Guide to the Human Genome
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Search of human proteins with 33457322

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|33457322 SVOP-like isoform 2 [Homo sapiens]
         (340 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33457322 SVOP-like isoform 2 [Homo sapiens]                        663   0.0  
gi|213021148 SVOP-like isoform 1 [Homo sapiens]                       654   0.0  
gi|24308167 SV2 related protein [Homo sapiens]                        239   3e-63
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...    96   4e-20
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...    96   4e-20
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...    94   1e-19
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...    94   1e-19
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]        92   7e-19
gi|166064021 solute carrier family 22 (organic anion transporter...    89   4e-18
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]            88   1e-17
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]           87   2e-17
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]            83   3e-16
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...    82   7e-16
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]           82   7e-16
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]        77   2e-14
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]         75   8e-14
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]           75   1e-13
gi|157426885 organic cation transporter like 4 [Homo sapiens]          71   1e-12
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...    69   8e-12
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...    69   8e-12
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...    58   1e-08
gi|73695465 synaptic vesicle glycoprotein 2C [Homo sapiens]            57   2e-08
gi|216548223 synaptic vesicle glycoprotein 2 [Homo sapiens]            56   5e-08
gi|7662270 synaptic vesicle protein 2B homolog [Homo sapiens]          56   5e-08
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]           55   9e-08
gi|47933389 solute carrier family 2, member 9 protein isoform 2 ...    52   8e-07
gi|47933387 solute carrier family 2, member 9 protein isoform 1 ...    52   8e-07
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]        52   8e-07
gi|223029432 solute carrier family 2 (facilitated glucose transp...    51   2e-06
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]           49   8e-06

>gi|33457322 SVOP-like isoform 2 [Homo sapiens]
          Length = 340

 Score =  663 bits (1711), Expect = 0.0
 Identities = 340/340 (100%), Positives = 340/340 (100%)

Query: 1   MAAGRLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPG 60
           MAAGRLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPG
Sbjct: 1   MAAGRLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPG 60

Query: 61  IILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADL 120
           IILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADL
Sbjct: 61  IILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADL 120

Query: 121 LDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQS 180
           LDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQS
Sbjct: 121 LDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQS 180

Query: 181 PCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICT 240
           PCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICT
Sbjct: 181 PCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICT 240

Query: 241 SSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQV 300
           SSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQV
Sbjct: 241 SSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQV 300

Query: 301 LMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQIK 340
           LMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQIK
Sbjct: 301 LMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQIK 340


>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
          Length = 492

 Score =  654 bits (1687), Expect = 0.0
 Identities = 335/335 (100%), Positives = 335/335 (100%)

Query: 6   LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIV 65
           LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIV
Sbjct: 158 LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIV 217

Query: 66  AFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKY 125
           AFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKY
Sbjct: 218 AFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKY 277

Query: 126 LRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCH 185
           LRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCH
Sbjct: 278 LRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCH 337

Query: 186 MFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGL 245
           MFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGL
Sbjct: 338 MFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGL 397

Query: 246 IGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSAS 305
           IGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSAS
Sbjct: 398 IGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSAS 457

Query: 306 ILGALCLFSSVCVVCAISAFTLPIETKGRALQQIK 340
           ILGALCLFSSVCVVCAISAFTLPIETKGRALQQIK
Sbjct: 458 ILGALCLFSSVCVVCAISAFTLPIETKGRALQQIK 492


>gi|24308167 SV2 related protein [Homo sapiens]
          Length = 548

 Score =  239 bits (609), Expect = 3e-63
 Identities = 122/328 (37%), Positives = 195/328 (59%), Gaps = 7/328 (2%)

Query: 11  EFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFI 70
           EFLP K R   + L +VFW  G++  + LA  ++P++GWRWL+ ++++P ++  V   ++
Sbjct: 199 EFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLILSAVPLLLFAVLCFWL 258

Query: 71  PESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKYLRTTL 130
           PESAR++V +GN   A+ATL+R+A  N + MP GKL+    E RG+  DL    +  TTL
Sbjct: 259 PESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLIISRQEDRGKMRDLFTPHFRWTTL 318

Query: 131 QIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPS 190
            +W IW   +F+YYG++L + EL +   VCG  S    V       E++    C   +  
Sbjct: 319 LLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAV-------EAKCSLACEYLSEE 371

Query: 191 DYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLF 250
           DY  ++ +T+ E     + +  I+ LGR+ ++++     +   LLL IC     L   LF
Sbjct: 372 DYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLLFICVGRNVLTLLLF 431

Query: 251 MLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGAL 310
           + RA ++  F   Y+YT EVYPT  RALG+GT   + R+GA++ PFI+QV++ +S+   L
Sbjct: 432 IARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTL 491

Query: 311 CLFSSVCVVCAISAFTLPIETKGRALQQ 338
            ++S  C++ A+++  LPIETKGR LQ+
Sbjct: 492 AVYSGCCLLAALASCFLPIETKGRGLQE 519


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score = 96.3 bits (238), Expect = 4e-20
 Identities = 87/344 (25%), Positives = 156/344 (45%), Gaps = 53/344 (15%)

Query: 8   IKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAF 67
           ++ E+L  ++R     LS  FW  G ++++ L   +I    WRWL+   ++P    I++ 
Sbjct: 219 LELEWLDVEHRTVAGVLSSTFW-TGGVMLLALVGYLIRD--WRWLLLAVTLPCAPGILSL 275

Query: 68  KFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEK---------RGRFA 118
            ++PESAR+ ++ G+ + A   L   A++N   + E    +  + K         R  + 
Sbjct: 276 WWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYL 335

