Guide to the Human Genome
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Search of human proteins with 33457316

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|33457316 pleckstrin homology domain containing, family O
member 2 [Homo sapiens]
         (490 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33457316 pleckstrin homology domain containing, family O memb...   988   0.0  
gi|20149626 pleckstrin homology domain containing, family O memb...   131   1e-30
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    71   2e-12
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    63   7e-10
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    62   9e-10
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              59   1e-08
gi|41281612 zinc finger protein 828 [Homo sapiens]                     59   1e-08
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    58   2e-08
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     58   2e-08
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...    57   3e-08
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...    57   3e-08
gi|116284392 mucin 2 precursor [Homo sapiens]                          57   3e-08
gi|163965366 nascent polypeptide-associated complex alpha subuni...    57   4e-08
gi|33356148 formin-like 1 [Homo sapiens]                               57   4e-08
gi|62000702 diacylglycerol kinase kappa [Homo sapiens]                 56   6e-08
gi|110349719 titin isoform N2-A [Homo sapiens]                         55   1e-07
gi|19913398 smoothelin isoform a [Homo sapiens]                        55   1e-07
gi|19913396 smoothelin isoform b [Homo sapiens]                        55   2e-07
gi|19913394 smoothelin isoform c [Homo sapiens]                        55   2e-07
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    54   4e-07
gi|83921602 solute carrier family 38, member 10 isoform a [Homo ...    53   5e-07
gi|20070376 solute carrier family 38, member 10 isoform b [Homo ...    53   5e-07
gi|150170670 piccolo isoform 2 [Homo sapiens]                          53   7e-07
gi|150378539 piccolo isoform 1 [Homo sapiens]                          53   7e-07
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]          53   7e-07
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]          53   7e-07
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]          53   7e-07
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin...    52   9e-07
gi|237757310 synaptojanin 1 isoform a [Homo sapiens]                   52   1e-06
gi|50345997 E1A binding protein p300 [Homo sapiens]                    52   1e-06

>gi|33457316 pleckstrin homology domain containing, family O member
           2 [Homo sapiens]
          Length = 490

 Score =  988 bits (2553), Expect = 0.0
 Identities = 490/490 (100%), Positives = 490/490 (100%)

Query: 1   MEEEGVKEAGEKPRGAQMVDKAGWIKKSSGGLLGFWKDRYLLLCQAQLLVYENEDDQKCV 60
           MEEEGVKEAGEKPRGAQMVDKAGWIKKSSGGLLGFWKDRYLLLCQAQLLVYENEDDQKCV
Sbjct: 1   MEEEGVKEAGEKPRGAQMVDKAGWIKKSSGGLLGFWKDRYLLLCQAQLLVYENEDDQKCV 60

Query: 61  ETVELGSYEKCQDLRALLKRKHRFILLRSPGNKVSDIKFQAPTGEEKESWIKALNEGINR 120
           ETVELGSYEKCQDLRALLKRKHRFILLRSPGNKVSDIKFQAPTGEEKESWIKALNEGINR
Sbjct: 61  ETVELGSYEKCQDLRALLKRKHRFILLRSPGNKVSDIKFQAPTGEEKESWIKALNEGINR 120

Query: 121 GKNKAFDEVKVDKSCALEHVTRDRVRGGQRRRPPTRVHLKEVASAASDGLLRLDLDVPDS 180
           GKNKAFDEVKVDKSCALEHVTRDRVRGGQRRRPPTRVHLKEVASAASDGLLRLDLDVPDS
Sbjct: 121 GKNKAFDEVKVDKSCALEHVTRDRVRGGQRRRPPTRVHLKEVASAASDGLLRLDLDVPDS 180

Query: 181 GPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEV 240
           GPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEV
Sbjct: 181 GPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEV 240

Query: 241 SPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSE 300
           SPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSE
Sbjct: 241 SPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSE 300

Query: 301 AAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEG 360
           AAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEG
Sbjct: 301 AAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEG 360

Query: 361 TPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGPRHPLQPRERLYRAQLEVKVAS 420
           TPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGPRHPLQPRERLYRAQLEVKVAS
Sbjct: 361 TPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGPRHPLQPRERLYRAQLEVKVAS 420

Query: 421 EQTEKLLNKVLGSEPAPVSAETLLSQAVEQLRQATQVLQEMRDLGELSQEAPGLREKRKE 480
           EQTEKLLNKVLGSEPAPVSAETLLSQAVEQLRQATQVLQEMRDLGELSQEAPGLREKRKE
Sbjct: 421 EQTEKLLNKVLGSEPAPVSAETLLSQAVEQLRQATQVLQEMRDLGELSQEAPGLREKRKE 480

Query: 481 LVTLYRRSAP 490
           LVTLYRRSAP
Sbjct: 481 LVTLYRRSAP 490


>gi|20149626 pleckstrin homology domain containing, family O member
           1 [Homo sapiens]
          Length = 409

 Score =  131 bits (330), Expect = 1e-30
 Identities = 112/334 (33%), Positives = 153/334 (45%), Gaps = 37/334 (11%)

Query: 20  DKAGWIKKSSG-GLLG-FWKDRYLLLCQAQLLVYENE--DDQKCVETVELGSYEKCQDLR 75
           +K GW++K  G G+    WK+RY++L   QL + E E  D++   E  +L  YEKC++LR
Sbjct: 23  EKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELR 82

Query: 76  ---ALLKRKH-RFILLRS--PGNKVSDIKFQAPTGEEKESWIKALNEGINRGKNKAFDEV 129
              +  K+ H +F L  S  PGN   ++ F A + EEKESWI ALN  I R KN+  DEV
Sbjct: 83  KSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEV 142

Query: 130 KVDKSCALEHVTRDRVRGGQRRRPPTRVHLKEVAS-AASDGLLRLDL--------DVPDS 180
            V++   L H TRDR +    RRPPTR HL  VAS + SDG+L LDL        + P S
Sbjct: 143 TVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTS 202

Query: 181 GPPVFAPSNHVSEAQPRETPR--------PLMPPTKPFLAPETTSPGDRVETPVGERAPT 232
               F      S AQ   + R        P          P   +      TP   +  T
Sbjct: 203 CAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAPKKLT 262

Query: 233 PVSASSEVSPE---SQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAE 289
           P       S E   SQ D+ +       +E+PP   LP+  ++     S  +   A   E
Sbjct: 263 PTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQL-----SRIQDLVARKLE 317

Query: 290 PSQAPCSETSEA--APREGGKPPTPPPKILSEKL 321
            +Q   +E        R+   PP  PP   SE+L
Sbjct: 318 ETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQL 351



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 62/258 (24%), Positives = 88/258 (34%), Gaps = 49/258 (18%)

Query: 249 ETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGK 308
           E   EEDS    P      D+ K+      P        A  S +    T +    E   
Sbjct: 141 EVTVEEDSYLAHPTR----DRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPS 196

Query: 309 P--PTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPP 366
           P  PT   +     L  S+ ++  S   A           D     A  + +   P    
Sbjct: 197 PEEPTSCAESFRVDLDKSVAQLAGSRRRADS---------DRIQPSADRASSLSRPWEKT 247

Query: 367 KDATTSTALPPWDLPPQFHPRCSSLGDLLG--------------EGPRHPLQPRE-RLYR 411
               T T   P  L P    RC+SL ++L               E P  P  P   +L R
Sbjct: 248 DKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSR 307

Query: 412 AQLEVKVASEQTEKLLNKVLG-------------------SEPAPVSAETLLSQAVEQLR 452
            Q  V    E+T++LL +V G                   SE   +  E LL +A     
Sbjct: 308 IQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLGEASSNWS 367

Query: 453 QATQVLQEMRDLGELSQE 470
           QA +VLQE+R+L +L ++
Sbjct: 368 QAKRVLQEVRELRDLYRQ 385


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 87/310 (28%), Positives = 126/310 (40%), Gaps = 38/310 (12%)

Query: 178 PDSGPPVFAPSNHVSEAQPRETP------RPLMPPTK--PFLAPETTSPGDRVETPVGER 229
           P+S P  F+P      + P E+P       PL PP +  P   P   SP   +  P  E 
Sbjct: 507 PESSP--FSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESP---LSPPPEEL 561

Query: 230 APTPVSASSEVSPESQEDSETPAEEDSGSEQPPN-SVLPDKLKVSWENPSPQEAPAAESA 288
             +P   +S +SP  +E   +P  E+S    PP  S L    + S  +P P+E+P +   
Sbjct: 562 PTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPP 621

Query: 289 EPSQ-APCSETSEAAPREGGKPPTPPPKI-------LSEKLKASMGEMQASGPP--APGT 338
           E S+ +P  E S  +P     P +PPP++       +  +L     E   S PP  +P +
Sbjct: 622 EASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTS 681

Query: 339 VQVSVNGMDDSPE--PAKPSQAEGTPGTPPKDATTSTAL---PPWDLP--PQFHPRCSSL 391
                + +   PE  P  P   +     PP+D+  S  L   P   LP  PQ  PR  S 
Sbjct: 682 PPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPR--SE 739

Query: 392 GDLLGEGPRHP---LQPRERLYRAQLEVKVASEQTEKLLNKVLGSEP--APVSAETLLSQ 446
           G  L   P  P    +P E     Q E    S Q E+     +  EP  +P +    LS 
Sbjct: 740 GPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSP 799

Query: 447 AVEQLRQATQ 456
             E+L  + Q
Sbjct: 800 QPEELHLSPQ 809



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 56/206 (27%), Positives = 84/206 (40%), Gaps = 23/206 (11%)

Query: 182 PPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSP-GDRVETPVGERAPTPVSASSEV 240
           P + AP N      P     PL PP  P  +P +  P   R+  P  E   +P+  +  +
Sbjct: 428 PQLEAPLNEEMPLLPPPEESPLSPP--PEESPTSPPPEASRLSPPPEELPASPLPEALHL 485

Query: 241 SPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSE 300
           S   +E   +P  E+S    PP S     L+ S  +P P+E+P + + E   +P  E S 
Sbjct: 486 SRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSP-PEESPPSPALETPLSPPPEASP 544

Query: 301 AAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEG 360
            +P     P +PPP+           E+  S PP    +         SP P      E 
Sbjct: 545 LSPPFEESPLSPPPE-----------ELPTSPPPEASRLSPPPEESPMSPPP------EE 587

Query: 361 TPGTPPKDATTSTALPPWDLPPQFHP 386
           +P +PP +A  S   PP++  P   P
Sbjct: 588 SPMSPPPEA--SRLFPPFEESPLSPP 611



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 58/221 (26%), Positives = 82/221 (37%), Gaps = 45/221 (20%)

Query: 190 HVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSE 249
           HV+  QP+E P PL    KP L         ++E P+ E  P        + P  +E   
Sbjct: 400 HVTSMQPKE-PGPLQCEAKP-LGKAGVQLEPQLEAPLNEEMP--------LLPPPEESPL 449

Query: 250 TPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKP 309
           +P  E+S +  PP        + S  +P P+E PA        +P  E    +      P
Sbjct: 450 SPPPEESPTSPPP--------EASRLSPPPEELPA--------SPLPEALHLSRPLEESP 493

Query: 310 PTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDA 369
            +PPP+           E   S PP               PE + PS A  TP +PP +A
Sbjct: 494 LSPPPE-----------ESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEA 542

Query: 370 T--------TSTALPPWDLPPQFHPRCSSLGDLLGEGPRHP 402
           +        +  + PP +LP    P  S L     E P  P
Sbjct: 543 SPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSP 583



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 66/271 (24%), Positives = 93/271 (34%), Gaps = 41/271 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMP-PTKPFLAPETTSP--GDRVETPVGERAPTPVSASSE 239
            P  +P    S   P+     L P P +  L+PE   P    R E P  E    P      
Sbjct: 822  PCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELP 881

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            + P   E S +P   +    +P    L         +P P+E P + S EPS +P     
Sbjct: 882  LFPPPGEPSLSPLLGEPALSEPGEPPL---------SPLPEELPLSPSGEPSLSP----- 927

Query: 300  EAAPREGGKPPTPP------PKILSE--KLKASMGEMQASGPPAPGTVQVSVNGMD---- 347
            +  P +   PP  P      P  LS   +L+   G    S P +P    +    +     
Sbjct: 928  QLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPE 987

Query: 348  ---DSPEPAKPSQAEGTPGTP--PKDATTSTALPP-------WDLPPQFHPRCSSLGDLL 395
                 PEP  P     +PG+P  P        LPP         L PQ  P        L
Sbjct: 988  ANCTDPEPVPPMILPPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPAL 1047

Query: 396  GEGPRHPLQPRERLYRAQLEVKVASEQTEKL 426
                  PL P  ++     E ++   +TEK+
Sbjct: 1048 PLSVPSPLSPIGKVVGVSDEAELHEMETEKV 1078



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 63/249 (25%), Positives = 94/249 (37%), Gaps = 40/249 (16%)

Query: 176 DVPDSGPPVFAPSNHVSEAQPRETP---RPLMP-PTKPFLAPETTSP--GDRVETPVGER 229
           D P S PP  +P++   E      P    PL+P P +P L P +  P    R E P    
Sbjct: 695 DSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSP 754

Query: 230 AP-----TPVSASSEVSPESQEDSETPAEEDSG----SEQPPNSVLPDKLKVSWENPSPQ 280
            P     +P +    +SP+ +E       E+      +E P  S  P++L +S +   P 
Sbjct: 755 RPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPH 814

Query: 281 EAPAAESAEPSQAPCSETSEAAPR--EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGT 338
            +P  E  EP  +P  E S  +P+  E    P P    LS +L+      +   PP    
Sbjct: 815 LSPVPE--EPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPG 872

Query: 339 VQVSVNGMDDSPEPAKPS-------QAEGTPGTPP--------------KDATTSTALPP 377
              +   +   P P +PS        A   PG PP              + + +   +PP
Sbjct: 873 QCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPP 932

Query: 378 WDLPPQFHP 386
             LPP   P
Sbjct: 933 DPLPPPLSP 941



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 64/242 (26%), Positives = 93/242 (38%), Gaps = 21/242 (8%)

Query: 176 DVPDSGPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPT-PV 234
           D P S PP  +P +   E   R +P P++    P   P   SP     +P  E +PT P 
Sbjct: 632 DSPMSPPPEESPMSPPPEVS-RLSPLPVVSRLSP---PPEESP----LSPPPEESPTSPP 683

Query: 235 SASSEVSPESQEDSETPAEEDSGSEQPP-NSVLPDKLKVSWENPSPQEAPAAESAE-PSQ 292
             +S +SP  ++   +P  EDS +  PP +S++   L+ S   P P+E      +E P  
Sbjct: 684 PEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHL 743

Query: 293 APCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEP 352
           +P  E    +PR   + P   P+     L     E      P    +     G   SP+P
Sbjct: 744 SPRPEEPHLSPRP--EEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQP 801

Query: 353 AK----PSQAEGTPGTPPKDATTSTALPPWDLPPQFHPRCSS----LGDLLGEGPRHPLQ 404
            +    P   E      P++   S       L PQ    C S       L  E  + PL 
Sbjct: 802 EELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLS 861

Query: 405 PR 406
           PR
Sbjct: 862 PR 863



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 63/238 (26%), Positives = 88/238 (36%), Gaps = 45/238 (18%)

Query: 178  PDSGPPVFAPSNHVSE-AQPRETPRPLMPPTKPFLA-PETTSPGDRVETPVGERAPTPVS 235
            P S P +F P ++    AQP  TPRP  PP +   A P  + P D        R P    
Sbjct: 2362 PPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPF-----SRVP---- 2412

Query: 236  ASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPC 295
                 SP+SQ  S++P             + P  L      PSP   P  +S +P   P 
Sbjct: 2413 ----ASPQSQSSSQSP-------------LTPRPLSAEAFCPSP-VTPRFQSPDPYSRPP 2454

Query: 296  SETSEAAP-REGGKPPTP-PPKILSEKLKASMGEMQASGPPA--PGTVQVSVNGMDDSPE 351
            S      P     KPP P PP++  +    +   + A G PA  P      ++    S +
Sbjct: 2455 SRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQ 2514

Query: 352  PAKPSQAEGT---PGTP-------PKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGP 399
            P    ++ GT    GTP       P+     +  PP  +P    P    +    G GP
Sbjct: 2515 PPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPP--VPQPGLPPPHGINSHFGPGP 2570



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 55/230 (23%), Positives = 88/230 (38%), Gaps = 39/230 (16%)

Query: 178  PDSGP--PVFAPSNHVSEAQPRETPRPLMP-PTKPFLAPETTSPGDRVETPVGERAPTPV 234
            P  GP  P   PS+     +P + P P    PT+  L P  T PG    TP  +  PT  
Sbjct: 4300 PVLGPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQLPP--THPG----TPKPQ-GPTLE 4352

Query: 235  SASSEVSPESQEDSETPAEEDSGSEQPPN-----------SVLPDKLKVSWENPSPQEAP 283
                 VSP + + ++T   +  G   PP+           S++P  L        P+ + 
Sbjct: 4353 PPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSLVPGHLDQVNGQVVPEASQ 4412

Query: 284  AAESAEPSQAPCSETSEAAPREGGKPPTPPP----------------KILSEKLKASMGE 327
             +   EP + PC+  +++  RE    P   P                 +L +KL  +   
Sbjct: 4413 LSIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNV 4472

Query: 328  MQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPP 377
              ++G  + G ++  +NG  DS       + +GTP    +DA     L P
Sbjct: 4473 QLSTGRGSEG-LRAEINGHIDSKLAGLEQKLQGTPSN-KEDAAARKPLTP 4520



 Score = 37.0 bits (84), Expect = 0.041
 Identities = 60/256 (23%), Positives = 87/256 (33%), Gaps = 55/256 (21%)

Query: 174  DLDVPDSGPPVFAPSNHVSEAQPR---------------------ETPR---PLMPPTKP 209
            D D PDS  P  +P + + E  PR                       PR   P+ P TKP
Sbjct: 4698 DSDSPDSIVPASSPESILGEEAPRFPHLGSGRWEQEDRALSPVIPLIPRASIPVFPDTKP 4757

Query: 210  FLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDK 269
            + A     PG    T   +   + VS    VS  +       A+  +G       +L  K
Sbjct: 4758 YGALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAAA-------AKNLNGVMVAVAELLSMK 4810

Query: 270  LKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPPPKILSE--------KL 321
            +  S+E   P E+PA    EP +              GK P   P  L +         L
Sbjct: 4811 IPNSYEVLFP-ESPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTL 4869

Query: 322  KASMG-------EMQASGPPAPGTVQVSVNGMD----DSPEPAKPSQAEG----TPGTPP 366
            K+ +        E  A  PP   +   +V+ +D     +P P +PS        +P +PP
Sbjct: 4870 KSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPP 4929

