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Search of human proteins with 33624873
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33624873 spectrin repeat containing, nuclear envelope 2
isoform 4 [Homo sapiens]
(556 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33624873 spectrin repeat containing, nuclear envelope 2 isofo... 1121 0.0
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof... 1077 0.0
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof... 1026 0.0
gi|33624861 spectrin repeat containing, nuclear envelope 2 isofo... 847 0.0
gi|154277120 spectrin repeat containing, nuclear envelope 1 isof... 363 e-100
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 363 e-100
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof... 337 2e-92
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 337 2e-92
gi|145580592 nesprin-3 [Homo sapiens] 77 5e-14
gi|33188443 microfilament and actin filament cross-linker protei... 53 8e-07
gi|33188445 microfilament and actin filament cross-linker protei... 53 8e-07
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 50 5e-06
gi|221316624 dystonin isoform 4 [Homo sapiens] 49 2e-05
gi|221316622 dystonin isoform 3 [Homo sapiens] 49 2e-05
gi|221316618 dystonin isoform 2 [Homo sapiens] 49 2e-05
gi|34577047 dystonin isoform 1 [Homo sapiens] 49 2e-05
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 49 2e-05
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 48 3e-05
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 48 3e-05
gi|67782321 spectrin beta isoform a [Homo sapiens] 46 8e-05
gi|67782319 spectrin beta isoform b [Homo sapiens] 46 8e-05
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 46 8e-05
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 45 2e-04
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 44 3e-04
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 44 3e-04
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 43 9e-04
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 42 0.001
gi|24233517 IKK interacting protein isoform 1 [Homo sapiens] 42 0.001
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 42 0.001
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 41 0.003
>gi|33624873 spectrin repeat containing, nuclear envelope 2 isoform
4 [Homo sapiens]
Length = 556
Score = 1121 bits (2899), Expect = 0.0
Identities = 556/556 (100%), Positives = 556/556 (100%)
Query: 1 MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG 60
MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG
Sbjct: 1 MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG 60
Query: 61 GSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDSPSCP 120
GSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDSPSCP
Sbjct: 61 GSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDSPSCP 120
Query: 121 EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG 180
EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG
Sbjct: 121 EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG 180
Query: 181 ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP 240
ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP
Sbjct: 181 ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP 240
Query: 241 SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE 300
SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE
Sbjct: 241 SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE 300
Query: 301 AAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHV 360
AAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHV
Sbjct: 301 AAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHV 360
Query: 361 TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI 420
TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI
Sbjct: 361 TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI 420
Query: 421 EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTE 480
EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTE
Sbjct: 421 EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTE 480
Query: 481 GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA 540
GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA
Sbjct: 481 GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA 540
Query: 541 RSFYPMLRYTNGPPPT 556
RSFYPMLRYTNGPPPT
Sbjct: 541 RSFYPMLRYTNGPPPT 556
>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
[Homo sapiens]
Length = 6907
Score = 1077 bits (2785), Expect = 0.0
Identities = 541/556 (97%), Positives = 541/556 (97%), Gaps = 15/556 (2%)
Query: 1 MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG 60
MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG
Sbjct: 6367 MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG 6426
Query: 61 GSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDSPSCP 120
GSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDSPSCP
Sbjct: 6427 GSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDSPSCP 6486
Query: 121 EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG 180
EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG
Sbjct: 6487 EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG 6546
Query: 181 ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP 240
ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP
Sbjct: 6547 ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP 6606
Query: 241 SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE 300
SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE
Sbjct: 6607 SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE 6666
Query: 301 AAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHV 360
AAQGAVDSWRGGLRQSLMQCQ DFHQLSQNLLLWLASAKNRRQKAHV
Sbjct: 6667 AAQGAVDSWRGGLRQSLMQCQ--------------DFHQLSQNLLLWLASAKNRRQKAHV 6712
Query: 361 TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI 420
TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI
Sbjct: 6713 TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI 6772
Query: 421 EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTE 480
EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK FRAVRTTE
Sbjct: 6773 EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK-FRAVRTTE 6831
Query: 481 GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA 540
GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA
Sbjct: 6832 GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA 6891
Query: 541 RSFYPMLRYTNGPPPT 556
RSFYPMLRYTNGPPPT
Sbjct: 6892 RSFYPMLRYTNGPPPT 6907
Score = 40.8 bits (94), Expect = 0.003
Identities = 54/271 (19%), Positives = 108/271 (39%), Gaps = 21/271 (7%)
Query: 179 AGITEQQSGAFDRWEMIQAQELHNKLKIKQN---LQQLNSDISAITTWLKKTEAELEMLK 235
A I ++ + DRW+ + K+K+ +QQL+ ++S + TWL + E+EL
Sbjct: 5990 AEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSK-P 6048
Query: 236 MAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQL 295
+ D QEI+ R+ Q++ + + + A V SV L + E +
Sbjct: 6049 VVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANE-----TEC 6103
Query: 296 SLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRR 355
+ + + WR S+ + + R F D+ + WL SA+
Sbjct: 6104 DSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFED----WLKSAERT- 6158
Query: 356 QKAHVTDPKADPRALLECRRELMQLE---KELVERQPQVDMLQEISNSLLIKGHGEDCIE 412
P + + EL + E +++ ER Q++++ + L + +
Sbjct: 6159 ----AACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214
Query: 413 AEEKVHVIEKKLKQLREQVSQDLMALQGTQN 443
++ VH ++ L+ +V+ L L+ N
Sbjct: 6215 LKQMVHEGNQRWDNLQRRVTAVLRRLRHFTN 6245
Score = 35.0 bits (79), Expect = 0.18
Identities = 23/103 (22%), Positives = 40/103 (38%), Gaps = 2/103 (1%)
Query: 199 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLK--MAKPPSDIQEIELRVKRLQEI 256
ELH + ++L N D +T WL+ ++ L K D+ I + E
Sbjct: 4935 ELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEF 4994
Query: 257 LKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW 299
K D +L +V + L + ++ L++ L Q W
Sbjct: 4995 SKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKW 5037
Score = 30.4 bits (67), Expect = 4.4
Identities = 49/211 (23%), Positives = 84/211 (39%), Gaps = 31/211 (14%)
Query: 204 LKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAK----PPSDI--------QEIELRVK 251
LK K + +N + LK E L L+ AK P +D+ QE L VK
Sbjct: 1302 LKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVK 1361
Query: 252 RLQ-EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWR 310
+ EI D K L + + F E + T ++ L S+ G
Sbjct: 1362 NKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGY----- 1416
Query: 311 GGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRAL 370
G+++ ++ + FK+ LL + +++ K + DP A+
Sbjct: 1417 -GVQEEF-----TEENKLLEACIFKN-----NELLKNIQDVQSQISKIGLKDPTVP--AV 1463
Query: 371 LECRRELMQLEKELVERQPQVDMLQEISNSL 401
++ L++L+K L E + + LQE++NSL
Sbjct: 1464 KHRKKSLIRLDKVLDEYEEEKRHLQEMANSL 1494
>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
[Homo sapiens]
Length = 6885
Score = 1026 bits (2653), Expect = 0.0
Identities = 519/556 (93%), Positives = 519/556 (93%), Gaps = 37/556 (6%)
Query: 1 MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG 60
MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG
Sbjct: 6367 MEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG 6426
Query: 61 GSSSHEEDEEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDSPSCP 120
GSSSHEEDEEGPYYSALS GKSISDGHSWHVPDSPSCP
Sbjct: 6427 GSSSHEEDEEGPYYSALS-----------------------GKSISDGHSWHVPDSPSCP 6463
Query: 121 EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG 180
EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG
Sbjct: 6464 EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAG 6523
Query: 181 ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP 240
ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP
Sbjct: 6524 ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPP 6583
Query: 241 SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE 300
SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE
Sbjct: 6584 SDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWE 6643
Query: 301 AAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHV 360
AAQGAVDSWRGGLRQSLMQCQ DFHQLSQNLLLWLASAKNRRQKAHV
Sbjct: 6644 AAQGAVDSWRGGLRQSLMQCQ--------------DFHQLSQNLLLWLASAKNRRQKAHV 6689
Query: 361 TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI 420
TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI
Sbjct: 6690 TDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI 6749
Query: 421 EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTE 480
EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTE
Sbjct: 6750 EKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTE 6809
Query: 481 GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA 540
GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA
Sbjct: 6810 GEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFA 6869
Query: 541 RSFYPMLRYTNGPPPT 556
RSFYPMLRYTNGPPPT
Sbjct: 6870 RSFYPMLRYTNGPPPT 6885
Score = 40.8 bits (94), Expect = 0.003
Identities = 54/271 (19%), Positives = 108/271 (39%), Gaps = 21/271 (7%)
Query: 179 AGITEQQSGAFDRWEMIQAQELHNKLKIKQN---LQQLNSDISAITTWLKKTEAELEMLK 235
A I ++ + DRW+ + K+K+ +QQL+ ++S + TWL + E+EL
Sbjct: 5990 AEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSK-P 6048
Query: 236 MAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQL 295
+ D QEI+ R+ Q++ + + + A V SV L + E +
Sbjct: 6049 VVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANE-----TEC 6103
Query: 296 SLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRR 355
+ + + WR S+ + + R F D+ + WL SA+
Sbjct: 6104 DSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFED----WLKSAERT- 6158
Query: 356 QKAHVTDPKADPRALLECRRELMQLE---KELVERQPQVDMLQEISNSLLIKGHGEDCIE 412
P + + EL + E +++ ER Q++++ + L + +
Sbjct: 6159 ----AACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214
Query: 413 AEEKVHVIEKKLKQLREQVSQDLMALQGTQN 443
++ VH ++ L+ +V+ L L+ N
Sbjct: 6215 LKQMVHEGNQRWDNLQRRVTAVLRRLRHFTN 6245
Score = 35.0 bits (79), Expect = 0.18
Identities = 23/103 (22%), Positives = 40/103 (38%), Gaps = 2/103 (1%)
Query: 199 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLK--MAKPPSDIQEIELRVKRLQEI 256
ELH + ++L N D +T WL+ ++ L K D+ I + E
Sbjct: 4935 ELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEF 4994
Query: 257 LKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW 299
K D +L +V + L + ++ L++ L Q W
Sbjct: 4995 SKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKW 5037
Score = 30.4 bits (67), Expect = 4.4
Identities = 49/211 (23%), Positives = 84/211 (39%), Gaps = 31/211 (14%)
Query: 204 LKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAK----PPSDI--------QEIELRVK 251
LK K + +N + LK E L L+ AK P +D+ QE L VK
Sbjct: 1302 LKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVK 1361
Query: 252 RLQ-EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWR 310
+ EI D K L + + F E + T ++ L S+ G
Sbjct: 1362 NKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGY----- 1416
Query: 311 GGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRAL 370
G+++ ++ + FK+ LL + +++ K + DP A+
Sbjct: 1417 -GVQEEF-----TEENKLLEACIFKN-----NELLKNIQDVQSQISKIGLKDPTVP--AV 1463
Query: 371 LECRRELMQLEKELVERQPQVDMLQEISNSL 401
++ L++L+K L E + + LQE++NSL
Sbjct: 1464 KHRKKSLIRLDKVLDEYEEEKRHLQEMANSL 1494
>gi|33624861 spectrin repeat containing, nuclear envelope 2 isoform
2 [Homo sapiens]
Length = 429
Score = 847 bits (2187), Expect = 0.0
Identities = 429/430 (99%), Positives = 429/430 (99%), Gaps = 1/430 (0%)
Query: 127 MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS 186
MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS
Sbjct: 1 MEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQS 60
Query: 187 GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 246
GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI
Sbjct: 61 GAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 120
Query: 247 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 306
ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV
Sbjct: 121 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 180
Query: 307 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 366
DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD
Sbjct: 181 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 240
Query: 367 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 426
PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ
Sbjct: 241 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 300
Query: 427 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETE 486
LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK FRAVRTTEGEEETE
Sbjct: 301 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAK-FRAVRTTEGEEETE 359
Query: 487 SRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPM 546
SRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPM
Sbjct: 360 SRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPM 419
Query: 547 LRYTNGPPPT 556
LRYTNGPPPT
Sbjct: 420 LRYTNGPPPT 429
>gi|154277120 spectrin repeat containing, nuclear envelope 1 isoform
3 [Homo sapiens]
Length = 982
Score = 363 bits (932), Expect = e-100
Identities = 241/608 (39%), Positives = 330/608 (54%), Gaps = 70/608 (11%)
Query: 1 MEDPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHT 56
+ED + W R S +PSS SL ERSG +TP SVDSIPLEWDH
Sbjct: 391 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 450
Query: 57 GDVG-------GSSSHEEDEEGP----YYS----ALSDVEIPENPEAYLKMTTKTLKASS 101
D+ + EDEEG +Y LSDV IPE+PEAY+K+T +K +S
Sbjct: 451 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTS 510
Query: 102 GK-SISDGHSWHVPDSPSCPEHHYKQMEGD-RNVPPVPPASSTPYKPPYGKLLLPPGTDG 159
G S + + + +Q E R+ P P T YK G + L
Sbjct: 511 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYK---GYMKLLGECSS 567
Query: 160 GKEGPRVLNGNPQQEDGGLAGITE------QQSGAFDRWEMIQAQELHNKLKIKQNLQ-- 211
+ + L ++E+ L G Q +G DRWE++QAQ L +L++KQNLQ
Sbjct: 568 SIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKW 627
Query: 212 -QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSV 270
Q NSD+++I WL TE ELE L+ + +DIQ IEL++K+L+E+ KA D KA+++S+
Sbjct: 628 QQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSI 687
Query: 271 NVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSD 330
N+ S EF Q +S ES +LQ RL Q++ W+ ++ WRG L+ +LMQCQG
Sbjct: 688 NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG-------- 739
Query: 331 VLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQ 390
FH++S LLL L + R+ + D D L + ++LMQ++ EL+E Q +
Sbjct: 740 ------FHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLR 793
Query: 391 VDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVS------QDLMALQGTQNP 444
V LQ++S LL+ G DC+EA+EKVHVI +LK L ++VS + L+ + +Q
Sbjct: 794 VASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD 853
Query: 445 ASPLPSFDEVD-SGDQPPATSVPAP-RAKQFRA---------------VRTTEGEEETES 487
S S DE+D SG P + P R K R R+T+G ++
Sbjct: 854 LSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSL 913
Query: 488 RVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML 547
PG R R FL RV+RAALPLQLLLLLL+ LACL+P SEEDYSC +NNFARSF+PML
Sbjct: 914 SEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPML 973
Query: 548 RYTNGPPP 555
RYTNGPPP
Sbjct: 974 RYTNGPPP 981
Score = 36.2 bits (82), Expect = 0.081
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 190 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 242
DRW+ + K+K+ L QQL+ ++S++ TWL E+EL AKP +
Sbjct: 26 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 80
Query: 243 IQEIELRVKRLQEILKAFDTYKALVVSV 270
+EI+ ++ QE+ + + + V SV
Sbjct: 81 SEEIQRKLNEQQELQRDIEKHSTGVASV 108
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
[Homo sapiens]
Length = 8749
Score = 363 bits (932), Expect = e-100
Identities = 241/608 (39%), Positives = 330/608 (54%), Gaps = 70/608 (11%)
Query: 1 MEDPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHT 56
+ED + W R S +PSS SL ERSG +TP SVDSIPLEWDH
Sbjct: 8158 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8217
Query: 57 GDVG-------GSSSHEEDEEGP----YYS----ALSDVEIPENPEAYLKMTTKTLKASS 101
D+ + EDEEG +Y LSDV IPE+PEAY+K+T +K +S
Sbjct: 8218 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTS 8277
Query: 102 GK-SISDGHSWHVPDSPSCPEHHYKQMEGD-RNVPPVPPASSTPYKPPYGKLLLPPGTDG 159
G S + + + +Q E R+ P P T YK G + L
Sbjct: 8278 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYK---GYMKLLGECSS 8334
Query: 160 GKEGPRVLNGNPQQEDGGLAGITE------QQSGAFDRWEMIQAQELHNKLKIKQNLQ-- 211
+ + L ++E+ L G Q +G DRWE++QAQ L +L++KQNLQ
Sbjct: 8335 SIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKW 8394
Query: 212 -QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSV 270
Q NSD+++I WL TE ELE L+ + +DIQ IEL++K+L+E+ KA D KA+++S+
Sbjct: 8395 QQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSI 8454
Query: 271 NVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSD 330
N+ S EF Q +S ES +LQ RL Q++ W+ ++ WRG L+ +LMQCQG
Sbjct: 8455 NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG-------- 8506
Query: 331 VLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQ 390
FH++S LLL L + R+ + D D L + ++LMQ++ EL+E Q +
Sbjct: 8507 ------FHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLR 8560
Query: 391 VDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVS------QDLMALQGTQNP 444
V LQ++S LL+ G DC+EA+EKVHVI +LK L ++VS + L+ + +Q
Sbjct: 8561 VASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD 8620
Query: 445 ASPLPSFDEVD-SGDQPPATSVPAP-RAKQFRA---------------VRTTEGEEETES 487
S S DE+D SG P + P R K R R+T+G ++
Sbjct: 8621 LSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSL 8680
Query: 488 RVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML 547
PG R R FL RV+RAALPLQLLLLLL+ LACL+P SEEDYSC +NNFARSF+PML
Sbjct: 8681 SEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPML 8740
Query: 548 RYTNGPPP 555
RYTNGPPP
Sbjct: 8741 RYTNGPPP 8748
Score = 40.0 bits (92), Expect = 0.006
Identities = 59/295 (20%), Positives = 118/295 (40%), Gaps = 20/295 (6%)
Query: 157 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQ---AQELHNKLKIKQNLQQL 213
TD K P E G T + WE ++ +++ + + Q+
Sbjct: 5838 TDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKY 5897
Query: 214 NSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVS 273
+ +I+T ++ E LK+++ P + E ++ Q ++ + + + S
Sbjct: 5898 QDSLQSISTKMEAIE-----LKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 5952
Query: 274 SKEFLQTESPESTELQSRLRQLSLLWEAAQ-GAVDSWRGGLRQSLMQCQGSKTRPRSDVL 332
E L +ES E+ + Q +L A + + G RQ L + + +
Sbjct: 5953 LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ 6012
Query: 333 FFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 392
+ + + L WL S K A + + P+ ++ +LM + LVE + +V
Sbjct: 6013 ALQRYRCEADELDSWLLSTK-----ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 6067
Query: 393 MLQEIS---NSLLIKGHGEDCIEAEE---KVHVIEKKLKQLREQVSQDLMALQGT 441
L E+S +LL++G EAE+ K+ ++ L +L+ + + +QGT
Sbjct: 6068 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGT 6122
Score = 36.2 bits (82), Expect = 0.081
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 190 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 242
DRW+ + K+K+ L QQL+ ++S++ TWL E+EL AKP +
Sbjct: 7793 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 7847
Query: 243 IQEIELRVKRLQEILKAFDTYKALVVSV 270
+EI+ ++ QE+ + + + V SV
Sbjct: 7848 SEEIQRKLNEQQELQRDIEKHSTGVASV 7875
Score = 32.7 bits (73), Expect = 0.90
Identities = 25/117 (21%), Positives = 53/117 (45%), Gaps = 6/117 (5%)
Query: 206 IKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA 265
+K S+ ++ W+ + E EL L+ + D+Q +++V +QEI ++ +
Sbjct: 1451 VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKV-TIQEI----ESKLS 1505
Query: 266 LVVSVNVSSKEFLQ-TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQ 321
+V + ++ F Q + ES ++++L Q+ E + G + L Q Q
Sbjct: 1506 SIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQ 1562
Score = 32.3 bits (72), Expect = 1.2
Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 196 QAQELHNKLKIK-QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR--VKR 252
+ +EL +KI+ QNLQ D+ LKK +A LE + ++ + L+ +
Sbjct: 5541 ETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH 5600
Query: 253 LQEILKAFDTYKALVVSVNV 272
Q +L ++ K V +V +
Sbjct: 5601 RQHLLSEMESLKPKVQAVQL 5620
Score = 30.4 bits (67), Expect = 4.4
Identities = 47/220 (21%), Positives = 88/220 (40%), Gaps = 26/220 (11%)
Query: 226 KTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPES 285
K + E + + S QE E ++L+ LK+ ++ V + ++E L+ +
Sbjct: 4692 KRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLA 4751
Query: 286 TELQS----------RLRQLS-----LLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSD 330
LQ L L+ L +E A+ + SW+G L+ + T S
Sbjct: 4752 GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESR 4811
Query: 331 VLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQ 390
++ DF L WL RR KA ++ P L + + E+ +++ E Q
Sbjct: 4812 MVQSIDFQTEMSRSLDWL-----RRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4866
Query: 391 VDMLQEISNSLLIKGHGEDCIEAEEKVHV-IEKKLKQLRE 429
+ ++ +S+ E +A+E + +E L +L E
Sbjct: 4867 LRIMNALSHK-----EKEKFTKAKELISADLEHSLAELSE 4901
>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
[Homo sapiens]
Length = 3321
Score = 337 bits (863), Expect = 2e-92
Identities = 228/594 (38%), Positives = 315/594 (53%), Gaps = 65/594 (10%)
Query: 1 MEDPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHT 56
+ED + W R S +PSS SL ERSG +TP SVDSIPLEWDH
Sbjct: 2753 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 2812
Query: 57 GDVGGSSSHEEDEEGPYYSAL--SDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVP 114
D+ D E AL D E ++ + YL+ + S S + +
Sbjct: 2813 YDLS------RDLESAMSRALPSEDEEGQDDKDFYLR---GAVGLSGDHSALESQIRQLG 2863
Query: 115 DSPSCPEHHYKQMEGD-RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQ 173
+ +Q E R+ P P T YK G + L + + L ++
Sbjct: 2864 KALDDSRFQIQQTENIIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKE 2920
Query: 174 EDGGLAGITE------QQSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWL 224
E+ L G Q +G DRWE++QAQ L +L++KQNLQ Q NSD+++I WL
Sbjct: 2921 EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 2980
Query: 225 KKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPE 284
TE ELE L+ + +DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S E
Sbjct: 2981 GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 3040
Query: 285 STELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNL 344
S +LQ RL Q++ W+ ++ WRG L+ +LMQCQG FH++S L
Sbjct: 3041 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG--------------FHEMSHGL 3086
Query: 345 LLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIK 404
LL L + R+ + D D L + ++LMQ++ EL+E Q +V LQ++S LL+
Sbjct: 3087 LLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN 3146
Query: 405 GHGEDCIEAEEKVHVIEKKLKQLREQVS------QDLMALQGTQNPASPLPSFDEVD-SG 457
G DC+EA+EKVHVI +LK L ++VS + L+ + +Q S S DE+D SG
Sbjct: 3147 AEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSG 3206
Query: 458 DQPPATSVPAP-RAKQFRA---------------VRTTEGEEETESRVPGSTRPQRSFLS 501
P + P R K R R+T+G ++ PG R R FL
Sbjct: 3207 SVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLF 3266
Query: 502 RVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 555
RV+RAALPLQLLLLLL+ LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 3267 RVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 3320
Score = 40.0 bits (92), Expect = 0.006
Identities = 59/295 (20%), Positives = 118/295 (40%), Gaps = 20/295 (6%)
Query: 157 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQ---AQELHNKLKIKQNLQQL 213
TD K P E G T + WE ++ +++ + + Q+
Sbjct: 433 TDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKY 492
Query: 214 NSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVS 273
+ +I+T ++ E LK+++ P + E ++ Q ++ + + + S
Sbjct: 493 QDSLQSISTKMEAIE-----LKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 547
Query: 274 SKEFLQTESPESTELQSRLRQLSLLWEAAQ-GAVDSWRGGLRQSLMQCQGSKTRPRSDVL 332
E L +ES E+ + Q +L A + + G RQ L + + +
Sbjct: 548 LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ 607
Query: 333 FFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 392
+ + + L WL S K A + + P+ ++ +LM + LVE + +V
Sbjct: 608 ALQRYRCEADELDSWLLSTK-----ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 662
Query: 393 MLQEIS---NSLLIKGHGEDCIEAEE---KVHVIEKKLKQLREQVSQDLMALQGT 441
L E+S +LL++G EAE+ K+ ++ L +L+ + + +QGT
Sbjct: 663 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGT 717
Score = 36.2 bits (82), Expect = 0.081
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 190 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 242
DRW+ + K+K+ L QQL+ ++S++ TWL E+EL AKP +
Sbjct: 2388 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 2442
Query: 243 IQEIELRVKRLQEILKAFDTYKALVVSV 270
+EI+ ++ QE+ + + + V SV
Sbjct: 2443 SEEIQRKLNEQQELQRDIEKHSTGVASV 2470
Score = 32.3 bits (72), Expect = 1.2
Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 196 QAQELHNKLKIK-QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR--VKR 252
+ +EL +KI+ QNLQ D+ LKK +A LE + ++ + L+ +
Sbjct: 136 ETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH 195
Query: 253 LQEILKAFDTYKALVVSVNV 272
Q +L ++ K V +V +
Sbjct: 196 RQHLLSEMESLKPKVQAVQL 215
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
[Homo sapiens]
Length = 8797
Score = 337 bits (863), Expect = 2e-92
Identities = 228/594 (38%), Positives = 315/594 (53%), Gaps = 65/594 (10%)
Query: 1 MEDPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHT 56
+ED + W R S +PSS SL ERSG +TP SVDSIPLEWDH
Sbjct: 8229 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8288