Query: 119 DLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGE 177
           DL     LR  +L   V+W G++F+YYG+ L  + L                        
Sbjct: 336 DLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGL------------------------ 371

Query: 178 SQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFF---L 234
                       + Y+T ++    E+    L  L + + GRRL+ + T+  TAL F   L
Sbjct: 372 ----------GLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRL 421

Query: 235 LLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVA 294
           L++    S   +    M +A   A F T Y++T+E+YPT +R  GMG +  + R+G  +A
Sbjct: 422 LVSSDMKSWSTV-LAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA 480

Query: 295 PFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQ 338
           P ++ +L    +      +  + ++ A +A  LP ET+   L +
Sbjct: 481 P-LAALLDGVWLSLPKLTYGGIALLAAGTALLLP-ETRQAQLPE 522


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score = 96.3 bits (238), Expect = 4e-20
 Identities = 87/344 (25%), Positives = 156/344 (45%), Gaps = 53/344 (15%)

Query: 8   IKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAF 67
           ++ E+L  ++R     LS  FW  G ++++ L   +I    WRWL+   ++P    I++ 
Sbjct: 217 LELEWLDVEHRTVAGVLSSTFW-TGGVMLLALVGYLIRD--WRWLLLAVTLPCAPGILSL 273

Query: 68  KFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEK---------RGRFA 118
            ++PESAR+ ++ G+ + A   L   A++N   + E    +  + K         R  + 
Sbjct: 274 WWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYL 333

Query: 119 DLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGE 177
           DL     LR  +L   V+W G++F+YYG+ L  + L                        
Sbjct: 334 DLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGL------------------------ 369

Query: 178 SQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFF---L 234
                       + Y+T ++    E+    L  L + + GRRL+ + T+  TAL F   L
Sbjct: 370 ----------GLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRL 419

Query: 235 LLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVA 294
           L++    S   +    M +A   A F T Y++T+E+YPT +R  GMG +  + R+G  +A
Sbjct: 420 LVSSDMKSWSTV-LAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA 478

Query: 295 PFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQ 338
           P ++ +L    +      +  + ++ A +A  LP ET+   L +
Sbjct: 479 P-LAALLDGVWLSLPKLTYGGIALLAAGTALLLP-ETRQAQLPE 520


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 89/346 (25%), Positives = 147/346 (42%), Gaps = 55/346 (15%)

Query: 6   LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIV 65
           + +  E++P   R  +  L    +  G  L+ G+A  +     WR L  + S P     +
Sbjct: 207 MTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPH---WRHLQLLVSAPFFAFFI 263

Query: 66  AFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEK-----------R 114
              F  ESAR++ S+G     L  L+RVA++N       KL   VL             +
Sbjct: 264 YSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQ 323

Query: 115 GRFADLLDAKYLRTT-LQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGG 173
               +LL    LR   L + ++W   SFAYYG+++        DL               
Sbjct: 324 ASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM--------DL--------------- 360

Query: 174 DSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFF 233
                        F  S Y   +I    ++    +  L IN LGRR +    +    +  
Sbjct: 361 -----------QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 234 LLLNICTSSAGLI--GFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGA 291
           LL  +      ++      + +  +AA+FN +++YT E+YPT +R  GMG   ++ R+G+
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469

Query: 292 MVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPI-ETKGRAL 336
           +V+P +S   M+A +  ++ LF    V  A SA T+ + ET G+ L
Sbjct: 470 IVSPLVS---MTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPL 512


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 89/346 (25%), Positives = 147/346 (42%), Gaps = 55/346 (15%)

Query: 6   LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIV 65
           + +  E++P   R  +  L    +  G  L+ G+A  +     WR L  + S P     +
Sbjct: 207 MTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPH---WRHLQLLVSAPFFAFFI 263

Query: 66  AFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEK-----------R 114
              F  ESAR++ S+G     L  L+RVA++N       KL   VL             +
Sbjct: 264 YSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQ 323

Query: 115 GRFADLLDAKYLRTT-LQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGG 173
               +LL    LR   L + ++W   SFAYYG+++        DL               
Sbjct: 324 ASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM--------DL--------------- 360

Query: 174 DSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFF 233
                        F  S Y   +I    ++    +  L IN LGRR +    +    +  
Sbjct: 361 -----------QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 234 LLLNICTSSAGLI--GFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGA 291
           LL  +      ++      + +  +AA+FN +++YT E+YPT +R  GMG   ++ R+G+
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469

Query: 292 MVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPI-ETKGRAL 336
           +V+P +S   M+A +  ++ LF    V  A SA T+ + ET G+ L
Sbjct: 470 IVSPLVS---MTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPL 512


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score = 92.0 bits (227), Expect = 7e-19
 Identities = 87/297 (29%), Positives = 129/297 (43%), Gaps = 66/297 (22%)

Query: 28  FW-LAGSL----LIIGLASVIIPTI---GWRWLIRVASIPGIILIVAFKFIPESARFNVS 79
           +W LAGS+      +G+A   +       WR L  + ++ G ++ +   FIPES R+  S
Sbjct: 195 YWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYS 254

Query: 80  TGNTRAALATLERVAKMNRSVMPEGKLVEPV---LEKRGRFADLLDAKYLRT-TLQIWVI 135
            G    A   L  +AK NR +     L  P      + G F DL   + L   TL +  I
Sbjct: 255 QGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFI 314

Query: 136 WLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTM 195
           W   S  YYG+ L++ +L                  GG                S Y  +
Sbjct: 315 WFVCSLVYYGLTLSAGDL------------------GG----------------SIYANL 340