Query: 367  KDATTSTALPPWDLPP 382
             +        P   PP
Sbjct: 4930 TEPLVELPTEPLAEPP 4945



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 46/179 (25%), Positives = 66/179 (36%), Gaps = 28/179 (15%)

Query: 220  DRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDK--------LK 271
            +R E P  ++       + E S   +  ++TP  ED G +  P    P+K        L 
Sbjct: 1813 ERKELPTSQKGDDGPDIADEESRGLEGKADTPGPEDGGVKASPVPSDPEKPGTPGEGMLS 1872

Query: 272  VSWENPSPQEAPAAESAEPSQ----APCSETSE-----AAPREGGKPPTPPPKILSEKLK 322
               +  S +E P  ES +  Q       SE  +         EG + P   P +      
Sbjct: 1873 SDLDRISTEELPKMESKDLQQLFKDVLGSEREQHLGCGTPGLEGSRTPLQRPFLQG---G 1929

Query: 323  ASMGEMQASGP--PAPGTVQVSV-----NGMDDSPEPAKP-SQAEGTPGTPPKDATTST 373
              +G + +S P    PG  Q         G   SPEP +P S   G+ GT P   TT T
Sbjct: 1930 LPLGNLPSSSPMDSYPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPT 1988



 Score = 32.3 bits (72), Expect = 1.0
 Identities = 34/142 (23%), Positives = 51/142 (35%), Gaps = 20/142 (14%)

Query: 284  AAESAEPSQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAP-GTVQVS 342
            A  +  PS +P   +S +     G  P  PP +L               PPAP G++   
Sbjct: 2583 ATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLP--------------PPAPDGSLPYL 2628

Query: 343  VNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGPRHP 402
             +G         P +    PGT        ++L   +LP    P  S L     E  R  
Sbjct: 2629 SHGASQRSGITSPVEKREDPGT-----GMGSSLATAELPGTQDPGMSGLSQTELEKQRQR 2683

Query: 403  LQPRERLYRAQLEVKVASEQTE 424
             + RE L R Q++     ++ E
Sbjct: 2684 QRLRELLIRQQIQRNTLRQEKE 2705



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 22/81 (27%), Positives = 32/81 (39%), Gaps = 9/81 (11%)

Query: 287  SAEPSQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGM 346
            SA P + P    S  AP     P +PP + L E     + E     PP P  + ++ +  
Sbjct: 4907 SAPPPEEPSPPPSPLAP----SPASPPTEPLVELPTEPLAE-----PPVPSPLPLASSPE 4957

Query: 347  DDSPEPAKPSQAEGTPGTPPK 367
               P+P      EG    PP+
Sbjct: 4958 SARPKPRARPPEEGEDSRPPR 4978



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 38/149 (25%), Positives = 52/149 (34%), Gaps = 24/149 (16%)

Query: 182  PPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVS 241
            PP  +P    S       P    PP  P   P   SP  +V   V + A        E+ 
Sbjct: 1021 PPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPIGKV-VGVSDEAEL-----HEME 1074

Query: 242  PESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEA 301
             E   + E PA E S +   P+ +           P+P  APA +             + 
Sbjct: 1075 TEKVSEPECPALEPSATSPLPSPM------GDLSCPAPSPAPALDDFS------GLGEDT 1122

Query: 302  APREG----GKPPTP--PPKILSEKLKAS 324
            AP +G    G  P P   P  L+ +LK S
Sbjct: 1123 APLDGIDAPGSQPEPGQTPGSLASELKGS 1151



 Score = 30.0 bits (66), Expect = 5.0
 Identities = 45/226 (19%), Positives = 85/226 (37%), Gaps = 30/226 (13%)

Query: 255  DSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTP-- 312
            +S +E+     L   ++     P  +  PAA+++EP  A      +    EGG+ P+P  
Sbjct: 3074 ESANEKAEREALLRGVEPGPLGPEERPPPAADASEPRLASVLPEVKPKVEEGGRHPSPCQ 3133

Query: 313  ----PPKILSEKLKASMGEMQASGPPAPGT--VQVSVNGMDDSPEPAKPSQAEGTPGTPP 366
                 PK+       S+G     G    G+   ++       S   A+ +    T G P 
Sbjct: 3134 FTIATPKVEPAPAANSLGLGLKPGQSMMGSRDTRMGTGPFSSSGHTAEKASFGATGGPPA 3193

Query: 367  KDATTSTALPPW--DLPPQFHPRCSSLGDLLGEGPRHPLQPRERLYRAQLEVKVASEQTE 424
               T S    P    L  +F     +L   L  GP                   + ++ +
Sbjct: 3194 HLLTPSPLSGPGGSSLLEKFELESGAL--TLPGGP-----------------AASGDELD 3234

Query: 425  KLLNKVLGSEPAPVSAETLLSQAVEQLRQATQVLQEMRDLGELSQE 470
            K+ + ++ SE  P+  E LL    ++L++  Q+  +++   +  Q+
Sbjct: 3235 KMESSLVASE-LPLLIEDLLEHEKKELQKKQQLSAQLQPAQQQQQQ 3279


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 78/272 (28%), Positives = 103/272 (37%), Gaps = 51/272 (18%)

Query: 134 SCALEHVTRDRVRGGQRRRPPTRVHLKEVASAASDGLLRLDLDVPDSGPPVF----APSN 189
           S A EH T +      RRRP     L+  AS +             SGP       AP+ 
Sbjct: 201 SSASEHSTTEPSPAA-RRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPA- 258

Query: 190 HVSEAQPRET----PRPLMPPTK---PFLAPETTSPGDRVETPVGERAPTPV---SASSE 239
           H S+ +P+      P  + PP K   P L P ++SP   + TP     P+P    S  + 
Sbjct: 259 HPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSP---LATPSPSAPPSPSAPPSLQTL 315

Query: 240 VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            SP +   S+      S + Q  +S LP         P PQ AP A +  P QAP S   
Sbjct: 316 PSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQ-APPALALPPLQAPPS--- 371

Query: 300 EAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAE 359
                    PP  PP          +  +    P AP  + V +     SP P+ P QA 
Sbjct: 372 ---------PPASPP----------LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAP 412

Query: 360 GTP---------GTPPKDATTSTALPPWDLPP 382
            +P          TPP  A  S A PP  +PP
Sbjct: 413 FSPPASPPVSPSATPPSQAPPSLAAPPLQVPP 444



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 53/225 (23%), Positives = 78/225 (34%), Gaps = 30/225 (13%)

Query: 182 PPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGER---APTPVSASS 238
           PP   P   VS A    T  P         A    S G  ++ P       + TP+S+ +
Sbjct: 191 PPTEGPRKSVSSASEHSTTEPSPA------ARRRPSAGGGLQRPASRSLSSSATPLSSPA 244

Query: 239 EVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSET 298
              P ++     PA       +   ++ P           PQ  P  + A P+  P S +
Sbjct: 245 RSGPSARGTPRAPAHPSQPKPKGLQALRP-----------PQVTPPRKDAAPALGPLSSS 293

Query: 299 SEAAPREGGKP-PTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQ 357
             A P     P P+ PP + +     +    QA+      T+Q + + +        PS 
Sbjct: 294 PLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFL--------PSP 345

Query: 358 AEGTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGPRHP 402
                 TPP  A  + ALPP   PP   P    L  L    P+ P
Sbjct: 346 PLSPLATPPPQAPPALALPPLQAPPS-PPASPPLSPLATPSPQAP 389



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 51/208 (24%), Positives = 76/208 (36%), Gaps = 34/208 (16%)

Query: 178 PDSGPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSAS 237
           P + PP+ AP   +++  P+  P    PP +   +P  + PG         +AP   SAS
Sbjct: 460 PQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG---------QAPFSPSAS 510

Query: 238 SEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSE 297
             +SP +    + P    +   Q P              PSP  +P  ++      P  +
Sbjct: 511 LPMSPLATPPPQAPPVLAAPLLQVP--------------PSPPASPTLQAPRRPPTPGPD 556

Query: 298 TSEAAPR--EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKP 355
           TS + PR      P  PPP   S     S  ++      A  T +  + G D  PE    
Sbjct: 557 TSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPE-ELRGYDSGPE---- 611

Query: 356 SQAEGTPGTPPKDATTSTALP-PWDLPP 382
               G   +PP DA  +   P  W   P
Sbjct: 612 ---GGAAASPPPDAELAACHPAAWSRGP 636



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 53/227 (23%), Positives = 79/227 (34%), Gaps = 18/227 (7%)

Query: 178 PDSGPPVFAPSNHVSEAQPRETPRPLM--------PPTKPFLAPETTSPGDRVETPVGER 229
           P + PPV   +   S+A P     PL         PP  P   P   +P      P+   
Sbjct: 415 PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLA 474

Query: 230 APTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAE 289
            P P +  +  +P  Q     PA     +   P++ LP    +S     P +AP   +A 
Sbjct: 475 KPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLP----MSPLATPPPQAPPVLAAP 530

Query: 290 PSQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMD-- 347
             Q P S  +    +   +PPTP P       + ++       PP   +   +++G D  
Sbjct: 531 LLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLA 590

Query: 348 --DSPEPAKPSQAEGTPGTPPKDATTSTALPPWDLPPQFHPRCSSLG 392
              S   + P +  G    P   A  S   PP       HP   S G
Sbjct: 591 GHSSSATSTPEELRGYDSGPEGGAAASP--PPDAELAACHPAAWSRG 635



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 54/222 (24%), Positives = 75/222 (33%), Gaps = 39/222 (17%)

Query: 202 PLMPPTKPFLAPETTSPGDRVETPVGERAPT------PVSASSEVSPESQEDSETPAEED 255
           P  PP +   +P  + P     TP  +  P+       V  S   SP     +  P +  
Sbjct: 404 PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP 463

Query: 256 SGSEQPPNSVL--PDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPP 313
                PP  +   P +   +   P  Q  P+  ++ P QAP S ++         PP   
Sbjct: 464 PPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQA 523

Query: 314 PKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS-QAEGTPGTPPKDATTS 372
           P +L+  L           PP+P               PA P+ QA   P TP  D + S
Sbjct: 524 PPVLAAPL--------LQVPPSP---------------PASPTLQAPRRPPTPGPDTSVS 560

Query: 373 -----TALPPWDLPPQFHPRCSSLG--DLLGEGPRHPLQPRE 407
                 AL P   PP      S+L   DL G        P E
Sbjct: 561 GPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEE 602



 Score = 32.7 bits (73), Expect = 0.77
 Identities = 42/166 (25%), Positives = 57/166 (34%), Gaps = 41/166 (24%)

Query: 257 GSEQPPNSVLPDKLKVSWENPS------------------PQEAPAAESAEPSQAPCSET 298
           GS +PP  V P  L+V     +                  P+ AP A     S+ P S  
Sbjct: 31  GSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPPASGR 90

Query: 299 SEAAPREGGKPPTP------------PPKILSEKLKASMGEMQASG--PPAPGTVQVSVN 344
            E AP      P P            P  +  + L+ S  E  A G    AP    +S  
Sbjct: 91  GERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAG 150

Query: 345 GMDD---------SPEPAKPSQAEGTPGTPPKDATTSTALPPWDLP 381
              D         SP  A+ S+A GT    P+ A ++   PP + P
Sbjct: 151 ARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGP 196


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 69/256 (26%), Positives = 97/256 (37%), Gaps = 52/256 (20%)

Query: 139 HVTRDRVRGGQRRRPPTRVHLKEVASAASDGLLRLDLDVPDSGPPVFAPSNHVSEAQPRE 198
           H ++ + +G Q  RPP     ++ A+ A           P S  P+  PS       P  
Sbjct: 268 HPSQPKPKGLQALRPPQVTPPRKDAAPALG---------PLSSSPLATPS-------PSA 311

Query: 199 TPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPV---SASSEVSPESQEDSETPAEED 255
             +   PPT P   P ++S   ++ TP+    P+P    S  +  SP +   S+      
Sbjct: 312 ALQSQAPPTLP-ATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLG 370

Query: 256 SGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPPPK 315
           S + Q  +S LP         P PQ AP A +  P QAP S            PP  PP 
Sbjct: 371 SPTLQATHSFLPSPPLSPLATPPPQ-APPALALPPLQAPPS------------PPASPP- 416

Query: 316 ILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTP---------GTPP 366
                    +  +    P AP  + V +     SP P+ P QA  +P          TPP
Sbjct: 417 ---------LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPP 467

Query: 367 KDATTSTALPPWDLPP 382
             A  S A PP  +PP
Sbjct: 468 SQAPPSLAAPPLQVPP 483



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 61/249 (24%), Positives = 84/249 (33%), Gaps = 48/249 (19%)

Query: 182 PPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGER---APTPVSASS 238
           PP   P   VS A    T  P         A    S G  ++ P       + TP+S+ +
Sbjct: 200 PPTEGPRKSVSSASEHSTTEPSPA------ARRRPSAGGGLQRPASRSLSSSATPLSSPA 253

Query: 239 EVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSET 298
              P ++     PA       +   ++ P           PQ  P  + A P+  P S +
Sbjct: 254 RSGPSARGTPRAPAHPSQPKPKGLQALRP-----------PQVTPPRKDAAPALGPLSSS 302

Query: 299 SEAAPR-----EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPA 353
             A P      +   PPT P    S  L   +       PP+P +   S+  +  SP   
Sbjct: 303 PLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSP-SAPPSLQTLP-SPPAT 360

Query: 354 KPSQAE---GTP-----------------GTPPKDATTSTALPPWDLPPQFHPRCSSLGD 393
            PSQA    G+P                  TPP  A  + ALPP   PP   P    L  
Sbjct: 361 PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPS-PPASPPLSP 419

Query: 394 LLGEGPRHP 402
           L    P+ P
Sbjct: 420 LATPSPQAP 428



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 51/208 (24%), Positives = 76/208 (36%), Gaps = 34/208 (16%)

Query: 178 PDSGPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSAS 237
           P + PP+ AP   +++  P+  P    PP +   +P  + PG         +AP   SAS
Sbjct: 499 PQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPG---------QAPFSPSAS 549

Query: 238 SEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSE 297
             +SP +    + P    +   Q P              PSP  +P  ++      P  +
Sbjct: 550 LPMSPLATPPPQAPPVLAAPLLQVP--------------PSPPASPTLQAPRRPPTPGPD 595

Query: 298 TSEAAPR--EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKP 355
           TS + PR      P  PPP   S     S  ++      A  T +  + G D  PE    
Sbjct: 596 TSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPE-ELRGYDSGPE---- 650

Query: 356 SQAEGTPGTPPKDATTSTALP-PWDLPP 382
               G   +PP DA  +   P  W   P
Sbjct: 651 ---GGAAASPPPDAELAACHPAAWSRGP 675



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 53/227 (23%), Positives = 79/227 (34%), Gaps = 18/227 (7%)

Query: 178 PDSGPPVFAPSNHVSEAQPRETPRPLM--------PPTKPFLAPETTSPGDRVETPVGER 229
           P + PPV   +   S+A P     PL         PP  P   P   +P      P+   
Sbjct: 454 PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLA 513

Query: 230 APTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAE 289
            P P +  +  +P  Q     PA     +   P++ LP    +S     P +AP   +A 
Sbjct: 514 KPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLP----MSPLATPPPQAPPVLAAP 569

Query: 290 PSQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMD-- 347
             Q P S  +    +   +PPTP P       + ++       PP   +   +++G D  
Sbjct: 570 LLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLA 629

Query: 348 --DSPEPAKPSQAEGTPGTPPKDATTSTALPPWDLPPQFHPRCSSLG 392
              S   + P +  G    P   A  S   PP       HP   S G
Sbjct: 630 GHSSSATSTPEELRGYDSGPEGGAAASP--PPDAELAACHPAAWSRG 674



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 54/222 (24%), Positives = 75/222 (33%), Gaps = 39/222 (17%)

Query: 202 PLMPPTKPFLAPETTSPGDRVETPVGERAPT------PVSASSEVSPESQEDSETPAEED 255
           P  PP +   +P  + P     TP  +  P+       V  S   SP     +  P +  
Sbjct: 443 PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP 502

Query: 256 SGSEQPPNSVL--PDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPP 313
                PP  +   P +   +   P  Q  P+  ++ P QAP S ++         PP   
Sbjct: 503 PPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQA 562

Query: 314 PKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS-QAEGTPGTPPKDATTS 372
           P +L+  L           PP+P               PA P+ QA   P TP  D + S
Sbjct: 563 PPVLAAPL--------LQVPPSP---------------PASPTLQAPRRPPTPGPDTSVS 599

Query: 373 -----TALPPWDLPPQFHPRCSSLG--DLLGEGPRHPLQPRE 407
                 AL P   PP      S+L   DL G        P E
Sbjct: 600 GPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEE 641


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 67/249 (26%), Positives = 96/249 (38%), Gaps = 35/249 (14%)

Query: 149 QRRRPPTRVHLKEVASAASDGLLRLDLDVPD------SGPPVFAPSNHVSEAQPR-ETPR 201
           Q  +P     L+   ++ S  L  L     D      SGP +  P        P  + P 
Sbjct: 609 QPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPA 668

Query: 202 PLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEED---SGS 258
           P  PP     +P   +P   +  P     P   + +S  SP + + + TP +E    S  
Sbjct: 669 PFSPPPSKPRSPNPAAPA--LAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKD 726

Query: 259 EQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPPPKILS 318
           + PP S  P         P P + P      PS    SET+E   ++   PP PPP    
Sbjct: 727 QSPPPSPPPSY----HPPPPPTKKPEVVVEAPS---ASETAEEPLQDPNWPPPPPPA--P 777

Query: 319 EKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTAL--- 375
           E+   SM +     PP      V+      SPEPA PS +     +P   ++++TAL   
Sbjct: 778 EEQDLSMADFP---PPEEAFFSVA------SPEPAGPSGSPELVSSPAASSSSATALQIQ 828

Query: 376 PPW--DLPP 382
           PP   D PP
Sbjct: 829 PPGSPDPPP 837



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 55/252 (21%), Positives = 82/252 (32%), Gaps = 57/252 (22%)

Query: 180  SGPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSE 239
            S P   + S    + QP  +P P  PP  P  AP +++PG   + P  E    PV  S  
Sbjct: 813  SSPAASSSSATALQIQPPGSPDP--PPAPPAPAPASSAPGHVAKLPQKE----PVGCSKG 866

Query: 240  VSPESQE-----------------------DSETPAEEDSGSEQPPNSVLPDKLKVSWEN 276
              P  ++                        + TPA   S  ++P    L  +       
Sbjct: 867  GGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGR------- 919

Query: 277  PSPQEAPA----------AESAEPSQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMG 326
             SP  AP+          A S   S+   S      P    +PP  P    S        
Sbjct: 920  ASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSR 979