Query: 57 GDVGGSSSHEEDEEGPYYSAL--SDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVP 114
D+ D E AL D E ++ + YL+ + S S + +
Sbjct: 8289 YDLS------RDLESAMSRALPSEDEEGQDDKDFYLR---GAVGLSGDHSALESQIRQLG 8339
Query: 115 DSPSCPEHHYKQMEGD-RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQ 173
+ +Q E R+ P P T YK G + L + + L ++
Sbjct: 8340 KALDDSRFQIQQTENIIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKE 8396
Query: 174 EDGGLAGITE------QQSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWL 224
E+ L G Q +G DRWE++QAQ L +L++KQNLQ Q NSD+++I WL
Sbjct: 8397 EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 8456
Query: 225 KKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPE 284
TE ELE L+ + +DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S E
Sbjct: 8457 GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 8516
Query: 285 STELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNL 344
S +LQ RL Q++ W+ ++ WRG L+ +LMQCQG FH++S L
Sbjct: 8517 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG--------------FHEMSHGL 8562
Query: 345 LLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIK 404
LL L + R+ + D D L + ++LMQ++ EL+E Q +V LQ++S LL+
Sbjct: 8563 LLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN 8622
Query: 405 GHGEDCIEAEEKVHVIEKKLKQLREQVS------QDLMALQGTQNPASPLPSFDEVD-SG 457
G DC+EA+EKVHVI +LK L ++VS + L+ + +Q S S DE+D SG
Sbjct: 8623 AEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSG 8682
Query: 458 DQPPATSVPAP-RAKQFRA---------------VRTTEGEEETESRVPGSTRPQRSFLS 501
P + P R K R R+T+G ++ PG R R FL
Sbjct: 8683 SVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLF 8742
Query: 502 RVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 555
RV+RAALPLQLLLLLL+ LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 8743 RVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 8796
Score = 40.0 bits (92), Expect = 0.006
Identities = 59/295 (20%), Positives = 118/295 (40%), Gaps = 20/295 (6%)
Query: 157 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQ---AQELHNKLKIKQNLQQL 213
TD K P E G T + WE ++ +++ + + Q+
Sbjct: 5909 TDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKY 5968
Query: 214 NSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVS 273
+ +I+T ++ E LK+++ P + E ++ Q ++ + + + S
Sbjct: 5969 QDSLQSISTKMEAIE-----LKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 6023
Query: 274 SKEFLQTESPESTELQSRLRQLSLLWEAAQ-GAVDSWRGGLRQSLMQCQGSKTRPRSDVL 332
E L +ES E+ + Q +L A + + G RQ L + + +
Sbjct: 6024 LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ 6083
Query: 333 FFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 392
+ + + L WL S K A + + P+ ++ +LM + LVE + +V
Sbjct: 6084 ALQRYRCEADELDSWLLSTK-----ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 6138
Query: 393 MLQEIS---NSLLIKGHGEDCIEAEE---KVHVIEKKLKQLREQVSQDLMALQGT 441
L E+S +LL++G EAE+ K+ ++ L +L+ + + +QGT
Sbjct: 6139 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGT 6193
Score = 36.2 bits (82), Expect = 0.081
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 190 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 242
DRW+ + K+K+ L QQL+ ++S++ TWL E+EL AKP +
Sbjct: 7864 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 7918
Query: 243 IQEIELRVKRLQEILKAFDTYKALVVSV 270
+EI+ ++ QE+ + + + V SV
Sbjct: 7919 SEEIQRKLNEQQELQRDIEKHSTGVASV 7946
Score = 32.7 bits (73), Expect = 0.90
Identities = 25/117 (21%), Positives = 53/117 (45%), Gaps = 6/117 (5%)
Query: 206 IKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA 265
+K S+ ++ W+ + E EL L+ + D+Q +++V +QEI ++ +
Sbjct: 1444 VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKV-TIQEI----ESKLS 1498
Query: 266 LVVSVNVSSKEFLQ-TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQ 321
+V + ++ F Q + ES ++++L Q+ E + G + L Q Q
Sbjct: 1499 SIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQ 1555
Score = 32.3 bits (72), Expect = 1.2
Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 196 QAQELHNKLKIK-QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR--VKR 252
+ +EL +KI+ QNLQ D+ LKK +A LE + ++ + L+ +
Sbjct: 5612 ETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH 5671
Query: 253 LQEILKAFDTYKALVVSVNV 272
Q +L ++ K V +V +
Sbjct: 5672 RQHLLSEMESLKPKVQAVQL 5691
Score = 30.4 bits (67), Expect = 4.4
Identities = 47/220 (21%), Positives = 88/220 (40%), Gaps = 26/220 (11%)
Query: 226 KTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPES 285
K + E + + S QE E ++L+ LK+ ++ V + ++E L+ +
Sbjct: 4763 KRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLA 4822
Query: 286 TELQS----------RLRQLS-----LLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSD 330
LQ L L+ L +E A+ + SW+G L+ + T S
Sbjct: 4823 GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESR 4882
Query: 331 VLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQ 390
++ DF L WL RR KA ++ P L + + E+ +++ E Q
Sbjct: 4883 MVQSIDFQTEMSRSLDWL-----RRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4937
Query: 391 VDMLQEISNSLLIKGHGEDCIEAEEKVHV-IEKKLKQLRE 429
+ ++ +S+ E +A+E + +E L +L E
Sbjct: 4938 LRIMNALSHK-----EKEKFTKAKELISADLEHSLAELSE 4972
>gi|145580592 nesprin-3 [Homo sapiens]
Length = 975
Score = 76.6 bits (187), Expect = 5e-14
Identities = 98/361 (27%), Positives = 150/361 (41%), Gaps = 36/361 (9%)
Query: 205 KIKQNLQQ---LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 261
+ +Q++Q+ + + + W+ T +LE + P D + E +RL + F
Sbjct: 642 RCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERL---VAEFP 698
Query: 262 TYKALVVSVNVSSKEFLQTESPESTEL-QSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQC 320
+A + V ++ SPE + Q LR+L+ W A + +S +R +Q
Sbjct: 699 EKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQ- 757
Query: 321 QGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 380
R +V K + N + + +P DP R L+Q
Sbjct: 758 -------RMEVDSGKK-----------MVFTNNIPKSGFLINPM-DPIPRHRRRANLLQE 798
Query: 381 EKELVERQPQV----DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLM 436
E+ E Q+ ++ NS L++ AE+ + + KL++L +V +
Sbjct: 799 EEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAED-LRTRKSKLQELEARVPEGQH 857
Query: 437 ALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGE-EETESRVPGSTRP 495
+ + DE++ D + + K + T E T + R
Sbjct: 858 LFENLLRLGPARGTSDELE--DLRYQWMLYKSKLKDSGHLLTQSSPGEPTGFQKTRRWRG 915
Query: 496 QRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 555
S R ALPLQLLLLL LLL LLP EED SCT ANNFARSF MLRY NGPPP
Sbjct: 916 LGSLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSCTLANNFARSFTLMLRY-NGPPP 974
Query: 556 T 556
T
Sbjct: 975 T 975
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 52.8 bits (125), Expect = 8e-07
Identities = 61/272 (22%), Positives = 112/272 (41%), Gaps = 46/272 (16%)
Query: 192 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 247
WE + + H + K++ L Q + + +WL TE E+L +P S D + IE
Sbjct: 4748 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE---ELLDAQRPISGDPKVIE 4804
Query: 248 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 306
+ + + + ++A V +VN + E L++ + +++ L+SRL ++ WE+
Sbjct: 4805 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4864
Query: 307 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 366
+ L+ +L Q QG FH ++ LL L +++ + T
Sbjct: 4865 EEREQQLQSTLQQAQG--------------FHSEIEDFLLELTRMESQLSASKPTG---- 4906
Query: 367 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGH---------------GEDCI 411
L E RE + EL Q+ +E N LL KG +
Sbjct: 4907 --GLPETAREQLDTHMELYS---QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA 4961
Query: 412 EAEEKVHVIEKKLKQLREQVSQDLMALQGTQN 443
E+K HV+ K+++ + ++ + L QN
Sbjct: 4962 LLEQKWHVVSSKMEERKSKLEEALNLATEFQN 4993
Score = 48.1 bits (113), Expect = 2e-05
Identities = 56/248 (22%), Positives = 102/248 (41%), Gaps = 22/248 (8%)
Query: 208 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ--EILKAFDTYKA 265
Q QQ A W+ +T+ +L L + D +L+V++ +I++ D+
Sbjct: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 4274
Query: 266 LVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKT 325
L + S+ F + T LQ + L +EA SL+ +
Sbjct: 4275 LF---SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI-------------SLLNSERYAR 4318
Query: 326 RPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELV 385
R+ VL F + + L W+ + R A + P D L + + E+ QL + +
Sbjct: 4319 LERAQVLV-NQFWETYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIA 4375
Query: 386 ERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA 445
E +P +D L +I L + + E+ EEK E Q++E+V Q +AL + +
Sbjct: 4376 EHKPHIDKLLKIGPQLK-ELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQS 4434
Query: 446 SPLPSFDE 453
+ + F +
Sbjct: 4435 TQITEFHD 4442
Score = 45.8 bits (107), Expect = 1e-04
Identities = 74/351 (21%), Positives = 141/351 (40%), Gaps = 36/351 (10%)
Query: 181 ITEQQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLK-M 236
IT Q RW + ++ + +++ L +Q + I+ +L TE +L + +
Sbjct: 3858 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3917
Query: 237 AKPPSDIQEIELRVKRLQEILK--AFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 294
+ IQ+ +R K L+E ++ A D ++A+ + ++SS T E L ++
Sbjct: 3918 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL----TSPAEQGVLSEKIDS 3973
Query: 295 LSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNR 354
L + Q L Q+L + LF +D +L WLA +++
Sbjct: 3974 LQARYSEIQDRCCRKAALLDQALSNAR----------LFGED----EVEVLNWLAEVEDK 4019
Query: 355 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 414
V D K D L + + L +E+V R+ VD + +LL + GE+ + +
Sbjct: 4020 LSSVFVKDFKQD--VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQ 4077
Query: 415 EKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFR 474
EK+ I+ + + S+ L L+ + A+ S E +G
Sbjct: 4078 EKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVE----------E 4127
Query: 475 AVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLP 525
+ T+ G+ T ++P + Q+ V+ L L + + L L+P
Sbjct: 4128 ELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 4178
Score = 42.7 bits (99), Expect = 9e-04
Identities = 44/211 (20%), Positives = 92/211 (43%), Gaps = 21/211 (9%)
Query: 199 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILK 258
EL ++ LQ+ D +WL+++E ELE M K S + + +KR +
Sbjct: 2308 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELE--NMHKGGSSPETLPSLLKRQGSFSE 2365
Query: 259 AFDTYKALVVSVNVSSKEFLQTESP-----ESTELQSRLRQLSLLWEAAQGAVDSWRGGL 313
++K + V +S ++ L E+ E +E+ + ++ L +A +
Sbjct: 2366 DVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK--LKDATE---------- 2413
Query: 314 RQSLMQCQGSKTRPRSDVLF--FKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALL 371
R + + + ++ ++L + F + +L W+ + + +K +DP L
Sbjct: 2414 RYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQ 2473
Query: 372 ECRRELMQLEKELVERQPQVDMLQEISNSLL 402
E QL++EL E Q V+ LQ+++ ++
Sbjct: 2474 EQLATTKQLQEELAEHQVPVEKLQKVARDIM 2504
Score = 34.7 bits (78), Expect = 0.24
Identities = 65/322 (20%), Positives = 126/322 (39%), Gaps = 35/322 (10%)
Query: 194 MIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL 253
M++ + + L +K+ L+ LN +T K + +LE+ +++ ++K L
Sbjct: 3626 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL-----GRVEDFYRKLKGL 3680
Query: 254 QEILKAFDTYKAL-------VVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA--QG 304
+ A + +AL V +N +F + + LQ +L+Q++ L +
Sbjct: 3681 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSA 3740
Query: 305 AVDSWRGGLRQSLMQCQG------SKTRPR-----SDVLFFKDFHQLSQNLLLWLASAKN 353
D GL + + K R +L F + LL WLA +
Sbjct: 3741 GKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEE 3800
Query: 354 RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEA 413
A+ P A+ + + +E L++ L +R+ VDMLQ + D +
Sbjct: 3801 LI--ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3858
Query: 414 EEKVHVIEKKLKQL------REQVSQDLMAL-QGTQNPASPLPSFDEVDSGDQPPATSVP 466
++ +E + +L R++ +D++ L + A P+ F V + V
Sbjct: 3859 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3918
Query: 467 APRAK-QFRAVRTTEGEEETES 487
AK Q + +R EE+ E+
Sbjct: 3919 TQTAKIQQQIIRHKALEEDIEN 3940
Score = 32.0 bits (71), Expect = 1.5
Identities = 40/209 (19%), Positives = 88/209 (42%), Gaps = 19/209 (9%)
Query: 241 SDIQEIELRVKRLQEILKAFDTYKA----LVVSVNVSSKEFLQTESPESTELQSRLRQLS 296
+++Q++ + K L+ LK T + V + +S + + + ++ E ++ Q S
Sbjct: 1835 AELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKS 1894
Query: 297 LLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQ 356
L D+W L + KT+ + Q+L W+ + KN
Sbjct: 1895 L-----SSVSDTWNSRLLHFQNAVEIEKTKVLNQ---HTQLEGRLQDLRAWVGN-KNLIL 1945
Query: 357 KAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEK 416
+ ++ + D +L C ++ L++ + ER+ Q+D L I H +D + +
Sbjct: 1946 NSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDAL-AFDIQFFISEHAQDLSPQQNR 2004
Query: 417 -----VHVIEKKLKQLREQVSQDLMALQG 440
++ +++ + + EQ + + ALQG
Sbjct: 2005 QMLRLLNELQRSFQDILEQTAAQVDALQG 2033
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 52.8 bits (125), Expect = 8e-07
Identities = 61/272 (22%), Positives = 112/272 (41%), Gaps = 46/272 (16%)
Query: 192 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 247
WE + + H + K++ L Q + + +WL TE E+L +P S D + IE
Sbjct: 4246 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE---ELLDAQRPISGDPKVIE 4302
Query: 248 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 306
+ + + + ++A V +VN + E L++ + +++ L+SRL ++ WE+
Sbjct: 4303 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4362
Query: 307 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKAD 366
+ L+ +L Q QG FH ++ LL L +++ + T
Sbjct: 4363 EEREQQLQSTLQQAQG--------------FHSEIEDFLLELTRMESQLSASKPTG---- 4404
Query: 367 PRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGH---------------GEDCI 411
L E RE + EL Q+ +E N LL KG +
Sbjct: 4405 --GLPETAREQLDTHMELYS---QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA 4459
Query: 412 EAEEKVHVIEKKLKQLREQVSQDLMALQGTQN 443
