Search of human proteins with 32967601

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
         (4377 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                       8626   0.0  
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                       2140   0.0  
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                       2139   0.0  
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                      2125   0.0  
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                      1784   0.0  
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                       1743   0.0  
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                       1743   0.0  
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                       1743   0.0  
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                       1743   0.0  
gi|32967599 ankyrin 3 isoform 2 [Homo sapiens]                       1197   0.0  
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   328   7e-89
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   324   1e-87
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   310   2e-83
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   303   3e-81
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   301   1e-80
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   301   1e-80
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  291   7e-78
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   242   5e-63
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   232   5e-60
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   222   7e-57
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    222   7e-57
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform...   219   5e-56
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    192   6e-48
gi|34304381 inversin isoform a [Homo sapiens]                         190   3e-47
gi|34304379 inversin isoform b [Homo sapiens]                         190   3e-47
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   185   1e-45
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   185   1e-45
gi|116534990 ankyrin-like protein 1 [Homo sapiens]                    178   9e-44
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   177   2e-43
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]            166   5e-40

>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 8626 bits (22384), Expect = 0.0
 Identities = 4377/4377 (100%), Positives = 4377/4377 (100%)

Query: 1    MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDY 60
            MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDY
Sbjct: 1    MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDY 60

Query: 61   IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA 120
            IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA
Sbjct: 61   IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA 120

Query: 121  EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180
            EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA
Sbjct: 121  EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180

Query: 181  LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH 240
            LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH
Sbjct: 181  LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH 240

Query: 241  IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD 300
            IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD
Sbjct: 241  IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD 300

Query: 301  GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPV 360
            GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPV
Sbjct: 301  GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPV 360

Query: 361  DDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLL 420
            DDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLL
Sbjct: 361  DDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLL 420

Query: 421  KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE 480
            KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE
Sbjct: 421  KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE 480

Query: 481  VVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSA 540
            VVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSA
Sbjct: 481  VVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSA 540

Query: 541  REGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLT 600
            REGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLT
Sbjct: 541  REGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLT 600

Query: 601  PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV 660
            PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV
Sbjct: 601  PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV 660

Query: 661  TRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG 720
            TRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG
Sbjct: 661  TRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG 720

Query: 721  AHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIIN 780
            AHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIIN
Sbjct: 721  AHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIIN 780

Query: 781  VLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETM 840
            VLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETM
Sbjct: 781  VLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETM 840

Query: 841  NEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAE 900
            NEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAE
Sbjct: 841  NEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAE 900

Query: 901  GYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSL 960
            GYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSL
Sbjct: 901  GYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSL 960

Query: 961  RHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRI 1020
            RHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRI
Sbjct: 961  RHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRI 1020

Query: 1021 TCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVL 1080
            TCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVL
Sbjct: 1021 TCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVL 1080

Query: 1081 RSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDFPQYFAVVSRI 1140
            RSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDFPQYFAVVSRI
Sbjct: 1081 RSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDFPQYFAVVSRI 1140

Query: 1141 KQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGNKATFS 1200
            KQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGNKATFS
Sbjct: 1141 KQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGNKATFS 1200

Query: 1201 PIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDI 1260
            PIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDI
Sbjct: 1201 PIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDI 1260

Query: 1261 TGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPYMAKFVVFAKM 1320
            TGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPYMAKFVVFAKM
Sbjct: 1261 TGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPYMAKFVVFAKM 1320

Query: 1321 NDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGG 1380
            NDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGG
Sbjct: 1321 NDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGG 1380

Query: 1381 QQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHK 1440
            QQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHK
Sbjct: 1381 QQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHK 1440

Query: 1441 KETESDQDDEIEKTDRRQSFASLALRKRYSYLTEPGMIERSTGATRSLPTTYSYKPFFST 1500
            KETESDQDDEIEKTDRRQSFASLALRKRYSYLTEPGMIERSTGATRSLPTTYSYKPFFST
Sbjct: 1441 KETESDQDDEIEKTDRRQSFASLALRKRYSYLTEPGMIERSTGATRSLPTTYSYKPFFST 1500

Query: 1501 RPYQSWTTAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSS 1560
            RPYQSWTTAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSS
Sbjct: 1501 RPYQSWTTAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSS 1560

Query: 1561 VKSISDVASPIRSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAVTEATPLKGLASNSTF 1620
            VKSISDVASPIRSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAVTEATPLKGLASNSTF
Sbjct: 1561 VKSISDVASPIRSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAVTEATPLKGLASNSTF 1620

Query: 1621 SSRTSPVTTAGSLLERSSITMTPPASPKSNINMYSSSLPFKSIITSAAPLISSPLKSVVS 1680
            SSRTSPVTTAGSLLERSSITMTPPASPKSNINMYSSSLPFKSIITSAAPLISSPLKSVVS
Sbjct: 1621 SSRTSPVTTAGSLLERSSITMTPPASPKSNINMYSSSLPFKSIITSAAPLISSPLKSVVS 1680

Query: 1681 PVKSAVDVISSAKITMASSLSSPVKQMPGHAEVALVNGSISPLKYPSSSTLINGCKATAT 1740
            PVKSAVDVISSAKITMASSLSSPVKQMPGHAEVALVNGSISPLKYPSSSTLINGCKATAT
Sbjct: 1681 PVKSAVDVISSAKITMASSLSSPVKQMPGHAEVALVNGSISPLKYPSSSTLINGCKATAT 1740

Query: 1741 LQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFSPLRSYVSAAPSAFQSLRTPSASAL 1800
            LQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFSPLRSYVSAAPSAFQSLRTPSASAL
Sbjct: 1741 LQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFSPLRSYVSAAPSAFQSLRTPSASAL 1800

Query: 1801 YTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPALKKLPDSNSFTKSAAALLSPIKTLT 1860
            YTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPALKKLPDSNSFTKSAAALLSPIKTLT
Sbjct: 1801 YTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPALKKLPDSNSFTKSAAALLSPIKTLT 1860

Query: 1861 TETHPQPHFSRTSSPVKSSLFLAPSALKLSTPSSLSSSQEILKDVAEMKEDLMRMTAILQ 1920
            TETHPQPHFSRTSSPVKSSLFLAPSALKLSTPSSLSSSQEILKDVAEMKEDLMRMTAILQ
Sbjct: 1861 TETHPQPHFSRTSSPVKSSLFLAPSALKLSTPSSLSSSQEILKDVAEMKEDLMRMTAILQ 1920

Query: 1921 TDVPEEKPFQPELPKEGRIDDEEPFKIVEKVKEDLVKVSEILKKDVCVDNKGSPKSPKSD 1980
            TDVPEEKPFQPELPKEGRIDDEEPFKIVEKVKEDLVKVSEILKKDVCVDNKGSPKSPKSD
Sbjct: 1921 TDVPEEKPFQPELPKEGRIDDEEPFKIVEKVKEDLVKVSEILKKDVCVDNKGSPKSPKSD 1980

Query: 1981 KGHSPEDDWIEFSSEEIREARQQAAASQSPSLPERVQVKAKAASEKDYNLTKVIDYLTND 2040
            KGHSPEDDWIEFSSEEIREARQQAAASQSPSLPERVQVKAKAASEKDYNLTKVIDYLTND
Sbjct: 1981 KGHSPEDDWIEFSSEEIREARQQAAASQSPSLPERVQVKAKAASEKDYNLTKVIDYLTND 2040

Query: 2041 IGSSSLTNLKYKFEDAKKDGEERQKRVLKPAIALQEHKLKMPPASMRTSTSEKELCKMAD 2100
            IGSSSLTNLKYKFEDAKKDGEERQKRVLKPAIALQEHKLKMPPASMRTSTSEKELCKMAD
Sbjct: 2041 IGSSSLTNLKYKFEDAKKDGEERQKRVLKPAIALQEHKLKMPPASMRTSTSEKELCKMAD 2100

Query: 2101 SFFGTDTILESPDDFSQHDQDKSPLSDSGFETRSEKTPSAPQSAESTGPKPLFHEVPIPP 2160
            SFFGTDTILESPDDFSQHDQDKSPLSDSGFETRSEKTPSAPQSAESTGPKPLFHEVPIPP
Sbjct: 2101 SFFGTDTILESPDDFSQHDQDKSPLSDSGFETRSEKTPSAPQSAESTGPKPLFHEVPIPP 2160

Query: 2161 VITETRTEVVHVIRSYDPSAGDVPQTQPEEPVSPKPSPTFMELEPKPTTSSIKEKVKAFQ 2220
            VITETRTEVVHVIRSYDPSAGDVPQTQPEEPVSPKPSPTFMELEPKPTTSSIKEKVKAFQ
Sbjct: 2161 VITETRTEVVHVIRSYDPSAGDVPQTQPEEPVSPKPSPTFMELEPKPTTSSIKEKVKAFQ 2220

Query: 2221 MKASSEEDDHNRVLSKGMRVKEETHITTTTRMVYHSPPGGEGASERIEETMSVHDIMKAF 2280
            MKASSEEDDHNRVLSKGMRVKEETHITTTTRMVYHSPPGGEGASERIEETMSVHDIMKAF
Sbjct: 2221 MKASSEEDDHNRVLSKGMRVKEETHITTTTRMVYHSPPGGEGASERIEETMSVHDIMKAF 2280

Query: 2281 QSGRDPSKELAGLFEHKSAVSPDVHKSAAETSAQHAEKDNQMKPKLERIIEVHIEKGNQA 2340
            QSGRDPSKELAGLFEHKSAVSPDVHKSAAETSAQHAEKDNQMKPKLERIIEVHIEKGNQA
Sbjct: 2281 QSGRDPSKELAGLFEHKSAVSPDVHKSAAETSAQHAEKDNQMKPKLERIIEVHIEKGNQA 2340

Query: 2341 EPTEVIIRETKKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAE 2400
            EPTEVIIRETKKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAE
Sbjct: 2341 EPTEVIIRETKKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAE 2400

Query: 2401 ESLPSYLESSRVNTPVSQEEDSRPSSAQLISDDSYKTLKLLSQHSIEYHDDELSELRGES 2460
            ESLPSYLESSRVNTPVSQEEDSRPSSAQLISDDSYKTLKLLSQHSIEYHDDELSELRGES
Sbjct: 2401 ESLPSYLESSRVNTPVSQEEDSRPSSAQLISDDSYKTLKLLSQHSIEYHDDELSELRGES 2460

Query: 2461 YRFAEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIYK 2520
            YRFAEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIYK
Sbjct: 2461 YRFAEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIYK 2520

Query: 2521 DVSENGVGKVSKDEHFDKVTVLHYSGNVSSPKHAMWMRFTEDRLDRGREKLIYEDRVDRT 2580
            DVSENGVGKVSKDEHFDKVTVLHYSGNVSSPKHAMWMRFTEDRLDRGREKLIYEDRVDRT
Sbjct: 2521 DVSENGVGKVSKDEHFDKVTVLHYSGNVSSPKHAMWMRFTEDRLDRGREKLIYEDRVDRT 2580

Query: 2581 VKEAEEKLTEVSQFFRDKTEKLNDELQSPEKKARPKNGKEYSSQSPTSSSPEKVLLTELL 2640
            VKEAEEKLTEVSQFFRDKTEKLNDELQSPEKKARPKNGKEYSSQSPTSSSPEKVLLTELL
Sbjct: 2581 VKEAEEKLTEVSQFFRDKTEKLNDELQSPEKKARPKNGKEYSSQSPTSSSPEKVLLTELL 2640

Query: 2641 ASNDEWVKARQHGPDGQGFPKAEEKAPSLPSSPEKMVLSQQTEDSKSTVEAKGSISQSKA 2700
            ASNDEWVKARQHGPDGQGFPKAEEKAPSLPSSPEKMVLSQQTEDSKSTVEAKGSISQSKA
Sbjct: 2641 ASNDEWVKARQHGPDGQGFPKAEEKAPSLPSSPEKMVLSQQTEDSKSTVEAKGSISQSKA 2700

Query: 2701 PDGPQSGFQLKQSKLSSIRLKFEQGTHAKSKDMSQEDRKSDGQSRIPVKKIQESKLPVYQ 2760
            PDGPQSGFQLKQSKLSSIRLKFEQGTHAKSKDMSQEDRKSDGQSRIPVKKIQESKLPVYQ
Sbjct: 2701 PDGPQSGFQLKQSKLSSIRLKFEQGTHAKSKDMSQEDRKSDGQSRIPVKKIQESKLPVYQ 2760

Query: 2761 VFAREKQQKAIDLPDESVSVQKDFMVLKTKDEHAQSNEIVVNDSGSDNVKKQRTEMSSKA 2820
            VFAREKQQKAIDLPDESVSVQKDFMVLKTKDEHAQSNEIVVNDSGSDNVKKQRTEMSSKA
Sbjct: 2761 VFAREKQQKAIDLPDESVSVQKDFMVLKTKDEHAQSNEIVVNDSGSDNVKKQRTEMSSKA 2820

Query: 2821 MPDSFSEQQAKDLACHITSDLATRGPWDKKVFRTWESSGATNNKSQKEKLSHVLVHDVRE 2880
            MPDSFSEQQAKDLACHITSDLATRGPWDKKVFRTWESSGATNNKSQKEKLSHVLVHDVRE
Sbjct: 2821 MPDSFSEQQAKDLACHITSDLATRGPWDKKVFRTWESSGATNNKSQKEKLSHVLVHDVRE 2880

Query: 2881 NHIGHPESKSVDQKNEFMSVTERERKLLTNGSLSEIKEMTVKSPSKKVLYREYVVKEGDH 2940
            NHIGHPESKSVDQKNEFMSVTERERKLLTNGSLSEIKEMTVKSPSKKVLYREYVVKEGDH
Sbjct: 2881 NHIGHPESKSVDQKNEFMSVTERERKLLTNGSLSEIKEMTVKSPSKKVLYREYVVKEGDH 2940

Query: 2941 PGGLLDQPSRRSESSAVSHIPVRVADERRMLSSNIPDGFCEQSAFPKHELSQKLSQSSMS 3000
            PGGLLDQPSRRSESSAVSHIPVRVADERRMLSSNIPDGFCEQSAFPKHELSQKLSQSSMS
Sbjct: 2941 PGGLLDQPSRRSESSAVSHIPVRVADERRMLSSNIPDGFCEQSAFPKHELSQKLSQSSMS 3000

Query: 3001 KETVETQHFNSIEDEKVTYSEISKVSKHQSYVGLCPPLEETETSPTKSPDSLEFSPGKES 3060
            KETVETQHFNSIEDEKVTYSEISKVSKHQSYVGLCPPLEETETSPTKSPDSLEFSPGKES
Sbjct: 3001 KETVETQHFNSIEDEKVTYSEISKVSKHQSYVGLCPPLEETETSPTKSPDSLEFSPGKES 3060

Query: 3061 PSSDVFDHSPIDGLEKLAPLAQTEGGKEIKTLPVYVSFVQVGKQYEKEIQQGGVKKIISQ 3120
            PSSDVFDHSPIDGLEKLAPLAQTEGGKEIKTLPVYVSFVQVGKQYEKEIQQGGVKKIISQ
Sbjct: 3061 PSSDVFDHSPIDGLEKLAPLAQTEGGKEIKTLPVYVSFVQVGKQYEKEIQQGGVKKIISQ 3120

Query: 3121 ECKTVQETRGTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSGKSPLTPETPSSEEVSYE 3180
            ECKTVQETRGTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSGKSPLTPETPSSEEVSYE
Sbjct: 3121 ECKTVQETRGTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSGKSPLTPETPSSEEVSYE 3180

Query: 3181 FTSKTPDSLIAYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAVEREMPNDVSKDS 3240
            FTSKTPDSLIAYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAVEREMPNDVSKDS
Sbjct: 3181 FTSKTPDSLIAYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAVEREMPNDVSKDS 3240

Query: 3241 NQRPKNNRVAYIEFPPPPPLDADQIESDKKHHYLPEKEVDMIEVNLQDEHDKYQLAEPVI 3300
            NQRPKNNRVAYIEFPPPPPLDADQIESDKKHHYLPEKEVDMIEVNLQDEHDKYQLAEPVI
Sbjct: 3241 NQRPKNNRVAYIEFPPPPPLDADQIESDKKHHYLPEKEVDMIEVNLQDEHDKYQLAEPVI 3300

Query: 3301 RVQPPSPVPPGADVSDSSDDESIYQPVPVKKYTFKLKEVDDEQKEKPKASAEKASNQKEL 3360
            RVQPPSPVPPGADVSDSSDDESIYQPVPVKKYTFKLKEVDDEQKEKPKASAEKASNQKEL
Sbjct: 3301 RVQPPSPVPPGADVSDSSDDESIYQPVPVKKYTFKLKEVDDEQKEKPKASAEKASNQKEL 3360

Query: 3361 ESNGSGKDNEFGLGLDSPQNEIAQNGNNDQSITECSIATTAEFSHDTDATEIDSLDGYDL 3420
            ESNGSGKDNEFGLGLDSPQNEIAQNGNNDQSITECSIATTAEFSHDTDATEIDSLDGYDL
Sbjct: 3361 ESNGSGKDNEFGLGLDSPQNEIAQNGNNDQSITECSIATTAEFSHDTDATEIDSLDGYDL 3420

Query: 3421 QDEDDGLTESDSKLPIQAMEIKKDIWNTEGILKPADRSFSQSKLEVIEEEGKVGPDEDKP 3480
            QDEDDGLTESDSKLPIQAMEIKKDIWNTEGILKPADRSFSQSKLEVIEEEGKVGPDEDKP
Sbjct: 3421 QDEDDGLTESDSKLPIQAMEIKKDIWNTEGILKPADRSFSQSKLEVIEEEGKVGPDEDKP 3480

Query: 3481 PSKSSSSEKTPDKTDQKSGAQFFTLEGRHPDRSVFPDTYFSYKVDEEFATPFKTVATKGL 3540
            PSKSSSSEKTPDKTDQKSGAQFFTLEGRHPDRSVFPDTYFSYKVDEEFATPFKTVATKGL
Sbjct: 3481 PSKSSSSEKTPDKTDQKSGAQFFTLEGRHPDRSVFPDTYFSYKVDEEFATPFKTVATKGL 3540

Query: 3541 DFDPWSNNRGDDEVFDSKSREDETKPFGLAVEDRSPATTPDTTPARTPTDESTPTSEPNP 3600
            DFDPWSNNRGDDEVFDSKSREDETKPFGLAVEDRSPATTPDTTPARTPTDESTPTSEPNP
Sbjct: 3541 DFDPWSNNRGDDEVFDSKSREDETKPFGLAVEDRSPATTPDTTPARTPTDESTPTSEPNP 3600

Query: 3601 FPFHEGKMFEMTRSGAIDMSKRDFVEERLQFFQIGEHTSEGKSGDQGEGDKSMVTATPQP 3660
            FPFHEGKMFEMTRSGAIDMSKRDFVEERLQFFQIGEHTSEGKSGDQGEGDKSMVTATPQP
Sbjct: 3601 FPFHEGKMFEMTRSGAIDMSKRDFVEERLQFFQIGEHTSEGKSGDQGEGDKSMVTATPQP 3660

Query: 3661 QSGDTTVETNLERNVETPTVEPNPSIPTSGECQEGTSSSGSLEKSAAATNTSKVDPKLRT 3720
            QSGDTTVETNLERNVETPTVEPNPSIPTSGECQEGTSSSGSLEKSAAATNTSKVDPKLRT
Sbjct: 3661 QSGDTTVETNLERNVETPTVEPNPSIPTSGECQEGTSSSGSLEKSAAATNTSKVDPKLRT 3720

Query: 3721 PIKMGISASTMTMKKEGPGEITDKIEAVMTSCQGLENETITMISNTANSQMGVRPHEKHD 3780
            PIKMGISASTMTMKKEGPGEITDKIEAVMTSCQGLENETITMISNTANSQMGVRPHEKHD
Sbjct: 3721 PIKMGISASTMTMKKEGPGEITDKIEAVMTSCQGLENETITMISNTANSQMGVRPHEKHD 3780

Query: 3781 FQKDNFNNNNNLDSSTIQTDNIMSNIVLTEHSAPTCTTEKDNPVKVSSGKKTGVLQGHCV 3840
            FQKDNFNNNNNLDSSTIQTDNIMSNIVLTEHSAPTCTTEKDNPVKVSSGKKTGVLQGHCV
Sbjct: 3781 FQKDNFNNNNNLDSSTIQTDNIMSNIVLTEHSAPTCTTEKDNPVKVSSGKKTGVLQGHCV 3840

Query: 3841 RDKQKVLGEQQKTKELIGIRQKSKLPIKATSPKDTFPPNHMSNTKASKMKQVSQSEKTKA 3900
            RDKQKVLGEQQKTKELIGIRQKSKLPIKATSPKDTFPPNHMSNTKASKMKQVSQSEKTKA
Sbjct: 3841 RDKQKVLGEQQKTKELIGIRQKSKLPIKATSPKDTFPPNHMSNTKASKMKQVSQSEKTKA 3900

Query: 3901 LTTSSCVDVKSRIPVKNTHRDNIIAVRKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVT 3960
            LTTSSCVDVKSRIPVKNTHRDNIIAVRKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVT
Sbjct: 3901 LTTSSCVDVKSRIPVKNTHRDNIIAVRKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVT 3960

Query: 3961 TTTTTATTTTTTTTTTTTSCTVKVRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKK 4020
            TTTTTATTTTTTTTTTTTSCTVKVRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKK
Sbjct: 3961 TTTTTATTTTTTTTTTTTSCTVKVRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKK 4020

Query: 4021 MQSELSDEEESTSRNTSLSETSRGGQPSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRR 4080
            MQSELSDEEESTSRNTSLSETSRGGQPSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRR
Sbjct: 4021 MQSELSDEEESTSRNTSLSETSRGGQPSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRR 4080

Query: 4081 TGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKK 4140
            TGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKK
Sbjct: 4081 TGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKK 4140

Query: 4141 WVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGW 4200
            WVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGW
Sbjct: 4141 WVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGW 4200

Query: 4201 QNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPE 4260
            QNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPE
Sbjct: 4201 QNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPE 4260

Query: 4261 AKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKP 4320
            AKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKP
Sbjct: 4261 AKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKP 4320

Query: 4321 CVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS 4377
            CVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS
Sbjct: 4321 CVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS 4377


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 2140 bits (5544), Expect = 0.0
 Identities = 1075/1489 (72%), Positives = 1247/1489 (83%), Gaps = 78/1489 (5%)

Query: 33   RDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSE 92
            R R KKSD+NAS+LRAARAG+L+K ++Y+K G+DIN CNQNGLNALHLA+KEGHV +V E
Sbjct: 23   RKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQE 82

Query: 93   LLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENH 152
            LL R ++VD+ATKKGNTALHIASLAGQAEVVKVLV  GAN+NAQSQNGFTPLYMAAQENH
Sbjct: 83   LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 142

Query: 153  LEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARK 212
            ++VVK+LL+NGA+QS ATEDGFTPLAVALQQGH+Q V++LLENDTKGKVRLPALHIAARK
Sbjct: 143  IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 202

Query: 213  DDTKAAALLLQNDNNADVESK--------SGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
            DDTK+AALLLQND+NADV+SK        SGFTPLHIAAHYGN+NVATLLLNR AAVDFT
Sbjct: 203  DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262

Query: 265  ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
            ARN ITPLHVASKRGN NMVKLLLDRG +IDAKTRDGLTPLHC ARSGH+QVVE+LL+R 
Sbjct: 263  ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 322

Query: 325  APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAK 384
            AP+L++TKNGLSPLHMA QGDH+ CV+ LLQH  PVDDVT DYLTALHVAAHCGHY+V K
Sbjct: 323  APLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTK 382

Query: 385  VLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMG 444
            +LLDK+ANPNA+ALNGFTPLHIACKKNRIKVMELL+K+GASIQA+TESGLTPIHVAAFMG
Sbjct: 383  LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMG 442

Query: 445  HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLH 504
            H+NIV  L+ +GASP+ TN+RGETALHMAAR+GQ EVVR L+++GA V+A+A+++QTPLH
Sbjct: 443  HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLH 502

Query: 505  ISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKK 564
            I++RLGK +IVQ LLQ  A P+AATT+GYTPLH+SAREG  DVA+ LL+ GA+ S+ TKK
Sbjct: 503  IASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK 562

Query: 565  GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624
            GFTPLHVAAKYG L+VA LLLQ+ A+ D+AGK+GLTPLHVAAHYDNQKVALLLL++GASP
Sbjct: 563  GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622

Query: 625  HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 684
            HA AKNGYTPLHIAAKKNQM IA+TLL YGA+ N VT+QG+  +HLA+QEGH DMV+LLL
Sbjct: 623  HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682

Query: 685  GRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIK 744
             + AN+++S KSGLT LHLAAQED+VNVA++L   GA  DA TK+GYTPL V CHYGN+K
Sbjct: 683  DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742

Query: 745  IVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIAR 804
            +VNFLL+  A VNAKTKNGYTPLHQAAQQGHTHIINVLLQ+ A PN  T NGNTAL IA+
Sbjct: 743  MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802

Query: 805  RLGYISVVDTLKIVTEE-TMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDG 863
            RLGYISVVDTLK+VTEE T TTTT+TEKHK+NVPETM EVLD+SD               
Sbjct: 803  RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSD--------------- 847

Query: 864  EYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAE------GYMGFSL-GARSASLRS 916
                  EEG+D MTGD  +YL P+DLKELGDDSLP+        Y+ +SL G RS SLRS
Sbjct: 848  ------EEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRS 901

Query: 917  FSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLV 976
            FSSDRS+TL+ +SY RDS ++++ +V    Q  T  +E + +S R  SW  + LDNV L 
Sbjct: 902  FSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYR-LSWGTENLDNVALS 960

Query: 977  SSPIHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPM 1036
            SSPIHSGFLVSFMVDARGG+MRG RH+G+RIIIPPRKCTAPTR+TCRLVKRH+LA  PPM
Sbjct: 961  SSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPM 1020

Query: 1037 VEGEGLASRLVEMGPAGAQFLG---------------------------------PVIVE 1063
            VEGEGLASRL+E+GP+GAQFLG                                 PVIVE
Sbjct: 1021 VEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVE 1080

Query: 1064 IPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRIC 1123
            IPHF ++RGKEREL+VLRSENG++WKEH  D   ++L E+LNGMDE LDSPE+L KKRIC
Sbjct: 1081 IPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRIC 1140

Query: 1124 RIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQP 1183
            RIIT+DFPQYFAVVSRIKQ+SN IGPEGG+LSST VP VQA FPEGALTKRIRVGLQAQP
Sbjct: 1141 RIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQP 1200

Query: 1184 VPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLR 1243
            +  E+VKKILGNKATFSPIVT+EPRRRKFHKPITMTIPVP  S + + NG+ GD  P LR
Sbjct: 1201 MHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDA-PTLR 1259

Query: 1244 LLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYR 1303
            LLCSITGGT+PAQWEDITGTTPLTF+ +CVSFTTNVSARFWL DC Q+ E+V  A+Q+YR
Sbjct: 1260 LLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYR 1319

Query: 1304 ELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGK 1363
            E+ICVPYMAKFVVFAK +DP+E+ LRCFCMTDDKVDKTLEQQENF EVARS+D+EVLEGK
Sbjct: 1320 EIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGK 1379

Query: 1364 PIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKG 1423
            PIYVDC+GNL PLTK GQ  +F+F++FKENRLP  +K+RDT+QEPCGRLSF+KEPK+T+G
Sbjct: 1380 PIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRG 1439

Query: 1424 LPQTAVCNLNITLPAHKKETESDQDDE------IEKTDRRQSFASLALR 1466
            L   A+CNLNITLP + KE+ESDQ+ E       EK D  +S  +  L+
Sbjct: 1440 LVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLK 1488



 Score =  322 bits (824), Expect = 7e-87
 Identities = 542/2358 (22%), Positives = 902/2358 (38%), Gaps = 294/2358 (12%)

Query: 1961 ILKKDVCVDNKGSPKSPKSDKGHSPEDDWIEFSSEEIREARQQAAASQSPSLPERVQVKA 2020
            ++ + +C  N   P   K  +    +++ I+ +SE+  E      +     L   V V A
Sbjct: 1440 LVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLA 1499

Query: 2021 KA-----ASEKDYNLTKVIDYLTNDI----GSSSLTNLKYKFEDAKKDGEERQKRVL--- 2068
                    SE   +L K+   LT D+    GS  +  L    E+   +  E  +RV    
Sbjct: 1500 SPDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDL 1559

Query: 2069 -KPAIALQEHKLKMPPASMRTSTSEKELCKMADSFFGTDTILESPDDFSQHDQDKSPLSD 2127
             K    L+        +S+++S SE+ L +        + ++ S ++  +  Q K+PL  
Sbjct: 1560 EKVNEILRSGTCTRDESSVQSSRSERGLVE-------EEWVIVSDEEIEEARQ-KAPLEI 1611

Query: 2128 SGF---ETRSEKTPSAPQSAESTGPKPLFHE-----VPIPPVITET-------RTEVVHV 2172
            + +   E R +K        +STG      +     VP+P    +T       + E + V
Sbjct: 1612 TEYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAV 1671

Query: 2173 IRSYDPSAGDVPQTQPEEPVSPKPSPTFMELEPKPTTSSIKEKVKAFQ--MKASSEEDDH 2230
             RS +    D+P   P+E  S +          KP    +KEK K  +  ++AS+E+ + 
Sbjct: 1672 GRSSEKEGKDIP---PDETQSTQKQHKPSLGIKKPVRRKLKEKQKQKEEGLQASAEKAE- 1727

Query: 2231 NRVLSKGMRVKEETHITTTTRMVYHSPPGGEGASERIEETM--SVHDIMKAFQSGRDPSK 2288
               L KG     E  +     +     P  +  S  IEET   S+ D +KA Q   +  +
Sbjct: 1728 ---LKKG---SSEESLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQ 1781

Query: 2289 ELAGLFEHKSAVSPDV--------HKSAAETSAQHAEKDNQMKPKLERIIEVHIEKGNQA 2340
            +       +     DV        H +A+ +            PK ER   +      + 
Sbjct: 1782 KGRSKLPIRVKGKEDVPKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTER 1841

Query: 2341 EPTEVIIRETKKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAE 2400
             P      +T+KH         +  S    + K    EKH     S +  +      T  
Sbjct: 1842 HPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKT---EKHSPVSPSTKTERHSPVSSTKT 1898

Query: 2401 ESLPSYLESSRVNTPVSQEEDSRPSSAQLISDD-SYKTLKLLSQHSIEYHDDELSELRGE 2459
            E  P    S + +         R      +S   + K L +      + H    +  + E
Sbjct: 1899 ERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTE 1958

Query: 2460 SYRFAEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIY 2519
             +           L VS S   E     +    +E        RE +      +  SK  
Sbjct: 1959 KH-----------LPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHK 2007

Query: 2520 KDVSENGVGKVSKDEHFDKVTVLHYSGNVSSPKHAMWMRFTEDRLDRGREKLIY------ 2573
              + E+   K  + +   KV V    G + + + A   +     + RG+   +       
Sbjct: 2008 TGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQREAQ--KTENQTIKRGQRLPVTGTAESK 2065

Query: 2574 ------------EDRVDRTVKEAEEKLTEVSQFFRDKTEKLNDELQSPEKKARPKNGK-- 2619
                        ED      K    K+ E  Q   +  E+ + E + P++K   + G   
Sbjct: 2066 RGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVPE--EESHRESEVPKEKMADEQGDMD 2123

Query: 2620 -EYSSQSPTSSSPEKVLLTEL--------LASNDEWVKARQH------GPDGQGFPKAEE 2664
             + S    TS+   +V+  EL           ++E  KA+ H       P    FP    
Sbjct: 2124 LQISPDRKTSTDFSEVIKQELEDNDKYQQFRLSEETEKAQLHLDQVLTSPFNTTFPLDYM 2183

Query: 2665 KAPSLPS-SPEKMVLSQQTEDSKSTVEAK---GSISQSKAPDGPQSGFQ----LKQSKLS 2716
            K   LP+ S +   L   +E  K+   A    GS+ +       +  ++     +  + S
Sbjct: 2184 KDEFLPALSLQSGALDGSSESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPETS 2243

Query: 2717 SIRLKFEQGTHAKSKDMSQEDRKSDGQSRIPVKKIQESKLPVYQVFAREKQQKAIDLPDE 2776
               L F      +    ++E  K++  + I  +K   +   +             D    
Sbjct: 2244 PESLSFSPKKSEEQTGETKESTKTETTTEIRSEKEHPTTKDITGGSEERGATVTEDSETS 2303