Query: 196 IISTIGEIALNPLNILGIN--FLGRRLSLSITM-----GCTALFFL--------LLNICT 240
            +S + EI   PL I  IN  + GR+ +LS  +      C  + FL           + +
Sbjct: 341 ALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNS 400

Query: 241 SSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFI 297
            S  L+G L      ++A FN VYIYT+E+YPT +R +G+GT     R+G ++APFI
Sbjct: 401 HSLSLLGKL-----TISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFI 452


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score = 89.4 bits (220), Expect = 4e-18
 Identities = 84/341 (24%), Positives = 147/341 (43%), Gaps = 41/341 (12%)

Query: 1   MAAGRLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPG 60
           ++   + + TE++   +R   + L+Q  +  G +++ GLA        WR L    + PG
Sbjct: 205 LSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFR---NWRLLQITGTAPG 261

Query: 61  IILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADL 120
           ++L   F  +PESAR+ ++ G    A+  +++ A +NR  +    + + V EK G   + 
Sbjct: 262 LLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTGPSGNA 321

Query: 121 LD----AKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSG 176
           LD     +  + TL I+ +W   S  YYG+ L   +               V +T    G
Sbjct: 322 LDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDF-----------GLDVYLTQLIFG 370

Query: 177 ESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLL 236
             + P  C             S +G + L  L  + I F+   L + +TM          
Sbjct: 371 AVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTM---------- 420

Query: 237 NICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPF 296
                   ++G     +   AA F   Y+Y+AE++PT +R  GMG  G   RIG ++ P 
Sbjct: 421 ------LAVVG-----KMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPL 469

Query: 297 ISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQ 337
           +  +    + L  L ++ S+ +V  +    LP ET G+ L+
Sbjct: 470 VILLGEYHAALPML-IYGSLPIVAGLLCTLLP-ETHGQGLK 508


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 81/341 (23%), Positives = 155/341 (45%), Gaps = 57/341 (16%)

Query: 7   IIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVA 66
           ++ TE L    R     L    + A   +++ L +  I    WR L+   ++PG++ +  
Sbjct: 216 VLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRD--WRMLLVALTMPGVLCVAL 273

Query: 67  FKFIPESARFNVSTGNTRAALATLERVAKMNRSVMP----EGKLVEPVLEKRGRFADLLD 122
           + FIPES R+ +S G    A   + + AK N  V+P    +   ++ +  K+ +  ++LD
Sbjct: 274 WWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILD 333

Query: 123 AKYLRT------TLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSG 176
              LRT      T+   ++W+ IS  Y+G+ L +  L                      G
Sbjct: 334 L--LRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNL---------------------HG 370

Query: 177 ESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLS--ITMGCTALFFL 234
           +    C+             +S + E+    L  L + +L RR S++  + +G + L F+
Sbjct: 371 DIFVNCF-------------LSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFM 417

Query: 235 LLNICTSSAGLIGFLFMLRAL-VAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMV 293
            L +      L   L M+    V A F+ VY+YTAE+YPT +R +G+G S +  R+G+++
Sbjct: 418 QL-VPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL 476

Query: 294 APFISQV-----LMSASILGALCLFSSVCVVCAISAFTLPI 329
           +P+   +      +   ++G+L + +++  +    +F  P+
Sbjct: 477 SPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPL 517


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 78/309 (25%), Positives = 130/309 (42%), Gaps = 57/309 (18%)

Query: 6   LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIV 65
           +I+  E++PT+ R  M       +  G  ++ GLA  I     WRWL    SIP  +  +
Sbjct: 195 VILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQ---WRWLQLTVSIPFFVFFL 251

Query: 66  AFKFIPESARFNVSTGNTRAALATLERVAKMN-RSVMPEGKLVEPVLEKRGRFADLLDAK 124
           +  + PES R+ V +G +  AL  L RVA  N +    E   +E +     +   L  AK
Sbjct: 252 SSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAK 311

Query: 125 YL-----------RTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGG 173
           Y            R T  + + W    FAYY + +   E                     
Sbjct: 312 YTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEE--------------------- 350

Query: 174 DSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITM-----GC 228
                        F  + Y   II    ++    + IL +++LGR  + +  +       
Sbjct: 351 -------------FGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAI 397

Query: 229 TALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCR 288
            AL F+ L++ T    L  F    +  ++++F+ +++YT+E+YPT +R  GMG S    R
Sbjct: 398 LALTFVPLDLQTVRTVLAVF---GKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTR 454

Query: 289 IGAMVAPFI 297
           +G+MV+P +
Sbjct: 455 VGSMVSPLV 463


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 87/350 (24%), Positives = 142/350 (40%), Gaps = 66/350 (18%)

Query: 7   IIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVA 66
           I+ TEF+  +YR  +    QV +  G L++ G+A  +     WRWL    ++P    ++ 
Sbjct: 223 ILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPH---WRWLQFTVALPNFFFLLY 279

Query: 67  FKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGR-----FADLL 121
           +  IPES R+ +S      A+  ++ +AK N   +P       + E+ G+     F DL+
Sbjct: 280 YWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLV 339

Query: 122 DAKYLRT-TLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQS 180
               +R  T+ +   W   S  Y G+I+                                
Sbjct: 340 RTPQIRKHTMILMYNWFTSSVLYQGLIM-------------------------------- 367

Query: 181 PCYCHMFAPSD--YRTMIISTIGEIALNPLNILGINFLGRRL-----SLSITMGCTALFF 233
               HM    D  Y     S + E     + IL I+ +GRR      ++     C A  F
Sbjct: 368 ----HMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVF 423

