDSS 1205



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 41/140 (29%), Positives = 66/140 (47%), Gaps = 1/140 (0%)

Query: 679  SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
            SDS   S  ++S+DS   S+S   S SS  S S +SS  SD+ D  +  +    S+S +S
Sbjct: 1025 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSES 1084

Query: 739  EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSK 798
              D    +         ++S S + SDSS SS  S+ ++ S+      +S S  +  SS 
Sbjct: 1085 -SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSD 1143

Query: 799  SAPATKEISLLDLEDFTPPS 818
            S+ +++     D  D +  S
Sbjct: 1144 SSDSSESSDSSDSSDSSDSS 1163



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 42/145 (28%), Positives = 66/145 (45%), Gaps = 5/145 (3%)

Query: 679  SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
            SDS   S  ++S+DS   S+S   S SS  S S ESS  SD+ D  +  +    S+S  S
Sbjct: 1115 SDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDS 1174

Query: 739  EE-----DGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKT 793
             +     D    +         ++S S + SDSS SS  S+ +  S+      +S S ++
Sbjct: 1175 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNES 1234

Query: 794  PPSSKSAPATKEISLLDLEDFTPPS 818
              SS S+ ++   +  D  D +  S
Sbjct: 1235 SDSSDSSDSSDSSNSSDSSDSSDSS 1259



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 42/142 (29%), Positives = 64/142 (45%), Gaps = 2/142 (1%)

Query: 679  SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
            SDS   S  ++S+DS   S+S   S SS  S S  SS  SD+ D  +  +    S+S  S
Sbjct: 1088 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDS 1147

Query: 739  EE--DGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPS 796
             E  D    +         ++S S + SDSS+SS  S+ +  S+      +S S  +  S
Sbjct: 1148 SESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1207

Query: 797  SKSAPATKEISLLDLEDFTPPS 818
            S S+ ++      D  D +  S
Sbjct: 1208 SDSSDSSDSSDSSDSSDSSDSS 1229



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 48/169 (28%), Positives = 78/169 (46%), Gaps = 4/169 (2%)

Query: 681 SEGESGPTESADSDP-ESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSE 739
           S+   G ++S+DSD  +S + SDS  SS+S S +S+S SD++  D D      S+S  S 
Sbjct: 540 SDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSS 599

Query: 740 EDGKRKTKKKVPERKGEASSSDEGSDSS---SSSSESEMTSESEEEQLEPASWSRKTPPS 796
                       +    + SSD  SDSS   S SS+S+  S+S +     +S +  +  S
Sbjct: 600 NSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDS 659

Query: 797 SKSAPATKEISLLDLEDFTPPSVQPVSPPAIVSTSLAADLEGLTLTDST 845
           S S+ ++      D  D +  S    S  +  S+  +   E    +DS+
Sbjct: 660 SNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSS 708



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 3/141 (2%)

Query: 671 KEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKG 730
           K K     SDS   S  ++S+DS     S+S+S S S+S   +SS  SD++  D      
Sbjct: 544 KGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSD 603

Query: 731 RGSESEQSE-EDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASW 789
               S+ S+  D    +  K    K E+ SSD  SDS S SS+S  +  S+      +S 
Sbjct: 604 SSDSSDSSDSSDSSDSSDSKSDSSKSESDSSD--SDSKSDSSDSNSSDSSDNSDSSDSSN 661

Query: 790 SRKTPPSSKSAPATKEISLLD 810
           S  +  SS S+ ++   S  D
Sbjct: 662 SSNSSDSSDSSDSSDSSSSSD 682



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 46/183 (25%), Positives = 77/183 (42%), Gaps = 2/183 (1%)

Query: 665  SNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQD 724
            SN     +      SDS   S  ++S+DS   S+S   S SS  S S +SS  S++ D  
Sbjct: 963  SNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSS 1022

Query: 725  EDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSD--EGSDSSSSSSESEMTSESEEE 782
               +    S+S  S +           +    ++SSD  + SDSS SS  S+ +  S+  
Sbjct: 1023 NSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1082

Query: 783  QLEPASWSRKTPPSSKSAPATKEISLLDLEDFTPPSVQPVSPPAIVSTSLAADLEGLTLT 842
            +   +S S  +  SS S+ ++      D  D +  S    S  +  S+  +   +    +
Sbjct: 1083 ESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 1142

Query: 843  DST 845
            DS+
Sbjct: 1143 DSS 1145



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 41/154 (26%), Positives = 68/154 (44%), Gaps = 1/154 (0%)

Query: 665  SNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQD 724
            SN            S    +S  ++S+DS   S+S   S SS  S S +SS+ SD+ D  
Sbjct: 951  SNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSS 1010

Query: 725  EDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQL 784
            +  +    S+S  S  D    +         ++S S + SDSS SS+ S+ +  S+    
Sbjct: 1011 DSSDSSNSSDSSNS-SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1069

Query: 785  EPASWSRKTPPSSKSAPATKEISLLDLEDFTPPS 818
              +S S  +  SS+S+ ++   +  D  D +  S
Sbjct: 1070 SDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSS 1103



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 46/182 (25%), Positives = 76/182 (41%), Gaps = 1/182 (0%)

Query: 665  SNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNED-Q 723
            SN     +      SDS   S  ++S+DS   S+S   S SS  S S +SS+ SD+ D  
Sbjct: 889  SNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSS 948

Query: 724  DEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQ 783
            D        + S+ S       +          +S S + SDSS SS  S+ ++ S+   
Sbjct: 949  DSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSD 1008

Query: 784  LEPASWSRKTPPSSKSAPATKEISLLDLEDFTPPSVQPVSPPAIVSTSLAADLEGLTLTD 843
               +S S  +  SS S+ ++      D  D +  S    S  +  S++ +   +    +D
Sbjct: 1009 SSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1068

Query: 844  ST 845
            S+
Sbjct: 1069 SS 1070



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 41/135 (30%), Positives = 59/135 (43%), Gaps = 1/135 (0%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
           SDS   S  ++S+DS   SES SDS  SS+S S +SS  S++   D D      S    +
Sbjct: 681 SDSSNSSDSSDSSDSSNSSES-SDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSN 739

Query: 739 EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSK 798
             D    +         ++S S   SDSS SS  S+ +  S       +S S  +  SS 
Sbjct: 740 SSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSN 799

Query: 799 SAPATKEISLLDLED 813
           S+ ++      D  D
Sbjct: 800 SSDSSNSSDSSDSSD 814



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 38/125 (30%), Positives = 56/125 (44%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
           SDS   S  ++S DS   S+S   S SS  S S +SS  SD+ D D        + S+ S
Sbjct: 774 SDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSS 833

Query: 739 EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSK 798
           +      +        G  S S   SDSS+SS  S+ +  S       +S S ++  SS 
Sbjct: 834 DSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD 893

Query: 799 SAPAT 803
           S+ ++
Sbjct: 894 SSDSS 898



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 46/157 (29%), Positives = 69/157 (43%), Gaps = 1/157 (0%)

Query: 679  SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
            SDS   S  + S+DS   S+S   S SS+ S S +SS  SD+ D  +  +    S+S  S
Sbjct: 1112 SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDS 1171

Query: 739  EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSK 798
              D    +         ++S S + SDSS SS  S+ +  S+      +S S  +  SS 
Sbjct: 1172 -SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1230

Query: 799  SAPATKEISLLDLEDFTPPSVQPVSPPAIVSTSLAAD 835
            S  ++      D  D +  S    S  +  STS + D
Sbjct: 1231 SNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSND 1267



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 39/135 (28%), Positives = 63/135 (46%), Gaps = 1/135 (0%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
           SDS   S  + S+DS   S+S   S SS  S S +SS  SD+ +  E  +    S+S+ S
Sbjct: 654 SDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSS 713

Query: 739 EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSK 798
           +      +     +    + SSD  S+SS SS  S+ ++ S+      +S S  +  SS 
Sbjct: 714 DSSDSSNSNSSDSDSSNSSDSSD-SSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772

Query: 799 SAPATKEISLLDLED 813
           S+ ++   +  D  D
Sbjct: 773 SSDSSDSSNSSDSND 787



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 39/127 (30%), Positives = 59/127 (46%), Gaps = 2/127 (1%)

Query: 679  SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
            SDS   S  + S+DS   S+S   S SS  S S +SS  SD+ D     +    S+S  S
Sbjct: 1046 SDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDS 1105

Query: 739  EE--DGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPS 796
             +  D    +         ++S S + SDSS SS+ S+ +  SE      +S S  +  S
Sbjct: 1106 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDS 1165

Query: 797  SKSAPAT 803
            S S+ ++
Sbjct: 1166 SDSSDSS 1172



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 39/140 (27%), Positives = 65/140 (46%), Gaps = 4/140 (2%)

Query: 679  SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
            S+S   S  ++S+DS   S+S   S SS  S S +SS+ SD+ D  +  +    S+S  S
Sbjct: 1055 SNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1114

Query: 739  EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSK 798
             +               ++S S + SDSS+SS  S+ +  S+      +S S  +  SS 
Sbjct: 1115 SDSSDSSNSSD----SSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSD 1170

Query: 799  SAPATKEISLLDLEDFTPPS 818
            S+ ++   +  D  D +  S
Sbjct: 1171 SSDSSDSSNSSDSSDSSDSS 1190



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 36/125 (28%), Positives = 60/125 (48%), Gaps = 1/125 (0%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
           SDS   S  ++S++S   S+S SDS +SSES     SS+SD+ D  +            +
Sbjct: 672 SDSSDSSSSSDSSNSSDSSDS-SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSN 730

Query: 739 EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSK 798
             D    +         ++S+S + SDSS SS+ S+ +  S+      +S S  +  SS 
Sbjct: 731 SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSN 790

Query: 799 SAPAT 803
           S+ ++
Sbjct: 791 SSDSS 795



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 42/154 (27%), Positives = 64/154 (41%), Gaps = 1/154 (0%)

Query: 665 SNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQD 724
           SN  +  +      SDS   S  + S  SD +S + SDS  SS S     SS+S N    
Sbjct: 696 SNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDS 755

Query: 725 EDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQL 784
            D      S       D    +         ++S+S + SD SS+SS+S  +S+S +   
Sbjct: 756 SDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSD-SSNSSDSSNSSDSSDSSD 814

Query: 785 EPASWSRKTPPSSKSAPATKEISLLDLEDFTPPS 818
              S S  +  SS S+ ++   +  D  D +  S
Sbjct: 815 SSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS 848



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 41/137 (29%), Positives = 64/137 (46%), Gaps = 2/137 (1%)

Query: 665 SNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQD 724
           S+ +     +    SDS   S  ++S+DS   S+  SDS SS+ S S  SS  SD+ D  
Sbjct: 816 SDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDG-SDSDSSNRSDSSNSSDSSDSSDSS 874

Query: 725 EDEEKGRGSES-EQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQ 783
              +    S+S E S       +         ++S+S + SDSS+SS  SE ++ S+   
Sbjct: 875 NSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSN 934

Query: 784 LEPASWSRKTPPSSKSA 800
              +S S  +  SS S+
Sbjct: 935 SSDSSNSSDSSDSSDSS 951



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 35/122 (28%), Positives = 57/122 (46%), Gaps = 1/122 (0%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
           SDS   S  ++S+DS   S+S   S S+  S S +SS  S++ D D  +       S+ S
Sbjct: 859 SDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSS 918

Query: 739 -EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSS 797
              D    +         ++S+S + SDSS SS+ S+ ++ S+      +S S  +  S 
Sbjct: 919 NSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSD 978

Query: 798 KS 799
            S
Sbjct: 979 SS 980



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 35/104 (33%), Positives = 50/104 (48%), Gaps = 4/104 (3%)

Query: 679  SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
            SDS   S  + S+DS   S+S   S SS  S S +SS  SD+ D  +  +    S+S  S
Sbjct: 1169 SDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1228

Query: 739  EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEE 782
             +  +            ++S S   SDSS SS  S+ TS+S +E
Sbjct: 1229 SDSNESSDSSD----SSDSSDSSNSSDSSDSSDSSDSTSDSNDE 1268



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 37/122 (30%), Positives = 54/122 (44%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
           SDS   S  + S+DS   S+S   S SS+ S S +SS+ SD+ D     +    S+S  S
Sbjct: 753 SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDS 812

Query: 739 EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSK 798
            +     +           SS    S  SS SS+S   S+S+      +S S  +  SS 
Sbjct: 813 SDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSD 872

Query: 799 SA 800
           S+
Sbjct: 873 SS 874



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 45/169 (26%), Positives = 76/169 (44%), Gaps = 3/169 (1%)

Query: 679  SDSEGESGPTESADSDPESESE--SDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESE 736
            SDS   S  + S+DS   S+S   SDS  S+ S S +SS+ SD+ D  +  +    S+S 
Sbjct: 942  SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1001