E+K HV+ K+++ + ++ + L QN
Sbjct: 4460 LLEQKWHVVSSKMEERKSKLEEALNLATEFQN 4491
Score = 48.1 bits (113), Expect = 2e-05
Identities = 56/248 (22%), Positives = 102/248 (41%), Gaps = 22/248 (8%)
Query: 208 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ--EILKAFDTYKA 265
Q QQ A W+ +T+ +L L + D +L+V++ +I++ D+
Sbjct: 3713 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 3772
Query: 266 LVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKT 325
L + S+ F + T LQ + L +EA SL+ +
Sbjct: 3773 LF---SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI-------------SLLNSERYAR 3816
Query: 326 RPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELV 385
R+ VL F + + L W+ + R A + P D L + + E+ QL + +
Sbjct: 3817 LERAQVLV-NQFWETYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIA 3873
Query: 386 ERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA 445
E +P +D L +I L + + E+ EEK E Q++E+V Q +AL + +
Sbjct: 3874 EHKPHIDKLLKIGPQLK-ELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQS 3932
Query: 446 SPLPSFDE 453
+ + F +
Sbjct: 3933 TQITEFHD 3940
Score = 45.8 bits (107), Expect = 1e-04
Identities = 74/351 (21%), Positives = 141/351 (40%), Gaps = 36/351 (10%)
Query: 181 ITEQQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLK-M 236
IT Q RW + ++ + +++ L +Q + I+ +L TE +L + +
Sbjct: 3356 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3415
Query: 237 AKPPSDIQEIELRVKRLQEILK--AFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 294
+ IQ+ +R K L+E ++ A D ++A+ + ++SS T E L ++
Sbjct: 3416 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL----TSPAEQGVLSEKIDS 3471
Query: 295 LSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNR 354
L + Q L Q+L + LF +D +L WLA +++
Sbjct: 3472 LQARYSEIQDRCCRKAALLDQALSNAR----------LFGED----EVEVLNWLAEVEDK 3517
Query: 355 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 414
V D K D L + + L +E+V R+ VD + +LL + GE+ + +
Sbjct: 3518 LSSVFVKDFKQD--VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQ 3575
Query: 415 EKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFR 474
EK+ I+ + + S+ L L+ + A+ S E +G
Sbjct: 3576 EKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVE----------E 3625
Query: 475 AVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLP 525
+ T+ G+ T ++P + Q+ V+ L L + + L L+P
Sbjct: 3626 ELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 3676
Score = 42.7 bits (99), Expect = 9e-04
Identities = 44/211 (20%), Positives = 92/211 (43%), Gaps = 21/211 (9%)
Query: 199 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILK 258
EL ++ LQ+ D +WL+++E ELE M K S + + +KR +
Sbjct: 1806 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELE--NMHKGGSSPETLPSLLKRQGSFSE 1863
Query: 259 AFDTYKALVVSVNVSSKEFLQTESP-----ESTELQSRLRQLSLLWEAAQGAVDSWRGGL 313
++K + V +S ++ L E+ E +E+ + ++ L +A +
Sbjct: 1864 DVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK--LKDATE---------- 1911
Query: 314 RQSLMQCQGSKTRPRSDVLF--FKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALL 371
R + + + ++ ++L + F + +L W+ + + +K +DP L
Sbjct: 1912 RYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQ 1971
Query: 372 ECRRELMQLEKELVERQPQVDMLQEISNSLL 402
E QL++EL E Q V+ LQ+++ ++
Sbjct: 1972 EQLATTKQLQEELAEHQVPVEKLQKVARDIM 2002
Score = 34.7 bits (78), Expect = 0.24
Identities = 65/322 (20%), Positives = 126/322 (39%), Gaps = 35/322 (10%)
Query: 194 MIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL 253
M++ + + L +K+ L+ LN +T K + +LE+ +++ ++K L
Sbjct: 3124 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL-----GRVEDFYRKLKGL 3178
Query: 254 QEILKAFDTYKAL-------VVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA--QG 304
+ A + +AL V +N +F + + LQ +L+Q++ L +
Sbjct: 3179 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSA 3238
Query: 305 AVDSWRGGLRQSLMQCQG------SKTRPR-----SDVLFFKDFHQLSQNLLLWLASAKN 353
D GL + + K R +L F + LL WLA +
Sbjct: 3239 GKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEE 3298
Query: 354 RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEA 413
A+ P A+ + + +E L++ L +R+ VDMLQ + D +
Sbjct: 3299 LI--ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3356
Query: 414 EEKVHVIEKKLKQL------REQVSQDLMAL-QGTQNPASPLPSFDEVDSGDQPPATSVP 466
++ +E + +L R++ +D++ L + A P+ F V + V
Sbjct: 3357 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3416
Query: 467 APRAK-QFRAVRTTEGEEETES 487
AK Q + +R EE+ E+
Sbjct: 3417 TQTAKIQQQIIRHKALEEDIEN 3438
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 50.1 bits (118), Expect = 5e-06
Identities = 60/255 (23%), Positives = 102/255 (40%), Gaps = 22/255 (8%)
Query: 164 PRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQ-ELHNK-LKIKQNLQQLNSDISAIT 221
PR+ + +Q G A + + + W+ + + EL K L+ QQ D +
Sbjct: 1542 PRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAE 1601
Query: 222 TWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTE 281
W+ E EL M+ K ++ + VK+ Q + +A Y + + SS++ + E
Sbjct: 1602 AWMG--EQELHMMGQEKAKDELSA-QAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHE 1658
Query: 282 SPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLS 341
PEST + R Q+ L+ + R L++ L CQ + D Q
Sbjct: 1659 HPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE--------LDDLEQWI 1710
Query: 342 QNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSL 401
Q + AS + + HVT + R E R+ + +E +VD ++N L
Sbjct: 1711 QEREVVAASHELGQDYEHVTMLRDKFR---EFSRDTSTIGQE------RVDSANALANGL 1761
Query: 402 LIKGHGEDCIEAEEK 416
+ GH AE K
Sbjct: 1762 IAGGHAARATVAEWK 1776
Score = 40.0 bits (92), Expect = 0.006
Identities = 46/243 (18%), Positives = 98/243 (40%), Gaps = 31/243 (12%)
Query: 192 WEMIQAQ--ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR 249
+E +QA+ E L+ L + S+ A W+++ E L L + P ++++E+
Sbjct: 834 YEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLAL---PERLEDLEVV 890
Query: 250 VKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSW 309
+R + + +T A + +VN +++ L+ P + + QL+ W+ + D
Sbjct: 891 QQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGK 950
Query: 310 RGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKA---- 365
+ L + L +++H W+ R+K V +
Sbjct: 951 KAAL---------------TSALSIQNYHLECTETQAWM------REKTKVIESTQGLGN 989
Query: 366 DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLK 425
D +L +R+L E++L +V L +N+ L GH + ++ ++ +
Sbjct: 990 DLAGVLALQRKLAGTERDLEAIAARVGELTREANA-LAAGHPAQAVAINARLREVQTGWE 1048
Query: 426 QLR 428
LR
Sbjct: 1049 DLR 1051
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 48.5 bits (114), Expect = 2e-05
Identities = 46/242 (19%), Positives = 106/242 (43%), Gaps = 23/242 (9%)
Query: 190 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 246
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4736 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4793
Query: 247 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 306
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4794 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4853
Query: 307 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNR-RQKAHVTDPKA 365
S + L +L Q + +FH + LL WLA A+ R + D +
Sbjct: 4854 ISKQTRLEAALRQAE--------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDED 4899
Query: 366 DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLK 425
R L++ +E M K+L E++ +++ + +++L H + + + +I + +
Sbjct: 4900 ALRTLIDQHKEFM---KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4956
Query: 426 QL 427
++
Sbjct: 4957 EV 4958
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/209 (21%), Positives = 89/209 (42%), Gaps = 9/209 (4%)
Query: 199 ELHNKLKIKQNLQQ----LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 254
E K+K+ +LQ+ ++D + WL+++E ELE L+ DI + ++KR +
Sbjct: 1853 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAG--ADDINGLMTKLKRQK 1910
Query: 255 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 314
+ ++K + + +S L+ S ++ S Q +D R
Sbjct: 1911 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKV-DTSATHREVQRKLDHATDRFR 1969
Query: 315 QSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKA-DPRALLEC 373
+C + V ++ + S LL L + + K H+++P A DP+ L
Sbjct: 1970 SLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK-HLSEPIAVDPKNLQRQ 2028
Query: 374 RRELMQLEKELVERQPQVDMLQEISNSLL 402
E L+ ++ +Q V+ L++ + LL
Sbjct: 2029 LEETKALQGQISSQQVAVEKLKKTAEVLL 2057
Score = 39.7 bits (91), Expect = 0.007
Identities = 60/291 (20%), Positives = 113/291 (38%), Gaps = 40/291 (13%)
Query: 161 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 207
K G VLNG N ++ + GL I + + +E + + EL+ KL
Sbjct: 2399 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2456
Query: 208 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 267
LQ+ + SA+ WL+K + P+D + ++ +V++ + V
Sbjct: 2457 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2515
Query: 268 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLW-EAAQGAVDSWRGGLRQSLMQCQGSK 324
+ E L+ ++PE+ + L ++ W E Q +D +Q L + +
Sbjct: 2516 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR-----QQKLEESSNNL 2570
Query: 325 TRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKE 383
T+ F + L WL + V P DP L R+++ L +E
Sbjct: 2571 TQ----------FQTVEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQE 2617
Query: 384 LVERQPQVDMLQEISNSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 432
R+PQ + L +L + + + +E++ + +K L Q+S
Sbjct: 2618 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2668
Score = 34.7 bits (78), Expect = 0.24
Identities = 55/270 (20%), Positives = 103/270 (38%), Gaps = 32/270 (11%)
Query: 174 EDGGLAGITEQQSGAF-DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEA 229
ED L GI ++Q A +W+ + Q I Q + Q S + +++ L +
Sbjct: 2641 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2700
Query: 230 ELE--MLKMAKPPSDIQEIELRVKRLQEIL---KAFDTYKALVVSVNVSSKE-FLQTESP 283
+L + P + Q++E K QEI K +AL ++ KE +L+ E
Sbjct: 2701 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAEL- 2759
Query: 284 ESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQN 343
S +L+ L+ + + A+ V + S F Q+S++
Sbjct: 2760 -SRQLEGILKSFKDVEQKAENHVQHLQSACASS------------------HQFQQMSRD 2800
Query: 344 LLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLI 403
WL + K + K+H K D L ++ K L + + +LL+
Sbjct: 2801 FQAWLDTKKEEQNKSHPISAKLD--VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2858
Query: 404 KGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 433
K G + + +++ I+ +QV +
Sbjct: 2859 KTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2888
Score = 34.3 bits (77), Expect = 0.31
Identities = 52/259 (20%), Positives = 96/259 (37%), Gaps = 29/259 (11%)
Query: 198 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 257
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2782 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2836
Query: 258 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 315
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2837 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2895
Query: 316 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 375
SL + K + + L W+ +N ++ DP
Sbjct: 2896 SLEKALKYKEQV--------------ETLWPWIDKCQNNLEEIKFC---LDPAEGENSIA 2938
Query: 376 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 435
+L L+KE+ + V++L +NSLL + + +E +I+ K+ + EQ+
Sbjct: 2939 KLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKK 2997
Query: 436 MALQGTQNPASPLPSFDEV 454
L +N F EV
Sbjct: 2998 FCL---ENMTQKFKEFQEV 3013
Score = 29.6 bits (65), Expect = 7.6
Identities = 35/205 (17%), Positives = 90/205 (43%), Gaps = 32/205 (15%)
Query: 206 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 262
+ QNL +++N + + W+ + + +L+ + SD+ +E ++ + + +A +
Sbjct: 623 LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 679
Query: 263 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQG 322
+++ + +S +Q +P +L +L + L+
Sbjct: 680 FESSLKEAKISE---IQMTAPLKLTYAEKLHRLESQYA---------------KLLNTSR 721
Query: 323 SKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLE 381
++ R D L +F + N L+WL N +++ V ++ + +++ +L
Sbjct: 722 NQER-HLDTLH--NFVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELM 774
Query: 382 KELVERQPQVDMLQEISNSLLIKGH 406
+EL +++ + +QEI+ LL++ H
Sbjct: 775 RELDQKEENIKSVQEIAEQLLLENH 799
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 48.5 bits (114), Expect = 2e-05
Identities = 46/242 (19%), Positives = 106/242 (43%), Gaps = 23/242 (9%)
Query: 190 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 246
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4747 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4804
Query: 247 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 306
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4805 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4864
Query: 307 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNR-RQKAHVTDPKA 365
S + L +L Q + +FH + LL WLA A+ R + D +
Sbjct: 4865 ISKQTRLEAALRQAE--------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDED 4910
Query: 366 DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLK 425
R L++ +E M K+L E++ +++ + +++L H + + + +I + +
Sbjct: 4911 ALRTLIDQHKEFM---KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967
Query: 426 QL 427
++
Sbjct: 4968 EV 4969
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/209 (21%), Positives = 89/209 (42%), Gaps = 9/209 (4%)
Query: 199 ELHNKLKIKQNLQQ----LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 254
E K+K+ +LQ+ ++D + WL+++E ELE L+ DI + ++KR +
Sbjct: 1864 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAG--ADDINGLMTKLKRQK 1921
Query: 255 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 314
+ ++K + + +S L+ S ++ S Q +D R
Sbjct: 1922 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKV-DTSATHREVQRKLDHATDRFR 1980
Query: 315 QSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKA-DPRALLEC 373