Query: 234 L-----LLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCR 288
           +      L I  S  G +G        +   +  V +  AE+YPT +R LG+    S+C 
Sbjct: 424 IPGDLQWLKIIISCLGRMG--------ITMAYEIVCLVNAELYPTFIRNLGVHICSSMCD 475

Query: 289 IGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQ 338
           IG ++ PF+   L +  +   L +F  + +V       LP ETKG+AL +
Sbjct: 476 IGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLP-ETKGKALPE 524


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score = 82.0 bits (201), Expect = 7e-16
 Identities = 93/354 (26%), Positives = 147/354 (41%), Gaps = 67/354 (18%)

Query: 3   AGRLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGII 62
           AG  +I TEF+ +  R  +  + Q+ +  G + + GLA  +     WRWL    S+P  +
Sbjct: 219 AGYTLI-TEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPH---WRWLQLAVSLPTFL 274

Query: 63  LIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEG----KLVEPVLEKRG-RF 117
            ++ +  +PES R+ +S      A+  ++ +A+ N  + P       L E V EK    F
Sbjct: 275 FLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSF 334

Query: 118 ADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSG 176
           ADL     LR  T  +  +W   S  Y G+IL                            
Sbjct: 335 ADLFRTPRLRKRTFILMYLWFTDSVLYQGLIL---------------------------- 366

Query: 177 ESQSPCYCHMFAPSD--YRTMIISTIGEIALNPLNILGINFLGRRLSLSIT-----MGCT 229
                   HM A S   Y   + S + EI    + ++ I+ +GR   ++++       C 
Sbjct: 367 --------HMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACL 418

Query: 230 ALFFL-----LLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSG 284
            + F+      LNI     G +G    ++ +   N        AE+YPT +R LG+    
Sbjct: 419 VMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVN--------AELYPTFVRNLGVMVCS 470

Query: 285 SLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQ 338
           SLC IG ++ PFI   L        L LF+ + ++ A     LP ETKG AL +
Sbjct: 471 SLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLP-ETKGVALPE 523


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score = 82.0 bits (201), Expect = 7e-16
 Identities = 84/343 (24%), Positives = 144/343 (41%), Gaps = 54/343 (15%)

Query: 7   IIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVA 66
           +I TE + +K R  +  + Q+F+  G +++ G+A   IP   W+ +    ++P  + ++ 
Sbjct: 228 VIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIA-YFIPN--WQGIQLAITLPSFLFLLY 284

Query: 67  FKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKR---GRFADLLDA 123
           +  +PES R+ ++      AL  L R+AK N   +        V ++      F DL+  
Sbjct: 285 YWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPSFLDLVRT 344

Query: 124 KYLRT-TLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPC 182
             +R  TL +   W   +  Y G+++                     + GG+        
Sbjct: 345 PQMRKCTLILMFAWFTSAVVYQGLVMRLG------------------IIGGNL------- 379

Query: 183 YCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSIT-----MGCTALFFLLLN 237
                    Y    IS + E+    L +L I  LGRRL  + +     + C    FL   
Sbjct: 380 ---------YIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEG 430

Query: 238 IC--TSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAP 295
           I    ++   +G L +  A     F  VY+  +E+YPTT+R  G+     LC  G ++AP
Sbjct: 431 IAWLRTTVATLGRLGITMA-----FEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAP 485

Query: 296 FISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQ 338
           F+   L +  +   L +F  +  +C      LP ETKG AL +
Sbjct: 486 FLLFRLAAVWLELPLIIFGILASICGGLVMLLP-ETKGIALPE 527


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 82/348 (23%), Positives = 148/348 (42%), Gaps = 53/348 (15%)

Query: 11  EFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFI 70
           E++PT+ R     L    +  G L++ G+A +I P   WR L    S P +I  +   ++
Sbjct: 214 EWMPTRGRTVAGILLGYSFTLGQLILAGVAYLIRP---WRCLQFAISAPFLIFFLYSWWL 270

Query: 71  PESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEK--RGRFADLLDAKYL-- 126
           PES+R+ +  G ++ A+  L++VA MN       +L + V+    +  FA +  +  +  
Sbjct: 271 PESSRWLLLHGKSQLAVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILD 330

Query: 127 --------RTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGES 178
                   + T  + VIW   S AYYG        L  DL    K   ++ +     G  
Sbjct: 331 LFRTPAIRKVTCCLMVIWFSNSVAYYG--------LAMDL---QKFGLSLYLVQALFGII 379

Query: 179 QSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNI 238
            +P      A   Y     +    + L  L ++   F+     +               +
Sbjct: 380 NTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVPEGTQI---------------L 424

Query: 239 CTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFIS 298
           CT+ A L       +  +A++F  VY++T E+YPT +R +GMG +    R+G + AP ++
Sbjct: 425 CTAQAAL------GKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLVT 478

Query: 299 QVLMSASIL-----GALCLFSSVCVVCAISAFTLP-IETKGRALQQIK 340
            +   ++IL     GA  + + + V        +P +ET     +++K
Sbjct: 479 TLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVK 526


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score = 75.1 bits (183), Expect = 8e-14
 Identities = 83/355 (23%), Positives = 153/355 (43%), Gaps = 59/355 (16%)

Query: 1   MAAGRLIIK----TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIR-V 55
           +A+G L++      EF+  K R +       F+  G+LL+  L   ++ T  W WL + +
Sbjct: 218 VASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLV-ALTGYLVRT--W-WLYQMI 273

