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Search of human proteins with 33188459
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33188459 B-Raf [Homo sapiens]
(766 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33188459 B-Raf [Homo sapiens] 1545 0.0
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 694 0.0
gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Hom... 679 0.0
gi|167621456 kinase suppressor of ras 2 [Homo sapiens] 203 6e-52
gi|75677325 kinase suppressor of ras [Homo sapiens] 194 3e-49
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 154 2e-37
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 148 2e-35
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 144 2e-34
gi|4503787 fyn-related kinase [Homo sapiens] 144 4e-34
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 143 5e-34
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 143 5e-34
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 142 9e-34
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 142 1e-33
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 142 1e-33
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 142 1e-33
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 142 1e-33
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 139 1e-32
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 137 3e-32
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 137 4e-32
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 136 6e-32
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 135 1e-31
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 135 1e-31
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 135 1e-31
gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo sapi... 134 2e-31
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 134 3e-31
gi|32528301 EPH receptor B4 precursor [Homo sapiens] 132 9e-31
gi|4758280 ephrin receptor EphA4 [Homo sapiens] 130 4e-30
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 130 5e-30
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap... 129 8e-30
gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sap... 129 8e-30
>gi|33188459 B-Raf [Homo sapiens]
Length = 766
Score = 1545 bits (4000), Expect = 0.0
Identities = 766/766 (100%), Positives = 766/766 (100%)
Query: 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH 60
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
Sbjct: 1 MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH 60
Query: 61 IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV 120
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
Sbjct: 61 IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV 120
Query: 121 TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS 180
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
Sbjct: 121 TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS 180
Query: 181 LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK 240
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
Sbjct: 181 LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK 240
Query: 241 TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI 300
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
Sbjct: 241 TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI 300
Query: 301 PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR 360
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
Sbjct: 301 PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR 360
Query: 361 DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP 420
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
Sbjct: 361 DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP 420
Query: 421 GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV 480
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
Sbjct: 421 GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV 480
Query: 481 AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH 540
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
Sbjct: 481 AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH 540
Query: 541 LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV 600
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
Sbjct: 541 LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV 600
Query: 601 KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN 660
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
Sbjct: 601 KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN 660
Query: 661 NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS 720
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
Sbjct: 661 NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS 720
Query: 721 LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 766
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
Sbjct: 721 LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH 766
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 694 bits (1791), Expect = 0.0
Identities = 379/668 (56%), Positives = 459/668 (68%), Gaps = 42/668 (6%)
Query: 101 ESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVF 160
+++ NG F D V SS + + +D + S +RVF
Sbjct: 9 KTISNGFGFK-------DAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVF 61
Query: 161 LPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRI---QDGEKKPIGWDTDISWL 217
LPNKQRTVV R G+++ D L KAL +RGL PECCAV+R+ G+K + W+TD + L
Sbjct: 62 LPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASL 121
Query: 218 TGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVP 277