+C + V ++ + S LL L + + K H+++P A DP+ L
Sbjct: 1981 SLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK-HLSEPIAVDPKNLQRQ 2039
Query: 374 RRELMQLEKELVERQPQVDMLQEISNSLL 402
E L+ ++ +Q V+ L++ + LL
Sbjct: 2040 LEETKALQGQISSQQVAVEKLKKTAEVLL 2068
Score = 39.7 bits (91), Expect = 0.007
Identities = 60/291 (20%), Positives = 113/291 (38%), Gaps = 40/291 (13%)
Query: 161 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 207
K G VLNG N ++ + GL I + + +E + + EL+ KL
Sbjct: 2410 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2467
Query: 208 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 267
LQ+ + SA+ WL+K + P+D + ++ +V++ + V
Sbjct: 2468 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2526
Query: 268 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLW-EAAQGAVDSWRGGLRQSLMQCQGSK 324
+ E L+ ++PE+ + L ++ W E Q +D +Q L + +
Sbjct: 2527 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR-----QQKLEESSNNL 2581
Query: 325 TRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKE 383
T+ F + L WL + V P DP L R+++ L +E
Sbjct: 2582 TQ----------FQTVEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQE 2628
Query: 384 LVERQPQVDMLQEISNSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 432
R+PQ + L +L + + + +E++ + +K L Q+S
Sbjct: 2629 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2679
Score = 34.7 bits (78), Expect = 0.24
Identities = 55/270 (20%), Positives = 103/270 (38%), Gaps = 32/270 (11%)
Query: 174 EDGGLAGITEQQSGAF-DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEA 229
ED L GI ++Q A +W+ + Q I Q + Q S + +++ L +
Sbjct: 2652 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2711
Query: 230 ELE--MLKMAKPPSDIQEIELRVKRLQEIL---KAFDTYKALVVSVNVSSKE-FLQTESP 283
+L + P + Q++E K QEI K +AL ++ KE +L+ E
Sbjct: 2712 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAEL- 2770
Query: 284 ESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQN 343
S +L+ L+ + + A+ V + S F Q+S++
Sbjct: 2771 -SRQLEGILKSFKDVEQKAENHVQHLQSACASS------------------HQFQQMSRD 2811
Query: 344 LLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLI 403
WL + K + K+H K D L ++ K L + + +LL+
Sbjct: 2812 FQAWLDTKKEEQNKSHPISAKLD--VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2869
Query: 404 KGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 433
K G + + +++ I+ +QV +
Sbjct: 2870 KTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2899
Score = 34.3 bits (77), Expect = 0.31
Identities = 52/259 (20%), Positives = 96/259 (37%), Gaps = 29/259 (11%)
Query: 198 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 257
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2793 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2847
Query: 258 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 315
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2848 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2906
Query: 316 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 375
SL + K + + L W+ +N ++ DP
Sbjct: 2907 SLEKALKYKEQV--------------ETLWPWIDKCQNNLEEIKFC---LDPAEGENSIA 2949
Query: 376 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 435
+L L+KE+ + V++L +NSLL + + +E +I+ K+ + EQ+
Sbjct: 2950 KLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKK 3008
Query: 436 MALQGTQNPASPLPSFDEV 454
L +N F EV
Sbjct: 3009 FCL---ENMTQKFKEFQEV 3024
Score = 29.6 bits (65), Expect = 7.6
Identities = 35/205 (17%), Positives = 90/205 (43%), Gaps = 32/205 (15%)
Query: 206 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 262
+ QNL +++N + + W+ + + +L+ + SD+ +E ++ + + +A +
Sbjct: 634 LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 690
Query: 263 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQG 322
+++ + +S +Q +P +L +L + L+
Sbjct: 691 FESSLKEAKISE---IQMTAPLKLTYAEKLHRLESQYA---------------KLLNTSR 732
Query: 323 SKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLE 381
++ R D L +F + N L+WL N +++ V ++ + +++ +L
Sbjct: 733 NQER-HLDTLH--NFVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELM 785
Query: 382 KELVERQPQVDMLQEISNSLLIKGH 406
+EL +++ + +QEI+ LL++ H
Sbjct: 786 RELDQKEENIKSVQEIAEQLLLENH 810
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 48.5 bits (114), Expect = 2e-05
Identities = 46/242 (19%), Positives = 106/242 (43%), Gaps = 23/242 (9%)
Query: 190 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 246
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4885 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4942
Query: 247 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 306
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4943 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 5002
Query: 307 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNR-RQKAHVTDPKA 365
S + L +L Q + +FH + LL WLA A+ R + D +
Sbjct: 5003 ISKQTRLEAALRQAE--------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDED 5048
Query: 366 DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLK 425
R L++ +E M K+L E++ +++ + +++L H + + + +I + +
Sbjct: 5049 ALRTLIDQHKEFM---KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 5105
Query: 426 QL 427
++
Sbjct: 5106 EV 5107
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/209 (21%), Positives = 89/209 (42%), Gaps = 9/209 (4%)
Query: 199 ELHNKLKIKQNLQQ----LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 254
E K+K+ +LQ+ ++D + WL+++E ELE L+ DI + ++KR +
Sbjct: 2002 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAG--ADDINGLMTKLKRQK 2059
Query: 255 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 314
+ ++K + + +S L+ S ++ S Q +D R
Sbjct: 2060 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKV-DTSATHREVQRKLDHATDRFR 2118
Query: 315 QSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKA-DPRALLEC 373
+C + V ++ + S LL L + + K H+++P A DP+ L
Sbjct: 2119 SLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK-HLSEPIAVDPKNLQRQ 2177
Query: 374 RRELMQLEKELVERQPQVDMLQEISNSLL 402
E L+ ++ +Q V+ L++ + LL
Sbjct: 2178 LEETKALQGQISSQQVAVEKLKKTAEVLL 2206
Score = 39.7 bits (91), Expect = 0.007
Identities = 60/291 (20%), Positives = 113/291 (38%), Gaps = 40/291 (13%)
Query: 161 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 207
K G VLNG N ++ + GL I + + +E + + EL+ KL
Sbjct: 2548 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2605
Query: 208 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 267
LQ+ + SA+ WL+K + P+D + ++ +V++ + V
Sbjct: 2606 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2664
Query: 268 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLW-EAAQGAVDSWRGGLRQSLMQCQGSK 324
+ E L+ ++PE+ + L ++ W E Q +D +Q L + +
Sbjct: 2665 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR-----QQKLEESSNNL 2719
Query: 325 TRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKE 383
T+ F + L WL + V P DP L R+++ L +E
Sbjct: 2720 TQ----------FQTVEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQE 2766
Query: 384 LVERQPQVDMLQEISNSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 432
R+PQ + L +L + + + +E++ + +K L Q+S
Sbjct: 2767 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2817
Score = 34.7 bits (78), Expect = 0.24
Identities = 55/270 (20%), Positives = 103/270 (38%), Gaps = 32/270 (11%)
Query: 174 EDGGLAGITEQQSGAF-DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEA 229
ED L GI ++Q A +W+ + Q I Q + Q S + +++ L +
Sbjct: 2790 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2849
Query: 230 ELE--MLKMAKPPSDIQEIELRVKRLQEIL---KAFDTYKALVVSVNVSSKE-FLQTESP 283
+L + P + Q++E K QEI K +AL ++ KE +L+ E
Sbjct: 2850 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAEL- 2908
Query: 284 ESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQN 343
S +L+ L+ + + A+ V + S F Q+S++
Sbjct: 2909 -SRQLEGILKSFKDVEQKAENHVQHLQSACASS------------------HQFQQMSRD 2949
Query: 344 LLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLI 403
WL + K + K+H K D L ++ K L + + +LL+
Sbjct: 2950 FQAWLDTKKEEQNKSHPISAKLD--VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 3007
Query: 404 KGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 433
K G + + +++ I+ +QV +
Sbjct: 3008 KTQGSEKAALQLQLNTIKTNWDTFNKQVKE 3037
Score = 34.3 bits (77), Expect = 0.31
Identities = 52/259 (20%), Positives = 96/259 (37%), Gaps = 29/259 (11%)
Query: 198 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 257
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2931 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2985
Query: 258 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 315
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2986 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 3044
Query: 316 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 375
SL + K + + L W+ +N ++ DP
Sbjct: 3045 SLEKALKYKEQV--------------ETLWPWIDKCQNNLEEIKFC---LDPAEGENSIA 3087
Query: 376 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 435
+L L+KE+ + V++L +NSLL + + +E +I+ K+ + EQ+
Sbjct: 3088 KLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKK 3146
Query: 436 MALQGTQNPASPLPSFDEV 454
L +N F EV
Sbjct: 3147 FCL---ENMTQKFKEFQEV 3162
Score = 29.6 bits (65), Expect = 7.6
Identities = 35/205 (17%), Positives = 90/205 (43%), Gaps = 32/205 (15%)
Query: 206 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 262
+ QNL +++N + + W+ + + +L+ + SD+ +E ++ + + +A +
Sbjct: 772 LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 828
Query: 263 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQG 322
+++ + +S +Q +P +L +L + L+
Sbjct: 829 FESSLKEAKISE---IQMTAPLKLTYAEKLHRLESQYA---------------KLLNTSR 870
Query: 323 SKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLE 381
++ R D L +F + N L+WL N +++ V ++ + +++ +L
Sbjct: 871 NQER-HLDTLH--NFVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELM 923
Query: 382 KELVERQPQVDMLQEISNSLLIKGH 406
+EL +++ + +QEI+ LL++ H
Sbjct: 924 RELDQKEENIKSVQEIAEQLLLENH 948
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 48.5 bits (114), Expect = 2e-05
Identities = 46/242 (19%), Positives = 106/242 (43%), Gaps = 23/242 (9%)
Query: 190 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 246
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4707 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4764
Query: 247 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 306
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4765 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4824
Query: 307 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNR-RQKAHVTDPKA 365
S + L +L Q + +FH + LL WLA A+ R + D +
Sbjct: 4825 ISKQTRLEAALRQAE--------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDED 4870
Query: 366 DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLK 425
R L++ +E M K+L E++ +++ + +++L H + + + +I + +
Sbjct: 4871 ALRTLIDQHKEFM---KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927
Query: 426 QL 427
++
Sbjct: 4928 EV 4929
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/209 (21%), Positives = 89/209 (42%), Gaps = 9/209 (4%)
Query: 199 ELHNKLKIKQNLQQ----LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 254
E K+K+ +LQ+ ++D + WL+++E ELE L+ DI + ++KR +
Sbjct: 1824 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAG--ADDINGLMTKLKRQK 1881
Query: 255 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 314
+ ++K + + +S L+ S ++ S Q +D R
Sbjct: 1882 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKV-DTSATHREVQRKLDHATDRFR 1940
Query: 315 QSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKA-DPRALLEC 373
+C + V ++ + S LL L + + K H+++P A DP+ L
Sbjct: 1941 SLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK-HLSEPIAVDPKNLQRQ 1999
Query: 374 RRELMQLEKELVERQPQVDMLQEISNSLL 402
E L+ ++ +Q V+ L++ + LL
Sbjct: 2000 LEETKALQGQISSQQVAVEKLKKTAEVLL 2028
Score = 39.7 bits (91), Expect = 0.007
Identities = 60/291 (20%), Positives = 113/291 (38%), Gaps = 40/291 (13%)
Query: 161 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 207
K G VLNG N ++ + GL I + + +E + + EL+ KL
Sbjct: 2370 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2427
Query: 208 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 267
LQ+ + SA+ WL+K + P+D + ++ +V++ + V
Sbjct: 2428 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2486
Query: 268 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLW-EAAQGAVDSWRGGLRQSLMQCQGSK 324
+ E L+ ++PE+ + L ++ W E Q +D +Q L + +
Sbjct: 2487 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR-----QQKLEESSNNL 2541
Query: 325 TRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKE 383
T+ F + L WL + V P DP L R+++ L +E
Sbjct: 2542 TQ----------FQTVEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQE 2588
Query: 384 LVERQPQVDMLQEISNSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 432
R+PQ + L +L + + + +E++ + +K L Q+S
Sbjct: 2589 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2639
Score = 34.7 bits (78), Expect = 0.24
Identities = 55/270 (20%), Positives = 103/270 (38%), Gaps = 32/270 (11%)
Query: 174 EDGGLAGITEQQSGAF-DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEA 229
ED L GI ++Q A +W+ + Q I Q + Q S + +++ L +
Sbjct: 2612 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2671
Query: 230 ELE--MLKMAKPPSDIQEIELRVKRLQEIL---KAFDTYKALVVSVNVSSKE-FLQTESP 283
+L + P + Q++E K QEI K +AL ++ KE +L+ E
Sbjct: 2672 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAEL- 2730
Query: 284 ESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQN 343
S +L+ L+ + + A+ V + S F Q+S++
Sbjct: 2731 -SRQLEGILKSFKDVEQKAENHVQHLQSACASS------------------HQFQQMSRD 2771
Query: 344 LLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLI 403
WL + K + K+H K D L ++ K L + + +LL+
Sbjct: 2772 FQAWLDTKKEEQNKSHPISAKLD--VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2829
Query: 404 KGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 433
K G + + +++ I+ +QV +