Query: 737  QSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPS 796
             S  D    +         ++S+S + S+SS SS  S+ +  S+      +S S  +  S
Sbjct: 1002 NS-SDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS 1060

Query: 797  SKSAPATKEISLLDLEDFTPPSVQPVSPPAIVSTSLAADLEGLTLTDST 845
            S S+ ++      D  D +  S    S  +  S+  +   +    +DS+
Sbjct: 1061 SDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSS 1109



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 37/139 (26%), Positives = 65/139 (46%), Gaps = 4/139 (2%)

Query: 665 SNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQD 724
           S  +  K +     SDS+ +S  + S+DS   S+S   S SS+ S S +SS  SD+    
Sbjct: 622 SKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSS 681

Query: 725 EDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQL 784
           +       S+S     D    ++        ++ SSD    S+S+SS+S+ ++ S+    
Sbjct: 682 DSSNSSDSSDS----SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDS 737

Query: 785 EPASWSRKTPPSSKSAPAT 803
             +S S  +  SS S+ ++
Sbjct: 738 SNSSDSSDSSDSSNSSDSS 756



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 37/141 (26%), Positives = 65/141 (46%), Gaps = 2/141 (1%)

Query: 665 SNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQD 724
           S+ + + +      SDS   S  ++S++S   S+S   S SS  S S +SS+ SD+ D  
Sbjct: 634 SDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSS 693

Query: 725 EDEEKGRGSESEQSEEDGKRKTKKKVPERK--GEASSSDEGSDSSSSSSESEMTSESEEE 782
           +       S+S  S +     +           ++S+S + SDSS+SS  S+ +  S   
Sbjct: 694 DSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSS 753

Query: 783 QLEPASWSRKTPPSSKSAPAT 803
               +S S  +  SS S+ ++
Sbjct: 754 DSSDSSDSSNSSDSSDSSDSS 774



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 37/123 (30%), Positives = 62/123 (50%), Gaps = 4/123 (3%)

Query: 679 SDSEGESGPTESADSDPESESE--SDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESE 736
           SDS   S  ++S+DS   S+S   SDS  SS+S   +SS+ SD+ +  +  +    S+S 
Sbjct: 783 SDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSS 842

Query: 737 QSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPS 796
            S +             + ++S+S + SDSS SS+ S+ +  S+  +   +S S  +  S
Sbjct: 843 DSSDSSDGSDSDS--SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNS 900

Query: 797 SKS 799
           S S
Sbjct: 901 SDS 903



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 41/140 (29%), Positives = 65/140 (46%), Gaps = 7/140 (5%)

Query: 679 SDSEGESGPTESADSDPESESESD-----SKSSSESGSGESSSESDNEDQDEDEEKGRGS 733
           SDS   S  ++S+DS   S+S+S      S SS  S S +SS+ SD+ D  +  E    S
Sbjct: 833 SDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSS 892

Query: 734 ESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKT 793
           +S  S       +         ++S S   SDSS SS+ S+ ++ S+      +S S  +
Sbjct: 893 DSSDSSNSSDSDSSDS--SNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDS 950

Query: 794 PPSSKSAPATKEISLLDLED 813
             SS S+ ++   +  D  D
Sbjct: 951 SNSSDSSNSSDSSNSSDSSD 970



 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 36/139 (25%), Positives = 64/139 (46%), Gaps = 1/139 (0%)

Query: 665 SNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQD 724
           S+ +     +    SDS   S  ++S+DS     S+S   S+S S   +SS+ SD+ D  
Sbjct: 679 SSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSS 738

Query: 725 EDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQL 784
              +    S+S  S  D    +         ++S S + SDSS+SS  ++ ++ S+    
Sbjct: 739 NSSDSSDSSDSSNS-SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDS 797

Query: 785 EPASWSRKTPPSSKSAPAT 803
             +S S  +  SS S+ ++
Sbjct: 798 SNSSDSSNSSDSSDSSDSS 816



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 38/125 (30%), Positives = 62/125 (49%), Gaps = 3/125 (2%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
           SDS   S  ++S+DS+ ES + SDS  SS S   +SS  S++ D  +       SES  S
Sbjct: 871 SDSSNSSDSSDSSDSN-ESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNS 929

Query: 739 EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSK 798
            ++          +    + SS+  S  SS+SS+S  +S+S +     +S S  +  SS 
Sbjct: 930 SDNSNSSDSSNSSDSSDSSDSSN--SSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSD 987

Query: 799 SAPAT 803
           S+ ++
Sbjct: 988 SSDSS 992



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 37/122 (30%), Positives = 60/122 (49%), Gaps = 2/122 (1%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSE-SEQ 737
           SDS   S  ++S++S   S+S SDS  S  S S +SS+ SD+ D     +    S+ S+ 
Sbjct: 792 SDSSDSSNSSDSSNSSDSSDS-SDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDG 850

Query: 738 SEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSS 797
           S+ D   ++         ++S S   SDSS SS  +E ++ S+      +S S  +  S+
Sbjct: 851 SDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSN 910

Query: 798 KS 799
            S
Sbjct: 911 SS 912



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 37/127 (29%), Positives = 64/127 (50%), Gaps = 4/127 (3%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
           SDS   S  ++S+DS   S+S + S S+  S S +SS  S++ D     +    S+S  S
Sbjct: 759 SDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDS--S 816

Query: 739 EEDGKRKTKKKVPERKGEASSSDEGSDSSSSS--SESEMTSESEEEQLEPASWSRKTPPS 796
           + D    +         ++S+S + SDSS SS  S+S+ ++ S+      +S S  +  S
Sbjct: 817 DSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNS 876

Query: 797 SKSAPAT 803
           S S+ ++
Sbjct: 877 SDSSDSS 883



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 38/131 (29%), Positives = 60/131 (45%), Gaps = 6/131 (4%)

Query: 679  SDSEGESGPTESADSDPESESES-----DSKSSSESGSGESSSESDNEDQDEDEEKGRGS 733
            SDS   S  ++S+DS   S+S+S      S SS  S S +SS  S++ D     +    S
Sbjct: 883  SDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSS 942

Query: 734  ESEQSEEDGKRKTKKKVPERKGEASSSD-EGSDSSSSSSESEMTSESEEEQLEPASWSRK 792
            +S  S +           +    + SSD   SDSS SS+ S+ +  S+      +S S  
Sbjct: 943  DSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSN 1002

Query: 793  TPPSSKSAPAT 803
            +  SS S+ ++
Sbjct: 1003 SSDSSDSSDSS 1013



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 45/155 (29%), Positives = 66/155 (42%), Gaps = 15/155 (9%)

Query: 679 SDSEGESGPTESADSDPESE------SESDSKS-SSESGSGESSSESDNEDQDEDEEKGR 731
           SDS   S  ++S+DS  +S       S+SDSKS SS+S S +SS  SD+ D         
Sbjct: 608 SDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSD 667

Query: 732 GSESEQSEEDGKRKTKKKVPE--------RKGEASSSDEGSDSSSSSSESEMTSESEEEQ 783
            S+S  S +           +           E+S S + SDS SS S     S S +  
Sbjct: 668 SSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSD 727

Query: 784 LEPASWSRKTPPSSKSAPATKEISLLDLEDFTPPS 818
              +S S  +  SS S+ ++   +  D  D +  S
Sbjct: 728 SSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSS 762



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 40/141 (28%), Positives = 62/141 (43%), Gaps = 6/141 (4%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNED----QDEDEEKGRGSE 734
           SDS   S  ++S+DS   S S   S SS  S S +SS+ SD+ D     D  +       
Sbjct: 744 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDS 803

Query: 735 SEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSS--SSESEMTSESEEEQLEPASWSRK 792
           S  S+      +         ++S+S + SDSS+S  SS+S  +S+  +      S S  
Sbjct: 804 SNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSN 863

Query: 793 TPPSSKSAPATKEISLLDLED 813
           +  SS S+ ++      D  D
Sbjct: 864 SSDSSDSSDSSNSSDSSDSSD 884



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 44/138 (31%), Positives = 67/138 (48%), Gaps = 7/138 (5%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESD---NEDQDEDEEKGRGSES 735
           SDS   S  + S+DS   S+S SDS SS+ S S  SS  SD   + D  +  +   GS+S
Sbjct: 795 SDSSNSSDSSNSSDSSDSSDS-SDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDS 853

Query: 736 EQS-EEDGKRKTKKKVPERKGEASSSDEGSDS--SSSSSESEMTSESEEEQLEPASWSRK 792
           + S   D    +          +S S + SDS  SS+SS+S  +S S +     +S S  
Sbjct: 854 DSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSD 913

Query: 793 TPPSSKSAPATKEISLLD 810
           +  SS S+ +++  +  D
Sbjct: 914 SSDSSNSSDSSESSNSSD 931



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 41/150 (27%), Positives = 65/150 (43%), Gaps = 2/150 (1%)

Query: 665 SNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQD 724
           S+ +     +    SDS   S  + S+DS   S+S ++S +SS+S    +SS+SD+ D  
Sbjct: 851 SDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDS-NESSNSSDSSDSSNSSDSDSSDSS 909

Query: 725 EDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSS-SSESEMTSESEEEQ 783
              +    S S  S E           +    + SSD    S+SS SS S  +S S +  
Sbjct: 910 NSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 969

Query: 784 LEPASWSRKTPPSSKSAPATKEISLLDLED 813
              +S S  +  SS S+ ++      D  D
Sbjct: 970 DSNSSDSSDSSNSSDSSDSSDSSDSSDSSD 999



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 32/115 (27%), Positives = 47/115 (40%)

Query: 679  SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
            SDS   S  ++S+DS   S+S   S SS  S S +SS  SD+ D  +  E    S+S  S
Sbjct: 1184 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDS 1243

Query: 739  EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKT 793
             +           +     S S++ SDS S S          +   E +  +  T
Sbjct: 1244 SDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHST 1298



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 39/138 (28%), Positives = 58/138 (42%), Gaps = 4/138 (2%)

Query: 665 SNREKRKEKEKPFYSDSEGESGPTESADSDPESESE--SDSKSSSESGSGESSSESDNED 722
           SN     +      SDS   S  + S+DS   S S   SDS  SS+    +SS+ SD+ +
Sbjct: 804 SNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSN 863

Query: 723 QDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEE 782
             +  +    S S  S +           +    ++SSD  SDSS SS+ S+ +  S   
Sbjct: 864 SSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSD--SDSSDSSNSSDSSDSSNSS 921

Query: 783 QLEPASWSRKTPPSSKSA 800
               +S S     SS S+
Sbjct: 922 DSSESSNSSDNSNSSDSS 939



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 30/100 (30%), Positives = 45/100 (45%)

Query: 679  SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
            SDS   S  ++S+DS   S+S   S SS  + S +SS  SD+ D     +    S+S  S
Sbjct: 1202 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDS 1261

Query: 739  EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSE 778
              D   ++  +     G  + SD  SDS  S S    + +
Sbjct: 1262 TSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD 1301



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 43/148 (29%), Positives = 67/148 (45%), Gaps = 28/148 (18%)

Query: 681 SEGESGPTESADSDPESESESDSKSSSES-GSGESSSESDNE---------DQDEDEEKG 730
           S+  S   +S D D +S    D  SS ES G+ +++SESDN          + DE ++ G
Sbjct: 443 SDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNG 502

Query: 731 RGSESEQSEEDGKRKTKK------------------KVPERKGEASSSDEGSDSSSSSSE 772
            GS+S+ +E+D    T                    K    KG++ SSD  S  SS+SS+
Sbjct: 503 NGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSD 562

Query: 773 SEMTSESEEEQLEPASWSRKTPPSSKSA 800
           S  +S+S+      +S S  +   S  +
Sbjct: 563 SSDSSDSDSSDSNSSSDSDSSDSDSSDS 590



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 35/136 (25%), Positives = 63/136 (46%), Gaps = 2/136 (1%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
           S+S   S  ++S+DS   S S   + SS+ S S +SS+ SD+ +  +  +    S+S+ S
Sbjct: 762 SNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSS 821

Query: 739 -EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSS 797
              D    +         ++S S + SD S S S +   S +  +  + +S S  +  SS
Sbjct: 822 NSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSD-SSDSSNSSDSS 880

Query: 798 KSAPATKEISLLDLED 813
            S+ + +  +  D  D
Sbjct: 881 DSSDSNESSNSSDSSD 896



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 32/138 (23%), Positives = 61/138 (44%), Gaps = 4/138 (2%)

Query: 666 NREKRKEKEKPFYSDSEGESGPTESAD----SDPESESESDSKSSSESGSGESSSESDNE 721
           N +   E +    S  +      ES D    SD +   + DS S+S++ + +S+   +N 
Sbjct: 474 NDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNG 533