GEEL V+ L++VPLTTHNF RKTF LAFCD C+K L GFRCQTCGYKFH+ CST+VP
Sbjct: 122 IGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVP 181
Query: 278 LMCVNYDQLD--LLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPS 335
MCV++ + LLF + +P AL S + S S P S
Sbjct: 182 TMCVDWSNIRQLLLFPNSTIGDSGVP---------ALPSLTMRRMRESVSRMP---VSSQ 229
Query: 336 PSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVH-INTIEPVN---IDDLIRDQGFRGD 391
S P F + QR RS+S PNVH ++T PV+ I+D IR +
Sbjct: 230 HRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHS---E 286
Query: 392 GGSTTGLSATPPASLPGSLTNVKALQKSPGP-QRERKSSSSSEDRNRMKTLGRRDSSDDW 450
S + LS++P P + K+P P QRER S ++++N+++ G+RDSS W
Sbjct: 287 SASPSALSSSPNNLSPTGWSQ----PKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYW 342
Query: 451 EIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRH 510
EI ++ + RIGSGSFGTVYKGKWHGDVAVK+L V PTP+Q QAF+NEV VLRKTRH
Sbjct: 343 EIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRH 402
Query: 511 VNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK 570
VNILLFMGY TK LAIVTQWCEGSSLY HLH+ ETKF+M +LIDIARQTAQGMDYLHAK
Sbjct: 403 VNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAK 462
Query: 571 SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDK 630
+IIHRD+KSNNIFLHE LTVKIGDFGLATVKSRWSGS Q EQ +GS+LWMAPEVIRMQD
Sbjct: 463 NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDN 522
Query: 631 NPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMK 690
NP+SFQSDVY++GIVLYELMTG+LPYS+INNRDQIIFMVGRGY SPDLSK+ NCPKAMK
Sbjct: 523 NPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMK 582
Query: 691 RLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYAC-- 748
RL+A+C+KK ++ERPLFPQIL+SIELL SLPKI+RSASEPSL+RA TED + AC
Sbjct: 583 RLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAA-HTEDIN--ACTL 639
Query: 749 -ASPKTPI 755
SP+ P+
Sbjct: 640 TTSPRLPV 647
>gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Homo
sapiens]
Length = 606
Score = 679 bits (1752), Expect = 0.0
Identities = 359/616 (58%), Positives = 442/616 (71%), Gaps = 41/616 (6%)
Query: 147 SNPKSPQKPI--VRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGE 204
+N P + + V+V+LPNKQRTVV R G++V DSL KAL +RGL +CC VYR+ G
Sbjct: 9 ANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGR 68
Query: 205 KKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTC 264
K WDT I+ L GEEL VEVLE+VPLT HNFVRKTFF+LAFCDFC K LF GFRCQTC
Sbjct: 69 KTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTC 128
Query: 265 GYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASD 324
GYKFHQ CS++VP +CV+ F +H + L+ GS S+
Sbjct: 129 GYKFHQHCSSKVPTVCVDMSTNRQQF------YHSVQD---------LSGGSRQHEAPSN 173
Query: 325 SIGPQILTSPSPS--------KSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVH-INTIE 375
++LT PS + P P P N QR RS+S PNVH ++T
Sbjct: 174 RPLNELLTPQGPSPRTQHCDPEHFPFPAP--------ANAPLQRIRSTSTPNVHMVSTTA 225
Query: 376 PVNIDDL-IRDQGFRGDG-GSTTGLSATPPAS-LPGSLTNVKALQKSPGPQRERKSSSSS 432
P++ + + + Q F D GS G TP S P S+++ + S P +R+ S +
Sbjct: 226 PMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLA 285
Query: 433 EDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP 492
+D+ ++K LG RDS WE+P ++ + +RIG+GSFGTV++G+WHGDVAVK+L V+ PT
Sbjct: 286 DDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTA 345
Query: 493 QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIK 552
+Q QAFKNE+ VLRKTRHVNILLFMG+ T+P AI+TQWCEGSSLYHHLH+ +T+F+M++
Sbjct: 346 EQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQ 405
Query: 553 LIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQ 612
LID+ARQTAQGMDYLHAK+IIHRDLKSNNIFLHE LTVKIGDFGLATVK+RWSG+ EQ
Sbjct: 406 LIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQ 465
Query: 613 LSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRG 672
SGS+LWMA EVIRMQD NPYSFQSDVYA+G+VLYELMTG LPYS+I RDQIIFMVGRG
Sbjct: 466 PSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRG 525
Query: 673 YLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPS 732
YLSPDLSK+ SNCPKAM+RL+++CLK +R+ERPLFPQILA+IELL RSLPKI RSASEPS
Sbjct: 526 YLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPS 585
Query: 733 LNRAGFQTEDFSLYAC 748
L+R T+ L AC
Sbjct: 586 LHR----TQADELPAC 597
>gi|167621456 kinase suppressor of ras 2 [Homo sapiens]
Length = 921
Score = 203 bits (516), Expect = 6e-52
Identities = 158/555 (28%), Positives = 262/555 (47%), Gaps = 84/555 (15%)
Query: 235 HNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVP----LMCVNYDQLDL-- 288
H F K + + C C K + G +C+ C K H +C+ E P L+ D L
Sbjct: 384 HRFSTKYWMSQT-CTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVR 442
Query: 289 --------------------LFVSKFF--------EHHPIPQEEASLAETALTSGSSPSA 320
L +S+ +H P+P + S + + T+ S+PS+
Sbjct: 443 TESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSS 502
Query: 321 PASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNI- 379
PA P P + P P P P+ + R Q ++ + P H + I
Sbjct: 503 PAP----------PLPPSATP-PSPLHPSPQCTRQQ-----KNFNLPASHYYKYKQQFIF 546
Query: 380 DDLIRDQGFRGDGGSTTGLSATPPASLPGS-LTNVKALQKSPGPQRERKSSSSSEDRNRM 438
D++ T L G+ L ++ S + ++ S +D M
Sbjct: 547 PDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEM 606
Query: 439 -------KTLGRRDSS-----DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLN 486
++ R+ S +W+IP Q+ +G+ IG G FG VY G+WHG+VA+++++
Sbjct: 607 NLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLID 666
Query: 487 VTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHIIE 545
+ QL+AFK EV R+TRH N++LFMG + P LAI+T C+G +LY + +
Sbjct: 667 IERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAK 726