Query: 327  EMQASGPPAPGT-------VQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPPWD 379
            ++Q   P +P T       +   +  + +   P  P ++   P  PP     S  +PP  
Sbjct: 980  KLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAP--PPVARKPSVGVPPPA 1037

Query: 380  LPPQFHPRCSSL 391
             P   +PR   L
Sbjct: 1038 SPS--YPRAEPL 1047


>gi|41281612 zinc finger protein 828 [Homo sapiens]
          Length = 812

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 66/264 (25%), Positives = 98/264 (37%), Gaps = 40/264 (15%)

Query: 151 RRPPTRVHLKEVASAASDGLLRLDLDVPDSGPPVFAPSNHVSEAQPRETPRPL-MPPTKP 209
           + PP   H K   ++A           P S P +   +  +      E+P+P  + P +P
Sbjct: 107 KSPPLPEHQKIPCNSAE----------PKSIPALSMETQKLGSVLSPESPKPTPLTPLEP 156

Query: 210 FLAPETTSPGDRVETPVGERAPT-PVSASSEVSPESQE--DSETPAEEDSGSEQPPNSVL 266
                  SP   ++TP+    P+ P S SS   P+S    +S+  A   S   Q P  V 
Sbjct: 157 QKPGSVVSP--ELQTPLPSPEPSKPASVSSPEPPKSVPVCESQKLAPVPSPEPQKPAPVS 214

Query: 267 PDKLKVSWENPSPQEA---PAAESAEPSQAPCSETSEAAPREGGKPPTPPPKILSEKLKA 323
           P+ +K +  NP PQ+    P       + +P S    A+P   G  P   P    E  K+
Sbjct: 215 PESVKATLSNPKPQKQSHFPETLGPPSASSPESPVLAASPEPWGPSPAASP----ESRKS 270

Query: 324 SMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPP--WDLP 381
           +         P+P           +SPEP KP      P   P+    + A+ P  W   
Sbjct: 271 ARTTSPEPRKPSP----------SESPEPWKP-----FPAVSPEPRRPAPAVSPGSWKPG 315

Query: 382 PQFHPRCSSLGDLLGEGPRHPLQP 405
           P   PR          GP  P +P
Sbjct: 316 PPGSPRPWKSNPSASSGPWKPAKP 339


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 65/234 (27%), Positives = 87/234 (37%), Gaps = 33/234 (14%)

Query: 178 PDSGPPVFAPSNHVSEAQPRETPRPL----MPP--TKPFLAPETT-SPGDRVETPVGER- 229
           P S P    P   +S         PL    MPP  T+  LAP +  +P   + TP  E  
Sbjct: 479 PLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENL 538

Query: 230 ---APTPV-SASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAA 285
              AP P+ +AS+ ++    E    PA     +   P +  P +   S   P PQ  PA 
Sbjct: 539 PSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPAL 598

Query: 286 ESAEPSQAPCSETSEAAPREGGKPPTPPPKILSEKLKAS--------MGEMQASGPPAPG 337
            S      P    S  A      PP  PP +    L+A         +  +    P AP 
Sbjct: 599 ASPPLQGLPSPPLSPLAT----PPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPN 654

Query: 338 TVQVSVNGMDDSPEPAKPSQAEGTP---------GTPPKDATTSTALPPWDLPP 382
            + V +     SP P+ P QA  +P          TPP  A  S A PP  +PP
Sbjct: 655 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP 708



 Score = 55.8 bits (133), Expect = 8e-08
 Identities = 75/309 (24%), Positives = 116/309 (37%), Gaps = 56/309 (18%)

Query: 150 RRRPPTRVHLKEVASA-----------------ASDGLLR-LDLDVPDSGPPVFAPSNHV 191
           R RPPT    K V+SA                 A  GL R     +  S  P+ +P+   
Sbjct: 197 RPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG 256

Query: 192 SEAQ--PRETPRPLMPPTKPFLA---PETTSPGDRVETPVGERAPTPVSASSEVSPESQ- 245
             A+  PR    P  P  K   A   P+ T P       +G  + +P++  S    +++ 
Sbjct: 257 PSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARP 316

Query: 246 ----EDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS-- 299
               +++ TP         P  + LP         PS Q  P+  +  PSQAP S T+  
Sbjct: 317 VPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPP 376

Query: 300 -EAAPREGGKPPTP-PPKILSEKLKA-----SMGEMQASGPPAPGTVQVSVNGMDDSP-- 350
            +A P     PP   P  + S  L+A     ++  +QA+      T+Q + + +  SP  
Sbjct: 377 MQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQ 436

Query: 351 ------EPAKPSQAE----------GTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDL 394
                  P++P+               P +PP   + S A+ P   P   HP   +L  L
Sbjct: 437 TQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHP-LQALSSL 495

Query: 395 LGEGPRHPL 403
               P+ PL
Sbjct: 496 ASHSPQAPL 504



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 65/244 (26%), Positives = 83/244 (34%), Gaps = 26/244 (10%)

Query: 178 PDSGPPVFAPSNHVSEAQPRETPRPLM----PPTKPFLAPETTSPGDRVETPVGERAPTP 233
           P + PPV   +   S+A P     PL     PP  P ++P  T P      P     P  
Sbjct: 679 PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQA--PPPLAAPPLQ 736

Query: 234 VSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPD---KLKVSWENPSPQEAPAAESAEP 290
           V  S   SP     +  P         PP  V P     L +S     P +AP A +  P
Sbjct: 737 VPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPP 796

Query: 291 SQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSP 350
            QA  S  +       G+ P  P   L       M  +    P AP  +   +  +  SP
Sbjct: 797 LQALPSPPASFP----GQAPFSPSASLP------MSPLATPPPQAPPVLAAPLLQVPPSP 846

Query: 351 EPAKPSQAEGTPGTPPKDATTS-----TALPPWDLPPQFHPRCSSLG--DLLGEGPRHPL 403
             +   QA   P TP  D + S      AL P   PP      S+L   DL G       
Sbjct: 847 PASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATS 906

Query: 404 QPRE 407
            P E
Sbjct: 907 TPEE 910



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 64/240 (26%), Positives = 89/240 (37%), Gaps = 23/240 (9%)

Query: 181 GPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPV--SASS 238
           G P    ++      PR+T   L  P++P   P  + P   ++ P+   A  P+  S S 
Sbjct: 419 GSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPP---LQAPLSLPASPPLQTSLSP 475

Query: 239 EVSPESQEDSETPAEEDSG----SEQPPNSVL---PDKLKVSWENPSPQEAPAAESAEP- 290
            VSP S   +  P +  S     S Q P S L   P + + S   PS Q  PA+ +  P 
Sbjct: 476 AVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPL 535

Query: 291 ----SQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQV----S 342
               S AP    + +AP       TPP       L+A    +    P  P ++      +
Sbjct: 536 ENLPSLAPPPLQTASAPLTTPHLETPPCPAPCP-LQAPPSPLTTPPPETPSSIATPPPQA 594

Query: 343 VNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGPRHP 402
              +   P    PS       TPP  A    ALPP   PP   P    L  L    P+ P
Sbjct: 595 PPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPS-PPASPPLSPLATPSPQAP 653



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 52/217 (23%), Positives = 74/217 (34%), Gaps = 51/217 (23%)

Query: 175 LDVPDSGPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPV 234
           L VP S PP   P + +++  P+  P    PP +   +P  + PG         +AP   
Sbjct: 766 LQVPPS-PPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPG---------QAPFSP 815

Query: 235 SASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAP 294
           SAS  +SP +    + P    +   Q P              PSP  +P  ++      P
Sbjct: 816 SASLPMSPLATPPPQAPPVLAAPLLQVP--------------PSPPASPTLQAPRRPPTP 861

Query: 295 CSETSEAAPRE--GGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPE- 351
             +TS + PR      P  PPP   S     S  ++      A  T +  + G D  PE 
Sbjct: 862 GPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPE-ELRGYDSGPEG 920

Query: 352 -----------------------PAKPSQAEGTPGTP 365
                                  PA P    G PG P
Sbjct: 921 GAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAP 957


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 88/407 (21%), Positives = 160/407 (39%), Gaps = 36/407 (8%)

Query: 88  RSPGNKVSDIKFQAPTGEEKESWIKALNEGINRGKNKAFDEVKVDKSCALEHVTRDRVRG 147
           +SP    S  K ++P  EE +S  +A +      K+ A  EVK  +    +  T++  + 
Sbjct: 593 KSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA--EVKSPEKA--KSPTKEEAKS 648

Query: 148 GQRRRPPTRVHLKEVASAASDGLLRLDLDVPDSGPPVFAPSNHVSEAQPRETPRPLMPPT 207
            ++ + P +   K    A S   ++ +   P+      A S   +EA+   +P     P 
Sbjct: 649 PEKAKSPEKEEAKSPEKAKSP--VKAEAKSPEK-----AKSPVKAEAK---SPEKAKSPV 698

Query: 208 KPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQ--EDSETPAEEDSGSEQPPNSV 265
           K     E  SP ++ ++PV E A +P  A S V  E++  E +++P +E++ S  P  + 
Sbjct: 699 KE----EAKSP-EKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKS--PEKAK 751

Query: 266 LPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPPPKILSEKLKASM 325
            P+K K         + PA E A        E +++  +E  K P      L E  KA  
Sbjct: 752 SPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPE 811

Query: 326 GEM---QASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPPWDLP- 381
            E+   +    P     +     + + P+ A+  +A  TP T  K  +     P  + P 
Sbjct: 812 KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPK 871

Query: 382 ----PQFHPRCSSLGDLLGEGPRHPLQPRERL----YRAQLEVKVASEQTEKLLNKVLGS 433
                +  P      +   E  +   + ++++      A  +V+V  +   K   +V   
Sbjct: 872 PKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK 931

Query: 434 EPAPVSAETLLSQAVEQLRQATQVLQEMRDLGELSQEAPGLREKRKE 480
           EP    A+   S+  E+   A +      +  +  +E P    K KE
Sbjct: 932 EPDDAKAKE-PSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKE 977



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 50/166 (30%), Positives = 77/166 (46%), Gaps = 21/166 (12%)

Query: 207 TKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPE--------SQEDSETPAEEDSGS 258
           TK   A E  SP    ++PV E A +P  A S    E        S E +++PA+E++ S
Sbjct: 501 TKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS 560

Query: 259 EQPPNSVLPDK--LKVSWENPSPQEA--PAAESAE-PSQAPCSETSEAAPREGGKPPTPP 313
             PP +  P+K   K   E  SP++A  PA E A+ P++A   E +++  +E  K P   
Sbjct: 561 --PPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA 618

Query: 314 PKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAE 359
              + E+ K S  E++     +P   +        SPE AK  + E
Sbjct: 619 KSPVKEEAK-SPAEVK-----SPEKAKSPTKEEAKSPEKAKSPEKE 658



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 49/188 (26%), Positives = 76/188 (40%), Gaps = 19/188 (10%)

Query: 193 EAQPRETPRPLMPPTKPFLAPETTSPG-DRVETPVGERAPTPVSASSEVSPESQEDSETP 251
           E +  ++P  +  P K        SP  +  ++P   ++P    A S    +S E +++P
Sbjct: 534 EKEEAKSPAEVKSPEK------AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSP 587

Query: 252 AEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPA-AESAEPSQAPCSETSEAAPREGGKPP 310
           A+E++ S  P  +  P+K K    +P  +EA + AE+  P +      +E    E  K P
Sbjct: 588 AKEEAKS--PAEAKSPEKAK----SPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641

Query: 311 TPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAK-PSQAEGTPGTPPKDA 369
           T       EK K+   E   S   A   V+        SPE AK P +AE       K  
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAK----SPEKAKSPVKAEAKSPEKAKSP 697

Query: 370 TTSTALPP 377
               A  P
Sbjct: 698 VKEEAKSP 705



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 43/227 (18%), Positives = 84/227 (37%), Gaps = 10/227 (4%)

Query: 239 EVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSET 298
           E     +E    PAEE +  E+   S + ++ K   E  SP++    E+  P++    E 
Sbjct: 493 EAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEK---EEAKSPAEVKSPEK 549

Query: 299 SEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAK-PSQ 357
           +++  +E  K P        E+ K+           +P   +        SPE AK P +
Sbjct: 550 AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVK 609

Query: 358 AEGTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGPRHPLQPRER----LYRAQ 413
            E       K      A  P ++      +  +  +   + P     P +       +A+
Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEE--AKSPEKAKSPEKEEAKSPEKAK 667

Query: 414 LEVKVASEQTEKLLNKVLGSEPAPVSAETLLSQAVEQLRQATQVLQE 460
             VK  ++  EK  + V     +P  A++ + +  +   +A   ++E
Sbjct: 668 SPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE 714


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
            [Homo sapiens]
          Length = 1130

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 77/298 (25%), Positives = 111/298 (37%), Gaps = 45/298 (15%)

Query: 143  DRVRGGQRRRPPTRVHLKEVASAASDGLLRLDLDVPDSGPPVFAPSNHVSEAQPRETPRP 202
            D+V  G    PP  V   E    A+D + +   D+ +S P           + P  TP+P
Sbjct: 773  DQVTRGTVTPPPRLVKKNE---EAADEVFK---DIMESSP---------GSSPPNLTPKP 817

Query: 203  L-----MPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSG 257
            L     + P       E    G  + TP      TP S +   +P     S+ PAEE   
Sbjct: 818  LRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGT--SKGPAEESRV 875

Query: 258  SEQPPNSVLP--DKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPPPK 315
                 +S  P  DK K+S   P+P   PAA + +    P    S+ A  E          
Sbjct: 876  RRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEA--------- 926

Query: 316  ILSEKLKAS----MGEMQASGPPAPGT-VQVSVNGMDDSPEPAKPSQAEGTPGTPPKDAT 370
            +L  K KA+         A+ P  PG  ++  V      P+ AKPS    +P   P    
Sbjct: 927  VLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLP 986

Query: 371  TSTALPPWDLPPQ--FHPRCSSLGDLLGEGPRHPLQPRERLYRAQLEVKVASEQTEKL 426
            ++++    D P    F P  S+   L     R   QP ER+    +   V  + TE L
Sbjct: 987  SASSALAGDQPSSTAFIPLISTRVSL-----RKTRQPPERIASGAITKGVVLDSTEAL 1039


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
            [Homo sapiens]
          Length = 1149

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 77/298 (25%), Positives = 111/298 (37%), Gaps = 45/298 (15%)

Query: 143  DRVRGGQRRRPPTRVHLKEVASAASDGLLRLDLDVPDSGPPVFAPSNHVSEAQPRETPRP 202
            D+V  G    PP  V   E    A+D + +   D+ +S P           + P  TP+P
Sbjct: 792  DQVTRGTVTPPPRLVKKNE---EAADEVFK---DIMESSP---------GSSPPNLTPKP 836

Query: 203  L-----MPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSG 257
            L     + P       E    G  + TP      TP S +   +P     S+ PAEE   
Sbjct: 837  LRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGT--SKGPAEESRV 894

Query: 258  SEQPPNSVLP--DKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPPPK 315
                 +S  P  DK K+S   P+P   PAA + +    P    S+ A  E          
Sbjct: 895  RRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEA--------- 945

Query: 316  ILSEKLKAS----MGEMQASGPPAPGT-VQVSVNGMDDSPEPAKPSQAEGTPGTPPKDAT 370
            +L  K KA+         A+ P  PG  ++  V      P+ AKPS    +P   P    
Sbjct: 946  VLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLP 1005

Query: 371  TSTALPPWDLPPQ--FHPRCSSLGDLLGEGPRHPLQPRERLYRAQLEVKVASEQTEKL 426
            ++++    D P    F P  S+   L     R   QP ER+    +   V  + TE L
Sbjct: 1006 SASSALAGDQPSSTAFIPLISTRVSL-----RKTRQPPERIASGAITKGVVLDSTEAL 1058


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 49/216 (22%), Positives = 75/216 (34%), Gaps = 18/216 (8%)

Query: 182  PPVFAPSNHVSEAQ---PRETPRPLM-----PPTKPFLAPETTSPGDRVETPVGERAPTP 233
            PP   PS  ++      P  TP P +     PP     +P TT+P     TP     PT 
Sbjct: 1433 PPTTTPSPPITTTTTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTP---SPPTT 1489

Query: 234  VSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQA 293
             + +   +      + TP    + +   P +  P     +   P P   P+  +  P   
Sbjct: 1490 TTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITP 1549

Query: 294  PCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPA 353
            P S T+          P+PPP   +     +      +  P+P T+  +      +P P 
Sbjct: 1550 PTSTTTLPPTTT----PSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPP 1605

Query: 354  KPSQAEGTPGTPPKDATTSTALPPWD---LPPQFHP 386
              +     P T P   TT+   PP     LPP   P
Sbjct: 1606 TTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTP 1641



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 46/210 (21%), Positives = 67/210 (31%), Gaps = 7/210 (3%)

Query: 182  PPVFAPSNHVSEAQ-PRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEV 240
            PP   PS   +    P  T  P  P T P   P +T+      TP     PT  +     
Sbjct: 1518 PPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTP--SPPPTTTTTPPPT 1575

Query: 241  SPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSE 300
            +  S   + TP+     +  PP +  P     +   P P   P+  +  P   P S T+ 
Sbjct: 1576 TTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTL 1635

Query: 301  AAPREGGKPP----TPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
                    PP    TPPP         +      +    P       + +  +P P   +
Sbjct: 1636 PPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTT 1695

Query: 357  QAEGTPGTPPKDATTSTALPPWDLPPQFHP 386
                +P T P    T+T  P     P   P
Sbjct: 1696 MTTPSPTTTPSSPITTTTTPSSTTTPSPPP 1725



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 52/206 (25%), Positives = 79/206 (38%), Gaps = 26/206 (12%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 4104 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 4160

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSE-T 298
            V         TP    +G++ P  + +     V+   P+P           S AP +E T
Sbjct: 4161 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTPTGTQTGPPTHTSTAPIAELT 4210

Query: 299  SEAAPREGGKP----PTPPPKILSEKLKASMG---EMQASGPPAPGTVQVSVNGMDDSPE 351
            +   P E   P     T  P   S  L +++    EM ++ PP+  T   + +G      
Sbjct: 4211 TSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPSTPTAPTTTSGGHTLSP 4270

Query: 352  PAKPSQAEGTPGTPPKDATTSTALPP 377
            P  PS     PGTP +  TT ++  P
Sbjct: 4271 P--PSTTTSPPGTPTRGTTTGSSSAP 4294



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 52/189 (27%), Positives = 70/189 (37%), Gaps = 31/189 (16%)

Query: 196  PRETPRPLMPPTKPFLAPETTSPG---DRVETPVGERAPTPVSASSEVSPESQEDSETPA 252
            P  TP P  PPT     P TT+P        TP     P+P   ++   P     + TP+
Sbjct: 1402 PTTTPSP--PPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPP----PTTTPS 1455