Query: 722 DQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEE 781
           + D D+      +S+ S+ D    +         ++ SSD  S S S SS+S+ +  S+ 
Sbjct: 534 NDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDS 593

Query: 782 EQLEPASWSRKTPPSSKS 799
           +  + ++ S  +  S  S
Sbjct: 594 DSSDSSNSSDSSDSSDSS 611



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 35/135 (25%), Positives = 62/135 (45%), Gaps = 4/135 (2%)

Query: 680 DSEGESGPTESADSDPESESESDSKSSSESGSGES-SSESDNEDQDEDEEKGRGSESEQS 738
           D    +  T ++DS+    + +D    S+SG G+S SS+SD+ D     +    S+S+ S
Sbjct: 513 DDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSS 572

Query: 739 EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSK 798
           + +    +     +    + SSD  S  SS+SS+S  +S+S +      S   K+  S  
Sbjct: 573 DSNSSSDSDSSDSD---SSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKS 629

Query: 799 SAPATKEISLLDLED 813
            + ++   S  D  D
Sbjct: 630 ESDSSDSDSKSDSSD 644



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 37/138 (26%), Positives = 60/138 (43%), Gaps = 3/138 (2%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESS--SESDNEDQDEDEEKGRGSESE 736
           S    +S  + S+DS   S+S   S SS  S S +SS  S+SD+ ++ +       S+S 
Sbjct: 812 SSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSS 871

Query: 737 QSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSE-SEEEQLEPASWSRKTPP 795
            S             E    + SSD  + S S SS+S  +S+ S+      +S S  +  
Sbjct: 872 DSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSD 931

Query: 796 SSKSAPATKEISLLDLED 813
           +S S+ ++      D  D
Sbjct: 932 NSNSSDSSNSSDSSDSSD 949



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 35/102 (34%), Positives = 49/102 (48%), Gaps = 8/102 (7%)

Query: 679  SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSES--- 735
            SDS   S  ++S+DS   S+S   S SS  S S ESS  SD+ D  +       S+S   
Sbjct: 1199 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDS 1258

Query: 736  ----EQSEEDGKRKTKKKVPERKGEASSSD-EGSDSSSSSSE 772
                  S ++   ++K       G  S SD EGSDS+ S+S+
Sbjct: 1259 SDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSD 1300



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 34/125 (27%), Positives = 64/125 (51%), Gaps = 5/125 (4%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
           S   G    ++ A+ D +S+S SD+ +S  +G+G + ++ DN+  D  + K   S+S+ S
Sbjct: 498 SKDNGNGSDSKGAEDD-DSDSTSDTNNSDSNGNGNNGND-DNDKSDSGKGKSDSSDSDSS 555

Query: 739 EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSK 798
           +      +         ++S S+  SDS SS S+S  +S+S+      +S S  +  SS 
Sbjct: 556 DSSNSSDSS---DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSD 612

Query: 799 SAPAT 803
           S+ ++
Sbjct: 613 SSDSS 617



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 28/92 (30%), Positives = 42/92 (45%)

Query: 679  SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
            S+S   S  ++S+DS   S+S   S SS  S S +SS  SD+ D  +  +    +ES  S
Sbjct: 1178 SNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDS 1237

Query: 739  EEDGKRKTKKKVPERKGEASSSDEGSDSSSSS 770
             +           +    + SSD  SDS+  S
Sbjct: 1238 SDSSDSSDSSNSSDSSDSSDSSDSTSDSNDES 1269



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 30/132 (22%), Positives = 59/132 (44%), Gaps = 3/132 (2%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGE---SSSESDNEDQDEDEEKGRGSES 735
           ++SE ++  +   D+   S+   D+ + S+S   E   S S SD  + D +     G++ 
Sbjct: 477 ANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDD 536

Query: 736 EQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPP 795
               + GK K+     +    ++SSD    S S SS+S  +S+S+    + +  S     
Sbjct: 537 NDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSS 596

Query: 796 SSKSAPATKEIS 807
            S ++  + + S
Sbjct: 597 DSSNSSDSSDSS 608



 Score = 37.7 bits (86), Expect = 0.059
 Identities = 35/144 (24%), Positives = 57/144 (39%), Gaps = 21/144 (14%)

Query: 683 GESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQ----- 737
           G     +    D E E   + K SS +  G+   +   ED D D   G+ S+S++     
Sbjct: 250 GADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKED-DHDSSIGQNSDSKEYYDPE 308

Query: 738 ------SEEDGKRKTKKK-----VPERKGEASSSD--EGSDSSSSSSESEMTSESEEEQL 784
                 +E DG + +K +     +PE  G     D  + +   S   E+ +T ESE   +
Sbjct: 309 GKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAV 368

Query: 785 EPA--SWSRKTPPSSKSAPATKEI 806
             +         PSS +   TKE+
Sbjct: 369 GKSQDKGIEIKGPSSGNRNITKEV 392



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 26/133 (19%), Positives = 54/133 (40%), Gaps = 4/133 (3%)

Query: 684 ESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGK 743
           E  P  ++  +   E+E    +  ++G   S         DEDE++G G + ++   +GK
Sbjct: 212 EITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGK 271

Query: 744 RKTKKKVPERKGEASSSDEGSDSS---SSSSESEMTSESEEEQLEPASWSRKTPPSSKSA 800
             +      ++G+    ++  DSS   +S S+     E +E+        + +     SA
Sbjct: 272 DSSNNS-KGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSA 330

Query: 801 PATKEISLLDLED 813
              ++     +ED
Sbjct: 331 GIPEDNGSQRIED 343



 Score = 33.9 bits (76), Expect = 0.85
 Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 1/83 (1%)

Query: 678 YSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQ 737
           Y D EG+  P    D D  S+SE +S    E  +G    E   +    + ++     +++
Sbjct: 304 YYDPEGKEDPHNEVDGDKTSKSEENSAGIPED-NGSQRIEDTQKLNHRESKRVENRITKE 362

Query: 738 SEEDGKRKTKKKVPERKGEASSS 760
           SE     K++ K  E KG +S +
Sbjct: 363 SETHAVGKSQDKGIEIKGPSSGN 385


>gi|221316632 coatomer protein complex, subunit beta 1 [Homo
           sapiens]
          Length = 953

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 100/549 (18%), Positives = 209/549 (38%), Gaps = 86/549 (15%)

Query: 42  LKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVA-CKNIEVKKLVYVYLVRY 100
           LK  L+      K EA+K+++ MI  G+    L   +++ V   ++  +KKL+ V+    
Sbjct: 26  LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85

Query: 101 AEEQQDLALLS-----ISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAAS 155
            +   D  LL         +++ L+ PN+ IR S LR L  ++   ++  +M AI+    
Sbjct: 86  PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145

Query: 156 DMSPYVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPER-- 213
               YVR+ A  AI  +Y              E L+ D   L+   +V   +  C     
Sbjct: 146 HRHSYVRRNAVLAIYTIY-----------RNFEHLIPDAPELIHDFLVNEKDASCKRNAF 194

Query: 214 IDLIHKNYRK----LCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAF 269
           + LIH +  +    L   +  V+ +G ++ + ++    +    +P++    +     +  
Sbjct: 195 MMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFI-----RCI 249

Query: 270 YGSEEDEAKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYF 329
           Y   +  +     E        S  P                         + A AQ Y 
Sbjct: 250 YNLLQSSSPAVKYEAAGTLVTLSSAP-----------------------TAIKAAAQCYI 286

Query: 330 HLAPKAEVGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFY-----IRS 384
            L  K               S + V+ +VL  +  + +K     E  L+        + S
Sbjct: 287 DLIIK--------------ESDNNVKLIVLDRL--IELKEHPAHERVLQDLVMDILRVLS 330

Query: 385 TDPTQIKILKLEVLTNLANETNIPTVLREFQTYI---------RSMDKDFVAATIQAIGR 435
           T   +++   L++  +L +  N+  ++   +  +            DK +    ++ +  
Sbjct: 331 TPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDK-YRQLLVRTLHS 389

Query: 436 CATNIGRVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNI 495
           C+     +    +  L++ LS+ +E   A+ +  +++ +Q        I++ + ++   I
Sbjct: 390 CSVRFPDMAANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAI 449

Query: 496 QVPMARASILWLIGEYC---EHVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTN 552
           +        LW++GEYC   E +  +  ++ R + +    E +I K +   L  +  +T 
Sbjct: 450 KSVKIYRGALWILGEYCSTKEDIQSVMTEIRRSLGEIPIVESEI-KKEAGELKPEEEITV 508

Query: 553 SKQTKLLTQ 561
               KL+T+
Sbjct: 509 GPVQKLVTE 517


>gi|221316630 coatomer protein complex, subunit beta 1 [Homo
           sapiens]
          Length = 953

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 100/549 (18%), Positives = 209/549 (38%), Gaps = 86/549 (15%)

Query: 42  LKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVA-CKNIEVKKLVYVYLVRY 100
           LK  L+      K EA+K+++ MI  G+    L   +++ V   ++  +KKL+ V+    
Sbjct: 26  LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85

Query: 101 AEEQQDLALLS-----ISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAAS 155
            +   D  LL         +++ L+ PN+ IR S LR L  ++   ++  +M AI+    
Sbjct: 86  PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145

Query: 156 DMSPYVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPER-- 213
               YVR+ A  AI  +Y              E L+ D   L+   +V   +  C     
Sbjct: 146 HRHSYVRRNAVLAIYTIY-----------RNFEHLIPDAPELIHDFLVNEKDASCKRNAF 194

Query: 214 IDLIHKNYRK----LCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAF 269
           + LIH +  +    L   +  V+ +G ++ + ++    +    +P++    +     +  
Sbjct: 195 MMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFI-----RCI 249

Query: 270 YGSEEDEAKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYF 329
           Y   +  +     E        S  P                         + A AQ Y 
Sbjct: 250 YNLLQSSSPAVKYEAAGTLVTLSSAP-----------------------TAIKAAAQCYI 286

Query: 330 HLAPKAEVGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFY-----IRS 384
            L  K               S + V+ +VL  +  + +K     E  L+        + S
Sbjct: 287 DLIIK--------------ESDNNVKLIVLDRL--IELKEHPAHERVLQDLVMDILRVLS 330

Query: 385 TDPTQIKILKLEVLTNLANETNIPTVLREFQTYI---------RSMDKDFVAATIQAIGR 435
           T   +++   L++  +L +  N+  ++   +  +            DK +    ++ +  
Sbjct: 331 TPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDK-YRQLLVRTLHS 389

Query: 436 CATNIGRVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNI 495
           C+     +    +  L++ LS+ +E   A+ +  +++ +Q        I++ + ++   I
Sbjct: 390 CSVRFPDMAANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAI 449

Query: 496 QVPMARASILWLIGEYC---EHVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTN 552
           +        LW++GEYC   E +  +  ++ R + +    E +I K +   L  +  +T 
Sbjct: 450 KSVKIYRGALWILGEYCSTKEDIQSVMTEIRRSLGEIPIVESEI-KKEAGELKPEEEITV 508

Query: 553 SKQTKLLTQ 561
               KL+T+
Sbjct: 509 GPVQKLVTE 517


>gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens]
          Length = 953

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 100/549 (18%), Positives = 209/549 (38%), Gaps = 86/549 (15%)

Query: 42  LKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVA-CKNIEVKKLVYVYLVRY 100
           LK  L+      K EA+K+++ MI  G+    L   +++ V   ++  +KKL+ V+    
Sbjct: 26  LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85

Query: 101 AEEQQDLALLS-----ISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAAS 155
            +   D  LL         +++ L+ PN+ IR S LR L  ++   ++  +M AI+    
Sbjct: 86  PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145

Query: 156 DMSPYVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPER-- 213
               YVR+ A  AI  +Y              E L+ D   L+   +V   +  C     
Sbjct: 146 HRHSYVRRNAVLAIYTIY-----------RNFEHLIPDAPELIHDFLVNEKDASCKRNAF 194

Query: 214 IDLIHKNYRK----LCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAF 269
           + LIH +  +    L   +  V+ +G ++ + ++    +    +P++    +     +  
Sbjct: 195 MMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFI-----RCI 249

Query: 270 YGSEEDEAKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYF 329
           Y   +  +     E        S  P                         + A AQ Y 
Sbjct: 250 YNLLQSSSPAVKYEAAGTLVTLSSAP-----------------------TAIKAAAQCYI 286

Query: 330 HLAPKAEVGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFY-----IRS 384
            L  K               S + V+ +VL  +  + +K     E  L+        + S
Sbjct: 287 DLIIK--------------ESDNNVKLIVLDRL--IELKEHPAHERVLQDLVMDILRVLS 330