Query: 546 TKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS 605
++ K IA++ +GM YLHAK I+H+DLKS N+F +++ V I DFGL ++
Sbjct: 727 IVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVF-YDNGKVVITDFGLFSISGVLQ 785
Query: 606 GSHQFEQL---SGSILWMAPEVIRM------QDKNPYSFQSDVYAFGIVLYELMTGQLPY 656
+ ++L +G + +APE+IR +DK P+S SDV+A G + YEL + P+
Sbjct: 786 AGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPF 845
Query: 657 SNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIEL 716
+ II+ +G G + P+LS++ K + ++ C +++ERP F +++ +E
Sbjct: 846 KT-QPAEAIIWQMGTG-MKPNLSQI--GMGKEISDILLFCWAFEQEERPTFTKLMDMLE- 900
Query: 717 LARSLPKIHRSASEP 731
LPK +R S P
Sbjct: 901 ---KLPKRNRRLSHP 912
>gi|75677325 kinase suppressor of ras [Homo sapiens]
Length = 762
Score = 194 bits (493), Expect = 3e-49
Identities = 160/556 (28%), Positives = 257/556 (46%), Gaps = 70/556 (12%)
Query: 234 THNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSK 293
TH F K++ + C C+K + G +C+ C K H +C+ E P +++ L L ++
Sbjct: 210 THRFSTKSWLSQV-CHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTE 268
Query: 294 FFE---HHPIPQEEASLAET---ALTSGSSPSAP--ASDSIGPQILTSPSPSKSIPIPQP 345
++P+ + T ALT P A S P TS +PS P P
Sbjct: 269 SVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTS 328
Query: 346 FRP--ADEDHRNQFGQRDRSSSAPNVHI-----NTIEPVN----------IDDLIRDQGF 388
P A GQRD + P + I PV I + +++ F
Sbjct: 329 SNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAF 388
Query: 389 RGDGGSTTGLSATPPASLPGSL------TNVKALQKSPGPQRERKSSSSSEDRNRMKTL- 441
S +A P + G+ +V ++ + E S + +D + + L
Sbjct: 389 NI---SAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLP 445
Query: 442 ----------GRRDSS-----DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLN 486
R+ S +W+IP Q+ +G+ IG G +G V++G+WHG+VA+++L
Sbjct: 446 SSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLE 505
Query: 487 VTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHIIE 545
+ L+ FK EV R+TRH N++LFMG P LAI+T +C+G +L+ + +
Sbjct: 506 MDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPK 565
Query: 546 TKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS 605
T ++ K IA++ +GM YLHAK I+H+DLKS N+F +++ V I DFGL +
Sbjct: 566 TSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVF-YDNGKVVITDFGLFGISGVVR 624
Query: 606 GSHQFEQLSGSILW---MAPEVIRM------QDKNPYSFQSDVYAFGIVLYELMTGQLPY 656
+ QL S W +APE++R +D+ P+S +DVYAFG V YEL P
Sbjct: 625 EGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPL 684
Query: 657 SNINNRDQIIFMVGRGY-LSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
N + I+ +G G + L+ V + K + +++ C ERP F ++ +E
Sbjct: 685 KN-QAAEASIWQIGSGEGMKRVLTSV--SLGKEVSEILSACWAFDLQERPSFSLLMDMLE 741
Query: 716 LLARSLPKIHRSASEP 731
LPK++R S P
Sbjct: 742 ----KLPKLNRRLSHP 753
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 154 bits (390), Expect = 2e-37
Identities = 102/276 (36%), Positives = 151/276 (54%), Gaps = 22/276 (7%)
Query: 443 RRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKMLNVTAPTPQQLQAFKNE 501
++ D WE+P +I Q +GSG+ G V+ G++HG+ VAVK + T +
Sbjct: 111 KQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------D 161
Query: 502 VGVLRKTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQT 560
+ LRK +H NI+ F G T+ P I+ ++C LY L + L+D +
Sbjct: 162 IKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSL-LVDWSMGI 220
Query: 561 AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM 620
A GM+YLH IIHRDLKS N+ + D VKI DFG + S S F +G++ WM
Sbjct: 221 AGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSF---AGTVAWM 277
Query: 621 APEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSK 680
APEVIR P S + D+++FG+VL+EL+TG++PY ++++ II+ VG L
Sbjct: 278 APEVIR---NEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS-SAIIWGVGSNSLH---LP 330
Query: 681 VRSNCPKAMKRLMAECLKKKRDERPLFPQILASIEL 716
V S+CP K L+ +C K RP F QIL +++
Sbjct: 331 VPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDI 366
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 148 bits (373), Expect = 2e-35
Identities = 105/290 (36%), Positives = 152/290 (52%), Gaps = 27/290 (9%)
Query: 448 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD-VAVKMLNVTAPTPQQLQAFKNEVGVLR 506
D WE+P +I+ Q +GSG+ G V+ GK+ + VA+K + T ++ LR
Sbjct: 159 DTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNET---------DIKHLR 209
Query: 507 KTRHVNILLFMGYSTK-PQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMD 565
K +H NI+ F G T+ P I+ ++C LY L K L+D + A GM+
Sbjct: 210 KLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRA-GRKITPRLLVDWSTGIASGMN 268
Query: 566 YLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 625
YLH IIHRDLKS N+ + VKI DFG + S S F +G++ WMAPEVI
Sbjct: 269 YLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSF---AGTVAWMAPEVI 325
Query: 626 RMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNC 685
R P S + D+++FG+VL+EL+TG++PY ++++ II+ VG L V S C
Sbjct: 326 R---NEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS-SAIIWGVGSNSLH---LPVPSTC 378
Query: 686 PKAMKRLMAECLKKKRDERPLFPQIL-----ASIELLARSLPKIHRSASE 730
P K LM + + K RP F Q L AS ++LA +S +E
Sbjct: 379 PDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAE 428
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 144 bits (364), Expect = 2e-34
Identities = 94/277 (33%), Positives = 151/277 (54%), Gaps = 22/277 (7%)
Query: 446 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLNVTAPTPQQLQAFKNEVG 503
+ D WEIP + + +R+G+G FG V+ G W+G+ VA+K L +P+ +F E
Sbjct: 260 TKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPE---SFLEEAQ 316