Query: 253  EEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTP 312
               S +  PP +  P           P   P+  +  PS  P + T+   P     PPT 
Sbjct: 1456 PPISTTTTPPPTTTPS---------PPTTTPSPPTTTPS-PPTTTTTTPPPTTTPSPPTT 1505

Query: 313  PPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTS 372
             P        AS   +  +  P+P T   +       P    PS    TP TPP   T++
Sbjct: 1506 TP----ITPPASTTTLPPTTTPSPPTTTTTT-----PPPTTTPSPPTTTPITPP---TST 1553

Query: 373  TALPPWDLP 381
            T LPP   P
Sbjct: 1554 TTLPPTTTP 1562



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 47/208 (22%), Positives = 71/208 (34%), Gaps = 15/208 (7%)

Query: 180  SGPPVFAPSNH-VSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASS 238
            S P    PS   ++   P  T  P  P T     P TT+P     TP+    PT  +   
Sbjct: 1579 SPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPI--TPPTSTTTLP 1636

Query: 239  EVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSET 298
              +  S   + T     + +  PP +  P     +   P P   P++        P +  
Sbjct: 1637 PTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTM 1696

Query: 299  SEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQA 358
            +  +P       TP   I +    +S      +  P+P    ++      +P P   +  
Sbjct: 1697 TTPSPTT-----TPSSPITTTTTPSS------TTTPSPPPTTMTTPSPTTTPSPPTTTMT 1745

Query: 359  EGTPGTPPKDATTSTALPPWDLPPQFHP 386
               P T     TT T LPP   PP F P
Sbjct: 1746 TLPPTTTSSPLTT-TPLPPSITPPTFSP 1772



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 46/206 (22%), Positives = 74/206 (35%), Gaps = 32/206 (15%)

Query: 182  PPVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASS 238
            PP   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++
Sbjct: 1895 PPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTT 1951

Query: 239  EVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSET 298
             V         TP    +G++ P  + +     V+   P+P       +  P+  P + T
Sbjct: 1952 TV---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTT 1996

Query: 299  SEAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKP 355
            +   P     G + PT  P   +  +  +      +G   P T  ++      +  P   
Sbjct: 1997 TTVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPT 2050

Query: 356  SQAEGTPGTPPKDATTSTALPPWDLP 381
                 TP T P   TT+T + P   P
Sbjct: 2051 PTGTQTPTTTP--ITTTTTVTPTPTP 2074



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 2034 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 2090

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 2091 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 2135

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 2136 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 2189

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 2190 TGTQTPTTTP--ITTTTTVTPTPTP 2212



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 2172 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 2228

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 2229 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 2273

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 2274 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 2327

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 2328 TGTQTPTTTP--ITTTTTVTPTPTP 2350



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 2310 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 2366

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 2367 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 2411

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 2412 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 2465

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 2466 TGTQTPTTTP--ITTTTTVTPTPTP 2488



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 2448 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 2504

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 2505 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 2549

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 2550 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 2603

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 2604 TGTQTPTTTP--ITTTTTVTPTPTP 2626



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 2586 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 2642

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 2643 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 2687

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 2688 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 2741

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 2742 TGTQTPTTTP--ITTTTTVTPTPTP 2764



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 2724 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 2780

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 2781 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 2825

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 2826 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 2879

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 2880 TGTQTPTTTP--ITTTTTVTPTPTP 2902



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 2862 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 2918

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 2919 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 2963

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 2964 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 3017

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 3018 TGTQTPTTTP--ITTTTTVTPTPTP 3040



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 3000 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 3056

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 3057 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 3101

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 3102 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 3155

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 3156 TGTQTPTTTP--ITTTTTVTPTPTP 3178



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 3138 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 3194

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 3195 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 3239

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 3240 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 3293

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 3294 TGTQTPTTTP--ITTTTTVTPTPTP 3316



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 3276 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 3332

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 3333 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 3377

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 3378 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 3431

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 3432 TGTQTPTTTP--ITTTTTVTPTPTP 3454



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 3414 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 3470

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 3471 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 3515

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 3516 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 3569

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 3570 TGTQTPTTTP--ITTTTTVTPTPTP 3592



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 3552 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 3608

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 3609 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 3653

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 3654 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 3707

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 3708 TGTQTPTTTP--ITTTTTVTPTPTP 3730



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 3690 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 3746

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 3747 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 3791

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 3792 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 3845

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 3846 TGTQTPTTTP--ITTTTTVTPTPTP 3868



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 3828 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 3884

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 3885 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 3929

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 3930 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 3983

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 3984 TGTQTPTTTP--ITTTTTVTPTPTP 4006



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 45/205 (21%), Positives = 73/205 (35%), Gaps = 32/205 (15%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTK-PFLAPETTSPGDRVETPVGERAPT--PVSASSE 239
            P   P    +   P  TP     PT  P     T +P     TP G + PT  P++ ++ 
Sbjct: 3966 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTT 4022

Query: 240  VSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETS 299
            V         TP    +G++ P  + +     V+   P+P       +  P+  P + T+
Sbjct: 4023 V---------TPTPTPTGTQTPTTTPITTTTTVT-PTPTP-----TGTQTPTTTPITTTT 4067

Query: 300  EAAPR---EGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPS 356
               P     G + PT  P   +  +  +      +G   P T  ++      +  P    
Sbjct: 4068 TVTPTPTPTGTQTPTTTPITTTTTVTPT---PTPTGTQTPTTTPITTT---TTVTPTPTP 4121

Query: 357  QAEGTPGTPPKDATTSTALPPWDLP 381
                TP T P   TT+T + P   P
Sbjct: 4122 TGTQTPTTTP--ITTTTTVTPTPTP 4144


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 65/237 (27%), Positives = 92/237 (38%), Gaps = 43/237 (18%)

Query: 173  LDLDVPDSGP----PVFAPSNHVSEAQPRE------------TPRPLMPPTKPFLAPETT 216
            ++L  P  GP    P  AP+  ++ + P++            +P P   PT P   P   
Sbjct: 891  VNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPP-- 948

Query: 217  SPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWEN 276
            SP     TP  + APTP +A+    P  +    TP+ +  G+  PP +  P   K     
Sbjct: 949  SPKGGPATPSPKWAPTPPAATP---PSPKGGPATPSPK--GAPTPP-AATPPSPKGGPAT 1002

Query: 277  PSPQEAPAAESAEPSQAPCSETSEAAPREGGKPP--TPPPKILSEKLKASMGEMQASGPP 334
            PSP+ AP   +  P     S  +   P+    PP  TPP    S K   +   +    P 
Sbjct: 1003 PSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPP----SPKGSPAATPLPKGAPT 1058

Query: 335  APGTVQVSVNG------MDDSPEP--AKPSQAEGTPGTP-PKDATTSTALPPWDLPP 382
             P     S  G      +  +P P  A P   +G P TP PK A     +PP   PP
Sbjct: 1059 TPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGA----PMPPAATPP 1111



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 54/185 (29%), Positives = 70/185 (37%), Gaps = 12/185 (6%)

Query: 199  TPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSGS 258
            TP P   PT P + P +   G    TP  + A TP +A+    P S + S        G+
Sbjct: 1002 TPSPKGAPTPPAVTPPSPK-GSPAATPFPKGASTPPAAT----PPSPKGSPAATPLPKGA 1056

Query: 259  EQPPNSVLPDKLKVSWENPSPQEAP---AAESAEPSQAPCSETSEAAPREGGKPPTPPPK 315
               P + LP   K     PS + AP   AA    P   P + + + AP      P  P  
Sbjct: 1057 PTTPAATLPSP-KGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKG 1115

Query: 316  ILSEKLKASMGEMQASGPPAP--GTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDA-TTS 372
             L+           A+ PP+P  G       G   +P    PS   G    PPK A TT 
Sbjct: 1116 GLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTP 1175

Query: 373  TALPP 377
             A PP
Sbjct: 1176 AATPP 1180



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 63/231 (27%), Positives = 81/231 (35%), Gaps = 42/231 (18%)

Query: 178  PDSGPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSAS 237
            P  G P    +   S      TP P   PT P   P   SP   + TP  + APT  +A+
Sbjct: 1121 PHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPP--SPKGGLATPPPKGAPTTPAAT 1178

Query: 238  SEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSE 297
                P  +    TP+ +  G+   P +  P   K     PSP+ AP   +A P   P  +
Sbjct: 1179 P---PSPKGGLATPSPK--GAPTTP-AATPPSPKGGLATPSPKGAPTTPAATP---PSPK 1229

Query: 298  TSEAAPREGGKPPTP---------------------PPKILSEKLKASMGEMQASGPPAP 336
               A P   G P TP                     PP      LK  +      G P P
Sbjct: 1230 GGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNP 1289

Query: 337  GTV---------QVSVNGMDDSPEPAKPSQAEGTPGT-PPKDATTSTALPP 377
              V           S      +P  A P   +G+PGT PPK A T  A+ P
Sbjct: 1290 AVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTP 1340



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 71/263 (26%), Positives = 92/263 (34%), Gaps = 41/263 (15%)

Query: 180  SGPPVFAPSNHVSEAQPRE--------TPRPLMPPTKPFLAPETTSPGDRVETPVGERAP 231
            S PP   PS +     P+E        +P P   PT P + P +   G     P G    
Sbjct: 1580 SSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTS 1639

Query: 232  TPVSASS-EVSPESQED--SETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAP---AA 285
             PV+ SS + SP S      +  A     S+  P    P  LK     P+P+  P   A 
Sbjct: 1640 PPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAP 1699

Query: 286  ESAEPSQAPCSETS-----EAAPREGGKPP---------TPPPKILSEKLKASMGEMQAS 331
                P     S TS     + + + G K P          P  K  S+  K         
Sbjct: 1700 TRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPK 1759

Query: 332  GPPAPGTVQVSV-------NGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPPWDLPPQF 384
            GP AP   + S          +   PE A  S A   P + P   +    LPP     QF
Sbjct: 1760 GPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPP---KQQF 1816

Query: 385  HPRCSSLGDLLGEGPRHPLQPRE 407
             P  SS G L+ E P  PL P +
Sbjct: 1817 LP--SSPG-LVLESPSKPLAPAD 1836



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 59/220 (26%), Positives = 84/220 (38%), Gaps = 36/220 (16%)

Query: 181  GPPVFAPSNHVSEAQPRETPRPLMP---PTKPFLAPETTSPGDRVETPV-GERAP---TP 233
            GP +  PS     A P     P  P   P  P  AP T    +   TP  G+  P   TP
Sbjct: 1381 GPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTP 1440

Query: 234  VSASSE----------VSPESQEDSETPAEEDSGSEQPP------NSVLPDKLKVSWENP 277
            VS               +P S+ D   PA      ++PP       S  P K   +   P
Sbjct: 1441 VSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPAT---P 1497

Query: 278  SPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPG 337
            +P  AP   +  PS     +   A P     P  P   +LS+K  A++   +A  PPA  
Sbjct: 1498 APMGAPTLPAVIPSSP---KEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPA-- 1552

Query: 338  TVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPP 377
               ++V     +P    P +A  TP +  K+A++  A+ P
Sbjct: 1553 ---MTVPSPKKTPAIPTPKEAPATPSS--KEASSPPAVTP 1587



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 51/185 (27%), Positives = 70/185 (37%), Gaps = 29/185 (15%)

Query: 196  PRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEED 255
            P+ETP P +    PF      +P  +    +   + +P  A +  +P+    S +P    
Sbjct: 882  PKETPTPSVV-NLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSP---- 936

Query: 256  SGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPPPK 315
             G+  PP +  P   K     PSP+ AP   +A P   P  +   A P   G  PTPP  
Sbjct: 937  KGAPTPP-AATPPSPKGGPATPSPKWAPTPPAATP---PSPKGGPATPSPKG-APTPP-- 989

Query: 316  ILSEKLKASMGEMQASGPPAP--GTVQVSVNGMDDSPEPAKPSQAEGTPGTP-PKDATTS 372
                          A+ PP+P  G    S  G    P    PS       TP PK A+T 
Sbjct: 990  --------------AATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTP 1035

Query: 373  TALPP 377
             A  P
Sbjct: 1036 PAATP 1040



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 73/275 (26%), Positives = 94/275 (34%), Gaps = 60/275 (21%)

Query: 178  PDSGPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSAS 237
            P  G P  A     S      T  P   PT P   P   SP     TP  + APTP +  
Sbjct: 1282 PHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPP--SPKGSPGTPPPKGAPTPPA-- 1337

Query: 238  SEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSE 297
              V+P S + + T       S+  P +            PS +E P   +A PS      
Sbjct: 1338 --VTPPSPKGTPTLPATTPSSKGGPTT------------PSSKEGPTPPAATPSHKGGPA 1383

Query: 298  TSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQ 357
             +  +P+ G  P  P PK                 P +P  + +S         PA P  
Sbjct: 1384 MTPPSPKRG--PAIPSPK---------------GDPTSPAVIPLS-----PKKAPATPVT 1421

Query: 358  AEG--TPG----TPPKDATTSTALPPWDLPPQFHPRC-SSLGD--LLGEGPRHPLQPRER 408
             EG  TP     TPP     S    P    P+  P   SS GD  L    P  P +P   
Sbjct: 1422 REGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEP--- 1478

Query: 409  LYRAQLEVKVASEQTEKLLNKVLGSEPAPVSAETL 443
               A  +V  +S        K   + PAP+ A TL
Sbjct: 1479 --PAPKQVATSSSP------KKAPATPAPMGAPTL 1505



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 38/149 (25%), Positives = 63/149 (42%), Gaps = 9/149 (6%)

Query: 161  EVASAASDGLLRLDLDVPDSGPPVFAPSNHVSEAQPR---ETP-RPLMPPTK----PFLA 212
            E AS ++     + L +  S  P   P      + P    E+P +PL P  +    P + 
Sbjct: 1786 ESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIP 1845

Query: 213  PETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKV 272
            PE  S G   ++ V    PTP SA   V   S +   T   + SG+E   +  +P+  + 
Sbjct: 1846 PEPISGGVPFQS-VLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQ 1904

Query: 273  SWENPSPQEAPAAESAEPSQAPCSETSEA 301
                 + Q+A  A +AE  + P S+  ++
Sbjct: 1905 DSTQATTQQAQLAAAAEIDEEPVSKAKQS 1933



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 50/208 (24%), Positives = 75/208 (36%), Gaps = 36/208 (17%)

Query: 196 PRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEED 255
           P+  P P +PP                 TP G +    +S +S ++P +    E P E D
Sbjct: 731 PKSVPSPSLPPAG---------------TPPGTKKVDGISHTSALAPVASSPKECPTE-D 774

Query: 256 SGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPPPK 315
           SG+    +S    K  +++   SP  +P   S  P      +T     ++G   P  P  
Sbjct: 775 SGASATASS----KGTLTYLADSP--SPLGVSVSP------QTKRPPTKKGSAGPDTP-- 820

Query: 316 ILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTAL 375
                L + +  ++AS  P      +S  G  DSP            G P   A T  + 
Sbjct: 821 --IGNLSSPVSPVEASFLPEN---SLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSP 875

Query: 376 PPWDLPPQFHPRCSSLG-DLLGEGPRHP 402
               LPP+  P  S +      EGP  P
Sbjct: 876 KGVTLPPKETPTPSVVNLPFPKEGPATP 903



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 41/157 (26%), Positives = 55/157 (35%), Gaps = 23/157 (14%)

Query: 180  SGPPVFA-PSNHVSEAQPRET--PRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSA 236
            + PP+   PS       P  T  P PL+P  K   + +T    D   +P G  AP    A
Sbjct: 1712 TSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKD--SSKTAKGKDASHSPKGPLAPPESKA 1769

Query: 237  SSEVS----------PESQEDSETPAEEDS--------GSEQPPNSVLPDKLKVSWENPS 278
            S+ ++          PES   S  P+   S         +  P    LP    +  E+PS
Sbjct: 1770 STPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPS 1829

Query: 279  PQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPPPK 315
               APA E       P    S   P +      P PK
Sbjct: 1830 KPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPK 1866


>gi|33356148 formin-like 1 [Homo sapiens]
          Length = 1100

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 49/146 (33%), Positives = 53/146 (36%), Gaps = 38/146 (26%)

Query: 222 VETPVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQE 281
           V TP G  APTP   +   SP    D    AE   G+  PP   LP         PSPQE
Sbjct: 508 VATPSGGDAPTPGVPTGSPSP----DLAPAAEPAPGAAPPPPPPLPGL-------PSPQE 556

Query: 282 APAAESAEPSQAPCS-ETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQ 340
           AP +   +    P S E   A P  G  PP PPP                  PP PGT  
Sbjct: 557 APPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPP-----------------PPPPGT-- 597

Query: 341 VSVNGMDDSPEPAKPSQAEGTPGTPP 366
                  D P P  P      PG PP
Sbjct: 598 -------DGPVPPPPPPPPPPPGGPP 616



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 54/209 (25%), Positives = 78/209 (37%), Gaps = 28/209 (13%)

Query: 214 ETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSGSE---QPPNSVLPDKL 270
           E+T+ G     P  E+AP     ++   P + E      EE         P ++V  + L
Sbjct: 449 ESTAMGASRRPPEPEKAPP----AAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEIL 504

Query: 271 KVSWENPSPQEAPAAESAEPSQAPCSETSEAA-PREGGKPPTPPPKILSEKLKASMGEMQ 329
            V+   PS  +AP      P+ +P  + + AA P  G  PP PPP       + +     
Sbjct: 505 PVAVATPSGGDAPTP--GVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAP 562

Query: 330 ASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPPWDLPPQFHP--- 386
              PP PG+ +         P P  P      P  PP    T   +PP   PP   P   
Sbjct: 563 PQAPPLPGSPE-------PPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGP 615

Query: 387 ------RCSSLGDLLGEGPRHPLQPRERL 409
                 R S LG   G   + P+Q + R+
Sbjct: 616 PDALGRRDSELGP--GVKAKKPIQTKFRM 642



 Score = 33.1 bits (74), Expect = 0.59
 Identities = 50/209 (23%), Positives = 60/209 (28%), Gaps = 42/209 (20%)

Query: 176 DVPDSGPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVS 235
           D P  G P  +PS  ++   P   P P   P  P   P   SP +            P S
Sbjct: 515 DAPTPGVPTGSPSPDLA---PAAEPAPGAAPPPPPPLPGLPSPQE-----------APPS 560

Query: 236 ASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPC 295
           A  +  P        PA    G   PP              P P   P  +   P   P 
Sbjct: 561 APPQAPPLPGSPEPPPAPPLPGDLPPP-------------PPPPPPPPGTDGPVPPPPP- 606

Query: 296 SETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKP 355
                        PP PPP    + L     E+   G  A   +Q        +    KP
Sbjct: 607 -------------PPPPPPGGPPDALGRRDSEL-GPGVKAKKPIQTKFRMPLLNWVALKP 652