Query: 385 TDPTQIKILKLEVLTNLANETNIPTVLREFQTYI---------RSMDKDFVAATIQAIGR 435
           T   +++   L++  +L +  N+  ++   +  +            DK +    ++ +  
Sbjct: 331 TPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDK-YRQLLVRTLHS 389

Query: 436 CATNIGRVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNI 495
           C+     +    +  L++ LS+ +E   A+ +  +++ +Q        I++ + ++   I
Sbjct: 390 CSVRFPDMAANVIPVLMEFLSDNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAI 449

Query: 496 QVPMARASILWLIGEYC---EHVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTN 552
           +        LW++GEYC   E +  +  ++ R + +    E +I K +   L  +  +T 
Sbjct: 450 KSVKIYRGALWILGEYCSTKEDIQSVMTEIRRSLGEIPIVESEI-KKEAGELKPEEEITV 508

Query: 553 SKQTKLLTQ 561
               KL+T+
Sbjct: 509 GPVQKLVTE 517


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 41/147 (27%), Positives = 64/147 (43%), Gaps = 2/147 (1%)

Query: 670  RKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDE--DE 727
            R+   +P   DS GE    ES   + ES  E +     E    +   +SD+ D+ E  DE
Sbjct: 1020 RRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDE 1079

Query: 728  EKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPA 787
            +      SE+ E D   +    +   K EA+SS E S+SS   S SE +  S E++ E  
Sbjct: 1080 DTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVV 1139

Query: 788  SWSRKTPPSSKSAPATKEISLLDLEDF 814
            +   +     +   A + ++    EDF
Sbjct: 1140 AREEEEEEEEEEMVAEESMASAGPEDF 1166



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 45/196 (22%), Positives = 76/196 (38%), Gaps = 34/196 (17%)

Query: 654  RNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGE 713
            R +E+    +   +E   E+++    + E E    E  D D +S+   +S++  E  +  
Sbjct: 1025 RPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALS 1084

Query: 714  SSSESDNEDQDEDE------EKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSS 767
             +SE D  D DE+E       K   + S +S E               E  SS E S SS
Sbjct: 1085 EASEKDEGDSDEEETVSIVTSKAEATSSSESSE-------------SSEFESSSESSPSS 1131

Query: 768  SSSSESEMTSESEEEQLEPASWSRKTPPS---------------SKSAPATKEISLLDLE 812
            S   E  +  E EEE+ E    + ++  S               +  APA   + + +  
Sbjct: 1132 SEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEV 1191

Query: 813  DFTPPSVQPVSPPAIV 828
            D    +V P   P+++
Sbjct: 1192 DIETEAVAPEERPSML 1207



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 47/182 (25%), Positives = 76/182 (41%), Gaps = 24/182 (13%)

Query: 639  QELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESE 698
            QE  +  EEA +      E  E     + + R E E      +  E+   +  DSD E  
Sbjct: 1045 QESTEEEEEAEEE-----EEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEET 1099

Query: 699  -----SESDSKSSSESGSG---ESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKV 750
                 S++++ SSSES      ESSSES +    EDEE+    E E+ EE+ +   ++ +
Sbjct: 1100 VSIVTSKAEATSSSESSESSEFESSSES-SPSSSEDEEEVVAREEEEEEEEEEMVAEESM 1158

Query: 751  P-------ERKGEASSSDEGS---DSSSSSSESEMTSESEEEQLEPASWSRKTPPSSKSA 800
                    E+ GE ++   G+   DS     E ++ +E+   +  P+       P     
Sbjct: 1159 ASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEE 1218

Query: 801  PA 802
            PA
Sbjct: 1219 PA 1220



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 26/87 (29%), Positives = 40/87 (45%), Gaps = 3/87 (3%)

Query: 702  DSKSSSESGSGESSSESDNEDQDEDEEKGRG---SESEQSEEDGKRKTKKKVPERKGEAS 758
            D+ SS +      S+  D ED++ + E+ R    +  E ++ D K    ++ P R  E  
Sbjct: 971  DTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPLELD 1030

Query: 759  SSDEGSDSSSSSSESEMTSESEEEQLE 785
            S  E  +  S S E E T E EE + E
Sbjct: 1031 SGGEEDEKESLSEEQESTEEEEEAEEE 1057



 Score = 30.8 bits (68), Expect = 7.2
 Identities = 43/202 (21%), Positives = 68/202 (33%), Gaps = 18/202 (8%)

Query: 642 PDWPEEAPDPSVRNVEVPEWTKC-------SNREKRKEKEKPFYSDSEGESGPTESADSD 694
           P+ P ++ D  +  +   + TK        S+ E + E      S S+         +S 
Sbjct: 492 PEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSPISSSSSQLSPLAPFGTNSQ 551

Query: 695 PESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGK-------RKTK 747
           P     +   S   S   E  S +   D DEDEE   G       E G         +T 
Sbjct: 552 PGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDEELDLGLGPRPPPEPGPPDPAGLLSQTA 611

Query: 748 KKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPP----SSKSAPAT 803
           +   +  G+ + + E  D    SS  +M    +E    P + +    P       +A A 
Sbjct: 612 EVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAAAVAA 671

Query: 804 KEISLLDLEDFTPPSVQPVSPP 825
             +    L    PP   P+ PP
Sbjct: 672 PSVLAPTLPLPPPPGFPPLPPP 693


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 60/205 (29%), Positives = 93/205 (45%), Gaps = 38/205 (18%)

Query: 644 WPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDS 703
           W    P P     E+ +  K    EK +E++                  SD +  S+S+ 
Sbjct: 219 WSRSPPRPPRERFELGDGRKPVKEEKMEERDLL----------------SDLQDISDSER 262

Query: 704 KSSS-ESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDE 762
           K+SS ES S ES S S+ E+++E+EE+  GS SE+SEE+ + + +    E +   S+S+E
Sbjct: 263 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE----EEEETGSNSEE 318

Query: 763 GSDSSSSSSESEMTSESEEEQLE----PASWSRKTPPSSKSAPATKEI-------SLLDL 811
            S+ S+     E  SE EE + E        SR    S +S  A +E+       S L  
Sbjct: 319 ASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 378

Query: 812 EDFTPPSVQPVSPPAIVSTSLAADL 836
            D+ P S      PA++   L  +L
Sbjct: 379 GDYVPDS------PALLPIELKQEL 397


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 60/205 (29%), Positives = 93/205 (45%), Gaps = 38/205 (18%)

Query: 644 WPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDS 703
           W    P P     E+ +  K    EK +E++                  SD +  S+S+ 
Sbjct: 229 WSRSPPRPPRERFELGDGRKPVKEEKMEERDLL----------------SDLQDISDSER 272

Query: 704 KSSS-ESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDE 762
           K+SS ES S ES S S+ E+++E+EE+  GS SE+SEE+ + + +    E +   S+S+E
Sbjct: 273 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE----EEEETGSNSEE 328

Query: 763 GSDSSSSSSESEMTSESEEEQLE----PASWSRKTPPSSKSAPATKEI-------SLLDL 811
            S+ S+     E  SE EE + E        SR    S +S  A +E+       S L  
Sbjct: 329 ASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 388

Query: 812 EDFTPPSVQPVSPPAIVSTSLAADL 836
            D+ P S      PA++   L  +L
Sbjct: 389 GDYVPDS------PALLPIELKQEL 407


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 57/193 (29%), Positives = 90/193 (46%), Gaps = 34/193 (17%)

Query: 644 WPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDS 703
           W    P P     E+ +  K    EK +E++                  SD +  S+S+ 
Sbjct: 220 WSRSPPRPPRERFELGDGRKPVKEEKMEERDLL----------------SDLQDISDSER 263

Query: 704 KSSS-ESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDE 762
           K+SS ES S ES S S+ E+++E+EE+  GS SE+SEE+ + + +    E +   S+S+E
Sbjct: 264 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE----EEEETGSNSEE 319

Query: 763 GSDSSSSSSESEMTSESEEEQLE----PASWSRKTPPSSKSAPATKEI-------SLLDL 811
            S+ S+     E  SE EE + E        SR    S +S  A +E+       S L  
Sbjct: 320 ASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 379

Query: 812 EDFTP--PSVQPV 822
            D+ P  P++ P+
Sbjct: 380 GDYVPDSPALSPI 392


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 57/193 (29%), Positives = 90/193 (46%), Gaps = 34/193 (17%)

Query: 644 WPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDS 703
           W    P P     E+ +  K    EK +E++                  SD +  S+S+ 
Sbjct: 229 WSRSPPRPPRERFELGDGRKPVKEEKMEERDLL----------------SDLQDISDSER 272

Query: 704 KSSS-ESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDE 762
           K+SS ES S ES S S+ E+++E+EE+  GS SE+SEE+ + + +    E +   S+S+E
Sbjct: 273 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE----EEEETGSNSEE 328

Query: 763 GSDSSSSSSESEMTSESEEEQLE----PASWSRKTPPSSKSAPATKEI-------SLLDL 811
            S+ S+     E  SE EE + E        SR    S +S  A +E+       S L  
Sbjct: 329 ASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 388

Query: 812 EDFTP--PSVQPV 822
            D+ P  P++ P+
Sbjct: 389 GDYVPDSPALSPI 401



 Score = 34.3 bits (77), Expect = 0.65
 Identities = 41/207 (19%), Positives = 70/207 (33%), Gaps = 47/207 (22%)

Query: 660 EWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESD 719
           EW     R+KR+E  +       G  G     D   + E + + +        E   + +
Sbjct: 136 EW----ERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQREQKE 191

Query: 720 NEDQDEDEEKGRGSESEQSEE--------------------------------DGKRKTK 747
            E + E+  K R +  E S                                  DG++  K
Sbjct: 192 RERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVK 251

Query: 748 KKVPERK-----------GEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPS 796
           ++  E +            E  +S   S S+ S S SE   E EEE+ E  S S ++   
Sbjct: 252 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE 311

Query: 797 SKSAPATKEISLLDLEDFTPPSVQPVS 823
            +     +E +  + E+ +  S + VS
Sbjct: 312 EEEEEEEEEETGSNSEEASEQSAEEVS 338


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 57/193 (29%), Positives = 90/193 (46%), Gaps = 34/193 (17%)

Query: 644 WPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDS 703
           W    P P     E+ +  K    EK +E++                  SD +  S+S+ 
Sbjct: 197 WSRSPPRPPRERFELGDGRKPVKEEKMEERDLL----------------SDLQDISDSER 240

Query: 704 KSSS-ESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDE 762
           K+SS ES S ES S S+ E+++E+EE+  GS SE+SEE+ + + +    E +   S+S+E
Sbjct: 241 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE----EEEETGSNSEE 296

Query: 763 GSDSSSSSSESEMTSESEEEQLE----PASWSRKTPPSSKSAPATKEI-------SLLDL 811
            S+ S+     E  SE EE + E        SR    S +S  A +E+       S L  
Sbjct: 297 ASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 356

Query: 812 EDFTP--PSVQPV 822
            D+ P  P++ P+
Sbjct: 357 GDYVPDSPALSPI 369


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 57/193 (29%), Positives = 90/193 (46%), Gaps = 34/193 (17%)

Query: 644 WPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDS 703
           W    P P     E+ +  K    EK +E++                  SD +  S+S+ 
Sbjct: 186 WSRSPPRPPRERFELGDGRKPVKEEKMEERDLL----------------SDLQDISDSER 229

Query: 704 KSSS-ESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDE 762
           K+SS ES S ES S S+ E+++E+EE+  GS SE+SEE+ + + +    E +   S+S+E
Sbjct: 230 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE----EEEETGSNSEE 285

Query: 763 GSDSSSSSSESEMTSESEEEQLE----PASWSRKTPPSSKSAPATKEI-------SLLDL 811
            S+ S+     E  SE EE + E        SR    S +S  A +E+       S L  
Sbjct: 286 ASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 345

Query: 812 EDFTP--PSVQPV 822
            D+ P  P++ P+
Sbjct: 346 GDYVPDSPALSPI 358


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 57/193 (29%), Positives = 90/193 (46%), Gaps = 34/193 (17%)

Query: 644 WPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDS 703
           W    P P     E+ +  K    EK +E++                  SD +  S+S+ 
Sbjct: 231 WSRSPPRPPRERFELGDGRKPVKEEKMEERDLL----------------SDLQDISDSER 274

Query: 704 KSSS-ESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDE 762
           K+SS ES S ES S S+ E+++E+EE+  GS SE+SEE+ + + +    E +   S+S+E
Sbjct: 275 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE----EEEETGSNSEE 330

Query: 763 GSDSSSSSSESEMTSESEEEQLE----PASWSRKTPPSSKSAPATKEI-------SLLDL 811
            S+ S+     E  SE EE + E        SR    S +S  A +E+       S L  
Sbjct: 331 ASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 390

