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Search of human proteins with 34452732
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent
Rac exchange factor 1 [Homo sapiens]
(1659 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 3331 0.0
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 1831 0.0
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 1148 0.0
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 223 1e-57
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 223 2e-57
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 202 2e-51
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 202 2e-51
gi|189571664 DEP domain containing 6 [Homo sapiens] 141 5e-33
gi|71274148 pleckstrin homology domain containing, family G (wit... 122 3e-27
gi|197116361 inositol polyphosphate-4-phosphatase, type 1 isofor... 120 1e-26
gi|197116359 inositol polyphosphate-4-phosphatase, type 1 isofor... 120 1e-26
gi|4504705 inositol polyphosphate-4-phosphatase, type 1 isoform ... 120 1e-26
gi|4755140 inositol polyphosphate-4-phosphatase, type 1 isoform ... 120 1e-26
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 117 9e-26
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 117 1e-25
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 112 2e-24
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 112 2e-24
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom... 112 3e-24
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] 111 5e-24
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 111 7e-24
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 109 3e-23
gi|24797153 faciogenital dysplasia protein [Homo sapiens] 108 6e-23
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 106 2e-22
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 105 3e-22
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 104 8e-22
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 103 1e-21
gi|83715966 hypothetical protein LOC389337 [Homo sapiens] 103 2e-21
gi|39930351 dynamin binding protein [Homo sapiens] 100 1e-20
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 100 1e-20
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 100 2e-20
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 3331 bits (8636), Expect = 0.0
Identities = 1659/1659 (100%), Positives = 1659/1659 (100%)
Query: 1 MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGT 60
MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGT
Sbjct: 1 MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGT 60
Query: 61 ERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYC 120
ERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYC
Sbjct: 61 ERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYC 120
Query: 121 LHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGG 180
LHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGG
Sbjct: 121 LHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGG 180
Query: 181 RKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINET 240
RKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINET
Sbjct: 181 RKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINET 240
Query: 241 KRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVY 300
KRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVY
Sbjct: 241 KRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVY 300
Query: 301 CKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWK 360
CKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWK
Sbjct: 301 CKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWK 360
Query: 361 IHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMM 420
IHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMM
Sbjct: 361 IHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMM 420
Query: 421 MNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVS 480
MNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVS
Sbjct: 421 MNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVS 480
Query: 481 DKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYK 540
DKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYK
Sbjct: 481 DKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYK 540
Query: 541 SVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEE 600
SVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEE
Sbjct: 541 SVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEE 600
Query: 601 MEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVA 660
MEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVA
Sbjct: 601 MEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVA 660
Query: 661 GLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLC 720
GLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLC
Sbjct: 661 GLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLC 720
Query: 721 FQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREE 780
FQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREE
Sbjct: 721 FQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREE 780
Query: 781 ALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSP 840
ALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSP
Sbjct: 781 ALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSP 840
Query: 841 MVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVEN 900
MVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVEN
Sbjct: 841 MVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVEN 900
Query: 901 CRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPH 960
CRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPH
Sbjct: 901 CRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPH 960
Query: 961 PLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQH 1020
PLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQH
Sbjct: 961 PLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQH 1020
Query: 1021 CITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYL 1080
CITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYL
Sbjct: 1021 CITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYL 1080
Query: 1081 QLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSD 1140
QLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSD
Sbjct: 1081 QLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSD 1140
Query: 1141 HGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGS 1200
HGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGS
Sbjct: 1141 HGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGS 1200
Query: 1201 GDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEF 1260
GDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEF
Sbjct: 1201 GDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEF 1260
Query: 1261 KQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQ 1320
KQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQ
Sbjct: 1261 KQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQ 1320
Query: 1321 LRRDAIFCQALVAAVCTFSEQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHC 1380
LRRDAIFCQALVAAVCTFSEQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHC
Sbjct: 1321 LRRDAIFCQALVAAVCTFSEQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHC 1380