Sbjct: 2830 KTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2859
Score = 34.3 bits (77), Expect = 0.31
Identities = 52/259 (20%), Positives = 96/259 (37%), Gaps = 29/259 (11%)
Query: 198 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 257
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2753 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2807
Query: 258 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 315
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2808 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2866
Query: 316 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 375
SL + K + + L W+ +N ++ DP
Sbjct: 2867 SLEKALKYKEQV--------------ETLWPWIDKCQNNLEEIKFC---LDPAEGENSIA 2909
Query: 376 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 435
+L L+KE+ + V++L +NSLL + + +E +I+ K+ + EQ+
Sbjct: 2910 KLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKK 2968
Query: 436 MALQGTQNPASPLPSFDEV 454
L +N F EV
Sbjct: 2969 FCL---ENMTQKFKEFQEV 2984
Score = 29.6 bits (65), Expect = 7.6
Identities = 35/205 (17%), Positives = 90/205 (43%), Gaps = 32/205 (15%)
Query: 206 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 262
+ QNL +++N + + W+ + + +L+ + SD+ +E ++ + + +A +
Sbjct: 594 LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 650
Query: 263 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQG 322
+++ + +S +Q +P +L +L + L+
Sbjct: 651 FESSLKEAKISE---IQMTAPLKLTYAEKLHRLESQYA---------------KLLNTSR 692
Query: 323 SKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLE 381
++ R D L +F + N L+WL N +++ V ++ + +++ +L
Sbjct: 693 NQER-HLDTLH--NFVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELM 745
Query: 382 KELVERQPQVDMLQEISNSLLIKGH 406
+EL +++ + +QEI+ LL++ H
Sbjct: 746 RELDQKEENIKSVQEIAEQLLLENH 770
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 48.5 bits (114), Expect = 2e-05
Identities = 46/242 (19%), Positives = 106/242 (43%), Gaps = 23/242 (9%)
Query: 190 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 246
D+W+ I + + + K+++ L Q + A+ WL + E +L + DI +
Sbjct: 4381 DKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLV 4438
Query: 247 ELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAV 306
+ + K + V ++ S++E ++ +S+ ++ ++++LS WE
Sbjct: 4439 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALS 4498
Query: 307 DSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNR-RQKAHVTDPKA 365
S + L +L Q + +FH + LL WLA A+ R + D +
Sbjct: 4499 ISKQTRLEAALRQAE--------------EFHSVVHALLEWLAEAEQTLRFHGVLPDDED 4544
Query: 366 DPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLK 425
R L++ +E M K+L E++ +++ + +++L H + + + +I + +
Sbjct: 4545 ALRTLIDQHKEFM---KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4601
Query: 426 QL 427
++
Sbjct: 4602 EV 4603
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/209 (21%), Positives = 89/209 (42%), Gaps = 9/209 (4%)
Query: 199 ELHNKLKIKQNLQQ----LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ 254
E K+K+ +LQ+ ++D + WL+++E ELE L+ DI + ++KR +
Sbjct: 1498 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAG--ADDINGLMTKLKRQK 1555
Query: 255 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 314
+ ++K + + +S L+ S ++ S Q +D R
Sbjct: 1556 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKV-DTSATHREVQRKLDHATDRFR 1614
Query: 315 QSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKA-DPRALLEC 373
+C + V ++ + S LL L + + K H+++P A DP+ L
Sbjct: 1615 SLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK-HLSEPIAVDPKNLQRQ 1673
Query: 374 RRELMQLEKELVERQPQVDMLQEISNSLL 402
E L+ ++ +Q V+ L++ + LL
Sbjct: 1674 LEETKALQGQISSQQVAVEKLKKTAEVLL 1702
Score = 39.7 bits (91), Expect = 0.007
Identities = 60/291 (20%), Positives = 113/291 (38%), Gaps = 40/291 (13%)
Query: 161 KEGPRVLNG-----NPQQ--EDGGLAGITEQQSGAFDRWEMI------QAQELHNKLKIK 207
K G VLNG N ++ + GL I + + +E + + EL+ KL
Sbjct: 2044 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS-- 2101
Query: 208 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 267
LQ+ + SA+ WL+K + P+D + ++ +V++ + V
Sbjct: 2102 -KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2160
Query: 268 VSVNVSSKEFLQ--TESPESTELQSRLRQLSLLW-EAAQGAVDSWRGGLRQSLMQCQGSK 324
+ E L+ ++PE+ + L ++ W E Q +D +Q L + +
Sbjct: 2161 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR-----QQKLEESSNNL 2215
Query: 325 TRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDP-KADPRALLECRRELMQLEKE 383
T+ F + L WL + V P DP L R+++ L +E
Sbjct: 2216 TQ----------FQTVEAQLKQWLV---EKELMVSVLGPLSIDPNMLNTQRQQVQILLQE 2262
Query: 384 LVERQPQVDMLQEISNSLLIKGHGEDCIE--AEEKVHVIEKKLKQLREQVS 432
R+PQ + L +L + + + +E++ + +K L Q+S
Sbjct: 2263 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2313
Score = 34.7 bits (78), Expect = 0.24
Identities = 55/270 (20%), Positives = 103/270 (38%), Gaps = 32/270 (11%)
Query: 174 EDGGLAGITEQQSGAF-DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEA 229
ED L GI ++Q A +W+ + Q I Q + Q S + +++ L +
Sbjct: 2286 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2345
Query: 230 ELE--MLKMAKPPSDIQEIELRVKRLQEIL---KAFDTYKALVVSVNVSSKE-FLQTESP 283
+L + P + Q++E K QEI K +AL ++ KE +L+ E
Sbjct: 2346 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAEL- 2404
Query: 284 ESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQN 343
S +L+ L+ + + A+ V + S F Q+S++
Sbjct: 2405 -SRQLEGILKSFKDVEQKAENHVQHLQSACASS------------------HQFQQMSRD 2445
Query: 344 LLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLI 403
WL + K + K+H K D L ++ K L + + +LL+
Sbjct: 2446 FQAWLDTKKEEQNKSHPISAKLD--VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2503
Query: 404 KGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 433
K G + + +++ I+ +QV +
Sbjct: 2504 KTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2533
Score = 34.3 bits (77), Expect = 0.31
Identities = 52/259 (20%), Positives = 96/259 (37%), Gaps = 29/259 (11%)
Query: 198 QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL 257
Q L + QQ++ D A WL + E D+ +E +K ++
Sbjct: 2427 QHLQSACASSHQFQQMSRDFQA---WLDTKKEEQNKSHPISAKLDV--LESLIKDHKDFS 2481
Query: 258 KAFDTYKALVVSVNVSSKE--FLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 315
K T ++ + ++ E L+T+ E LQ +L + W+ V L++
Sbjct: 2482 KTL-TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2540
Query: 316 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 375
SL + K + + L W+ +N ++ DP
Sbjct: 2541 SLEKALKYKEQV--------------ETLWPWIDKCQNNLEEIKFC---LDPAEGENSIA 2583
Query: 376 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 435
+L L+KE+ + V++L +NSLL + + +E +I+ K+ + EQ+
Sbjct: 2584 KLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKK 2642
Query: 436 MALQGTQNPASPLPSFDEV 454
L +N F EV
Sbjct: 2643 FCL---ENMTQKFKEFQEV 2658
Score = 29.6 bits (65), Expect = 7.6
Identities = 35/205 (17%), Positives = 90/205 (43%), Gaps = 32/205 (15%)
Query: 206 IKQNL--QQLNSD-ISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDT 262
+ QNL +++N + + W+ + + +L+ + SD+ +E ++ + + +A +
Sbjct: 268 LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG---SDLPSVESHLENHKNVHRAIEE 324
Query: 263 YKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQG 322
+++ + +S +Q +P +L +L + L+
Sbjct: 325 FESSLKEAKISE---IQMTAPLKLTYAEKLHRLESQYA---------------KLLNTSR 366
Query: 323 SKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL-MQLE 381
++ R D L +F + N L+WL N +++ V ++ + +++ +L
Sbjct: 367 NQER-HLDTLH--NFVSRATNELIWL----NEKEEEEVAYDWSERNTNIARKKDYHAELM 419
Query: 382 KELVERQPQVDMLQEISNSLLIKGH 406
+EL +++ + +QEI+ LL++ H
Sbjct: 420 RELDQKEENIKSVQEIAEQLLLENH 444
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 47.8 bits (112), Expect = 3e-05
Identities = 51/217 (23%), Positives = 90/217 (41%), Gaps = 23/217 (10%)
Query: 192 WEMIQ--AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR 249
WE I+ A E H +L LQ+ +D +T+W+ + +A + ++A SD+ E
Sbjct: 343 WEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELA---SDVAGAEAL 399
Query: 250 VKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSW 309
+ R QE D ++ S + S + L S E++ +L LS E ++ W
Sbjct: 400 LDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLS---EERAALLELW 456
Query: 310 RGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRA 369
RQ QC + LF++D Q+ W++ + + D A
Sbjct: 457 E-LRRQQYEQCMDLQ-------LFYRDTEQVDN----WMSKQEAFLLNEDLGDSLDSVEA 504
Query: 370 LLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGH 406
LL+ + EK L ++ ++ L E + L+ H
Sbjct: 505 LLKKHED---FEKSLSAQEEKITALDEFATKLIQNNH 538
Score = 43.5 bits (101), Expect = 5e-04
Identities = 55/300 (18%), Positives = 127/300 (42%), Gaps = 32/300 (10%)
Query: 161 KEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWE-MIQAQELHN-KLKIKQNLQQLNSDIS 218
K G ++++ N +D A + E W+ +++A EL KL+ QQ N ++
Sbjct: 633 KAGQKLIDVNHYAKDEVAARMNE----VISLWKKLLEATELKGIKLREANQQQQFNRNVE 688
Query: 219 AITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFL 278
I WL + E L K +++Q ++ + L+ + A ++ + + + +++F
Sbjct: 689 DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAA---HQDRIDGITIQARQFQ 745
Query: 279 QTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFH 338
++ ++ + L +EA + + + + L SL Q F+D
Sbjct: 746 DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ-----------LFRDV- 793
Query: 339 QLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEIS 398
++ W+ + + A T+ D + ++ L+ E+ +P++ + +
Sbjct: 794 ---EDEETWI---REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
Query: 399 NSLLIKGH--GEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDS 456
N+++ +GH ED + K+H + +K + L+ + SQ L+ + +E +S
Sbjct: 848 NAMVEEGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAES 904
Score = 38.5 bits (88), Expect = 0.016
Identities = 25/125 (20%), Positives = 59/125 (47%), Gaps = 5/125 (4%)
Query: 191 RWEMI--QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIEL 248
+WE++ + +E KL Q L Q + + W+ EA + ++ + D++ +E+
Sbjct: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQ---DLEHVEV 186
Query: 249 RVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDS 308
K+ +E ++ V VN + + +Q + PE ++++ +++ W+ +G
Sbjct: 187 LQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQ 246
Query: 309 WRGGL 313
+G L
Sbjct: 247 RQGKL 251
Score = 37.4 bits (85), Expect = 0.036
Identities = 53/257 (20%), Positives = 96/257 (37%), Gaps = 32/257 (12%)
Query: 192 WEMIQAQELHNKLKI--KQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR 249
W+ ++ L + K+ +Q+ N D+ +W+K+ E + + + +Q + +
Sbjct: 237 WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296
Query: 250 VKRLQEILKAF-DTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDS 308
+ L+ L A D KAL + Q+ +T++Q + +L WE +
Sbjct: 297 HEGLERDLAALEDKVKALCAEAD----RLQQSHPLSATQIQVKREELITNWEQIRTLAAE 352
Query: 309 WRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 368
L S + F DF L+ W+ K + A
Sbjct: 353 RHARLNDSYRLQR-----------FLADFRDLTS----WVTEMKALINADELASDVAGAE 397
Query: 369 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEK------ 422
ALL+ +E + E+ + E +LL GH E EK+ V+ +
Sbjct: 398 ALLDRHQE---HKGEIDAHEDSFKSADESGQALLAAGHYAS-DEVREKLTVLSEERAALL 453
Query: 423 KLKQLREQVSQDLMALQ 439
+L +LR Q + M LQ
Sbjct: 454 ELWELRRQQYEQCMDLQ 470
Score = 36.2 bits (82), Expect = 0.081
Identities = 45/251 (17%), Positives = 93/251 (37%), Gaps = 24/251 (9%)
Query: 190 DRWEMIQ--AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIE 247
+RW +Q A+E L +Q+ + D W+++ L + +Q ++
Sbjct: 1213 ERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQ 1272
Query: 248 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVD 307
+ + + L A V S+ +++ +Q+ + +LQ + +L+ W + D
Sbjct: 1273 RKHEGFERDLAALGDK---VNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRAD 1329
Query: 308 SWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADP 367
+ L S F DF ++L+ W+ + +
Sbjct: 1330 QRKAKLGDS-----------HDLQRFLSDF----RDLMSWINGIRGLVSSDELAKDVTGA 1374
Query: 368 RALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 427
ALLE +E E+ R ++ LL GH E ++K+ +++++ L
Sbjct: 1375 EALLERHQE---HRTEIDARAGTFQAFEQFGQQLLAHGHYAS-PEIKQKLDILDQERADL 1430
Query: 428 REQVSQDLMAL 438
+ Q M L
Sbjct: 1431 EKAWVQRRMML 1441
Score = 35.8 bits (81), Expect = 0.11
Identities = 20/66 (30%), Positives = 36/66 (54%), Gaps = 3/66 (4%)
Query: 181 ITEQQSGAFDRWEMIQAQ--ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAK 238
I+ +++ DRW ++AQ E +KL Q LQQ + D+ I W+ + + + + K
Sbjct: 1522 ISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE-KLQTASDESYK 1580
Query: 239 PPSDIQ 244
P++IQ
Sbjct: 1581 DPTNIQ 1586
Score = 35.0 bits (79), Expect = 0.18
Identities = 44/239 (18%), Positives = 92/239 (38%), Gaps = 27/239 (11%)
Query: 169 GNPQQEDGGLAG----ITEQQSGAFDRWEMI--QAQELHNKLKIKQNLQQLNSDISAITT 222
GN E G AG + + + D+W+ + ++ E KLK Q N+ I
Sbjct: 1613 GNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDF 1672
Query: 223 WLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES 282
WL + EA L K D+ + +K+ Q + ++ + +N + + + +
Sbjct: 1673 WLSEVEALLASEDYGK---DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSA 1729
Query: 283 PESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQ 342
++++++ + ++ ++ + S R L +S Q FF+D
Sbjct: 1730 FDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQ-----------FFRDMDDEES 1778
Query: 343 NLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSL 401
W+ K ++ D D + R++ +LE EL +P + + + L
Sbjct: 1779 ----WI---KEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKL 1830
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 47.8 bits (112), Expect = 3e-05
Identities = 51/217 (23%), Positives = 90/217 (41%), Gaps = 23/217 (10%)
Query: 192 WEMIQ--AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR 249
WE I+ A E H +L LQ+ +D +T+W+ + +A + ++A SD+ E
Sbjct: 343 WEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELA---SDVAGAEAL 399
Query: 250 VKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSW 309