Query: 356 SQAEGTPGTPPKDATTSTALPPWDLPPQF 384
           SQ  GT  T   D      L   D   QF
Sbjct: 653 SQITGTVFTELNDEKVLQELDMSDFEEQF 681


>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
          Length = 1271

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 57/184 (30%), Positives = 77/184 (41%), Gaps = 23/184 (12%)

Query: 196 PRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPV-SASSEVSPESQ-EDSETPAE 253
           P   P P  PP  P L+  +  P   +  P  E AP P   A+SE + E   E +  PA 
Sbjct: 31  PPPPPPPAPPPAPPLLSEASPEP---IPEPCPELAPGPCPEATSESATELYTEPTPEPAT 87

Query: 254 EDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESA-EPSQAPCSE---------TSEAAP 303
           E +    P  +  P     +   P P   PA ESA EP+  P  E         T E AP
Sbjct: 88  EPASEPAPEPATEPAPEPATEPAPEPAPEPATESAPEPTPEPALESVPEPAPELTPEVAP 147

Query: 304 REGGKP-PTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVN----GMDDSPEPAKPSQA 358
               +P P P  ++  E    +  E + S  PAP  +Q  V+    G+  SP P+ PS +
Sbjct: 148 ELAPEPTPEPVTELAPEFCPEAAPEFRPS--PAPCLLQCPVDTRERGLKTSPSPS-PSPS 204

Query: 359 EGTP 362
             TP
Sbjct: 205 PRTP 208



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 39/146 (26%), Positives = 51/146 (34%), Gaps = 18/146 (12%)

Query: 246 EDSETPAEEDSGSEQ-----PPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSE 300
           +D E PAE            PP +  P    +S  +P P   P  E A     PC E + 
Sbjct: 15  QDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAP---GPCPEATS 71

Query: 301 AAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEG 360
            +  E    PTP P            E  +   P P T        + +PEPA     E 
Sbjct: 72  ESATELYTEPTPEPAT----------EPASEPAPEPATEPAPEPATEPAPEPAPEPATES 121

Query: 361 TPGTPPKDATTSTALPPWDLPPQFHP 386
            P   P+ A  S   P  +L P+  P
Sbjct: 122 APEPTPEPALESVPEPAPELTPEVAP 147



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 41/138 (29%), Positives = 55/138 (39%), Gaps = 6/138 (4%)

Query: 181 GPPVFAPSNHVSEAQPRETPRPLM-PPTKPFLAPETTSPGDRVETPVGERAPTPVSASS- 238
           GP   A S   +E     TP P   P ++P   P T    +    P  E AP P + S+ 
Sbjct: 64  GPCPEATSESATELYTEPTPEPATEPASEPAPEPATEPAPEPATEPAPEPAPEPATESAP 123

Query: 239 EVSPE-SQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAP-AAESAEPSQAPCS 296
           E +PE + E    PA E +    P   + P+         +P+  P AA    PS APC 
Sbjct: 124 EPTPEPALESVPEPAPELTPEVAP--ELAPEPTPEPVTELAPEFCPEAAPEFRPSPAPCL 181

Query: 297 ETSEAAPREGGKPPTPPP 314
                  RE G   +P P
Sbjct: 182 LQCPVDTRERGLKTSPSP 199



 Score = 30.0 bits (66), Expect = 5.0
 Identities = 30/121 (24%), Positives = 36/121 (29%), Gaps = 26/121 (21%)

Query: 282 APAAESAEPSQAPCSETSEAAPREGGKPPTPP------PKILS----------------- 318
           A AA+   P Q          P     PP PP      P +LS                 
Sbjct: 5   AAAAQGTAPPQDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAPG 64

Query: 319 ---EKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTAL 375
              E    S  E+     P P T   S    + + EPA     E  P   P+ AT S   
Sbjct: 65  PCPEATSESATELYTEPTPEPATEPASEPAPEPATEPAPEPATEPAPEPAPEPATESAPE 124

Query: 376 P 376
           P
Sbjct: 125 P 125


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 49/173 (28%), Positives = 73/173 (42%), Gaps = 16/173 (9%)

Query: 182   PPVFAPSNHVSEAQPRETPRPLMP--PTKPFLAPETTSP-GDRVETPVGE--RAPTPVSA 236
             P    P   V+  +  E P   +P  P KP L  +   P  +R E+P  E    P  ++ 
Sbjct: 10753 PKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAP 10812

Query: 237   SSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSP----QEAPAAESAEPSQ 292
               E++PE  E+   P  E+   E PP +V  +  K+  E   P     EAP  +  EP +
Sbjct: 10813 EEEIAPE--EEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEK 10870

Query: 293   APCSETSEAAPREGGKPPTPPPKILSEK---LKASMGEMQASGPPAPGTVQVS 342
                 E  +  PR    PP PP + + EK   LKA   +     P  P  V+++
Sbjct: 10871 V--IEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELT 10921



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 55/200 (27%), Positives = 77/200 (38%), Gaps = 19/200 (9%)

Query: 182   PPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTS----PGDRVETPVGERAPTPVSAS 237
             P V  P   V EA P   P+P  PP + F  PE  +    P + VE P     P      
Sbjct: 10641 PKVAVPEKKVPEAIP---PKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPP 10697

Query: 238   SEVSPESQED---SETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAP 294
              +  PE +     ++ P        + P  V+P+K KV    P   EAP A+  E  +  
Sbjct: 10698 KKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEK-KVPLVVPKKPEAPPAKVPEVPKEV 10756

Query: 295   CSETSEAAPREGGKPPTPPPK-----ILSEKLKASMGEMQASGPPAPGTVQVSVNGMDD- 348
               E   A P++   PP   P+     +L EK    + E   S PP        +   ++ 
Sbjct: 10757 VPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEI 10816

Query: 349   SPEPAKPSQA--EGTPGTPP 366
             +PE  KP     E  P  PP
Sbjct: 10817 APEEEKPVPVAEEEEPEVPP 10836



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 59/231 (25%), Positives = 81/231 (35%), Gaps = 30/231 (12%)

Query: 178   PDSGPPVFAPSNHVSEAQPRETP--RPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVS 235
             P   P V  P   V E +    P  +P  PP K   AP+   P  +V  P  ++   P +
Sbjct: 10492 PTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPT 10551

Query: 236   ASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPC 295
                EV   +  + + P       E PP  V     +V  E   P   P      P + P 
Sbjct: 10552 KVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVP- 10610

Query: 296   SETSEAAPREGGKPPTPPPK----------------ILSEKLKASMGEMQASGPP----A 335
                 E  P +  K P PPPK                +  +K+  ++     S PP     
Sbjct: 10611 EAPKEVVPEK--KVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEE 10668

Query: 336   PGTVQVSVNGMD--DSPEPAKPSQAEGTP--GTPPKDATTSTALPPWDLPP 382
             P  V +     +  + PEPA P Q    P    P K A    A  P +LPP
Sbjct: 10669 PEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKP-ELPP 10718



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 73/325 (22%), Positives = 119/325 (36%), Gaps = 37/325 (11%)

Query: 177   VPDSGPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPV-- 234
             VP+    VF     +S  + RE  +   P  K  + P+     ++V  P  E AP PV  
Sbjct: 9839  VPEEPKKVFEEKIRISITK-REKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAP-PVRV 9896

Query: 235   -SASSEVSPES-----------------QEDSETPAEEDSGSEQPPNSVLPDKLKVSWEN 276
                  E+ PE                  +E+     EE+  +E+    V+P K+      
Sbjct: 9897  PEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRK 9956

Query: 277   PSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPT-------PPPKILSEKLKASMGEMQ 329
             P P+E       +  +AP ++  E   +   K P        PPP  + E  K  + E +
Sbjct: 9957  PVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEK 10016

Query: 330   ASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPPWDLPPQFHPRCS 389
                 P P   +V          P KP   +  P   PK      A  P ++P +  P   
Sbjct: 10017 V---PVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVP-EVPKKLIPEEK 10072

Query: 390   SLGDLLGEGPRHPLQPRERLYRAQLEVKVASEQTEKLL--NKVLGSEPAPVSAETLLSQA 447
                 +  +    P  P+    R  + V VA  Q E++L   +++  E      E +L + 
Sbjct: 10073 KPTPVPKKVEAPP--PKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEE 10130

Query: 448   VEQLRQATQVLQEMRDLGELSQEAP 472
              E L +  +VL E  ++    +E P
Sbjct: 10131 EEVLPEEEEVLPEEEEIPPEEEEVP 10155



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 61/237 (25%), Positives = 83/237 (35%), Gaps = 45/237 (18%)

Query: 177   VPDSGPPVFAPSN-HVSEAQPRETPRPLMP----PT---KPFLAPETTSPGDRVETPVGE 228
             VP+   PV AP       A+  E P+ L+P    PT   K   AP    P  R   PV  
Sbjct: 10040 VPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPV 10099

Query: 229   RAPTP--VSASSEVSPESQ----EDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEA 282
               P    V    E+ PE +    E+   P EE+   E+    VLP++ ++    P  +E 
Sbjct: 10100 ALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEE--EEVLPEEEEIP---PEEEEV 10154

Query: 283   PAAESAEPSQAPCSETSEAAPREGGKPPTPPP------KILSEKLKASMGEMQASGPPA- 335
             P  E   P +       E  P    K P P P      K+  +K+     E     PPA 
Sbjct: 10155 PPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKE---EAPPAK 10211

Query: 336   ---------------PGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPP 377
                            P   +V    + + PE  +P   E  P  PP         PP
Sbjct: 10212 VPEVPKKVEEKRIILPKEEEVLPVEVTEEPE-EEPISEEEIPEEPPSIEEVEEVAPP 10267



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 74/303 (24%), Positives = 111/303 (36%), Gaps = 45/303 (14%)

Query: 199  TPRPLMPPTKPFLAPET------TSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPA 252
            T + ++   K F A  T      T P  + E    E+    +S   E  P+  E  E PA
Sbjct: 9237 TKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPA 9296

Query: 253  EEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTP 312
             E+      P  V P   KV    P   + P  E  +P   P  E   AAP    K P  
Sbjct: 9297 PEEVAPVPIPKKVEPPAPKV----PEVPKKPVPEEKKPVPVPKKEP--AAPP---KVPEV 9347

Query: 313  PPK-ILSEKLKASMGEMQASGPPAPGTVQ---------VSVNGMDDSPEPAKPSQAEGTP 362
            P K +  EK+   + + + + P     VQ           V   ++SP PA P      P
Sbjct: 9348 PKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPE----IP 9403

Query: 363  GTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGPRHPLQPRERLYRAQLEVKVASEQ 422
                 +          ++PP   P+  +L       P+ P+ P E++       K A   
Sbjct: 9404 KKKVPEERKPVPRKEEEVPPP--PKVPAL-------PKKPV-PEEKVAVPVPVAKKAPPP 9453

Query: 423  TEKLLNKVLGSEPAPVSAETLLSQAVEQLRQATQVLQEMRDLGELSQEAPGL-----REK 477
              ++  K +  E   V AE  LS AV Q  + T+      +    S+E  G+     RE+
Sbjct: 9454 RAEVSKKTVVEEKRFV-AEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREE 9512

Query: 478  RKE 480
             +E
Sbjct: 9513 ERE 9515



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 52/227 (22%), Positives = 85/227 (37%), Gaps = 45/227 (19%)

Query: 182   PPVFAPSNHVSEA--QPRETPRPLMP-----PTKPFLAPETTSPGDR-VETPVGERAPTP 233
             PP   P   V E   Q +  P+  +P     P K  L P     G++ V   + ER P P
Sbjct: 10884 PPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEP 10943

Query: 234   VSA--------------SSEVSPESQEDSETPAEEDSGSEQPPNSV-LPDKLKVSWENPS 278
                                +V P+  E  + PA  +    +P   V +P   K   + P 
Sbjct: 10944 KEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPE 11003

Query: 279   PQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPPPK-----------ILSEKLKASMGE 327
             P + P  + A P  AP  +    A  +  KPP   P+           ++ +K +A   +
Sbjct: 11004 PTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPK 11063

Query: 328   MQASGPPAPGTVQVSVNGM-DDSPEPAKPSQAEGTPGT----PPKDA 369
              +A+ P  P      + G+   +P P +  + +  PG+    PP +A
Sbjct: 11064 EEAAKPKGP------IKGVPKKTPSPIEAERRKLRPGSGGEKPPDEA 11104



 Score = 33.9 bits (76), Expect = 0.34
 Identities = 42/149 (28%), Positives = 57/149 (38%), Gaps = 31/149 (20%)

Query: 177   VPDSGPP-----VFAPSNHVSEAQ-PRETPRPLMPPTKPFLAPETT-SPGDRVET---PV 226
             VP+  PP     V  P+    E + P  T  P + P  P  APE    P   V+T   P 
Sbjct: 10977 VPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPP 11036

Query: 227   GERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAE 286
              E  PTP++A   V    ++      +E++   + P   +P K       PSP EA    
Sbjct: 11037 VEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKK------TPSPIEA---- 11086

Query: 287   SAEPSQAPCSETSEAAPREGG-KPPTPPP 314
                       E  +  P  GG KPP   P
Sbjct: 11087 ----------ERRKLRPGSGGEKPPDEAP 11105



 Score = 33.5 bits (75), Expect = 0.45
 Identities = 50/230 (21%), Positives = 75/230 (32%), Gaps = 35/230 (15%)

Query: 178   PDSGPPVFAPSNHVSEAQPRETPRPLMPPTKP-----------------FLAPETTSPGD 220
             P++ PP       V E +P+  PRP  PP  P                    PE     +
Sbjct: 10858 PEAPPPKEPEPEKVIE-KPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPE 10916

Query: 221   RVE-----TPVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWE 275
             +VE      P GE+    +    +  P+ +   ++   +    E+P   V P KL+   +
Sbjct: 10917 KVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEP--KVEPKKLE-KVK 10973

Query: 276   NPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPP---------TPPPKILSEKLKASMG 326
              P+  E P  +  E  + P     E    E  K P          P PK   E    ++ 
Sbjct: 10974 KPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIK 11033

Query: 327   EMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALP 376
                    P P    V+V  +    E   P +    P  P K     T  P
Sbjct: 11034 PPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSP 11083



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 48/227 (21%), Positives = 82/227 (36%), Gaps = 19/227 (8%)

Query: 234  VSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEP--- 290
            VS S     E +E+ E    E    E+P   V+ +KL +  +    + A   E  E    
Sbjct: 9504 VSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIV 9563

Query: 291  ---------SQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQV 341
                      + P ++  EA  +   +   P P    EK+       +   P     V  
Sbjct: 9564 LKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPP 9623

Query: 342  SVNGMDDSPEPAKPSQ--AEGTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGP 399
             V  M++ P PAK ++   + T       A T    PP    P+   R      +L   P
Sbjct: 9624 KVIKMEE-PLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKP 9682

Query: 400  RHPLQPRERLYRAQLEVKVASEQTEKLLNKVLGSEPAPVSAETLLSQ 446
            +   +P  ++   +   +V  E  EK+  +    EP P+   T++ +
Sbjct: 9683 KREEEPPAKV--TEFRKRVVKE--EKVSIEAPKREPQPIKEVTIMEE 9725



 Score = 30.8 bits (68), Expect = 2.9
 Identities = 34/159 (21%), Positives = 57/159 (35%), Gaps = 25/159 (15%)

Query: 205  PPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNS 264
            PP K   AP+   P  +V  PV ++   P        P+  E+ + P         P   
Sbjct: 9576 PPAKVPEAPKKIVPEKKVPAPVPKKEKVP-------PPKVPEEPKKPV--------PEKK 9620

Query: 265  VLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPPPKILSEKLKAS 324
            V P  +K+    P+       +  +  +   + T + AP +   P  P   +  EK+   
Sbjct: 9621 VPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKV-LK 9679

Query: 325  MGEMQASGPPAPGT---------VQVSVNGMDDSPEPAK 354
            +   +   PPA  T          +VS+      P+P K
Sbjct: 9680 LKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIK 9718



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 35/163 (21%), Positives = 54/163 (33%), Gaps = 9/163 (5%)

Query: 243   ESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAA 302
             E  E  E P     G E     + P K         P++ P A+  E  +    E     
Sbjct: 10428 EEVEVFEKPKAPPKGPEISEKIIPPKKPPTK---VVPRKEPPAKVPEVPKKIVVEEKVRV 10484

Query: 303   PREGGKPPTPPPKILSEK-----LKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQ 357
             P E   PPT  P++L  K      K  +   +    P P   +     + +   P  P +
Sbjct: 10485 PEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPK 10544

Query: 358   AEGTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGPR 400
                 P T   +     A+P   +P    P+  S    + E P+
Sbjct: 10545 KPEVPPTKVPE-VPKAAVPEKKVPEAIPPKPESPPPEVPEAPK 10586


>gi|19913398 smoothelin isoform a [Homo sapiens]
          Length = 940

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 81/324 (25%), Positives = 125/324 (38%), Gaps = 53/324 (16%)

Query: 98  KFQAPTGEEKESWIKALNEGINR--------GKNKAFDEVKVDKSC---ALEHVTRDRVR 146
           +F+A   + KE+W+ +      +        G+ ++ ++V+   +    A E+  R  +R
Sbjct: 53  RFRAERQDNKENWLHSQQREAEQRAALARLAGQLESMNDVEELTALLRSAGEYEERKLIR 112

Query: 147 GGQRRRPPTRVHLKEVASAASDGLLRLDLDVPDSGPP-----VFAPSNHVSEAQPRETPR 201
              RR     V  +E+ +A   G  RL    P+SG       + A      E   RE   
Sbjct: 113 AAIRR-----VRAQEIEAATLAG--RLYSGRPNSGSREDSKGLAAHRLEQCEVPEREEQE 165

Query: 202 PLMPPTKPFLAPETTSPGDRVET-----PVGERAPTPVSASSEVSPESQEDSETPAEEDS 256
                +KP   PE TS      T     P G  + +P S SS  +P S E    PAE   
Sbjct: 166 QQAEVSKPTPTPEGTSQDVTTVTLLLRAPPGSTSSSPASPSSSPTPASPEPPLEPAEAQC 225

Query: 257 GSEQPPNSVLPDKLKVSWENPSPQEAPAAESAE----------PSQAPCSETSEAAPRE- 305
            + + P S  P        +P PQE+P   S E          P + P +++    P + 
Sbjct: 226 LTAEVPGSPEPPPSPPKTTSPEPQESPTLPSTEGQVVNKLLSGPKETPAAQSPHRGPSDT 285

Query: 306 ------GGKPPTPPPKILSEKLKASMGEMQ--ASGPPA---PGTVQVSVNGM-DDSPEPA 353
                 G +P      +LS +  A   E    ASGP +    G+V+  V+    DSP  A
Sbjct: 286 KRADVAGPRPCQRSLSVLSPRQPAQNRESTPLASGPSSFQRAGSVRDRVHKFTSDSPMAA 345