Query: 1381 QSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVI 1440
QSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVI
Sbjct: 1381 QSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVI 1440
Query: 1441 FYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEK 1500
FYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEK
Sbjct: 1441 FYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEK 1500
Query: 1501 VQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSV 1560
VQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSV
Sbjct: 1501 VQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSV 1560
Query: 1561 GAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIM 1620
GAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIM
Sbjct: 1561 GAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIM 1620
Query: 1621 RKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL 1659
RKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL
Sbjct: 1621 RKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL 1659
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 1831 bits (4743), Expect = 0.0
Identities = 938/1639 (57%), Positives = 1207/1639 (73%), Gaps = 58/1639 (3%)
Query: 31 SSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKG 90
S G +A++ E+QLRLR+CVL+E+ TERDYVGTL FL SAFLHR+ Q A V+K
Sbjct: 5 SRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKN 64
Query: 91 LTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCS 150
+TEE VK+LFSNIEDIL VHK+FL +E CLHPEP +Q E+G FL FKDKF +Y+EYCS
Sbjct: 65 VTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCS 124
Query: 151 NHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELA 210
NHEKA +LL+ELNKI T+R FLL+CMLLGGRK TD+PLEGYL++PIQRICKYPL+LKEL
Sbjct: 125 NHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELL 184
Query: 211 KRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICT 270
KRTP KH D+ AV ALQAMK VCSNINE KRQMEKLE LE+ QSHIEGWEGSN+TD CT
Sbjct: 185 KRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCT 244
Query: 271 QLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGR 330
++L+ G LLKIS+GNIQER FFLFDNLLVYCKRK R + K+ S +G Y+FRGR
Sbjct: 245 EMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKA-----STDGHRYLFRGR 299
Query: 331 INTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIRE 390
INTEVMEVENV+DGTAD+HS+G+ V NGWKIHNTAKNKWFVCMAKT EEK +W +AI++E
Sbjct: 300 INTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359
Query: 391 REQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAW 450
RE+R+ LKLGME+D +VMI+E+GEKLY MM ++ NLIKDR+RKL+T PKCFLG+EFV+W
Sbjct: 360 RERRKGLKLGMEQDTWVMISEQGEKLYKMMC-RQGNLIKDRKRKLTTFPKCFLGSEFVSW 418
Query: 451 LLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDI 510
LLEIGEI + EEGV+LGQALLENGIIHHV+DKHQFK EQ++YRFRYDDGT+ R+E++D+
Sbjct: 419 LLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDV 478
Query: 511 MSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVG 570
+SKGVRLYCRLHSL+TPVI+D+DYHL+TYKSV+ +KL+DWL+AQGDC+TREEA+ GVG
Sbjct: 479 ISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVG 538
Query: 571 LCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILP 630
LC+NGFMHHVLEKSEF+DE FRF +DEEMEG++ K++ +++D K+VEN++AK LLI
Sbjct: 539 LCDNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKS 598
Query: 631 QEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQ 690
E YGF +E+KNK ++K V++GS AE+AG++VG+KI++IN DLVF+RPF+EV+ L
Sbjct: 599 NEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKS 658
Query: 691 SFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGLCAGQC 750
SR+PLR+LV+TK +E +KIPD D L FQIRG P V+AVGRG+ A AAGL GQC
Sbjct: 659 CLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQC 718
Query: 751 ILKVNGSNVMNDGAPEVLEHFQAFRS-RREEALGLYQWIYHTHEDAQEARASQEASTEDP 809
I+KVNG NV + V+ H A R RR QW+Y++ E AQE + S P
Sbjct: 719 IIKVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQE---DLQKSHSKP 775
Query: 810 SGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHV 869
G++A + + + V+LTVDNVHLE+GVVYEY STAG++C+V
Sbjct: 776 PGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNV 835
Query: 870 LEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDTKLES 929
+EK++EP+G F LTAKILEA A +D FV+NC L +L+ I T +F +C ++E
Sbjct: 836 VEKMIEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEH 895
Query: 930 IGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVG 989
+ QRI+ Y++F+ LK+R P FKQA + PL DFCPTNCH+N+MEVSYPKT+ S+G
Sbjct: 896 LCQRISSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLG 955
Query: 990 RSFSIRFGRKP----SLIGLDPEQGHLNPMSYTQHCITTMAAPSWKCLPAAEGDPQGQGL 1045
+F ++ + EQG L+PM Y QH ITTMAAPS GL
Sbjct: 956 SAFGVQLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPS--------------GL 1001
Query: 1046 HDGSFGPASGTLGQED-RGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLL 1104
+LGQ+D GL +LLK+ED E QD Y +L KL ALKE++ V QI+ LL
Sbjct: 1002 ----------SLGQQDGHGLRYLLKEEDLETQDIYQKLLGKLQTALKEVEMCVCQIDDLL 1051
Query: 1105 STITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVCFKVAEEDQEDSGHDTM 1164
S+IT + E +S ++ +S+ ++ + K+VCF VA ++QEDSGHDT+
Sbjct: 1052 SSITY--------SPKLERKTSEGIIPTDSDNEKGERNS-KRVCFNVAGDEQEDSGHDTI 1102
Query: 1165 SYRDSYSECNSNRDSVLSYTSVRSN--SSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCL 1222
S RDSYS+CNSNR+S+ S+TS+ S+ SSY SDEM SGDELP +RI DKQDK+H CL
Sbjct: 1103 SNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPLSVRISHDKQDKIHSCL 1162
Query: 1223 EHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDP 1282
EHLF+QVDSI LLKG + RAF++TK+ LQEF+Q+ E + +++ I++DP
Sbjct: 1163 EHLFSQVDSITNLLKGQAVVRAFDQTKYLTPGRGLQEFQQEMEPKLSCPKRLRLHIKQDP 1222
Query: 1283 WNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSEQL 1342
WNLP+S++TL NI+++VE+ K +LLLALL+ +D+E QLRRD +FCQ LVA VC FSEQL
Sbjct: 1223 WNLPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDSETQLRRDMVFCQTLVATVCAFSEQL 1282
Query: 1343 LAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVT 1402
+AAL ++N+ E E + +ASR+WL+Q+A GVL H QSLLSP + +E+ MLED V
Sbjct: 1283 MAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSP-NLTDEQAMLEDTLVA 1341
Query: 1403 LSELDNVTFSFKQLDEN-YVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASL 1461
L +L+ V+F FK +E VAN + Y EGSRQALKV FY+DSYHF +LP RL+ G
Sbjct: 1342 LFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVYFYIDSYHFEQLPQRLKNGGGF 1401
Query: 1462 RLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTD 1521
++H LF + LE++EG + + E+ Q INA SLEKV+QY +KLRAFYL++SN P +
Sbjct: 1402 KIHPVLFAQALESMEGYYYRDNVSVEEFQAQINAASLEKVKQYNQKLRAFYLDKSNSPPN 1461
Query: 1522 ASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAA------GSVGAGLIPISSELCYRL 1575
+++ A +D+L+RP+NALDEL RL+ SF+ K AA + G GL+ +SSELC RL
Sbjct: 1462 STSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACANTACSASGVGLLSVSSELCNRL 1521
Query: 1576 GACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLR 1635
GAC ++MC +G+ R TLSV+LEQA ILARSHGL P+ IMQATD+MRKQG RV+ AKNL
Sbjct: 1522 GACHIIMCSSGVHRCTLSVTLEQAIILARSHGLPPRYIMQATDVMRKQGARVQNTAKNLG 1581
Query: 1636 VKDQMPQGAPRLYRLCQPP 1654
V+D+ PQ APRLY+LC+PP
Sbjct: 1582 VRDRTPQSAPRLYKLCEPP 1600
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 1148 bits (2969), Expect = 0.0