+ R QE D ++ S + S + L S E++ +L LS E ++ W
Sbjct: 400 LDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLS---EERAALLELW 456
Query: 310 RGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRA 369
RQ QC + LF++D Q+ W++ + + D A
Sbjct: 457 E-LRRQQYEQCMDLQ-------LFYRDTEQVDN----WMSKQEAFLLNEDLGDSLDSVEA 504
Query: 370 LLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGH 406
LL+ + EK L ++ ++ L E + L+ H
Sbjct: 505 LLKKHED---FEKSLSAQEEKITALDEFATKLIQNNH 538
Score = 43.5 bits (101), Expect = 5e-04
Identities = 55/300 (18%), Positives = 127/300 (42%), Gaps = 32/300 (10%)
Query: 161 KEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWE-MIQAQELHN-KLKIKQNLQQLNSDIS 218
K G ++++ N +D A + E W+ +++A EL KL+ QQ N ++
Sbjct: 633 KAGQKLIDVNHYAKDEVAARMNE----VISLWKKLLEATELKGIKLREANQQQQFNRNVE 688
Query: 219 AITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFL 278
I WL + E L K +++Q ++ + L+ + A ++ + + + +++F
Sbjct: 689 DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAA---HQDRIDGITIQARQFQ 745
Query: 279 QTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFH 338
++ ++ + L +EA + + + + L SL Q F+D
Sbjct: 746 DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ-----------LFRDV- 793
Query: 339 QLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEIS 398
++ W+ + + A T+ D + ++ L+ E+ +P++ + +
Sbjct: 794 ---EDEETWI---REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
Query: 399 NSLLIKGH--GEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDS 456
N+++ +GH ED + K+H + +K + L+ + SQ L+ + +E +S
Sbjct: 848 NAMVEEGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAES 904
Score = 38.5 bits (88), Expect = 0.016
Identities = 25/125 (20%), Positives = 59/125 (47%), Gaps = 5/125 (4%)
Query: 191 RWEMI--QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIEL 248
+WE++ + +E KL Q L Q + + W+ EA + ++ + D++ +E+
Sbjct: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQ---DLEHVEV 186
Query: 249 RVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDS 308
K+ +E ++ V VN + + +Q + PE ++++ +++ W+ +G
Sbjct: 187 LQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQ 246
Query: 309 WRGGL 313
+G L
Sbjct: 247 RQGKL 251
Score = 37.4 bits (85), Expect = 0.036
Identities = 53/257 (20%), Positives = 96/257 (37%), Gaps = 32/257 (12%)
Query: 192 WEMIQAQELHNKLKI--KQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELR 249
W+ ++ L + K+ +Q+ N D+ +W+K+ E + + + +Q + +
Sbjct: 237 WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296
Query: 250 VKRLQEILKAF-DTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDS 308
+ L+ L A D KAL + Q+ +T++Q + +L WE +
Sbjct: 297 HEGLERDLAALEDKVKALCAEAD----RLQQSHPLSATQIQVKREELITNWEQIRTLAAE 352
Query: 309 WRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 368
L S + F DF L+ W+ K + A
Sbjct: 353 RHARLNDSYRLQR-----------FLADFRDLTS----WVTEMKALINADELASDVAGAE 397
Query: 369 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEK------ 422
ALL+ +E + E+ + E +LL GH E EK+ V+ +
Sbjct: 398 ALLDRHQE---HKGEIDAHEDSFKSADESGQALLAAGHYAS-DEVREKLTVLSEERAALL 453
Query: 423 KLKQLREQVSQDLMALQ 439
+L +LR Q + M LQ
Sbjct: 454 ELWELRRQQYEQCMDLQ 470
Score = 36.2 bits (82), Expect = 0.081
Identities = 45/251 (17%), Positives = 93/251 (37%), Gaps = 24/251 (9%)
Query: 190 DRWEMIQ--AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIE 247
+RW +Q A+E L +Q+ + D W+++ L + +Q ++
Sbjct: 1213 ERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQ 1272
Query: 248 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVD 307
+ + + L A V S+ +++ +Q+ + +LQ + +L+ W + D
Sbjct: 1273 RKHEGFERDLAALGDK---VNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRAD 1329
Query: 308 SWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADP 367
+ L S F DF ++L+ W+ + +
Sbjct: 1330 QRKAKLGDS-----------HDLQRFLSDF----RDLMSWINGIRGLVSSDELAKDVTGA 1374
Query: 368 RALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL 427
ALLE +E E+ R ++ LL GH E ++K+ +++++ L
Sbjct: 1375 EALLERHQE---HRTEIDARAGTFQAFEQFGQQLLAHGHYAS-PEIKQKLDILDQERADL 1430
Query: 428 REQVSQDLMAL 438
+ Q M L
Sbjct: 1431 EKAWVQRRMML 1441
Score = 36.2 bits (82), Expect = 0.081
Identities = 22/73 (30%), Positives = 39/73 (53%), Gaps = 3/73 (4%)
Query: 181 ITEQQSGAFDRWEMIQAQ--ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAK 238
I+ +++ DRW ++AQ E +KL Q LQQ + D+ I W+ + + + + K
Sbjct: 1522 ISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE-KLQTASDESYK 1580
Query: 239 PPSDIQEIELRVK 251
P++IQ +L K
Sbjct: 1581 DPTNIQLSKLLSK 1593
Score = 35.0 bits (79), Expect = 0.18
Identities = 44/239 (18%), Positives = 92/239 (38%), Gaps = 27/239 (11%)
Query: 169 GNPQQEDGGLAG----ITEQQSGAFDRWEMI--QAQELHNKLKIKQNLQQLNSDISAITT 222
GN E G AG + + + D+W+ + ++ E KLK Q N+ I
Sbjct: 1618 GNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDF 1677
Query: 223 WLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES 282
WL + EA L K D+ + +K+ Q + ++ + +N + + + +
Sbjct: 1678 WLSEVEALLASEDYGK---DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSA 1734
Query: 283 PESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQ 342
++++++ + ++ ++ + S R L +S Q FF+D
Sbjct: 1735 FDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQ-----------FFRDMDDEES 1783
Query: 343 NLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSL 401
W+ K ++ D D + R++ +LE EL +P + + + L
Sbjct: 1784 ----WI---KEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKL 1835
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 46.2 bits (108), Expect = 8e-05
Identities = 51/256 (19%), Positives = 104/256 (40%), Gaps = 25/256 (9%)
Query: 196 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 255
QA +L+ +L + + A W+ + E L ++M D++ ++ R L +
Sbjct: 836 QADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQ 895
Query: 256 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 315
+K T + VN+++ +++ P S E++ L+ W+A Q V R +
Sbjct: 896 EMKTLMTQ---IDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDS 952
Query: 316 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 375
+L + D + S+ W+ + D D ++ +R
Sbjct: 953 ALRVHN-----------YCVDCEETSK----WITD--KTKVVESTKDLGRDLAGIIAIQR 995
Query: 376 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 435
+L LE+++ Q +VD L+ S L+ + E +E + +K L++L + + Q L
Sbjct: 996 KLSGLERDVAAIQARVDALERESQQLM-----DSHPEQKEDIGQRQKHLEELWQGLQQSL 1050
Query: 436 MALQGTQNPASPLPSF 451
+ S L +F
Sbjct: 1051 QGQEDLLGEVSQLQAF 1066
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 46.2 bits (108), Expect = 8e-05
Identities = 51/256 (19%), Positives = 104/256 (40%), Gaps = 25/256 (9%)
Query: 196 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 255
QA +L+ +L + + A W+ + E L ++M D++ ++ R L +
Sbjct: 836 QADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQ 895
Query: 256 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 315
+K T + VN+++ +++ P S E++ L+ W+A Q V R +
Sbjct: 896 EMKTLMTQ---IDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDS 952
Query: 316 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 375
+L + D + S+ W+ + D D ++ +R
Sbjct: 953 ALRVHN-----------YCVDCEETSK----WITD--KTKVVESTKDLGRDLAGIIAIQR 995
Query: 376 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 435
+L LE+++ Q +VD L+ S L+ + E +E + +K L++L + + Q L
Sbjct: 996 KLSGLERDVAAIQARVDALERESQQLM-----DSHPEQKEDIGQRQKHLEELWQGLQQSL 1050
Query: 436 MALQGTQNPASPLPSF 451
+ S L +F
Sbjct: 1051 QGQEDLLGEVSQLQAF 1066
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 46.2 bits (108), Expect = 8e-05
Identities = 68/319 (21%), Positives = 138/319 (43%), Gaps = 47/319 (14%)
Query: 208 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALV 267
Q ++Q N ++A + EL+ L+ + + ++ +EL + R +E L D YKA +
Sbjct: 292 QKVKQENIQLAADARSARAYRDELDSLR--EKANRVERLELELTRCKEKLHDVDFYKARM 349
Query: 268 VSVN------VSSKEFLQTE--------------SPESTELQSRLRQLSLLWEAAQGAVD 307
+ + +K L+ + E+ +L+S+L L L + + ++
Sbjct: 350 EELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIE 409
Query: 308 SWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADP 367
L ++++ K + QLS+N A + +K+ V +
Sbjct: 410 EL---LEENMVLEIAQKQSMNESAHLGWELEQLSKN-----ADLSDASRKSFVFE----- 456
Query: 368 RALLEC-RRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQ 426
L EC +++LEKE Q + L++ SL+++ G C E E++ H + KK+++
Sbjct: 457 --LNECASSRILKLEKENQSLQSTIQGLRDA--SLVLEESGLKCGELEKENHQLSKKIEK 512
Query: 427 LREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETE 486
L+ Q+ ++ + Q + + L E D + +A + R ++ E E++
Sbjct: 513 LQTQLEREKQSNQDLETLSEELIREKEQLQSD------METLKADKARQIKDLEQEKDHL 566
Query: 487 SRVPGSTRPQRSFLSRVVR 505
+R S R +RS +S R
Sbjct: 567 NRAMWSLR-ERSQVSSEAR 584
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 44.7 bits (104), Expect = 2e-04
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 33/243 (13%)
Query: 195 IQAQELHNK-LKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQ-EIELRVKR 252
I +EL K K+++ LQ + S+ S I +K+ + +LE K+ P +Q E + K
Sbjct: 214 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 273
Query: 253 LQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLS--LLWEAAQGAVDSWR 310
LQ +VS+K Q E EL +RL Q +W + + W
Sbjct: 274 LQ----------------SVSAKLQAQVEE---NELWNRLNQQQEEKMWRQEE-KIQEW- 312
Query: 311 GGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRAL 370
+ +Q Q K R + + + ++ Q ++W K RRQ+ + + + R L
Sbjct: 313 ----EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRL 368
Query: 371 LECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQ 430
E E + +EL E+ + + ++E K E+ I +EK E K+ + E+
Sbjct: 369 EEMMWEKEEKIRELEEKMHEQEKIREQEE----KRQEEEKIREQEKRQEQEAKMWRQEEK 424
Query: 431 VSQ 433
+ +
Sbjct: 425 IRE 427
Score = 29.6 bits (65), Expect = 7.6
Identities = 45/265 (16%), Positives = 106/265 (40%), Gaps = 35/265 (13%)
Query: 183 EQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSD 242
E QS + ++ EL N+L +Q + + I W +K + + E K+ +
Sbjct: 273 ELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE-EKIQEWEEKIQEQEE--KIREQEEK 329
Query: 243 IQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLS-LLWEA 301
I+E E +++R +E++ +E ++ + E + ++R+L ++WE
Sbjct: 330 IREQEEKMRRQEEMMW--------------EKEEKMRRQEEMMWEKEEKMRRLEEMMWEK 375
Query: 302 AQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVT 361
+ + Q ++ Q K + + + + Q +W K R Q+ +
Sbjct: 376 EEKIRELEEKMHEQEKIREQEEKRQEEEKIR--EQEKRQEQEAKMWRQEEKIREQEEKIR 433
Query: 362 DP---------------KADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGH 406
+ K + + E+ + E+++ E++ +++ I+
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQ 493
Query: 407 GEDCIEAEEKVHVIEKKLKQLREQV 431
E EEK+H E+K+++ E++
Sbjct: 494 EEKVWRQEEKMHDQEEKIREQEEKM 518
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 44.3 bits (103), Expect = 3e-04
Identities = 49/247 (19%), Positives = 108/247 (43%), Gaps = 34/247 (13%)
Query: 161 KEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQA--QELHNKLKIKQNLQQLNSDIS 218
KEG ++++ P+ E A + E+ +G WE++++ Q +L + +
Sbjct: 1322 KEGMQLISEKPETE----AVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1377
Query: 219 AITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFL 278
+ WL E++++ K D+ + + +K+ Q + + +
Sbjct: 1378 DLDKWLHGLESQIQSDDYGK---DLTSVNILLKKQQML------------------ENQM 1416
Query: 279 QTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFH 338
+ E ELQS+ + LS ++ VDS R ++ M+ + ++L K+ H
Sbjct: 1417 EVRKKEIEELQSQAQALSQEGKSTD-EVDSKRLTVQTKFMELLEPLNERKHNLLASKEIH 1475
Query: 339 QLSQNL---LLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQ 395
Q ++++ +LW+ R A TD + + + ++ L+KE+ QP++D +
Sbjct: 1476 QFNRDVEDEILWVGE---RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIF 1532
Query: 396 EISNSLL 402
E S +++
Sbjct: 1533 ERSQNIV 1539
Score = 37.4 bits (85), Expect = 0.036
Identities = 45/223 (20%), Positives = 87/223 (39%), Gaps = 24/223 (10%)
Query: 196 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 255
+ ++ H +L+ QQ D + W+ +E EL M+ K + + + +K+ Q
Sbjct: 1567 ETEKRHRRLEEAHRAQQYYFDAAEAEAWM--SEQELYMMSEEKAKDEQSAVSM-LKKHQI 1623
Query: 256 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGL-- 313
+ +A + Y V ++ +S+ + PES + R ++ L+ + + RG L
Sbjct: 1624 LEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDE 1683
Query: 314 RQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLEC 373
R L Q ++ L Q W+A + + L E
Sbjct: 1684 RHRLFQLN-------------REVDDLEQ----WIAEREVVAGSHELGQDYEHVTMLQER 1726
Query: 374 RRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEK 416
RE + + Q +VD + +++ L+ GH + AE K
Sbjct: 1727 FREFARDTGNI--GQERVDTVNHLADELINSGHSDAATIAEWK 1767
Score = 32.0 bits (71), Expect = 1.5
Identities = 44/239 (18%), Positives = 91/239 (38%), Gaps = 28/239 (11%)
Query: 197 AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL--Q 254
A EL +LK ++LQ+ D ++ W+ E + A+ S + L K L Q
Sbjct: 1251 ASELLMRLKDNRDLQKFLQDCQELSLWIN------EKMLTAQDMSYDEARNLHSKWLKHQ 1304
Query: 255 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 314
+ + K + + + + + ++ +L L +WE +
Sbjct: 1305 AFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ------- 1357
Query: 315 QSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECR 374
+K + D + F Q +L WL +++ Q LL
Sbjct: 1358 --------TKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILL--- 1406
Query: 375 RELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 433
++ LE ++ R+ +++ LQ + +L +G D E + K ++ K +L E +++
Sbjct: 1407 KKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTD--EVDSKRLTVQTKFMELLEPLNE 1463
Score = 30.8 bits (68), Expect = 3.4
Identities = 56/294 (19%), Positives = 118/294 (40%), Gaps = 37/294 (12%)
Query: 157 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQ--NLQQLN 214
+D KE ++ + +P Q L+ + E D WE ++ + + + + LQQ
Sbjct: 1000 SDLQKEAEKLESEHPDQAQAILSRLAEIS----DVWEEMKTTLKNREASLGEASKLQQFL 1055
Query: 215 SDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSS 274
D+ +WL +T+ + M P+ + E E + + + I D Y+ +