Query: 56  ASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNR------SVMPEGKLVEP 109
            S   +  I+    +PE+  + +S G    A   ++ +AK NR      S +    L  P
Sbjct: 274 LSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGP 333

Query: 110 V------LEKRGRFADLLDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSK 163
           V      ++K        +    + TL +W+IW   S  +Y   L S  L          
Sbjct: 334 VSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNL---------- 383

Query: 164 SDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLS 223
                   GG+                +Y  + +  + EI       + ++ +GRR  L+
Sbjct: 384 --------GGN----------------EYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLA 419

Query: 224 ITMGCTALFFLLLNICTSSAGLIGFLFML--RALVAANFNTVYIYTAEVYPTTMRALGMG 281
            ++ C+AL   ++ +      ++G +  +  +  + A F  +Y+YTAE+YPT +R+L +G
Sbjct: 420 YSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVG 479

Query: 282 TSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRAL 336
           +   +CR+ +++APF S  L S  I        ++ ++  +    LP ET G+ L
Sbjct: 480 SGSMVCRLASILAPF-SVDLSSIWIFIPQLFVGTMALLSGVLTLKLP-ETLGKRL 532


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 71/347 (20%), Positives = 148/347 (42%), Gaps = 49/347 (14%)

Query: 7   IIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVA 66
           I+ TE L    R     L    + A   +++ L +  I    WR L+   ++PG++ +  
Sbjct: 216 ILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRD--WRMLLLALTVPGVLCVPL 273

Query: 67  FKFIPESARFNVSTGNTRAALATLERVAKMNRSVMP-----EGKLVEPVLEKRGRFADLL 121
           + FIPES R+ +S    R A   +++ AKMN   +P       + + P+ +++    DL 
Sbjct: 274 WWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLF 333

Query: 122 DAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQS 180
             + +   T+   ++W+  S  Y+ + L +  L                   GD+     
Sbjct: 334 RTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNL------------------HGDA----- 370

Query: 181 PCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITM--GCTALFFLLLNI 238
                      Y    +S + EI       L +  L RR  ++  +  G   L F+ L  
Sbjct: 371 -----------YLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVP 419

Query: 239 CTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFIS 298
                  IG + + +  + + F+ +Y++TAE+YPT +R + +G + +  R+G+++AP+  
Sbjct: 420 VDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFV 479

Query: 299 QV-----LMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQIK 340
            +     ++   ++G+L +   +  +    +  + +      +Q++K
Sbjct: 480 YLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVK 526


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 81/348 (23%), Positives = 143/348 (41%), Gaps = 66/348 (18%)

Query: 2   AAGRLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGI 61
           A   + + TE+L  ++R + + L   F+  G++L+ G+A  +     W+ L  V  I  I
Sbjct: 252 AISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIAYSL---PHWQLLFLVGGILVI 308

Query: 62  ILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVL-EKRGRFADL 120
             I     +PES R+ +  G  + A   L   A +N+  +P   L E  L  K+   A +
Sbjct: 309 PFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDELQLPRKKVTRASV 368

Query: 121 LD----AKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSG 176
           LD     +  + TL +  +W  +S+ Y+ + L   EL                       
Sbjct: 369 LDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMREL----------------------- 405

Query: 177 ESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLL 236
                        S +   ++ +I E+      I  +  +GR+ SL++T+    ++ LLL
Sbjct: 406 -----------GVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLL 454

Query: 237 NI----------------CTSSAGLIGFLFMLRAL-VAANFNTVYIYTAEVYPTTMRALG 279
                              T    +   + MLR   +AA     ++YTAE+ PT +RA G
Sbjct: 455 LFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATG 514

Query: 280 MGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTL 327
           +G        GA+++  ++ +  + S+L        +C V AI AF+L
Sbjct: 515 LGLVSLASVAGAILS--LTIISQTPSLLPIF-----LCCVLAIVAFSL 555


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 69/287 (24%), Positives = 115/287 (40%), Gaps = 51/287 (17%)

Query: 6   LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIV 65
           + +  E++P   R  +  L    +  G  L+ G+A  +     WR L  + S P     +
Sbjct: 207 MTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPH---WRHLQLLVSAPFFAFFI 263

Query: 66  AFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVL-----------EKR 114
              F  ESAR++ S+G     L  L+RVA++N       KL   VL           + +
Sbjct: 264 YSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQ 323

Query: 115 GRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGG 173
               +LL    LR   L + ++W   SFAYYG+++        DL               
Sbjct: 324 ASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM--------DL--------------- 360

Query: 174 DSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFF 233
                        F  S Y   +I    ++    +  L IN LGRR +    +    +  
Sbjct: 361 -----------QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 234 LLLNICTSSAGLI--GFLFMLRALVAANFNTVYIYTAEVYPTTMRAL 278
           LL  +      ++      + +  +AA+FN +++YT E+YPT +RA+
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRAV 456


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 69/287 (24%), Positives = 115/287 (40%), Gaps = 51/287 (17%)

Query: 6   LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIV 65
           + +  E++P   R  +  L    +  G  L+ G+A  +     WR L  + S P     +
Sbjct: 207 MTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPH---WRHLQLLVSAPFFAFFI 263

Query: 66  AFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVL-----------EKR 114
              F  ESAR++ S+G     L  L+RVA++N       KL   VL           + +
Sbjct: 264 YSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQ 323

Query: 115 GRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGG 173
               +LL    LR   L + ++W   SFAYYG+++        DL               
Sbjct: 324 ASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM--------DL--------------- 360