Identities = 566/913 (61%), Positives = 711/913 (77%), Gaps = 10/913 (1%)
Query: 31 SSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKG 90
S G +A++ E+QLRLR+CVL+E+ TERDYVGTL FL SAFLHR+ Q A V+K
Sbjct: 5 SRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKN 64
Query: 91 LTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCS 150
+TEE VK+LFSNIEDIL VHK+FL +E CLHPEP +Q E+G FL FKDKF +Y+EYCS
Sbjct: 65 VTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCS 124
Query: 151 NHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELA 210
NHEKA +LL+ELNKI T+R FLL+CMLLGGRK TD+PLEGYL++PIQRICKYPL+LKEL
Sbjct: 125 NHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELL 184
Query: 211 KRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICT 270
KRTP KH D+ AV ALQAMK VCSNINE KRQMEKLE LE+ QSHIEGWEGSN+TD CT
Sbjct: 185 KRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCT 244
Query: 271 QLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGR 330
++L+ G LLKIS+GNIQER FFLFDNLLVYCKRK R + K+ S +G Y+FRGR
Sbjct: 245 EMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKA-----STDGHRYLFRGR 299
Query: 331 INTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIRE 390
INTEVMEVENV+DGTAD+HS+G+ V NGWKIHNTAKNKWFVCMAKT EEK +W +AI++E
Sbjct: 300 INTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359
Query: 391 REQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAW 450
RE+R+ LKLGME+D +VMI+E+GEKLY MM ++ NLIKDR+RKL+T PKCFLG+EFV+W
Sbjct: 360 RERRKGLKLGMEQDTWVMISEQGEKLYKMMC-RQGNLIKDRKRKLTTFPKCFLGSEFVSW 418
Query: 451 LLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDI 510
LLEIGEI + EEGV+LGQALLENGIIHHV+DKHQFK EQ++YRFRYDDGT+ R+E++D+
Sbjct: 419 LLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDV 478
Query: 511 MSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVG 570
+SKGVRLYCRLHSL+TPVI+D+DYHL+TYKSV+ +KL+DWL+AQGDC+TREEA+ GVG
Sbjct: 479 ISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVG 538
Query: 571 LCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILP 630
LC+NGFMHHVLEKSEF+DE FRF +DEEMEG++ K++ +++D K+VEN++AK LLI
Sbjct: 539 LCDNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKS 598
Query: 631 QEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQ 690
E YGF +E+KNK ++K V++GS AE+AG++VG+KI++IN DLVF+RPF+EV+ L
Sbjct: 599 NEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKS 658
Query: 691 SFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGLCAGQC 750
SR+PLR+LV+TK +E +KIPD D L FQIRG P V+AVGRG+ A AAGL GQC
Sbjct: 659 CLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQC 718
Query: 751 ILKVNGSNVMNDGAPEVLEHFQAFRS-RREEALGLYQWIYHTHEDAQEARASQEASTEDP 809
I+KVNG NV + V+ H A R RR QW+Y++ E AQE + S P
Sbjct: 719 IIKVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQE---DLQKSHSKP 775
Query: 810 SGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHV 869
G++A + + + V+LTVDNVHLE+GVVYEY STAG++C+V
Sbjct: 776 PGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNV 835
Query: 870 LEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDTKLES 929
+EK++EP+G F LTAKILEA A +D FV+NC L +L+ I T +F +C ++E
Sbjct: 836 VEKMIEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEH 895
Query: 930 IGQRIACYQEFAA 942
+ QRI+ Y++ A
Sbjct: 896 LCQRISSYKKVQA 908
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 223 bits (568), Expect = 1e-57
Identities = 150/435 (34%), Positives = 228/435 (52%), Gaps = 45/435 (10%)
Query: 8 EPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGT 67
EP D A P A + A G A A+ S+ Q+R V+NEIL TERDY+
Sbjct: 256 EPADDDA-------PLAGNSGAEDGG----AEAQSSKDQMRTN--VINEILSTERDYIKH 302
Query: 68 LRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQS 127
LR + ++ + R+ AD +EE ++ +F NIEDI K F+ ALE + E
Sbjct: 303 LRDICEGYVRQCRKR-ADM----FSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPH 357
Query: 128 QHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIP 187
ELG FL+ + F +Y EYC+NH A L L K+ F +C LL +K DI
Sbjct: 358 LSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLL--QKMIDIS 415
Query: 188 LEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKL 247
L+G+LL+P+Q+ICKYPL L EL K T +H D V++AL AMK V INE KR++E +
Sbjct: 416 LDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENI 475
Query: 248 EALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKIS--AGNIQERAFFLFDNLLVYCKRKS 305
+ + Q QS IE WEG +L ++L+ G L +++ Q+R FFLFD+ L+YCK+
Sbjct: 476 DKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKK-- 533
Query: 306 RVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDG-TADYHSNGYTVTNGWKIHNT 364
+ + ++GR++ + +EV ++EDG D H ++ N +++H
Sbjct: 534 ------------DLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLH---VSIKNAFRLHRG 578
Query: 365 AKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMNKK 424
A + + E+KQ+WL A REREQ + ++++ I E K + +K+
Sbjct: 579 ATGDSHLLCTRKPEQKQRWLKAFAREREQ-----VQLDQETGFSITELQRKQAMLNASKQ 633
Query: 425 VNLIKDRRRKLSTVP 439
K + R+ + P
Sbjct: 634 QVTGKPKGRRTAAPP 648
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 223 bits (567), Expect = 2e-57
Identities = 143/389 (36%), Positives = 210/389 (53%), Gaps = 40/389 (10%)
Query: 8 EPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGT 67
EP D A P A + A G A A+ S+ Q+R V+NEIL TERDY+
Sbjct: 256 EPADDDA-------PLAGNSGAEDGG----AEAQSSKDQMRTN--VINEILSTERDYIKH 302
Query: 68 LRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQS 127
LR + ++ + R+ AD +EE ++ +F NIEDI K F+ ALE + E
Sbjct: 303 LRDICEGYVRQCRKR-ADM----FSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPH 357
Query: 128 QHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIP 187
ELG FL+ + F +Y EYC+NH A L L K+ F +C LL +K DI
Sbjct: 358 LSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLL--QKMIDIS 415
Query: 188 LEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKL 247
L+G+LL+P+Q+ICKYPL L EL K T +H D V++AL AMK V INE KR++E +
Sbjct: 416 LDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENI 475
Query: 248 EALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKIS--AGNIQERAFFLFDNLLVYCKRKS 305
+ + Q QS IE WEG +L ++L+ G L +++ Q+R FFLFD+ L+YCK+
Sbjct: 476 DKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKK-- 533
Query: 306 RVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDG-TADYHSNGYTVTNGWKIHNT 364
+ + ++GR++ + +EV ++EDG D H ++ N +++H
Sbjct: 534 ------------DLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLH---VSIKNAFRLHRG 578
Query: 365 AKNKWFVCMAKTAEEKQKWLDAIIREREQ 393
A + + E+KQ+WL A REREQ
Sbjct: 579 ATGDSHLLCTRKPEQKQRWLKAFAREREQ 607
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 202 bits (515), Expect = 2e-51
Identities = 128/378 (33%), Positives = 208/378 (55%), Gaps = 31/378 (8%)
Query: 41 RESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLF 100
R E + ++R V+ EI+ TER Y+ LR + ++ + R++ T + +F
Sbjct: 232 RHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGM-----FTVAQLATIF 286
Query: 101 SNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLV 160
NIEDI + + FL LE + E E+G+ FL+ ++ F +Y EYC+NH A L
Sbjct: 287 GNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELA 346
Query: 161 ELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDH 220
L K R F +C LL ++ DI ++G+LL+P+Q+ICKYPL L EL K T +H D+