Query: 2777 SVSVQKDFMVLKTKDEHAQSNEIVVNDSGSDNVKKQRTEMSSKAMPDSFSEQQAKDLACH 2836
            + S QK+  +   KD   +  +   + +GS +V        +K  P   +E+ A D    
Sbjct: 2304 TESFQKEATLGSPKDTSPKRQD---DCTGSCSVAL------AKETPTGLTEEAACDEGQR 2354

Query: 2837 ITSDLATRGPWDKKVFRTWESSGATNNKSQKEKLSHVLVHDVRENHIGHPESKSVDQKNE 2896
                 A +   D +V    + S AT+++++   L    V          P+      +  
Sbjct: 2355 TFGSSAHKTQTDSEV----QESTATSDETKALPLPEASVKTDTGTE-SKPQGVIRSPQGL 2409

Query: 2897 FMSVTERERKLLT---NGSLSEIKEMTVKSPSKKVLYREYVVKEGDHPGGLLDQPSRRS- 2952
             +++  R+ ++L+   + SL+   + ++++         +   +   P  L + P R S 
Sbjct: 2410 ELALPSRDSEVLSAVADDSLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSL 2469

Query: 2953 ESSAVSHIPVRVADERRMLSSNIPDGFCEQSAFPKHELSQKLSQSSMSKETVETQHFNSI 3012
            ESS V         E +M +   P  F   +A  K EL   L++ +  +  +      S 
Sbjct: 2470 ESSPV---------EPKMKAGIFPSHFPLPAAVAKTEL---LTEVASVRSRLLRDPDGSA 2517

Query: 3013 EDEKVTYSEISKVSKHQSYVGLCPPLEETETSPTKSPDSLEFSPGKESPSSDVFDHSPID 3072
            ED+ +  + + + S         P  EE     T  P + + S  K +   +  +    +
Sbjct: 2518 EDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVT--PKTTDVSTPKPAVIHECAEEDDSE 2575

Query: 3073 GLEKLAPLAQTEGGKEIKTLPVYVSFVQVGKQ---YEKEIQQGGVKKIISQECKTVQETR 3129
              EK     + E  K +  + ++    Q  KQ   Y+KE +Q         +     +  
Sbjct: 2576 NGEKKRFTPEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDV- 2634

Query: 3130 GTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSGKSPLTPET-PSSEEVSYEFTSKT-PD 3187
                        P   GS ED++   V     S K   + E+ P   ++     S   P+
Sbjct: 2635 ----------DEPKHTGSGEDESGVPVLVTSESRKVSSSSESEPELAQLKKGADSGLLPE 2684

Query: 3188 SLIAYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAVEREMP--NDVSKDSNQRPK 3245
             +I   P  P P    S  S EE Q +    KQ T +     +E P  ++  KDS     
Sbjct: 2685 PVIRVQPPSPLPSSMDSNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLA 2744

Query: 3246 NNRVAYIEFPPPPPLDADQIESDKKHHYLPEKEVDMIEVNLQDEHDKYQLAEPVIRVQPP 3305
             +R A          +A+    DK +        D  +  + D H    ++         
Sbjct: 2745 EDRHAV-------STEAEDRSYDKLNR-------DTDQPKICDGHGCEAMSPS------S 2784

Query: 3306 SPVPPGADVSDSSDDESIYQPVPVKKYTFKLK----------EVDDEQKEKPKASAEKAS 3355
            S  P  + +   + D+   QPV + K +  L+          E+D  + E P+A     S
Sbjct: 2785 SAAPVSSGLQSPTGDDVDEQPV-IYKESLALQGTHEKDTEGEELDVSRAESPQADCPSES 2843

Query: 3356 NQKE------LESNGSGKDNEFGLGLDSPQNEIAQNGNNDQSITECSIATTAEFSHDTDA 3409
                      L S G   D +        + E+ +     +++ +   +  +  +  TD 
Sbjct: 2844 FSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTDETFENLPKDCPSQDSSITTQTDR 2903

Query: 3410 TEIDSLDGYDLQDEDD----GLTESDSKLPIQAM----EIKKDIWNTEGILKPADRSFSQ 3461
              +D +   DL + D+     +T     +P Q+     E K            +   +S 
Sbjct: 2904 FSMD-VPVSDLAENDEIYDPQITSPYENVPSQSFFSSEESKTQTDANHTTSFHSSEVYSV 2962

Query: 3462 SKLEVIEEEGKVGPDEDKPPSKSSSSEKTPDKTDQKSGAQFFTLEGRHPDRSVFPDTYFS 3521
            +    +E+            SK S+ E    K + +  +  + ++      S  P    +
Sbjct: 2963 TITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQESTLWEMQSDSVSSSFEPTMSAT 3022

Query: 3522 YKVDEEFATPFKTVATK-GLDFDPWSNNRGDDEVFDSKSREDETKPFGLAVEDRSPATTP 3580
              V  E  +  K + TK  +D D WS  R DDE F+++ +E+E K FGL V+ +S  TTP
Sbjct: 3023 TTVVGEQIS--KVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGTTP 3080

Query: 3581 DTTPARTPTDESTPTSEPNPFPFHEGKMFEMTRSGAIDMSKRDFVEERLQFFQIG-EHTS 3639
            DTTPARTPT+E TPTSE NPF F EGK+FEMTRSGAIDM+KR + +E   FFQIG E   
Sbjct: 3081 DTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESRE 3140

Query: 3640 EGKSGDQGEGDKSMVTATPQPQSGDTTVETNLERNVETPTVEPNPSI---PTSGECQEGT 3696
            E  S D  EG      A P P   +T+ E +L  +    TV+    +     S E +E  
Sbjct: 3141 ETLSEDVKEG---ATGADPLPL--ETSAE-SLALSESKETVDDEADLLPDDVSEEVEEIP 3194

Query: 3697 SSSGSLEKSAAATNTSKVDPKLRTPIKMGISASTMTMKKEGPGEITDKIEAVMTSCQGLE 3756
            +S   L           +     TP K  +S  T  +     G+I         SC    
Sbjct: 3195 ASDAQLNSQMG------ISASTETPTKEAVSVGTKDLPTVQTGDIPPLSGVKQISCPDSS 3248

Query: 3757 NETITMISNTANSQMGVRPHEKHDFQKDNFNNNNNLDSSTIQTDNI-MSNIVLTEHSA-- 3813
               + +  + +     V      D   D+ +++     S I+     M N+  TE  +  
Sbjct: 3249 EPAVQVQLDFSTLTRSV----YSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFTESKSKI 3304

Query: 3814 PTCTTEKDNPVKVSSGKKTGVLQGHCVRDKQKVLGEQQKTKELIGIRQKSKLPIKA---- 3869
            P  T     P   S+  ++ V +     D    + E+ K  E    + KSKLP+K     
Sbjct: 3305 PVRTMPTSTPAPPSAEYESSVSE-----DFLSSVDEENKADE---AKPKSKLPVKVPLQR 3356

Query: 3870 ---------TSPKDTFPPNHMSNTKASKMKQVSQSEKTKALTTSSCVDVKSRIPVKNTHR 3920
                     TS + T  P      +   M  ++   ++K+ + +S +D K++ PVK    
Sbjct: 3357 VEQQLSDLDTSVQKTVAP------QGQDMASIAPDNRSKSESDASSLDSKTKCPVKTRSY 3410

Query: 3921 DNIIAVRKACATQKQGQPEKG--KAKQLPSKLPVKVRSTCVTTTTTTATTTTTTTTTTTT 3978
                   +  A + + + E+G  + K L S+LPVK RST  +    T+ T          
Sbjct: 3411 TETETESRERAEELELESEEGATRPKILTSRLPVKSRSTTSSCRGGTSPT---------- 3460

Query: 3979 SCTVKVRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSL 4038
                K  K    ++ ++SIE+F+ IS E  KLVDRL++ E++ Q  +SD+E S++   S+
Sbjct: 3461 ----KESKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSERE-QEIVSDDESSSALEVSV 3515

Query: 4039 SETSRGGQPSVTTKSARDKKTEAAPLKSKS-----EKAGSEKRSSRRTGPQSPCERTDIR 4093
             E      P  T  S  +   +  P+  +S     E+   E        PQ   ER + R
Sbjct: 3516 IENL---PPVETEHSVPEDIFDTRPIWDESIETLIERIPDENGHDHAEDPQDEQERIEER 3572

Query: 4094 MAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDA 4153
            +A +ADHLG SWTELAREL+F+ ++I+QIR+ENPNSL  QS  LLK W+ RDGK+AT   
Sbjct: 3573 LAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTN 3632

Query: 4154 LTSVLTKINRIDIVTLLE 4171
            L   LTKINR+DIV L+E
Sbjct: 3633 LVECLTKINRMDIVHLME 3650



 Score =  151 bits (381), Expect = 2e-35
 Identities = 432/2068 (20%), Positives = 725/2068 (35%), Gaps = 454/2068 (21%)

Query: 1897 SSQEILKDVAEMKEDLMRMTAILQTDVPEEKPF--QPELPKEGRIDDEEPFKIVEKVKED 1954
            +S ++L +V+EMK+DL++MTAIL TDV ++       EL K    +  EPF+IVE+VKED
Sbjct: 1499 ASPDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKED 1558

Query: 1955 LVKVSEILKKDVCVDNKGSPKSPKSDKGHSPEDDWIEFSSEEIREARQQA--AASQSPSL 2012
            L KV+EIL+   C  ++ S +S +S++G   E++W+  S EEI EARQ+A    ++ P +
Sbjct: 1559 LEKVNEILRSGTCTRDESSVQSSRSERG-LVEEEWVIVSDEEIEEARQKAPLEITEYPCV 1617

Query: 2013 PERVQVKAKAASEKDYNLTKVIDYLTNDIGS------SSLTNLKYKF------------- 2053
              R+  + K   EKD   T +++YLT+D+ +        L  ++ K              
Sbjct: 1618 EVRIDKEIKGKVEKD--STGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAVGRSS 1675

Query: 2054 ----EDAKKDGEERQKRVLKPAIALQ-------EHKLKMPPASMRTSTSEKELCK-MADS 2101
                +D   D  +  ++  KP++ ++       + K K     ++ S  + EL K  ++ 
Sbjct: 1676 EKEGKDIPPDETQSTQKQHKPSLGIKKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEE 1735

Query: 2102 FFGTD------------------------------TILESPDDFSQHDQDKSPLSDSGFE 2131
              G D                                L+   +  Q  + K P+   G E
Sbjct: 1736 SLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVKGKE 1795

Query: 2132 TRSEKTPSAPQSAE------------STGPKPLFHEV--------PIPPVITETRTEVVH 2171
               +KT   P  A             S  PK   H            PPV   ++TE   
Sbjct: 1796 DVPKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHS 1855

Query: 2172 VI------RSYDPSAGDVPQTQPEEPVSPKP--------SPTFMELEPKPTTSSIKEK-- 2215
             +        + P A    +T+   PVSP          S T  E  P  + S   +K  
Sbjct: 1856 PVSPSAKTERHSP-ASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRP 1914

Query: 2216 -------------------VKAFQMKASSEEDDHNRVLSKGMRVKEETHITTTTRMVYHS 2256
                                K   +  S   D H  V + G + ++   ++ + +     
Sbjct: 1915 PVSPSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAG-KTEKHLPVSPSGKTEKQP 1973

Query: 2257 PPGGEGASERIEETMSVHDIMKAFQSGRDPSKELAGLFEHKSAVSPDVHKSAAETSAQHA 2316
            P      +ERIEETMSV ++MKAFQSG+DPSK   GLFEHKSA                 
Sbjct: 1974 PVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSA----------------- 2016

Query: 2317 EKDNQMKPKLERIIEVHIEKG-----NQAEPTEVIIRETKKHPEKEMYVYQKDLSRGDIN 2371
                Q +P+ +  + V  EKG      +A+ TE    +T K  ++       +  RG + 
Sbjct: 2017 ---KQKQPQEKGKVRVEKEKGPILTQREAQKTE---NQTIKRGQRLPVTGTAESKRG-VR 2069

Query: 2372 LKDFLPEKHDAFPCSEEQGQQEEEELTAEESLPSYLESSRVNTPVSQEEDSRPSSAQLIS 2431
            +     +K DA            +E      +P  ++S      V +EE  R S      
Sbjct: 2070 VSSIGVKKEDA---------AGGKEKVLSHKIPEPVQS------VPEEESHRES------ 2108

Query: 2432 DDSYKTLKLLSQHSIEYHDDELSELRGESYRFAEKMLLSEKLDVSHSDTEESVTDHAGPP 2491
                           E   +++++ +G+             +D+  S   ++ TD +   
Sbjct: 2109 ---------------EVPKEKMADEQGD-------------MDLQISPDRKTSTDFSEVI 2140

Query: 2492 SSELQGSDKRSREKIATAPKKEILSKIYKDVSENGVGKVSKDEHFDKVTVLHYSGNVSSP 2551
              EL+ +DK  + +++   +K  L                   H D+V    +  N + P
Sbjct: 2141 KQELEDNDKYQQFRLSEETEKAQL-------------------HLDQVLTSPF--NTTFP 2179

Query: 2552 KHAMWMRF------TEDRLDRGREKLIYEDRVDRTVKEAEEKLTEVSQFFRDKTEKLNDE 2605
               M   F          LD   E L  E           E   ++S     K E L + 
Sbjct: 2180 LDYMKDEFLPALSLQSGALDGSSESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAET 2239

Query: 2606 LQ-SPEKKA-RPKNGKEYSSQSPTSSSPEKVLLTELLASNDE-WVKARQHGPDGQGFPKA 2662
             + SPE  +  PK  +E + ++  S+  E    TE+ +  +    K    G + +G    
Sbjct: 2240 PETSPESLSFSPKKSEEQTGETKESTKTETT--TEIRSEKEHPTTKDITGGSEERGATVT 2297

Query: 2663 EEKAPSLPSSPEKMVLSQQTEDS-KSTVEAKGSISQSKAPDGPQSGFQLKQSKLSSIRLK 2721
            E+   S  S  ++  L    + S K   +  GS S + A + P +G              
Sbjct: 2298 EDSETSTESFQKEATLGSPKDTSPKRQDDCTGSCSVALAKETP-TGL------------- 2343

Query: 2722 FEQGTHAKSKDMSQEDRKSDGQSRIPVKKIQESKLPVYQVFAREKQQKAIDLPDESV--- 2778
                T   + D  Q    S         ++QES        A   + KA+ LP+ SV   
Sbjct: 2344 ----TEEAACDEGQRTFGSSAHKTQTDSEVQEST-------ATSDETKALPLPEASVKTD 2392

Query: 2779 ------------SVQKDFMVLKTKDEHAQS----NEIVVNDSGSDNVKKQRTEMSSKAMP 2822
                        S Q   + L ++D    S    + + V+   S        + SS   P
Sbjct: 2393 TGTESKPQGVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEASPVLEDNSSHKTP 2452

Query: 2823 DSFSEQQAKDLACHITSDLATRGPWDKK-VFRTWESSGATNNKSQKEKLSHVLVHDVREN 2881
            DS      K+  C  + + +   P  K  +F +     A   K+  E L+ V    VR  
Sbjct: 2453 DSLEPSPLKESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKT--ELLTEVA--SVRSR 2508

Query: 2882 HIGHPESKSVDQKNEFMSVTERERKLLTNGSLSEIKEMT---------VKSPSKKVLYRE 2932
             +  P+  + D   E  S+ E   K   +      +E++         V +P   V++  
Sbjct: 2509 LLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDVSTPKPAVIHE- 2567

Query: 2933 YVVKEGDHPGGLLDQPSRRSESSAVSHIPVRVADERRMLSSNIPDGFCEQSAFPKHELSQ 2992
               +E D   G   + +   E   +    +++ DE    +    D   E    PK E S 
Sbjct: 2568 -CAEEDDSENGEKKRFTPEEEMFKMV-TKIKMFDELEQEAKQKRDYKKE----PKQEESS 2621

Query: 2993 KLS--QSSMSKETVETQHFNSIEDEK----VTYSEISKVSKHQSYVGLCPPLEETETSPT 3046
              S   +  S +  E +H  S EDE     +  SE  KVS           L++   S  
Sbjct: 2622 SSSDPDADCSVDVDEPKHTGSGEDESGVPVLVTSESRKVSSSSESEPELAQLKKGADSGL 2681

Query: 3047 KSPDSLEFSPGKESPSSDVFDHSPIDGLEKLAPLAQTEGGKEIKTLPVYVSFVQVGKQYE 3106
                 +   P    PSS   + SP                +E++  PV VS     K  E
Sbjct: 2682 LPEPVIRVQPPSPLPSSMDSNSSP----------------EEVQFQPV-VSKQYTFKMNE 2724

Query: 3107 KEIQQGGVKKIISQECKTVQETRGTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSGKSP 3166
               ++ G  +        + E R    T  + +           DT +Q    D  G   
Sbjct: 2725 DTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRS----YDKLNRDT-DQPKICDGHGCEA 2779

Query: 3167 LTPETPSSEEVSYEFTSKTPDSLIAYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEET 3226
            ++P + S+  VS    S T D            + E     +E    + T  K T  EE 
Sbjct: 2780 MSPSS-SAAPVSSGLQSPTGDD-----------VDEQPVIYKESLALQGTHEKDTEGEEL 2827

Query: 3227 AVEREMPNDVSKDSNQRPKNNRVAYIEFPPPPPLDAD-----------QIESDKKHHYLP 3275
             V R         S     ++ + +        LD D             ++D+    LP
Sbjct: 2828 DVSRAESPQADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTDETFENLP 2887

Query: 3276 EKEVDMIEVNLQDEHDKYQLAEPVIRVQPPSPVPPGADVSDSSDDESIYQPVPVKKYTFK 3335
             K+    + ++  + D++ +  P               VSD ++++ IY P     Y   
Sbjct: 2888 -KDCPSQDSSITTQTDRFSMDVP---------------VSDLAENDEIYDPQITSPY--- 2928

Query: 3336 LKEVDDEQKEKPKASAEKASNQKELESNGSGKDNE-FGLGLDSPQNEIAQNGNN------ 3388
                 +    +   S+E++  Q +     S   +E + + + SP  ++    ++      
Sbjct: 2929 -----ENVPSQSFFSSEESKTQTDANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTVLS 2983

Query: 3389 --------DQSITECSIATTAEFSHDTDATEIDSLDGYDLQDEDDGLTESDSKLPIQAME 3440
                    D  +     +T  E   D+ ++  +      +      + E  SK+ I   +
Sbjct: 2984 KESNFEGQDIKMESQQESTLWEMQSDSVSSSFEP----TMSATTTVVGEQISKVIITKTD 3039

Query: 3441 IKKDIWNTEGILKPADRSFSQSKLEVIEEEGKV----------GPDEDKPPSKSSSSEKT 3490
            +  D W+    ++  D +F   +  V EEE K+          G   D  P+++ + E T
Sbjct: 3040 VDSDSWSE---IREDDEAF---EARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGT 3093

Query: 3491 PDKTDQ----KSGAQFFTLEGRHPD---RSVFPDTYFSYKVDEEF--ATPFKTVATKGLD 3541
            P         + G  F        D   RS   +++  +++ +E    T  + V      
Sbjct: 3094 PTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREETLSEDVKEGATG 3153

Query: 3542 FDPWSNNRGDDEVFDSKSREDETKPFGLAVEDRS------PATTPD-------TTPARTP 3588
             DP       + +  S+S+E       L  +D S      PA+          +    TP
Sbjct: 3154 ADPLPLETSAESLALSESKETVDDEADLLPDDVSEEVEEIPASDAQLNSQMGISASTETP 3213

Query: 3589 TDEST-------PTSEPNPFPFHEGKMFEMTRSGAIDMSKRDFVEERLQFFQIGEHTSEG 3641
            T E+        PT +    P   G      +  +   S    V+ +L F  +       
Sbjct: 3214 TKEAVSVGTKDLPTVQTGDIPPLSG-----VKQISCPDSSEPAVQVQLDFSTLTRSVYSD 3268

Query: 3642 KSGD----QGEGDKSMVTATPQPQSGDTTVETNLERNVET-PTVEPNPSIPTSGECQEGT 3696
            +  D      E  KS++     P       E+  +  V T PT  P    P S E  E +
Sbjct: 3269 RGDDSPDSSPEEQKSVIEIPTAPMENVPFTESKSKIPVRTMPTSTP---APPSAE-YESS 3324

Query: 3697 SSSGSLEKSAAATNTSKVDPKLRTPIKM 3724
             S   L          +  PK + P+K+
Sbjct: 3325 VSEDFLSSVDEENKADEAKPKSKLPVKV 3352


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 2139 bits (5542), Expect = 0.0
 Identities = 1071/1469 (72%), Positives = 1240/1469 (84%), Gaps = 72/1469 (4%)

Query: 33   RDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSE 92
            R R KKSD+NAS+LRAARAG+L+K ++Y+K G+DIN CNQNGLNALHLA+KEGHV +V E
Sbjct: 23   RKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQE 82

Query: 93   LLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENH 152
            LL R ++VD+ATKKGNTALHIASLAGQAEVVKVLV  GAN+NAQSQNGFTPLYMAAQENH
Sbjct: 83   LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 142

Query: 153  LEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARK 212
            ++VVK+LL+NGA+QS ATEDGFTPLAVALQQGH+Q V++LLENDTKGKVRLPALHIAARK
Sbjct: 143  IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 202

Query: 213  DDTKAAALLLQNDNNADVESK--------SGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
            DDTK+AALLLQND+NADV+SK        SGFTPLHIAAHYGN+NVATLLLNR AAVDFT
Sbjct: 203  DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262

Query: 265  ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
            ARN ITPLHVASKRGN NMVKLLLDRG +IDAKTRDGLTPLHC ARSGH+QVVE+LL+R 
Sbjct: 263  ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG 322

Query: 325  APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAK 384
            AP+L++TKNGLSPLHMA QGDH+ CV+ LLQH  PVDDVT DYLTALHVAAHCGHY+V K
Sbjct: 323  APLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTK 382

Query: 385  VLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMG 444
            +LLDK+ANPNA+ALNGFTPLHIACKKNRIKVMELL+K+GASIQA+TESGLTPIHVAAFMG
Sbjct: 383  LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMG 442

Query: 445  HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLH 504
            H+NIV  L+ +GASP+ TN+RGETALHMAAR+GQ EVVR L+++GA V+A+A+++QTPLH
Sbjct: 443  HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLH 502

Query: 505  ISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKK 564
            I++RLGK +IVQ LLQ  A P+AATT+GYTPLH+SAREG  DVA+ LL+ GA+ S+ TKK
Sbjct: 503  IASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK 562

Query: 565  GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624
            GFTPLHVAAKYG L+VA LLLQ+ A+ D+AGK+GLTPLHVAAHYDNQKVALLLL++GASP
Sbjct: 563  GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622

Query: 625  HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 684
            HA AKNGYTPLHIAAKKNQM IA+TLL YGA+ N VT+QG+  +HLA+QEGH DMV+LLL
Sbjct: 623  HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682

Query: 685  GRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIK 744
             + AN+++S KSGLT LHLAAQED+VNVA++L   GA  DA TK+GYTPL V CHYGN+K
Sbjct: 683  DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742

Query: 745  IVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIAR 804
            +VNFLL+  A VNAKTKNGYTPLHQAAQQGHTHIINVLLQ+ A PN  T NGNTAL IA+
Sbjct: 743  MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802

Query: 805  RLGYISVVDTLKIVTEE-TMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDG 863
            RLGYISVVDTLK+VTEE T TTTT+TEKHK+NVPETM EVLD+SD               
Sbjct: 803  RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSD--------------- 847

Query: 864  EYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAE------GYMGFSL-GARSASLRS 916
                  EEG+D MTGD  +YL P+DLKELGDDSLP+        Y+ +SL G RS SLRS
Sbjct: 848  ------EEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRS 901

Query: 917  FSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLV 976
            FSSDRS+TL+ +SY RDS ++++ +V    Q  T  +E + +S R  SW  + LDNV L 
Sbjct: 902  FSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYR-LSWGTENLDNVALS 960

Query: 977  SSPIHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPM 1036
            SSPIHSGFLVSFMVDARGG+MRG RH+G+RIIIPPRKCTAPTR+TCRLVKRH+LA  PPM
Sbjct: 961  SSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPM 1020

Query: 1037 VEGEGLASRLVEMGPAGAQFLG---------------------------------PVIVE 1063
            VEGEGLASRL+E+GP+GAQFLG                                 PVIVE
Sbjct: 1021 VEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVE 1080

Query: 1064 IPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRIC 1123
            IPHF ++RGKEREL+VLRSENG++WKEH  D   ++L E+LNGMDE LDSPE+L KKRIC
Sbjct: 1081 IPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRIC 1140

Query: 1124 RIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQP 1183
            RIIT+DFPQYFAVVSRIKQ+SN IGPEGG+LSST VP VQA FPEGALTKRIRVGLQAQP
Sbjct: 1141 RIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQP 1200

Query: 1184 VPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLR 1243
            +  E+VKKILGNKATFSPIVT+EPRRRKFHKPITMTIPVP  S + + NG+ GD  P LR
Sbjct: 1201 MHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDA-PTLR 1259

Query: 1244 LLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYR 1303
            LLCSITGGT+PAQWEDITGTTPLTF+ +CVSFTTNVSARFWL DC Q+ E+V  A+Q+YR
Sbjct: 1260 LLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYR 1319

Query: 1304 ELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGK 1363
            E+ICVPYMAKFVVFAK +DP+E+ LRCFCMTDDKVDKTLEQQENF EVARS+D+EVLEGK
Sbjct: 1320 EIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGK 1379

Query: 1364 PIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKG 1423
            PIYVDC+GNL PLTK GQ  +F+F++FKENRLP  +K+RDT+QEPCGRLSF+KEPK+T+G
Sbjct: 1380 PIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRG 1439

Query: 1424 LPQTAVCNLNITLPAHKKETESDQDDEIE 1452
            L   A+CNLNITLP + KE+ESDQ+ E E
Sbjct: 1440 LVHQAICNLNITLPIYTKESESDQEQEEE 1468



 Score =  113 bits (282), Expect = 5e-24
 Identities = 58/113 (51%), Positives = 77/113 (68%), Gaps = 4/113 (3%)

Query: 4063 PLKSKSEKAGSEKRS----SRRTGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDE 4118
            P+ +K  ++  E+      +    PQ   ER + R+A +ADHLG SWTELAREL+F+ ++
Sbjct: 1453 PIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQ 1512

Query: 4119 INQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLE 4171
            I+QIR+ENPNSL  QS  LLK W+ RDGK+AT   L   LTKINR+DIV L+E
Sbjct: 1513 IHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME 1565


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 2125 bits (5507), Expect = 0.0
 Identities = 1068/1477 (72%), Positives = 1238/1477 (83%), Gaps = 84/1477 (5%)

Query: 37   KKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR 96
            +KSD+NAS+LRAARAG+L+K ++Y+K G+DIN CNQNGLNALHLA+KEGHV +V ELL R
Sbjct: 6    QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65

Query: 97   EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156
             ++VD+ATKKGNTALHIASLAGQAEVVKVLV  GAN+NAQSQNGFTPLYMAAQENH++VV
Sbjct: 66   GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125

Query: 157  KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTK 216
            K+LL+NGA+QS ATEDGFTPLAVALQQGH+Q V++LLENDTKGKVRLPALHIAARKDDTK
Sbjct: 126  KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185

Query: 217  AAALLLQNDNNADVESK--------SGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
            +AALLLQND+NADV+SK        SGFTPLHIAAHYGN+NVATLLLNR AAVDFTARN 
Sbjct: 186  SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245

Query: 269  ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
            ITPLHVASKRGN NMVKLLLDRG +IDAKTRDGLTPLHC ARSGH+QVVE+LL+R AP+L
Sbjct: 246  ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305

Query: 329  SKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLD 388
            ++TKNGLSPLHMA QGDH+ CV+ LLQH  PVDDVT DYLTALHVAAHCGHY+V K+LLD
Sbjct: 306  ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 365

Query: 389  KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448
            K+ANPNA+ALNGFTPLHIACKKNRIKVMELL+K+GASIQA+TESGLTPIHVAAFMGH+NI
Sbjct: 366  KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425

Query: 449  VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508
            V  L+ +GASP+ TN+RGETALHMAAR+GQ EVVR L+++GA V+A+A+++QTPLHI++R
Sbjct: 426  VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485

Query: 509  LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTP 568
            LGK +IVQ LLQ  A P+AATT+GYTPLH+SAREG  DVA+ LL+ GA+ S+ TKKGFTP
Sbjct: 486  LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545

Query: 569  LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
            LHVAAKYG L+VA LLLQ+ A+ D+AGK+GLTPLHVAAHYDNQKVALLLL++GASPHA A
Sbjct: 546  LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605

Query: 629  KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA 688
            KNGYTPLHIAAKKNQM IA+TLL YGA+ N VT+QG+  +HLA+QEGH DMV+LLL + A
Sbjct: 606  KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665

Query: 689  NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNF 748
            N+++S KSGLT LHLAAQED+VNVA++L   GA  DA TK+GYTPL V CHYGN+K+VNF
Sbjct: 666  NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725

Query: 749  LLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGY 808
            LL+  A VNAKTKNGYTPLHQAAQQGHTHIINVLLQ+ A PN  T NGNTAL IA+RLGY
Sbjct: 726  LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785

Query: 809  ISVVDTLKIVTEE-TMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYIS 867
            ISVVDTLK+VTEE T TTTT+TEKHK+NVPETM EVLD+SD                   
Sbjct: 786  ISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSD------------------- 826

Query: 868  DVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAE------GYMGFSL-GARSASLRSFSSD 920
              EEG+D MTGD  +YL P+DLKELGDDSLP+        Y+ +SL G RS SLRSFSSD
Sbjct: 827  --EEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSD 884

Query: 921  RSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPI 980
            RS+TL+ +SY RDS ++++ +V    Q  T  +E + +S R  SW  + LDNV L SSPI
Sbjct: 885  RSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYR-LSWGTENLDNVALSSSPI 943

Query: 981  HSG------------FLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRH 1028
            HSG            FLVSFMVDARGG+MRG RH+G+RIIIPPRKCTAPTR+TCRLVKRH
Sbjct: 944  HSGRASPCLERDNSSFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRH 1003

Query: 1029 KLANPPPMVEGEGLASRLVEMGPAGAQFLG------------------------------ 1058
            +LA  PPMVEGEGLASRL+E+GP+GAQFLG                              
Sbjct: 1004 RLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTK 1063

Query: 1059 ---PVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPE 1115
               PVIVEIPHF ++RGKEREL+VLRSENG++WKEH  D   ++L E+LNGMDE LDSPE
Sbjct: 1064 FLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPE 1123

Query: 1116 ELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRI 1175
            +L KKRICRIIT+DFPQYFAVVSRIKQ+SN IGPEGG+LSST VP VQA FPEGALTKRI
Sbjct: 1124 DLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRI 1183

Query: 1176 RVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYK 1235
            RVGLQAQP+  E+VKKILGNKATFSPIVT+EPRRRKFHKPITMTIPVP  S + + NG+ 
Sbjct: 1184 RVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFG 1243

Query: 1236 GDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETV 1295
            GD  P LRLLCSITGGT+PAQWEDITGTTPLTF+ +CVSFTTNVSARFWL DC Q+ E+V
Sbjct: 1244 GDA-PTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESV 1302

Query: 1296 GLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSK 1355
              A+Q+YRE+ICVPYMAKFVVFAK +DP+E+ LRCFCMTDDKVDKTLEQQENF EVARS+
Sbjct: 1303 TFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSR 1362

Query: 1356 DIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFL 1415
            D+EVLEGKPIYVDC+GNL PLTK GQ  +F+F++FKENRLP  +K+RDT+QEPCGRLSF+
Sbjct: 1363 DVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFM 1422

Query: 1416 KEPKTTKGLPQTAVCNLNITLPAHKKETESDQDDEIE 1452
            KEPK+T+GL   A+CNLNITLP + KE+ESDQ+ E E
Sbjct: 1423 KEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEE 1459



 Score =  113 bits (282), Expect = 5e-24
 Identities = 58/113 (51%), Positives = 77/113 (68%), Gaps = 4/113 (3%)

Query: 4063 PLKSKSEKAGSEKRS----SRRTGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDE 4118
            P+ +K  ++  E+      +    PQ   ER + R+A +ADHLG SWTELAREL+F+ ++
Sbjct: 1444 PIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQ 1503

Query: 4119 INQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLE 4171
            I+QIR+ENPNSL  QS  LLK W+ RDGK+AT   L   LTKINR+DIV L+E
Sbjct: 1504 IHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME 1556


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 1784 bits (4620), Expect = 0.0
 Identities = 913/1484 (61%), Positives = 1127/1484 (75%), Gaps = 52/1484 (3%)