Query: 354 KPSQAEGTPGTPPKDATTSTALPP 377
           +    +GTP       T +  L P
Sbjct: 346 R--LQDGTPQAALSPLTPARLLGP 367


>gi|19913396 smoothelin isoform b [Homo sapiens]
          Length = 915

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 81/324 (25%), Positives = 125/324 (38%), Gaps = 53/324 (16%)

Query: 98  KFQAPTGEEKESWIKALNEGINR--------GKNKAFDEVKVDKSC---ALEHVTRDRVR 146
           +F+A   + KE+W+ +      +        G+ ++ ++V+   +    A E+  R  +R
Sbjct: 53  RFRAERQDNKENWLHSQQREAEQRAALARLAGQLESMNDVEELTALLRSAGEYEERKLIR 112

Query: 147 GGQRRRPPTRVHLKEVASAASDGLLRLDLDVPDSGPP-----VFAPSNHVSEAQPRETPR 201
              RR     V  +E+ +A   G  RL    P+SG       + A      E   RE   
Sbjct: 113 AAIRR-----VRAQEIEAATLAG--RLYSGRPNSGSREDSKGLAAHRLEQCEVPEREEQE 165

Query: 202 PLMPPTKPFLAPETTSPGDRVET-----PVGERAPTPVSASSEVSPESQEDSETPAEEDS 256
                +KP   PE TS      T     P G  + +P S SS  +P S E    PAE   
Sbjct: 166 QQAEVSKPTPTPEGTSQDVTTVTLLLRAPPGSTSSSPASPSSSPTPASPEPPLEPAEAQC 225

Query: 257 GSEQPPNSVLPDKLKVSWENPSPQEAPAAESAE----------PSQAPCSETSEAAPRE- 305
            + + P S  P        +P PQE+P   S E          P + P +++    P + 
Sbjct: 226 LTAEVPGSPEPPPSPPKTTSPEPQESPTLPSTEGQVVNKLLSGPKETPAAQSPTRGPSDT 285

Query: 306 ------GGKPPTPPPKILSEKLKASMGEMQ--ASGPPA---PGTVQVSVNGM-DDSPEPA 353
                 G +P      +LS +  A   E    ASGP +    G+V+  V+    DSP  A
Sbjct: 286 KRADVAGPRPCQRSLSVLSPRQPAQNRESTPLASGPSSFQRAGSVRDRVHKFTSDSPMAA 345

Query: 354 KPSQAEGTPGTPPKDATTSTALPP 377
           +    +GTP       T +  L P
Sbjct: 346 R--LQDGTPQAALSPLTPARLLGP 367


>gi|19913394 smoothelin isoform c [Homo sapiens]
          Length = 917

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 81/324 (25%), Positives = 125/324 (38%), Gaps = 53/324 (16%)

Query: 98  KFQAPTGEEKESWIKALNEGINR--------GKNKAFDEVKVDKSC---ALEHVTRDRVR 146
           +F+A   + KE+W+ +      +        G+ ++ ++V+   +    A E+  R  +R
Sbjct: 53  RFRAERQDNKENWLHSQQREAEQRAALARLAGQLESMNDVEELTALLRSAGEYEERKLIR 112

Query: 147 GGQRRRPPTRVHLKEVASAASDGLLRLDLDVPDSGPP-----VFAPSNHVSEAQPRETPR 201
              RR     V  +E+ +A   G  RL    P+SG       + A      E   RE   
Sbjct: 113 AAIRR-----VRAQEIEAATLAG--RLYSGRPNSGSREDSKGLAAHRLEQCEVPEREEQE 165

Query: 202 PLMPPTKPFLAPETTSPGDRVET-----PVGERAPTPVSASSEVSPESQEDSETPAEEDS 256
                +KP   PE TS      T     P G  + +P S SS  +P S E    PAE   
Sbjct: 166 QQAEVSKPTPTPEGTSQDVTTVTLLLRAPPGSTSSSPASPSSSPTPASPEPPLEPAEAQC 225

Query: 257 GSEQPPNSVLPDKLKVSWENPSPQEAPAAESAE----------PSQAPCSETSEAAPRE- 305
            + + P S  P        +P PQE+P   S E          P + P +++    P + 
Sbjct: 226 LTAEVPGSPEPPPSPPKTTSPEPQESPTLPSTEGQVVNKLLSGPKETPAAQSPTRGPSDT 285

Query: 306 ------GGKPPTPPPKILSEKLKASMGEMQ--ASGPPA---PGTVQVSVNGM-DDSPEPA 353
                 G +P      +LS +  A   E    ASGP +    G+V+  V+    DSP  A
Sbjct: 286 KRADVAGPRPCQRSLSVLSPRQPAQNRESTPLASGPSSFQRAGSVRDRVHKFTSDSPMAA 345

Query: 354 KPSQAEGTPGTPPKDATTSTALPP 377
           +    +GTP       T +  L P
Sbjct: 346 R--LQDGTPQAALSPLTPARLLGP 367


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
           sapiens]
          Length = 1560

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 68/238 (28%), Positives = 87/238 (36%), Gaps = 32/238 (13%)

Query: 186 APSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPT-PVSASSEVSPES 244
           AP+  +  A P + P P   P+ P  AP   SP   + +P   R P+ P S    V   S
Sbjct: 757 APAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSP--HLPSPHPTRPPSRPPSRPQSV---S 811

Query: 245 QEDSETPAEEDSGSEQPPN----SVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSE 300
           +  SE P       + PP      V+ ++L V    P P   PA  +  P Q P    S+
Sbjct: 812 RPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGV----PPPASNPAPTAPGPPQPPLRPQSQ 867

Query: 301 AAPREGGKPPTP--PPKILSEKLKASMGEMQASGPPAPGTVQVSV---NGMDDSPEPAKP 355
             P EG  PP P  PP   S  + +S         P P   Q+      G   SP P   
Sbjct: 868 --PPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFPPSQGPHKSPTPPPT 925

Query: 356 SQAEGTPGTPPKD--------ATTSTALP-PWDLPPQFH--PRCSSLGDLLGEGPRHP 402
                 P  PP           T   ALP P  L  +FH  P    L +  G  P  P
Sbjct: 926 LHLVPEPAAPPPPPPRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAP 983



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 59/234 (25%), Positives = 84/234 (35%), Gaps = 49/234 (20%)

Query: 233  PVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKV----SWENPSPQEAPAAESA 288
            P++ASSE          + +   + ++ PP+  LP KL +    +  +PS   A A+ S 
Sbjct: 1211 PIAASSEGHRLPGHGPLSSSAPGASTQPPPH--LPTKLVIRHGGAGGSPSVTWARASSSL 1268

Query: 289  EPSQAPCSETSEAAPREGGKPPT---PPPKI--------LSEKLKASMGEMQA------- 330
              S +  S  S     E G  P+   PP K         L  K+K   G  +        
Sbjct: 1269 SSSSSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLSKVVHNTALD 1328

Query: 331  ---SGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPPWDLPPQFHPR 387
                 PP P T++V+       P P    Q  GT   PP  A            P+  P 
Sbjct: 1329 PVHQPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAA------------PERKP- 1375

Query: 388  CSSLGDLLGEGPRHPLQPRERLYRAQLEVKVASEQTEKLLNKVLGSEPAPVSAE 441
                   LG  P  P  P  + YR  +    A E T     +  G  PAP+ A+
Sbjct: 1376 -------LGTAPHCPRLPLRKTYRENVGGPGAPEGTP--AGRARGGSPAPLPAK 1420



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 60/220 (27%), Positives = 84/220 (38%), Gaps = 30/220 (13%)

Query: 194 AQPRETPRPLMPPTK--PFLAPETTSPGDRVETP----VGERA--PTPVS-ASSEVSPES 244
           A P  T + L  P    P LAP + +    + +     VG+ A    PVS A+  +  +S
Sbjct: 511 ANPILTNQNLAGPLSLGPVLAPHSGAHSAHILSAAPIQVGQPALFQMPVSLAAGSLPTQS 570

Query: 245 QEDSETPAEED--SGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAA 302
           Q     PA      G   PP++V           P     PA         P + T EAA
Sbjct: 571 QPAPAGPAATTVLQGVTLPPSAV------AMLNTPDGLVQPAT--------PAAATGEAA 616

Query: 303 PREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPA---KPSQAE 359
           P    +P    P  +S  L   + + QA  PP   T Q +      +P+P+     S  +
Sbjct: 617 PVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQATTPQPSPGLASSPEK 676

Query: 360 GTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGP 399
              G PP  + T TA+   D    F P+  S   L  EGP
Sbjct: 677 IVLGQPP--SATPTAILTQDSLQMFLPQERSQQPLSAEGP 714



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 67/283 (23%), Positives = 98/283 (34%), Gaps = 61/283 (21%)

Query: 163 ASAASDGLLRLDLDVPDSGPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRV 222
           A+A  +    L +      PP  +    +   QP+    P  P  +    P+ T+P    
Sbjct: 609 AAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQATTP---- 664

Query: 223 ETPVGERAPTPVSASS-EVSPESQEDSETPAE---EDS--------GSEQP-----PNSV 265
                   P+P  ASS E     Q  S TP     +DS         S+QP     P+  
Sbjct: 665 -------QPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLS 717

Query: 266 LPDKLKVSWENPSPQEAPA------------AESAEPSQAPCSETSEAAPREGGKPPTPP 313
           +P  + VS   P+   APA            A  ++ S AP  +   AAP +G  P + P
Sbjct: 718 VPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSP 777

Query: 314 PKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTST 373
               S   +A +G+      P P            S  P++P      P  PP       
Sbjct: 778 ----SLPHQAPLGDSPHLPSPHP--------TRPPSRPPSRPQSVSRPPSEPPLHPCPPP 825

Query: 374 ALPPWDLPPQF--------HPRCSSLGDLLGEGPRHPLQPRER 408
             PP  LP  F         P  S+        P+ PL+P+ +
Sbjct: 826 QAPP-TLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQ 867



 Score = 37.0 bits (84), Expect = 0.041
 Identities = 47/210 (22%), Positives = 69/210 (32%), Gaps = 24/210 (11%)

Query: 172  RLDLDVPDSGPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAP 231
            +L +  P S P   AP       +P+  P     P  P L P +TS      +    R P
Sbjct: 840  QLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLP 899

Query: 232  TPVSASSEVS-PESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEP 290
             P  +  ++  P SQ   ++P      +  P   ++P+        P+    P   + + 
Sbjct: 900  APTPSDFQLQFPPSQGPHKSP------TPPPTLHLVPE--------PAAPPPPPPRTFQM 945

Query: 291  SQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQAS---GPPAPGTVQVSVNGMD 347
               P     +           P   IL  K   +    Q S   GP       V V+G  
Sbjct: 946  VTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPAASVLVSGQA 1005

Query: 348  DSPEPAKPSQAEGTPGTPPKDATTSTALPP 377
             S  P  PS A      P      +T LPP
Sbjct: 1006 PSGTPTAPSHA------PAPAPMAATGLPP 1029



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 38/145 (26%), Positives = 48/145 (33%), Gaps = 32/145 (22%)

Query: 260  QPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREG--GKPPTPPPKIL 317
            QPP    P  LKV+   P P+  P                 AAP     G  P  P   L
Sbjct: 1332 QPPPP--PATLKVA--EPPPRPPPPPPPTGQMNGTVDHPPPAAPERKPLGTAPHCPRLPL 1387

Query: 318  SEKLKASMGEMQASGPPAP-GTVQVSVNGMDDSPEPAKPSQA------------------ 358
             +  + ++G     GP AP GT      G   +P PAK  +A                  
Sbjct: 1388 RKTYRENVG-----GPGAPEGTPAGRARGGSPAPLPAKVDEATSGLIRELAAVEDELYQR 1442

Query: 359  --EGTPGTPPKDATTSTALPPWDLP 381
              +G P  P   A   T  P W+ P
Sbjct: 1443 MLKGPPPEPAASAAQGTGDPDWEAP 1467


>gi|83921602 solute carrier family 38, member 10 isoform a [Homo
           sapiens]
          Length = 1119

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 57/200 (28%), Positives = 78/200 (39%), Gaps = 35/200 (17%)

Query: 182 PPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPT-PVSASSEV 240
           PPV      V E Q RE P    PP++          G +     G+ AP  P S   + 
Sbjct: 499 PPVPHDKVVVDEGQDREVPEENKPPSR--------HAGGKAPGVQGQMAPPLPDSEREKQ 550

Query: 241 SPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSE 300
            PE  E  + P +  +  E      LP+          PQ+ P A+  +P+  P  E  +
Sbjct: 551 EPEQGEVGKRPGQAQALEEAGD---LPE---------DPQKVPEADG-QPAVQPAKE--D 595

Query: 301 AAPREGGKPPTPPPKILSEK---LKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQ 357
             P + G  P P   +LSE+   L    GE    GPP PG      N   D+ +PA+ S 
Sbjct: 596 LGPGDRGLHPRPQA-VLSEQQNGLAVGGGEKAKGGPP-PG------NAAGDTGQPAEDSD 647

Query: 358 AEGTPGTPPKDATTSTALPP 377
             G P  P +       LPP
Sbjct: 648 HGGKPPLPAEKPAPGPGLPP 667



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 65/266 (24%), Positives = 93/266 (34%), Gaps = 49/266 (18%)

Query: 193 EAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPA 252
           E + RET   L P     L P   +PG R         P P   S +++  S E SE P 
Sbjct: 766 EGKARETVENLPPLP---LDPVLRAPGGR---------PAP---SQDLNQRSLEHSEGPV 810

Query: 253 EEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTP 312
             D     PP+   PD        P   +A   +  + +    + T +  P+   + P P
Sbjct: 811 GRDPAG--PPDGG-PDT------EPRAAQAKLRDGQKDAAPRAAGTVKELPKGPEQVPVP 861

Query: 313 PPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTS 372
            P       + + G  +      PG  Q    G  D  +P K   A GT  +  K+A   
Sbjct: 862 DPA------REAGGPEERLAEEFPGQSQDVTGGSQDRKKPGKEVAATGT--SILKEANWL 913

Query: 373 TALP------PWDLPPQFHPRCSSLGDLLGEGPRHPLQPRERLYRAQLEV----KVASEQ 422
            A P      P   P Q         DL G       QP+  L + +L V    +   +Q
Sbjct: 914 VAGPGAETGDPRMKPKQVSRDLGLAADLPGGAEGAAAQPQAVLRQPELRVISDGEQGGQQ 973

Query: 423 TEKL-------LNKVLGSEPAPVSAE 441
             +L       + K  G +  PVS E
Sbjct: 974 GHRLDHGGHLEMRKARGGDHVPVSHE 999


>gi|20070376 solute carrier family 38, member 10 isoform b [Homo
           sapiens]
          Length = 780

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 57/200 (28%), Positives = 78/200 (39%), Gaps = 35/200 (17%)

Query: 182 PPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPT-PVSASSEV 240
           PPV      V E Q RE P    PP++          G +     G+ AP  P S   + 
Sbjct: 499 PPVPHDKVVVDEGQDREVPEENKPPSR--------HAGGKAPGVQGQMAPPLPDSEREKQ 550

Query: 241 SPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSE 300
            PE  E  + P +  +  E      LP+          PQ+ P A+  +P+  P  E  +
Sbjct: 551 EPEQGEVGKRPGQAQALEEAGD---LPE---------DPQKVPEADG-QPAVQPAKE--D 595

Query: 301 AAPREGGKPPTPPPKILSEK---LKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQ 357
             P + G  P P   +LSE+   L    GE    GPP PG      N   D+ +PA+ S 
Sbjct: 596 LGPGDRGLHPRPQA-VLSEQQNGLAVGGGEKAKGGPP-PG------NAAGDTGQPAEDSD 647

Query: 358 AEGTPGTPPKDATTSTALPP 377
             G P  P +       LPP
Sbjct: 648 HGGKPPLPAEKPAPGPGLPP 667


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 55/230 (23%), Positives = 86/230 (37%), Gaps = 32/230 (13%)

Query: 181 GPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPT--PVSASS 238
           GP   A    V +  P + P P  PPT+    P+  +    +++P     PT  PV    
Sbjct: 387 GPKALAQPPGVGKT-PAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPG 445

Query: 239 EVS-PESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSE 297
               P  Q      + + +G  +PP+ +           P P + P  +   P++ P  +
Sbjct: 446 PGKIPAQQAGPGKTSAQQTGPTKPPSQL-----------PGPAKPPPQQPG-PAKPPPQQ 493

Query: 298 TSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPA--PGTVQVSVNGMDDSPEPAKP 355
              A P       T PP       K S  +  ++ PP+  PG+ + S       P PAKP
Sbjct: 494 PGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSA----QQPSPAKP 549

Query: 356 SQAE----------GTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLL 395
           S  +          G P  PP  + ++   P   LP    P C++   LL
Sbjct: 550 SAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLL 599



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 59/219 (26%), Positives = 79/219 (36%), Gaps = 30/219 (13%)

Query: 180 SGPPVFAPSNHVSEAQP----RETPRPLMPPTKP--FLAPETTSPGDRVETPV---GERA 230
           S PP+  P+     AQ     +  P P  PP +P     P    PG  V+ PV   G   
Sbjct: 302 SKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGT-VKPPVQPPGTTK 360

Query: 231 PTPVSASSEVSPESQEDSETPAEEDSGSE---QPPNSVLPDKLKVSWENPSPQEAPAAES 287
           P          P  Q  SE P+ E  G +   QPP        K   + P P + P  + 
Sbjct: 361 PPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVG-----KTPAQQPGPAKPPTQQV 415

Query: 288 AEP---SQAPCSETSEAAPREGGKPPTP-----PPKILSEKLKASMGEMQASGPPAPGT- 338
             P   +Q P  ++   AP   G   TP     P KI +++        Q +GP  P + 
Sbjct: 416 GTPKPLAQQPGLQSPAKAP---GPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQ 472

Query: 339 VQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPP 377
           +          P PAKP   +     PP     ST  PP
Sbjct: 473 LPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPP 511



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 55/224 (24%), Positives = 78/224 (34%), Gaps = 42/224 (18%)

Query: 193  EAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSET-- 250
            +AQ + +P+P     KP      T PG R     G+  PTP     + SP+ QE S    
Sbjct: 857  KAQTKMSPKP---DAKPMPKGSPTPPGPR--PTAGQTVPTP-----QQSPKPQEQSRRFS 906

Query: 251  ---PAEEDSGSEQP--PNSVLPDKL----------------KVSWENPSPQEAPAA---E 286
                +  D+   QP  P   +  KL                      P  Q  P A   +
Sbjct: 907  LNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQ 966