Query: 504 VLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETK-FEMIKLIDIARQTAQ 562
+++K +H ++ ++ + IVT++ SL L E + ++ L+D+A Q A
Sbjct: 317 IMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAA 376
Query: 563 GMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGS---ILW 619
GM Y+ + IHRDL+S NI + L KI DFGLA R +++ G+ I W
Sbjct: 377 GMAYIERMNYIHRDLRSANILVGNGLICKIADFGLA----RLIEDNEYTARQGAKFPIKW 432
Query: 620 MAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDL 678
APE ++ +SDV++FGI+L EL+T G++PY +NNR +++ V RGY P
Sbjct: 433 TAPEAALY---GRFTIKSDVWSFGILLTELVTKGRVPYPGMNNR-EVLEQVERGYRMP-- 486
Query: 679 SKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
+CP ++ LM C KK +ERP F + + +E
Sbjct: 487 --CPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLE 521
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 144 bits (362), Expect = 4e-34
Identities = 93/278 (33%), Positives = 148/278 (53%), Gaps = 24/278 (8%)
Query: 448 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLNVTAPTPQQLQAFKNEVGVL 505
D WEI I + +R+GSG FG V++G W+ VAVK L + P F E ++
Sbjct: 225 DQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPND---FLREAQIM 281
Query: 506 RKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHL-HIIETKFEMIKLIDIARQTAQG 563
+ RH ++ L+ + + + I+T+ SL +L + +K + + +D+A Q A G
Sbjct: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
Query: 564 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV-----KSRWSGSHQFEQLSGSIL 618
M YL +++ IHRDL + N+ + E K+ DFGLA V + + H+ + +
Sbjct: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKL---PVK 398
Query: 619 WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPD 677
W APE IR N +S +SDV++FGI+LYE++T G++PYS + Q+I M+ + Y P
Sbjct: 399 WTAPEAIR---SNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGA-QVIQMLAQNYRLPQ 454
Query: 678 LSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
SNCP+ +M EC + ERP F + +E
Sbjct: 455 ----PSNCPQQFYNIMLECWNAEPKERPTFETLRWKLE 488
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 143 bits (361), Expect = 5e-34
Identities = 93/277 (33%), Positives = 150/277 (54%), Gaps = 22/277 (7%)
Query: 446 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLNVTAPTPQQLQAFKNEVG 503
+ D WEIP + + ++G G FG V+ G W+G VA+K L +P+ AF E
Sbjct: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPE---AFLQEAQ 315
Query: 504 VLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKF-EMIKLIDIARQTAQ 562
V++K RH ++ ++ + IVT++ SL L K+ + +L+D+A Q A
Sbjct: 316 VMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375
Query: 563 GMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGS---ILW 619
GM Y+ + +HRDL++ NI + E+L K+ DFGLA R +++ G+ I W
Sbjct: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA----RLIEDNEYTARQGAKFPIKW 431
Query: 620 MAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDL 678
APE ++ +SDV++FGI+L EL T G++PY + NR +++ V RGY P
Sbjct: 432 TAPEAALY---GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR-EVLDQVERGYRMP-- 485
Query: 679 SKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
CP+++ LM +C +K+ +ERP F + A +E
Sbjct: 486 --CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 143 bits (361), Expect = 5e-34
Identities = 93/277 (33%), Positives = 150/277 (54%), Gaps = 22/277 (7%)
Query: 446 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLNVTAPTPQQLQAFKNEVG 503
+ D WEIP + + ++G G FG V+ G W+G VA+K L +P+ AF E
Sbjct: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPE---AFLQEAQ 315
Query: 504 VLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKF-EMIKLIDIARQTAQ 562
V++K RH ++ ++ + IVT++ SL L K+ + +L+D+A Q A
Sbjct: 316 VMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375
Query: 563 GMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGS---ILW 619
GM Y+ + +HRDL++ NI + E+L K+ DFGLA R +++ G+ I W
Sbjct: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA----RLIEDNEYTARQGAKFPIKW 431
Query: 620 MAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDL 678
APE ++ +SDV++FGI+L EL T G++PY + NR +++ V RGY P
Sbjct: 432 TAPEAALY---GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR-EVLDQVERGYRMP-- 485
Query: 679 SKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
CP+++ LM +C +K+ +ERP F + A +E
Sbjct: 486 --CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 142 bits (359), Expect = 9e-34
Identities = 95/277 (34%), Positives = 149/277 (53%), Gaps = 22/277 (7%)
Query: 446 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLNVTAPTPQQLQAFKNEVG 503
+ D WEIP + + ++G G FG V+ G W+G VA+K L P +AF E
Sbjct: 266 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLK---PGTMMPEAFLQEAQ 322
Query: 504 VLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKF-EMIKLIDIARQTAQ 562
+++K RH ++ ++ + IVT++ SL L + K+ ++ +L+D+A Q A
Sbjct: 323 IMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIAD 382
Query: 563 GMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGS---ILW 619
GM Y+ + IHRDL++ NI + E+L KI DFGLA R +++ G+ I W
Sbjct: 383 GMAYIERMNYIHRDLRAANILVGENLVCKIADFGLA----RLIEDNEYTARQGAKFPIKW 438
Query: 620 MAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDL 678
APE ++ +SDV++FGI+ EL+T G++PY + NR +++ V RGY P
Sbjct: 439 TAPEAALY---GRFTIKSDVWSFGILQTELVTKGRVPYPGMVNR-EVLEQVERGYRMP-- 492
Query: 679 SKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
CP+++ LM C KK DERP F I + +E
Sbjct: 493 --CPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE 527
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 142 bits (358), Expect = 1e-33
Identities = 91/277 (32%), Positives = 158/277 (57%), Gaps = 26/277 (9%)