Query: 1    MAHAASQLKKNRDLEINA----EEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEK 56
            MA AA QLKK +D+E  A    +E+ E  RK R RSRDRKKK+DA  S+LRAAR+G+L+K
Sbjct: 1    MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDK 60

Query: 57   ALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASL 116
            ALD+++NGVDIN CNQNGLN LHLASKEGHV++V ELL +E  ++  TKKGNTALHIA+L
Sbjct: 61   ALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAAL 120

Query: 117  AGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTP 176
            AGQ EVV+ LV  GANVNAQSQ GFTPLYMAAQENHLEVVKFLL+NGA+Q++ATEDGFTP
Sbjct: 121  AGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 180

Query: 177  LAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGF 236
            LAVALQQGH+ VV+ L+   TKGKVRLPALHIAAR DDT+ AA+LLQND N DV SK+GF
Sbjct: 181  LAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGF 240

Query: 237  TPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDA 296
            TPLHIAAHY N+NVA LLLNR A+V+FT +N ITPLH+AS+RGN  MV+LLLDRGA+I+ 
Sbjct: 241  TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 300

Query: 297  KTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH 356
            KT+D LTPLHC AR+GH ++ E+LLD  API +KTKNGLSP+HMA QGDHL+CV+LLLQ+
Sbjct: 301  KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 360

Query: 357  NVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVM 416
            +  +DD+T D+LT LHVAAHCGH++VAKVLLDK A PN++ALNGFTPLHIACKKN ++VM
Sbjct: 361  DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 420

Query: 417  ELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARS 476
            ELLLK GASI AVTESGLTP+HVA+FMGH+ IV  L+  GASPN +NV+ ET LHMAAR+
Sbjct: 421  ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 480

Query: 477  GQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPL 536
            G  EV +YL+Q+ A+V AKAKDDQTPLH +AR+G  ++V+ LL+  A+PN ATT+G+TPL
Sbjct: 481  GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540

Query: 537  HLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGK 596
            H++AREGH +    LL+  AS +  TKKGFTPLHVAAKYGK+ VA LLL++ A P+AAGK
Sbjct: 541  HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 600

Query: 597  SGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD 656
            +GLTPLHVA H++N  +  LLL +G SPH+ A NGYTPLHIAAK+NQ+++A +LL+YG  
Sbjct: 601  NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 660

Query: 657  ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716
            ANA + QG+  +HLAAQEGH +MV+LLL + AN NL NKSGLTPLHL AQE  V VA+VL
Sbjct: 661  ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 720

Query: 717  VNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHT 776
            +  G  VDA T+MGYTPLHV  HYGNIK+V FLLQH A VNAKTK GY+PLHQAAQQGHT
Sbjct: 721  IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 780

Query: 777  HIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNV 836
             I+ +LL+N ASPNE++ +G T L IA+RLGYISV D LK+VT+ET +   V++KH+M+ 
Sbjct: 781  DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDET-SFVLVSDKHRMSF 839

Query: 837  PETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKELGDDS 896
            PET++E+LD+S+DE     A   +   E IS   E  D+   D +K              
Sbjct: 840  PETVDEILDVSEDE---GTAHITIMGEELISFKAERRDSRDVDEEK-------------- 882

Query: 897  LPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFD 956
                             L  F       +   +  R    + E +V   E+    ++E+D
Sbjct: 883  ----------------ELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYD 926

Query: 957  SDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTA 1016
             DSL   S A +T DN++ V+SP+H+GFLVSFMVDARGGSMRGSRH+G+R++IPPR C A
Sbjct: 927  EDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAA 986

Query: 1017 PTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERE 1076
            PTRITCRLVK  KL+ PPP+ E EGLASR++ +GP GAQFL PVIVEIPHF S    +RE
Sbjct: 987  PTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRE 1046

Query: 1077 LIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDFPQYFAV 1136
            L+VLRSENG  WKEH+       L ++LNGMDEEL S EEL KKR+CRIIT DFP YF +
Sbjct: 1047 LVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVI 1106

Query: 1137 VSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGNK 1196
            +SR+ Q+ + IGPEGG L S  VPLVQA+FPE A+TKR+++ LQAQPVPDE+V K+LGN+
Sbjct: 1107 MSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQ 1166

Query: 1197 ATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQ 1256
            ATFSPIVTVEPRRRKFH+PI + IP+PP   +   +  +GDTT +LRLLCS+ GGT  AQ
Sbjct: 1167 ATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTT-SLRLLCSVIGGTDQAQ 1225

Query: 1257 WEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPYMAKFVV 1316
            WEDITGTT L +  +C +FTTNVSARFWL+DC +  E V  AT LY+EL  VPYMAKFV+
Sbjct: 1226 WEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVI 1285

Query: 1317 FAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPL 1376
            FAKMNDP E  LRC+CMTDDKVDKTLEQ ENF EVARS+DIEVLEG  ++ +  GNL P+
Sbjct: 1286 FAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPV 1345

Query: 1377 TKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITL 1436
             K  QQ  F+F SF+ENRL   +K+RD+S+EP G LSFL++    +   Q  +C+LNIT+
Sbjct: 1346 KKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYED-TQHILCHLNITM 1404

Query: 1437 PAHKKETESDQDDEIEKTDRRQSFASLALRKRYSYLTE--PGMI 1478
            P   K + ++        DRR++   LAL  RYS L+E  PG +
Sbjct: 1405 PPCAKGSGAE--------DRRRTPTPLAL--RYSILSESTPGSL 1438



 Score =  107 bits (268), Expect = 2e-22
 Identities = 59/144 (40%), Positives = 83/144 (57%), Gaps = 5/144 (3%)

Query: 4047 PSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDIRMAIVADHLGLSWT 4106
            P      A D++    PL  +         S    G  S  E+ +++MA++++HLGLSW 
Sbjct: 1406 PCAKGSGAEDRRRTPTPLALRYSIL-----SESTPGSLSGTEQAEMKMAVISEHLGLSWA 1460

Query: 4107 ELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDI 4166
            ELAREL FSV++IN+IRVENPNSL+ QS  LL  WV R+G+NA  + L + L  I+R +I
Sbjct: 1461 ELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEI 1520

Query: 4167 VTLLEGPIFDYGNISGTRSFADEN 4190
            V +LEG      N+   R   D +
Sbjct: 1521 VNMLEGSGRQSRNLKPDRRHTDRD 1544


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 1743 bits (4514), Expect = 0.0
 Identities = 888/1444 (61%), Positives = 1099/1444 (76%), Gaps = 56/1444 (3%)

Query: 37   KKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR 96
            +++DA  S+LRAAR+G+L+KALD+++NGVDIN CNQNGLN LHLASKEGHV++V ELL +
Sbjct: 8    READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 97   EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156
            E  ++  TKKGNTALHIA+LAGQ EVV+ LV  GANVNAQSQ GFTPLYMAAQENHLEVV
Sbjct: 68   EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 157  KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTK 216
            KFLL+NGA+Q++ATEDGFTPLAVALQQGH+ VV+ L+   TKGKVRLPALHIAAR DDT+
Sbjct: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187

Query: 217  AAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVAS 276
             AA+LLQND N DV SK+GFTPLHIAAHY N+NVA LLLNR A+V+FT +N ITPLH+AS
Sbjct: 188  TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 277  KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS 336
            +RGN  MV+LLLDRGA+I+ KT+D LTPLHC AR+GH ++ E+LLD  API +KTKNGLS
Sbjct: 248  RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 337  PLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK 396
            P+HMA QGDHL+CV+LLLQ++  +DD+T D+LT LHVAAHCGH++VAKVLLDK A PN++
Sbjct: 308  PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367

Query: 397  ALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 456
            ALNGFTPLHIACKKN ++VMELLLK GASI AVTESGLTP+HVA+FMGH+ IV  L+  G
Sbjct: 368  ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 457  ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQ 516
            ASPN +NV+ ET LHMAAR+G  EV +YL+Q+ A+V AKAKDDQTPLH +AR+G  ++V+
Sbjct: 428  ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487

Query: 517  QLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYG 576
             LL+  A+PN ATT+G+TPLH++AREGH +    LL+  AS +  TKKGFTPLHVAAKYG
Sbjct: 488  LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547

Query: 577  KLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLH 636
            K+ VA LLL++ A P+AAGK+GLTPLHVA H++N  +  LLL +G SPH+ A NGYTPLH
Sbjct: 548  KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607

Query: 637  IAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS 696
            IAAK+NQ+++A +LL+YG  ANA + QG+  +HLAAQEGH +MV+LLL + AN NL NKS
Sbjct: 608  IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667

Query: 697  GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKV 756
            GLTPLHL AQE  V VA+VL+  G  VDA T+MGYTPLHV  HYGNIK+V FLLQH A V
Sbjct: 668  GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727

Query: 757  NAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLK 816
            NAKTK GY+PLHQAAQQGHT I+ +LL+N ASPNE++ +G T L IA+RLGYISV D LK
Sbjct: 728  NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787

Query: 817  IVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAM 876
            +VT+ET +   V++KH+M+ PET++E+LD+S+DE             E IS   E  D+ 
Sbjct: 788  VVTDET-SFVLVSDKHRMSFPETVDEILDVSEDE-----------GEELISFKAERRDSR 835

Query: 877  TGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMM 936
              D +K                               L  F       +   +  R    
Sbjct: 836  DVDEEK------------------------------ELLDFVPKLDQVVESPAIPRIPCA 865

Query: 937  IEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGS 996
            + E +V   E+    ++E+D DSL   S A +T DN++ V+SP+H+GFLVSFMVDARGGS
Sbjct: 866  MPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGS 925

Query: 997  MRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQF 1056
            MRGSRH+G+R++IPPR C APTRITCRLVK  KL+ PPP+ E EGLASR++ +GP GAQF
Sbjct: 926  MRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQF 985

Query: 1057 LGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEE 1116
            L PVIVEIPHF S    +REL+VLRSENG  WKEH+       L ++LNGMDEEL S EE
Sbjct: 986  LSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEE 1045

Query: 1117 LGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIR 1176
            L KKR+CRIIT DFP YF ++SR+ Q+ + IGPEGG L S  VPLVQA+FPE A+TKR++
Sbjct: 1046 LEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVK 1105

Query: 1177 VGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKG 1236
            + LQAQPVPDE+V K+LGN+ATFSPIVTVEPRRRKFH+PI + IP+PP   +   +  +G
Sbjct: 1106 LALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEG 1165

Query: 1237 DTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVG 1296
            DTT +LRLLCS+ GGT  AQWEDITGTT L +  +C +FTTNVSARFWL+DC +  E V 
Sbjct: 1166 DTT-SLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVN 1224

Query: 1297 LATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKD 1356
             AT LY+EL  VPYMAKFV+FAKMNDP E  LRC+CMTDDKVDKTLEQ ENF EVARS+D
Sbjct: 1225 FATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRD 1284

Query: 1357 IEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLK 1416
            IEVLEG  ++ +  GNL P+ K  QQ  F+F SF+ENRL   +K+RD+S+EP G LSFL+
Sbjct: 1285 IEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLR 1344

Query: 1417 EPKTTKGLPQTAVCNLNITLPAHKKETESDQDDEIEKTDRRQSFASLALRKRYSYLTE-- 1474
            +    +   Q  +C+LNIT+P   K + ++        DRR++   LAL  RYS L+E  
Sbjct: 1345 KAMKYED-TQHILCHLNITMPPCAKGSGAE--------DRRRTPTPLAL--RYSILSEST 1393

Query: 1475 PGMI 1478
            PG +
Sbjct: 1394 PGSL 1397



 Score =  339 bits (870), Expect = 3e-92
 Identities = 213/618 (34%), Positives = 307/618 (49%), Gaps = 62/618 (10%)

Query: 260 AVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEM 319
           +V F   +  T    A++ GN +     L  G  I+   ++GL  LH  ++ GH ++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 320 LLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGH 379
           LL +   + + TK G + LH+A        V+ L+ +   V+  +    T L++AA   H
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 380 YKVAKVLLDKKANPNAKALNGFTPL-----------------------------HIACKK 410
            +V K LL+  AN N    +GFTPL                             HIA + 
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 411 NRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETAL 470
           +  +   +LL++  +   ++++G TP+H+AA   ++N+   L++ GAS N T   G T L
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243

Query: 471 HMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATT 530
           H+A+R G   +VR L+  GAQ+E K KD+ TPLH +AR G   I + LL  GA   A T 
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303

Query: 531 SG---------------------------------YTPLHLSAREGHEDVAAFLLDHGAS 557
           +G                                  TPLH++A  GH  VA  LLD GA 
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
            +     GFTPLH+A K   + V  LLL+  AS DA  +SGLTPLHVA+   +  +   L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV 677
           L +GASP+ +     TPLH+AA+    ++A  LL+  A  NA  +     +H AA+ GH 
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483

Query: 678 DMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG 737
           +MV LLL  NAN NL+  +G TPLH+AA+E  V     L+ + A     TK G+TPLHV 
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543

Query: 738 CHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN 797
             YG +++   LL+  A  NA  KNG TPLH A    +  I+ +LL    SP+    NG 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 798 TALGIARRLGYISVVDTL 815
           T L IA +   + V  +L
Sbjct: 604 TPLHIAAKQNQVEVARSL 621



 Score =  211 bits (538), Expect = 1e-53
 Identities = 118/329 (35%), Positives = 181/329 (55%), Gaps = 4/329 (1%)

Query: 29  RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88
           + +++   K  D       AAR GH       ++N  + N+    G   LH+A++EGHVE
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517

Query: 89  VVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA 148
            V  LL++EA+    TKKG T LH+A+  G+  V ++L+   A+ NA  +NG TPL++A 
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577

Query: 149 QENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVR----LP 204
             N+L++VK LL  G S      +G+TPL +A +Q   +V   LL+            + 
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637

Query: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
            LH+AA++   +  ALLL    N ++ +KSG TPLH+ A  G++ VA +L+     VD T
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697

Query: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
            R   TPLHVAS  GN  +VK LL   A ++AKT+ G +PLH  A+ GH  +V +LL   
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757

Query: 325 APILSKTKNGLSPLHMATQGDHLNCVQLL 353
           A     + +G +PL +A +  +++   +L
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  107 bits (268), Expect = 2e-22
 Identities = 59/144 (40%), Positives = 83/144 (57%), Gaps = 5/144 (3%)

Query: 4047 PSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDIRMAIVADHLGLSWT 4106
            P      A D++    PL  +         S    G  S  E+ +++MA++++HLGLSW 
Sbjct: 1365 PCAKGSGAEDRRRTPTPLALRYSIL-----SESTPGSLSGTEQAEMKMAVISEHLGLSWA 1419

Query: 4107 ELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDI 4166
            ELAREL FSV++IN+IRVENPNSL+ QS  LL  WV R+G+NA  + L + L  I+R +I
Sbjct: 1420 ELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEI 1479

Query: 4167 VTLLEGPIFDYGNISGTRSFADEN 4190
            V +LEG      N+   R   D +
Sbjct: 1480 VNMLEGSGRQSRNLKPDRRHTDRD 1503


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 1743 bits (4514), Expect = 0.0
 Identities = 888/1444 (61%), Positives = 1099/1444 (76%), Gaps = 56/1444 (3%)

Query: 37   KKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR 96
            +++DA  S+LRAAR+G+L+KALD+++NGVDIN CNQNGLN LHLASKEGHV++V ELL +
Sbjct: 8    READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 97   EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156
            E  ++  TKKGNTALHIA+LAGQ EVV+ LV  GANVNAQSQ GFTPLYMAAQENHLEVV
Sbjct: 68   EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 157  KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTK 216
            KFLL+NGA+Q++ATEDGFTPLAVALQQGH+ VV+ L+   TKGKVRLPALHIAAR DDT+
Sbjct: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187

Query: 217  AAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVAS 276
             AA+LLQND N DV SK+GFTPLHIAAHY N+NVA LLLNR A+V+FT +N ITPLH+AS
Sbjct: 188  TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 277  KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS 336
            +RGN  MV+LLLDRGA+I+ KT+D LTPLHC AR+GH ++ E+LLD  API +KTKNGLS
Sbjct: 248  RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 337  PLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK 396
            P+HMA QGDHL+CV+LLLQ++  +DD+T D+LT LHVAAHCGH++VAKVLLDK A PN++
Sbjct: 308  PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367

Query: 397  ALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 456
            ALNGFTPLHIACKKN ++VMELLLK GASI AVTESGLTP+HVA+FMGH+ IV  L+  G
Sbjct: 368  ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 457  ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQ 516
            ASPN +NV+ ET LHMAAR+G  EV +YL+Q+ A+V AKAKDDQTPLH +AR+G  ++V+
Sbjct: 428  ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487

Query: 517  QLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYG 576
             LL+  A+PN ATT+G+TPLH++AREGH +    LL+  AS +  TKKGFTPLHVAAKYG
Sbjct: 488  LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547

Query: 577  KLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLH 636
            K+ VA LLL++ A P+AAGK+GLTPLHVA H++N  +  LLL +G SPH+ A NGYTPLH
Sbjct: 548  KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607

Query: 637  IAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS 696
            IAAK+NQ+++A +LL+YG  ANA + QG+  +HLAAQEGH +MV+LLL + AN NL NKS
Sbjct: 608  IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667

Query: 697  GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKV 756
            GLTPLHL AQE  V VA+VL+  G  VDA T+MGYTPLHV  HYGNIK+V FLLQH A V
Sbjct: 668  GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727

Query: 757  NAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLK 816
            NAKTK GY+PLHQAAQQGHT I+ +LL+N ASPNE++ +G T L IA+RLGYISV D LK
Sbjct: 728  NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787

Query: 817  IVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAM 876
            +VT+ET +   V++KH+M+ PET++E+LD+S+DE             E IS   E  D+ 
Sbjct: 788  VVTDET-SFVLVSDKHRMSFPETVDEILDVSEDE-----------GEELISFKAERRDSR 835

Query: 877  TGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMM 936
              D +K                               L  F       +   +  R    
Sbjct: 836  DVDEEK------------------------------ELLDFVPKLDQVVESPAIPRIPCA 865

Query: 937  IEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGS 996
            + E +V   E+    ++E+D DSL   S A +T DN++ V+SP+H+GFLVSFMVDARGGS
Sbjct: 866  MPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGS 925

Query: 997  MRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQF 1056
            MRGSRH+G+R++IPPR C APTRITCRLVK  KL+ PPP+ E EGLASR++ +GP GAQF
Sbjct: 926  MRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQF 985

Query: 1057 LGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEE 1116
            L PVIVEIPHF S    +REL+VLRSENG  WKEH+       L ++LNGMDEEL S EE
Sbjct: 986  LSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEE 1045

Query: 1117 LGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIR 1176
            L KKR+CRIIT DFP YF ++SR+ Q+ + IGPEGG L S  VPLVQA+FPE A+TKR++
Sbjct: 1046 LEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVK 1105

Query: 1177 VGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKG 1236
            + LQAQPVPDE+V K+LGN+ATFSPIVTVEPRRRKFH+PI + IP+PP   +   +  +G
Sbjct: 1106 LALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEG 1165

Query: 1237 DTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVG 1296
            DTT +LRLLCS+ GGT  AQWEDITGTT L +  +C +FTTNVSARFWL+DC +  E V 
Sbjct: 1166 DTT-SLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVN 1224

Query: 1297 LATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKD 1356
             AT LY+EL  VPYMAKFV+FAKMNDP E  LRC+CMTDDKVDKTLEQ ENF EVARS+D
Sbjct: 1225 FATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRD 1284

Query: 1357 IEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLK 1416
            IEVLEG  ++ +  GNL P+ K  QQ  F+F SF+ENRL   +K+RD+S+EP G LSFL+
Sbjct: 1285 IEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLR 1344

Query: 1417 EPKTTKGLPQTAVCNLNITLPAHKKETESDQDDEIEKTDRRQSFASLALRKRYSYLTE-- 1474
            +    +   Q  +C+LNIT+P   K + ++        DRR++   LAL  RYS L+E  
Sbjct: 1345 KAMKYED-TQHILCHLNITMPPCAKGSGAE--------DRRRTPTPLAL--RYSILSEST 1393

Query: 1475 PGMI 1478
            PG +
Sbjct: 1394 PGSL 1397



 Score =  339 bits (870), Expect = 3e-92
 Identities = 213/618 (34%), Positives = 307/618 (49%), Gaps = 62/618 (10%)

Query: 260 AVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEM 319
           +V F   +  T    A++ GN +     L  G  I+   ++GL  LH  ++ GH ++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 320 LLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGH 379
           LL +   + + TK G + LH+A        V+ L+ +   V+  +    T L++AA   H
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 380 YKVAKVLLDKKANPNAKALNGFTPL-----------------------------HIACKK 410
            +V K LL+  AN N    +GFTPL                             HIA + 
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 411 NRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETAL 470
           +  +   +LL++  +   ++++G TP+H+AA   ++N+   L++ GAS N T   G T L
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243

Query: 471 HMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATT 530
           H+A+R G   +VR L+  GAQ+E K KD+ TPLH +AR G   I + LL  GA   A T 
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303

Query: 531 SG---------------------------------YTPLHLSAREGHEDVAAFLLDHGAS 557
           +G                                  TPLH++A  GH  VA  LLD GA 
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
            +     GFTPLH+A K   + V  LLL+  AS DA  +SGLTPLHVA+   +  +   L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV 677
           L +GASP+ +     TPLH+AA+    ++A  LL+  A  NA  +     +H AA+ GH 
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483

Query: 678 DMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG 737
           +MV LLL  NAN NL+  +G TPLH+AA+E  V     L+ + A     TK G+TPLHV 
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543

Query: 738 CHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN 797
             YG +++   LL+  A  NA  KNG TPLH A    +  I+ +LL    SP+    NG 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 798 TALGIARRLGYISVVDTL 815
           T L IA +   + V  +L
Sbjct: 604 TPLHIAAKQNQVEVARSL 621



 Score =  211 bits (538), Expect = 1e-53
 Identities = 118/329 (35%), Positives = 181/329 (55%), Gaps = 4/329 (1%)

Query: 29  RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88
           + +++   K  D       AAR GH       ++N  + N+    G   LH+A++EGHVE
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517

Query: 89  VVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA 148
            V  LL++EA+    TKKG T LH+A+  G+  V ++L+   A+ NA  +NG TPL++A 
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577

Query: 149 QENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVR----LP 204
             N+L++VK LL  G S      +G+TPL +A +Q   +V   LL+            + 
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637

Query: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
            LH+AA++   +  ALLL    N ++ +KSG TPLH+ A  G++ VA +L+     VD T
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697

Query: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
            R   TPLHVAS  GN  +VK LL   A ++AKT+ G +PLH  A+ GH  +V +LL   
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757

Query: 325 APILSKTKNGLSPLHMATQGDHLNCVQLL 353
           A     + +G +PL +A +  +++   +L
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  107 bits (268), Expect = 2e-22
 Identities = 59/144 (40%), Positives = 83/144 (57%), Gaps = 5/144 (3%)

Query: 4047 PSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDIRMAIVADHLGLSWT 4106
            P      A D++    PL  +         S    G  S  E+ +++MA++++HLGLSW 
Sbjct: 1365 PCAKGSGAEDRRRTPTPLALRYSIL-----SESTPGSLSGTEQAEMKMAVISEHLGLSWA 1419

Query: 4107 ELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDI 4166
            ELAREL FSV++IN+IRVENPNSL+ QS  LL  WV R+G+NA  + L + L  I+R +I
Sbjct: 1420 ELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEI 1479

Query: 4167 VTLLEGPIFDYGNISGTRSFADEN 4190
            V +LEG      N+   R   D +
Sbjct: 1480 VNMLEGSGRQSRNLKPDRRHTDRD 1503


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 1743 bits (4514), Expect = 0.0
 Identities = 888/1444 (61%), Positives = 1099/1444 (76%), Gaps = 56/1444 (3%)

Query: 37   KKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR 96
            +++DA  S+LRAAR+G+L+KALD+++NGVDIN CNQNGLN LHLASKEGHV++V ELL +
Sbjct: 8    READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 97   EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156
            E  ++  TKKGNTALHIA+LAGQ EVV+ LV  GANVNAQSQ GFTPLYMAAQENHLEVV
Sbjct: 68   EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 157  KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTK 216
            KFLL+NGA+Q++ATEDGFTPLAVALQQGH+ VV+ L+   TKGKVRLPALHIAAR DDT+
Sbjct: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187

Query: 217  AAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVAS 276
             AA+LLQND N DV SK+GFTPLHIAAHY N+NVA LLLNR A+V+FT +N ITPLH+AS
Sbjct: 188  TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 277  KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS 336
            +RGN  MV+LLLDRGA+I+ KT+D LTPLHC AR+GH ++ E+LLD  API +KTKNGLS
Sbjct: 248  RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 337  PLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK 396
            P+HMA QGDHL+CV+LLLQ++  +DD+T D+LT LHVAAHCGH++VAKVLLDK A PN++
Sbjct: 308  PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367

Query: 397  ALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 456
            ALNGFTPLHIACKKN ++VMELLLK GASI AVTESGLTP+HVA+FMGH+ IV  L+  G
Sbjct: 368  ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 457  ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQ 516
            ASPN +NV+ ET LHMAAR+G  EV +YL+Q+ A+V AKAKDDQTPLH +AR+G  ++V+
Sbjct: 428  ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487

Query: 517  QLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYG 576
             LL+  A+PN ATT+G+TPLH++AREGH +    LL+  AS +  TKKGFTPLHVAAKYG
Sbjct: 488  LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547

Query: 577  KLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLH 636
            K+ VA LLL++ A P+AAGK+GLTPLHVA H++N  +  LLL +G SPH+ A NGYTPLH
Sbjct: 548  KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607

Query: 637  IAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS 696
            IAAK+NQ+++A +LL+YG  ANA + QG+  +HLAAQEGH +MV+LLL + AN NL NKS
Sbjct: 608  IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667

Query: 697  GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKV 756
            GLTPLHL AQE  V VA+VL+  G  VDA T+MGYTPLHV  HYGNIK+V FLLQH A V
Sbjct: 668  GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727

Query: 757  NAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLK 816
            NAKTK GY+PLHQAAQQGHT I+ +LL+N ASPNE++ +G T L IA+RLGYISV D LK
Sbjct: 728  NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787

Query: 817  IVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAM 876
            +VT+ET +   V++KH+M+ PET++E+LD+S+DE             E IS   E  D+ 
Sbjct: 788  VVTDET-SFVLVSDKHRMSFPETVDEILDVSEDE-----------GEELISFKAERRDSR 835

Query: 877  TGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMM 936
              D +K                               L  F       +   +  R    
Sbjct: 836  DVDEEK------------------------------ELLDFVPKLDQVVESPAIPRIPCA 865

Query: 937  IEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGS 996
            + E +V   E+    ++E+D DSL   S A +T DN++ V+SP+H+GFLVSFMVDARGGS
Sbjct: 866  MPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGS 925

Query: 997  MRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQF 1056
            MRGSRH+G+R++IPPR C APTRITCRLVK  KL+ PPP+ E EGLASR++ +GP GAQF
Sbjct: 926  MRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQF 985

Query: 1057 LGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEE 1116
            L PVIVEIPHF S    +REL+VLRSENG  WKEH+       L ++LNGMDEEL S EE
Sbjct: 986  LSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEE 1045

Query: 1117 LGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIR 1176
            L KKR+CRIIT DFP YF ++SR+ Q+ + IGPEGG L S  VPLVQA+FPE A+TKR++
Sbjct: 1046 LEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVK 1105

Query: 1177 VGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKG 1236
            + LQAQPVPDE+V K+LGN+ATFSPIVTVEPRRRKFH+PI + IP+PP   +   +  +G
Sbjct: 1106 LALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEG 1165

Query: 1237 DTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVG 1296
            DTT +LRLLCS+ GGT  AQWEDITGTT L +  +C +FTTNVSARFWL+DC +  E V 
Sbjct: 1166 DTT-SLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVN 1224

Query: 1297 LATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKD 1356
             AT LY+EL  VPYMAKFV+FAKMNDP E  LRC+CMTDDKVDKTLEQ ENF EVARS+D
Sbjct: 1225 FATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRD 1284

Query: 1357 IEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLK 1416
            IEVLEG  ++ +  GNL P+ K  QQ  F+F SF+ENRL   +K+RD+S+EP G LSFL+
Sbjct: 1285 IEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLR 1344

Query: 1417 EPKTTKGLPQTAVCNLNITLPAHKKETESDQDDEIEKTDRRQSFASLALRKRYSYLTE-- 1474
            +    +   Q  +C+LNIT+P   K + ++        DRR++   LAL  RYS L+E  
Sbjct: 1345 KAMKYED-TQHILCHLNITMPPCAKGSGAE--------DRRRTPTPLAL--RYSILSEST 1393

Query: 1475 PGMI 1478
            PG +
Sbjct: 1394 PGSL 1397



 Score =  339 bits (870), Expect = 3e-92
 Identities = 213/618 (34%), Positives = 307/618 (49%), Gaps = 62/618 (10%)

Query: 260 AVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEM 319
           +V F   +  T    A++ GN +     L  G  I+   ++GL  LH  ++ GH ++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 320 LLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGH 379
           LL +   + + TK G + LH+A        V+ L+ +   V+  +    T L++AA   H
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 380 YKVAKVLLDKKANPNAKALNGFTPL-----------------------------HIACKK 410
            +V K LL+  AN N    +GFTPL                             HIA + 
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 411 NRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETAL 470
           +  +   +LL++  +   ++++G TP+H+AA   ++N+   L++ GAS N T   G T L
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243

Query: 471 HMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATT 530
           H+A+R G   +VR L+  GAQ+E K KD+ TPLH +AR G   I + LL  GA   A T 
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303

Query: 531 SG---------------------------------YTPLHLSAREGHEDVAAFLLDHGAS 557
           +G                                  TPLH++A  GH  VA  LLD GA 
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
            +     GFTPLH+A K   + V  LLL+  AS DA  +SGLTPLHVA+   +  +   L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV 677
           L +GASP+ +     TPLH+AA+    ++A  LL+  A  NA  +     +H AA+ GH 
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483

Query: 678 DMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG 737
           +MV LLL  NAN NL+  +G TPLH+AA+E  V     L+ + A     TK G+TPLHV 
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543

Query: 738 CHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN 797
             YG +++   LL+  A  NA  KNG TPLH A    +  I+ +LL    SP+    NG 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 798 TALGIARRLGYISVVDTL 815
           T L IA +   + V  +L
Sbjct: 604 TPLHIAAKQNQVEVARSL 621



 Score =  211 bits (538), Expect = 1e-53
 Identities = 118/329 (35%), Positives = 181/329 (55%), Gaps = 4/329 (1%)

Query: 29  RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88
           + +++   K  D       AAR GH       ++N  + N+    G   LH+A++EGHVE
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517

Query: 89  VVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA 148
            V  LL++EA+    TKKG T LH+A+  G+  V ++L+   A+ NA  +NG TPL++A 
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577

Query: 149 QENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVR----LP 204
             N+L++VK LL  G S      +G+TPL +A +Q   +V   LL+            + 
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637

Query: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
            LH+AA++   +  ALLL    N ++ +KSG TPLH+ A  G++ VA +L+     VD T
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697

Query: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
            R   TPLHVAS  GN  +VK LL   A ++AKT+ G +PLH  A+ GH  +V +LL   
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757

Query: 325 APILSKTKNGLSPLHMATQGDHLNCVQLL 353
           A     + +G +PL +A +  +++   +L
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  111 bits (277), Expect = 2e-23
 Identities = 73/200 (36%), Positives = 104/200 (52%), Gaps = 10/200 (5%)

Query: 4047 PSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDIRMAIVADHLGLSWT 4106
            P      A D++    PL  +         S    G  S  E+ +++MA++++HLGLSW 
Sbjct: 1365 PCAKGSGAEDRRRTPTPLALRYSIL-----SESTPGSLSGTEQAEMKMAVISEHLGLSWA 1419

Query: 4107 ELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDI 4166
            ELAREL FSV++IN+IRVENPNSL+ QS  LL  WV R+G+NA  + L + L  I+R +I
Sbjct: 1420 ELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEI 1479

Query: 4167 VTLLEGPIFDYGNISGTRSFADEN-NVFHDPVDGWQNETSSGNLESCAQARRVTGGLLDR 4225
            V +LEG      N+   R   D + ++    ++G Q       +       +VT    DR
Sbjct: 1480 VNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGHQR--GQARITHSPTVSQVTERSQDR 1537