Sbjct: 347 NLMKQGKYRHFFEACRLL--QQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDY 404
Query: 221 PAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLK 280
+++A +AMK V INE KR++E ++ + + Q I GWEG ++ D ++L+ G L K
Sbjct: 405 SNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTK 464
Query: 281 IS-AGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVE 339
I+ G Q+R FFLFD+ LV CK+ + + ++GR++ + ME+
Sbjct: 465 ITKQGKSQQRTFFLFDHQLVSCKK--------------DLLRRDMLYYKGRLDMDEMELV 510
Query: 340 NVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQ-RESLK 398
++ DG D N +V N +K+ + ++ ++ AK E+K +WL A ER + +E +
Sbjct: 511 DLGDG-RDKDCN-LSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQACADERRRVQEDKE 568
Query: 399 LGMERDAYVMIAEKGEKL 416
+GME I+E +KL
Sbjct: 569 MGME------ISENQKKL 580
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 202 bits (514), Expect = 2e-51
Identities = 124/365 (33%), Positives = 196/365 (53%), Gaps = 26/365 (7%)
Query: 41 RESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLF 100
R + + ++R V+NEI+ TER Y+ L+ + +L + R+ ++E +KV+F
Sbjct: 95 RPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKR-----RDMFSDEQLKVIF 149
Query: 101 SNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLV 160
NIEDI F+ LE + + E+G FL+ +D F +Y EYC+NH A L
Sbjct: 150 GNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELS 209
Query: 161 ELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDH 220
+L K + F +C LL ++ DI ++G+LL+P+Q+ICKYPL L EL K T H D+
Sbjct: 210 KLMKDSRYQHFFEACRLL--QQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDY 267
Query: 221 PAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLK 280
V +AL M+ V INE KR++E ++ + Q Q+ + WEG ++ D ++L+ G +
Sbjct: 268 RYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAW 327
Query: 281 I--SAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEV 338
I G Q+R FFLFD+ +V CK+ I + ++GRI+ + EV
Sbjct: 328 IYQPYGRNQQRVFFLFDHQMVLCKK--------------DLIRRDILYYKGRIDMDKYEV 373
Query: 339 ENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQ-RESL 397
++EDG D ++ N +K+HN + + AK EEK +WL A ER+ +E
Sbjct: 374 VDIEDGRDD--DFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDE 431
Query: 398 KLGME 402
K+G E
Sbjct: 432 KIGFE 436
>gi|189571664 DEP domain containing 6 [Homo sapiens]
Length = 409
Score = 141 bits (356), Expect = 5e-33
Identities = 114/380 (30%), Positives = 183/380 (48%), Gaps = 30/380 (7%)
Query: 392 EQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWL 451
+QRE +ER A V++ GE+L + +KV IKDRR L T P CF+ E + WL
Sbjct: 23 QQRE-----LERMAEVLVT--GEQLRLRLHEEKV--IKDRRHHLKTYPNCFVAKELIDWL 73
Query: 452 LEIGEISKTEEGVNLGQALLENGIIHHVSDKH-QFKNEQVMYRFRYDDGTYKARSELEDI 510
+E E S E + L Q L + GIIHHV D+H +FK+ ++ YRFR DDGT+ +E++
Sbjct: 74 IEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAF 133
Query: 511 MSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVG 570
M +G RLY +L S +++ R+ Y+ S+ +DWL+ +G+ TR+EA L
Sbjct: 134 M-RGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATTRKEAEQLCHR 192
Query: 571 LCNNGFMHHVLEKSEFRDESQYFRFHAD-------EEMEGTSSKNKQLRNDFKLVENILA 623
L +G + HV K F D + ++F + E+ S + Q +D L
Sbjct: 193 LMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQETHDSPF---CLR 249
Query: 624 KRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRP--F 681
K+ + + + + +V +V+R S++ G Y + + P
Sbjct: 250 KQSHDNRKSTSF-MSVSPSKEIKIVSAVRRSSMS-----SCGSSGYFSSSPTLSSSPPVL 303
Query: 682 SEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAM 741
+S+L + S L A A++ I F +RG+ P ++ AV A
Sbjct: 304 CNPKSVLKRPVTSEE-LLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAA 362
Query: 742 AAGLCAGQCILKVNGSNVMN 761
AAG+ Q ++ VNG NV++
Sbjct: 363 AAGMKVCQFVVSVNGLNVLH 382
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 122 bits (306), Expect = 3e-27
Identities = 93/298 (31%), Positives = 146/298 (48%), Gaps = 21/298 (7%)
Query: 10 GGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLR 69
G A + + PRA + P A + S + L + V+ EIL TER YV L+
Sbjct: 75 GQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDR-VVQEILETERTYVQDLK 133
Query: 70 FLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQH 129
+ +L IR D + L E LF NI+DI + + L LE C + +P +
Sbjct: 134 SIVEDYLDCIR----DQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENCEN-DPVA-- 186
Query: 130 ELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTT---DI 186
+ F+ ++F +Y +YC+N+ +++ +L E + + F R+ T +
Sbjct: 187 -IAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRE------RQETLKHSL 239
Query: 187 PLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEK 246
PL YLL P+QRI KY LLL E+ + V A+ M+ V +IN+ KR+ E
Sbjct: 240 PLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEH 299
Query: 247 LEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRK 304
L+++QS + W+G +LT +L+L+GT A N ER FLFD LL+ K++
Sbjct: 300 AVRLQEIQSLLTNWKGPDLTSY-GELVLEGTFRIQRAKN--ERTLFLFDKLLLITKKR 354
>gi|197116361 inositol polyphosphate-4-phosphatase, type 1 isoform c
[Homo sapiens]
Length = 972
Score = 120 bits (300), Expect = 1e-26
Identities = 101/352 (28%), Positives = 157/352 (44%), Gaps = 45/352 (12%)
Query: 1289 IKTLVDNIQRYVEDGKNQLLLALLK------CTDTELQLRRDAIFCQALVAAVCTFSEQL 1342
+ TL D + + K ++ L++ T LQ RRD +FCQ L A +C F +L
Sbjct: 629 LTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKL 688
Query: 1343 LAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVT 1402
L +++G +L Q+ G+L +SLLS T EE MLED+ +
Sbjct: 689 RNCL----HDDG------------FLRQLYTIGLLAQFESLLS--TYGEELAMLEDMSLG 730
Query: 1403 LSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLR 1462
+ +L NVTF Q + A+ ++ I G+R V L F LP ++ G LR
Sbjct: 731 IMDLRNVTFKVTQATSS--ASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLR 788
Query: 1463 LHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDA 1522
+ LF + + L + LQ+ IN +SL ++ Y+ + + L LP
Sbjct: 789 VQPVLFNVGINEQQTLAERFGDTS--LQEVINVESLVRLNSYFEQFKEV-LPEDCLPRSR 845
Query: 1523 STTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSVGAGLIPISSELCYRLGACQMVM 1582
S T L EL R + VH A + ++ ++E+C RL +
Sbjct: 846 SQTC------------LPELLRFLGQNVH----ARKNKNVDILWQAAEICRRLNGVRFTS 889
Query: 1583 CGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNL 1634
C + R+ +SV+LEQ IL HG+ P+ QA + MR +G R E KN+
Sbjct: 890 CKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNV 941
Score = 32.7 bits (73), Expect = 3.0
Identities = 32/124 (25%), Positives = 51/124 (41%), Gaps = 10/124 (8%)
Query: 856 VYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMP 915
+Y + +T G +LE++ E + + ++ D+ V L LS ++
Sbjct: 232 MYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESL- 290
Query: 916 HFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHIN 975
R T+ ++I I YQE L P FK + L+ L+F PTN HI
Sbjct: 291 ----RRQIVTQYQTI---ILTYQENLTDLHQYRGPSFKASSLKADKK--LEFVPTNLHIQ 341
Query: 976 LMEV 979
M V
Sbjct: 342 RMRV 345
>gi|197116359 inositol polyphosphate-4-phosphatase, type 1 isoform d
[Homo sapiens]
Length = 977
Score = 120 bits (300), Expect = 1e-26
Identities = 101/352 (28%), Positives = 157/352 (44%), Gaps = 45/352 (12%)
Query: 1289 IKTLVDNIQRYVEDGKNQLLLALLK------CTDTELQLRRDAIFCQALVAAVCTFSEQL 1342
+ TL D + + K ++ L++ T LQ RRD +FCQ L A +C F +L
Sbjct: 634 LTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKL 693