Query: 448 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLNVTAPTPQQLQAFKNEVGVL 505
D+WE+P + + +R+G+G FG V+ G ++G VAVK L + +P AF E ++
Sbjct: 236 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPD---AFLAEANLM 292
Query: 506 RKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIE-TKFEMIKLIDIARQTAQGM 564
++ +H ++ T+ + I+T++ E SL L K + KL+D+A Q A+GM
Sbjct: 293 KQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGM 352
Query: 565 DYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGS---ILWMA 621
++ ++ IHRDL++ NI + + L+ KI DFGLA R +++ G+ I W A
Sbjct: 353 AFIEERNYIHRDLRAANILVSDTLSCKIADFGLA----RLIEDNEYTAREGAKFPIKWTA 408
Query: 622 PEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGY--LSPDL 678
PE I + ++ +SDV++FGI+L E++T G++PY + N ++I + RGY + PD
Sbjct: 409 PEAI---NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTN-PEVIQNLERGYRMVRPD- 463
Query: 679 SKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
NCP+ + +LM C K++ ++RP F + + +E
Sbjct: 464 -----NCPEELYQLMRLCWKERPEDRPTFDYLRSVLE 495
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 142 bits (358), Expect = 1e-33
Identities = 91/277 (32%), Positives = 158/277 (57%), Gaps = 26/277 (9%)
Query: 448 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLNVTAPTPQQLQAFKNEVGVL 505
D+WE+P + + +R+G+G FG V+ G ++G VAVK L + +P AF E ++
Sbjct: 236 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPD---AFLAEANLM 292
Query: 506 RKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIE-TKFEMIKLIDIARQTAQGM 564
++ +H ++ T+ + I+T++ E SL L K + KL+D+A Q A+GM
Sbjct: 293 KQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGM 352
Query: 565 DYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGS---ILWMA 621
++ ++ IHRDL++ NI + + L+ KI DFGLA R +++ G+ I W A
Sbjct: 353 AFIEERNYIHRDLRAANILVSDTLSCKIADFGLA----RLIEDNEYTAREGAKFPIKWTA 408
Query: 622 PEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGY--LSPDL 678
PE I + ++ +SDV++FGI+L E++T G++PY + N ++I + RGY + PD
Sbjct: 409 PEAI---NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTN-PEVIQNLERGYRMVRPD- 463
Query: 679 SKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
NCP+ + +LM C K++ ++RP F + + +E
Sbjct: 464 -----NCPEELYQLMRLCWKERPEDRPTFDYLRSVLE 495
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 142 bits (358), Expect = 1e-33
Identities = 94/276 (34%), Positives = 150/276 (54%), Gaps = 23/276 (8%)
Query: 448 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLNVTAPTPQQLQAFKNEVGVL 505
D WEIP I + +R+G+G FG V+ G ++ VAVK L P +QAF E ++
Sbjct: 217 DAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLK---PGTMSVQAFLEEANLM 273
Query: 506 RKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIET-KFEMIKLIDIARQTAQG 563
+ +H ++ T+ + + I+T++ SL L E K + KLID + Q A+G
Sbjct: 274 KTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEG 333
Query: 564 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGS---ILWM 620
M Y+ K+ IHRDL++ N+ + E L KI DFGLA V +++ G+ I W
Sbjct: 334 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE----DNEYTAREGAKFPIKWT 389
Query: 621 APEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLS 679
APE I ++ +SDV++FGI+LYE++T G++PY N D ++ + +GY P +
Sbjct: 390 APEAINF---GCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNAD-VMTALSQGYRMPRV- 444
Query: 680 KVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
NCP + +M C K+K +ERP F + + ++
Sbjct: 445 ---ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLD 477
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 142 bits (358), Expect = 1e-33
Identities = 94/276 (34%), Positives = 150/276 (54%), Gaps = 23/276 (8%)
Query: 448 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLNVTAPTPQQLQAFKNEVGVL 505
D WEIP I + +R+G+G FG V+ G ++ VAVK L P +QAF E ++
Sbjct: 238 DAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLK---PGTMSVQAFLEEANLM 294
Query: 506 RKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIET-KFEMIKLIDIARQTAQG 563
+ +H ++ T+ + + I+T++ SL L E K + KLID + Q A+G
Sbjct: 295 KTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEG 354
Query: 564 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGS---ILWM 620
M Y+ K+ IHRDL++ N+ + E L KI DFGLA V +++ G+ I W
Sbjct: 355 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE----DNEYTAREGAKFPIKWT 410
Query: 621 APEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLS 679
APE I ++ +SDV++FGI+LYE++T G++PY N D ++ + +GY P +
Sbjct: 411 APEAINF---GCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNAD-VMTALSQGYRMPRV- 465
Query: 680 KVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
NCP + +M C K+K +ERP F + + ++
Sbjct: 466 ---ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLD 498
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 139 bits (350), Expect = 1e-32
Identities = 90/275 (32%), Positives = 148/275 (53%), Gaps = 22/275 (8%)
Query: 448 DDWEIPDGQITVGQRIGSGSFGTVYKGKW--HGDVAVKMLNVTAPTPQQLQAFKNEVGVL 505
D WEIP + + +++G+G FG V+ + H VAVK + P ++AF E V+
Sbjct: 253 DAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMK---PGSMSVEAFLAEANVM 309
Query: 506 RKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIE-TKFEMIKLIDIARQTAQGM 564
+ +H ++ TK + I+T++ SL L E +K + KLID + Q A+GM
Sbjct: 310 KTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGM 369
Query: 565 DYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGS---ILWMA 621
++ ++ IHRDL++ NI + L KI DFGLA V +++ G+ I W A
Sbjct: 370 AFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIE----DNEYTAREGAKFPIKWTA 425
Query: 622 PEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSK 680