Query: 4226 LDDSPDQCRDSITSYLKGEA 4245
            L D       SI SYL+  A
Sbjct: 1538 LQDW--DADGSIVSYLQDAA 1555


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 1743 bits (4514), Expect = 0.0
 Identities = 888/1444 (61%), Positives = 1099/1444 (76%), Gaps = 56/1444 (3%)

Query: 37   KKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR 96
            +++DA  S+LRAAR+G+L+KALD+++NGVDIN CNQNGLN LHLASKEGHV++V ELL +
Sbjct: 8    READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 97   EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156
            E  ++  TKKGNTALHIA+LAGQ EVV+ LV  GANVNAQSQ GFTPLYMAAQENHLEVV
Sbjct: 68   EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 157  KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTK 216
            KFLL+NGA+Q++ATEDGFTPLAVALQQGH+ VV+ L+   TKGKVRLPALHIAAR DDT+
Sbjct: 128  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187

Query: 217  AAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVAS 276
             AA+LLQND N DV SK+GFTPLHIAAHY N+NVA LLLNR A+V+FT +N ITPLH+AS
Sbjct: 188  TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 277  KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS 336
            +RGN  MV+LLLDRGA+I+ KT+D LTPLHC AR+GH ++ E+LLD  API +KTKNGLS
Sbjct: 248  RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 337  PLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK 396
            P+HMA QGDHL+CV+LLLQ++  +DD+T D+LT LHVAAHCGH++VAKVLLDK A PN++
Sbjct: 308  PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367

Query: 397  ALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 456
            ALNGFTPLHIACKKN ++VMELLLK GASI AVTESGLTP+HVA+FMGH+ IV  L+  G
Sbjct: 368  ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 457  ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQ 516
            ASPN +NV+ ET LHMAAR+G  EV +YL+Q+ A+V AKAKDDQTPLH +AR+G  ++V+
Sbjct: 428  ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487

Query: 517  QLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYG 576
             LL+  A+PN ATT+G+TPLH++AREGH +    LL+  AS +  TKKGFTPLHVAAKYG
Sbjct: 488  LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547

Query: 577  KLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLH 636
            K+ VA LLL++ A P+AAGK+GLTPLHVA H++N  +  LLL +G SPH+ A NGYTPLH
Sbjct: 548  KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607

Query: 637  IAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS 696
            IAAK+NQ+++A +LL+YG  ANA + QG+  +HLAAQEGH +MV+LLL + AN NL NKS
Sbjct: 608  IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667

Query: 697  GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKV 756
            GLTPLHL AQE  V VA+VL+  G  VDA T+MGYTPLHV  HYGNIK+V FLLQH A V
Sbjct: 668  GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727

Query: 757  NAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLK 816
            NAKTK GY+PLHQAAQQGHT I+ +LL+N ASPNE++ +G T L IA+RLGYISV D LK
Sbjct: 728  NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787

Query: 817  IVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAM 876
            +VT+ET +   V++KH+M+ PET++E+LD+S+DE             E IS   E  D+ 
Sbjct: 788  VVTDET-SFVLVSDKHRMSFPETVDEILDVSEDE-----------GEELISFKAERRDSR 835

Query: 877  TGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMM 936
              D +K                               L  F       +   +  R    
Sbjct: 836  DVDEEK------------------------------ELLDFVPKLDQVVESPAIPRIPCA 865

Query: 937  IEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGS 996
            + E +V   E+    ++E+D DSL   S A +T DN++ V+SP+H+GFLVSFMVDARGGS
Sbjct: 866  MPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGS 925

Query: 997  MRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQF 1056
            MRGSRH+G+R++IPPR C APTRITCRLVK  KL+ PPP+ E EGLASR++ +GP GAQF
Sbjct: 926  MRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQF 985

Query: 1057 LGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEE 1116
            L PVIVEIPHF S    +REL+VLRSENG  WKEH+       L ++LNGMDEEL S EE
Sbjct: 986  LSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEE 1045

Query: 1117 LGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIR 1176
            L KKR+CRIIT DFP YF ++SR+ Q+ + IGPEGG L S  VPLVQA+FPE A+TKR++
Sbjct: 1046 LEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVK 1105

Query: 1177 VGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKG 1236
            + LQAQPVPDE+V K+LGN+ATFSPIVTVEPRRRKFH+PI + IP+PP   +   +  +G
Sbjct: 1106 LALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEG 1165

Query: 1237 DTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVG 1296
            DTT +LRLLCS+ GGT  AQWEDITGTT L +  +C +FTTNVSARFWL+DC +  E V 
Sbjct: 1166 DTT-SLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVN 1224

Query: 1297 LATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKD 1356
             AT LY+EL  VPYMAKFV+FAKMNDP E  LRC+CMTDDKVDKTLEQ ENF EVARS+D
Sbjct: 1225 FATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRD 1284

Query: 1357 IEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLK 1416
            IEVLEG  ++ +  GNL P+ K  QQ  F+F SF+ENRL   +K+RD+S+EP G LSFL+
Sbjct: 1285 IEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLR 1344

Query: 1417 EPKTTKGLPQTAVCNLNITLPAHKKETESDQDDEIEKTDRRQSFASLALRKRYSYLTE-- 1474
            +    +   Q  +C+LNIT+P   K + ++        DRR++   LAL  RYS L+E  
Sbjct: 1345 KAMKYED-TQHILCHLNITMPPCAKGSGAE--------DRRRTPTPLAL--RYSILSEST 1393

Query: 1475 PGMI 1478
            PG +
Sbjct: 1394 PGSL 1397



 Score =  339 bits (870), Expect = 3e-92
 Identities = 213/618 (34%), Positives = 307/618 (49%), Gaps = 62/618 (10%)

Query: 260 AVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEM 319
           +V F   +  T    A++ GN +     L  G  I+   ++GL  LH  ++ GH ++V  
Sbjct: 4   SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 320 LLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGH 379
           LL +   + + TK G + LH+A        V+ L+ +   V+  +    T L++AA   H
Sbjct: 64  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123

Query: 380 YKVAKVLLDKKANPNAKALNGFTPL-----------------------------HIACKK 410
            +V K LL+  AN N    +GFTPL                             HIA + 
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 411 NRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETAL 470
           +  +   +LL++  +   ++++G TP+H+AA   ++N+   L++ GAS N T   G T L
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 243

Query: 471 HMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATT 530
           H+A+R G   +VR L+  GAQ+E K KD+ TPLH +AR G   I + LL  GA   A T 
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303

Query: 531 SG---------------------------------YTPLHLSAREGHEDVAAFLLDHGAS 557
           +G                                  TPLH++A  GH  VA  LLD GA 
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
            +     GFTPLH+A K   + V  LLL+  AS DA  +SGLTPLHVA+   +  +   L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV 677
           L +GASP+ +     TPLH+AA+    ++A  LL+  A  NA  +     +H AA+ GH 
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483

Query: 678 DMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG 737
           +MV LLL  NAN NL+  +G TPLH+AA+E  V     L+ + A     TK G+TPLHV 
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543

Query: 738 CHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN 797
             YG +++   LL+  A  NA  KNG TPLH A    +  I+ +LL    SP+    NG 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 798 TALGIARRLGYISVVDTL 815
           T L IA +   + V  +L
Sbjct: 604 TPLHIAAKQNQVEVARSL 621



 Score =  211 bits (538), Expect = 1e-53
 Identities = 118/329 (35%), Positives = 181/329 (55%), Gaps = 4/329 (1%)

Query: 29  RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88
           + +++   K  D       AAR GH       ++N  + N+    G   LH+A++EGHVE
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517

Query: 89  VVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA 148
            V  LL++EA+    TKKG T LH+A+  G+  V ++L+   A+ NA  +NG TPL++A 
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577

Query: 149 QENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVR----LP 204
             N+L++VK LL  G S      +G+TPL +A +Q   +V   LL+            + 
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637

Query: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
            LH+AA++   +  ALLL    N ++ +KSG TPLH+ A  G++ VA +L+     VD T
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697

Query: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
            R   TPLHVAS  GN  +VK LL   A ++AKT+ G +PLH  A+ GH  +V +LL   
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757

Query: 325 APILSKTKNGLSPLHMATQGDHLNCVQLL 353
           A     + +G +PL +A +  +++   +L
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  107 bits (268), Expect = 2e-22
 Identities = 59/144 (40%), Positives = 83/144 (57%), Gaps = 5/144 (3%)

Query: 4047 PSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDIRMAIVADHLGLSWT 4106
            P      A D++    PL  +         S    G  S  E+ +++MA++++HLGLSW 
Sbjct: 1365 PCAKGSGAEDRRRTPTPLALRYSIL-----SESTPGSLSGTEQAEMKMAVISEHLGLSWA 1419

Query: 4107 ELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDI 4166
            ELAREL FSV++IN+IRVENPNSL+ QS  LL  WV R+G+NA  + L + L  I+R +I
Sbjct: 1420 ELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEI 1479

Query: 4167 VTLLEGPIFDYGNISGTRSFADEN 4190
            V +LEG      N+   R   D +
Sbjct: 1480 VNMLEGSGRQSRNLKPDRRHTDRD 1503


>gi|32967599 ankyrin 3 isoform 2 [Homo sapiens]
          Length = 1001

 Score = 1197 bits (3096), Expect = 0.0
 Identities = 597/611 (97%), Positives = 599/611 (98%), Gaps = 9/611 (1%)

Query: 871  EGEDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSY 930
            + EDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSY
Sbjct: 5    QSEDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSY 64

Query: 931  ARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMV 990
            ARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMV
Sbjct: 65   ARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMV 124

Query: 991  DARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMG 1050
            DARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMG
Sbjct: 125  DARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMG 184

Query: 1051 PAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEE 1110
            PAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEE
Sbjct: 185  PAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEE 244

Query: 1111 LDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGA 1170
            LDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGA
Sbjct: 245  LDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGA 304

Query: 1171 LTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGV 1230
            LTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGV
Sbjct: 305  LTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGV 364

Query: 1231 SNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQ 1290
            SNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQ
Sbjct: 365  SNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQ 424

Query: 1291 VLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEE 1350
            VLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEE
Sbjct: 425  VLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEE 484

Query: 1351 VARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCG 1410
            VARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCG
Sbjct: 485  VARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCG 544

Query: 1411 RLSFLKEPKTTKGLPQTAVCNLNITLPAHKKETESDQDDEIEKTDRRQSFASLALRKRYS 1470
            RLSFLKEPKTTKGLPQTAVCNLNITLPAHKK         IEKTDRRQSFASLALRKRYS
Sbjct: 545  RLSFLKEPKTTKGLPQTAVCNLNITLPAHKK---------IEKTDRRQSFASLALRKRYS 595

Query: 1471 YLTEPGMIERS 1481
            YLTEPGM  +S
Sbjct: 596  YLTEPGMSPQS 606



 Score =  360 bits (924), Expect = 2e-98
 Identities = 178/178 (100%), Positives = 178/178 (100%)

Query: 4200 WQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITP 4259
            WQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITP
Sbjct: 824  WQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITP 883

Query: 4260 EAKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETK 4319
            EAKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETK
Sbjct: 884  EAKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETK 943

Query: 4320 PCVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS 4377
            PCVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS
Sbjct: 944  PCVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS 1001



 Score =  239 bits (611), Expect = 3e-62
 Identities = 124/148 (83%), Positives = 126/148 (85%), Gaps = 4/148 (2%)

Query: 4057 KKTEAAPLKSKSEKAGSEKRSSRRT----GPQSPCERTDIRMAIVADHLGLSWTELAREL 4112
            KK E    +         KR S  T     PQSPCERTDIRMAIVADHLGLSWTELAREL
Sbjct: 574  KKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPCERTDIRMAIVADHLGLSWTELAREL 633

Query: 4113 NFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEG 4172
            NFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEG
Sbjct: 634  NFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEG 693

Query: 4173 PIFDYGNISGTRSFADENNVFHDPVDGW 4200
            PIFDYGNISGTRSFADENNVFHDPVDG+
Sbjct: 694  PIFDYGNISGTRSFADENNVFHDPVDGY 721


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  328 bits (841), Expect = 7e-89
 Identities = 262/879 (29%), Positives = 384/879 (43%), Gaps = 101/879 (11%)

Query: 18  AEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNA 77
           +EE  +   KH      R K          A +A    +AL  + + V  N+ ++ G  A
Sbjct: 86  SEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNV--NVSDRAGRTA 143

Query: 78  LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
           LH A+  GH E+V  LL R AN++A  KK   A+H A+  G  EVVK+LV++GA V  + 
Sbjct: 144 LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD 203

Query: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE--- 194
           +  +TPL+ AA    + VVK+LLD G   +     G TPL VA   G D VV+ L++   
Sbjct: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263

Query: 195 --NDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVAT 252
             N    K   P    AA         LL+ N  + +++SK G TPLH+ A +G  + + 
Sbjct: 264 IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQ 323

Query: 253 LLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGA-------------------- 292
            ++   A +D   +N  TPLH+A++ G+  ++  L+  GA                    
Sbjct: 324 TIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSG 383

Query: 293 -------------KIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLH 339
                         ID     G T LH  A  G+ + + +LL+  A    K K G SPLH
Sbjct: 384 FSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLH 443

Query: 340 MATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCG-HYKVAKVLLDKKANPNAKAL 398
            A    +  C+  L+     V+D+     T LH AA      K  + LL   ANP  +  
Sbjct: 444 YAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDK 503

Query: 399 NGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG------------LTPIHVAAFMGHV 446
            G+  +H +        ++L+         +  SG            ++P+H+AA+ GH 
Sbjct: 504 QGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHH 563

Query: 447 NIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ--------------- 491
             +  L+      +  N  G T L +AA  G  E V  L+  GA                
Sbjct: 564 QALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHA 623

Query: 492 ----------------------VEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT 529
                                 V+ +  + QTPL +S   G  D V  LL +GA+ +A  
Sbjct: 624 AATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKD 683

Query: 530 TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA 589
             G T LH  A  GHE+    LL HGA   +   +G TP+H++A  G + V   LLQ +A
Sbjct: 684 KWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAA 743

Query: 590 SPDA----AGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMD 645
           S DA    A   G T LH A +  ++    LLL+Q         N ++PLH A   +   
Sbjct: 744 SMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVINDNEG 802

Query: 646 IATTLLE-YGAD-ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHL 703
            A  L++  GA   NA   +G   +H AA   HV+ + LLL  NA VN  + +G TPL +
Sbjct: 803 AAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMM 862

Query: 704 AAQEDRVNVAEVLVNQ-GAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK---VNAK 759
           AA+  + N  E+LV+   A +  Q     T LH+ C  G+      +L+       +NA 
Sbjct: 863 AAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINAT 922

Query: 760 TKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNT 798
                TPLH AA+ G T ++  LL   AS   +  NG T
Sbjct: 923 NAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYT 961



 Score =  318 bits (815), Expect = 7e-86
 Identities = 230/760 (30%), Positives = 375/760 (49%), Gaps = 32/760 (4%)

Query: 85  GHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPL 144
           G  + V  L+ ++ +V+    +  T LH A+  G AE++++L+ +GA VNA+     TPL
Sbjct: 19  GDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPL 78

Query: 145 YMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQ----QGHDQVVSLLLENDTKGK 200
           + A      E V+ LL + A  +   ++  TPL +A      +  + +V LL   +   +
Sbjct: 79  HRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDR 138

Query: 201 VRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAA 260
               ALH AA     +   LLL    N +   K     +H AA+ G+I V  LL++  A 
Sbjct: 139 AGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAE 198

Query: 261 VDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML 320
           V    +   TPLH A+  G  ++VK LLD G  ++     G TPLH    +G + VV  L
Sbjct: 199 VTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNEL 258

Query: 321 LDRAAPILSKTKNGLSPLHMATQGDH-LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGH 379
           +D  A +  K + G +PLH A    H   C++LL+ +   V+  + D  T LH+ A  G 
Sbjct: 259 IDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGR 318

Query: 380 YKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHV 439
           +  ++ ++   A  + +  NG TPLHIA +     ++  L+  GA        G+ P+H+
Sbjct: 319 FSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHL 378

Query: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
           AA  G  +   +L+  G   +T +  G T LH AA  G  E +  L+  GA    K K  
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438

Query: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHE-DVAAFLLDHGASL 558
           ++PLH +A       +  L+  GAS N     G TPLH +A    +     +LL + A+ 
Sbjct: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANP 498

Query: 559 SITTKKGFTPLHVAAKYGK---LEV------ANLLLQKSAS---PDAAGKSGLTPLHVAA 606
            I  K+G+  +H +A YG    L++       ++L++ S +    D+  ++ ++PLH+AA
Sbjct: 499 GIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 558

Query: 607 HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI- 665
           ++ + +   +L+           +G TPL +AA K  ++    L+  G  A+ + +  I 
Sbjct: 559 YHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG--ASILVKDYIL 616

Query: 666 --ASVHLAAQEGHVDMVSLLLG----RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQ 719
               +H AA  GH + + LL+G    +NA V++ + +G TPL L+      +    L+N+
Sbjct: 617 KRTPIHAAATNGHSECLRLLIGNAEPQNA-VDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 675

Query: 720 GAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHII 779
           GA+VDA+ K G T LH G   G+ + V+ LLQH AK   +   G TP+H +A  GH  ++
Sbjct: 676 GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL 735

Query: 780 NVLLQN----NASPNELTVNGNTALGIARRLGYISVVDTL 815
             LLQ+    +A+P     +G TAL  A   G+ + V+ L
Sbjct: 736 GALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775



 Score =  291 bits (746), Expect = 7e-78
 Identities = 245/879 (27%), Positives = 369/879 (41%), Gaps = 122/879 (13%)

Query: 26  RKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEG 85
           +K     +D +K++  +A    AA  G  E     I +G  +N  +   L  LH A    
Sbjct: 30  KKEDVNFQDNEKRTPLHA----AAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASC 85

Query: 86  HVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLY 145
             E V  LL+  A+V+A  K   T LHIA+     +  + LV   +NVN   + G T L+
Sbjct: 86  SEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALH 145

Query: 146 MAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPA 205
            AA   H E+VK LL  GA+ +   +     +  A   GH +VV LL+ +  +       
Sbjct: 146 HAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAE------- 198

Query: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265
                                    + K  +TPLH AA  G I+V   LL+    ++   
Sbjct: 199 ----------------------VTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPN 236

Query: 266 RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQV-VEMLLDRA 324
               TPLHVA   G   +V  L+D GA ++ K   G TPLH  A S H  + +E+L+   
Sbjct: 237 AYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNG 296

Query: 325 APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAK 384
           A +  K+K+G +PLHM       +  Q ++Q    +D    +  T LH+AA  GH  +  
Sbjct: 297 ADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLIN 356

Query: 385 VLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMG 444
            L+   A+   + ++G  PLH+A           LL  G  I    + G T +H AA  G
Sbjct: 357 TLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGG 416

Query: 445 HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLH 504
           ++  ++ L++ GA  N  +  G + LH AA +   + +  LV  GA V    +   TPLH
Sbjct: 417 NLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLH 476

Query: 505 ISARLG-KADIVQQLLQQGASPNAATTSGYTPLHLSAREGH---------EDVAAFLLDH 554
            +A        ++ LL+  A+P      GY  +H SA  GH         E     L++ 
Sbjct: 477 YAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMET 536

Query: 555 GASLSIT---TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQ 611
             +  ++    +   +PLH+AA +G  +   +L+Q     D    SG TPL +AA   + 
Sbjct: 537 SGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHV 596

Query: 612 KVALLLLDQGAS------------PHAAAKNGY-------------------------TP 634
           +   +L++QGAS             HAAA NG+                         TP
Sbjct: 597 ECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTP 656

Query: 635 LHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSN 694
           L ++      D   +LL  GA+ +A  + G  ++H  A  GH + V  LL   A   L +
Sbjct: 657 LMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRD 716

Query: 695 KSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQ----TKMGYTPLHVGCHYGNIKIVNFLL 750
             G TP+HL+A    + V   L+   A +DA        GYT LH  C+ G+   V  LL
Sbjct: 717 SRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL 776

Query: 751 QH----------------------------------SAKVNAKTKNGYTPLHQAAQQGHT 776
           +                                   ++ VNA    G TPLH AA   H 
Sbjct: 777 EQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHV 836

Query: 777 HIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
             + +LL +NA  N +   G T L +A   G  + V+ L
Sbjct: 837 ECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875



 Score =  284 bits (727), Expect = 1e-75
 Identities = 235/768 (30%), Positives = 366/768 (47%), Gaps = 74/768 (9%)

Query: 33  RDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSE 92
           +D+K  +  +A    AA +G +      +  GVD+N  N  G   LH+A   G   VV+E
Sbjct: 202 KDKKSYTPLHA----AASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNE 257

Query: 93  LLQREANVDAATKKGNTALHIASLAGQAEV-VKVLVTNGANVNAQSQNGFTPLYMAAQEN 151
           L+   A V+   +KG T LH A+ +    + +++LV NGA+VN +S++G TPL+M A   
Sbjct: 258 LIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHG 317

Query: 152 HLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN--DT--KGKVRLPALH 207
                + ++ +GA      ++G TPL +A + GH+ +++ L+ +  DT  +G   +  LH
Sbjct: 318 RFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLH 377

Query: 208 IAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN 267
           +AA    +     LL +  + D     G T LH AA  GN+    LLLN  A  +   + 
Sbjct: 378 LAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 437

Query: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHE-QVVEMLLDRAAP 326
             +PLH A+   N   +  L+  GA ++     G TPLH  A S  + + +E LL   A 
Sbjct: 438 GRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDAN 497

Query: 327 ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD--------DVTNDY-----LTALHV 373
              + K G + +H +    H  C+QL+     P+D        D+ +D      ++ LH+
Sbjct: 498 PGIRDKQGYNAVHYSAAYGHRLCLQLIASET-PLDVLMETSGTDMLSDSDNRATISPLHL 556

Query: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
           AA+ GH++  +VL+    + + +  +G TPL +A  K  ++ +++L+  GASI  V +  
Sbjct: 557 AAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI-LVKDYI 615

Query: 434 L--TPIHVAAFMGHVNIVSQLMHHGASPNTTNVR---GETALHMAARSGQAEVVRYLVQD 488
           L  TPIH AA  GH   +  L+ +    N  +++   G+T L ++  +G  + V  L+  
Sbjct: 616 LKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 675

Query: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548
           GA V+AK K  +T LH  A  G  + V  LLQ GA      + G TP+HLSA  GH  V 
Sbjct: 676 GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL 735

Query: 549 AFLLDHGASL----SITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
             LL   AS+    +     G+T LH A   G      LLL++       G +  +PLH 
Sbjct: 736 GALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNA-FSPLHC 794

Query: 605 AAHYDNQKVALLLLDQ-GAS-PHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTR 662
           A   DN+  A +L+D  GAS  +A    G TPLH AA  + ++    LL + A  N+V  
Sbjct: 795 AVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDS 854

Query: 663 QGIA----------------------------------SVHLAAQEGHVDMVSLLLGRNA 688
            G                                    ++HLA  +GH     L+L +  
Sbjct: 855 TGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKIT 914

Query: 689 NVNLSNKSGL---TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTP 733
           + NL N +     TPLH+AA+     V + L+ +GA V A  + GYTP
Sbjct: 915 DRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962



 Score =  268 bits (684), Expect = 1e-70
 Identities = 172/534 (32%), Positives = 264/534 (49%), Gaps = 6/534 (1%)

Query: 263 FTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLD 322
           F    D   L  A   G+ + V+ L+ +   ++ +  +  TPLH  A  G  +++E+L+ 
Sbjct: 3   FLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLIL 62

Query: 323 RAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKV 382
             A + +K    L+PLH A        VQ+LL+H+  V+    ++ T LH+AA     K 
Sbjct: 63  SGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKC 122

Query: 383 AKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAF 442
           A+ L+   +N N     G T LH A      ++++LLL  GA+I A  +     IH AA+
Sbjct: 123 AEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAY 182

Query: 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502
           MGH+ +V  L+ HGA     + +  T LH AA SG   VV+YL+  G  +        TP
Sbjct: 183 MGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP 242

Query: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA-AFLLDHGASLSIT 561
           LH++   G+  +V +L+  GA  N     G+TPLH +A   H  +    L+ +GA +++ 
Sbjct: 243 LHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMK 302

Query: 562 TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621
           +K G TPLH+ A +G+   +  ++Q  A  D   K+G TPLH+AA Y ++ +   L+  G
Sbjct: 303 SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG 362

Query: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVS 681
           A       +G  PLH+AA     D    LL  G D +     G   +H AA  G+++ ++
Sbjct: 363 ADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLN 422

Query: 682 LLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYG 741
           LLL   A+ N  +K G +PLH AA          LV  GA V+   + G TPLH      
Sbjct: 423 LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSD 482

Query: 742 -NIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTV 794
            + K + +LL++ A    + K GY  +H +A  GH     + LQ  AS   L V
Sbjct: 483 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH----RLCLQLIASETPLDV 532



 Score =  158 bits (399), Expect = 1e-37
 Identities = 104/318 (32%), Positives = 157/318 (49%), Gaps = 1/318 (0%)

Query: 499 DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 558
           DQ  L  +   G  D V+ L+ +    N       TPLH +A  G  ++   L+  GA +
Sbjct: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67

Query: 559 SITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618
           +    K  TPLH A      E   +LL+ SA  +A  K+  TPLH+AA     K A  L+
Sbjct: 68  NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127

Query: 619 DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVD 678
              ++ + + + G T LH AA     ++   LL  GA+ NA  ++   ++H AA  GH++
Sbjct: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE 187

Query: 679 MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGC 738
           +V LL+   A V   +K   TPLH AA    ++V + L++ G  ++     G TPLHV C
Sbjct: 188 VVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC 247

Query: 739 HYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI-INVLLQNNASPNELTVNGN 797
           + G   +VN L+   A VN K + G+TPLH AA   H  + + +L+ N A  N  + +G 
Sbjct: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK 307

Query: 798 TALGIARRLGYISVVDTL 815
           T L +    G  S   T+
Sbjct: 308 TPLHMTALHGRFSRSQTI 325



 Score = 43.1 bits (100), Expect = 0.006
 Identities = 26/75 (34%), Positives = 40/75 (53%), Gaps = 3/75 (4%)

Query: 77  ALHLASKEGHVEVVSELLQREAN---VDAATKKGNTALHIASLAGQAEVVKVLVTNGANV 133
           ALHLA  +GH      +L++  +   ++A      T LH+A+  G   VV+ L+  GA+V
Sbjct: 893 ALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV 952

Query: 134 NAQSQNGFTPLYMAA 148
            A  +NG+TP    A
Sbjct: 953 LAVDENGYTPALACA 967


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  324 bits (830), Expect = 1e-87
 Identities = 254/760 (33%), Positives = 360/760 (47%), Gaps = 72/760 (9%)

Query: 78  LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
           LH A+  G  +VV  LLQ  ANV A    G   LH A   G AEVV +L+ +GA+ NA+ 
Sbjct: 62  LHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARD 121

Query: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDT 197
              +TPL+ AA +  ++V   LL +GA  ++   DG T L +A     D     +L  + 
Sbjct: 122 NWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA-----DPSAKAVLTGEY 176

Query: 198 KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257
           K   +   L  A   ++ K  ALL   + N         TPLH+AA Y  + +  LLL  
Sbjct: 177 K---KDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQH 233

Query: 258 AAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317
            A V    + D+ PLH A   G+  + +LL+  GA ++A      TPLH  A     +V 
Sbjct: 234 GADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVC 293

Query: 318 EMLLDRAA-PILSKTKN---------------------GLSPLHMATQGD------HLNC 349
            +LL   A P L    N                     G S L  A + D      HL+ 
Sbjct: 294 SLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSL 353

Query: 350 VQLLLQHNVPVDDVTNDYLTALHVAAHCGHYK---VAKVLLDKKANPNAKALNGFTPLHI 406
             +  +H          + TALH AA   + K   + ++LL K AN N K     TPLH+
Sbjct: 354 EMVNFKH-------PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHV 406

Query: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466
           A +K    V+E+++KH A + A+   G T +H AA+ GH+     L+ +G  PN  +++G
Sbjct: 407 ASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQG 466

Query: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526
            TAL M       E V+ L+Q+G  +     D Q  L  +A+ G  + V++L     S N
Sbjct: 467 FTALQMGN-----ENVQQLLQEGISLGNSEADRQ--LLEAAKAGDVETVKKLCTV-QSVN 518

Query: 527 AATTSGY--TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLL 584
                G   TPLH +A      V  +LL HGA +    K G  PLH A  YG  EVA LL
Sbjct: 519 CRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELL 578

Query: 585 LQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 644
           ++  A  + A     TPLH AA     ++  LLL  GA P    ++G TPL +  K    
Sbjct: 579 VKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDT 637

Query: 645 DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL--TPLH 702
           DI   L            +G A++  AA++G +  V  L   + NVN  +  G   TPLH
Sbjct: 638 DIQDLL------------RGDAALLDAAKKGCLARVKKLSSPD-NVNCRDTQGRHSTPLH 684

Query: 703 LAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKN 762
           LAA  + + VAE L+  GA V+AQ K G  PLH    YG++ +   L++++A VNA  K 
Sbjct: 685 LAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKW 744

Query: 763 GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGI 802
            +TPLH+AAQ+G T +  +LL + A P      G T L +
Sbjct: 745 AFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784



 Score =  251 bits (640), Expect = 1e-65
 Identities = 206/636 (32%), Positives = 303/636 (47%), Gaps = 49/636 (7%)

Query: 46  LRAARAGHLEKALDYIKNGVDINICNQNGLNA--LHLASKEGHVEVVSELLQREANVDAA 103
           L +AR+G+ EK +  +   +++N    +G  +  LHLA+    V++V  LLQ  A+V A 
Sbjct: 182 LESARSGNEEKMMALL-TPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK 240

Query: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163
            K     LH A   G  EV ++LV +GA VNA     FTPL+ AA +N +EV   LL  G
Sbjct: 241 DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300

Query: 164 ASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQ 223
           A  +L      + + +A        +   L  + KG   L A   A      K  +L + 
Sbjct: 301 ADPTLLNCHNKSAIDLA----PTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMV 356

Query: 224 NDNNADVESKSGFTPLHIAA---HYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGN 280
           N  +         T LH AA   +     +  LLL + A ++   +  +TPLHVAS++ +
Sbjct: 357 NFKHPQTHE----TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAH 412

Query: 281 ANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHM 340
            ++V++++   AK++A    G T LH  A  GH Q   +LL         +  G + L M
Sbjct: 413 NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM 472

Query: 341 ATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG 400
             +      VQ LLQ  + + +   D    L  AA  G  +  K L   ++  N + + G
Sbjct: 473 GNEN-----VQQLLQEGISLGNSEAD--RQLLEAAKAGDVETVKKLCTVQS-VNCRDIEG 524

Query: 401 --FTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS 458
              TPLH A   NR+ V+E LL+HGA + A  + GL P+H A   GH  +   L+ HGA 
Sbjct: 525 RQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV 584

Query: 459 PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQL 518
            N  ++   T LH AA  G+ E+ + L+Q GA    K +D  TPL +  + G  DI Q L
Sbjct: 585 VNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDI-QDL 642

Query: 519 LQQGA------------------SP---NAATTSGY--TPLHLSAREGHEDVAAFLLDHG 555
           L+  A                  SP   N   T G   TPLHL+A   + +VA +LL HG
Sbjct: 643 LRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHG 702

Query: 556 ASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVAL 615
           A ++   K G  PLH AA YG ++VA LL++ +A  +A  K   TPLH AA     ++  
Sbjct: 703 ADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCA 762

Query: 616 LLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL 651
           LLL  GA P    + G TPL + +  +   + T  +
Sbjct: 763 LLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAM 798



 Score =  236 bits (601), Expect = 5e-61
 Identities = 182/588 (30%), Positives = 270/588 (45%), Gaps = 55/588 (9%)

Query: 264 TARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDR 323
           TA    TPLH A+  G  ++V+ LL  GA + A+   GL PLH     GH +VV +LL  
Sbjct: 54  TAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRH 113

Query: 324 AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVA------AHC 377
            A   ++     +PLH A     ++   +LLQH         D  TAL +A         
Sbjct: 114 GADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLT 173

Query: 378 GHYKVAKVLLDKKA-------------NPNAKALNG--FTPLHIACKKNRIKVMELLLKH 422
           G YK  ++L   ++             N N  A +G   TPLH+A   NR+K+++LLL+H
Sbjct: 174 GEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQH 233

Query: 423 GASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVV 482
           GA + A  +  L P+H A   GH  +   L+ HGA  N  ++   T LH AA   + EV 
Sbjct: 234 GADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVC 293