Query: 1343 LAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVT 1402
L +++G +L Q+ G+L +SLLS T EE MLED+ +
Sbjct: 694 RNCL----HDDG------------FLRQLYTIGLLAQFESLLS--TYGEELAMLEDMSLG 735
Query: 1403 LSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLR 1462
+ +L NVTF Q + A+ ++ I G+R V L F LP ++ G LR
Sbjct: 736 IMDLRNVTFKVTQATSS--ASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLR 793
Query: 1463 LHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDA 1522
+ LF + + L + LQ+ IN +SL ++ Y+ + + L LP
Sbjct: 794 VQPVLFNVGINEQQTLAERFGDTS--LQEVINVESLVRLNSYFEQFKEV-LPEDCLPRSR 850
Query: 1523 STTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSVGAGLIPISSELCYRLGACQMVM 1582
S T L EL R + VH A + ++ ++E+C RL +
Sbjct: 851 SQTC------------LPELLRFLGQNVH----ARKNKNVDILWQAAEICRRLNGVRFTS 894
Query: 1583 CGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNL 1634
C + R+ +SV+LEQ IL HG+ P+ QA + MR +G R E KN+
Sbjct: 895 CKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNV 946
Score = 32.7 bits (73), Expect = 3.0
Identities = 32/124 (25%), Positives = 51/124 (41%), Gaps = 10/124 (8%)
Query: 856 VYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMP 915
+Y + +T G +LE++ E + + ++ D+ V L LS ++
Sbjct: 232 MYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESL- 290
Query: 916 HFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHIN 975
R T+ ++I I YQE L P FK + L+ L+F PTN HI
Sbjct: 291 ----RRQIVTQYQTI---ILTYQENLTDLHQYRGPSFKASSLKADKK--LEFVPTNLHIQ 341
Query: 976 LMEV 979
M V
Sbjct: 342 RMRV 345
>gi|4504705 inositol polyphosphate-4-phosphatase, type 1 isoform b
[Homo sapiens]
Length = 954
Score = 120 bits (300), Expect = 1e-26
Identities = 101/352 (28%), Positives = 156/352 (44%), Gaps = 45/352 (12%)
Query: 1289 IKTLVDNIQRYVEDGKNQLLLALLK------CTDTELQLRRDAIFCQALVAAVCTFSEQL 1342
+ TL D + + K ++ L++ T LQ RRD +FCQ L A +C F +L
Sbjct: 595 LTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKL 654
Query: 1343 LAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVT 1402
L +++G +L Q+ G+L +SLLS T EE MLED+ +
Sbjct: 655 RNCL----HDDG------------FLRQLYTIGLLAQFESLLS--TYGEELAMLEDMSLG 696
Query: 1403 LSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLR 1462
+ +L NVTF Q + A+ ++ I G+R V L F LP ++ G LR
Sbjct: 697 IMDLRNVTFKVTQATSS--ASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLR 754
Query: 1463 LHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDA 1522
+ LF + + L + LQ+ IN +SL ++ Y+ + + L LP
Sbjct: 755 VQPVLFNVGINEQQTLAERFGDTS--LQEVINVESLVRLNSYFEQFKEV-LPEDCLPRSR 811
Query: 1523 STTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSVGAGLIPISSELCYRLGACQMVM 1582
S T L EL R + VH A + ++ ++E+C RL +
Sbjct: 812 SQTC------------LPELLRFLGQNVH----ARKNKNVDILWQAAEICRRLNGVRFTS 855
Query: 1583 CGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNL 1634
C + R+ +SV+LEQ IL HG+ P+ QA + MR G R + KNL
Sbjct: 856 CKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSIGTREVVTQKNL 907
Score = 32.7 bits (73), Expect = 3.0
Identities = 32/124 (25%), Positives = 51/124 (41%), Gaps = 10/124 (8%)
Query: 856 VYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMP 915
+Y + +T G +LE++ E + + ++ D+ V L LS ++
Sbjct: 232 MYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESL- 290
Query: 916 HFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHIN 975
R T+ ++I I YQE L P FK + L+ L+F PTN HI
Sbjct: 291 ----RRQIVTQYQTI---ILTYQENLTDLHQYRGPSFKASSLKADKK--LEFVPTNLHIQ 341
Query: 976 LMEV 979
M V
Sbjct: 342 RMRV 345
>gi|4755140 inositol polyphosphate-4-phosphatase, type 1 isoform a
[Homo sapiens]
Length = 938
Score = 120 bits (300), Expect = 1e-26
Identities = 101/352 (28%), Positives = 157/352 (44%), Gaps = 45/352 (12%)
Query: 1289 IKTLVDNIQRYVEDGKNQLLLALLK------CTDTELQLRRDAIFCQALVAAVCTFSEQL 1342
+ TL D + + K ++ L++ T LQ RRD +FCQ L A +C F +L
Sbjct: 595 LTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKL 654
Query: 1343 LAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVT 1402
L +++G +L Q+ G+L +SLLS T EE MLED+ +
Sbjct: 655 RNCL----HDDG------------FLRQLYTIGLLAQFESLLS--TYGEELAMLEDMSLG 696
Query: 1403 LSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLR 1462
+ +L NVTF Q + A+ ++ I G+R V L F LP ++ G LR
Sbjct: 697 IMDLRNVTFKVTQATSS--ASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLR 754
Query: 1463 LHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDA 1522
+ LF + + L + LQ+ IN +SL ++ Y+ + + L LP
Sbjct: 755 VQPVLFNVGINEQQTLAERFGDTS--LQEVINVESLVRLNSYFEQFKEV-LPEDCLPRSR 811
Query: 1523 STTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSVGAGLIPISSELCYRLGACQMVM 1582
S T L EL R + VH A + ++ ++E+C RL +
Sbjct: 812 SQTC------------LPELLRFLGQNVH----ARKNKNVDILWQAAEICRRLNGVRFTS 855
Query: 1583 CGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNL 1634
C + R+ +SV+LEQ IL HG+ P+ QA + MR +G R E KN+
Sbjct: 856 CKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNV 907
Score = 32.7 bits (73), Expect = 3.0
Identities = 32/124 (25%), Positives = 51/124 (41%), Gaps = 10/124 (8%)
Query: 856 VYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMP 915
+Y + +T G +LE++ E + + ++ D+ V L LS ++
Sbjct: 232 MYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESL- 290
Query: 916 HFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHIN 975
R T+ ++I I YQE L P FK + L+ L+F PTN HI
Sbjct: 291 ----RRQIVTQYQTI---ILTYQENLTDLHQYRGPSFKASSLKADKK--LEFVPTNLHIQ 341
Query: 976 LMEV 979
M V
Sbjct: 342 RMRV 345
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 117 bits (293), Expect = 9e-26
Identities = 104/326 (31%), Positives = 147/326 (45%), Gaps = 39/326 (11%)
Query: 3 APSGSEPGGDGA----------GDCAHPDPRAPGAAAPSSGPGPCAAAR-------ESER 45
AP+ + P G G+ GD A A A+ P PGP S R
Sbjct: 40 APTMASPRGSGSSTSLSTVGSEGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSAR 99
Query: 46 QLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIED 105
RL V EI+ TER YV LR + +L + D GL+ E V LF+NIED
Sbjct: 100 PSRLER-VAREIVETERAYVRDLRSIVEDYLGPL----LDGGVLGLSVEQVGTLFANIED 154
Query: 106 ILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKI 165
I E + L LE S + F++ + F +Y YC N+ +L LL EL+
Sbjct: 155 IYEFSSELLEDLE-----NSSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLS 209
Query: 166 PTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAK---RTPGKHPDHPA 222
P +L + +PL+ +LL P+QRI KY LLL+EL K PG
Sbjct: 210 PPAALWLQERQ---AQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGT-GGREM 265
Query: 223 VQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKIS 282
V+ A+ +M V IN+ KR+ E L+++Q + GW G L+ +L+L+G
Sbjct: 266 VEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAF-GELVLEGAFRGGG 324
Query: 283 AGNIQ----ERAFFLFDNLLVYCKRK 304
G + ER FLF +L+ KR+
Sbjct: 325 GGGPRLRGGERLLFLFSRMLLVAKRR 350
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 117 bits (292), Expect = 1e-25
Identities = 115/410 (28%), Positives = 193/410 (47%), Gaps = 48/410 (11%)
Query: 19 HPDPRAPGAAAPSSGPGP-CAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLH 77
+P ++P +P GP A R+ +LR V+ E+L TER YV L L +L
Sbjct: 1013 NPSDQSP---SPQDSTGPQLATMRQLSDADKLRK-VICELLETERTYVKDLNCLMERYLK 1068
Query: 78 RIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQH-------- 129