PE I ++ +SDV++FGI+L E++T G++PY ++N ++I + RGY P
Sbjct: 426 PEAINF---GSFTIKSDVWSFGILLMEIVTYGRIPYPGMSN-PEVIRALERGYRMPR--- 478
Query: 681 VRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
NCP+ + +M C K + +ERP F I + ++
Sbjct: 479 -PENCPEELYNIMMRCWKNRPEERPTFEYIQSVLD 512
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 137 bits (346), Expect = 3e-32
Identities = 90/277 (32%), Positives = 148/277 (53%), Gaps = 22/277 (7%)
Query: 446 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLNVTAPTPQQLQAFKNEVG 503
+ D WE+ + + +++G G F V+ G W+G+ VA+K L +P+ +F E
Sbjct: 257 AKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPE---SFLEEAQ 313
Query: 504 VLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETK-FEMIKLIDIARQTAQ 562
+++K +H ++ ++ + IVT++ SL L E + ++ L+D+A Q A
Sbjct: 314 IMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAA 373
Query: 563 GMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGS---ILW 619
GM Y+ + IHRDL+S NI + L KI DFGLA R +++ G+ I W
Sbjct: 374 GMAYIERMNYIHRDLRSANILVGNGLICKIADFGLA----RLIEDNEYTARQGAKFPIKW 429
Query: 620 MAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDL 678
APE ++ +SDV++FGI+L EL+T G++PY +NNR +++ V RGY P
Sbjct: 430 TAPEAALY---GRFTIKSDVWSFGILLTELVTKGRVPYPGMNNR-EVLEQVERGYRMP-- 483
Query: 679 SKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
+CP ++ LM C KK +ERP F + + +E
Sbjct: 484 --CPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLE 518
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 137 bits (345), Expect = 4e-32
Identities = 90/264 (34%), Positives = 144/264 (54%), Gaps = 15/264 (5%)
Query: 448 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRK 507
DDWE P + T+ +++GSG FG V++G W V V + ++ Q ++E+ ++K
Sbjct: 182 DDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKK 241
Query: 508 TRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETK-FEMIKLIDIARQTAQGMD 565
RH +IL L+ S + I+T+ SL L + K + +L+DIA Q A+GM
Sbjct: 242 LRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMC 301
Query: 566 YLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLA-TVKSRWSGSHQFEQLSGSILWMAPEV 624
YL +++ IHRDL + NI + E+ K+GDFGLA +K SH + W APE
Sbjct: 302 YLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH---NIPYKWTAPEA 358
Query: 625 IRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 683
+ + YS +SDV++FGI+L+E+ + GQ+PY ++N + + V GY P
Sbjct: 359 L---SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFL-RVDAGYRMP----CPL 410
Query: 684 NCPKAMKRLMAECLKKKRDERPLF 707
CP ++ +LM C + ++RP F
Sbjct: 411 ECPPSVHKLMLTCWCRDPEQRPCF 434
>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
sapiens]
Length = 983
Score = 136 bits (343), Expect = 6e-32
Identities = 98/294 (33%), Positives = 158/294 (53%), Gaps = 21/294 (7%)
Query: 451 EIPDGQITVGQRIGSGSFGTVYKG------KWHGDVAVKMLNVTAPTPQQLQAFKNEVGV 504
E+ I++ + +G+G FG V G K VA+K L V T +Q + F E +
Sbjct: 615 ELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKV-GYTEKQRRDFLGEASI 673
Query: 505 LRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG 563
+ + H NI+ G TK + + IVT++ E SL L + +F +I+L+ + R A G
Sbjct: 674 MGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASG 733
Query: 564 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV-KSRWSGSHQFEQLSGSILWMAP 622
M YL +HRDL + NI ++ +L K+ DFGL+ V + ++ I W +P
Sbjct: 734 MKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSP 793
Query: 623 EVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKV 681
E I + ++ SDV+++GIVL+E+M+ G+ PY ++N+D +I V GY P
Sbjct: 794 EAIAYR---KFTSASDVWSYGIVLWEVMSYGERPYWEMSNQD-VIKAVDEGYRLPP---- 845
Query: 682 RSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLAR---SLPKIHRSASEPS 732
+CP A+ +LM +C +K R+ RP F QI++ ++ L R SL I +A+ PS
Sbjct: 846 PMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPS 899
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 135 bits (341), Expect = 1e-31
Identities = 96/284 (33%), Positives = 150/284 (52%), Gaps = 24/284 (8%)
Query: 439 KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLNVTAPTPQQLQ 496
+TLG + D WEI IT+ +R+G+G FG V+ G W+G VAVK L +P+
Sbjct: 247 QTLGL--AKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPK--- 301
Query: 497 AFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQW-CEGSSLYHHLHIIETKFEMIKLID 555
AF E V++ RH ++ ++ + IVT++ C GS L + + +L+D
Sbjct: 302 AFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVD 361
Query: 556 IARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSG 615
+A Q A+GM Y+ + IHRDL++ NI + E L KI DFGLA R ++ G
Sbjct: 362 MAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLA----RLIKDDEYNPCQG 417
Query: 616 S---ILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGR 671
S I W APE ++ +SDV++FGI+L EL+T G++PY +N R +++ V +
Sbjct: 418 SKFPIKWTAPEAALF---GRFTIKSDVWSFGILLTELITKGRIPYPGMNKR-EVLEQVEQ 473
Query: 672 GYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
GY P CP ++ M + + +ERP F + + +E
Sbjct: 474 GYHMP----CPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 135 bits (341), Expect = 1e-31
Identities = 96/284 (33%), Positives = 150/284 (52%), Gaps = 24/284 (8%)
Query: 439 KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLNVTAPTPQQLQ 496
+TLG + D WEI IT+ +R+G+G FG V+ G W+G VAVK L +P+
Sbjct: 247 QTLGL--AKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPK--- 301
Query: 497 AFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQW-CEGSSLYHHLHIIETKFEMIKLID 555
AF E V++ RH ++ ++ + IVT++ C GS L + + +L+D
Sbjct: 302 AFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVD 361
Query: 556 IARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSG 615