Query: 483 RYLVQDGAQ-----VEAKAKDDQTPL-HISARLGKADIVQQLLQQGASPNAATTSGY--- 533
             L+  GA         K+  D  P   +  RL        LLQ     +      +   
Sbjct: 294 SLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSL 353

Query: 534 ------------TPLHLSAREGH---EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKL 578
                       T LH +A   +   + +   LL  GA+++  TK+  TPLHVA++    
Sbjct: 354 EMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHN 413

Query: 579 EVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638
           +V  ++++  A  +A    G T LH AA+  + +   LLL  G  P+  +  G+T L + 
Sbjct: 414 DVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG 473

Query: 639 AKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL 698
            +  Q      LL+ G        +    +  AA+ G V+ V  L    + VN  +  G 
Sbjct: 474 NENVQQ-----LLQEGISLG--NSEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGR 525

Query: 699 --TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKV 756
             TPLH AA  +RV+V E L+  GA V A+ K G  PLH  C YG+ ++   L++H A V
Sbjct: 526 QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVV 585

Query: 757 NAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIAR 804
           N      +TPLH+AA +G   I  +LLQ+ A P +   +GNT L + +
Sbjct: 586 NVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVK 633



 Score =  234 bits (598), Expect = 1e-60
 Identities = 210/696 (30%), Positives = 292/696 (41%), Gaps = 93/696 (13%)

Query: 196 DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLL 255
           DT G+   P LH AA          LLQN  N       G  PLH A  +G+  V  LLL
Sbjct: 53  DTAGRKSTP-LHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLL 111

Query: 256 NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG------- 308
              A  +     + TPLH A+ +G  ++  +LL  GA+   +  DG T L          
Sbjct: 112 RHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAV 171

Query: 309 -------------ARSGHEQVVEMLLDRAAPILSKTKNGLS-PLHMATQGDHLNCVQLLL 354
                        ARSG+E+ +  LL         +    S PLH+A   + +  VQLLL
Sbjct: 172 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLL 231

Query: 355 QHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIK 414
           QH   V       L  LH A   GHY+V ++L+   A  NA  L  FTPLH A  KNR++
Sbjct: 232 QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVE 291

Query: 415 VMELLLKHGASIQAVTESGLTPIHVAA-----------FMGHVNI-------VSQLMHHG 456
           V  LLL +GA    +     + I +A            F GH  +       V+++  H 
Sbjct: 292 VCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKH- 350

Query: 457 ASPNTTNVRG----ETALHMAARSG---QAEVVRYLVQDGAQVEAKAKDDQTPLHISARL 509
            S    N +     ETALH AA S    + ++   L++ GA +  K K+  TPLH+++  
Sbjct: 351 LSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEK 410

Query: 510 GKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPL 569
              D+V+ +++  A  NA    G T LH +A  GH      LL +G   +I + +GFT L
Sbjct: 411 AHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTAL 470

Query: 570 HV--------------------------AAKYGKLEVANLL--LQKSASPDAAGKSGLTP 601
            +                          AAK G +E    L  +Q     D  G+   TP
Sbjct: 471 QMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQS-TP 529

Query: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
           LH AA Y+   V   LL  GA  HA  K G  PLH A      ++A  L+++GA  N   
Sbjct: 530 LHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVAD 589

Query: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721
                 +H AA +G  ++  LLL   A+    N+ G TPL L    D  ++ ++L    A
Sbjct: 590 LWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGD-TDIQDLLRGDAA 648

Query: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGY--TPLHQAAQQGHTHII 779
            +DA  K        GC    +K     L     VN +   G   TPLH AA   +  + 
Sbjct: 649 LLDAAKK--------GC-LARVK----KLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVA 695

Query: 780 NVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
             LLQ+ A  N     G   L  A   G++ V   L
Sbjct: 696 EYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALL 731



 Score =  169 bits (429), Expect = 4e-41
 Identities = 135/496 (27%), Positives = 220/496 (44%), Gaps = 52/496 (10%)

Query: 407 ACKKNRI-KVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVR 465
           AC+   + +V  L+     + +       TP+H AA  G  ++V  L+ +GA+    +  
Sbjct: 31  ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90

Query: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 525
           G   LH A   G AEVV  L++ GA   A+   + TPLH +A  GK D+   LLQ GA P
Sbjct: 91  GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150

Query: 526 NAATTSGYTPLHL--------------------SAREGHED-VAAFLLDHGASLSITTKK 564
               T G T L L                    SAR G+E+ + A L     +   +  +
Sbjct: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210

Query: 565 GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624
             TPLH+AA Y ++++  LLLQ  A   A  K  L PLH A  Y + +V  LL+  GA  
Sbjct: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACV 270

Query: 625 HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 684
           +A     +TPLH AA KN++++ + LL YGAD   +     +++ LA      + ++   
Sbjct: 271 NAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEF 330

Query: 685 GRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGC---HYG 741
             ++ +  + ++ +T +      + VN      ++            T LH      +  
Sbjct: 331 KGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHE------------TALHCAAASPYPK 378

Query: 742 NIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALG 801
             +I   LL+  A +N KTK   TPLH A+++ H  ++ V++++ A  N L   G T+L 
Sbjct: 379 RKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSL- 437

Query: 802 IARRLGYISVVDTLKIVTEE-------TMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKA 854
              R  Y   + T +++          ++   T  +    NV + + E + + + E    
Sbjct: 438 --HRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSE---- 491

Query: 855 NAPEMLSDGEYISDVE 870
            A   L +     DVE
Sbjct: 492 -ADRQLLEAAKAGDVE 506


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  310 bits (795), Expect = 2e-83
 Identities = 250/792 (31%), Positives = 362/792 (45%), Gaps = 55/792 (6%)

Query: 39  SDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNA--LHLASKEGHVEVVSELLQR 96
           S A    L A R G + +    + +  ++N  +  G  +  LH A+  G  +VV  LLQ 
Sbjct: 180 SGALRELLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQM 238

Query: 97  EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156
            ANV A    G   LH A   G AEVV +L+  GA+ NA+    +TPL+ AA +  ++V 
Sbjct: 239 GANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVC 298

Query: 157 KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTK 216
             LL +GA  ++   DG + L +A     D     +L  + K    L A   A   ++ K
Sbjct: 299 IVLLQHGADPNIRNTDGKSALDLA-----DPSAKAVLTGEYKKDELLEA---ARSGNEEK 350

Query: 217 AAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVAS 276
             ALL   + N         TPLH+AA Y  + +  LLL   A V    +  + PLH A 
Sbjct: 351 LMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNAC 410

Query: 277 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS 336
             G+  + +LLL  GA ++A      TPLH  A     +V  +LL   A       +G S
Sbjct: 411 SYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKS 470

Query: 337 PLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK 396
            + MA   +        L+  +  +   +  L A   A      K   + +     P + 
Sbjct: 471 AVDMAPTPE--------LRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSH 522

Query: 397 ALNGFTPLHIACKK---NRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM 453
                T LH A       R +V ELLL+ GA++    +  +TP+HVAA   H +++  L 
Sbjct: 523 E----TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLH 578

Query: 454 HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD 513
            HGA  N  +  G+TALH AA +G  +  R L+  G+     +    T    +A++G  +
Sbjct: 579 KHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGN-E 633

Query: 514 IVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA 573
            VQQ+L + ++P   +   Y  L  S     E V         +      +  TPLH AA
Sbjct: 634 AVQQILSE-STPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAA 692

Query: 574 KYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYT 633
            Y ++ V   LL   A   A  K GL PLH A  Y + +VA LL+  GAS + A    +T
Sbjct: 693 GYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFT 752

Query: 634 PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA----- 688
           PLH AA K + +I   LL++GAD     R G   + L  +EG  D+  LL G  A     
Sbjct: 753 PLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLRGDAALLDAA 811

Query: 689 ---------------NVNLSNKSGL--TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY 731
                          N+N  +  G   TPLHLAA  + + VAE L+  GA V+AQ K G 
Sbjct: 812 KKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGL 871

Query: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791
            PLH    YG++ I   L++++  VNA  K  +TPLH+AAQ+G T +  +LL + A P  
Sbjct: 872 IPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTM 931

Query: 792 LTVNGNTALGIA 803
               G T L +A
Sbjct: 932 KNQEGQTPLDLA 943



 Score =  248 bits (632), Expect = 1e-64
 Identities = 203/658 (30%), Positives = 294/658 (44%), Gaps = 69/658 (10%)

Query: 46  LRAARAGHLEKALDYIKNGVDINICNQNGLNA--LHLASKEGHVEVVSELLQREANVDAA 103
           L AAR+G+ EK +  +   +++N    +G  +  LHLA+    V +V  LLQ  A+V A 
Sbjct: 340 LEAARSGNEEKLMALL-TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK 398

Query: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163
            K G   LH A   G  EV ++L+ +GA VNA     FTPL+ AA +N +EV   LL +G
Sbjct: 399 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 458

Query: 164 ASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQ 223
           A  +L    G +    A+       +   L  + KG   L A   A      K  AL + 
Sbjct: 459 ADPTLVNCHGKS----AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEII 514

Query: 224 NDNNADVESKSGFTPLHIAA---HYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGN 280
           N      + +S  T LH A    H     V  LLL + A V+   ++ +TPLHVA++R +
Sbjct: 515 NFK----QPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAH 570

Query: 281 ANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHM 340
            +++++L   GAK++A    G T LH  A +GH Q   +LL   +     +  G +   M
Sbjct: 571 NDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQM 630

Query: 341 ATQ---------------------------GDHLNCVQLLLQHNVPVDDVTNDYLTALHV 373
             +                           GD     QL    NV   D+   + T LH 
Sbjct: 631 GNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHF 690

Query: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
           AA      V + LL   A+ +AK   G  PLH AC     +V ELL++HGAS+       
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750

Query: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE 493
            TP+H AA  G   I   L+ HGA P   N  G T L +  + G  ++   L  D A ++
Sbjct: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLRGDAALLD 809

Query: 494 AKAKD----------------------DQTPLHISARLGKADIVQQLLQQGASPNAATTS 531
           A  K                       + TPLH++A     ++ + LL+ GA  NA    
Sbjct: 810 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869

Query: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591
           G  PLH +A  GH D+AA L+ +   ++ T K  FTPLH AA+ G+ ++  LLL   A P
Sbjct: 870 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 929

Query: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATT 649
               + G TPL +A   D   +  LL+D  A P  A    + P       + +  A+T
Sbjct: 930 TMKNQEGQTPLDLATADD---IRALLID--AMPPEALPTCFKPQATVVSASLISPAST 982



 Score =  223 bits (569), Expect = 2e-57
 Identities = 202/684 (29%), Positives = 292/684 (42%), Gaps = 84/684 (12%)

Query: 275 ASKRGNANMVKLLLDRGAKIDAKTRDGL--TPLHCGARSGHEQVVEMLLDRAAPILSKTK 332
           A + G+ + VK L+D  A ++AK   G   +PLH  A  G + VVE LL   A + ++  
Sbjct: 189 ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 247

Query: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
            GL PLH A    H   V LLL      +   N   T LH AA  G   V  VLL   A+
Sbjct: 248 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAD 307

Query: 393 PNAKALNGFTPLHIA-----------CKKNRI----------KVMELLLKHGASIQAVTE 431
           PN +  +G + L +A            KK+ +          K+M LL     +  A   
Sbjct: 308 PNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDG 367

Query: 432 SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ 491
              TP+H+AA    V IV  L+ HGA  +  +  G   LH A   G  EV   L++ GA 
Sbjct: 368 RKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC 427

Query: 492 VEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPL------HLSAREGHE 545
           V A      TPLH +A   + ++   LL  GA P      G + +       L  R  +E
Sbjct: 428 VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYE 487

Query: 546 DVAAFLLDHGASLSITTKKGF---------------TPLH--VAAKYGKL-EVANLLLQK 587
                LL       +   K                 T LH  VA+ + K  +V  LLL+K
Sbjct: 488 FKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRK 547

Query: 588 SASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIA 647
            A+ +   K  +TPLHVAA   +  V  +L   GA  +A    G T LH AA    +   
Sbjct: 548 GANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTC 607

Query: 648 TTLLEYGADANAVTRQGIASVHL--------------------------AAQEGHVDMVS 681
             LL YG+D + ++ QG  +  +                          A++ G ++ V 
Sbjct: 608 RLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVK 667

Query: 682 LLLGRNANVNLSNKSGL--TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCH 739
            L   + NVN  +  G   TPLH AA  +RV+V E L++ GA V A+ K G  PLH  C 
Sbjct: 668 QLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACS 726

Query: 740 YGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTA 799
           YG+ ++   L++H A VN      +TPLH+AA +G   I  +LL++ A P +   +GNT 
Sbjct: 727 YGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTP 786

Query: 800 LGIARRLGYISVVDTLK--IVTEETMTTTTVTEKHKMNVPETMN--EVLDMSDDEVRKAN 855
           L + +  G   + D L+      +      +    K+  PE +N  +    +   +  A 
Sbjct: 787 LDLVKE-GDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAA 845

Query: 856 APEMLSDGEYISDVEEGEDAMTGD 879
               L   EY+  +E G D    D
Sbjct: 846 GYNNLEVAEYL--LEHGADVNAQD 867



 Score =  121 bits (304), Expect = 1e-26
 Identities = 112/412 (27%), Positives = 170/412 (41%), Gaps = 67/412 (16%)

Query: 29  RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88
           RK +   +K  D       AA   H +      K+G  +N  +  G  ALH A+  GH++
Sbjct: 546 RKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQ 605

Query: 89  VVSELLQREANVDAATKKGNTALHI--------------------------ASLAGQAEV 122
               LL   ++    + +G TA  +                          AS AG  E 
Sbjct: 606 TCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLET 665

Query: 123 VKVLVTNGANVNAQSQNG--FTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180
           VK L ++  NVN +   G   TPL+ AA  N + VV++LL +GA      + G  PL  A
Sbjct: 666 VKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNA 724

Query: 181 LQQGHDQVVSLLLENDTKGKV----RLPALHIAARKDDTKAAALLLQNDNNADVESKSGF 236
              GH +V  LL+ +     V    +   LH AA K   +   LLL++  +   +++ G 
Sbjct: 725 CSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGN 784

Query: 237 TPLHIAAHYGNINVATLLLNRAAAVDF----------------------TARNDITPLHV 274
           TPL +    G+ ++  LL   AA +D                       T   + TPLH+
Sbjct: 785 TPLDLVKE-GDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHL 843

Query: 275 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 334
           A+   N  + + LL+ GA ++A+ + GL PLH  A  GH  +  +L+     + +  K  
Sbjct: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWA 903

Query: 335 LSPLHMATQGDHLNCVQLLLQH-----------NVPVDDVTNDYLTALHVAA 375
            +PLH A Q        LLL H             P+D  T D + AL + A
Sbjct: 904 FTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDA 955


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score =  303 bits (775), Expect = 3e-81
 Identities = 259/844 (30%), Positives = 397/844 (47%), Gaps = 47/844 (5%)

Query: 46   LRAARAGHLEKALDYIKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAAT 104
            + A  AGH+E A   ++NG  IN   N+   +AL LA  +GH+E+V  LL+  A+ +  T
Sbjct: 372  MEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKT 431

Query: 105  KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
             + +TAL  A + G  EV ++L+ +GA VN  + +  +PL +AA   H+E+   L++ GA
Sbjct: 432  DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491

Query: 165  SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN 224
            S     ++G+TPL  A ++GH+++V+LLL             +I A+ ++T+  AL L  
Sbjct: 492  SLEEVNDEGYTPLMEAAREGHEEMVALLLGQ---------GANINAQTEETQETALTLAC 542

Query: 225  DNN----ADVESKSG-------FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLH 273
                   AD   K+G        TPL  AA  G++ +   LL   A V  T     T L 
Sbjct: 543  CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602

Query: 274  VASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT-K 332
             A + G+ ++  +LL  GA ++ ++  G TPL   AR+GH   V+ L+ + A +   T  
Sbjct: 603  YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662

Query: 333  NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
            N  + L +A  G HL  V+LLL H         D  T L  AA  GH  V   LLD   N
Sbjct: 663  NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722

Query: 393  ----PNAKALNGFTPLHIACKKNRIKVMELLL---KHGASIQAVTESGLTPIHVAAFMGH 445
                P         P H   +  R+ V  L +              +   PI   A  G 
Sbjct: 723  LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGR 782

Query: 446  VNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHI 505
             + +S    H  + + +  +  T   + + S    +   +  D AQ E+   +  T L +
Sbjct: 783  ASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDID-AQTES---NHDTALTL 838

Query: 506  SARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKK- 564
            +   G  ++VQ LL++GAS       G+TPL L+A  GH  V   LLD+GA +   +++ 
Sbjct: 839  ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 898

Query: 565  GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGA-- 622
              TPL +A   G+ EV  LLL + A+ +    S  TPL +AA      +  +LL+ GA  
Sbjct: 899  KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 958

Query: 623  SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA-VTRQGIASVHLAAQEGHVDMVS 681
            +    +K G +PL +AA          LL+ G+D NA +      ++ LA  +G  ++VS
Sbjct: 959  NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS 1018

Query: 682  LLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQ--TKMGYTPLHVGCH 739
            LLL R ANV    K+GLTPL  AA      V  VL+++GA V+A        T L +   
Sbjct: 1019 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1078

Query: 740  YGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTA 799
             G+ K    L+   A ++ + K G TPL  AA  GH  ++ +L+Q  A  +       T 
Sbjct: 1079 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP 1138

Query: 800  LGIARRLGYISVVDTL-KIVTE-----ETMT-TTTVTEKHKMNVPE-TMNEVLDMSDDEV 851
            L  A R G++ VV  L K V +     E M    T+T+K  +      M  ++   D + 
Sbjct: 1139 LMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQA 1198

Query: 852  RKAN 855
             +AN
Sbjct: 1199 AEAN 1202



 Score =  276 bits (706), Expect = 3e-73
 Identities = 248/829 (29%), Positives = 373/829 (44%), Gaps = 100/829 (12%)

Query: 72   QNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAE---------- 121
            Q+   +L  A  EG V  V +LL    +V+  T++G + L +A  AG  E          
Sbjct: 232  QSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 291

Query: 122  ------------------------VVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVK 157
                                    +VK+L+ + A+VNAQS  G T L  A    +++VVK
Sbjct: 292  NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVK 351

Query: 158  FLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDT-----KGKVRLPALHIAARK 212
             LL++GAS     E+G TPL  A   GH +V  LLLEN         + +  AL +A  K
Sbjct: 352  VLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYK 411

Query: 213  DDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPL 272
               +    LL+   + + ++    T L  A   G++ VA LLL+  A V+  A +  +PL
Sbjct: 412  GHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 471

Query: 273  HVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTK 332
             +A+  G+  +  LL++RGA ++    +G TPL   AR GHE++V +LL + A I ++T+
Sbjct: 472  TLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTE 531

Query: 333  NGL-SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
                + L +A  G  L     L++      D+     T L  AA  GH ++ K LL   A
Sbjct: 532  ETQETALTLACCGGFLEVADFLIKAGA---DIELGCSTPLMEAAQEGHLELVKYLLAAGA 588

Query: 392  NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQ 451
            N +A    G T L  AC+     V ++LL+ GA ++  +E G TP+  AA  GHV  V  
Sbjct: 589  NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648

Query: 452  LMHHGASPNTTNVRGE-TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG 510
            L+  GA+ N T    + T L +A   G   VV  L+  GA    + KD  T L  +A+ G
Sbjct: 649  LISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 708

Query: 511  KADIVQQLL-----------------------------------------QQGASP--NA 527
               +V  LL                                         Q+   P  N 
Sbjct: 709  HTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANV 768

Query: 528  ATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587
            ATT    P+   A  G     +    H  + SI+  +  TP  + +       A L +  
Sbjct: 769  ATT---LPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIIS-----PSAMLPIYP 820

Query: 588  SASPDAAGKSGL-TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDI 646
            +   DA  +S   T L +A    ++++   LL++GAS     K G+TPL +AA    + +
Sbjct: 821  AIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 880

Query: 647  ATTLLEYGADANAVT-RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAA 705
               LL+ GAD  A + R     + LA   G  ++V LLL R AN    N S  TPL LAA
Sbjct: 881  VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 940

Query: 706  QEDRVNVAEVLVNQGAHVDAQT--KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTK-N 762
                VN+ ++L+N GA ++++T  K+G +PL +    G+   V  LL   + +NA+ + N
Sbjct: 941  SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETN 1000

Query: 763  GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISV 811
              T L  A  QG T ++++LL   A+       G T L  A   GY  V
Sbjct: 1001 RNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1049



 Score = 76.3 bits (186), Expect = 6e-13
 Identities = 52/146 (35%), Positives = 74/146 (50%), Gaps = 1/146 (0%)

Query: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHV-DAQTKM 729
           A  EG V+ V  LL    +VN   + G + L LA       +A+VL+   A+V D   K 
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300

Query: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP 789
             TPL    + G++KIV  LL H A VNA++  G T L  A   G+  ++ VLL++ AS 
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360

Query: 790 NELTVNGNTALGIARRLGYISVVDTL 815
            +   NG+T L  A   G++ V   L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLL 386



 Score = 40.8 bits (94), Expect = 0.030
 Identities = 110/508 (21%), Positives = 193/508 (37%), Gaps = 76/508 (14%)

Query: 1468 RYSYLTEPGMIERSTGATRSLPTTYSYKPFFSTRPYQSWTTAP----------ITVPGPA 1517
            R+S     G    S G+  S PTT +     ST P  S   +P          +TV   +
Sbjct: 1697 RHSNQNSSGSQVNSAGSLTSSPTTTTSSSA-STVPGTSTNGSPSSPSVRRQLFVTVVKTS 1755

Query: 1518 KSGFTSLSSSSSNT-----------PSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISD 1566
             +  T++++++SN            P+A     + S S+PSP     G S  S +   S 
Sbjct: 1756 NATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSA 1815

Query: 1567 VASPIRSFRTM---SSPIKTVVSQSPYNIQVSSGTLA------RAPAVTEATPLKGLASN 1617
              + + S       S P+    +  P N   SSG+ +      + P      P   L  +
Sbjct: 1816 SPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQS 1875

Query: 1618 ST-----------FSSRTSPVTTAGSLLERSSITMTPPASPKSNINMYSSSLPFKSIITS 1666
                          ++ ++PV    +      +  TP   P+    M + ++      T+
Sbjct: 1876 QVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTT 1935

Query: 1667 AAPLISSPLKSVVSPVKSAVDVISSAKITMASSLSSPVKQMPGHAEVALVNGSISPLKYP 1726
            A      P K+  S   S+V V+S   I    S+ S V+     +  +    S+ P   P
Sbjct: 1936 A------PHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSACQNSVHPANKP 1989

Query: 1727 ----SSSTLINGCKATATLQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFS-PL-RS 1780
                 S+ L  G  +T       S+      SVVS+ +     +   ++ +P S PL +S
Sbjct: 1990 IAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQS 2049

Query: 1781 YVSAAPSAFQSLRTPSAS-ALYTSLGSSISATTSSVT------SSIITVPVYSVVNVLPE 1833
              S AP     L+ P+ S +   ++ S   + T S T      S+I    +Y      P 
Sbjct: 2050 DTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYG-----PG 2104

Query: 1834 PALKKLPDSNSFTK---SAAALLSPIKTLTTETHPQPHFSRTSSPVKSSLFLAPSALKLS 1890
              L   P + +F +   S  +LL+P  + + ++  Q   S   +P       APS++ L 
Sbjct: 2105 APLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSP-----APSSVPLG 2159

Query: 1891 T--PSSLSSSQEILKDVAEMKEDLMRMT 1916
            +  PS++S  +++   +   +   +R T
Sbjct: 2160 SEKPSNVSQDRKVPVPIGTERSARIRQT 2187



 Score = 36.2 bits (82), Expect = 0.74
 Identities = 49/229 (21%), Positives = 75/229 (32%), Gaps = 36/229 (15%)

Query: 3866 PIKAT-SPKDTFPPNHMS-NTKASKMKQVSQSEKTKALTTSSCVDVKSRIPVKNTHRDNI 3923
            P +AT SPK    P H + N+  S++        +   TTSS     S +P         
Sbjct: 1683 PARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSA---STVP--------- 1730

Query: 3924 IAVRKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVTTTTTTATTTTTTTTTTTTSCTVK 3983
                    T   G P     +          R   VT   T+  TTTT TTT + + T  
Sbjct: 1731 -------GTSTNGSPSSPSVR----------RQLFVTVVKTSNATTTTVTTTASNNNTAP 1773

Query: 3984 VRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSLSETSR 4043
               +      K         S         +S       S L     S ++  S SE   
Sbjct: 1774 TNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSR-----NSPLDCGSASPNKVASSSEQEA 1828

Query: 4044 GGQPSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDI 4092
            G  P V T + R   + ++   S +     +   S    P+ P +++ +
Sbjct: 1829 GSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQV 1877



 Score = 33.1 bits (74), Expect = 6.2
 Identities = 19/61 (31%), Positives = 31/61 (50%), Gaps = 2/61 (3%)

Query: 35   RKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELL 94
            R KK   N     AA  GHL+     ++ G D++  +   +  L  A ++GHV+VV  L+
Sbjct: 1098 RNKKG--NTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155

Query: 95   Q 95
            +
Sbjct: 1156 K 1156



 Score = 33.1 bits (74), Expect = 6.2
 Identities = 85/416 (20%), Positives = 149/416 (35%), Gaps = 53/416 (12%)

Query: 1519 SGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSSVK-------SISDVASPI 1571
            SG  S+  S + +   S   S  + S PSP+ S  G  T +S K          +V    
Sbjct: 1417 SGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRS 1476

Query: 1572 RSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAVTEATPLKGLASNSTFSSRTSPVTTAG 1631
            +     S+ I  V+ +   NI           A  +    K    +   + R    +T  
Sbjct: 1477 KKVSVPSTVISRVIGRGGCNINAIREFTG---AHIDIDKQKDKTGDRIITIRGGTESTRQ 1533

Query: 1632 SLLERSSITMTPPAS-----PKSNINMYSSSLPFKSIITSAAPLISSPLKSVVSPVKSAV 1686
            +    +++   P        PK+ +   S++    S I S+AP  ++   S++    + V
Sbjct: 1534 ATQLINALIKDPDKEIDELIPKNRLKSSSAN----SKIGSSAPTTTAANTSLMGIKMTTV 1589

Query: 1687 DVISSAKITMA------------SSLSSPVKQMPGHAEVALVNGSISPLKYPSSSTLING 1734
             + S+++   A             ++ +PV  +     V+L      PL YP      + 
Sbjct: 1590 ALSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPVSL------PLAYPPPQ-FAHA 1642

Query: 1735 CKATATLQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFSPLRSYVSAAPSAF-QSLR 1793
              A  T Q+          +         +  +      P SP R+  S  P    +   
Sbjct: 1643 LLAAQTFQQ--IRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSN 1700

Query: 1794 TPSASALYTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPALKK------LPDSNSFTK 1847
              S+ +   S GS  S+ T++ +SS  TVP  S       P++++      +  SN+ T 
Sbjct: 1701 QNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTT 1760

Query: 1848 SAAALLSPIKTL-TTETHPQP----HFSRTSSPVKSSLFLAPSALKLSTPSSLSSS 1898
            +     S   T  T  T+P P    H+   SSP   S    P  +  ++P    S+
Sbjct: 1761 TVTTTASNNNTAPTNATYPMPTAKEHYP-VSSPSSPSPPAQPGGVSRNSPLDCGSA 1815


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  301 bits (770), Expect = 1e-80
 Identities = 253/883 (28%), Positives = 378/883 (42%), Gaps = 117/883 (13%)

Query: 66  DINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKV 125
           D+N  +      LH+A+  G  E++  L+   A V+A      T LH A  +   E V+V
Sbjct: 8   DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67

Query: 126 LVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGH 185
           L+ + A+VNA+ +N  TPL++AA    ++  + ++   +S +++   G T L  A   GH
Sbjct: 68  LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127

Query: 186 DQVVSLLLENDTK----GKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHI 241
            ++V+LLL          K    ALH AA        ALL+ +      + K G+TPLH 
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHA 187

Query: 242 AAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDG 301
           AA  G INV   LLN    +D       T LH+A   G   +V  L+D GA ++    +G
Sbjct: 188 AASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNG 247

Query: 302 LTPLHCGARSGHEQV-VEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPV 360
            TPLH  A S H  + +E+L++  A +  ++K+G SPLHM          Q L+Q+   +
Sbjct: 248 FTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEI 307

Query: 361 DDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIA--------CKK-- 410
           D V  D  T LHVAA  GH  +   L    A+     ++   PLH+A        C+K  
Sbjct: 308 DCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLL 367

Query: 411 -----------------------NRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 447
                                    ++ ++LL   GA      + G TP+H AA   H +
Sbjct: 368 SSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFH 427

Query: 448 IVSQLMHHGASPNTTNVRGETALHMAARS---------GQAE------------------ 480
            +  L+  GA+ N T+  G TALH AA S         G A                   
Sbjct: 428 CIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEAT 487

Query: 481 -VVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYT--PLH 537
             + +L+Q+ A    + K+    +H +A  G    ++ LL++  S    + SG T  PLH
Sbjct: 488 LCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLH 547

Query: 538 LSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS---PDAA 594
           L+A  GH      LL     L I  +KG T L +AA  G  E    L+   AS    D  
Sbjct: 548 LAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNV 607

Query: 595 GKSGLTPLHVAAHYDNQKVALLLLDQGASPHAA---AKNGYTPLHIAAKKNQMDIATTLL 651
            K   TPLH +    +     LLL+   +P A       G TPL +A     +D  + LL
Sbjct: 608 TKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665

Query: 652 EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVN 711
           E  A+ + V   G  ++H     GH + V +LL +  ++   +  G TPLH AA      
Sbjct: 666 EKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHAT 725

Query: 712 -VAEVLVNQGAHVDA--QTKMGYTPLHVGCHYGNIKIVNFLLQH---------------- 752
            ++E+L    +  D   +   GYTPLH  C+ GN   +  LL+                 
Sbjct: 726 WLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHC 785

Query: 753 ------------------SAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTV 794
                             S+ V+ +   G TPL  AA   H   + +LL+++A  N +  
Sbjct: 786 AIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDN 845

Query: 795 NGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVP 837
           +G TAL +A   G    VD   I+        TV +K  +N P
Sbjct: 846 SGKTALMMAAENGQAGAVD---ILVNSAQADLTVKDK-DLNTP 884



 Score =  300 bits (767), Expect = 3e-80
 Identities = 229/776 (29%), Positives = 356/776 (45%), Gaps = 52/776 (6%)

Query: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
           AA  GHL+     I +G ++   ++ G   LH A+  G + VV  LL     +D     G
Sbjct: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214

Query: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEV-VKFLLDNGASQ 166
           NTALHIA   GQ  VV  L+  GANVN  + NGFTPL+ AA   H  + ++ L++NGA  
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274

Query: 167 SLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDN 226
           ++ ++DG +PL                         + A+H    +  T     L+QN  
Sbjct: 275 NIQSKDGKSPL------------------------HMTAVHGRFTRSQT-----LIQNGG 305

Query: 227 NADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKL 286
             D   K G TPLH+AA YG+  +   L    A       + + PLH+A+   +++  + 
Sbjct: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365

Query: 287 LLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDH 346
           LL  G +ID   + G T LH  A  G+ + +++L    A    K K G +PLH A    H
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425

Query: 347 LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI 406
            +C++ L+     V++  +   TALH AA     +   +L    A+ N++ L     L  
Sbjct: 426 FHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTIL--GNAHDNSEELERARELK- 482

Query: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466
             +K     +E LL++ A+     + G   IH AA  GH   +  L+    S    +  G
Sbjct: 483 --EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540

Query: 467 ET--ALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGAS 524
            T   LH+AA +G  + +  L+Q    ++ + +  +T L ++A  G  + V+ L+  GAS
Sbjct: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600

Query: 525 PNAA-TTSGYTPLHLSAREGHEDVAAFLL---DHGASLSITTKKGFTPLHVAAKYGKLEV 580
                  +  TPLH S   GH      LL   D+  ++ +   KG TPL +A  YG ++ 
Sbjct: 601 IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDA 660

Query: 581 ANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAK 640
            +LLL+K A+ D     G T LH      +++   +LL+Q  S       G TPLH AA 
Sbjct: 661 VSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAA 720

Query: 641 KNQMDIATTLLEYG---ADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697
           +      + LL+      D      QG   +H A   G+ + + +LL +         + 
Sbjct: 721 RGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-NP 779

Query: 698 LTPLHLAAQEDRVNVAEVLVN--QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK 755
            TPLH A   D  N A +L+     + V  +   G TPL       +++ +  LL+HSA 
Sbjct: 780 FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAP 839