+++ E LT++ + VLF N+ +++E +FL LE + P +
Sbjct: 1069 PLQK------ETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFK 1122
Query: 130 ----ELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTD 185
LG FL + D+F +Y +C++H K ++LV+ +AFL + ++
Sbjct: 1123 KVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDA---QNPKQQHS 1179
Query: 186 IPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQME 245
LE YL+ PIQRI KYPLLL+EL T + +H + A++ M V S+INE ++ E
Sbjct: 1180 STLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHE 1239
Query: 246 KLEAL-EQLQSHIEGWEGSNLTDICT-QLLLQGTLLKI----SAGNIQ---ERAFFLFDN 296
+ A+ +QL + G E + D+ LLL T++ + S G + E A F+F
Sbjct: 1240 EFGAVFDQLIAEQTG-EKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKT 1298
Query: 297 LLVYCKRKSRVTGSKKSTKRTKSINGSLY------IFRGRINTEVMEVENVEDGTADYHS 350
+V + GSK+ K S S+Y FR I TE ++V + A+ ++
Sbjct: 1299 AVVLVYK----DGSKQKKKLVGSHRLSIYEDWDPFRFRHMIPTEALQVRALASADAEANA 1354
Query: 351 NGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQ--KWLDAIIREREQRESLK 398
V + + + +C + K K + +I+R++ +R+ LK
Sbjct: 1355 VCEIVHVKSESEGRPERVFHLCCSSPESRKDFLKAVHSILRDKHRRQLLK 1404
>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 112 bits (281), Expect = 2e-24
Identities = 89/343 (25%), Positives = 159/343 (46%), Gaps = 43/343 (12%)
Query: 51 LCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVH 110
L + E+L TE YV L L F R+ + G+ E + +FSNI I H
Sbjct: 159 LHIAQELLHTEETYVKRLHLLDQVFCTRL-------TDAGIPPEVIMGIFSNISSIHRFH 211
Query: 111 KDFLAA-LEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVR 169
FL L+ + E + LG++ K +Y EY N ++A+ L+ T R
Sbjct: 212 GQFLLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTW----TQR 267
Query: 170 AFLLSCMLLGGRKTT---DIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSA 226
+ L ++ +K ++ L+ ++L P+QR+ +Y LLLK+ KR P PD + +
Sbjct: 268 SPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERS 327
Query: 227 LQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISA--G 284
L+ + T ++ N R++EK+ L ++ + G E ++ + +L+ +G + K+SA G
Sbjct: 328 LELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEE--DIVNPANELIKEGQIQKLSAKNG 385
Query: 285 NIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDG 344
Q+R FLF+++++YC K R+ G K S + I+G V+D
Sbjct: 386 TPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMDISGL----------------QVQDI 429
Query: 345 TADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAI 387
++ + + T + + +T EEK++W+ I
Sbjct: 430 VKPNTAHTFII--------TGRKRSLELQTRTEEEKKEWIQII 464
>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 112 bits (281), Expect = 2e-24
Identities = 89/343 (25%), Positives = 159/343 (46%), Gaps = 43/343 (12%)
Query: 51 LCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVH 110
L + E+L TE YV L L F R+ + G+ E + +FSNI I H
Sbjct: 159 LHIAQELLHTEETYVKRLHLLDQVFCTRL-------TDAGIPPEVIMGIFSNISSIHRFH 211
Query: 111 KDFLAA-LEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVR 169
FL L+ + E + LG++ K +Y EY N ++A+ L+ T R
Sbjct: 212 GQFLLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTW----TQR 267
Query: 170 AFLLSCMLLGGRKTT---DIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSA 226
+ L ++ +K ++ L+ ++L P+QR+ +Y LLLK+ KR P PD + +
Sbjct: 268 SPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERS 327
Query: 227 LQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISA--G 284
L+ + T ++ N R++EK+ L ++ + G E ++ + +L+ +G + K+SA G
Sbjct: 328 LELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEE--DIVNPANELIKEGQIQKLSAKNG 385
Query: 285 NIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDG 344
Q+R FLF+++++YC K R+ G K S + I+G V+D
Sbjct: 386 TPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMDISGL----------------QVQDI 429
Query: 345 TADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAI 387
++ + + T + + +T EEK++W+ I
Sbjct: 430 VKPNTAHTFII--------TGRKRSLELQTRTEEEKKEWIQII 464
>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
sapiens]
Length = 2063
Score = 112 bits (280), Expect = 3e-24
Identities = 89/302 (29%), Positives = 152/302 (50%), Gaps = 26/302 (8%)
Query: 21 DPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIR 80
+ + P AA P+ P P + S+ Q+ +R V +L TE+ YV +LR L ++ ++
Sbjct: 1039 EAKPPEAARPADEPTPASKCC-SKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLK 1097
Query: 81 QNVADSV-EKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFK 139
Q + + L +E +F I ++LE H+ FL + +C+ +Q ++G + ++
Sbjct: 1098 QPENSVLCDPSLVDE----IFDQIPELLEHHEQFLEQVRHCMQTW-HAQQKVGALLVQSF 1152
Query: 140 DK------FCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLL 193
K + Y + N + A+R+ E P FL M K L ++
Sbjct: 1153 SKDVLVNIYSAYIDNFLNAKDAVRVAKEAR--PAFLKFLEQSMRENKEKQA---LSDLMI 1207
Query: 194 SPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLE----A 249
P+QRI +Y LL+K+L K TP HPDHP + A + +K V IN+ R E+ E
Sbjct: 1208 KPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARV 1267
Query: 250 LEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISA-GNIQERAFFLFDNLLVYCKRKSRVT 308
L+++++HIEG E +L + L Q ++++ A G ++R+ FLF +L+V C R +
Sbjct: 1268 LQEIEAHIEGME--DLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIV-CTTLKRKS 1324
Query: 309 GS 310
GS
Sbjct: 1325 GS 1326
>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
Length = 655
Score = 111 bits (278), Expect = 5e-24
Identities = 93/346 (26%), Positives = 154/346 (44%), Gaps = 33/346 (9%)
Query: 53 VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112
++ E+L TE+ YV L L F + + S K E+ V+V+FSNI I + H
Sbjct: 106 IVQELLETEQAYVARLHLLDQVFFQELLKTARSS--KAFPEDVVRVIFSNISSIYQFHSQ 163
Query: 113 FLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVE-LNKIPTVRAF 171
F + + +G+V K +Y EY N E+A LL +K P +
Sbjct: 164 FFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEV 223
Query: 172 LLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMK 231
L + + + L+ ++L P+QRI +Y LLLKE ++ P + PD Q AL +
Sbjct: 224 LTR--IQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIF 281
Query: 232 TVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKIS--AGNIQER 289
+ + N +ME+L+ L ++ + G E ++ D LL +G +LKIS + ER
Sbjct: 282 SAAQHSNAAITEMERLQDLWEVYQRL-GLE-DDIVDPSNTLLREGPVLKISFRRNDPMER 339
Query: 290 AFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYH 349
FLF+N+L+YC + G++ + R RI+ M+V + D
Sbjct: 340 YLFLFNNMLLYCVPRVIQVGAQ-------------FQVRTRIDVAGMKVRELMDAE---F 383
Query: 350 SNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRE 395
+ + V + K + A++ EE W+ A +Q E
Sbjct: 384 PHSFLV--------SGKQRTLELQARSQEEMISWMQAFQAAIDQIE 421
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 111 bits (277), Expect = 7e-24
Identities = 92/386 (23%), Positives = 181/386 (46%), Gaps = 42/386 (10%)
Query: 53 VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112
+ NE+L TER YV L L F ++ + ++ E V +FSNI I H
Sbjct: 210 IANELLLTERAYVNRLDLLDQVFYCKLLE---EANRGSFPAEMVNKIFSNISSINAFHSK 266
Query: 113 FLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELN-KIPTVRAF 171
FL E ++ +G++ K +Y EY + A+ L+ + +IP ++
Sbjct: 267 FLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSV 326
Query: 172 LLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMK 231
+ + + + L+ ++L P+QRI +Y +LLK+ ++ P D + +L+ +