+A Q A+GM Y+ + IHRDL++ NI + E L KI DFGLA R ++ G
Sbjct: 362 MAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLA----RLIKDDEYNPCQG 417
Query: 616 S---ILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGR 671
S I W APE ++ +SDV++FGI+L EL+T G++PY +N R +++ V +
Sbjct: 418 SKFPIKWTAPEAALF---GRFTIKSDVWSFGILLTELITKGRIPYPGMNKR-EVLEQVEQ 473
Query: 672 GYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
GY P CP ++ M + + +ERP F + + +E
Sbjct: 474 GYHMP----CPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 135 bits (341), Expect = 1e-31
Identities = 96/284 (33%), Positives = 150/284 (52%), Gaps = 24/284 (8%)
Query: 439 KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLNVTAPTPQQLQ 496
+TLG + D WEI IT+ +R+G+G FG V+ G W+G VAVK L +P+
Sbjct: 247 QTLGL--AKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPK--- 301
Query: 497 AFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQW-CEGSSLYHHLHIIETKFEMIKLID 555
AF E V++ RH ++ ++ + IVT++ C GS L + + +L+D
Sbjct: 302 AFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVD 361
Query: 556 IARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSG 615
+A Q A+GM Y+ + IHRDL++ NI + E L KI DFGLA R ++ G
Sbjct: 362 MAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLA----RLIKDDEYNPCQG 417
Query: 616 S---ILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGR 671
S I W APE ++ +SDV++FGI+L EL+T G++PY +N R +++ V +
Sbjct: 418 SKFPIKWTAPEAALF---GRFTIKSDVWSFGILLTELITKGRIPYPGMNKR-EVLEQVEQ 473
Query: 672 GYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 715
GY P CP ++ M + + +ERP F + + +E
Sbjct: 474 GYHMP----CPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
>gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo
sapiens]
Length = 1005
Score = 134 bits (338), Expect = 2e-31
Identities = 98/298 (32%), Positives = 152/298 (51%), Gaps = 20/298 (6%)
Query: 442 GRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD------VAVKMLNVTAPTPQQL 495
GR S EI +I + + IGSG G V G+ VA+K L T +Q
Sbjct: 620 GRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKA-GYTERQR 678
Query: 496 QAFKNEVGVLRKTRHVNILLFMGYSTKPQLA-IVTQWCEGSSLYHHLHIIETKFEMIKLI 554
+ F +E ++ + H NI+ G T+ +LA IVT++ E SL L + +F +++L+
Sbjct: 679 RDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLV 738
Query: 555 DIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLS 614
+ R GM YL +HRDL + N+ + +L K+ DFGL+ V +
Sbjct: 739 GMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLED-DPDAAYTTTG 797
Query: 615 GS--ILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGR 671
G I W APE I + +S SDV++FG+V++E++ G+ PY N+ NRD +I V
Sbjct: 798 GKIPIRWTAPEAIAFR---TFSSASDVWSFGVVMWEVLAYGERPYWNMTNRD-VISSVEE 853
Query: 672 GYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSAS 729
GY P CP A+ +LM +C K R +RP F QI++ ++ L RS + +A+
Sbjct: 854 GYRLP----APMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPESLRATAT 907
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 134 bits (337), Expect = 3e-31
Identities = 89/276 (32%), Positives = 151/276 (54%), Gaps = 20/276 (7%)
Query: 446 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLNVTAPTPQQLQAFKNEVG 503
+ D+WEIP + + +++GSG FG V+ G + + VA+K L +P+ AF E
Sbjct: 230 AQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPE---AFLGEAN 286
Query: 504 VLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIE-TKFEMIKLIDIARQTAQ 562
V++ +H ++ TK + IVT++ L L E ++ + +LID++ Q A+
Sbjct: 287 VMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAE 346
Query: 563 GMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLA-TVKSRWSGSHQFEQLSGSILWMA 621
GM Y+ + IHRDL++ NI + E L KI DFGLA + S ++ E I W A
Sbjct: 347 GMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQ---EGAKFPIKWTA 403
Query: 622 PEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSK 680
PE I ++ ++DV++FG++L E++T G++PY ++N ++I + RGY P
Sbjct: 404 PEAIHF---GVFTIKADVWSFGVLLMEVVTYGRVPYPGMSN-PEVIRNLERGYRMPR--- 456
Query: 681 VRSNCPKAMKR-LMAECLKKKRDERPLFPQILASIE 715
CP + R ++AEC + + +ERP F + + +E
Sbjct: 457 -PDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLE 491
>gi|32528301 EPH receptor B4 precursor [Homo sapiens]
Length = 987
Score = 132 bits (333), Expect = 9e-31
Identities = 86/281 (30%), Positives = 152/281 (54%), Gaps = 20/281 (7%)
Query: 451 EIPDGQITVGQRIGSGSFGTVYKG------KWHGDVAVKMLNVTAPTPQQLQAFKNEVGV 504
EI + + + IG+G FG V +G K VA+K L T +Q + F +E +
Sbjct: 609 EIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK-GGYTERQRREFLSEASI 667
Query: 505 LRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG 563
+ + H NI+ G T + I+T++ E +L L + + +F +I+L+ + R A G
Sbjct: 668 MGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASG 727
Query: 564 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGS---ILWM 620
M YL S +HRDL + NI ++ +L K+ DFGL+ S + G I W
Sbjct: 728 MRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWT 787
Query: 621 APEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLS 679
APE I + ++ SD +++GIV++E+M+ G+ PY +++N+D +I + + Y P
Sbjct: 788 APEAIAFR---KFTSASDAWSYGIVMWEVMSFGERPYWDMSNQD-VINAIEQDYRLPP-- 841
Query: 680 KVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS 720
+CP ++ +LM +C +K R+ RP FPQ++++++ + R+
Sbjct: 842 --PPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRN 880
>gi|4758280 ephrin receptor EphA4 [Homo sapiens]
Length = 986
Score = 130 bits (328), Expect = 4e-30
Identities = 110/383 (28%), Positives = 188/383 (49%), Gaps = 37/383 (9%)
Query: 375 EPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSED 434
EP+ + GDG ++T L + S+ + + A S +R K S + ++