Query: 756 VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNG---NTALGIARRLGY 808
           VNA   +G T L  AA+ G    +++L+  N++  +LTV     NT L +A   G+
Sbjct: 840 VNAVDNSGKTALMMAAENGQAGAVDILV--NSAQADLTVKDKDLNTPLHLACSKGH 893



 Score =  299 bits (766), Expect = 4e-80
 Identities = 220/746 (29%), Positives = 341/746 (45%), Gaps = 43/746 (5%)

Query: 93  LLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENH 152
           L+ +  +V+    +  T LH+A+  G AE++++L+ +GA VNA+     TPL+ A     
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61

Query: 153 LEVVKFLLDNGASQSLATEDGFTPLAVALQ----QGHDQVVSLLLENDTKGKVRLPALHI 208
            E V+ L+ + A  +   ++  TPL VA      +  + ++ LL   +   +    ALH 
Sbjct: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121

Query: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
           AA     +   LLL    N +   K     LH AA+ G+++V  LL+N  A V    +  
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181

Query: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
            TPLH A+  G  N+VK LL+ G +ID     G T LH    +G + VV  L+D  A + 
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241

Query: 329 SKTKNGLSPLHMATQGDH-LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLL 387
               NG +PLH A    H   C++LL+ +   V+  + D  + LH+ A  G +  ++ L+
Sbjct: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI 301

Query: 388 DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 447
                 +    +G TPLH+A +     ++  L   GA         + P+H+AA   H +
Sbjct: 302 QNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD 361

Query: 448 IVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISA 507
              +L+  G   +T +  G T LH AA  G  E ++ L   GA    K K  +TPLH +A
Sbjct: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421

Query: 508 RLGKADIVQQLLQQGASPNAATTSGYTPLHLS------------------------AREG 543
                  ++ L+  GA+ N     G T LH +                        ARE 
Sbjct: 422 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAREL 481

Query: 544 HEDVAA----FLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGL 599
            E  A     FLL + A+ SI  K+G+  +H AA YG  +   LLL+++ S      SG 
Sbjct: 482 KEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541

Query: 600 T--PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD- 656
           T  PLH+AA+  + +   +LL          + G T L +AA K   +    L+  GA  
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601

Query: 657 --ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN---VNLSNKSGLTPLHLAAQEDRVN 711
              + VT++    +H +   GH   + LLL    N   V++ +  G TPL LA     ++
Sbjct: 602 FVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659

Query: 712 VAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAA 771
              +L+ + A+VD    +G T LH G   G+ + V  LL+    +  K   G TPLH AA
Sbjct: 660 AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719

Query: 772 QQGHTHIINVLLQNNASPNELTVNGN 797
            +GH   ++ LLQ   S  +     N
Sbjct: 720 ARGHATWLSELLQMALSEEDCCFKDN 745



 Score =  267 bits (683), Expect = 2e-70
 Identities = 203/730 (27%), Positives = 336/730 (46%), Gaps = 39/730 (5%)

Query: 125 VLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQG 184
           +L+    +VN       TPL++AA     E+++ L+ +GA  +       TPL  A+   
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 185 HDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH 240
            ++ V +L+++    + + K     LH+AA     K A +++   ++ +V  + G T LH
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 241 IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD 300
            AA  G++ +  LLL + A ++   + D   LH A+  G+ ++V LL++ GA++  K + 
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180

Query: 301 GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPV 360
           G TPLH  A +G   VV+ LL+    I      G + LH+A        V  L+ +   V
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240

Query: 361 DDVTNDYLTALHVAAHCGHYKVA-KVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELL 419
           +   N+  T LH AA   H  +  ++L++  A+ N ++ +G +PLH+     R    + L
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300

Query: 420 LKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQA 479
           +++G  I  V + G TP+HVAA  GH  +++ L   GA      +     LH+AA +  +
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360

Query: 480 EVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLS 539
           +  R L+  G +++   K  +T LH +A  G  + ++ L   GA  +     G TPLH +
Sbjct: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420

Query: 540 AREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA----------------KYGKLEVA-- 581
           A   H      L+  GA+++ T   G T LH AA                   +LE A  
Sbjct: 421 AANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARE 480

Query: 582 ----------NLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631
                       LLQ  A+P    K G   +H AA Y +++   LLL++  S    + +G
Sbjct: 481 LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSG 540

Query: 632 YT--PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN 689
            T  PLH+AA          LL+   D +    +G  ++ LAA +GH + V  L+   A+
Sbjct: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600

Query: 690 VNL-SNKSGLTPLHLAAQEDRVNVAEVLV---NQGAHVDAQTKMGYTPLHVGCHYGNIKI 745
           + +  N +  TPLH +          +L+   +    VD +   G TPL +   YG+I  
Sbjct: 601 IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDA 660

Query: 746 VNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARR 805
           V+ LL+  A V+     G T LH+    GH   + +LL+   S       G T L  A  
Sbjct: 661 VSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAA 720

Query: 806 LGYISVVDTL 815
            G+ + +  L
Sbjct: 721 RGHATWLSEL 730



 Score =  203 bits (516), Expect = 3e-51
 Identities = 171/633 (27%), Positives = 274/633 (43%), Gaps = 55/633 (8%)

Query: 37  KKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVS----- 91
           +  D  +     A  G   ++   I+NG +I+  +++G   LH+A++ GH  +++     
Sbjct: 277 QSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTS 336

Query: 92  ----------------------------ELLQREANVDAATKKGNTALHIASLAGQAEVV 123
                                       +LL     +D   K G T LH A+  G  E +
Sbjct: 337 GADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECI 396

Query: 124 KVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQ 183
           K+L ++GA+ + + + G TPL+ AA   H   ++ L+  GA+ +   + G T L  A   
Sbjct: 397 KLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAAS 456

Query: 184 GHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAA 243
             D+    +L N       L        K+ T     LLQND N  +  K G+  +H AA
Sbjct: 457 DMDR-NKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAA 515

Query: 244 HYGNINVATLLLNRAAAVDFTARNDIT--PLHVASKRGNANMVKLLLDRGAKIDAKTRDG 301
            YG+     LLL R  +    + +  T  PLH+A+  G+   +++LL     +D +   G
Sbjct: 516 AYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKG 575

Query: 302 LTPLHCGARSGHEQVVEMLLDRAAPILSKTK-NGLSPLHMATQGDHLNCVQLLLQ----- 355
            T L   A  GH + VE L++  A I  K      +PLH +    H  C++LLL+     
Sbjct: 576 RTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNP 635

Query: 356 HNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKV 415
             V V D      T L +A   GH     +LL+K+AN +   + G T LH        + 
Sbjct: 636 EAVDVKDAKGQ--TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEEC 693

Query: 416 MELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT---TNVRGETALHM 472
           +++LL+   SI      G TP+H AA  GH   +S+L+    S       + +G T LH 
Sbjct: 694 VQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHW 753

Query: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATT-- 530
           A  +G    +  L++          +  TPLH +      +    LL  GA  ++  +  
Sbjct: 754 ACYNGNENCIEVLLEQKC-FRKFIGNPFTPLHCAIINDHGNCASLLL--GAIDSSIVSCR 810

Query: 531 --SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588
              G TPL  +A   H +    LL H A ++     G T L +AA+ G+    ++L+  +
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870

Query: 589 -ASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
            A      K   TPLH+A    ++K ALL+LD+
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903



 Score =  162 bits (410), Expect = 7e-39
 Identities = 154/565 (27%), Positives = 229/565 (40%), Gaps = 110/565 (19%)

Query: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
           AA   H +     + +G +I+  ++ G   LH A+  G+VE +  L    A+     K G
Sbjct: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413

Query: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA--------------QENHL 153
            T LH A+       ++ LVT GANVN     G T L+ AA               +N  
Sbjct: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE 473

Query: 154 EV--------------VKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKG 199
           E+              ++FLL N A+ S+  ++G+  +  A   GH Q + LLLE    G
Sbjct: 474 ELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSG 533

Query: 200 KVRLPA------LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATL 253
                +      LH+AA     +A  +LLQ+  + D+  + G T L +AA  G+      
Sbjct: 534 FEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEA 593

Query: 254 LLNRAA-------------------------------------AVDFTARNDITPLHVAS 276
           L+N  A                                     AVD       TPL +A 
Sbjct: 594 LINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAV 653

Query: 277 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS 336
             G+ + V LLL++ A +D     G T LH G  +GHE+ V+MLL++   IL K   G +
Sbjct: 654 AYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRT 713

Query: 337 PLHMATQGDHLNCVQLLLQHNVPVDDVT---NDYLTALHVAAHCGHYKVAKVLLDKKA-- 391
           PLH A    H   +  LLQ  +  +D     N   T LH A + G+    +VLL++K   
Sbjct: 714 PLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFR 773

Query: 392 ----NP-------------NAKAL---------------NGFTPLHIACKKNRIKVMELL 419
               NP             N  +L                G TPL  A   + ++ ++LL
Sbjct: 774 KFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLL 833

Query: 420 LKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG-ETALHMAARSGQ 478
           L+H A + AV  SG T + +AA  G    V  L++   +  T   +   T LH+A   G 
Sbjct: 834 LRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH 893

Query: 479 AEVVRYLVQDGAQVEAKAKDDQTPL 503
            E    L+ D  Q E+   +    L
Sbjct: 894 -EKCALLILDKIQDESLINEKNNAL 917


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  301 bits (770), Expect = 1e-80
 Identities = 188/571 (32%), Positives = 300/571 (52%), Gaps = 7/571 (1%)

Query: 225  DNNADVES--KSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNAN 282
            DN A V     +G T L  AA+ G+++V  LL++R A ++    +  TPL +A+++G+  
Sbjct: 533  DNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTK 592

Query: 283  MVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMAT 342
            +V  L+  GA I+   +DG T L   A  GH +VV  LL     +     +  + L  A 
Sbjct: 593  VVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAA 652

Query: 343  QGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFT 402
             G H + V  LLQH   V+   N+  TAL  AA+ GH ++ + LLD  A  N + ++G T
Sbjct: 653  WGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRT 712

Query: 403  PLHIAC-----KKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 457
             L +A       K    V+ LL+  GA +    + G+TP+ VAA+ GHV++V  L+  GA
Sbjct: 713  ALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGA 772

Query: 458  SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517
              + T+  G T L  AA  G A VV  L+  GA V++   + +T L I++  G  ++V+ 
Sbjct: 773  DVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRT 832

Query: 518  LLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGK 577
            LL +G   N    +G+TPLH++A EGH  +   L++ GA  +     G  P  +A++ G 
Sbjct: 833  LLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGH 892

Query: 578  LEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHI 637
             +   +LL+  ++ D  G  G   L VAA   ++ +  LL   GA  +    +G   L+I
Sbjct: 893  YDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYI 952

Query: 638  AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697
             A +NQ+ +A   LE GA+  A   +G  ++H++  +GH++MV +L+  +A+VN ++   
Sbjct: 953  LALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEK 1012

Query: 698  LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757
             + L  AA +  V V ++L+  GA VD     G T L +    G+I +V  LL+H A  N
Sbjct: 1013 RSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPN 1072

Query: 758  AKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788
               + G T +  AA+ GH+ II +L +  AS
Sbjct: 1073 HADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103



 Score =  288 bits (737), Expect = 8e-77
 Identities = 219/760 (28%), Positives = 343/760 (45%), Gaps = 51/760 (6%)

Query: 45   YLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAAT 104
            YL  A  GH   A+ Y     ++         ALHL +    +E     L    N     
Sbjct: 425  YLCNAAEGHRMLAMSYTCQAKNLTPLEAQEF-ALHLINSNLQLETAELALWMIWNGTPVR 483

Query: 105  KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
               +T +       + EV+++LV  GA+VN++       +  A +    + ++ LLDNGA
Sbjct: 484  DSLSTLI-----PKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGA 536

Query: 165  SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN 224
            S +    +G T LA A   G   VV+LL+                               
Sbjct: 537  SVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGA--------------------------- 569

Query: 225  DNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMV 284
              + ++E   G TPL +AA  G+  V   L+   A ++ T ++  T L  A+  G+  +V
Sbjct: 570  --DLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVV 627

Query: 285  KLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQG 344
              LL  G K+D    D  T L   A  GHE +V  LL   A +      G + L  A   
Sbjct: 628  SALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYM 687

Query: 345  DHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHC-----GHYKVAKVLLDKKANPNAKALN 399
             H   V+ LL H   V+    D  TAL VAA C     GH  V  +L+D+ A  +    +
Sbjct: 688  GHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKD 747

Query: 400  GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459
            G TPL +A  +  + V++LLL+ GA +     +G TP+  AA MGH ++V+ L+  GA+ 
Sbjct: 748  GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 807

Query: 460  NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519
            ++ +  G T L +A+  G  EVVR L+  G     +     TPLH++A  G   I + L+
Sbjct: 808  DSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALI 867

Query: 520  QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLE 579
            +QGA  N     G  P  L+++EGH D    LL++ +++      G   L VAA  G  +
Sbjct: 868  EQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRD 927

Query: 580  VANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639
            +  LL    A  +     G   L++ A  +   +A   L+ GA+  A+   G T LH++ 
Sbjct: 928  IVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSC 987

Query: 640  KKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLT 699
             +  M++   L+ Y AD NA   +  +++  AA +GHV +V LL+   A V+ +   G T
Sbjct: 988  WQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGAT 1047

Query: 700  PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAK 759
             L +AAQE  ++V +VL+  GA  +   + G T + V    G+ +I+  L     K  A 
Sbjct: 1048 ALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL----EKYGAS 1103

Query: 760  TKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTA 799
            + NG +P        HT     L   ++    LT+  N++
Sbjct: 1104 SLNGCSP-----SPVHTMEQKPLQSLSSKVQSLTIKSNSS 1138



 Score =  281 bits (719), Expect = 1e-74
 Identities = 190/567 (33%), Positives = 279/567 (49%), Gaps = 38/567 (6%)

Query: 254  LLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGH 313
            LL+  A+V+    N  T L  A+  G+ ++V LL+ RGA ++ +   G TPL   AR GH
Sbjct: 531  LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590

Query: 314  EQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHV 373
             +VV  L+   A I    ++G + L  A  G H   V  LL   V VD    D  TAL  
Sbjct: 591  TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650

Query: 374  AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
            AA  GH  +               LN                   LL+HGA +      G
Sbjct: 651  AAWGGHEDIV--------------LN-------------------LLQHGAEVNKADNEG 677

Query: 434  LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAA-----RSGQAEVVRYLVQD 488
             T +  AA+MGH  IV  L+ HGA  N  +V G TAL +AA       G A VV  L+  
Sbjct: 678  RTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR 737

Query: 489  GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548
            GA+V+   KD  TPL ++A  G  D+V  LL+ GA  +    +G TPL  +A  GH  V 
Sbjct: 738  GAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVV 797

Query: 549  AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHY 608
              LL  GA++     +G T L +A+  G +EV   LL +    +    +G TPLH+AA  
Sbjct: 798  NTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFE 857

Query: 609  DNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASV 668
             ++ +   L++QGA  +    +G  P  +A+++   D    LLE  ++ +     G  ++
Sbjct: 858  GHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNAL 917

Query: 669  HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 728
             +AA EGH D+V LL    A+VN  +  G   L++ A E+++ +AE  +  GA+V+A   
Sbjct: 918  RVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDA 977

Query: 729  MGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788
             G T LHV C  G++++V  L+ + A VNA      + L  AA QGH  ++ +L+++ A 
Sbjct: 978  EGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAV 1037

Query: 789  PNELTVNGNTALGIARRLGYISVVDTL 815
             +     G TAL IA + G+I VV  L
Sbjct: 1038 VDHTCNQGATALCIAAQEGHIDVVQVL 1064



 Score =  273 bits (698), Expect = 3e-72
 Identities = 178/562 (31%), Positives = 281/562 (50%), Gaps = 11/562 (1%)

Query: 40   DANASYL--RAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQRE 97
            D+N   L   AA +G L+     +  G D+ I + +G   L LA+++GH +VV+ L+   
Sbjct: 542  DSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCG 601

Query: 98   ANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVK 157
            AN++   + G TAL  A+  G  EVV  L+  G  V+    +  T L  AA   H ++V 
Sbjct: 602  ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVL 661

Query: 158  FLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN-------DTKGKVRLP--ALHI 208
             LL +GA  + A  +G T L  A   GH ++V  LL++       D  G+  L   AL +
Sbjct: 662  NLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCV 721

Query: 209  AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
             A K      +LL+      D   K G TPL +AA+ G+++V  LLL   A VD T  N 
Sbjct: 722  PASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNG 781

Query: 269  ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
             TPL  A+  G+A++V  LL  GA +D+   +G T L   +  G+ +VV  LLDR     
Sbjct: 782  RTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN 841

Query: 329  SKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLD 388
             +   G +PLHMA    H    + L++     +++ ND      +A+  GHY   ++LL+
Sbjct: 842  HRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE 901

Query: 389  KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448
             K+N + +  +G   L +A  +    ++ELL  HGA +      G   +++ A    + +
Sbjct: 902  NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTM 961

Query: 449  VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508
                + +GA+   ++  G TALH++   G  E+V+ L+   A V A   + ++ L  +A 
Sbjct: 962  AEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAW 1021

Query: 509  LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTP 568
             G   +VQ L++ GA  +     G T L ++A+EGH DV   LL+HGA  +   + G T 
Sbjct: 1022 QGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTA 1081

Query: 569  LHVAAKYGKLEVANLLLQKSAS 590
            + VAAK G  ++  LL +  AS
Sbjct: 1082 MRVAAKNGHSQIIKLLEKYGAS 1103



 Score =  236 bits (601), Expect = 5e-61
 Identities = 144/464 (31%), Positives = 241/464 (51%), Gaps = 15/464 (3%)

Query: 39   SDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREA 98
            +D+  +   AA  GH +  L+ +++G ++N  +  G  AL  A+  GH E+V  LL   A
Sbjct: 642  ADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGA 701

Query: 99   NVDAATKKGNTALHIASLA-----GQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHL 153
             V+     G TAL +A+L      G A VV +L+  GA V+   ++G TPL +AA E H+
Sbjct: 702  EVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHV 761

Query: 154  EVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL-------ENDTKGKVRLPAL 206
            +VV  LL+ GA       +G TPL  A   GH  VV+ LL         D++G+     L
Sbjct: 762  DVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRT---VL 818

Query: 207  HIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTAR 266
             IA+ + + +    LL    + +    +G+TPLH+AA  G+  +   L+ + A  +    
Sbjct: 819  SIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDN 878

Query: 267  NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326
            +   P  +AS+ G+ + V++LL+  + ID +  DG   L   A  GH  +VE+L    A 
Sbjct: 879  DGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGAD 938

Query: 327  ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
            +  K  +G   L++    + L   +  L++   V+    +  TALHV+   GH ++ +VL
Sbjct: 939  VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998

Query: 387  LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHV 446
            +   A+ NA      + L  A  +  +KV++LL++HGA +      G T + +AA  GH+
Sbjct: 999  IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHI 1058

Query: 447  NIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGA 490
            ++V  L+ HGA PN  +  G TA+ +AA++G +++++ L + GA
Sbjct: 1059 DVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102



 Score =  101 bits (252), Expect = 1e-20
 Identities = 74/261 (28%), Positives = 123/261 (47%), Gaps = 29/261 (11%)

Query: 32   SRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVS 91
            +R  +  +D    ++ A++ GH +     ++N  +I+    +G NAL +A+ EGH ++V 
Sbjct: 871  ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVE 930

Query: 92   ELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQEN 151
             L    A+V+     G   L+I +L  Q  + +  + NGANV A    G T L+++  + 
Sbjct: 931  LLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQG 990

Query: 152  HLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAAR 211
            H+E+V+ L+   A  + A  +  + L  A  QGH +VV LL+E+   G V          
Sbjct: 991  HMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEH---GAV---------- 1037

Query: 212  KDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITP 271
                             D     G T L IAA  G+I+V  +LL   A  +   +   T 
Sbjct: 1038 ----------------VDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTA 1081

Query: 272  LHVASKRGNANMVKLLLDRGA 292
            + VA+K G++ ++KLL   GA
Sbjct: 1082 MRVAAKNGHSQIIKLLEKYGA 1102


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  291 bits (746), Expect = 7e-78
 Identities = 235/797 (29%), Positives = 360/797 (45%), Gaps = 42/797 (5%)

Query: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
           A  +GHLE     +  G  +N+C++     LH A+  GH+EV+  L+ R A++    +KG
Sbjct: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206

Query: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
              LH A+ +GQ EVVK L+  GA ++  +  G T L++A       V   L++ GA+ +
Sbjct: 207 YGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266

Query: 168 LATEDGFTPLAVALQQGHDQVVSLLLEN-----DTKGKVRLPALHIAARKDDTKAAALLL 222
              + GFTPL VA    +  +   LL N     + + K     LH+AA       + +L+
Sbjct: 267 QPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 326

Query: 223 QNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNAN 282
           QN +  D   K G TPLH+AA YG+  + + L+   A       +D+ PLH+A   G ++
Sbjct: 327 QNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSD 386

Query: 283 MVKLLLDRG----------------AKIDAKTRD--GLTPLHCGARSGHEQVVEMLLDRA 324
             + LL  G                A  D  T D  G T LH  A  G+ + + +LL   
Sbjct: 387 CCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSG 446

Query: 325 APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAK 384
           A +  + K G +PLH A       C   L+     V++      + LH AA    Y+ A 
Sbjct: 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRA- 505

Query: 385 VLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMG 444
               +   P++       PL  + +K     +E LL +GA        G T +H AA  G
Sbjct: 506 ----EPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYG 561

Query: 445 HVNIVSQL--MHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502
           +   +  L  M      +  +    + LH+AA +G  E ++ L +    ++ +    +T 
Sbjct: 562 NRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTA 621

Query: 503 LHISARLGKADIVQQLLQQGASPNAATTS-GYTPLHLSAREGHEDVAAFLLDHGASLSIT 561
           L ++   G  + V+ L   GAS         +TPLH +A  GH D    L+D G    IT
Sbjct: 622 LFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADIT 681

Query: 562 ---TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618
                 G TPL +A   G ++  +LLL+K ++ DAA   G T LH  A    +     LL
Sbjct: 682 DVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALL 741

Query: 619 DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN----AVTRQGIASVHLAAQE 674
           D  A        G TP+H+A+      +  TLL+     +     V   G + +H A+  
Sbjct: 742 DHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYT 801

Query: 675 GHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQ-GAH-VDAQTKMGYT 732
           GH D + LLL  ++  +    +  TPLH A   ++ +  E+L+   GA  V+++   G T
Sbjct: 802 GHEDCLELLL-EHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRT 860

Query: 733 PLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL-QNNASPNE 791
           PLH      N+  +  LLQH A+VNA    G T L  AA+ G T  +  LL +  A    
Sbjct: 861 PLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTV 920

Query: 792 LTVNGNTALGIARRLGY 808
           L  N NTAL +A   G+
Sbjct: 921 LDENKNTALHLACSKGH 937



 Score =  288 bits (736), Expect = 1e-76
 Identities = 240/818 (29%), Positives = 360/818 (44%), Gaps = 68/818 (8%)

Query: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
           AA  GHLE     +  G D+   ++ G   LH A+  G +EVV  LL+  A +D     G
Sbjct: 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFG 239

Query: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA-QENHLEVVKFLLDNGASQ 166
           NTALHIA   GQ  V   LV  GANVN  +  GFTPL++AA   N    ++ L++NGA  
Sbjct: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299

Query: 167 SLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLL 222
           +  +++G +PL +A   G      +L++N    D   K     LH+AAR       + L+
Sbjct: 300 NYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359

Query: 223 QNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR----------------AAAVDFTAR 266
            N  +          PLH+A  +G  +    LL+                 +A  D    
Sbjct: 360 TNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTP 419

Query: 267 NDI--TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
           +++  T LH A+  GN   + LLL  GA +  + + G TPLH  A +G  Q    L+   
Sbjct: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479

Query: 325 APILSKTKNGLSPLHMATQGDHLN----------------------------CVQLLLQH 356
           A +      G SPLH A   D                               C++ LL +
Sbjct: 480 AGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDN 539

Query: 357 NVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN--PNAKALNGFTPLHIACKKNRIK 414
                       TA+H AA  G+ +  ++LL+   N   + ++    +PLH+A      +
Sbjct: 540 GADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCE 599

Query: 415 VMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE-TALHMA 473
            ++ L +   ++      G T + +A   G    V  L  HGAS      + + T LH A
Sbjct: 600 ALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAA 659

Query: 474 ARSGQAEVVRYLVQDGAQVEAKAKDD---QTPLHISARLGKADIVQQLLQQGASPNAATT 530
           A SG  + +  L+  G + +     D   QTPL ++   G  D V  LL++G++ +AA  
Sbjct: 660 AASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADL 719

Query: 531 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS 590
            G T LH  A  G ED  A LLDH A +     KG TP+H+A+  G   V   LLQ + S
Sbjct: 720 RGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALS 779

Query: 591 PD----AAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDI 646
            D        SG +P+H A++  ++    LLL+     +    N +TPLH A   NQ   
Sbjct: 780 TDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEG-NPFTPLHCAVINNQDST 838

Query: 647 ATTLL-EYGAD-ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLA 704
              LL   GA   N+   +G   +H AA   +V  + +LL   A VN ++ +G T L  A
Sbjct: 839 TEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTA 898

Query: 705 AQEDRVNVAEVLVNQG-AHVDAQTKMGYTPLHVGCHYGNIKIVNFLL---QHSAKVNAKT 760
           A+  +    E L+ +G A +    +   T LH+ C  G+ K    +L   Q    +NA  
Sbjct: 899 AENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATN 958

Query: 761 KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNT 798
                PLH AA+ G   ++  LL + A+   +   G+T
Sbjct: 959 SALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHT 996



 Score =  275 bits (703), Expect = 7e-73
 Identities = 228/779 (29%), Positives = 348/779 (44%), Gaps = 56/779 (7%)

Query: 54  LEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHI 113
           +E+    +    +IN+ +Q     LH A+  G V ++  LL   ANV+A      T LH 
Sbjct: 21  VEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHR 80

Query: 114 ASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDG 173
           A+ +   +V+ +L+ + A+VNA+ +   TPL++AA     +  + L    +S ++A   G
Sbjct: 81  AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSG 140

Query: 174 FTPLAVALQQGHDQVVSLLLE-----NDTKGKVRLPALHIAARKDDTKAAALLLQNDNNA 228
            + L  A+  GH + V+LLL      N    K R P LH AA     +   LL+    + 
Sbjct: 141 RSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP-LHWAAFLGHLEVLKLLVARGADL 199

Query: 229 DVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLL 288
             + + G+  LH AA  G I V   LL   A +D       T LH+A   G   +   L+
Sbjct: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV 259

Query: 289 DRGAKIDAKTRDGLTPLHCGARSGHEQV-VEMLLDRAAPILSKTKNGLSPLHMATQGDHL 347
           + GA ++     G TPLH  A S +  + +E+L++  A +  ++K G SPLHMA      
Sbjct: 260 NAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRF 319

Query: 348 NCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIA 407
              Q+L+Q+   +D       T LHVAA  GH  +   L+   A+   + ++   PLH+A
Sbjct: 320 TRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLA 379

Query: 408 CKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE 467
                      LL  G     V  S L+  HV             +  G   NT +  G 
Sbjct: 380 VLFGFSDCCRKLLSSGQLYSIV--SSLSNEHV-------------LSAGFDINTPDNLGR 424

Query: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527
           T LH AA  G  E +  L+  GA +  + K  +TPLH +A  G       L+  GA  N 
Sbjct: 425 TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 484

Query: 528 ATTSGYTPLHL---------------SAREGHED-------------VAAFLLDHGASLS 559
           A   G +PLH                S+ +  ED                FLLD+GA  S
Sbjct: 485 ADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544

Query: 560 ITTKKGFTPLHVAAKYGKLEVANLLLQKSAS--PDAAGKSGLTPLHVAAHYDNQKVALLL 617
           +  ++G+T +H AA YG  +   LLL+ S +   D      ++PLH+AA+  + +    L
Sbjct: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL 604

Query: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTR-QGIASVHLAAQEGH 676
            +   +       G T L +A ++   +    L  +GA A    R +    +H AA  GH
Sbjct: 605 AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGH 664

Query: 677 VDMVSLLL--GRNANV-NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTP 733
            D + LL+  G  A++ ++ +  G TPL LA     V+   +L+ +G+  DA    G T 
Sbjct: 665 TDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTA 724

Query: 734 LHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 792
           LH G   G    +  LL H A V  +   G TP+H A+  GHT ++  LLQ   S + L
Sbjct: 725 LHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPL 783



 Score =  267 bits (683), Expect = 2e-70
 Identities = 207/705 (29%), Positives = 319/705 (45%), Gaps = 40/705 (5%)

Query: 143 PLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTK 198
           PL  A     +E V+ LL    + ++  ++  TPL  A   G   ++ LLL +    + K
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 199 GKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRA 258
             + L  LH AA   + K   LLL +  + +   K   TPLH+AA       A  L    
Sbjct: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130

Query: 259 AAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVE 318
           ++++   R+  + LH A   G+   V LLL++GA ++   +    PLH  A  GH +V++
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190

Query: 319 MLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCG 378
           +L+ R A +  K + G   LH A     +  V+ LL+    +D+      TALH+A + G
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250

Query: 379 HYKVAKVLLDKKANPNAKALNGFTPLHIAC-KKNRIKVMELLLKHGASIQAVTESGLTPI 437
              VA  L++  AN N     GFTPLH+A    N    +ELL+ +GA +   ++ G +P+
Sbjct: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310

Query: 438 HVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAK 497
           H+AA  G       L+ +G+  +  +  G T LH+AAR G   ++  L+ +GA    +  
Sbjct: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGI 370

Query: 498 DDQTPLHISARLGKADIVQQLLQQGA------------------SPNAATTSGYTPLHLS 539
            D  PLH++   G +D  ++LL  G                     N     G T LH +
Sbjct: 371 HDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAA 430

Query: 540 AREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGL 599
           A  G+ +    LL  GA L    K G TPLH AA  G  + A  L+   A  + A   G 
Sbjct: 431 ASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGC 490

Query: 600 TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGY---TPLHIAAKKNQMDIATTLLEYGAD 656
           +PLH AA  D  +         A PH  + +      PL  + +K        LL+ GAD
Sbjct: 491 SPLHYAAASDTYR--------RAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGAD 542

Query: 657 ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV--NLSNKSGLTPLHLAAQEDRVNVAE 714
            +   RQG  +VH AA  G+   + LLL  + N   ++ +   ++PLHLAA        +
Sbjct: 543 PSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALK 602

Query: 715 VLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAK-TKNGYTPLHQAAQQ 773
            L     ++D +   G T L +    G+ + V  L  H A    K  K  +TPLH AA  
Sbjct: 603 TLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS 662

Query: 774 GHTHIINVLLQNNAS---PNELTVNGNTALGIARRLGYISVVDTL 815
           GHT  +++L+ +       + +   G T L +A   G++  V  L
Sbjct: 663 GHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707



 Score =  258 bits (658), Expect = 1e-67
 Identities = 204/717 (28%), Positives = 326/717 (45%), Gaps = 56/717 (7%)

Query: 61  IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA 120
           + NG D+N  ++ G + LH+A+  G       L+Q  + +D A K GNT LH+A+  G  
Sbjct: 293 VNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHE 352

Query: 121 EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180
            ++  L+TNGA+   +  +   PL++A      +  + LL +G   S+ +          
Sbjct: 353 LLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSS--------- 403

Query: 181 LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH 240
               ++ V+S   + +T   +    LH AA   + +   LLL +  +     K G TPLH
Sbjct: 404 --LSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLH 461

Query: 241 IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVA------------------------- 275
            AA  G+   A  L+   A V+       +PLH A                         
Sbjct: 462 YAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPL 521

Query: 276 --SKRGNANM-VKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTK 332
             S+R  A   ++ LLD GA    + R G T +H  A  G+ Q +E+LL+ +   L   +
Sbjct: 522 KESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVE 581

Query: 333 NGL--SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKK 390
           + +  SPLH+A    H   ++ L +  V +D   +   TAL +A   G  +  +VL    
Sbjct: 582 STIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHG 641

Query: 391 ANPNAKALNG-FTPLHIACKKNRIKVMELLLKHG--ASIQAVTES-GLTPIHVAAFMGHV 446
           A+   K     +TPLH A        + LL+  G  A I  V ++ G TP+ +A   GHV
Sbjct: 642 ASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHV 701

Query: 447 NIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS 506
           + V  L+  G++ +  ++RG TALH  A +G  + +  L+   A V  +    +TP+H++
Sbjct: 702 DCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLA 761