Query: 812 EDFTP--PSVQPV 822
            D+ P  P++ P+
Sbjct: 391 GDYVPDSPALSPI 403


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 49/144 (34%), Positives = 77/144 (53%), Gaps = 18/144 (12%)

Query: 693 SDPESESESDSKSSS-ESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVP 751
           SD +  S+S+ K+SS ES S ES S S+ E+++E+EE+  GS SE+SEE+ + + +    
Sbjct: 8   SDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE---- 63

Query: 752 ERKGEASSSDEGSDSSSSSSESEMTSESEEEQLE----PASWSRKTPPSSKSAPATKEI- 806
           E +   S+S+E S+ S+     E  SE EE + E        SR    S +S  A +E+ 
Sbjct: 64  EEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVG 123

Query: 807 ------SLLDLEDFTP--PSVQPV 822
                 S L   D+ P  P++ P+
Sbjct: 124 EGTPQSSALTEGDYVPDSPALSPI 147



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 43/160 (26%), Positives = 74/160 (46%), Gaps = 28/160 (17%)

Query: 679 SDSEGESGPTESADSDP----ESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSE 734
           SDSE ++   ES+ ++     E E E + +   E  + E S E + E+++E+EE G  SE
Sbjct: 14  SDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSE 73

Query: 735 --SEQS---------EEDGKRKTKKK---VPERK-----GEASSSDE--GSDSSSSSSES 773
             SEQS          ED +R+ +     VPE +     GE+  ++E  G  +  SS+ +
Sbjct: 74  EASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALT 133

Query: 774 EMTSESEEEQLEPASWSRKTP---PSSKSAPATKEISLLD 810
           E     +   L P    ++ P   P+ +   + +E   L+
Sbjct: 134 EGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLN 173



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 33/130 (25%), Positives = 62/130 (47%), Gaps = 11/130 (8%)

Query: 665 SNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQD 724
           S  E+ +E+E+    + EG +      + + E E E ++ S+SE  S +S+ E   E+  
Sbjct: 34  SEEEEEEEEEE----EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 89

Query: 725 EDEEKGRGS------ESEQSEEDGK-RKTKKKVPERKGEASSSDEGSDSSSSSSESEMTS 777
           EDEE+   +      ES    + G+  + +++V E   ++S+  EG     S + S +  
Sbjct: 90  EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL 149

Query: 778 ESEEEQLEPA 787
           + E  +  PA
Sbjct: 150 KQELPKYLPA 159


>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
          Length = 2968

 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 50/184 (27%), Positives = 75/184 (40%), Gaps = 9/184 (4%)

Query: 661  WTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDN 720
            W K ++ +  +E       +  G     + A ++ +   ES+S SSS SGS  SSS S +
Sbjct: 2517 WPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSS 2576

Query: 721  --------EDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSE 772
                    E+ D++ + G G+          R            +SSS   S SSSSSS 
Sbjct: 2577 SGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSS 2636

Query: 773  SEMTSESEEEQLEPASWSRKTPPSSKSAPATKEISLLDLEDFTPPSVQPVSPPAIVSTSL 832
            S  +S S       +S S  +  SS S+ ++   S  D ED +  S    +P      S 
Sbjct: 2637 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTD-EDSSCSSDDEAAPAPTAGPSA 2695

Query: 833  AADL 836
             A L
Sbjct: 2696 QAAL 2699



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 42/182 (23%), Positives = 68/182 (37%), Gaps = 21/182 (11%)

Query: 665  SNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSG------------ 712
            + ++  +E E    S S   S  + S+ S  E+E E +   + + G G            
Sbjct: 2549 AEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSR 2608

Query: 713  -----ESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSS 767
                  SSS S +            S S  S       +          +SSS   S SS
Sbjct: 2609 AASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2668

Query: 768  SSSSESEMTSESEEEQLEPASWSRKTPPSSKSAPATKEISLLDLEDFTP----PSVQPVS 823
            SSS+  E +S S +++  PA  +  +  ++    ATK+         +P    P+ QP +
Sbjct: 2669 SSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQA 2728

Query: 824  PP 825
            PP
Sbjct: 2729 PP 2730



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 34/148 (22%), Positives = 53/148 (35%), Gaps = 13/148 (8%)

Query: 679  SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQS 738
            S +   +  + S+ S   S S S S SSS S S  SSS S +            S S  S
Sbjct: 2607 SRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2666

Query: 739  EEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSK 798
                    +        EA+ +     S+ ++  ++ T ++ + +    S  +KTP    
Sbjct: 2667 SSSSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQP 2726

Query: 799  SAPATKEISLLDLEDFTPPSVQPVSPPA 826
             AP              P   QP+ P A
Sbjct: 2727 QAP-------------PPQPTQPLQPKA 2741



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 33/153 (21%), Positives = 56/153 (36%), Gaps = 4/153 (2%)

Query: 659  PEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSES 718
            P  +  S+            S S   S  + S+ S   S S S S SSS S S  SSS S
Sbjct: 2612 PASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2671

Query: 719  DNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSE 778
              ++          + +  +    +     K  ++ G+A  S       + + + +    
Sbjct: 2672 TTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPP 2731

Query: 779  SEEEQLEP-ASWSRKTPPSSKSA---PATKEIS 807
               + L+P A    K+ P  +     P TKE++
Sbjct: 2732 QPTQPLQPKAQAGAKSRPKKREGVHLPTTKELA 2764



 Score = 31.2 bits (69), Expect = 5.5
 Identities = 40/149 (26%), Positives = 56/149 (37%), Gaps = 19/149 (12%)

Query: 671  KEKEKPFYSDSEGESGPTESADS--------DPESESES-DSKSSSESGSGESSSESDNE 721
            K K+K   SD E  +   + A S         P   S+S   KS +  G G   +  D+ 
Sbjct: 1613 KIKKKKMASDQEQLASKLDKALSLTKQDKLKSPFKFSDSAGGKSKTSGGCGRYLTPYDSL 1672

Query: 722  DQDEDEEKGRG-SESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSS-------SES 773
                 +   +G   S +S  +GK K   K   RK E      G   S+ S       S S
Sbjct: 1673 LGKNRKALAKGLGLSLKSSREGKHKRAAKT--RKMEVGFKARGQPKSAHSPFASEVSSYS 1730

Query: 774  EMTSESEEEQLEPASWSRKTPPSSKSAPA 802
              T   E+E+     W  + P SSK  P+
Sbjct: 1731 YNTDSEEDEEFLKDEWPAQGPSSSKLTPS 1759


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 35/119 (29%), Positives = 57/119 (47%), Gaps = 5/119 (4%)

Query: 671 KEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKG 730
           +E+E     + EGE G  E  + + E E E + +   E G G+   E +  + + +EE+G
Sbjct: 879 EEEEGEGEGEEEGE-GEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEG 937

Query: 731 RGS----ESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLE 785
            G     E E  EE+G+ + +++  E +GE     EG +      E E   E EEE+ E
Sbjct: 938 EGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE 996



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 30/106 (28%), Positives = 48/106 (45%), Gaps = 3/106 (2%)

Query: 680  DSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSE 739
            + E E G  E  + + E E E + +   E G GE   E    + +E+E +  G E  + E
Sbjct: 947  EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE 1006

Query: 740  EDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLE 785
            E+G+ + ++   E +GE     EG +      E E   E EE + E
Sbjct: 1007 EEGEGEGEE---EEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKE 1049



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 36/120 (30%), Positives = 54/120 (45%), Gaps = 5/120 (4%)

Query: 663 KCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNED 722
           K   R  ++EK +      EGE   TE    + E   E +     E G GE   E +  +
Sbjct: 776 KKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEG-GEVEEGKGEREEEEEEGE 834

Query: 723 QDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEE 782
            +E+E +G   E E  EE+G+ K +++  E +GE    +EG +      E E   E EEE
Sbjct: 835 GEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGE----EEGEEGEGEGEEEEGEGEGEEE 890



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 9/125 (7%)

Query: 668 EKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSES------DNE 721
           E+ +E+E+    + EGE G  E  + + E E E   +   E G GE   E       + E
Sbjct: 825 EREEEEEEGEGEEEEGE-GEEEEGEGE-EEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEE 882

Query: 722 DQDEDEEKGRG-SESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESE 780
            + E EE+G G  E E+ E +G+ + + +  E +GE    +EG +      E E   E E
Sbjct: 883 GEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGE 942

Query: 781 EEQLE 785
           + + E
Sbjct: 943 DGEGE 947



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 39/118 (33%), Positives = 54/118 (45%), Gaps = 7/118 (5%)

Query: 671 KEKEKPFYSDSEGESGP--TESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEE 728
           +E+E     + EGE G    E  + + E E E       E G GE   E   E + E EE
Sbjct: 850 EEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE---EGEGEGEE 906

Query: 729 KGRGSESEQSEEDGKRKTKKKVPERKGEASSSD-EGSDSSSSSSESEMTSESEEEQLE 785
           +G G E E+ E +GK + + +  E +GE    + EG D      E E   E EEE+ E
Sbjct: 907 EGEG-EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGE 963



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 35/133 (26%), Positives = 56/133 (42%), Gaps = 9/133 (6%)

Query: 657  EVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDS--KSSSESGSGES 714
            E  EW      E+  E E     + EGE G  E  + + E E E +   +   E G GE 
Sbjct: 951  EEGEW---EGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEE 1007

Query: 715  SSESDNEDQD----EDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSS 770
              E + E+++    E E +G   E E  EE+G+ + +++  E +GE +  +   +     
Sbjct: 1008 EGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEG 1067

Query: 771  SESEMTSESEEEQ 783
               E   E  E Q
Sbjct: 1068 KYQETGEEENERQ 1080



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 37/152 (24%), Positives = 59/152 (38%), Gaps = 3/152 (1%)

Query: 637 GYQELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPE 696
           G +E      E  +   R  E  E  +    E  + K +    + EGE    E    + E
Sbjct: 787 GEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEE 846

Query: 697 ---SESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPER 753
               E E + K   E   GE   E +  + + +EE+G G   E+ E +G+ +  +   E 
Sbjct: 847 GEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEE 906

Query: 754 KGEASSSDEGSDSSSSSSESEMTSESEEEQLE 785
           +GE    +E  +        E   E EEE+ E
Sbjct: 907 EGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGE 938



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 35/120 (29%), Positives = 55/120 (45%), Gaps = 6/120 (5%)

Query: 671  KEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGE---SSSESDNEDQDEDE 727
            +E+E     + EGE G  E  + + E E E D +   E   GE      E + E ++E E
Sbjct: 913  EEEEGEGKGEEEGEEGEGEGEEEEGEGEGE-DGEGEGEEEEGEWEGEEEEGEGEGEEEGE 971

Query: 728  EKGRGSESEQSEEDGKRKTKKKVPERKG--EASSSDEGSDSSSSSSESEMTSESEEEQLE 785
             +G   E E  EE+G+ + +++  E +G  E    +EG        E E+  E E E+ E
Sbjct: 972  GEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGE 1031



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 40/158 (25%), Positives = 62/158 (39%), Gaps = 29/158 (18%)

Query: 657 EVPEWTKCSNREK---------RKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSS 707
           E  EW K    E+         +KE+ +      E E G  E  + D E E E + +   
Sbjct: 698 EKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKE 757

Query: 708 ESGSGESSSESDNED-----------QDEDEEKGRGSESEQSEEDGKRKTKK-------- 748
           E    E   E + E+           +++ EE+G   E E+ E +G+ + K+        
Sbjct: 758 EGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGG 817

Query: 749 KVPERKGEASSSDEGSDSSSSSSE-SEMTSESEEEQLE 785
           +V E KGE    +E  +      E  E   E EEE+ E
Sbjct: 818 EVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGE 855



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 35/123 (28%), Positives = 55/123 (44%), Gaps = 9/123 (7%)

Query: 668  EKRKEKEKPFYSDSEGE------SGPTESADSDPESESESDSKSSSESGSGESSSESDNE 721
            E+  E E     + EGE       G  E  + + E E E + +   E G GE   E    
Sbjct: 897  EEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGE-EEEGEGEGEDGEGEGEEEEGEW 955

Query: 722  DQDEDEEKGRGSESEQSE-EDGKRKTKKKVPERKG-EASSSDEGSDSSSSSSESEMTSES 779
            + +E+E +G G E  + E E+G+ + +++  E +G E    +EG +      E E   E 
Sbjct: 956  EGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEE 1015

Query: 780  EEE 782
            EEE
Sbjct: 1016 EEE 1018



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 38/126 (30%), Positives = 59/126 (46%), Gaps = 17/126 (13%)

Query: 666 NREKRKEKEKPFYSDSEG-ESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQD 724
           +RE+ +EKE       EG E G  E  + + E E E + K    +G  E   E  ++ + 
Sbjct: 744 DREEEEEKE------GEGKEEGEGEEVEGEREKE-EGERKKEERAGKEEKGEEEGDQGEG 796