Sbjct: 327 VEE--IQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIIS 384
Query: 232 TVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGN--IQER 289
T S+ N R+ME L+ L ++ + E ++ + +L+ +G +LK++A N QER
Sbjct: 385 TAASHSNSAIRKMENLKKLLEIYEML--GEEEDIVNPSNELIKEGQILKLAARNTSAQER 442
Query: 290 AFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYH 349
FLF+N+L+YC K + GSK + + I+G +++E +N E +
Sbjct: 443 YLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDG----------MKIVETQNEE------Y 486
Query: 350 SNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIRE----REQRESLKLGMERD- 404
+ + V + K + A +A++K++W+ A+ ++ E+ + + +D
Sbjct: 487 PHTFQV--------SGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDN 538
Query: 405 ---AYVMIAEKGEKLYHMMMNKKVNL 427
+ V AE G++ + + +V +
Sbjct: 539 DIHSEVSTAELGKRAPRWIRDNEVTM 564
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 109 bits (272), Expect = 3e-23
Identities = 97/341 (28%), Positives = 159/341 (46%), Gaps = 39/341 (11%)
Query: 50 RLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEV 109
R C L EI TE Y TL ++ ++ +R L+ ++ +F N+ED+++V
Sbjct: 199 RNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLV--------LSPADMAAVFINLEDLIKV 250
Query: 110 HKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVEL-NKIPTV 168
H FL A++ + + L VFL FK++ +Y EYCS+ E A L +L
Sbjct: 251 HHSFLRAIDVSVMVGGST---LAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDF 307
Query: 169 RAFLLSCMLLGGRKTTD--IPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSA 226
R + C L K D L+ L+ P+QR+ KY LLLKEL + + P+ ++ A
Sbjct: 308 RQKVEECTL----KVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHS-AERPERQQLKEA 362
Query: 227 LQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGN- 285
L+AM+ + INE KR E L + + QS IE + + + + G L S N
Sbjct: 363 LEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNH 420
Query: 286 -IQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDG 344
Q+R FLFD +++ CKRK + + + + ++ + M ++V+
Sbjct: 421 TKQDRYLFLFDKVVIVCKRKG----------YSYELKEIIELLFHKMTDDPMNNKDVKKS 470
Query: 345 TADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLD 385
S G+ + IH K + F KT + K+KW++
Sbjct: 471 HGKMWSYGF-----YLIHLQGK-QGFQFFCKTEDMKRKWME 505
>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
Length = 961
Score = 108 bits (269), Expect = 6e-23
Identities = 94/356 (26%), Positives = 162/356 (45%), Gaps = 41/356 (11%)
Query: 53 VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112
+ NE+L TE+ YV L L F R+ + + + V +FSNI I H+
Sbjct: 377 IANELLQTEKAYVSRLHLLDQVFCARLLEEARN--RSSFPADVVHGIFSNICSIYCFHQQ 434
Query: 113 FLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFL 172
FL E +G++ K +Y EY N ++A VEL T R+
Sbjct: 435 FLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRA----VELVNTWTERSTQ 490
Query: 173 LSCMLLGGRKTT---DIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQA 229
++ +K ++ L+ ++L P+QRI +Y LLLK+ + P PD Q +L+
Sbjct: 491 FKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLEL 550
Query: 230 MKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISA--GNIQ 287
+ T + N R+ME++ L ++ + G E ++ +L+ +G +LK+SA G Q
Sbjct: 551 IATAAEHSNAAIRKMERMHKLLKVYELLGGEE--DIVSPTKELIKEGHILKLSAKNGTTQ 608
Query: 288 ERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTAD 347
+R LF++ L+YC + R+ G K S R RI+ + ME++
Sbjct: 609 DRYLILFNDRLLYCVPRLRLLGQKFSV-------------RARIDVDGMELK-------- 647
Query: 348 YHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAI----IREREQRESLKL 399
S+ + + + + K + A+T EEK+ W+ AI ++ + E+ KL
Sbjct: 648 -ESSNLNLPRTFLV--SGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKL 700
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 106 bits (265), Expect = 2e-22
Identities = 84/260 (32%), Positives = 129/260 (49%), Gaps = 23/260 (8%)
Query: 50 RLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEV 109
R C L EI TE Y TL ++ ++ +R L+ ++ +F N+ED+++V
Sbjct: 194 RNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLV--------LSPADMAAVFINLEDLIKV 245
Query: 110 HKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVEL-NKIPTV 168
H FL A++ + + L VFL FK++ +Y EYCS+ E A L +L
Sbjct: 246 HHSFLRAIDVSVMVGGST---LAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDF 302
Query: 169 RAFLLSCMLLGGRKTTD--IPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSA 226
R + C L K D L+ L+ P+QR+ KY LLLKEL + + P+ ++ A
Sbjct: 303 RQKVEECTL----KVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHS-AERPERQQLKEA 357
Query: 227 LQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGN- 285
L+AM+ + INE KR E L + + QS IE + + + + G L S N
Sbjct: 358 LEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNH 415
Query: 286 -IQERAFFLFDNLLVYCKRK 304
Q+R FLFD +++ CKRK
Sbjct: 416 TKQDRYLFLFDKVVIVCKRK 435
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 105 bits (263), Expect = 3e-22
Identities = 108/403 (26%), Positives = 178/403 (44%), Gaps = 41/403 (10%)
Query: 21 DPRAPGAAAP--SSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHR 78
D +A G P + P P AR RLR V+ E++ TE+ YV L L +L
Sbjct: 1070 DSQANGMEGPRENQDPPPRPLARHLSDADRLRK-VIQELVDTEKSYVKDLSCLFELYLEP 1128
Query: 79 IRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHP-------EPQSQHE- 130
++ E LT++ ++ LF ++ ++LE K FL LE + E SQ
Sbjct: 1129 LQN------ETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRK 1182
Query: 131 ----LGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDI 186
LG FL + D F +Y +C+NH K ++L +AFL + K
Sbjct: 1183 LLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDA---RNPTKQHSS 1239
Query: 187 PLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEK 246
LE YL+ P+QR+ KYPLLLKEL T + +H + AL+AM+ V S+INE ++ E
Sbjct: 1240 TLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYED 1299
Query: 247 L-EALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKIS-------AGNIQERAFFLFDN-- 296
+QL + G E +LL+ T+ ++ A E F+F
Sbjct: 1300 YGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAV 1359
Query: 297 LLVY---CKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGY 353
+LVY CK K ++ + + + ++ + FR I ++V + +S
Sbjct: 1360 ILVYKENCKLKKKLPSNSRPAHNSTDLDP--FKFRWLIPISALQVRLGNPAGTENNSIWE 1417
Query: 354 TVTNGWKIHNTAKNKWFVCMAKTAEEKQ--KWLDAIIREREQR 394
+ +I + + +C + + + K + +I+RE +R
Sbjct: 1418 LIHTKSEIEGRPETIFQLCCSDSESKTNIVKVIRSILRENFRR 1460
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 104 bits (259), Expect = 8e-22
Identities = 88/338 (26%), Positives = 149/338 (44%), Gaps = 37/338 (10%)
Query: 50 RLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEV 109
R C L EI TE Y TL +Q FL + ++ L ++++++F NIED+L V
Sbjct: 195 RCCCLREIQQTEEKYTDTLGSIQQHFLKPL--------QRFLKPQDIEIIFINIEDLLRV 246
Query: 110 HKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVR 169
H FL ++ L + L VF+K+K++F VY YCS E A + L+++ R
Sbjct: 247 HTHFLKEMKEALGTPGAA--NLYQVFIKYKERFLVYGRYCSQVESASK---HLDRVAAAR 301
Query: 170 AFLLSCMLLGGRKTTD--IPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSAL 227
+ + ++ + L L+ P+QR+ KY LLL+EL K T + + ++ AL
Sbjct: 302 EDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQ-EAMEKENLRLAL 360
Query: 228 QAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQ 287
AM+ + +NE KR E L + Q IE + S ++ + + + +
Sbjct: 361 DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM 420