Query: 174 DSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFF 233
                        F  S Y   +I    ++    +  L IN LGRR +    +    +  
Sbjct: 361 -----------QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 234 LLLNICTSSAGLI--GFLFMLRALVAANFNTVYIYTAEVYPTTMRAL 278
           LL  +      ++      + +  +AA+FN +++YT E+YPT +RA+
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRAV 456


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 72/301 (23%), Positives = 119/301 (39%), Gaps = 66/301 (21%)

Query: 3   AGRLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGII 62
           AG  +I TEF+ +  R  +  + Q+ +  G + + GLA  +     WRWL    S+P  +
Sbjct: 219 AGYTLI-TEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPH---WRWLQLAVSLPTFL 274

Query: 63  LIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEG----KLVEPVLEKRG-RF 117
            ++ +  +PES R+ +S      A+  ++ +A+ N  + P       L E V EK    F
Sbjct: 275 FLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSF 334

Query: 118 ADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSG 176
           ADL     LR  T  +  +W   S  Y G+IL                            
Sbjct: 335 ADLFRTPRLRKRTFILMYLWFTDSVLYQGLIL---------------------------- 366

Query: 177 ESQSPCYCHMFAPSD--YRTMIISTIGEIALNPLNILGINFLGRRLSLSIT-----MGCT 229
                   HM A S   Y   + S + EI    + ++ I+ +GR   ++++       C 
Sbjct: 367 --------HMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACL 418

Query: 230 ALFFL-----LLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSG 284
            + F+      LNI     G +G    ++ +   N        AE+YPT +  +G    G
Sbjct: 419 VMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVN--------AELYPTFVSGVGPACRG 470

Query: 285 S 285
           S
Sbjct: 471 S 471


>gi|73695465 synaptic vesicle glycoprotein 2C [Homo sapiens]
          Length = 727

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 40/142 (28%), Positives = 70/142 (49%), Gaps = 3/142 (2%)

Query: 190 SDYRTMIISTIGEIALNPLNILG---INFLGRRLSLSITMGCTALFFLLLNICTSSAGLI 246
           S Y    ++ +G +A+ P NI+    ++ +GR   L  +M  + +    L   TS + +I
Sbjct: 578 SAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMI 637

Query: 247 GFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASI 306
           G L +   L  + +N++ + T E+YPT  RA G G   +LC+  A++   I   L+S + 
Sbjct: 638 GMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITK 697

Query: 307 LGALCLFSSVCVVCAISAFTLP 328
              + L S+V V   +    LP
Sbjct: 698 SIPILLASTVLVCGGLVGLCLP 719



 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 42/185 (22%), Positives = 70/185 (37%), Gaps = 51/185 (27%)

Query: 11  EFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGW-------------RWLIRVAS 57
           E L  + RG  L    +FW+ G +    +A  IIP  GW             R  + V +
Sbjct: 268 EVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCA 327

Query: 58  IPGIILIVAFKFIPESARFNVSTGNTRAALATL--------------ERVAKMNRSVMPE 103
           +P +  +VA  F+PES RF +  G    A   L              E+V  +N+   P 
Sbjct: 328 LPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTP- 386

Query: 104 GKLVEPVLEKRGRFADLLDAKYLR----------------------TTLQIWVIWLGISF 141
            K ++ ++E            ++R                       T+++ ++W  +SF
Sbjct: 387 -KQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSF 445

Query: 142 AYYGV 146
            YYG+
Sbjct: 446 GYYGL 450


>gi|216548223 synaptic vesicle glycoprotein 2 [Homo sapiens]
          Length = 742

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 39/151 (25%), Positives = 70/151 (46%), Gaps = 8/151 (5%)

Query: 192 YRTMIISTIGEIALNPLNILGINFLG-----RRLSLSITMGCTALFFLLLNICTSSAGLI 246
           Y    +S +G +A+ P NI+    +      R L+ S  M C + FFL      S + +I
Sbjct: 595 YMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFG--NSESAMI 652

Query: 247 GFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASI 306
             L +   +  A++N + + T E+YP+  R    G   +LC++ A++   I    +  + 
Sbjct: 653 ALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITK 712

Query: 307 LGALCLFSSVCVVCAISAFTLPIETKGRALQ 337
              +   S+   + +  A  LP ET+G+ LQ
Sbjct: 713 AAPILFASAALALGSSLALKLP-ETRGQVLQ 742



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 45/184 (24%), Positives = 69/184 (37%), Gaps = 47/184 (25%)

Query: 10  TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIG-------------WRWLIRVA 56
           +EFL  + RG  L    +FW+ G +    +A  IIP  G             WR  + V 
Sbjct: 281 SEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVC 340

Query: 57  SIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMN----------------RSV 100
           + P +  I A    PES RF +  G    A   L++V   N                +++
Sbjct: 341 AFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTI 400

Query: 101 MPEGKLVEPVLEKR------------------GRFADLLDAKYLRTTLQIWVIWLGISFA 142
             E +L+E   +                    G F      +Y R TL +  +W  +SF+
Sbjct: 401 HQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFS 460

Query: 143 YYGV 146
           YYG+
Sbjct: 461 YYGL 464


>gi|7662270 synaptic vesicle protein 2B homolog [Homo sapiens]
          Length = 683

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 41/165 (24%), Positives = 77/165 (46%), Gaps = 8/165 (4%)

Query: 177 ESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGR--RLSL---SITMGCTAL 231
           E +  C+  +   +D+   ++S +G +++ P NI+    + R  RL +   S+ +     
Sbjct: 521 EQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCC 580

Query: 232 FFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGA 291
           FFL      S + +IG+  +      A +N + + T E+YPT  RA   G    LC+ GA
Sbjct: 581 FFLFFG--NSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGA 638