Sbjct: 1056 RDLDDFQSWLSRTQTAIASEDM---PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG 1112
Query: 275 KEFLQTES-PESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLF 333
+ Q ++ + L+ RL+ L W ++ + L QS Q + +++
Sbjct: 1113 EMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFL 1172
Query: 334 FKDFHQLSQNLL---LWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQ 390
+ L+ + L A A ++Q+ +T A+ + +
Sbjct: 1173 NNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDAN---------------------EEK 1211
Query: 391 VDMLQEISNSLLIKGH-GEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQN 443
++ + E L+ G+ D I +EKV I+ + ++ RE S+ LM L+ ++
Sbjct: 1212 INAVVETGRRLVSDGNINSDRI--QEKVDSIDDRHRKNRETASELLMRLKDNRD 1263
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 44.3 bits (103), Expect = 3e-04
Identities = 49/247 (19%), Positives = 108/247 (43%), Gaps = 34/247 (13%)
Query: 161 KEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQA--QELHNKLKIKQNLQQLNSDIS 218
KEG ++++ P+ E A + E+ +G WE++++ Q +L + +
Sbjct: 1335 KEGMQLISEKPETE----AVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1390
Query: 219 AITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFL 278
+ WL E++++ K D+ + + +K+ Q + + +
Sbjct: 1391 DLDKWLHGLESQIQSDDYGK---DLTSVNILLKKQQML------------------ENQM 1429
Query: 279 QTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFH 338
+ E ELQS+ + LS ++ VDS R ++ M+ + ++L K+ H
Sbjct: 1430 EVRKKEIEELQSQAQALSQEGKSTD-EVDSKRLTVQTKFMELLEPLNERKHNLLASKEIH 1488
Query: 339 QLSQNL---LLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQ 395
Q ++++ +LW+ R A TD + + + ++ L+KE+ QP++D +
Sbjct: 1489 QFNRDVEDEILWVGE---RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIF 1545
Query: 396 EISNSLL 402
E S +++
Sbjct: 1546 ERSQNIV 1552
Score = 37.4 bits (85), Expect = 0.036
Identities = 45/223 (20%), Positives = 87/223 (39%), Gaps = 24/223 (10%)
Query: 196 QAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQE 255
+ ++ H +L+ QQ D + W+ +E EL M+ K + + + +K+ Q
Sbjct: 1580 ETEKRHRRLEEAHRAQQYYFDAAEAEAWM--SEQELYMMSEEKAKDEQSAVSM-LKKHQI 1636
Query: 256 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGL-- 313
+ +A + Y V ++ +S+ + PES + R ++ L+ + + RG L
Sbjct: 1637 LEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDE 1696
Query: 314 RQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLEC 373
R L Q ++ L Q W+A + + L E
Sbjct: 1697 RHRLFQLN-------------REVDDLEQ----WIAEREVVAGSHELGQDYEHVTMLQER 1739
Query: 374 RRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEK 416
RE + + Q +VD + +++ L+ GH + AE K
Sbjct: 1740 FREFARDTGNI--GQERVDTVNHLADELINSGHSDAATIAEWK 1780
Score = 32.0 bits (71), Expect = 1.5
Identities = 44/239 (18%), Positives = 91/239 (38%), Gaps = 28/239 (11%)
Query: 197 AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL--Q 254
A EL +LK ++LQ+ D ++ W+ E + A+ S + L K L Q
Sbjct: 1264 ASELLMRLKDNRDLQKFLQDCQELSLWIN------EKMLTAQDMSYDEARNLHSKWLKHQ 1317
Query: 255 EILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR 314
+ + K + + + + + ++ +L L +WE +
Sbjct: 1318 AFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ------- 1370
Query: 315 QSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECR 374
+K + D + F Q +L WL +++ Q LL
Sbjct: 1371 --------TKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILL--- 1419
Query: 375 RELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQ 433
++ LE ++ R+ +++ LQ + +L +G D E + K ++ K +L E +++
Sbjct: 1420 KKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTD--EVDSKRLTVQTKFMELLEPLNE 1476
Score = 30.8 bits (68), Expect = 3.4
Identities = 56/294 (19%), Positives = 118/294 (40%), Gaps = 37/294 (12%)
Query: 157 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQAQELHNKLKIKQ--NLQQLN 214
+D KE ++ + +P Q L+ + E D WE ++ + + + + LQQ
Sbjct: 1013 SDLQKEAEKLESEHPDQAQAILSRLAEIS----DVWEEMKTTLKNREASLGEASKLQQFL 1068
Query: 215 SDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSS 274
D+ +WL +T+ + M P+ + E E + + + I D Y+ +
Sbjct: 1069 RDLDDFQSWLSRTQTAIASEDM---PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG 1125
Query: 275 KEFLQTES-PESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLF 333
+ Q ++ + L+ RL+ L W ++ + L QS Q + +++
Sbjct: 1126 EMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFL 1185
Query: 334 FKDFHQLSQNLL---LWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQ 390
+ L+ + L A A ++Q+ +T A+ + +
Sbjct: 1186 NNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDAN---------------------EEK 1224
Query: 391 VDMLQEISNSLLIKGH-GEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQN 443
++ + E L+ G+ D I +EKV I+ + ++ RE S+ LM L+ ++
Sbjct: 1225 INAVVETGRRLVSDGNINSDRI--QEKVDSIDDRHRKNRETASELLMRLKDNRD 1276
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 42.7 bits (99), Expect = 9e-04
Identities = 53/242 (21%), Positives = 103/242 (42%), Gaps = 17/242 (7%)
Query: 195 IQAQELHNK-LKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQ-EIELRVKR 252
I +EL K K+++ LQ + S+ S I +K+ + +LE K+ P +Q E + K
Sbjct: 214 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 273
Query: 253 LQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA-QGAVDSWRG 311
LQ + + + V E + + E R + WE Q + R
Sbjct: 274 LQSV--------SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 325
Query: 312 GLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALL 371
++ ++ Q K R + ++++ K+ Q ++W K RRQ+ + + + R
Sbjct: 326 --QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE 383
Query: 372 ECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQV 431
E E + +EL E+ + + ++E K E+ I +EK E K+ + E++
Sbjct: 384 EMMWEKEEKIRELEEKMHEQEKIREQEE----KRQEEEKIREQEKRQEQEAKMWRQEEKI 439
Query: 432 SQ 433
+
Sbjct: 440 RE 441
Score = 30.8 bits (68), Expect = 3.4
Identities = 44/264 (16%), Positives = 105/264 (39%), Gaps = 15/264 (5%)
Query: 181 ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAI----TTWLKKTEAELEMLKM 236
I EQ+ + + E I QE + + +Q +++ I W +K + + K+
Sbjct: 446 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKI 505
Query: 237 AKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLS 296
K + E +++ +E ++ + + +E E E + ++ +
Sbjct: 506 RKQEEKVWRQEEKIREQEEKIREQEE--------KMWRQEEKIREQEEMWREEEKMHEQE 557
Query: 297 LLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQ 356
+WE + + ++ ++ Q K + + + ++ + Q +W K R Q
Sbjct: 558 KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQ 617
Query: 357 KAHVTDPKADPRALLECRRELMQLEKELVERQ-PQVDMLQEISNSLLIKGHGEDCIEAEE 415
+ + + + R E RE ++ +E E+ Q + + E + + E EE
Sbjct: 618 EEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKM--QEQEETMWRQEE 675
Query: 416 KVHVIEKKLKQLREQVSQDLMALQ 439
K+ EKK+++ E++ + +Q
Sbjct: 676 KIREQEKKIREQEEKIREQEEMMQ 699
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 42.4 bits (98), Expect = 0.001
Identities = 62/242 (25%), Positives = 101/242 (41%), Gaps = 29/242 (11%)
Query: 197 AQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIEL-RVKRLQE 255
A LH+ LQ+ +SA++TW KK + +E L + D +EL R E
Sbjct: 130 AGRLHHSWHFAGELQRA---LSAVSTWHKKADRYIEELTKER---DALSLELYRNTITNE 183
Query: 256 ILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQ 315
LK N +E L+ E +E+Q +++L E A+ + + Q
Sbjct: 184 ELK----------KKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ 233
Query: 316 SLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 375
M Q + R + + ++ Q L K R Q+ + + + L E +
Sbjct: 234 EEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM---RRQEKRLREQEK 290
Query: 376 ELMQLEKELVER---QPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKL----KQLR 428
EL + EKEL E+ + Q + +QE + E E EEK+ E++L KQ+R
Sbjct: 291 ELREQEKELREQKKLREQEEQMQEQEEKMW--EQEEKMREQEEKMWRQEERLWEQEKQMR 348
Query: 429 EQ 430
EQ
Sbjct: 349 EQ 350
>gi|24233517 IKK interacting protein isoform 1 [Homo sapiens]
Length = 377
Score = 42.4 bits (98), Expect = 0.001
Identities = 72/311 (23%), Positives = 139/311 (44%), Gaps = 56/311 (18%)
Query: 177 GLAGITEQQSGAFDRWEMIQAQELHNKLKIKQN-LQQLNSDISAITTWLKKTEAELE--- 232
GLA QQS F + E + LK++ N QQL S IS I+ L+ TE+ L+
Sbjct: 57 GLAWFVFQQSEKFAKVE-----NQYQLLKLETNEFQQLQSKISLISEKLESTESILQEAT 111
Query: 233 -----MLKMAKPPSDIQEI--------ELRVKRLQEILKAF----DTYKALVVSVNVSS- 274
M + + S++Q+I E+ +R+Q + + F D +K + +N+++
Sbjct: 112 SSMSLMTQFEQEVSNLQDIMHDIQNNEEVLTQRMQSLNEKFQNITDFWKRSLEEMNINTD 171
Query: 275 ---KEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR-------QSLMQCQ--- 321
E S + ++ S +++ LL E + DS +R + L++ +
Sbjct: 172 IFKSEAKHIHSQVTVQINSAEQEIKLLTERLKDLEDSTLRNIRTVKRQEEEDLLRVEEQL 231
Query: 322 GSKTR------PRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRR 375
GS T+ LF +D L+ L + K K H+ ++ ++L +
Sbjct: 232 GSDTKAIEKLEEEQHALFARD-EDLTNKLSDY--EPKVEECKTHLPTIESAIHSVLRVSQ 288
Query: 376 ELMQLEKELVERQPQV-----DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQ 430
+L++ EK++ + Q+ DML+ +S + ++ E I+ + + ++ +L L+E+
Sbjct: 289 DLIETEKKMEDLTMQMFNMEDDMLKAVSEIMEMQKTLEG-IQYDNSILKMQNELDILKEK 347
Query: 431 VSQDLMALQGT 441
V D +A T
Sbjct: 348 V-HDFIAYSST 357
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 42.0 bits (97), Expect = 0.001
Identities = 52/245 (21%), Positives = 105/245 (42%), Gaps = 16/245 (6%)
Query: 195 IQAQELHNK-LKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQ-EIELRVKR 252
I +EL K K+++ LQ + S+ S I +K+ + +LE K+ P +Q E + K
Sbjct: 275 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 334
Query: 253 LQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA-QGAVDSWRG 311
LQ + + + V E + + E R + WE Q + R
Sbjct: 335 LQSV--------SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 386
Query: 312 GLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALL 371
++ ++ Q K R + ++++ K+ Q ++W K RRQ+ + + + R L
Sbjct: 387 --QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 444
Query: 372 ECRRELMQLEKELVERQPQVDMLQE---ISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 428
E E ++ ++ +RQ + + ++ + E E EEK+ E+K+ +
Sbjct: 445 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQE 504
Query: 429 EQVSQ 433
E++ +
Sbjct: 505 EKIHE 509
Score = 29.3 bits (64), Expect = 9.9
Identities = 43/257 (16%), Positives = 105/257 (40%), Gaps = 18/257 (7%)
Query: 183 EQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSD 242
E QS + ++ EL N+L +Q + + I W +K + + E K+ +
Sbjct: 334 ELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE-EKIQEWEEKIQEQEE--KIREQEEK 390
Query: 243 IQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA 302
I+E E +++R +E++ + + +E ++ + E + ++R+L
Sbjct: 391 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 450
Query: 303 QGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQL--------SQNLLLWLASAKNR 354
+ + RQ + + + R + ++ ++ Q +W K
Sbjct: 451 EKIREQEEK--RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIH 508
Query: 355 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 414
Q+ + K + + + E ++ ++E+ ++ ++ +E I+ E E
Sbjct: 509 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEE-----KIRKQEEKMWRQE 563
Query: 415 EKVHVIEKKLKQLREQV 431
EK+H E+K+++ E+V
Sbjct: 564 EKMHDQEEKIREQEEKV 580
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin
(with transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 40.8 bits (94), Expect = 0.003
Identities = 71/317 (22%), Positives = 134/317 (42%), Gaps = 57/317 (17%)
Query: 199 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILK 258
E+ + +KQ LQ+ IS + L +T+AE ++ + E ++R+ E+L+
Sbjct: 181 EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHE-DELLQ 239
Query: 259 AFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLR-QSL 317
L T++ TE+Q +LR L E + +S G + L
Sbjct: 240 -------------------LVTQADVETEMQQKLRVLQRKLEEHE---ESLVGRAQVVDL 277
Query: 318 MQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL 377
+Q + + R+ +L QL Q A++ + V + + + LLE
Sbjct: 278 LQQELTAAEQRNQIL----SQQLQQ------MEAEHNTLRNTVETEREESKILLE----- 322
Query: 378 MQLEKELVERQPQVDMLQEISNSLL--IKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDL 435
++E E+ ER+ LQE + LL + G+ E E + +E+K K E+ + +
Sbjct: 323 -KMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHI 381
Query: 436 MALQGT-QNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETESRVPGSTR 494
++LQ T Q S + + +S + K +AV++ + ++ E ++ ++
Sbjct: 382 LSLQKTGQELQSACDALKDQNS---------KLLQDKNEQAVQSAQTIQQLEDQLQQKSK 432
Query: 495 PQRSFLSRVVRAALPLQ 511
FL+R LPLQ
Sbjct: 433 EISQFLNR-----LPLQ 444
Score = 30.0 bits (66), Expect = 5.8
Identities = 44/230 (19%), Positives = 91/230 (39%), Gaps = 40/230 (17%)
Query: 287 ELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLL 346
++Q L +++ L E A+ D L L + GS DV + ++L ++ +
Sbjct: 1900 QIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMK 1959
Query: 347 WLASAKNRRQKAHVTDPKADPRALLECRRELMQ-----------------LEKELVERQP 389
L + ++ K + E R+E ++ L++ L E+Q
Sbjct: 1960 NLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ 2019
Query: 390 QVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQL---REQVSQDL--------MAL 438
+V LQ+ DCI +EK+ +E+ +K L + + +DL A+
Sbjct: 2020 EVKQLQK------------DCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAV 2067
Query: 439 QGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETESR 488
+ + + L SF + Q A V A K + +++ + +++ +
Sbjct: 2068 EHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMK 2117
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,339,124
Number of Sequences: 37866
Number of extensions: 1298157
Number of successful extensions: 6273
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 275
Number of HSP's that attempted gapping in prelim test: 5754
Number of HSP's gapped (non-prelim): 733
length of query: 556
length of database: 18,247,518
effective HSP length: 107
effective length of query: 449
effective length of database: 14,195,856
effective search space: 6373939344
effective search space used: 6373939344
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.