Sbjct: 526 EPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAAFVIS---RRRSKYSKAKQE 582
Query: 435 RNRMKTL--GRRDSSDDW--------------EIPDGQITVGQRIGSGSFGTVYKGKWHG 478
+ K L G R D + EI I + + IG G FG V G+
Sbjct: 583 ADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKV 642
Query: 479 D------VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQ-LAIVTQW 531
VA+K L T +Q + F +E ++ + H NI+ G TK + + I+T++
Sbjct: 643 PGKREICVAIKTLKA-GYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEY 701
Query: 532 CEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVK 591
E SL L + +F +I+L+ + R GM YL S +HRDL + NI ++ +L K
Sbjct: 702 MENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCK 761
Query: 592 IGDFGLATV-KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM 650
+ DFG++ V + ++ I W APE I + ++ SDV+++GIV++E+M
Sbjct: 762 VSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYR---KFTSASDVWSYGIVMWEVM 818
Query: 651 T-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQ 709
+ G+ PY +++N+D +I + GY P +CP A+ +LM +C +K+R +RP F Q
Sbjct: 819 SYGERPYWDMSNQD-VIKAIEEGYRLPP----PMDCPIALHQLMLDCWQKERSDRPKFGQ 873
Query: 710 ILASIELLARSLPKIHRSASEPS 732
I+ ++ L R+ + R+ +E S
Sbjct: 874 IVNMLDKLIRNPNSLKRTGTESS 896
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 130 bits (327), Expect = 5e-30
Identities = 94/303 (31%), Positives = 164/303 (54%), Gaps = 26/303 (8%)
Query: 451 EIPDGQITVGQRIGSGSFGTVYKG------KWHGDVAVKMLNVTAPTPQQLQAFKNEVGV 504
EI + + + IG+G FG VYKG K VA+K L + +Q + F +E +
Sbjct: 613 EIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKA-GYSEKQRRDFLSEASI 671
Query: 505 LRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG 563
+ + H NI+ G TK + + I+T++ E +L L + +F +I+L+ + R A G
Sbjct: 672 MGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAG 731
Query: 564 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAT-VKSRWSGSHQFEQLSGSI--LWM 620
M YL + +HRDL + NI ++ +L K+ DFGL+ ++ S L G I W
Sbjct: 732 MKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWT 791
Query: 621 APEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLS 679
APE I + ++ SDV+++GIV++E+M+ G+ PY +++N+D +I + + Y P
Sbjct: 792 APEAIAYR---KFTSASDVWSYGIVMWEVMSFGERPYWDMSNQD-VINAIEQDYRLPP-- 845
Query: 680 KVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSA------SEPSL 733
+CP A+ +LM +C +K R+ RP F +I+ +++ + R+ + A S+P L
Sbjct: 846 --PMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLL 903
Query: 734 NRA 736
+R+
Sbjct: 904 DRS 906
>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo
sapiens]
Length = 1015
Score = 129 bits (325), Expect = 8e-30
Identities = 92/279 (32%), Positives = 150/279 (53%), Gaps = 18/279 (6%)
Query: 451 EIPDGQITVGQRIGSGSFGTVYKG------KWHGDVAVKMLNVTAPTPQQLQAFKNEVGV 504
EI IT+ + IG+G FG V G K VA+K L V T +Q + F E +
Sbjct: 647 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKV-GYTEKQRRDFLGEASI 705
Query: 505 LRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG 563
+ + H NI+ G TK + + IVT++ E SL L + +F +I+L+ + R + G
Sbjct: 706 MGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAG 765
Query: 564 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV-KSRWSGSHQFEQLSGSILWMAP 622
M YL +HRDL + NI ++ +L K+ DFGL+ V + ++ I W AP
Sbjct: 766 MKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAP 825
Query: 623 EVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKV 681
E I + ++ SDV+++GIV++E+++ G+ PY + N+D +I V GY P
Sbjct: 826 EAIAFR---KFTSASDVWSYGIVMWEVVSYGERPYWEMTNQD-VIKAVEEGYRLPS---- 877
Query: 682 RSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS 720
+CP A+ +LM +C +K+R+ RP F +I+ ++ L R+
Sbjct: 878 PMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRN 916
>gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo
sapiens]
Length = 1037
Score = 129 bits (325), Expect = 8e-30
Identities = 92/279 (32%), Positives = 150/279 (53%), Gaps = 18/279 (6%)
Query: 451 EIPDGQITVGQRIGSGSFGTVYKG------KWHGDVAVKMLNVTAPTPQQLQAFKNEVGV 504
EI IT+ + IG+G FG V G K VA+K L V T +Q + F E +
Sbjct: 669 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKV-GYTEKQRRDFLGEASI 727
Query: 505 LRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG 563
+ + H NI+ G TK + + IVT++ E SL L + +F +I+L+ + R + G
Sbjct: 728 MGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAG 787
Query: 564 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV-KSRWSGSHQFEQLSGSILWMAP 622
M YL +HRDL + NI ++ +L K+ DFGL+ V + ++ I W AP
Sbjct: 788 MKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAP 847
Query: 623 EVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKV 681
E I + ++ SDV+++GIV++E+++ G+ PY + N+D +I V GY P
Sbjct: 848 EAIAFR---KFTSASDVWSYGIVMWEVVSYGERPYWEMTNQD-VIKAVEEGYRLPS---- 899
Query: 682 RSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS 720
+CP A+ +LM +C +K+R+ RP F +I+ ++ L R+
Sbjct: 900 PMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRN 938
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,446,775
Number of Sequences: 37866
Number of extensions: 1569869
Number of successful extensions: 12115
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 692
Number of HSP's successfully gapped in prelim test: 226
Number of HSP's that attempted gapping in prelim test: 9258
Number of HSP's gapped (non-prelim): 1712
length of query: 766
length of database: 18,247,518
effective HSP length: 110
effective length of query: 656
effective length of database: 14,082,258
effective search space: 9237961248
effective search space used: 9237961248
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.