Query: 292 MVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRAL 336
           ++   I    +  + +  + L ++  V   + A  LP ET+ + L
Sbjct: 639 ILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLP-ETREQVL 682



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 47/184 (25%), Positives = 73/184 (39%), Gaps = 47/184 (25%)

Query: 10  TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGW-------------RWLIRVA 56
           +EFL  + RG  L    +FW+ G L    +A  IIP  GW             R  + V 
Sbjct: 224 SEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVC 283

Query: 57  SIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNR------------SVMPEG 104
           ++P  + +VA KF+PES RF +  G    A   L++V   N             S +   
Sbjct: 284 ALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTP 343

Query: 105 KLVEPVLEKRG-----------RFADLLD-----------AKYLRTTLQIWVIWLGISFA 142
           K ++  +E +            RF  +               Y   TL + V+W  ++F+
Sbjct: 344 KQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFS 403

Query: 143 YYGV 146
           YYG+
Sbjct: 404 YYGL 407


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score = 55.1 bits (131), Expect = 9e-08
 Identities = 77/351 (21%), Positives = 136/351 (38%), Gaps = 65/351 (18%)

Query: 6   LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIV 65
           L +  E+  T  R   + +    + AG   + GLA  +     WR L   AS+P   + +
Sbjct: 215 LTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRD---WRTLQLAASVPFFAISL 271

Query: 66  AFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKY 125
              ++PESAR+ +  G    AL  L +VA++N     +   +E ++       ++  AK 
Sbjct: 272 ISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKE--EVASAKE 329

Query: 126 LRTTLQIW-------------VIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTG 172
            R+ L ++             V+   +  +YYG++    + L RD+        AV   G
Sbjct: 330 PRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVF-DLQSLGRDIFLLQALFGAVDFLG 388

Query: 173 GDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALF 232
                                                 L ++FLGRR   + +     L 
Sbjct: 389 ---------------------------------RATTALLLSFLGRRTIQAGSQAMAGLA 415

Query: 233 FLLLNICTSSAGLIGFLFML--RALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIG 290
            L   +       +  +F +  +     +   + IY AE++PT +R    G   ++ R+G
Sbjct: 416 ILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLG 475

Query: 291 AMVAPFI-----SQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRAL 336
           AM+ P I     +  L+   + G + + SS+ V+     F LP ET+G  L
Sbjct: 476 AMMGPLILMSRQALPLLPPLLYGVISIASSLVVL-----FFLP-ETQGLPL 520


>gi|47933389 solute carrier family 2, member 9 protein isoform 2
           [Homo sapiens]
          Length = 511

 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 76/349 (21%), Positives = 143/349 (40%), Gaps = 47/349 (13%)

Query: 10  TEFLPTKYRGYMLPLSQVFWLAGSLL--IIGLASVIIPTIGWRWLIRVASIPGIILIVAF 67
           +E  P + RG +  ++ +F   G     ++GL  ++     W +L  V  +P ++ +++ 
Sbjct: 161 SEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSL 220

Query: 68  KFIPESARFNV--STGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKY 125
            F+P+S R+ +       RA  A    + K + S   E  L E  +++  R   +L+   
Sbjct: 221 PFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLE--L 278

Query: 126 LRTTLQIW-VIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYC 184
           LR     W V+ + ++ A Y              +CG   ++    T    G++  P   
Sbjct: 279 LRAPYVRWQVVTVIVTMACY-------------QLCG--LNAIWFYTNSIFGKAGIP--- 320

Query: 185 HMFAPSDYRTMIISTIG-EIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTS-- 241
               P+    + +ST G E      + L I  LGRR  L    G   LFF  L I  +  
Sbjct: 321 ----PAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQ 376

Query: 242 -------SAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIG---- 290
                     ++G L ++ +  +      +I T E +  + R      +G++  +     
Sbjct: 377 DHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAV 436

Query: 291 AMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQI 339
            ++ PFI + L +   L    +F+++C+  AI  + +  ETK R   +I
Sbjct: 437 GLLFPFIQKSLDTYCFL----VFATICITGAIYLYFVLPETKNRTYAEI 481


>gi|47933387 solute carrier family 2, member 9 protein isoform 1
           [Homo sapiens]
          Length = 540

 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 76/349 (21%), Positives = 143/349 (40%), Gaps = 47/349 (13%)

Query: 10  TEFLPTKYRGYMLPLSQVFWLAGSLL--IIGLASVIIPTIGWRWLIRVASIPGIILIVAF 67
           +E  P + RG +  ++ +F   G     ++GL  ++     W +L  V  +P ++ +++ 
Sbjct: 190 SEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSL 249

Query: 68  KFIPESARFNV--STGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKY 125
            F+P+S R+ +       RA  A    + K + S   E  L E  +++  R   +L+   
Sbjct: 250 PFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLE--L 307

Query: 126 LRTTLQIW-VIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYC 184
           LR     W V+ + ++ A Y              +CG   ++    T    G++  P   
Sbjct: 308 LRAPYVRWQVVTVIVTMACY-------------QLCG--LNAIWFYTNSIFGKAGIP--- 349

Query: 185 HMFAPSDYRTMIISTIG-EIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTS-- 241
               P+    + +ST G E      + L I  LGRR  L    G   LFF  L I  +  
Sbjct: 350 ----PAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQ 405

Query: 242 -------SAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIG---- 290
                     ++G L ++ +  +      +I T E +  + R      +G++  +     
Sbjct: 406 DHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAV 465