Query: 725 EDEE-KGRGSESEQ-------SEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMT 776
           E+EE +GRG E E+         E+GK + +++  E +GE     EG +      E E  
Sbjct: 797 EEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGE-EEEGEGEEEEGEGEEEEGE 855

Query: 777 SESEEE 782
            + EEE
Sbjct: 856 GKGEEE 861



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 31/119 (26%), Positives = 51/119 (42%), Gaps = 7/119 (5%)

Query: 668 EKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDE 727
           E  ++KE+    + +GE    +    + E+E   + K       G    E   E ++E+E
Sbjct: 772 EGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEE 831

Query: 728 E-KGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLE 785
           E +G   E E  EE+G+ +      E +GE    +EG +        E   E EEE+ E
Sbjct: 832 EGEGEEEEGEGEEEEGEGE------EEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGE 884



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 48/207 (23%), Positives = 75/207 (36%), Gaps = 34/207 (16%)

Query: 590 EQGGALSRHAKKLFLAPKPAPVLESSFKDRDHFQLGSLSHLLNAKATGYQELPDWPEEAP 649
           ++G A  +H  +     +PA  +E+ F D +                   E+P+  E A 
Sbjct: 554 KEGKACKQHVSQGIFMTQPATTIEA-FSDEE------------------VEIPEEKEGAE 594

Query: 650 DPSVRNVEVPEWTKCSNREK----RKEKEKPFYSD-------SEGESGPTESADSDPESE 698
           D     +E  E        K    RKEK +    D       SEG++     A+  PE  
Sbjct: 595 DSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGR 654

Query: 699 SESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEAS 758
            +     + E GS  +    D E +  +++KGRG      E + +   K++  +R GE  
Sbjct: 655 GDG----TCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQ 710

Query: 759 SSDEGSDSSSSSSESEMTSESEEEQLE 785
              E           EM    EEE  E
Sbjct: 711 EQKEREQGHQKERNQEMEEGGEEEHGE 737



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 38/151 (25%), Positives = 62/151 (41%), Gaps = 21/151 (13%)

Query: 644 WPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDS 703
           W +E  +   ++    E  +    EK    EK  +   +GE    E    + E   + + 
Sbjct: 669 WQDEEREKGEKDKGRGEMERPGEGEKELA-EKEEWKKRDGE----EQEQKEREQGHQKER 723

Query: 704 KSSSESGSGESSSESDNEDQD-EDEEKGRGS----------ESEQSEEDGKRKTKKKV-P 751
               E G  E   E + E+ D E+EE+  G           E E+ +E+G+RK +++   
Sbjct: 724 NQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGK 783

Query: 752 ERKGEASSSDEGSDSSSSSSESEMTSESEEE 782
           E KGE    +EG        E+E   E +EE
Sbjct: 784 EEKGE----EEGDQGEGEEEETEGRGEEKEE 810



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 32/155 (20%), Positives = 56/155 (36%), Gaps = 10/155 (6%)

Query: 634 KATGYQELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGE-----SGPT 688
           KA    E  D PE   D +       E +  +   + +E+EK       GE      G  
Sbjct: 640 KAKSVGEAEDGPEGRGDGTCE-----EGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEK 694

Query: 689 ESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKK 748
           E A+ +   + + + +   E   G     +   ++  +EE G G E E   E+ + K  +
Sbjct: 695 ELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGE 754

Query: 749 KVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQ 783
              E +GE    +   +      E     E + E+
Sbjct: 755 GKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEE 789



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 29/120 (24%), Positives = 50/120 (41%), Gaps = 12/120 (10%)

Query: 668  EKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDE 727
            E  +E+E     + EGE G  E  + + E E E   K       GE      N +++E+E
Sbjct: 1012 EGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKE------GEGEENRRNREEEEEE 1065

Query: 728  EKGRGSESEQSEEDGKR---KTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQL 784
            E   G   E  EE+ +R   +  KKV + KG        +    S + ++   + +  ++
Sbjct: 1066 E---GKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKM 1122


>gi|115529449 upstream binding transcription factor, RNA polymerase
           I isoform b [Homo sapiens]
          Length = 727

 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 34/101 (33%), Positives = 49/101 (48%), Gaps = 2/101 (1%)

Query: 671 KEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKG 730
           K       S SE E    E  D + E E E D ++   S  G  SSES +ED+ ED ++ 
Sbjct: 628 KSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDE- 686

Query: 731 RGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSS 771
              E ++ E+D +   + +  E +G +SSS    DSS S S
Sbjct: 687 -NEEDDEDEDDDEDDDEDEDNESEGSSSSSSSSGDSSDSDS 726



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 35/135 (25%), Positives = 57/135 (42%), Gaps = 11/135 (8%)

Query: 656 VEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESS 715
           V +  W K  + + R   ++  Y  ++ +S       +   S +   SKS SE    E  
Sbjct: 591 VHLDLWVKSLSPQDRAAYKE--YISNKRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDE 648

Query: 716 SESDNEDQDEDEEKGRGSE---------SEQSEEDGKRKTKKKVPERKGEASSSDEGSDS 766
            + D ++++ED+E G  SE         SE   EDG    +    E   E    DE ++S
Sbjct: 649 DDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNES 708

Query: 767 SSSSSESEMTSESEE 781
             SSS S  + +S +
Sbjct: 709 EGSSSSSSSSGDSSD 723



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 14/113 (12%)

Query: 688 TESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTK 747
           T+    +P+S S +  +S SES   E   E D +D+DEDEE+      + SE+ G     
Sbjct: 620 TKLRGPNPKS-SRTTLQSKSES---EEDDEEDEDDEDEDEEEEDDENGDSSEDGGD---- 671

Query: 748 KKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSKSA 800
                   E+SS DE  D   +  + E   + E++  +  + S  +  SS S+
Sbjct: 672 ------SSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSSS 718



 Score = 34.3 bits (77), Expect = 0.65
 Identities = 19/78 (24%), Positives = 35/78 (44%)

Query: 643 DWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESD 702
           D  E+  +    N +  E    S+    +++ +    + E +    +  D D + ++ES+
Sbjct: 650 DEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESE 709

Query: 703 SKSSSESGSGESSSESDN 720
             SSS S SG+SS    N
Sbjct: 710 GSSSSSSSSGDSSDSDSN 727


>gi|115529451 upstream binding transcription factor, RNA polymerase
           I isoform b [Homo sapiens]
          Length = 727

 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 34/101 (33%), Positives = 49/101 (48%), Gaps = 2/101 (1%)

Query: 671 KEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKG 730
           K       S SE E    E  D + E E E D ++   S  G  SSES +ED+ ED ++ 
Sbjct: 628 KSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDE- 686

Query: 731 RGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSS 771
              E ++ E+D +   + +  E +G +SSS    DSS S S
Sbjct: 687 -NEEDDEDEDDDEDDDEDEDNESEGSSSSSSSSGDSSDSDS 726



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 35/135 (25%), Positives = 57/135 (42%), Gaps = 11/135 (8%)

Query: 656 VEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESS 715
           V +  W K  + + R   ++  Y  ++ +S       +   S +   SKS SE    E  
Sbjct: 591 VHLDLWVKSLSPQDRAAYKE--YISNKRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDE 648

Query: 716 SESDNEDQDEDEEKGRGSE---------SEQSEEDGKRKTKKKVPERKGEASSSDEGSDS 766
            + D ++++ED+E G  SE         SE   EDG    +    E   E    DE ++S
Sbjct: 649 DDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNES 708

Query: 767 SSSSSESEMTSESEE 781
             SSS S  + +S +
Sbjct: 709 EGSSSSSSSSGDSSD 723



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 14/113 (12%)

Query: 688 TESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTK 747
           T+    +P+S S +  +S SES   E   E D +D+DEDEE+      + SE+ G     
Sbjct: 620 TKLRGPNPKS-SRTTLQSKSES---EEDDEEDEDDEDEDEEEEDDENGDSSEDGGD---- 671

Query: 748 KKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSKSA 800
                   E+SS DE  D   +  + E   + E++  +  + S  +  SS S+
Sbjct: 672 ------SSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSSS 718



 Score = 34.3 bits (77), Expect = 0.65
 Identities = 19/78 (24%), Positives = 35/78 (44%)

Query: 643 DWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESD 702
           D  E+  +    N +  E    S+    +++ +    + E +    +  D D + ++ES+
Sbjct: 650 DEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESE 709

Query: 703 SKSSSESGSGESSSESDN 720
             SSS S SG+SS    N
Sbjct: 710 GSSSSSSSSGDSSDSDSN 727


>gi|7657671 upstream binding transcription factor, RNA polymerase I
           isoform a [Homo sapiens]
          Length = 764

 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 34/101 (33%), Positives = 49/101 (48%), Gaps = 2/101 (1%)

Query: 671 KEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKG 730
           K       S SE E    E  D + E E E D ++   S  G  SSES +ED+ ED ++ 
Sbjct: 665 KSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDE- 723

Query: 731 RGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSS 771
              E ++ E+D +   + +  E +G +SSS    DSS S S
Sbjct: 724 -NEEDDEDEDDDEDDDEDEDNESEGSSSSSSSSGDSSDSDS 763



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 35/135 (25%), Positives = 57/135 (42%), Gaps = 11/135 (8%)

Query: 656 VEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESS 715
           V +  W K  + + R   ++  Y  ++ +S       +   S +   SKS SE    E  
Sbjct: 628 VHLDLWVKSLSPQDRAAYKE--YISNKRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDE 685

Query: 716 SESDNEDQDEDEEKGRGSE---------SEQSEEDGKRKTKKKVPERKGEASSSDEGSDS 766
            + D ++++ED+E G  SE         SE   EDG    +    E   E    DE ++S
Sbjct: 686 DDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNES 745

Query: 767 SSSSSESEMTSESEE 781
             SSS S  + +S +
Sbjct: 746 EGSSSSSSSSGDSSD 760



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 14/113 (12%)

Query: 688 TESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTK 747
           T+    +P+S S +  +S SES   E   E D +D+DEDEE+      + SE+ G     
Sbjct: 657 TKLRGPNPKS-SRTTLQSKSES---EEDDEEDEDDEDEDEEEEDDENGDSSEDGGD---- 708

Query: 748 KKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSKSA 800
                   E+SS DE  D   +  + E   + E++  +  + S  +  SS S+
Sbjct: 709 ------SSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSSS 755



 Score = 34.3 bits (77), Expect = 0.65
 Identities = 19/78 (24%), Positives = 35/78 (44%)

Query: 643 DWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESD 702
           D  E+  +    N +  E    S+    +++ +    + E +    +  D D + ++ES+
Sbjct: 687 DEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESE 746

Query: 703 SKSSSESGSGESSSESDN 720
             SSS S SG+SS    N
Sbjct: 747 GSSSSSSSSGDSSDSDSN 764


>gi|217330641 IWS1 homolog [Homo sapiens]
          Length = 819

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 55/187 (29%), Positives = 86/187 (45%), Gaps = 28/187 (14%)

Query: 646 EEAPDPSVRNVEV--PEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESE----- 698
           EE P P + + E   P   + S+ E  +E  KP  SDSE E GP +   SD E+E     
Sbjct: 266 EELPKPRISDSESEDPPRNQASDSEN-EELPKPRVSDSESE-GPQKGPASDSETEDASRH 323

Query: 699 -----SESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQ---------SEEDGKR 744
                S+ DS   ++    E  ++S + D   D +K   S+SE+         S+ED K 
Sbjct: 324 KQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKE 383

Query: 745 KTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPAS----WSRKTPPSSKSA 800
             ++KV +RK  A  SD   +  +S+ +S + S++++   +  S       KT  S    
Sbjct: 384 GEEEKVAKRKA-AVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEE 442

Query: 801 PATKEIS 807
            A KE+S
Sbjct: 443 EAGKELS 449



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 37/135 (27%), Positives = 60/135 (44%), Gaps = 1/135 (0%)

Query: 646 EEAPDPSVRNVEVPEWTKCSNREKRKEK-EKPFYSDSEGESGPTESADSDPESESESDSK 704
           EE P P V + E  E  +    +   E+  KP  SDSE E  P   A      E      
Sbjct: 214 EELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRI 273

Query: 705 SSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGS 764
           S SES     +  SD+E+++  + +   SESE  ++     ++ +   R  +   SD+ S
Sbjct: 274 SDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDS 333

Query: 765 DSSSSSSESEMTSES 779
           D  +   ++EM ++S
Sbjct: 334 DRENKGEDTEMQNDS 348



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 56/195 (28%), Positives = 78/195 (40%), Gaps = 22/195 (11%)