Query: 287  SAEPSQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGM 346
            +  PSQ P   TS+  P+  G+ P  P K +  K +      +   P A     V     
Sbjct: 967  APAPSQPP---TSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTET 1023

Query: 347  DDSPEPAKPSQAEGTPGTPPKDATTSTALPPWDLPPQFHPRCSS 390
            +  P P K S+   +    P+ A   T L     P    P C +
Sbjct: 1024 EKKPPPIKDSK---SLTAEPQKAVLPTKLEKSPKPESTCPLCKT 1064



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 64/273 (23%), Positives = 99/273 (36%), Gaps = 28/273 (10%)

Query: 149 QRRRPPT--RVHLKEVASAASDGLLRLDLDVPDSGPPVFAPSNHVSEAQPRETPRPLMPP 206
           Q  RPP   R     ++ + +    R +  +P   P   +     S    +E  +  M P
Sbjct: 95  QSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMP 154

Query: 207 TKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVL 266
              FL+         V + V +  P  + + SE S E     +   +++ G    P  ++
Sbjct: 155 G--FLSEVNALSA--VSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGK---PEGII 207

Query: 267 PDKLKVSWENPSP-QEAPAAESAEPSQAPCSETSE------AAPREGGKP---PTPPPKI 316
              L+     P P Q+ P  +  +    P S +S+      + P   GKP   PT  P+ 
Sbjct: 208 KPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQT 267

Query: 317 LSEKLKASMGEMQASGPPAPGTVQVSVNGMDDS-PEPAKPSQAEGTPGTPPKDATTSTAL 375
              KL     +  AS P       V    +  S P P+KP   + TPG PP         
Sbjct: 268 DHAKLPL---QRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKS 324

Query: 376 PPWDLPPQFHPRCSSLGDLLGEGP---RHPLQP 405
            P    P   P  S L   L + P   + P+QP
Sbjct: 325 QPGPAKPPAQP--SGLTKPLAQQPGTVKPPVQP 355



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 56/238 (23%), Positives = 83/238 (34%), Gaps = 20/238 (8%)

Query: 178 PDSGPP-VFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGE---RAPTP 233
           P   PP V  P+ H S +   + P      +KP    E + P ++ + PV +   + P  
Sbjct: 700 PKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKM 759

Query: 234 VSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQA 293
           V  ++++   S   ++          Q      P  LK     PS    P  E   P   
Sbjct: 760 VKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP-PLKTDSAKPSQSFPPTGEKVSPFD- 817

Query: 294 PCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPA 353
                S+A PR     P    KI+S    +S  + Q    P     +        SP+P 
Sbjct: 818 -----SKAIPR-----PASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPD 867

Query: 354 KPSQAEGTPGTP-PKDATTSTALPPWDLP-PQFHPRCSS--LGDLLGEGPRHPLQPRE 407
                +G+P  P P+     T   P   P PQ   R  S  LG +       P  P+E
Sbjct: 868 AKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQE 925



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 66/305 (21%), Positives = 116/305 (38%), Gaps = 58/305 (19%)

Query: 211 LAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKL 270
           LAP  +SP  +++T        PV+ +S VS  S +  +T  ++D+  +Q  +       
Sbjct: 650 LAPVPSSPQPKLKT-------APVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKA----- 697

Query: 271 KVSWENPSPQEA-PAAESAEPSQAPCSETSEAAPREGGKPPTPP--PKILSEKLKASMGE 327
                 P P++  P  +      +P ++  +    +    P PP  P + SE+ KA + +
Sbjct: 698 ------PEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVAD 751

Query: 328 MQASGPP--APGTVQVSVNGMDDSPE-PAKPSQAEGTPGTPPKDATTSTALPPWDLPPQ- 383
            +   P    P T  VS +     P+ P+   Q++    T P    T +A P    PP  
Sbjct: 752 DKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP-PLKTDSAKPSQSFPPTG 810

Query: 384 ---------------------FHPRCSSLGDLLGEGPRHPLQPRERLYRAQLEVKVASEQ 422
                                 HP  SS  +  G+    P+Q +E   +AQ   K++ + 
Sbjct: 811 EKVSPFDSKAIPRPASDSKIISHPGPSS--ESKGQKQVDPVQKKEEPKKAQ--TKMSPKP 866

Query: 423 TEKLLNKVLGSEPAPVSAETLLSQAVEQLRQATQVLQEMR----DLGELSQEAPGLREKR 478
             K + K     P P        Q V   +Q+ +  ++ R    +LG ++          
Sbjct: 867 DAKPMPK---GSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTP 923

Query: 479 KELVT 483
           +E VT
Sbjct: 924 QETVT 928



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 68/295 (23%), Positives = 105/295 (35%), Gaps = 41/295 (13%)

Query: 175  LDVPDSGPPVFAPSNHVSEAQPRETPRPLMPPT--KPFLAPETTSPGDRVETPVGERAPT 232
            LD+    PP   P        P   P PL PPT  KP + P+       V +PV    P 
Sbjct: 2399 LDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKL---TVASPVTTATPL 2455

Query: 233  PVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLK---VSWENPSPQEAPAAESAE 289
              + ++  +      +  P      +  PP    P  +    V    P P + P A    
Sbjct: 2456 FDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPV 2515

Query: 290  PSQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDS 349
              Q P   T+   P +    P P    L+  +  ++        P+P T  +S +    S
Sbjct: 2516 IPQLP---TTTQKPTD--IHPKPTGLSLTSSMTLNLVTSADYKLPSP-TSPLSPHSNKSS 2569

Query: 350  PEPAK-----------PSQAEGTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEG 398
            P  +K           PS+    PGT P D++ S A+  W       P  S   DL+   
Sbjct: 2570 PRFSKSLTETYVVITLPSE----PGT-PTDSSASQAITSW-------PLGSPSKDLVSVE 2617

Query: 399  PRHPLQPRERLYRAQLEVKVASEQTEKLLNKVLGSEPAPVSAETLLSQAVEQLRQ 453
            P   + P        +E+ ++SEQT  +   +      PV+A +    A   + Q
Sbjct: 2618 PVFSVVPPV----TAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAAPTSVTQ 2668



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 46/189 (24%), Positives = 72/189 (38%), Gaps = 31/189 (16%)

Query: 105  EEKE--SWIKALNEGINRGKNKAFDEVKVDKSCALEHVTRDRVRGGQRRRPPTRVHLKEV 162
            EEKE  + ++ L  GINR K     E +  +   L+ V  DR          TR    E 
Sbjct: 3790 EEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPTRIE- 3848

Query: 163  ASAASDGLLRLDLDVPDSGPPVFAPSNHVSEAQP--RETPRPLMPPTKPFLAPETTSPGD 220
               +  G+ R          P  AP    S+  P   +T   L+PPT P+   + +SP  
Sbjct: 3849 ---SQHGIER----------PRTAPQTEFSQFIPPQTQTESQLVPPTSPYTQYQYSSPAL 3895

Query: 221  RVETPVGERAPTPVSASS----EVSPESQED--------SETPAEEDSGSEQPPNSVLPD 268
              + P      +     +    +VSP   +         S TP  + + + Q P+  LP 
Sbjct: 3896 PTQAPTSYTQQSHFEQQTLYHQQVSPYQTQPTFQAVATMSFTPQVQPTPTPQ-PSYQLPS 3954

Query: 269  KLKVSWENP 277
            ++ V  + P
Sbjct: 3955 QMMVIQQKP 3963



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 35/144 (24%), Positives = 49/144 (34%), Gaps = 25/144 (17%)

Query: 239  EVSPESQEDSETPAEEDSGS------EQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQ 292
            EV    ++  E  AE    S      + PP+SV+   +K   E  S     + E+    +
Sbjct: 2315 EVLEAYRDKKELEAERTKSSLSETVFDHPPSSVIALPMK---EQLSTTYFTSGETFG-QE 2370

Query: 293  APCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEP 352
             P S+    +P     P  P P   S  L     ++ A  PP P             P P
Sbjct: 2371 KPASQLPSGSPSVSSLPAKPRPFFRSSSL-----DISAQPPPPP----------PPPPPP 2415

Query: 353  AKPSQAEGTPGTPPKDATTSTALP 376
              P      P  PP  +   T LP
Sbjct: 2416 PPPPPPPPPPPLPPPTSPKPTILP 2439


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 55/230 (23%), Positives = 86/230 (37%), Gaps = 32/230 (13%)

Query: 181 GPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPT--PVSASS 238
           GP   A    V +  P + P P  PPT+    P+  +    +++P     PT  PV    
Sbjct: 387 GPKALAQPPGVGKT-PAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPG 445

Query: 239 EVS-PESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSE 297
               P  Q      + + +G  +PP+ +           P P + P  +   P++ P  +
Sbjct: 446 PGKIPAQQAGPGKTSAQQTGPTKPPSQL-----------PGPAKPPPQQPG-PAKPPPQQ 493

Query: 298 TSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPA--PGTVQVSVNGMDDSPEPAKP 355
              A P       T PP       K S  +  ++ PP+  PG+ + S       P PAKP
Sbjct: 494 PGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSA----QQPSPAKP 549

Query: 356 SQAE----------GTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLL 395
           S  +          G P  PP  + ++   P   LP    P C++   LL
Sbjct: 550 SAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLL 599



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 59/219 (26%), Positives = 79/219 (36%), Gaps = 30/219 (13%)

Query: 180 SGPPVFAPSNHVSEAQP----RETPRPLMPPTKP--FLAPETTSPGDRVETPV---GERA 230
           S PP+  P+     AQ     +  P P  PP +P     P    PG  V+ PV   G   
Sbjct: 302 SKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGT-VKPPVQPPGTTK 360

Query: 231 PTPVSASSEVSPESQEDSETPAEEDSGSE---QPPNSVLPDKLKVSWENPSPQEAPAAES 287
           P          P  Q  SE P+ E  G +   QPP        K   + P P + P  + 
Sbjct: 361 PPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVG-----KTPAQQPGPAKPPTQQV 415

Query: 288 AEP---SQAPCSETSEAAPREGGKPPTP-----PPKILSEKLKASMGEMQASGPPAPGT- 338
             P   +Q P  ++   AP   G   TP     P KI +++        Q +GP  P + 
Sbjct: 416 GTPKPLAQQPGLQSPAKAP---GPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQ 472

Query: 339 VQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPP 377
           +          P PAKP   +     PP     ST  PP
Sbjct: 473 LPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPP 511



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 55/224 (24%), Positives = 78/224 (34%), Gaps = 42/224 (18%)

Query: 193  EAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSET-- 250
            +AQ + +P+P     KP      T PG R     G+  PTP     + SP+ QE S    
Sbjct: 857  KAQTKMSPKP---DAKPMPKGSPTPPGPR--PTAGQTVPTP-----QQSPKPQEQSRRFS 906

Query: 251  ---PAEEDSGSEQP--PNSVLPDKL----------------KVSWENPSPQEAPAA---E 286
                +  D+   QP  P   +  KL                      P  Q  P A   +
Sbjct: 907  LNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQ 966

Query: 287  SAEPSQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGM 346
            +  PSQ P   TS+  P+  G+ P  P K +  K +      +   P A     V     
Sbjct: 967  APAPSQPP---TSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTET 1023

Query: 347  DDSPEPAKPSQAEGTPGTPPKDATTSTALPPWDLPPQFHPRCSS 390
            +  P P K S+   +    P+ A   T L     P    P C +
Sbjct: 1024 EKKPPPIKDSK---SLTAEPQKAVLPTKLEKSPKPESTCPLCKT 1064



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 64/273 (23%), Positives = 99/273 (36%), Gaps = 28/273 (10%)

Query: 149 QRRRPPT--RVHLKEVASAASDGLLRLDLDVPDSGPPVFAPSNHVSEAQPRETPRPLMPP 206
           Q  RPP   R     ++ + +    R +  +P   P   +     S    +E  +  M P
Sbjct: 95  QSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMP 154

Query: 207 TKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVL 266
              FL+         V + V +  P  + + SE S E     +   +++ G    P  ++
Sbjct: 155 G--FLSEVNALSA--VSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGK---PEGII 207

Query: 267 PDKLKVSWENPSP-QEAPAAESAEPSQAPCSETSE------AAPREGGKP---PTPPPKI 316
              L+     P P Q+ P  +  +    P S +S+      + P   GKP   PT  P+ 
Sbjct: 208 KPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQT 267

Query: 317 LSEKLKASMGEMQASGPPAPGTVQVSVNGMDDS-PEPAKPSQAEGTPGTPPKDATTSTAL 375
              KL     +  AS P       V    +  S P P+KP   + TPG PP         
Sbjct: 268 DHAKLPL---QRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKS 324

Query: 376 PPWDLPPQFHPRCSSLGDLLGEGP---RHPLQP 405
            P    P   P  S L   L + P   + P+QP
Sbjct: 325 QPGPAKPPAQP--SGLTKPLAQQPGTVKPPVQP 355



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 56/238 (23%), Positives = 83/238 (34%), Gaps = 20/238 (8%)

Query: 178 PDSGPP-VFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGE---RAPTP 233
           P   PP V  P+ H S +   + P      +KP    E + P ++ + PV +   + P  
Sbjct: 700 PKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKM 759

Query: 234 VSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQA 293
           V  ++++   S   ++          Q      P  LK     PS    P  E   P   
Sbjct: 760 VKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP-PLKTDSAKPSQSFPPTGEKVSPFD- 817

Query: 294 PCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPA 353
                S+A PR     P    KI+S    +S  + Q    P     +        SP+P 
Sbjct: 818 -----SKAIPR-----PASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPD 867

Query: 354 KPSQAEGTPGTP-PKDATTSTALPPWDLP-PQFHPRCSS--LGDLLGEGPRHPLQPRE 407
                +G+P  P P+     T   P   P PQ   R  S  LG +       P  P+E
Sbjct: 868 AKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQE 925



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 66/305 (21%), Positives = 116/305 (38%), Gaps = 58/305 (19%)

Query: 211 LAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKL 270
           LAP  +SP  +++T        PV+ +S VS  S +  +T  ++D+  +Q  +       
Sbjct: 650 LAPVPSSPQPKLKT-------APVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKA----- 697

Query: 271 KVSWENPSPQEA-PAAESAEPSQAPCSETSEAAPREGGKPPTPP--PKILSEKLKASMGE 327
                 P P++  P  +      +P ++  +    +    P PP  P + SE+ KA + +
Sbjct: 698 ------PEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVAD 751

Query: 328 MQASGPP--APGTVQVSVNGMDDSPE-PAKPSQAEGTPGTPPKDATTSTALPPWDLPPQ- 383
            +   P    P T  VS +     P+ P+   Q++    T P    T +A P    PP  
Sbjct: 752 DKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP-PLKTDSAKPSQSFPPTG 810

Query: 384 ---------------------FHPRCSSLGDLLGEGPRHPLQPRERLYRAQLEVKVASEQ 422
                                 HP  SS  +  G+    P+Q +E   +AQ   K++ + 
Sbjct: 811 EKVSPFDSKAIPRPASDSKIISHPGPSS--ESKGQKQVDPVQKKEEPKKAQ--TKMSPKP 866

Query: 423 TEKLLNKVLGSEPAPVSAETLLSQAVEQLRQATQVLQEMR----DLGELSQEAPGLREKR 478
             K + K     P P        Q V   +Q+ +  ++ R    +LG ++          
Sbjct: 867 DAKPMPK---GSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTP 923

Query: 479 KELVT 483
           +E VT
Sbjct: 924 QETVT 928



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 68/295 (23%), Positives = 105/295 (35%), Gaps = 41/295 (13%)

Query: 175  LDVPDSGPPVFAPSNHVSEAQPRETPRPLMPPT--KPFLAPETTSPGDRVETPVGERAPT 232
            LD+    PP   P        P   P PL PPT  KP + P+       V +PV    P 
Sbjct: 2399 LDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKL---TVASPVTTATPL 2455

Query: 233  PVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLK---VSWENPSPQEAPAAESAE 289
              + ++  +      +  P      +  PP    P  +    V    P P + P A    
Sbjct: 2456 FDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPV 2515

Query: 290  PSQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDS 349
              Q P   T+   P +    P P    L+  +  ++        P+P T  +S +    S
Sbjct: 2516 IPQLP---TTTQKPTD--IHPKPTGLSLTSSMTLNLVTSADYKLPSP-TSPLSPHSNKSS 2569

Query: 350  PEPAK-----------PSQAEGTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEG 398
            P  +K           PS+    PGT P D++ S A+  W       P  S   DL+   
Sbjct: 2570 PRFSKSLTETYVVITLPSE----PGT-PTDSSASQAITSW-------PLGSPSKDLVSVE 2617

Query: 399  PRHPLQPRERLYRAQLEVKVASEQTEKLLNKVLGSEPAPVSAETLLSQAVEQLRQ 453
            P   + P        +E+ ++SEQT  +   +      PV+A +    A   + Q
Sbjct: 2618 PVFSVVPPV----TAVEIPISSEQTFYISGALQTFSATPVTAPSSFQAAPTSVTQ 2668



 Score = 31.2 bits (69), Expect = 2.2
 Identities = 46/189 (24%), Positives = 72/189 (38%), Gaps = 31/189 (16%)

Query: 105  EEKE--SWIKALNEGINRGKNKAFDEVKVDKSCALEHVTRDRVRGGQRRRPPTRVHLKEV 162
            EEKE  + ++ L  GINR K     E +  +   L+ V  DR          TR    E 
Sbjct: 3790 EEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPTRIE- 3848

Query: 163  ASAASDGLLRLDLDVPDSGPPVFAPSNHVSEAQP--RETPRPLMPPTKPFLAPETTSPGD 220
               +  G+ R          P  AP    S+  P   +T   L+PPT P+   + +SP  
Sbjct: 3849 ---SQHGIER----------PRTAPQTEFSQFIPPQTQTESQLVPPTSPYTQYQYSSPAL 3895

Query: 221  RVETPVGERAPTPVSASS----EVSPESQED--------SETPAEEDSGSEQPPNSVLPD 268
              + P      +     +    +VSP   +         S TP  + + + Q P+  LP 
Sbjct: 3896 PTQAPTSYTQQSHFEQQTLYHQQVSPYQTQPTFQAVATMSFTPQVQPTPTPQ-PSYQLPS 3954

Query: 269  KLKVSWENP 277
            ++ V  + P
Sbjct: 3955 QMMVIQQKP 3963



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 35/144 (24%), Positives = 49/144 (34%), Gaps = 25/144 (17%)

Query: 239  EVSPESQEDSETPAEEDSGS------EQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQ 292
            EV    ++  E  AE    S      + PP+SV+   +K   E  S     + E+    +
Sbjct: 2315 EVLEAYRDKKELEAERTKSSLSETVFDHPPSSVIALPMK---EQLSTTYFTSGETFG-QE 2370