Query: 291 AMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQI 339
            ++ PFI + L +   L    +F+++C+  AI  + +  ETK R   +I
Sbjct: 466 GLLFPFIQKSLDTYCFL----VFATICITGAIYLYFVLPETKNRTYAEI 510


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 77/334 (23%), Positives = 130/334 (38%), Gaps = 39/334 (11%)

Query: 10  TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKF 69
           TE++    +  ++ LS      G +++ GLA V      W+ L  VAS+P  +  +  ++
Sbjct: 222 TEWIRPNSKALVVILSSGALSIGQIILGGLAYVFRD---WQTLHVVASVPFFVFFLLSRW 278

Query: 70  IPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKYLRTT 129
           + ESAR+ + T      L  L +VA+ N     E  L   V+  R    + LDA   +TT
Sbjct: 279 LVESARWLIITNKLDEGLKALRKVARTNGIKNAEETLNIEVV--RSTMQEELDAAQTKTT 336

Query: 130 LQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAP 189
           +                          DL         + +       +  P Y  M   
Sbjct: 337 VC-------------------------DLFRNPSMRKRICILVFLRFANTIPFYGTMVNL 371

Query: 190 SDYRTMIIST---IGEIAL--NPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAG 244
               + I       G +AL    L +L +N +GRR+S  + M    L  L          
Sbjct: 372 QHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSILANTFVPKEMQ 431

Query: 245 LIGFLFMLRAL--VAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLM 302
            +        +   AA F++V ++  E+ PT +RA   G   +  RIGA +AP +  + +
Sbjct: 432 TLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGAALAPLLMTLTV 491

Query: 303 SASILGALCLFSSVCVVCAISAFTLPIETKGRAL 336
             + L  + ++    ++  +  F LP ETK   L
Sbjct: 492 FFTTLPWI-IYGIFPIIGGLIVFLLP-ETKNLPL 523


>gi|223029432 solute carrier family 2 (facilitated glucose
           transporter), member 6 isoform 1 [Homo sapiens]
          Length = 507

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 83/355 (23%), Positives = 139/355 (39%), Gaps = 41/355 (11%)

Query: 10  TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKF 69
           +E  P   RG +    Q+  + GSL +  L  +++P   WRWL      P +I+I+   F
Sbjct: 158 SEIAPPGVRGALGATPQLMAVFGSLSLYALG-LLLP---WRWLAVAGEAPVLIMILLLSF 213

Query: 70  IPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKYLRTT 129
           +P S RF +S G    AL  L  +   +  V  E + ++  + ++       +A+     
Sbjct: 214 MPNSPRFLLSRGRDEEALRALAWLRGTDVDVHWEFEQIQDNVRRQSSRVSWAEARAPHVC 273

Query: 130 LQIWVIWL--------GIS--FAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQ 179
             I V  L        GI+    Y   I  S  +L        K D+A+V  G     S 
Sbjct: 274 RPITVALLMRLLQQLTGITPILVYLQSIFDSTAVL-----LPPKDDAAIV--GAVRLLSV 326

Query: 180 SPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNIC 239
                 M        + +S     A N    L I+F  R LS + T G  +  +   ++ 
Sbjct: 327 LIAALTMDLAGRKVLLFVSAAIMFAANLTLGLYIHFGPRPLSPNSTAGLESESW--GDLA 384

Query: 240 TSSAGLIGFLFMLRALVAANFNTVY---------IYTAEVYPTTMRALGMGTSGSLCRIG 290
              A   G+L ++  L    F   Y         +  +EV P   R    G +  LC + 
Sbjct: 385 QPLAAPAGYLTLVPLLATMLFIMGYAVGWGPITWLLMSEVLPLRAR----GVASGLCVLA 440

Query: 291 AMVAPFI-----SQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQIK 340
           + +  F+       V+ +  +      F+++C+V  +       ETKGR+L+QI+
Sbjct: 441 SWLTAFVLTKSFLPVVSTFGLQVPFFFFAAICLVSLVFTGCCVPETKGRSLEQIE 495


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 65/303 (21%), Positives = 113/303 (37%), Gaps = 49/303 (16%)

Query: 40  ASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRS 99
           A+V      W  L  V S+P  +  +   ++ ESAR+ ++TG     L  L RVA +N  
Sbjct: 28  AAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGK 87

Query: 100 VMPEGKLVEPVLEKRGR-----------FADLLDAKYLRTTLQIWVI-WLGISFAYYGVI 147
              +  L   VL    R              LL    LR    I  + W    F ++G+ 
Sbjct: 88  GAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLA 147

Query: 148 LASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNP 207
           L    L                                    + +   +   + +I    
Sbjct: 148 LDLQAL----------------------------------GSNIFLLQMFIGVVDIPAKM 173

Query: 208 LNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRAL--VAANFNTVYI 265
             +L ++ LGRR +L+ ++    L  L   +     G +     +  L  V A F  + I
Sbjct: 174 GALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITI 233

Query: 266 YTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAF 325
           Y++E++PT +R   +G      R GA++ P +  + +    L  L ++ +V V+  ++A 
Sbjct: 234 YSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWL-PLLVYGTVPVLSGLAAL 292

Query: 326 TLP 328
            LP
Sbjct: 293 LLP 295


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.327    0.140    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,818,706
Number of Sequences: 37866
Number of extensions: 409339
Number of successful extensions: 1277
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 1157
Number of HSP's gapped (non-prelim): 102
length of query: 340
length of database: 18,247,518
effective HSP length: 103
effective length of query: 237
effective length of database: 14,347,320
effective search space: 3400314840
effective search space used: 3400314840
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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