Query: 646 EEAPDPSVRNVEV--PEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDS 703
           EE P P + + E   P   + S+ E  +E  KP  SDSE E  P   A      E     
Sbjct: 240 EELPKPRISDSESEDPPRHQASDSEN-EELPKPRISDSESEDPPRNQASDSENEELPKPR 298

Query: 704 KSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEG 763
            S SES   +    SD+E +D    K    +  +S++D  R+ K +  E + ++  SD  
Sbjct: 299 VSDSESEGPQKGPASDSETEDASRHK----QKPESDDDSDRENKGEDTEMQNDSFHSDSH 354

Query: 764 SDSS---SSSSESEM-------TSESEEEQLEPASWSRKTPPSSKS-----APATKEISL 808
            D     SS SE E        + E E+E  E     RK    S S     A A K   +
Sbjct: 355 MDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVV 414

Query: 809 LDLEDFTPPSVQPVS 823
            D +D    +V   S
Sbjct: 415 SDADDSDSDAVSDKS 429



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 51/216 (23%), Positives = 86/216 (39%), Gaps = 35/216 (16%)

Query: 632 NAKATGYQELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKE----KEKPFYSDSEGESGP 687
           ++++ G Q+ P    E  D S R+ + PE    S+RE + E    +   F+SDS  +   
Sbjct: 301 DSESEGPQKGPASDSETEDAS-RHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKK 359

Query: 688 TESADSDPESESESDSKSSSESGSGESSSE--------SDNEDQDEDEEKGRGSESEQSE 739
             S+DS+ E   +    S  +   GE            SD+ED+++   K     S+  +
Sbjct: 360 FHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADD 419

Query: 740 EDGKRKTKKKVPERKGEASSSDE-----------------GSDSSSSSSESEMTSE---- 778
            D    + K     K  AS S+E                 GSDS S + E  + ++    
Sbjct: 420 SDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGE 479

Query: 779 -SEEEQLEPASWSRKTPPSSKSAPATKEISLLDLED 813
             +EE+ E   ++++     K     KE    D +D
Sbjct: 480 SGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDD 515



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 40/154 (25%), Positives = 58/154 (37%), Gaps = 7/154 (4%)

Query: 657 EVPEWTKCSNREKRKEKE-KPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESS 715
           E+ E  K    +   E   KP  SDSE E  P   A      E      S SES      
Sbjct: 160 EIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKP 219

Query: 716 SESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEG------SDSSSS 769
             SD+E ++    +   SE+E+  +     ++ + P R   + S +E       SDS S 
Sbjct: 220 QVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESE 279

Query: 770 SSESEMTSESEEEQLEPASWSRKTPPSSKSAPAT 803
                  S+SE E+L     S       +  PA+
Sbjct: 280 DPPRNQASDSENEELPKPRVSDSESEGPQKGPAS 313



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 42/188 (22%), Positives = 77/188 (40%), Gaps = 13/188 (6%)

Query: 646 EEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSE------GESGPTESADSDPESES 699
           EE  +P   + E  +  +  +  + +E  K   SDSE      G +  +E+ D      S
Sbjct: 98  EERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPAS 157

Query: 700 ESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASS 759
           +S+ +   +S + +S +E   + Q  D E       + S+ + +   K ++ + + E   
Sbjct: 158 DSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELP 217

Query: 760 SDEGSDSSSSSSESEMTSESEEEQLEPASWS---RKTPPSSKSAPATKE----ISLLDLE 812
             + SDS S        S+SE E+L     S    + PP  +++ +  E      + D E
Sbjct: 218 KPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSE 277

Query: 813 DFTPPSVQ 820
              PP  Q
Sbjct: 278 SEDPPRNQ 285



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 42/146 (28%), Positives = 67/146 (45%), Gaps = 10/146 (6%)

Query: 646 EEAPDPSVRNVEVPEWTKC-SNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSK 704
           E+A  P + + E  E  +  ++  + +E  KP  SDSE E  P     SD ESE E    
Sbjct: 175 EDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQV-SDSESE-EPPRH 232

Query: 705 SSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGS 764
            +S+S + E      ++ + ED  + + S+SE  E       K ++ + + E    ++ S
Sbjct: 233 QASDSENEELPKPRISDSESEDPPRHQASDSENEE-----LPKPRISDSESEDPPRNQAS 287

Query: 765 DSSSSSSESEMTSESEEE--QLEPAS 788
           DS +        S+SE E  Q  PAS
Sbjct: 288 DSENEELPKPRVSDSESEGPQKGPAS 313



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 40/151 (26%), Positives = 65/151 (43%), Gaps = 20/151 (13%)

Query: 657 EVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESD---SKSSSESGSGE 713
           E P   + S+ E  +E  KP  SDSE E  P   A SD E+E       S S SE     
Sbjct: 201 EEPPKPRMSDSES-EELPKPQVSDSESEEPPRHQA-SDSENEELPKPRISDSESEDPPRH 258

Query: 714 SSSESDNED---------QDEDEEKGRGSESEQSE------EDGKRKTKKKVPERKGEAS 758
            +S+S+NE+         + ED  + + S+SE  E       D + +  +K P    E  
Sbjct: 259 QASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETE 318

Query: 759 SSDEGSDSSSSSSESEMTSESEEEQLEPASW 789
            +        S  +S+  ++ E+ +++  S+
Sbjct: 319 DASRHKQKPESDDDSDRENKGEDTEMQNDSF 349



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 36/138 (26%), Positives = 61/138 (44%), Gaps = 15/138 (10%)

Query: 688 TESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTK 747
           T+S + +P + + SDS    ES       +SD+E ++  E     SE+E   + G     
Sbjct: 67  TDSENDEPLNLNASDS----ESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSES 122

Query: 748 KKVPERKGEASSSDEGSDSSSSSSESE-----MTSESEEEQLEPASWSRKTPPSSKSAPA 802
           ++  +  G  S ++E  +  +S SE+E       S+SE E+L+      K+P S      
Sbjct: 123 EETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQ------KSPASDSETED 176

Query: 803 TKEISLLDLEDFTPPSVQ 820
             +  + D E   PP  Q
Sbjct: 177 ALKPQISDSESEEPPRHQ 194



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 15/130 (11%)

Query: 674 EKPFYSDSEGESGPTESADSDPESESES-DSKSSSESGSGESSSESDNEDQDEDEEKG-- 730
           +  +YS  + + G       + +S S+  D  +   SGS   S E  +E++  D E G  
Sbjct: 2   DSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLP 61

Query: 731 RGSESEQSEED------GKRKTKKKVPERKGEASSSDEGSDSSSSSSESE------MTSE 778
           +G     SE D            +++  +K   S S+E ++  +S SE+E        SE
Sbjct: 62  KGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSE 121

Query: 779 SEEEQLEPAS 788
           SEE +  P S
Sbjct: 122 SEETRKLPGS 131



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 53/233 (22%), Positives = 90/233 (38%), Gaps = 24/233 (10%)

Query: 612 LESSFKDRDHFQLGSLSHLLNAKATGYQELPDWPEEAPDPSVRNVEVPEWTKCSNREKR- 670
           ++S +   D    G  + + + + +G     D  E+       +VE     + S+RE   
Sbjct: 1   MDSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGL 60

Query: 671 --------KEKEKPFYSDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNED 722
                    E ++P   ++            D +SESE  ++  +     E  ++  ++ 
Sbjct: 61  PKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDS 120

Query: 723 QDEDEEKGRGSESEQSE-EDGKRKTKKKVPERKGEASSS--DEGSDSSSSSSESE----- 774
           + E+  K  GS+SE  E  +G     +     K  AS S  +E   S +S SE+E     
Sbjct: 121 ESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKP 180

Query: 775 --MTSESEEEQLEPASWS-RKTPPSSKSAPATKE----ISLLDLEDFTPPSVQ 820
               SESEE     AS S  + PP  + + +  E      + D E   PP  Q
Sbjct: 181 QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQ 233



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 64/250 (25%), Positives = 104/250 (41%), Gaps = 51/250 (20%)

Query: 668 EKRKEKEKPFYSDSEGESGPTESADSDPESES-ESDSKSSSESGS------GESSSESDN 720
           +K  ++EK   SDSE E+G   S   + E +   SDS+S +E  +      GES  E + 
Sbjct: 427 DKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEE 486

Query: 721 E-----DQDEDEEKGRGS--ESEQSEEDGKRKTKKKVP---------ERKGEASSSDEGS 764
           E      +D +EEKG     E+E S+ D   K  K +          +RK   S     +
Sbjct: 487 EFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRRRN 546

Query: 765 DSSSS--SSESEMTSESEEEQLEPASWSRKTPPSSKSAPATKEISLLDLEDFTPPSV--- 819
               +  S   ++ S    +  E A   R+   +++  PA K+++LL       P+V   
Sbjct: 547 RDGGTFISDADDVVSAMIVKMNEAAEEDRQL--NNQKKPALKKLTLL-------PAVVMH 597

Query: 820 ---QPVSPPAIVSTSLAADLEGLTLTDSTLVPSL---------LSPVSGVGRQELLHRVA 867
              Q +    I S  ++A  E L+      +P+L         L  +  V ++ L H  +
Sbjct: 598 LKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKH--S 655

Query: 868 GEGLAVDYTF 877
           G G AV Y +
Sbjct: 656 GIGRAVMYLY 665



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 26/95 (27%), Positives = 44/95 (46%), Gaps = 8/95 (8%)

Query: 679 SDSEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGR---GSES 735
           SD  G+   T ++DS+ E+  E   K + E    +    SD+E  +E+E       G   
Sbjct: 426 SDKSGKREKTIASDSEEEAGKELSDKKNEE----KDLFGSDSESGNEEENLIADIFGESG 481

Query: 736 EQSEEDGKRKTKKKVPERKGEASSSD-EGSDSSSS 769
           ++ EE+     ++ + E KGE    + E SDS  +
Sbjct: 482 DEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDN 516


>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
           exchanger), member 1 [Homo sapiens]
          Length = 1099

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 33/135 (24%), Positives = 60/135 (44%), Gaps = 6/135 (4%)

Query: 682 EGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEED 741
           EGE+      ++ PE E E++++   E    E+ +E   +++ EDE +    + E    +
Sbjct: 766 EGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGDNEGEDEGEIHAEDGEMKGNE 825

Query: 742 GKRKTKKKVPERKGEASSSDE------GSDSSSSSSESEMTSESEEEQLEPASWSRKTPP 795
           G+ ++++   E  GEA + ++      GSD   S  E E   E EEE+ E      +   
Sbjct: 826 GETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEE 885

Query: 796 SSKSAPATKEISLLD 810
             +     +E   LD
Sbjct: 886 EEEEEKGNEEPLSLD 900



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 36/140 (25%), Positives = 54/140 (38%), Gaps = 23/140 (16%)

Query: 645 PEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSDPESESESDSK 704
           P + P  +V    VP+        K  +KE P   +   E+   ES    P  E E+  +
Sbjct: 717 PAKLPAVTVTPAPVPDI-------KGDQKENPGGQEDVAEA---ESTGEMPGEEGETAGE 766

Query: 705 SSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGS 764
             +E  SG    E+  E + E E +G+G E E   E           E KG+    DEG 
Sbjct: 767 GETEEKSG---GETQPEGEGETETQGKGEECEDENE----------AEGKGDNEGEDEGE 813

Query: 765 DSSSSSSESEMTSESEEEQL 784
             +          E+E ++L
Sbjct: 814 IHAEDGEMKGNEGETESQEL 833



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 46/215 (21%), Positives = 79/215 (36%), Gaps = 34/215 (15%)

Query: 566 LAKYDQNYDIRDRARFTRQLIVPSEQGGALSRHAKKLFLAPKPAPVLESSFKDRDHFQLG 625
           LAK  +   +   AR   Q    S+           + + P P P ++   K+      G
Sbjct: 687 LAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENP----G 742

Query: 626 SLSHLLNAKATGYQELP----------DWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEK 675
               +  A++TG  E+P          +  E++   +    E    T+    E   E E 
Sbjct: 743 GQEDVAEAESTG--EMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEA 800

Query: 676 PFYSDSEGES---------------GPTESADSDPESESESDSKSSSESGSGESSSESDN 720
               D+EGE                G TES +   E+  E+ +        G S      
Sbjct: 801 EGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSE 860

Query: 721 EDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKG 755
           E+++E+EE+    E E+ EE  + + +++  E KG
Sbjct: 861 EEEEEEEEQ---EEEEEEEEQEEEEEEEEEEEEKG 892



 Score = 35.0 bits (79), Expect = 0.38
 Identities = 20/87 (22%), Positives = 43/87 (49%), Gaps = 8/87 (9%)