Query: 507 ARLGKADIVQQLLQQGASPNAATT----SGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562
           +  G   +++ LLQ   S +        SGY+P+H ++  GHED    LL+H +  S   
Sbjct: 762 SACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLE 820

Query: 563 KKGFTPLHVAAKYGKLEVANLLLQKSASP--DAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
              FTPLH A    +     +LL    +   ++    G TPLH AA  DN     +LL  
Sbjct: 821 GNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQH 880

Query: 621 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG-ADANAVTRQGIASVHLAAQEGHVDM 679
            A  +A    G T L  AA+  Q      LL  G AD   +      ++HLA  +GH   
Sbjct: 881 QAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKC 940

Query: 680 VSLLLGRNAN---VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTP 733
             ++L    +   +N +N +   PLH+AA+    +V + L++ GA V A  + G+TP
Sbjct: 941 ALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997



 Score =  239 bits (611), Expect = 3e-62
 Identities = 168/564 (29%), Positives = 263/564 (46%), Gaps = 47/564 (8%)

Query: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327
           D  PL  A    +   V+ LL +   I+   ++  TPLH  A  G   ++++LL   A +
Sbjct: 8   DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67

Query: 328 LSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLL 387
            +K    L+PLH A    +   + LLL H+  V+     + T LHVAA     K A+ L 
Sbjct: 68  NAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALA 127

Query: 388 DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 447
              ++ N    +G + LH A     ++ + LLL  GAS+    +    P+H AAF+GH+ 
Sbjct: 128 PLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLE 187

Query: 448 IVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISA 507
           ++  L+  GA     + +G   LH AA SGQ EVV+YL++ GA+++       T LHI+ 
Sbjct: 188 VLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIAC 247

Query: 508 RLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA-AFLLDHGASLSITTKKGF 566
            LG+  +  +L+  GA+ N     G+TPLH++A   +  +    L+++GA ++  +K+G 
Sbjct: 248 YLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGK 307

Query: 567 TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626
           +PLH+AA +G+   + +L+Q  +  D A K G TPLHVAA Y ++ +   L+  GA    
Sbjct: 308 SPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTAR 367

Query: 627 AAKNGYTPLHIAAKKNQMDIATTLLEYGA------------------DANAVTRQGIASV 668
              +   PLH+A      D    LL  G                   D N     G   +
Sbjct: 368 RGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCL 427

Query: 669 HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 728
           H AA  G+V+ ++LLL   A++   +K G TPLH AA       A  LV  GA V+    
Sbjct: 428 HAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADC 487

Query: 729 MGYTPLHVGCHYGNIK----------------------------IVNFLLQHSAKVNAKT 760
            G +PLH        +                             + FLL + A  + + 
Sbjct: 488 KGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRD 547

Query: 761 KNGYTPLHQAAQQGHTHIINVLLQ 784
           + GYT +H AA  G+   + +LL+
Sbjct: 548 RQGYTAVHYAAAYGNRQNLELLLE 571



 Score =  209 bits (531), Expect = 6e-53
 Identities = 195/670 (29%), Positives = 281/670 (41%), Gaps = 125/670 (18%)

Query: 64   GVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVV 123
            G DIN  +  G   LH A+  G+VE ++ LL   A++    K G T LH A+  G  +  
Sbjct: 413  GFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCA 472

Query: 124  KVLVTNGANVNAQSQNGFTPLYMAAQENHLE----------------------------V 155
              LVT GA VN     G +PL+ AA  +                                
Sbjct: 473  VTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFC 532

Query: 156  VKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE------NDTKGKVRLPALHIA 209
            ++FLLDNGA  SL    G+T +  A   G+ Q + LLLE       D +  + +  LH+A
Sbjct: 533  LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592

Query: 210  ARKDDTKAAALLLQNDNNADV----------------------------------ESKSG 235
            A     +A   L +   N DV                                  E K  
Sbjct: 593  AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK 652

Query: 236  FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDI---TPLHVASKRGNANMVKLLLDRGA 292
            +TPLH AA  G+ +   LL++     D T   D    TPL +A   G+ + V LLL++G+
Sbjct: 653  WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712

Query: 293  KIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQL 352
              DA    G T LH GA +G E  +  LLD  A +L +   G +P+H+A+   H   ++ 
Sbjct: 713  TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772

Query: 353  LLQHNVPVD--DVTNDY--LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIAC 408
            LLQ  +  D  D   DY   + +H A++ GH    ++LL+       +  N FTPLH A 
Sbjct: 773  LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEG-NPFTPLHCAV 831

Query: 409  KKNRIKVMELLLKH-GASIQAVTES-GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466
              N+    E+LL   GA I    ++ G TP+H AAF  +V+ +  L+ H A  N T+  G
Sbjct: 832  INNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTG 891

Query: 467  ETALHMAARSGQAEVVRYLV-------------------------------------QDG 489
             TAL  AA +GQ   V +L+                                     QD 
Sbjct: 892  RTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951

Query: 490  AQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAA 549
              + A     Q PLHI+AR G A +VQ LL  GA+  A    G+TP    A   ++DVA 
Sbjct: 952  GLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA--PNKDVAD 1009

Query: 550  FLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYD 609
             L     +L ++T K F P    + +    + N  +   A+    G  G  P   +  Y 
Sbjct: 1010 CL-----ALILSTMKPFPPKDAVSPFSFSLLKNCSI---AAAKTVGGCGALPHGASCPYS 1061

Query: 610  NQKVALLLLD 619
             ++   + LD
Sbjct: 1062 QERPGAIGLD 1071



 Score =  185 bits (470), Expect = 8e-46
 Identities = 122/354 (34%), Positives = 179/354 (50%), Gaps = 1/354 (0%)

Query: 463 NVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG 522
           ++  +  L  A  S   E VR L+     +    ++ +TPLH +A +G   I+Q LL  G
Sbjct: 5   SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSG 64

Query: 523 ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVAN 582
           A+ NA  T   TPLH +A   +E V   LL H A ++   K   TPLHVAA     + A 
Sbjct: 65  ANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAE 124

Query: 583 LLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN 642
            L    +S + A +SG + LH A H  + +   LLL++GAS +   K    PLH AA   
Sbjct: 125 ALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLG 184

Query: 643 QMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLH 702
            +++   L+  GAD     R+G   +H AA  G +++V  LL   A ++  N  G T LH
Sbjct: 185 HLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALH 244

Query: 703 LAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKI-VNFLLQHSAKVNAKTK 761
           +A    +  VA  LVN GA+V+     G+TPLHV     N  + +  L+ + A VN ++K
Sbjct: 245 IACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSK 304

Query: 762 NGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
            G +PLH AA  G      +L+QN +  +     GNT L +A R G+  ++ TL
Sbjct: 305 EGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  242 bits (618), Expect = 5e-63
 Identities = 142/402 (35%), Positives = 215/402 (53%), Gaps = 2/402 (0%)

Query: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
           +N ++PLH       +  V+LLL H V VD  T    T L +AA      +  +LL   A
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQ 451
           + N    +G+ PLH A +        LLL HGA + A    G TP+H+AA     N+   
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479

Query: 452 LMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGK 511
           L+   A PN     G+T LH+AA  G   +V+ L   GA+++A+ ++ +TPLH++   GK
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539

Query: 512 ADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHV 571
              +Q LL+ GA P+A   SGY PLH +A  G   +   LL +GASL + T +G+TPLH+
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599

Query: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631
           AA  G LE+ +LL +  A+  A G    TPLH+AA +  + V   LL  GA P+AA ++G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659

Query: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691
           +TPLH+A +++       LLE+ A+ +A  + G    HLAA +G+  ++ +L+   A ++
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719

Query: 692 LSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTP 733
           + +    TPL LA +  +  +   L  +G      T  G  P
Sbjct: 720 VQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759



 Score =  229 bits (583), Expect = 6e-59
 Identities = 145/450 (32%), Positives = 232/450 (51%), Gaps = 11/450 (2%)

Query: 185 HDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAH 244
           ++ +   L+++D+ G     AL ++ RK+      L+ +++     E+K   TPLH    
Sbjct: 321 NEDISQELMDSDS-GNYLKRALQLSDRKN------LVPRDEELCIYENK--VTPLHFLVA 371

Query: 245 YGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTP 304
            G++    LLL     VD    +  TPL +A++    ++  LLL  GA  +    DG  P
Sbjct: 372 QGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431

Query: 305 LHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT 364
           LH  A++G +    +LLD  A + ++ + G +PLH+A Q +  N  +LL+      +   
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491

Query: 365 NDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGA 424
            +  T LHVAA+ GH  + K+L  + A  +A+  N  TPLH+A ++ +++ ++ LLK GA
Sbjct: 492 AEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGA 551

Query: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
              A+ +SG  P+H AA  G   I   L+ +GAS      +G T LH+AA  G  E++  
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611

Query: 485 LVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGH 544
           L +  A + A    + TPLH++AR G+  +V  LLQ GA PNAA  SG+TPLHL+ +   
Sbjct: 612 LAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRST 671

Query: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
                 LL+H A++    K G+TP H+AA  G   +  +L++  A  D       TPL +
Sbjct: 672 FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731

Query: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTP 634
           A    ++K  ++   +G  P  A   G  P
Sbjct: 732 ALR--SRKQGIMSFLEGKEPSVATLGGSKP 759



 Score =  222 bits (565), Expect = 7e-57
 Identities = 135/399 (33%), Positives = 204/399 (51%), Gaps = 2/399 (0%)

Query: 399 NGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS 458
           N  TPLH    +  ++ + LLL H   +   T SG TP+ +AA     ++ + L+ HGA 
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420

Query: 459 PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQL 518
            N  +  G   LH AA++G     R L+  GA V+A+ ++  TPLH++A+    ++ + L
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480

Query: 519 LQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKL 578
           + + A PN     G TPLH++A  GH  +   L   GA L    +   TPLH+A + GK+
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540

Query: 579 EVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638
                LL+  A PDA  +SG  PLH AA      +  +LL  GAS       G+TPLH+A
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600

Query: 639 AKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL 698
           A K  ++I   L E  A+  A+       +HLAA+ G   +VS LL   A+ N + +SG 
Sbjct: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660

Query: 699 TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758
           TPLHLA Q         L+   A+V A+ K+G+TP H+    GN  I+  L++  A+++ 
Sbjct: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720

Query: 759 KTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN 797
           +     TPL  A +     I++ L      P+  T+ G+
Sbjct: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGS 757



 Score =  220 bits (560), Expect = 3e-56
 Identities = 135/389 (34%), Positives = 200/389 (51%)

Query: 302 LTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD 361
           +TPLH     G  + V +LL     +  +T +G +PL +A Q    +   LLL H    +
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 362 DVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLK 421
            V  D    LH AA  G    A++LLD  A  +A+   G+TPLH+A + N   V  LL+ 
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482

Query: 422 HGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEV 481
             A        G TP+HVAA+ GHV++V  L   GA  +       T LH+A   G+   
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542

Query: 482 VRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAR 541
           +++L++ GA  +A  +    PLH +A  GK  I + LL+ GAS    T  G+TPLHL+A 
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY 602

Query: 542 EGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTP 601
           +GH ++   L +  A++       +TPLH+AA++G+  V + LLQ  A P+AA +SG TP
Sbjct: 603 KGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662

Query: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
           LH+A         + LL+  A+ HA  K G+TP H+AA K    I   L+E GA  +   
Sbjct: 663 LHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722

Query: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANV 690
                 + LA +     ++S L G+  +V
Sbjct: 723 GVSCTPLQLALRSRKQGIMSFLEGKEPSV 751



 Score =  218 bits (556), Expect = 8e-56
 Identities = 129/359 (35%), Positives = 188/359 (52%)

Query: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488
           + E+ +TP+H     G V  V  L+ H    +     G T L +AA+  Q ++   L+  
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417

Query: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548
           GA      +D   PLH +A+ G     + LL  GA  +A    G+TPLHL+A+   E+VA
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477

Query: 549 AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHY 608
             L+   A  ++   +G TPLHVAA +G + +  LL  + A  DA  ++  TPLH+A   
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537

Query: 609 DNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASV 668
              +    LL  GA P A  ++GY PLH AA + +  I   LL YGA     T QG   +
Sbjct: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597

Query: 669 HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 728
           HLAA +GH++++ LL   +AN+        TPLHLAA+     V   L+  GA  +A  +
Sbjct: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657

Query: 729 MGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNA 787
            G+TPLH+         V  LL+H A V+A+ K G+TP H AA +G+T I+ VL++  A
Sbjct: 658 SGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA 716



 Score =  215 bits (547), Expect = 9e-55
 Identities = 135/395 (34%), Positives = 198/395 (50%), Gaps = 3/395 (0%)

Query: 358 VPVDD---VTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIK 414
           VP D+   +  + +T LH     G  +  ++LL  + + + +  +G+TPL IA +  +  
Sbjct: 350 VPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPD 409

Query: 415 VMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAA 474
           +  LLL HGA    V E G  P+H AA  G       L+ HGA  +     G T LH+AA
Sbjct: 410 LCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA 469

Query: 475 RSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYT 534
           ++    V R LV   A       + +TPLH++A  G   +V+ L  QGA  +A   +  T
Sbjct: 470 QNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRT 529

Query: 535 PLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAA 594
           PLHL+   G       LL  GA      + G+ PLH AA  GK  +  +LL+  AS +  
Sbjct: 530 PLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP 589

Query: 595 GKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 654
              G TPLH+AA+  + ++  LL +  A+  A     +TPLH+AA+  +  + + LL+ G
Sbjct: 590 THQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCG 649

Query: 655 ADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAE 714
           AD NA  + G   +HLA Q      V  LL  +ANV+  NK G TP HLAA +    + +
Sbjct: 650 ADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILK 709

Query: 715 VLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749
           VLV  GA +D Q  +  TPL +        I++FL
Sbjct: 710 VLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score =  210 bits (535), Expect = 2e-53
 Identities = 147/475 (30%), Positives = 231/475 (48%), Gaps = 40/475 (8%)

Query: 22  PEKKRKHRKRS------RDRKKKSDANASYLRAARAGHLEKALDYI--KNGV--DINIC- 70
           PE K   RK S      +  +   D +   + +    +L++AL     KN V  D  +C 
Sbjct: 299 PESKALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCI 358

Query: 71  NQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNG 130
            +N +  LH    +G VE V  LL  E +VD  T  G T L IA+   Q ++  +L+ +G
Sbjct: 359 YENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHG 418

Query: 131 ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190
           A+ N   ++G+ PL+ AAQ       + LLD+GA       +G+TP              
Sbjct: 419 ADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTP-------------- 464

Query: 191 LLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINV 250
                          LH+AA+ +    A LL+    + ++    G TPLH+AA++G++++
Sbjct: 465 ---------------LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSL 509

Query: 251 ATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGAR 310
             LL ++ A +D   RN  TPLH+A +RG    ++ LL  GA  DA  + G  PLH  A 
Sbjct: 510 VKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAA 569

Query: 311 SGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTA 370
            G   + +MLL   A +   T  G +PLH+A    HL  + LL + +  +  +     T 
Sbjct: 570 RGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTP 629

Query: 371 LHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430
           LH+AA  G   V   LL   A+PNA   +G+TPLH+A +++    +  LL+H A++ A  
Sbjct: 630 LHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN 689

Query: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
           + G TP H+AA  G+  I+  L+  GA  +  +    T L +A RS +  ++ +L
Sbjct: 690 KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score =  207 bits (528), Expect = 1e-52
 Identities = 125/384 (32%), Positives = 190/384 (49%)

Query: 267 NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326
           N +TPLH    +G+   V+LLL     +D +T  G TPL   A+     +  +LL   A 
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420

Query: 327 ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
                ++G +PLH A Q       +LLL H   VD    +  T LH+AA      VA++L
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480

Query: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHV 446
           + ++A+PN     G TPLH+A     + +++LL   GA + A   +  TP+H+A   G V
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540

Query: 447 NIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS 506
             +  L+  GA P+  +  G   LH AA  G+  + + L++ GA +E       TPLH++
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600

Query: 507 ARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGF 566
           A  G  +I+  L +  A+  A     +TPLHL+AR G E V + LL  GA  +   + G+
Sbjct: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660

Query: 567 TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626
           TPLH+A +         LL+  A+  A  K G TP H+AA   N  +  +L++ GA    
Sbjct: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720

Query: 627 AAKNGYTPLHIAAKKNQMDIATTL 650
                 TPL +A +  +  I + L
Sbjct: 721 QDGVSCTPLQLALRSRKQGIMSFL 744



 Score =  136 bits (342), Expect = 5e-31
 Identities = 80/209 (38%), Positives = 111/209 (53%)

Query: 599 LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN 658
           +TPLH      + +   LLL           +GYTPL IAA+  Q D+   LL +GADAN
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 659 AVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVN 718
            V   G A +H AAQ G      LLL   A V+   + G TPLHLAAQ +  NVA +LV+
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482

Query: 719 QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI 778
           + A  +     G TPLHV  ++G++ +V  L    A+++A+ +N  TPLH A ++G    
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542

Query: 779 INVLLQNNASPNELTVNGNTALGIARRLG 807
           I  LL++ A P+ L  +G   L  A   G
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARG 571



 Score =  112 bits (280), Expect = 8e-24
 Identities = 76/262 (29%), Positives = 126/262 (48%), Gaps = 8/262 (3%)

Query: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
           AA  GH+         G +++   +N    LHLA + G V  +  LL+  A  DA  + G
Sbjct: 501 AAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSG 560

Query: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
              LH A+  G+  + K+L+  GA++   +  G+TPL++AA + HLE++  L ++ A+  
Sbjct: 561 YGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMG 620

Query: 168 LATEDGFTPLAVALQQGHDQVVSLLLE-----NDTKGKVRLPALHIAARKDDTKAAALLL 222
                 +TPL +A + G + VVS LL+     N  +     P LH+A ++    +   LL
Sbjct: 621 ALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP-LHLAVQRSTFLSVINLL 679

Query: 223 QNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNAN 282
           ++  N    +K G+TP H+AA  GN  +  +L+   A +D       TPL +A +     
Sbjct: 680 EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQG 739

Query: 283 MVKLLLDRGAKIDAKTRDGLTP 304
           ++  L   G +    T  G  P
Sbjct: 740 IMSFL--EGKEPSVATLGGSKP 759



 Score =  102 bits (254), Expect = 8e-21
 Identities = 59/187 (31%), Positives = 88/187 (47%)

Query: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA 688
           +N  TPLH    +  ++    LL +  D +  T  G   + +AAQ+   D+ +LLL   A
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNF 748
           + N  ++ G  PLH AAQ      A +L++ GA VDAQ + G+TPLH+        +   
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479

Query: 749 LLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGY 808
           L+   A  N     G TPLH AA  GH  ++ +L    A  +    N  T L +A   G 
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539

Query: 809 ISVVDTL 815
           +  +  L
Sbjct: 540 VRAIQHL 546


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  232 bits (592), Expect = 5e-60
 Identities = 165/486 (33%), Positives = 255/486 (52%), Gaps = 12/486 (2%)

Query: 312 GHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDD--VTNDYLT 369
           G    V  LL     +   T+ G S L +A    +    Q+LL  +  V+D  +  D +T
Sbjct: 245 GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD-IT 303

Query: 370 ALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429
            L  AA+ GH K+ K+LL  KA+ NA++  G T L  AC    + V+++LL+ GASI+  
Sbjct: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH 363

Query: 430 TESGLTPIHVAAFMGHVNIVSQLMHHGASPNT-TNVRGETALHMAARSGQAEVVRYLVQD 488
            E+G TP+  A   GHV +   L+ +GA  NT +N   E+AL +A   G  E+VR+L++ 
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA 423

Query: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548
           GA  E K  +  T L  +   G  ++ + LL  GA  N    S  +PL L+A  GH ++A
Sbjct: 424 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 483

Query: 549 AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA-AGKSGLTPLHVAAH 607
           A L++ GASL     +G+TPL  AA+ G  E+  LLL + A+ +A   ++  T L +A  
Sbjct: 484 ALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACC 543

Query: 608 YDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIAS 667
               +VA  L+  GA          TPL  AA++  +++   LL  GA+ +A T  G  +
Sbjct: 544 GGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600

Query: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727
           +  A + GH D+  +LL   A++   ++ G TPL  AA+   V   + L+++GA+V+  T
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660

Query: 728 KMG-YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNN 786
               +T L + C  G++ +V  LL H A    + K+G T L +AA+ GHT ++  LL   
Sbjct: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD-- 718

Query: 787 ASPNEL 792
             PN L
Sbjct: 719 -YPNNL 723



 Score =  229 bits (585), Expect = 3e-59
 Identities = 162/510 (31%), Positives = 264/510 (51%), Gaps = 18/510 (3%)

Query: 317 VEMLLDRAAPILSKTK----------NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTND 366
           V   LD AA  L++ +          +  S     ++GD +N V+ LL     V++ T +
Sbjct: 208 VSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGD-VNAVRKLLIEGRSVNEHTEE 266

Query: 367 YLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG-FTPLHIACKKNRIKVMELLLKHGAS 425
             + L +A   G+Y++A+VLL   AN   + + G  TPL  A     +K+++LLL H A 
Sbjct: 267 GESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKAD 326

Query: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
           + A + +G T +  A   G+V++V  L+  GAS    N  G T L  A  +G  EV R L
Sbjct: 327 VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386

Query: 486 VQDGAQVEAKAKD-DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGH 544
           +++GA +   + +  ++ L ++   G  ++V+ LL+ GA     T   +T L  +  +GH
Sbjct: 387 LENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH 446

Query: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
            +VA  LLD GA +++      +PL +AA  G +E+A LL+++ AS +     G TPL  
Sbjct: 447 VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLME 506

Query: 605 AAHYDNQKVALLLLDQGASPHAAAKNGY-TPLHIAAKKNQMDIATTLLEYGADANAVTRQ 663
           AA   ++++  LLL QGA+ +A  +    T L +A     +++A  L++ GAD       
Sbjct: 507 AAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCST 566

Query: 664 GIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHV 723
            +     AAQEGH+++V  LL   ANV+ +  +G T L  A +    +VA+VL+  GA +
Sbjct: 567 PLME---AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 623

Query: 724 DAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT-KNGYTPLHQAAQQGHTHIINVL 782
           + +++ G TPL      G++  V FL+   A VN  T  N +T L  A   GH  ++ +L
Sbjct: 624 EHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELL 683

Query: 783 LQNNASPNELTVNGNTALGIARRLGYISVV 812
           L + A P     +G+T L  A + G+ SVV
Sbjct: 684 LAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713



 Score =  215 bits (547), Expect = 9e-55
 Identities = 174/541 (32%), Positives = 263/541 (48%), Gaps = 38/541 (7%)

Query: 72  QNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGA 131
           Q+   +L  A  EG V  V +LL    +V+  T++G + L +A  AG  E+ +VL+   A
Sbjct: 232 QSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 291

Query: 132 NVNAQSQNG-FTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190
           NV  +   G  TPL  AA   H+++VK LL + A  +  +  G T L  A   G+  VV 
Sbjct: 292 NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVK 351

Query: 191 LLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINV 250
           +LLE+                      A++   N+N        G TPL  A   G++ V
Sbjct: 352 VLLES---------------------GASIEDHNEN--------GHTPLMEAGSAGHVEV 382

Query: 251 ATLLLNRAAAVDFTARNDI--TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG 308
           A LLL   A ++ T  N+   + L +A  +G+  MV+ LL+ GA  + KT +  T L   
Sbjct: 383 ARLLLENGAGIN-THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEA 441

Query: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL 368
              GH +V  +LLD  A +     +  SPL +A  G H+    LL++    +++V ++  
Sbjct: 442 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGY 501

Query: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGF-TPLHIACKKNRIKVMELLLKHGASIQ 427
           T L  AA  GH ++  +LL + AN NA+      T L +AC    ++V + L+K GA I+
Sbjct: 502 TPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE 561

Query: 428 AVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQ 487
                  TP+  AA  GH+ +V  L+  GA+ + T   G+TAL  A  +G  +V   L+Q
Sbjct: 562 LGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618

Query: 488 DGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG-YTPLHLSAREGHED 546
            GA +E +++  +TPL  +AR G    VQ L+ +GA+ N  T +  +T L L+   GH  
Sbjct: 619 AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLA 678

Query: 547 VAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAA 606
           V   LL HGA  +   K G T L  AAK G   V   LL    +  +A    +T L   +
Sbjct: 679 VVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPS 738

Query: 607 H 607
           H
Sbjct: 739 H 739



 Score =  195 bits (495), Expect = 9e-49
 Identities = 159/490 (32%), Positives = 241/490 (49%), Gaps = 21/490 (4%)

Query: 11  NRDL-EINAEEEPEKKRKHRKRSRDRKKKSDANASYL-RAARAGHLEKALDYIKNGVDIN 68
           NR L E  +E +    RK     R   + ++   S L  A  AG+ E A   +    ++ 
Sbjct: 235 NRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 294

Query: 69  ICNQNG-LNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLV 127
                G +  L  A+  GHV++V  LL  +A+V+A +  GNTAL  A   G  +VVKVL+
Sbjct: 295 DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL 354

Query: 128 TNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLAVALQQGHD 186
            +GA++   ++NG TPL  A    H+EV + LL+NGA   + + E   + L +A  +GH 
Sbjct: 355 ESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHL 414

Query: 187 QVVSLLLENDTKGKVRLPALHIAARK----DDTKAAALLLQNDNNADVESKSGFTPLHIA 242
           ++V  LLE     + +   +H A  +       + A LLL +    ++ + S  +PL +A
Sbjct: 415 EMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 474

Query: 243 AHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD-- 300
           A  G++ +A LL+ R A+++       TPL  A++ G+  MV LLL +GA I+A+T +  
Sbjct: 475 ACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQ 534

Query: 301 --GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS-PLHMATQGDHLNCVQLLLQHN 357
              LT   CG   G  +V + L+   A I    + G S PL  A Q  HL  V+ LL   
Sbjct: 535 ETALTLACCG---GFLEVADFLIKAGADI----ELGCSTPLMEAAQEGHLELVKYLLAAG 587

Query: 358 VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVME 417
             V   T    TAL  A   GH  VA VLL   A+   ++  G TPL  A +   +  ++
Sbjct: 588 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQ 647

Query: 418 LLLKHGASIQAVT-ESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARS 476
            L+  GA++   T  +  T + +A   GH+ +V  L+ HGA P      G T L  AA+ 
Sbjct: 648 FLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 707

Query: 477 GQAEVVRYLV 486
           G   VV YL+
Sbjct: 708 GHTSVVCYLL 717



 Score =  187 bits (476), Expect = 2e-46
 Identities = 144/471 (30%), Positives = 226/471 (47%), Gaps = 8/471 (1%)

Query: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKA-LNGFTPLHIACKKNRIKVMELLLKHGA 424
           + L  L  +  C   + A  L   +A   A A  +    L  AC +  +  +  LL  G 
Sbjct: 199 EVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGR 258

Query: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE-TALHMAARSGQAEVVR 483
           S+   TE G + + +A   G+  +   L+   A+     ++G+ T L  AA  G  ++V+
Sbjct: 259 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVK 318

Query: 484 YLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
            L+   A V A++    T L  +   G  D+V+ LL+ GAS      +G+TPL  +   G
Sbjct: 319 LLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAG 378

Query: 544 HEDVAAFLLDHGASLSITTKK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPL 602
           H +VA  LL++GA ++  + +   + L +A   G LE+   LL+  A  +       T L
Sbjct: 379 HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL 438

Query: 603 HVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTR 662
             A    + +VA LLLD GA  +  A +  +PL +AA    +++A  L+E GA    V  
Sbjct: 439 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVND 498

Query: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNL-SNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721
           +G   +  AA+EGH +MV+LLLG+ AN+N  + ++  T L LA     + VA+ L+  GA
Sbjct: 499 EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 558

Query: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781
            ++       TPL      G++++V +LL   A V+A T  G T L  A + GHT + +V
Sbjct: 559 DIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADV 615

Query: 782 LLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKH 832
           LLQ  A     +  G T L  A R G++  V  L I     +  TT    H
Sbjct: 616 LLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL-ISKGANVNRTTANNDH 665



 Score =  187 bits (476), Expect = 2e-46
 Identities = 219/842 (26%), Positives = 360/842 (42%), Gaps = 116/842 (13%)

Query: 46   LRAARAGHLEKALDYIKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAAT 104
            + A  AGH+E A   ++NG  IN   N+   +AL LA  +GH+E+V  LL+  A+ +  T
Sbjct: 372  MEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKT 431

Query: 105  KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
             + +TAL  A + G  EV ++L+ +GA VN  + +  +PL +AA   H+E+   L++ GA
Sbjct: 432  DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491

Query: 165  SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN 224
            S     ++G+TPL  A ++GH+++V+LLL             +I A+ ++T+  AL L  
Sbjct: 492  SLEEVNDEGYTPLMEAAREGHEEMVALLLGQ---------GANINAQTEETQETALTLAC 542

Query: 225  DNN----ADVESKSG-------FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLH 273
                   AD   K+G        TPL  AA  G++ +   LL   A V  T     T L 
Sbjct: 543  CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602

Query: 274  VASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT-K 332
             A + G+ ++  +LL  GA ++ ++  G TPL   AR+GH   V+ L+ + A +   T  
Sbjct: 603  YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662

Query: 333  NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
            N  + L +A  G HL  V+LLL H         D  T L  AA  GH  V   LLD   N
Sbjct: 663  NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722

Query: 393  ----PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448
                P         P H   +  R+ V  L +     +    E    P +VA  +     
Sbjct: 723  LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPM-----VVPPQEPDKPPANVATTL----- 772

Query: 449  VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ---VEAKAKDDQTPLHI 505
               + +  AS      + +++ H+ A S   +V  Y+     +    EA+ K  +    I
Sbjct: 773  --PIRNKAAS------KQKSSSHLPANS--QDVQGYITNQSPESIVEEAQGKLTELEQRI 822

Query: 506  SARLGKADIVQQLLQQGASPNAATTSGYTPLHLSARE---GHEDVAAFLLDHGASLSITT 562
               + K   +Q L  + A  +  T      L+ +  E     + +   L      L + T
Sbjct: 823  KEAIEKNAQLQSL--ELAHADQLTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKT 880

Query: 563  KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALL-----L 617
            ++      +  +Y +++   + LQ+           LTP+ V         A L     +
Sbjct: 881  QQ-----QLKKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPV 935

Query: 618  LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI------------ 665
            L +      AA+ G+ P+   A    + +A   L  G+ AN    QG+            
Sbjct: 936  LLKDEPQQTAAQMGFAPIQPLAMPQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQL 995

Query: 666  ----ASVHLAAQEGHV-------------DMVSLLLGRNANVNLSNKSGLTPLHLAA--- 705
                  +    Q+G +             D+++ + GR +   +SN    TP H  A   
Sbjct: 996  AGLGQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRAS--AMSN----TPTHSIAASI 1049

Query: 706  QEDRVNVAEVLVNQGA--------HVDAQTKMGY-TPLHVGCHYGNIKIVNFLLQHSAKV 756
             + +      +++  A         +DAQT+  + T L + C  G+ ++V  LL+  A +
Sbjct: 1050 SQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASI 1109

Query: 757  NAKTKNGYTPLHQAAQQGHTHIINVLLQNNA---SPNELTVNGNTALGIARRLGYISVVD 813
              + K G+TPL  AA  GH  ++ +LL N A   + +E T   +T L +A   G   VV+
Sbjct: 1110 EHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT--KDTPLSLACSGGRQEVVE 1167

Query: 814  TL 815
             L
Sbjct: 1168 LL 1169



 Score =  176 bits (447), Expect = 3e-43
 Identities = 121/324 (37%), Positives = 177/324 (54%), Gaps = 16/324 (4%)

Query: 77   ALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
            AL LA   GH E+V  LL+R A+++   KKG T L +A+ AG   VV++L+ NGA++ AQ
Sbjct: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145

Query: 137  SQ-NGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL-- 193
            S+    TPL +A      EVV+ LL  GA++       +TPL++A   G+  ++ +LL  
Sbjct: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205

Query: 194  ----ENDTKGKVRLPALHIAARKDDTKAAALLLQ--NDNNADVESKSGFTPLHIAAHYGN 247
                 + T  K+ +  L +AA    T A  LLL   +D NA +E+    T L +A   G 
Sbjct: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN-TALTLACFQGR 1264

Query: 248  INVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDA----KTRDGLT 303
              V +LLL+R A V+  A+  +TPL  A+  G A + ++LLD+GA ++A     +RD  T
Sbjct: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD--T 1322