Query: 288 ERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTAD 347
+R FL D L+ CKR+ G Y + +N +V + G D
Sbjct: 421 DRYAFLLDKALLICKRR-----------------GDSYDLKDFVNLHSFQVRDDSSGDRD 463
Query: 348 YHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLD 385
+ + + + + KT E K+KW++
Sbjct: 464 NKKWSHM----FLLIEDQGAQGYELFFKTRELKKKWME 497
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
[Homo sapiens]
Length = 626
Score = 103 bits (257), Expect = 1e-21
Identities = 104/388 (26%), Positives = 172/388 (44%), Gaps = 39/388 (10%)
Query: 34 PGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTE 93
P P AR RLR V+ E++ TE+ YV L L +L ++ E LT+
Sbjct: 10 PPPRPLARHLSDADRLRK-VIQELVDTEKSYVKDLSCLFELYLEPLQN------ETFLTQ 62
Query: 94 ENVKVLFSNIEDILEVHKDFLAALEYCLHP-------EPQSQHE-----LGNVFLKFKDK 141
+ ++ LF ++ ++LE K FL LE + E SQ LG FL + D
Sbjct: 63 DEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADH 122
Query: 142 FCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICK 201
F +Y +C+NH K ++L +AFL + K LE YL+ P+QR+ K
Sbjct: 123 FKLYSGFCANHIKVQKVLERAKTDKAFKAFLDA---RNPTKQHSSTLESYLIKPVQRVLK 179
Query: 202 YPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKL-EALEQLQSHIEGW 260
YPLLLKEL T + +H + AL+AM+ V S+INE ++ E +QL + G
Sbjct: 180 YPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGT 239
Query: 261 EGSNLTDICTQLLLQGTLLKIS-------AGNIQERAFFLFDN--LLVY---CKRKSRVT 308
E +LL+ T+ ++ A E F+F +LVY CK K ++
Sbjct: 240 EKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLP 299
Query: 309 GSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNK 368
+ + + ++ + FR I ++V + +S + +I +
Sbjct: 300 SNSRPAHNSTDLDP--FKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETI 357
Query: 369 WFVCMAKTAEEKQ--KWLDAIIREREQR 394
+ +C + + + K + +I+RE +R
Sbjct: 358 FQLCCSDSESKTNIVKVIRSILRENFRR 385
>gi|83715966 hypothetical protein LOC389337 [Homo sapiens]
Length = 675
Score = 103 bits (256), Expect = 2e-21
Identities = 86/278 (30%), Positives = 139/278 (50%), Gaps = 16/278 (5%)
Query: 26 GAAAPSSGPG-PCAAARESE-RQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNV 83
GA PSS G P R SE R L + + E++ TE Y+ L+ S R++Q
Sbjct: 5 GADEPSSRSGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQQ-- 62
Query: 84 ADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKF- 142
L + ++ VLFSNI+DI++V+ FL L+ E + +GN+FL+F+++
Sbjct: 63 -------LPQGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELE 115
Query: 143 CVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKY 202
VY+ YC+++++AL L+ K P ++ + + + L L+ P+QRI +Y
Sbjct: 116 QVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRY 175
Query: 203 PLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQME---KLEALEQLQSHIEG 259
PLLL+++ + T +P +Q A+ A++ V +NINE K + E K +EQL E
Sbjct: 176 PLLLQKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVEQLTLR-ER 234
Query: 260 WEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNL 297
N + + LLK AG I FD+L
Sbjct: 235 LARINTHTLSKKTTRLSQLLKQEAGLIPRTEDKEFDDL 272
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 100 bits (249), Expect = 1e-20
Identities = 72/224 (32%), Positives = 111/224 (49%), Gaps = 25/224 (11%)
Query: 29 APSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVE 88
APS G +A +R L R V+ E+L TERDY+ L + ++Q +++
Sbjct: 767 APS---GSVSAENPEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNID 823
Query: 89 KGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKF-CVYEE 147
+ LF N++ +++V K LAALE +G VFL +D+ Y+
Sbjct: 824 -------FEGLFGNMQMVIKVSKQLLAALEI--------SDAVGPVFLGHRDELEGTYKI 868
Query: 148 YCSNHEKALRLLVELNKIPTVRAFL------LSCMLLGGRKTTDIPLEGYLLSPIQRICK 201
YC NH++A+ LL K ++ L L + T I L +L+ P+QR+ +
Sbjct: 869 YCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMR 928
Query: 202 YPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQME 245
YPLLL EL TP HPD + +A+ A+K + NINE KR+ +
Sbjct: 929 YPLLLMELLNSTPESHPDKVPLTNAVLAVKEINVNINEYKRRKD 972
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 100 bits (249), Expect = 1e-20
Identities = 95/342 (27%), Positives = 155/342 (45%), Gaps = 46/342 (13%)
Query: 53 VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112
++ EIL TER Y+ L + F + + E + + +LFSNI+ I E H+
Sbjct: 539 IVKEILATERTYLKDLEVITVWFRSAVVK------EDAMPATLMTLLFSNIDPIYEFHRG 592
Query: 113 FLAALEY--CLHPEPQSQH------ELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNK 164
FL +E L P H +G++ L+ + + Y H++ +L EL K
Sbjct: 593 FLREVEQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDE---VLTELEK 649
Query: 165 IPTVRAFLLSCML--LGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPA 222
T R L + +K +PL +LL PIQR+ Y LLL+ L H D+
Sbjct: 650 A-TKRCKKLEAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYAD 708
Query: 223 VQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKIS 282
AL+A+ V + + ++E L+ L +LQ + G E NL + + +G L K++
Sbjct: 709 CHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIE--NLIAPGREFIREGCLHKLT 766
Query: 283 AGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVE 342
+Q+R FFLF ++L+Y + V G+ S + RG + + M VE +
Sbjct: 767 KKGLQQRMFFLFSDMLLYTSK--GVAGT------------SHFRIRGLLPLQGMLVEESD 812
Query: 343 DGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWL 384
N ++V + + I+ A K V A T EK+KW+
Sbjct: 813 --------NEWSVPHCFTIY--AAQKTIVVAASTRLEKEKWM 844
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 100 bits (248), Expect = 2e-20
Identities = 85/342 (24%), Positives = 148/342 (43%), Gaps = 46/342 (13%)
Query: 53 VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112
VL IL TE++Y L+ L +L ++ N L+ V L N E++ +
Sbjct: 245 VLQNILDTEKEYAKELQSLLVTYLRPLQSN------NNLSTVEVTSLLGNFEEVCTFQQT 298
Query: 113 FLAALEYCLHPEPQSQHELGNVFLKFKDKF-CVYEEYCSNHEKALRLLVELNKIPTVRAF 171
ALE C P++QH++G L F +Y YC+NH A+ +L + + + F
Sbjct: 299 LCQALEEC-SKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSD--ELEQF 355
Query: 172 LLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMK 231
+ + G + L L P R+ KY LL+EL + HPDH + A+ A K
Sbjct: 356 MEN---QGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFK 412
Query: 232 TVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISA-GNIQERA 290
T+ + R+ ++LE L+ L I+ WEG ++ ++ + + +++ A +ER
Sbjct: 413 TLMGQCQDL-RKRKQLE-LQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERY 470
Query: 291 FFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRI---NTEVMEVENVEDGTAD 347
LF N+L+ R++G +I++G+I T V ++ +E
Sbjct: 471 LMLFSNVLIMLSASPRMSG---------------FIYQGKIPIAGTVVTRLDEIEGNDCT 515
Query: 348 YHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIR 389
+ G TV V ++ Q+WL+ + R
Sbjct: 516 FEITGNTVER------------IVVHCNNNQDFQEWLEQLNR 545
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,476,545
Number of Sequences: 37866
Number of extensions: 2955706
Number of successful extensions: 11640
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 121
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 11080
Number of HSP's gapped (non-prelim): 378
length of query: 1659
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1543
effective length of database: 13,855,062
effective search space: 21378360666
effective search space used: 21378360666
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.