Query: 666 NREKRKEKEKPFYSDSEG--ESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQ 723
           ++E   E      +D +G  + G ++  DS+ E E E + +   E        E + E++
Sbjct: 830 SQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEE------EEQEEEEE 883

Query: 724 DEDEEKGRGSESEQSEEDGKRKTKKKV 750
           +E+EE+ +G+E   S +  + + K+ +
Sbjct: 884 EEEEEEEKGNEEPLSLDWPETRQKQAI 910


>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
           precursor [Homo sapiens]
          Length = 513

 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 46/164 (28%), Positives = 74/164 (45%), Gaps = 18/164 (10%)

Query: 646 EEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGES-GPTESADSDPESESESDSK 704
           EE+ +    + E  +    S++E   E ++   S+S G++  PT S   D E    S+  
Sbjct: 328 EESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEED 387

Query: 705 SSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGS 764
           SS      +S S  +  D +  E      ES +S ED              E SSS EG 
Sbjct: 388 SSHTLSHSKSESREEQADSESSESLNFSEESPESPED--------------ENSSSQEGL 433

Query: 765 DSSSSSSES---EMTSESEEEQLEPASWSRKTPPSSKSAPATKE 805
            S SSS+ES   E  SE ++   + +S S++   S++S  +++E
Sbjct: 434 QSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEE 477



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 42/159 (26%), Positives = 65/159 (40%), Gaps = 19/159 (11%)

Query: 668 EKRKEKEKPFYSDSEGESGPTESADSD-PESESESDSKSSSESGSGESSSE------SDN 720
           + R++ +     DS+      ES + D P SES  ++  SS+  S ES  E       DN
Sbjct: 308 QPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDN 367

Query: 721 EDQD----EDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSS--------DEGSDSSS 768
            D      ED+E    SE + S      K++ +  +   E+S S        +   D +S
Sbjct: 368 PDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENS 427

Query: 769 SSSESEMTSESEEEQLEPASWSRKTPPSSKSAPATKEIS 807
           SS E   +  S  E     S S +    S+ +  +KE S
Sbjct: 428 SSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDS 466



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 49/195 (25%), Positives = 84/195 (43%), Gaps = 15/195 (7%)

Query: 625 GSLSHLLNAKATGYQELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGE 684
           G  S   N + +G  +L + P        R  E  + ++  +    +E +    SDS   
Sbjct: 243 GENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVK----SDSTEN 298

Query: 685 SGPTESADSDPESESESDS-KSSSESGSGESSSESDNEDQDEDEEKGRGSE--SEQSEED 741
           S   ++  S P  +S+ DS + S E+ S E S   D    +  +E    S+  S +S+E+
Sbjct: 299 SNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEE 358

Query: 742 GKRKTKKKVPERKGEASSSDEGSDSS---SSSSESEMTSESEEEQL-----EPASWSRKT 793
              +++   P+         E SDSS   SS + S   SES EEQ      E  ++S ++
Sbjct: 359 VVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEES 418

Query: 794 PPSSKSAPATKEISL 808
           P S +   ++ +  L
Sbjct: 419 PESPEDENSSSQEGL 433



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 17/163 (10%)

Query: 623 QLGSLSHLLNAKATGYQELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSE 682
           Q  +LS   N+  +  + + +   + PDP+   VE  E +  S              DS 
Sbjct: 342 QEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEE------------DSS 389

Query: 683 GESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDG 742
                ++S   + +++SE     SSES +    S    ED++   ++G  S S  +E   
Sbjct: 390 HTLSHSKSESREEQADSE-----SSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQS 444

Query: 743 KRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLE 785
           +    ++      ++S S E S+S+ S S SE   + +  ++E
Sbjct: 445 EESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIE 487



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 36/153 (23%), Positives = 53/153 (34%), Gaps = 25/153 (16%)

Query: 647 EAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEG------------------ESGPT 688
           +AP P + + E  E +K S+ E+  E         EG                   +G  
Sbjct: 39  QAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKG 98

Query: 689 ESADSDPESESESDSKSSSESGSG-----ESSSESDNEDQDEDEEKGRGSESEQSEEDGK 743
                D E +S  D+    +SG G     E  +     D+D D+      ES    +D  
Sbjct: 99  GDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSA 158

Query: 744 RKTKKKVPERKGE--ASSSDEGSDSSSSSSESE 774
           + T  +  E   E    S  EG DS+  S   E
Sbjct: 159 QDTTSESRELDNEDRVDSKPEGGDSTQESESEE 191



 Score = 37.7 bits (86), Expect = 0.059
 Identities = 26/106 (24%), Positives = 47/106 (44%), Gaps = 5/106 (4%)

Query: 679 SDSEGESGPTESADSDPES-ESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQ 737
           S+     G   + D+  ES E +++ +  S+   G+S+ ES++E+       G GS+ E 
Sbjct: 147 SEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEH----WVGGGSDGES 202

Query: 738 SEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQ 783
           S  DG     + +     E+  S+ G+   +S+      S    EQ
Sbjct: 203 SHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQ 248



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 10/106 (9%)

Query: 689 ESADSDPESESESD---SKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRK 745
           E  DS  ESESE       S  ES  G+ S E D+E    D+ +   SE   S  +    
Sbjct: 179 EGGDSTQESESEEHWVGGGSDGESSHGDGS-ELDDEGMQSDDPESIRSERGNSRMNSAGM 237

Query: 746 TKKKVPERKGEASSSDEGSD------SSSSSSESEMTSESEEEQLE 785
             K+  E   +A++ D G        S     +S ++ E +  +L+
Sbjct: 238 KSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELD 283



 Score = 30.4 bits (67), Expect = 9.4
 Identities = 34/152 (22%), Positives = 59/152 (38%), Gaps = 25/152 (16%)

Query: 662 TKCSNREKRKEKEKPFYSDSEGESGPTESADS---------DPESESESDSKSSSES--- 709
           T+  N E    +E   +  ++  + P ES++S         +  +E  SDS  S E    
Sbjct: 20  TRYQNNESEDSEEWKGHL-AQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGS 78

Query: 710 ---------GSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSS 760
                      G S S     D  +D+E   G ++   ++ G     ++  E       S
Sbjct: 79  DDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQ--EGGNSRLGS 136

Query: 761 DEGSDSSSSSSESEMTSESEEEQLEPASWSRK 792
           DE SD +  +SE E   + ++   +  S SR+
Sbjct: 137 DEDSDDTIQASE-ESAPQGQDSAQDTTSESRE 167


>gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
           precursor [Homo sapiens]
          Length = 497

 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 46/164 (28%), Positives = 74/164 (45%), Gaps = 18/164 (10%)

Query: 646 EEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGES-GPTESADSDPESESESDSK 704
           EE+ +    + E  +    S++E   E ++   S+S G++  PT S   D E    S+  
Sbjct: 312 EESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEED 371

Query: 705 SSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGS 764
           SS      +S S  +  D +  E      ES +S ED              E SSS EG 
Sbjct: 372 SSHTLSHSKSESREEQADSESSESLNFSEESPESPED--------------ENSSSQEGL 417

Query: 765 DSSSSSSES---EMTSESEEEQLEPASWSRKTPPSSKSAPATKE 805
            S SSS+ES   E  SE ++   + +S S++   S++S  +++E
Sbjct: 418 QSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEE 461



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 42/159 (26%), Positives = 65/159 (40%), Gaps = 19/159 (11%)

Query: 668 EKRKEKEKPFYSDSEGESGPTESADSD-PESESESDSKSSSESGSGESSSE------SDN 720
           + R++ +     DS+      ES + D P SES  ++  SS+  S ES  E       DN
Sbjct: 292 QPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDN 351

Query: 721 EDQD----EDEEKGRGSESEQSEEDGKRKTKKKVPERKGEASSS--------DEGSDSSS 768
            D      ED+E    SE + S      K++ +  +   E+S S        +   D +S
Sbjct: 352 PDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENS 411

Query: 769 SSSESEMTSESEEEQLEPASWSRKTPPSSKSAPATKEIS 807
           SS E   +  S  E     S S +    S+ +  +KE S
Sbjct: 412 SSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDS 450



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 49/195 (25%), Positives = 84/195 (43%), Gaps = 15/195 (7%)

Query: 625 GSLSHLLNAKATGYQELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGE 684
           G  S   N + +G  +L + P        R  E  + ++  +    +E +    SDS   
Sbjct: 227 GENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVK----SDSTEN 282

Query: 685 SGPTESADSDPESESESDS-KSSSESGSGESSSESDNEDQDEDEEKGRGSE--SEQSEED 741
           S   ++  S P  +S+ DS + S E+ S E S   D    +  +E    S+  S +S+E+
Sbjct: 283 SNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEE 342

Query: 742 GKRKTKKKVPERKGEASSSDEGSDSS---SSSSESEMTSESEEEQL-----EPASWSRKT 793
              +++   P+         E SDSS   SS + S   SES EEQ      E  ++S ++
Sbjct: 343 VVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEES 402

Query: 794 PPSSKSAPATKEISL 808
           P S +   ++ +  L
Sbjct: 403 PESPEDENSSSQEGL 417



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 17/163 (10%)

Query: 623 QLGSLSHLLNAKATGYQELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSE 682
           Q  +LS   N+  +  + + +   + PDP+   VE  E +  S              DS 
Sbjct: 326 QEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEE------------DSS 373

Query: 683 GESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDG 742
                ++S   + +++SE     SSES +    S    ED++   ++G  S S  +E   
Sbjct: 374 HTLSHSKSESREEQADSE-----SSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQS 428

Query: 743 KRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLE 785
           +    ++      ++S S E S+S+ S S SE   + +  ++E
Sbjct: 429 EESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIE 471



 Score = 37.7 bits (86), Expect = 0.059
 Identities = 26/106 (24%), Positives = 47/106 (44%), Gaps = 5/106 (4%)

Query: 679 SDSEGESGPTESADSDPES-ESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQ 737
           S+     G   + D+  ES E +++ +  S+   G+S+ ES++E+       G GS+ E 
Sbjct: 131 SEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEH----WVGGGSDGES 186

Query: 738 SEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQ 783
           S  DG     + +     E+  S+ G+   +S+      S    EQ
Sbjct: 187 SHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQ 232



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 33/140 (23%), Positives = 54/140 (38%), Gaps = 15/140 (10%)

Query: 647 EAPDPSVRNVEVPEWTKCSNREKRKEKEKPF-----YSDSEGESGPTESADSDPESESES 701
           +AP P + N +  + T+        + +  +     +S S G+ G  +  D D   +S  
Sbjct: 39  QAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDED---DSGD 95

Query: 702 DSKSSSESGSG-----ESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGE 756
           D+    +SG G     E  +     D+D D+      ES    +D  + T  +  E   E
Sbjct: 96  DTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNE 155

Query: 757 --ASSSDEGSDSSSSSSESE 774
               S  EG DS+  S   E
Sbjct: 156 DRVDSKPEGGDSTQESESEE 175



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 10/106 (9%)

Query: 689 ESADSDPESESESD---SKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRK 745
           E  DS  ESESE       S  ES  G+ S E D+E    D+ +   SE   S  +    
Sbjct: 163 EGGDSTQESESEEHWVGGGSDGESSHGDGS-ELDDEGMQSDDPESIRSERGNSRMNSAGM 221

Query: 746 TKKKVPERKGEASSSDEGSD------SSSSSSESEMTSESEEEQLE 785
             K+  E   +A++ D G        S     +S ++ E +  +L+
Sbjct: 222 KSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELD 267



 Score = 32.3 bits (72), Expect = 2.5
 Identities = 29/126 (23%), Positives = 48/126 (38%), Gaps = 16/126 (12%)

Query: 680 DSEGESGPTESADSDPESESESDSKSSSESGSGE-------------SSSESDNEDQDED 726
           DSE   G    A + P +  +    + SE G G              S S     D  +D
Sbjct: 29  DSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDD 88

Query: 727 EEKGRGSESEQSEEDGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEP 786
           +E   G ++   ++ G     ++  E       SDE SD +  +SE E   + ++   + 
Sbjct: 89  DEDDSGDDTFGDDDSGPGPKDRQ--EGGNSRLGSDEDSDDTIQASE-ESAPQGQDSAQDT 145

Query: 787 ASWSRK 792
            S SR+
Sbjct: 146 TSESRE 151


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.357 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,589,431
Number of Sequences: 37866
Number of extensions: 1862725
Number of successful extensions: 32402
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 723
Number of HSP's successfully gapped in prelim test: 1070
Number of HSP's that attempted gapping in prelim test: 12033
Number of HSP's gapped (non-prelim): 10924
length of query: 1082
length of database: 18,247,518
effective HSP length: 113
effective length of query: 969
effective length of database: 13,968,660
effective search space: 13535631540
effective search space used: 13535631540
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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