Query: 293  APCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEP 352
             P S+    +P     P  P P   S  L     ++ A  PP P             P P
Sbjct: 2371 KPASQLPSGSPSVSSLPAKPRPFFRSSSL-----DISAQPPPPP----------PPPPPP 2415

Query: 353  AKPSQAEGTPGTPPKDATTSTALP 376
              P      P  PP  +   T LP
Sbjct: 2416 PPPPPPPPPPPLPPPTSPKPTILP 2439


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 49/214 (22%), Positives = 75/214 (35%), Gaps = 43/214 (20%)

Query: 192 SEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVS--------PE 243
           S+  PRE P P  P   P + P  T+P  ++  P   + P  +S  S  S        P 
Sbjct: 355 SQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPA 414

Query: 244 SQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAE-----PSQAPCSET 298
            +  S         +  PP  ++P    +     SP + P    ++     P+  P +  
Sbjct: 415 LKPLSSLSTHHPPSAHPPPLQLMPQSQPLP---SSPAQPPGLTQSQNLPPPPASHPPTGL 471

Query: 299 SEAAPR---------EGGKPPTPPPKILSEKLKASMGEMQASGPPAPG------------ 337
            + AP+          GG PP  PP   S     + G   ++ PP  G            
Sbjct: 472 HQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPA-GPGTSAQPPCSGAAASGGSIAGGS 530

Query: 338 -----TVQVSVNGMDDSPEPAKPSQAEGTPGTPP 366
                TVQ+    +DD+ EP  P     +P   P
Sbjct: 531 SCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEP 564



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/172 (23%), Positives = 62/172 (36%), Gaps = 32/172 (18%)

Query: 225 PVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPA 284
           P   +APT V+ +   +P       TP    S +  PP             +P+  +AP 
Sbjct: 184 PPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQG-----------SPTASQAPN 232

Query: 285 AESAEPSQAPCSETSEAAPREGGKPPTP-PPKILS-----EKLKASMGE----------M 328
              A  +  P +   +A      +PP+P PP   S     + L  S G+          +
Sbjct: 233 QPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPL 292

Query: 329 QASGPPAPGTVQVSVNGMDDSPE-----PAKPSQAEGTPGTPPKDATTSTAL 375
              GPP P ++Q         P      P + SQ +   GT P  A   T+L
Sbjct: 293 HGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSL 344



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 48/189 (25%), Positives = 66/189 (34%), Gaps = 28/189 (14%)

Query: 234 VSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQ--EAPAAESAEPS 291
           +S  +  S    E S++ +  D GS  P + +  D    S   PSPQ  E+ +  SA+  
Sbjct: 120 ISRPNSPSEGEGESSDSRSVNDEGSSDPKD-IDQDNRSTSPSIPSPQDNESDSDSSAQQQ 178

Query: 292 ---------QAPCSETSEAAPREGGKP----PTPPPKILSEKLKASMGEMQASGPPAPGT 338
                    QAP   T   +    G P    P P P   +   + S    QA   P   T
Sbjct: 179 MLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPT 238

Query: 339 VQVSVNGMDDSP--EPAKPSQAEGTPGT---PPKDATTSTALPPWDLPPQFHPRCSSLGD 393
             V    +  +P   P +P      P     PP    T +A  P   P    P       
Sbjct: 239 APVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQP-SAPSHAQP------P 291

Query: 394 LLGEGPRHP 402
           L G+GP  P
Sbjct: 292 LHGQGPPGP 300



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 25/104 (24%), Positives = 40/104 (38%), Gaps = 5/104 (4%)

Query: 200 PRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVS-----PESQEDSETPAEE 254
           P P+ PPT P  +     PG   + P    A +  S +   S      + +E++   AEE
Sbjct: 490 PPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEE 549

Query: 255 DSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSET 298
                 PP S  P+   V   + + Q A   +  +     C+ T
Sbjct: 550 PESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCART 593


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 49/214 (22%), Positives = 75/214 (35%), Gaps = 43/214 (20%)

Query: 192  SEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVS--------PE 243
            S+  PRE P P  P   P + P  T+P  ++  P   + P  +S  S  S        P 
Sbjct: 909  SQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPA 968

Query: 244  SQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAE-----PSQAPCSET 298
             +  S         +  PP  ++P    +     SP + P    ++     P+  P +  
Sbjct: 969  LKPLSSLSTHHPPSAHPPPLQLMPQSQPLP---SSPAQPPGLTQSQNLPPPPASHPPTGL 1025

Query: 299  SEAAPR---------EGGKPPTPPPKILSEKLKASMGEMQASGPPAPG------------ 337
             + AP+          GG PP  PP   S     + G   ++ PP  G            
Sbjct: 1026 HQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPA-GPGTSAQPPCSGAAASGGSIAGGS 1084

Query: 338  -----TVQVSVNGMDDSPEPAKPSQAEGTPGTPP 366
                 TVQ+    +DD+ EP  P     +P   P
Sbjct: 1085 SCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEP 1118



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/172 (23%), Positives = 62/172 (36%), Gaps = 32/172 (18%)

Query: 225 PVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPA 284
           P   +APT V+ +   +P       TP    S +  PP             +P+  +AP 
Sbjct: 738 PPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQG-----------SPTASQAPN 786

Query: 285 AESAEPSQAPCSETSEAAPREGGKPPTP-PPKILS-----EKLKASMGE----------M 328
              A  +  P +   +A      +PP+P PP   S     + L  S G+          +
Sbjct: 787 QPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPL 846

Query: 329 QASGPPAPGTVQVSVNGMDDSPE-----PAKPSQAEGTPGTPPKDATTSTAL 375
              GPP P ++Q         P      P + SQ +   GT P  A   T+L
Sbjct: 847 HGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSL 898



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 48/189 (25%), Positives = 66/189 (34%), Gaps = 28/189 (14%)

Query: 234 VSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQ--EAPAAESAEPS 291
           +S  +  S    E S++ +  D GS  P + +  D    S   PSPQ  E+ +  SA+  
Sbjct: 674 ISRPNSPSEGEGESSDSRSVNDEGSSDPKD-IDQDNRSTSPSIPSPQDNESDSDSSAQQQ 732

Query: 292 ---------QAPCSETSEAAPREGGKP----PTPPPKILSEKLKASMGEMQASGPPAPGT 338
                    QAP   T   +    G P    P P P   +   + S    QA   P   T
Sbjct: 733 MLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPT 792

Query: 339 VQVSVNGMDDSP--EPAKPSQAEGTPGT---PPKDATTSTALPPWDLPPQFHPRCSSLGD 393
             V    +  +P   P +P      P     PP    T +A  P   P    P       
Sbjct: 793 APVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQP-SAPSHAQP------P 845

Query: 394 LLGEGPRHP 402
           L G+GP  P
Sbjct: 846 LHGQGPPGP 854



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 25/104 (24%), Positives = 40/104 (38%), Gaps = 5/104 (4%)

Query: 200  PRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVS-----PESQEDSETPAEE 254
            P P+ PPT P  +     PG   + P    A +  S +   S      + +E++   AEE
Sbjct: 1044 PPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEE 1103

Query: 255  DSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSET 298
                  PP S  P+   V   + + Q A   +  +     C+ T
Sbjct: 1104 PESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCART 1147


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 49/214 (22%), Positives = 75/214 (35%), Gaps = 43/214 (20%)

Query: 192  SEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVS--------PE 243
            S+  PRE P P  P   P + P  T+P  ++  P   + P  +S  S  S        P 
Sbjct: 909  SQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPA 968

Query: 244  SQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAE-----PSQAPCSET 298
             +  S         +  PP  ++P    +     SP + P    ++     P+  P +  
Sbjct: 969  LKPLSSLSTHHPPSAHPPPLQLMPQSQPLP---SSPAQPPGLTQSQNLPPPPASHPPTGL 1025

Query: 299  SEAAPR---------EGGKPPTPPPKILSEKLKASMGEMQASGPPAPG------------ 337
             + AP+          GG PP  PP   S     + G   ++ PP  G            
Sbjct: 1026 HQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPA-GPGTSAQPPCSGAAASGGSIAGGS 1084

Query: 338  -----TVQVSVNGMDDSPEPAKPSQAEGTPGTPP 366
                 TVQ+    +DD+ EP  P     +P   P
Sbjct: 1085 SCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEP 1118



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/172 (23%), Positives = 62/172 (36%), Gaps = 32/172 (18%)

Query: 225 PVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPA 284
           P   +APT V+ +   +P       TP    S +  PP             +P+  +AP 
Sbjct: 738 PPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQG-----------SPTASQAPN 786

Query: 285 AESAEPSQAPCSETSEAAPREGGKPPTP-PPKILS-----EKLKASMGE----------M 328
              A  +  P +   +A      +PP+P PP   S     + L  S G+          +
Sbjct: 787 QPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPL 846

Query: 329 QASGPPAPGTVQVSVNGMDDSPE-----PAKPSQAEGTPGTPPKDATTSTAL 375
              GPP P ++Q         P      P + SQ +   GT P  A   T+L
Sbjct: 847 HGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSL 898



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 48/189 (25%), Positives = 66/189 (34%), Gaps = 28/189 (14%)

Query: 234 VSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQ--EAPAAESAEPS 291
           +S  +  S    E S++ +  D GS  P + +  D    S   PSPQ  E+ +  SA+  
Sbjct: 674 ISRPNSPSEGEGESSDSRSVNDEGSSDPKD-IDQDNRSTSPSIPSPQDNESDSDSSAQQQ 732

Query: 292 ---------QAPCSETSEAAPREGGKP----PTPPPKILSEKLKASMGEMQASGPPAPGT 338
                    QAP   T   +    G P    P P P   +   + S    QA   P   T
Sbjct: 733 MLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPT 792

Query: 339 VQVSVNGMDDSP--EPAKPSQAEGTPGT---PPKDATTSTALPPWDLPPQFHPRCSSLGD 393
             V    +  +P   P +P      P     PP    T +A  P   P    P       
Sbjct: 793 APVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQP-SAPSHAQP------P 845

Query: 394 LLGEGPRHP 402
           L G+GP  P
Sbjct: 846 LHGQGPPGP 854



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 25/104 (24%), Positives = 40/104 (38%), Gaps = 5/104 (4%)

Query: 200  PRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVS-----PESQEDSETPAEE 254
            P P+ PPT P  +     PG   + P    A +  S +   S      + +E++   AEE
Sbjct: 1044 PPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEE 1103

Query: 255  DSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSET 298
                  PP S  P+   V   + + Q A   +  +     C+ T
Sbjct: 1104 PESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCART 1147


>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
           tract binding protein associated) [Homo sapiens]
          Length = 707

 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 57/198 (28%), Positives = 70/198 (35%), Gaps = 35/198 (17%)

Query: 182 PPVFAPSNHVSEAQPR-ETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEV 240
           PP+  P  H  + QP  + P P  PP  P   P    P  + + P     P P  +S  V
Sbjct: 58  PPIPPPPPHQQQQQPPPQQPPPQQPP--PHQPPPHPQPHQQQQPP-----PPPQDSSKPV 110

Query: 241 -----SPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPC 295
                 P     S  PA   +    PP S  P     S   P+P   PA  SA P   P 
Sbjct: 111 VAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPG---SGPGPTPTPPPAVTSAPPGAPPP 167

Query: 296 SETSEAAP----REGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPE 351
           +  S   P    + GG PP PP  +         G  Q  GP  P   ++        P 
Sbjct: 168 TPPSSGVPTTPPQAGG-PPPPPAAVPG----PGPGPKQGPGPGGPKGGKM--------PG 214

Query: 352 PAKPSQAEG--TPGTPPK 367
             KP    G  TPG  PK
Sbjct: 215 GPKPGGGPGLSTPGGHPK 232



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 35/145 (24%), Positives = 48/145 (33%), Gaps = 27/145 (18%)

Query: 242 PESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQA----PCSE 297
           P  Q+  + P ++    + PP+   P       + P P   P  +S++P  A    P   
Sbjct: 64  PPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPP---PPQDSSKPVVAQGPGPAPG 120

Query: 298 TSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQ 357
              A P     PP  PP         + G    SGP           G   +P PA  S 
Sbjct: 121 VGSAPPASSSAPPATPP---------TSGAPPGSGP-----------GPTPTPPPAVTSA 160

Query: 358 AEGTPGTPPKDATTSTALPPWDLPP 382
             G P   P  +   T  P    PP
Sbjct: 161 PPGAPPPTPPSSGVPTTPPQAGGPP 185


>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
          Length = 1612

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 66/263 (25%), Positives = 87/263 (33%), Gaps = 32/263 (12%)

Query: 194  AQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAE 253
            AQP E  RP  PP +P   P   +P  R   P G R+P P     E        S   A 
Sbjct: 1139 AQPLEPKRP--PPPRPVAPPTRPAPPQRPPPPSGARSPAP--TRKEFGGIGAPPSPGVAR 1194

Query: 254  EDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPP 313
             +  + + P +   D +  S   PSPQ    A  A P  A  S      P   G    P 
Sbjct: 1195 REMEAPKSPGTTRKDNIGRS--QPSPQ----AGLAGPGPAGYSTARPTIPPRAGVISAP- 1247

Query: 314  PKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDA---- 369
                    +AS G +    P +      +  G    PEP KP  A     + P  A    
Sbjct: 1248 ----QSHARASAGRLT---PESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQ 1300

Query: 370  ----------TTSTALPPWDLPPQFHPRCSSLGDLLGEGPRHPLQPRERLYRAQLEVKVA 419
                        S   P  + PPQ  PR  S   L  E    P      +   + E  + 
Sbjct: 1301 EPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQVKTNGISDGKRESPLK 1360

Query: 420  SEQTEKLLNKVLGSEPAPVSAET 442
             +  E L   +L    A +S +T
Sbjct: 1361 IDPFEDLSFNLLAVSKAQLSVQT 1383



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 32/139 (23%), Positives = 50/139 (35%), Gaps = 3/139 (2%)

Query: 233  PVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQ 292
            P S+S   +  S     +P +  + SE P  S+     +     P P  A ++       
Sbjct: 1071 PSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPA 1130

Query: 293  APCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEP 352
             P  +   A P E  +PP P P     +          SG  +P   +    G+   P P
Sbjct: 1131 TPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGGIGAPPSP 1190

Query: 353  A---KPSQAEGTPGTPPKD 368
                +  +A  +PGT  KD
Sbjct: 1191 GVARREMEAPKSPGTTRKD 1209



 Score = 32.7 bits (73), Expect = 0.77
 Identities = 35/149 (23%), Positives = 56/149 (37%), Gaps = 16/149 (10%)

Query: 237  SSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEA-PAAESAEPSQAPC 295
            SS  S    ED+E  A+ D   +    S   ++L      PS       + S+ P  +PC
Sbjct: 1031 SSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPC 1090

Query: 296  SETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSP--EPA 353
               + +   EG  P  P        ++ S    +  GPP+  +  +        P  +PA
Sbjct: 1091 QSPTIS---EGPVPSLP--------IRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDPA 1139

Query: 354  KPSQAEGTPGTPPKDATTSTALPPWDLPP 382
            +P + +  P  PP+     T   P   PP
Sbjct: 1140 QPLEPKRPP--PPRPVAPPTRPAPPQRPP 1166


>gi|50345997 E1A binding protein p300 [Homo sapiens]
          Length = 2414

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 62/279 (22%), Positives = 104/279 (37%), Gaps = 34/279 (12%)

Query: 183  PVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTS------PGDRVETPVGERAPTPVSA 236
            P+  P +  S     + P+P +    P   P  T       P    + P     P PV  
Sbjct: 806  PIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPT 865

Query: 237  SSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCS 296
               + P  Q  +  P    + +  PP + LP +++     PS   AP+A+  +P Q P S
Sbjct: 866  PPAMPPGPQSQALHPPPRQTPT--PPTTQLPQQVQ-----PSLPAAPSAD--QPQQQPRS 916

Query: 297  ETSEAAPREGGKPPTPPPKILSEKLKASMG-EMQASGPPAPGTVQVSVNGMDDSPEPAKP 355
            + S AA       P  PP+  +   + ++  E Q S PP+  + +V+   + +     +P
Sbjct: 917  QQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEK----QP 972

Query: 356  SQAEGTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGPRHPLQPRERLYRAQLE 415
            SQ          D        P D+       C               +  ER    + E
Sbjct: 973  SQEVKMEAKMEVDQPEPADTQPEDISESKVEDCK----------MESTETEERSTELKTE 1022

Query: 416  VKVASEQTEKLLNKVLGSEPAPVSAETLLSQAVEQLRQA 454
            +K   E+ ++       S PAP  ++  + +  E+LRQA
Sbjct: 1023 IK---EEEDQPSTSATQSSPAPGQSKKKIFKP-EELRQA 1057



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 69/336 (20%), Positives = 114/336 (33%), Gaps = 56/336 (16%)

Query: 149  QRRRPPTRVHLKEVASAASDGLLRLDLDVPDSGP-----PVFAPSNHVSEAQPRETPRPL 203
            Q R    ++  + +AS    G++     +P   P     P           QP   P+P 
Sbjct: 1819 QHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPT 1878

Query: 204  MPPTKPFLAPETTSPG--------DRVETPVGERA-----PTPVSASSEVSPESQEDSET 250
             P + P   P T + G         +V  P   +      P P  A+ E++ + Q  +ET
Sbjct: 1879 PPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAET 1938

Query: 251  PAEEDSGS--EQPPNSVLPDKLKVS--WENPSPQEAPAAESAEPSQAPCSETSEAAPREG 306
              +       ++P    +P    ++    NP P     +   EP   P     +    +G
Sbjct: 1939 QRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQG 1998

Query: 307  GKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPP 366
            G    P P+ L             SG P P  + V+ +G    P    P    G  G  P
Sbjct: 1999 G---LPQPQQLQ------------SGMPRPAMMSVAQHG---QPLNMAPQPGLGQVGISP 2040

Query: 367  KDATTSTALPPWDLPPQFHPRCSSLGDLLG--EGPRHPLQPRERLYRAQLEVKVASEQTE 424
                    L P  +  Q      +L +LL     P  PLQ ++ L       ++ +   +
Sbjct: 2041 --------LKPGTVSQQ------ALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIK 2086

Query: 425  KLLNKVLGSEPAPVSAETLLSQAVEQLRQATQVLQE 460
            +   K   S P P+  +  + Q    L+  T   Q+
Sbjct: 2087 QRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQ 2122


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.128    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,157,850
Number of Sequences: 37866
Number of extensions: 1576018
Number of successful extensions: 16098
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 233
Number of HSP's successfully gapped in prelim test: 1587
Number of HSP's that attempted gapping in prelim test: 9289
Number of HSP's gapped (non-prelim): 5752
length of query: 490
length of database: 18,247,518
effective HSP length: 106
effective length of query: 384
effective length of database: 14,233,722
effective search space: 5465749248
effective search space used: 5465749248
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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