Query: 304  PLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDV 363
             L   A  GH +  E+L+ R A I  + K G +PL +A  G HL+ VQLL+Q    VD  
Sbjct: 1323 ALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAA 1382

Query: 364  TNDYLTALHVAAHCGHYKVAKVLL 387
             N  +T L  A   GH KV + L+
Sbjct: 1383 DNRKITPLMAAFRKGHVKVVRYLV 1406



 Score =  176 bits (446), Expect = 5e-43
 Identities = 118/333 (35%), Positives = 179/333 (53%), Gaps = 7/333 (2%)

Query: 426  IQAVTESGL-TPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
            I A TES   T + +A   GH  +V  L+  GAS    + +G T L +AA +G   VV  
Sbjct: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEI 1134

Query: 485  LVQDGAQVEAKA-KDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
            L+ +GA +EA++ +   TPL ++   G+ ++V+ LL +GA+      S YTPL L+A  G
Sbjct: 1135 LLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194

Query: 544  HEDVAAFLLDHGASLSITT--KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGL-T 600
            + ++   LL+ GA ++  T  K G +PL +AA  G      LLL   +  +A  ++   T
Sbjct: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254

Query: 601  PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA- 659
             L +A      +V  LLLD+ A+    AK G TPL  AA     ++   LL+ GAD NA 
Sbjct: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314

Query: 660  -VTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVN 718
             V      ++ +AA +GH     LL+GR A++++ NK G TPL LAA    ++V ++LV 
Sbjct: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374

Query: 719  QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ 751
             GA VDA      TPL      G++K+V +L++
Sbjct: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score =  173 bits (439), Expect = 3e-42
 Identities = 121/364 (33%), Positives = 188/364 (51%), Gaps = 40/364 (10%)

Query: 99   NVDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVK 157
            ++DA T+  + TAL +A   G  E+V+ L+  GA++  + + GFTPL +AA   H+ VV+
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133

Query: 158  FLLDNGA---SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDD 214
             LLDNGA   +QS  T+D  TPL++A   G  +VV LLL                     
Sbjct: 1134 ILLDNGADIEAQSERTKD--TPLSLACSGGRQEVVELLLARGA----------------- 1174

Query: 215  TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT--ARNDITPL 272
                        N +  + S +TPL +AA  G +N+  +LLN  A ++    ++  I+PL
Sbjct: 1175 ------------NKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPL 1222

Query: 273  HVASKRGNANMVKLLLDRGAKIDAKTRDGL-TPLHCGARSGHEQVVEMLLDRAAPILSKT 331
             +A+  G+   VKLLLD G+ I+A+      T L      G  +VV +LLDR A +  + 
Sbjct: 1223 MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1282

Query: 332  KNGLSPLHMATQGDHLNCVQLLLQHNVPVD--DVTNDYLTALHVAAHCGHYKVAKVLLDK 389
            K GL+PL  A  G +    ++LL     V+   V +   TAL +AA  GHYK  ++L+ +
Sbjct: 1283 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1342

Query: 390  KANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449
             A+ + +   G TPL +A     + V++LL++ GA + A     +TP+  A   GHV +V
Sbjct: 1343 GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVV 1402

Query: 450  SQLM 453
              L+
Sbjct: 1403 RYLV 1406



 Score =  165 bits (417), Expect = 1e-39
 Identities = 116/328 (35%), Positives = 175/328 (53%), Gaps = 8/328 (2%)

Query: 399  NGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS 458
            N  T L +AC     ++++ LL+ GASI+   + G TP+ +AA  GHV +V  L+ +GA 
Sbjct: 1082 NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 1141

Query: 459  PNTTNVR-GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517
                + R  +T L +A   G+ EVV  L+  GA  E +   D TPL ++A  G  +I++ 
Sbjct: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1201

Query: 518  LLQQGASPNAATTS--GYTPLHLSAREGHEDVAAFLLDHGASLS--ITTKKGFTPLHVAA 573
            LL  GA  N+ T S  G +PL L+A  GH      LLD G+ ++  I T +  T L +A 
Sbjct: 1202 LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN-TALTLAC 1260

Query: 574  KYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA--AAKNG 631
              G+ EV +LLL + A+ +   K+GLTPL  AA     +V  +LLD+GA  +A     + 
Sbjct: 1261 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320

Query: 632  YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691
             T L IAA K        L+  GA  +   ++G   + LAA  GH+D+V LL+   A+V+
Sbjct: 1321 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1380

Query: 692  LSNKSGLTPLHLAAQEDRVNVAEVLVNQ 719
             ++   +TPL  A ++  V V   LV +
Sbjct: 1381 AADNRKITPLMAAFRKGHVKVVRYLVKE 1408



 Score =  163 bits (412), Expect = 4e-39
 Identities = 126/366 (34%), Positives = 184/366 (50%), Gaps = 40/366 (10%)

Query: 132  NVNAQSQ-NGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190
            +++AQ++ N  T L +A    H E+V+ LL+ GAS     + GFTPL +A   GH  VV 
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133

Query: 191  LLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFT---PLHIAAHYGN 247
            +LL                               DN AD+E++S  T   PL +A   G 
Sbjct: 1134 ILL-------------------------------DNGADIEAQSERTKDTPLSLACSGGR 1162

Query: 248  INVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD--GLTPL 305
              V  LLL R A  +    +D TPL +A+  G  N++K+LL+ GA+I+++T    G++PL
Sbjct: 1163 QEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPL 1222

Query: 306  HCGARSGHEQVVEMLLDRAAPILSKTK-NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT 364
               A +GH   V++LLD  + I ++ + N  + L +A        V LLL     V+   
Sbjct: 1223 MLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA 1282

Query: 365  NDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGF--TPLHIACKKNRIKVMELLLKH 422
               LT L  AA  G+ +V +VLLDK A+ NA  +     T L IA  K   K  ELL+  
Sbjct: 1283 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1342

Query: 423  GASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVV 482
            GA I    + G TP+ +AA  GH+++V  L+  GA  +  + R  T L  A R G  +VV
Sbjct: 1343 GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVV 1402

Query: 483  RYLVQD 488
            RYLV++
Sbjct: 1403 RYLVKE 1408



 Score =  158 bits (399), Expect = 1e-37
 Identities = 132/431 (30%), Positives = 205/431 (47%), Gaps = 18/431 (4%)

Query: 439  VAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKD 498
            +AA  G  + +S    H  + + +  +  T   + + S    +   +  D AQ E+   +
Sbjct: 1027 MAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDID-AQTES---N 1082

Query: 499  DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 558
              T L ++   G  ++VQ LL++GAS       G+TPL L+A  GH  V   LLD+GA +
Sbjct: 1083 HDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADI 1142

Query: 559  SITTKKGF-TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
               +++   TPL +A   G+ EV  LLL + A+ +    S  TPL +AA      +  +L
Sbjct: 1143 EAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1202

Query: 618  LDQGA--SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA-VTRQGIASVHLAAQE 674
            L+ GA  +    +K G +PL +AA          LL+ G+D NA +      ++ LA  +
Sbjct: 1203 LNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQ 1262

Query: 675  GHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY--T 732
            G  ++VSLLL R ANV    K+GLTPL  AA      V  VL+++GA V+A        T
Sbjct: 1263 GRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1322

Query: 733  PLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 792
             L +    G+ K    L+   A ++ + K G TPL  AA  GH  ++ +L+Q  A  +  
Sbjct: 1323 ALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAA 1382

Query: 793  TVNGNTALGIARRLGYISVVDTL-KIVTE-----ETMT-TTTVTEKHKMNVPE-TMNEVL 844
                 T L  A R G++ VV  L K V +     E M    T+T+K  +      M  ++
Sbjct: 1383 DNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIV 1442

Query: 845  DMSDDEVRKAN 855
               D +  +AN
Sbjct: 1443 QAKDRQAAEAN 1453



 Score =  158 bits (399), Expect = 1e-37
 Identities = 110/323 (34%), Positives = 165/323 (51%), Gaps = 6/323 (1%)

Query: 205  ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
            AL +A      +    LL+   + +   K GFTPL +AA  G++ V  +LL+  A ++  
Sbjct: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145

Query: 265  A-RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDR 323
            + R   TPL +A   G   +V+LLL RGA  + +     TPL   A  G+  ++++LL+ 
Sbjct: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205

Query: 324  AAPILSKT--KNGLSPLHMATQGDHLNCVQLLLQHNVPVD-DVTNDYLTALHVAAHCGHY 380
             A I S+T  K G+SPL +A    H   V+LLL     ++  +  +  TAL +A   G  
Sbjct: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1265

Query: 381  KVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA--VTESGLTPIH 438
            +V  +LLD+KAN   +A  G TPL  A      +V  +LL  GA + A  V  S  T + 
Sbjct: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1325

Query: 439  VAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKD 498
            +AA  GH      L+  GA  +  N +G T L +AA  G  +VV+ LVQ GA V+A    
Sbjct: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1385

Query: 499  DQTPLHISARLGKADIVQQLLQQ 521
              TPL  + R G   +V+ L+++
Sbjct: 1386 KITPLMAAFRKGHVKVVRYLVKE 1408



 Score =  134 bits (338), Expect = 2e-30
 Identities = 98/331 (29%), Positives = 159/331 (48%), Gaps = 43/331 (12%)

Query: 34   DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93
            D + +S+ + +   A   GH E     ++ G  I   ++ G   L LA+  GHV VV  L
Sbjct: 1076 DAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEIL 1135

Query: 94   LQREANVDAATKKG-NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENH 152
            L   A+++A +++  +T L +A   G+ EVV++L+  GAN   ++ + +TPL +AA   +
Sbjct: 1136 LDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGY 1195

Query: 153  LEVVKFLLDNGASQSLATED--GFTPLAVALQQGHDQVVSLLLE--NDTKGKV---RLPA 205
            + ++K LL+ GA  +  T    G +PL +A   GH   V LLL+  +D   ++   R  A
Sbjct: 1196 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTA 1255

Query: 206  LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH------------------------- 240
            L +A  +  T+  +LLL    N +  +K+G TPL                          
Sbjct: 1256 LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 1315

Query: 241  ----------IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDR 290
                      IAA  G+     LL+ R A +D   +   TPL +A+  G+ ++V+LL+  
Sbjct: 1316 VPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA 1375

Query: 291  GAKIDAKTRDGLTPLHCGARSGHEQVVEMLL 321
            GA +DA     +TPL    R GH +VV  L+
Sbjct: 1376 GADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406



 Score = 81.6 bits (200), Expect = 2e-14
 Identities = 63/183 (34%), Positives = 85/183 (46%), Gaps = 36/183 (19%)

Query: 48   AARAGHLEKALDYIKNGVDINICNQNGLN-ALHLASKEGHVEVVSELLQREANVDAATKK 106
            AA  GH       +  G DIN   +   N AL LA  +G  EVVS LL R+ANV+   K 
Sbjct: 1225 AAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKT 1284

Query: 107  GNTALHIASLAGQAEVVKVLVTNGANVNA------------------------------- 135
            G T L  A+  G AEV +VL+  GA+VNA                               
Sbjct: 1285 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1344

Query: 136  ----QSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSL 191
                +++ G TPL++AA   HL+VV+ L+  GA    A     TPL  A ++GH +VV  
Sbjct: 1345 HIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRY 1404

Query: 192  LLE 194
            L++
Sbjct: 1405 LVK 1407



 Score = 40.8 bits (94), Expect = 0.030
 Identities = 110/508 (21%), Positives = 193/508 (37%), Gaps = 76/508 (14%)

Query: 1468 RYSYLTEPGMIERSTGATRSLPTTYSYKPFFSTRPYQSWTTAP----------ITVPGPA 1517
            R+S     G    S G+  S PTT +     ST P  S   +P          +TV   +
Sbjct: 1948 RHSNQNSSGSQVNSAGSLTSSPTTTTSSSA-STVPGTSTNGSPSSPSVRRQLFVTVVKTS 2006

Query: 1518 KSGFTSLSSSSSNT-----------PSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISD 1566
             +  T++++++SN            P+A     + S S+PSP     G S  S +   S 
Sbjct: 2007 NATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSA 2066

Query: 1567 VASPIRSFRTM---SSPIKTVVSQSPYNIQVSSGTLA------RAPAVTEATPLKGLASN 1617
              + + S       S P+    +  P N   SSG+ +      + P      P   L  +
Sbjct: 2067 SPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQS 2126

Query: 1618 ST-----------FSSRTSPVTTAGSLLERSSITMTPPASPKSNINMYSSSLPFKSIITS 1666
                          ++ ++PV    +      +  TP   P+    M + ++      T+
Sbjct: 2127 QVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTT 2186

Query: 1667 AAPLISSPLKSVVSPVKSAVDVISSAKITMASSLSSPVKQMPGHAEVALVNGSISPLKYP 1726
            A      P K+  S   S+V V+S   I    S+ S V+     +  +    S+ P   P
Sbjct: 2187 A------PHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTLSTQSACQNSVHPANKP 2240

Query: 1727 ----SSSTLINGCKATATLQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFS-PL-RS 1780
                 S+ L  G  +T       S+      SVVS+ +     +   ++ +P S PL +S
Sbjct: 2241 IAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQS 2300

Query: 1781 YVSAAPSAFQSLRTPSAS-ALYTSLGSSISATTSSVT------SSIITVPVYSVVNVLPE 1833
              S AP     L+ P+ S +   ++ S   + T S T      S+I    +Y      P 
Sbjct: 2301 DTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYG-----PG 2355

Query: 1834 PALKKLPDSNSFTK---SAAALLSPIKTLTTETHPQPHFSRTSSPVKSSLFLAPSALKLS 1890
              L   P + +F +   S  +LL+P  + + ++  Q   S   +P       APS++ L 
Sbjct: 2356 APLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSP-----APSSVPLG 2410

Query: 1891 T--PSSLSSSQEILKDVAEMKEDLMRMT 1916
            +  PS++S  +++   +   +   +R T
Sbjct: 2411 SEKPSNVSQDRKVPVPIGTERSARIRQT 2438



 Score = 36.2 bits (82), Expect = 0.74
 Identities = 49/229 (21%), Positives = 75/229 (32%), Gaps = 36/229 (15%)

Query: 3866 PIKAT-SPKDTFPPNHMS-NTKASKMKQVSQSEKTKALTTSSCVDVKSRIPVKNTHRDNI 3923
            P +AT SPK    P H + N+  S++        +   TTSS     S +P         
Sbjct: 1934 PARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSA---STVP--------- 1981

Query: 3924 IAVRKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVTTTTTTATTTTTTTTTTTTSCTVK 3983
                    T   G P     +          R   VT   T+  TTTT TTT + + T  
Sbjct: 1982 -------GTSTNGSPSSPSVR----------RQLFVTVVKTSNATTTTVTTTASNNNTAP 2024

Query: 3984 VRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSLSETSR 4043
               +      K         S         +S       S L     S ++  S SE   
Sbjct: 2025 TNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSR-----NSPLDCGSASPNKVASSSEQEA 2079

Query: 4044 GGQPSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDI 4092
            G  P V T + R   + ++   S +     +   S    P+ P +++ +
Sbjct: 2080 GSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQV 2128



 Score = 33.1 bits (74), Expect = 6.2
 Identities = 85/416 (20%), Positives = 149/416 (35%), Gaps = 53/416 (12%)

Query: 1519 SGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSSVK-------SISDVASPI 1571
            SG  S+  S + +   S   S  + S PSP+ S  G  T +S K          +V    
Sbjct: 1668 SGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRS 1727

Query: 1572 RSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAVTEATPLKGLASNSTFSSRTSPVTTAG 1631
            +     S+ I  V+ +   NI           A  +    K    +   + R    +T  
Sbjct: 1728 KKVSVPSTVISRVIGRGGCNINAIREFTG---AHIDIDKQKDKTGDRIITIRGGTESTRQ 1784

Query: 1632 SLLERSSITMTPPAS-----PKSNINMYSSSLPFKSIITSAAPLISSPLKSVVSPVKSAV 1686
            +    +++   P        PK+ +   S++    S I S+AP  ++   S++    + V
Sbjct: 1785 ATQLINALIKDPDKEIDELIPKNRLKSSSAN----SKIGSSAPTTTAANTSLMGIKMTTV 1840

Query: 1687 DVISSAKITMA------------SSLSSPVKQMPGHAEVALVNGSISPLKYPSSSTLING 1734
             + S+++   A             ++ +PV  +     V+L      PL YP      + 
Sbjct: 1841 ALSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPVSL------PLAYPPPQ-FAHA 1893

Query: 1735 CKATATLQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFSPLRSYVSAAPSAF-QSLR 1793
              A  T Q+          +         +  +      P SP R+  S  P    +   
Sbjct: 1894 LLAAQTFQQ--IRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSN 1951

Query: 1794 TPSASALYTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPALKK------LPDSNSFTK 1847
              S+ +   S GS  S+ T++ +SS  TVP  S       P++++      +  SN+ T 
Sbjct: 1952 QNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTT 2011

Query: 1848 SAAALLSPIKTL-TTETHPQP----HFSRTSSPVKSSLFLAPSALKLSTPSSLSSS 1898
            +     S   T  T  T+P P    H+   SSP   S    P  +  ++P    S+
Sbjct: 2012 TVTTTASNNNTAPTNATYPMPTAKEHYP-VSSPSSPSPPAQPGGVSRNSPLDCGSA 2066


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  222 bits (565), Expect = 7e-57
 Identities = 163/522 (31%), Positives = 251/522 (48%), Gaps = 44/522 (8%)

Query: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327
           D   L  A   G+ N V+ LLD G  ++  T +G + L     +G+ ++ ++LL   A +
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264

Query: 328 LSKTKNG-LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
             +   G ++PL  A+ G +L+ V+LLL H+  V+  +    TAL  A   G   + KVL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324

Query: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT----ESGLTPIHVAAF 442
           L++ AN      NG TPL  A     ++V  +LL HGA I   +    ES LT   +A +
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACY 381

Query: 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502
            GH+++V  L+  GA          TAL  A   G  EV R L+  GAQV   A   ++P
Sbjct: 382 KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 441

Query: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562
           L ++A  G  ++   L+++GA+       GYTPL  +AREGHE++ A LL  GA+++  T
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501

Query: 563 KK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621
           ++   T L +A   G  EVA+ L++  A  +       TPL  A+   + ++   LL  G
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 558

Query: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVS 681
           A+ HA    G T L  A +    D+A  LL+ GAD    +  G   +  AA+ GH+  V 
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 618

Query: 682 LLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYG 741
            L+ + ANVN                                 A     +T + + C  G
Sbjct: 619 FLISKGANVN--------------------------------RATANNDHTVVSLACAGG 646

Query: 742 NIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 783
           ++ +V  LL H A    + K+G T L +AA+ GHT++++ LL
Sbjct: 647 HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688



 Score =  220 bits (561), Expect = 2e-56
 Identities = 173/571 (30%), Positives = 280/571 (49%), Gaps = 32/571 (5%)

Query: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGD-----------HLNCVQLLLQHNVPVDDVTN 365
           V   LD AA  L++ K   S  H A Q D            +N V+ LL     V++ T 
Sbjct: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236

Query: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG-FTPLHIACKKNRIKVMELLLKHGA 424
           +  + L +A   G+Y++A+VLL   AN   +   G  TPL  A     + +++LLL H A
Sbjct: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296

Query: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
            + + + +G T +  A   G V+IV  L++ GA+    N  G T L  AA +G  EV R 
Sbjct: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356

Query: 485 LVQDGAQVEAKAKD-DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
           L+  GA +   + +  ++ L ++   G  D+V+ LL+ GA     T   +T L  +  +G
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416

Query: 544 HEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLH 603
           H +VA  LLD GA +++      +PL +AA  G +E+A LL+++ A+ +     G TPL 
Sbjct: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476

Query: 604 VAAHYDNQKVALLLLDQGASPHAAAKNGY-TPLHIAAKKNQMDIATTLLEYGADANAVTR 662
            AA   ++++  LLL QGA+ +A  +    T L +A      ++A  L++ GAD      
Sbjct: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536

Query: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAH 722
             +     A+QEGH+++V  LL   ANV+ +  +G T L  A +    +VA+VL+  GA 
Sbjct: 537 TPLME---ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593

Query: 723 VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN-AKTKNGYTPLHQAAQQGHTHIINV 781
           ++ +++ G TPL      G++  V FL+   A VN A   N +T +  A   GH  ++ +
Sbjct: 594 LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 653

Query: 782 LLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMT--TTTVTE-----KHKM 834
           LL + A P     +G+T L  A + G+ +VV  L       ++  TT V++     + + 
Sbjct: 654 LLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713

Query: 835 NVPETMNEVLDM-----SDDEVRKANAPEML 860
            VP      L M       D   + N+P +L
Sbjct: 714 QVPRVPTHTLAMVVPPQEPDRTSQENSPALL 744



 Score =  197 bits (501), Expect = 2e-49
 Identities = 157/498 (31%), Positives = 245/498 (49%), Gaps = 20/498 (4%)

Query: 2   AHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYL-RAARAGHLEKALDY 60
           +H A Q+      E  ++ +    RK     R   + ++   S L  A  AG+ E A   
Sbjct: 198 SHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVL 257

Query: 61  IKNGVDI-NICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ 119
           +    ++ +  N+  +  L  AS  G++++V  LL  +A+V++ +  GNTAL  A   G 
Sbjct: 258 LAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317

Query: 120 AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLA 178
            ++VKVL+  GAN+   ++NG TPL  AA   H+EV + LLD+GA   + + E   + L 
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377

Query: 179 VALQQGHDQVVSLLLENDTKGKVRLPALHIAARK----DDTKAAALLLQNDNNADVESKS 234
           +A  +GH  +V  LLE     + +   +H A  +       + A LLL +    ++ + S
Sbjct: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437

Query: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294
             +PL +AA  G++ +A LL+ R A ++       TPL  A++ G+  MV LLL +GA I
Sbjct: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497

Query: 295 DAKTRD----GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS-PLHMATQGDHLNC 349
           +A+T +     LT   CG   G  +V + L+   A I    + G S PL  A+Q  HL  
Sbjct: 498 NAQTEETQETALTLACCG---GFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLEL 550

Query: 350 VQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACK 409
           V+ LL     V   T    TAL  A   GH  VA VLL   A+   ++  G TPL  A +
Sbjct: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 610

Query: 410 KNRIKVMELLLKHGASI-QAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468
              +  ++ L+  GA++ +A   +  T + +A   GH+ +V  L+ HGA P      G T
Sbjct: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670

Query: 469 ALHMAARSGQAEVVRYLV 486
            L  AA+ G   VV YL+
Sbjct: 671 MLIEAAKGGHTNVVSYLL 688



 Score =  171 bits (434), Expect = 1e-41
 Identities = 197/816 (24%), Positives = 347/816 (42%), Gaps = 97/816 (11%)

Query: 46   LRAARAGHLEKALDYIKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAAT 104
            + AA AGH+E A   + +G  IN   N+   +AL LA  +GH+++V  LL+  A+ +  T
Sbjct: 343  MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKT 402

Query: 105  KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
             + +TAL  A + G  EV ++L+ +GA VN  + +  +PL +AA   H+E+   L++ GA
Sbjct: 403  DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 462

Query: 165  SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN 224
            +     ++G+TPL  A ++GH+++V+LLL             +I A+ ++T+  AL L  
Sbjct: 463  NLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQETALTL-- 511

Query: 225  DNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMV 284
                             A   G   VA  L+   A ++       TPL  AS+ G+  +V
Sbjct: 512  -----------------ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELV 551

Query: 285  KLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQG 344
            K LL  GA + A T  G T L     +GH  V ++LL   A +  +++ G +PL  A + 
Sbjct: 552  KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARA 611

Query: 345  DHLNCVQLLLQHNVPVDDVT-NDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTP 403
             HL  VQ L+     V+  T N+  T + +A   GH  V ++LL   A+P  +  +G T 
Sbjct: 612  GHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTM 671

Query: 404  LHIACKKNRIKVMELLLKHGASIQAVTESGLT---------------PIHVAAFMGHVNI 448
            L  A K     V+  LL +  ++ +V  + ++               P H  A +    +
Sbjct: 672  LIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMV----V 727

Query: 449  VSQLMHHGASPNT---------TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
              Q     +  N+         T+ +  ++L +A +        Y   +    E + K +
Sbjct: 728  PPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVEETEGKLN 787

Query: 500  QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559
            +    ISA + KA +    L QG   N               +  + +   L      L 
Sbjct: 788  ELGQRISA-IEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQKVERQLQ 846

Query: 560  ITTKKGFTPLHVAAKYGKLEVANLLLQ---KSASPDAAGKSGLTPLHVAAHYDNQKVALL 616
            + T++ FT  ++  K G+ +  +L  Q   +   P+  G   L   H +   +  +V  +
Sbjct: 847  MKTQQQFTKEYLETK-GQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFS---ELPQVDTI 902

Query: 617  LL------DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 670
            L       D+  SP +A +  + P+          +++    + +D  +    G  S+ L
Sbjct: 903  LFKDNDVDDEQQSPPSAEQIDFVPV--------QPLSSPQCNFSSDLGS---NGTNSLEL 951

Query: 671  AAQEGHVDMVS----LLLGRNANVNLSNKSGL---TPLHLAAQ--EDRVNVAEVLVNQGA 721
                G+  +V      + G +  + +    GL   TP        +D +      V  G+
Sbjct: 952  QKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGS 1011

Query: 722  HVDAQTKMGYTPLHVGCHYGNIKIVNF-LLQHSAKVNAKTKNGY-TPLHQAAQQGHTHII 779
            +  +QT    TP        N+   +   +  S  ++A T++ + T L  A   GH  ++
Sbjct: 1012 NSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELV 1071

Query: 780  NVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
            +VL+  +A        G T L +A   G++ VV+ L
Sbjct: 1072 SVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107



 Score =  166 bits (421), Expect = 4e-40
 Identities = 137/467 (29%), Positives = 209/467 (44%), Gaps = 48/467 (10%)

Query: 73   NGLNALHLASKEGHVEVVSE------------LLQREANVDAATKKGNTALHIASLAGQA 120
            NG N+L L    G+ ++V +            L+Q    +  AT        +  L    
Sbjct: 944  NGTNSLELQKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIA-- 1001

Query: 121  EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180
              V   V  G+N ++Q+    TP          E       N ASQS+        +   
Sbjct: 1002 -AVSTRVPTGSNSSSQTTECLTP----------ESCSQTTSNVASQSMPPVYPSVDIDAH 1050

Query: 181  LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH 240
             +  HD                  AL +A      +  ++L+  D   +   K GFTPL 
Sbjct: 1051 TESNHDT-----------------ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLI 1093

Query: 241  IAAHYGNINVATLLLNRAAAVDFTA-RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTR 299
            +AA  G++ V  +LL++   ++  + R   TPL +A   G   +V LLL RGA  + +  
Sbjct: 1094 LAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNV 1153

Query: 300  DGLTPLHCGARSGHEQVVEMLLDRAAPILSKT--KNGLSPLHMATQGDHLNCVQLLLQHN 357
               TPL   A  G+  ++++LL+  A I S+T  K G+SPL +A    H+  V+LLL   
Sbjct: 1154 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213

Query: 358  VPVD-DVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVM 416
              ++  +  +  TAL +A   G  +V  +LLD+KAN   +A  G TPL  A      +V 
Sbjct: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1273

Query: 417  ELLLKHGASIQA--VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAA 474
             +LL  GA + A  V  S  T + +AA  GH      L+H GA  +  N +G T L +A+
Sbjct: 1274 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333

Query: 475  RSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521
              G  +VV+ LVQ GA V+A      TPL  + R G   +VQ L+++
Sbjct: 1334 NGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score =  157 bits (397), Expect = 2e-37
 Identities = 126/408 (30%), Positives = 196/408 (48%), Gaps = 48/408 (11%)

Query: 34   DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93
            D   +S+ + +   A   GH E     I     I   ++ G   L LA+  GHV VV  L
Sbjct: 1048 DAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107

Query: 94   LQREANVDAATKK-GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENH 152
            L +  +++A +++  +T L +A   G+ EVV +L+  GAN   ++ + +TPL +AA   +
Sbjct: 1108 LDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGY 1167

Query: 153  LEVVKFLLDNGASQSLATED--GFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAA 210
            + ++K LL+ GA  +  T    G +PL +A   GH   V LLL+                
Sbjct: 1168 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD---------------- 1211

Query: 211  RKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDIT 270
                       + +D NA +E+    T L +A   G   V +LLL+R A V+  A+  +T
Sbjct: 1212 -----------MGSDINAQIETNRN-TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLT 1259

Query: 271  PLHVASKRGNANMVKLLLDRGAKIDA----KTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326
            PL  A+  G A + ++LLD+GA ++A     +RD  T L   A  GH +  E+L+ R A 
Sbjct: 1260 PLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAH 1317

Query: 327  ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
            I  + K G +PL +A+ G H + VQLL+Q    VD   N  +T L  A   GH KV + L
Sbjct: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL 1377

Query: 387  LDKKANPNAKALNGFTPLHIACKK--NRIKVMELLLKHGASIQAVTES 432
            +        K +N F P  I C +    I   ELL K    ++ + ++
Sbjct: 1378 V--------KEVNQF-PSDIECMRYIATITDKELLKKCHQCVETIVKA 1416



 Score =  147 bits (371), Expect = 2e-34
 Identities = 101/338 (29%), Positives = 173/338 (51%), Gaps = 7/338 (2%)

Query: 462  TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521
            T    +TAL +A   G  E+V  L+   A++E + K   TPL ++A  G   +V+ LL +
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110

Query: 522  GASPNAATT-SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEV 580
            G    A +  +  TPL L+   G ++V   LL  GA+        +TPL +AA  G + +
Sbjct: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170

Query: 581  ANLLLQKSASPDA--AGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAK-NGYTPLHI 637
              +LL   A  ++    K G++PL +AA   +     LLLD G+  +A  + N  T L +
Sbjct: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230

Query: 638  AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSN--K 695
            A  + + ++ + LL+  A+     + G+  +  AA  G+ ++  +LL + A+VN      
Sbjct: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290

Query: 696  SGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK 755
            S  T L +AA +      E+L+++GAH+D + K G TPL +  + G+  +V  L+Q  A 
Sbjct: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350

Query: 756  VNAKTKNGYTPLHQAAQQGHTHIINVLLQN-NASPNEL 792
            V+A      TPL  A ++GH  ++  L++  N  P+++
Sbjct: 1351 VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDI 1388



 Score =  145 bits (366), Expect = 9e-34
 Identities = 114/369 (30%), Positives = 178/369 (48%), Gaps = 14/369 (3%)

Query: 501  TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560
            T L ++   G  ++V  L+ + A        G+TPL L+A  GH  V   LLD G  +  
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 561  TTKKGF-TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619
             +++   TPL +A   G+ EV +LLL + A+ +    S  TPL +AA      +  +LL+
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176

Query: 620  QGA--SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA-VTRQGIASVHLAAQEGH 676
             GA  +    +K G +PL +AA    +     LL+ G+D NA +      ++ LA  +G 
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236

Query: 677  VDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY--TPL 734
             ++VSLLL R ANV    K+GLTPL  AA      V  VL+++GA V+A        T L
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296

Query: 735  HVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTV 794
             +    G+ K    L+   A ++ + K G TPL  A+  GH  ++ +L+Q  A  +    
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356

Query: 795  NGNTALGIARRLGYISVVDTL-KIVTE-----ETMT-TTTVTEKHKM-NVPETMNEVLDM 846
               T L  A R G++ VV  L K V +     E M    T+T+K  +    + +  ++  
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKA 1416

Query: 847  SDDEVRKAN 855
             D +  +AN
Sbjct: 1417 KDQQAAEAN 1425



 Score =  134 bits (337), Expect = 2e-30
 Identities = 105/317 (33%), Positives = 160/317 (50%), Gaps = 10/317 (3%)

Query: 34  DRKKKSDA-NASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSE 92
           D++ K+D  + + + A   GH+E A   + +G  +N+   +  + L LA+  GHVE+ + 
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456

Query: 93  LLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGF-TPLYMAAQEN 151
           L++R AN++    +G T L  A+  G  E+V +L+  GAN+NAQ++    T L +A    
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516

Query: 152 HLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLP----ALH 207
             EV  FL+  GA   L      TPL  A Q+GH ++V  LL +             AL 
Sbjct: 517 FSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573

Query: 208 IAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVD-FTAR 266
            A     T  A +LLQ   + + ES+ G TPL  AA  G++     L+++ A V+  TA 
Sbjct: 574 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATAN 633

Query: 267 NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326
           ND T + +A   G+  +V+LLL  GA    + +DG T L   A+ GH  VV  LLD    
Sbjct: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693

Query: 327 ILSKTKNGLSPLHMATQ 343
           +LS     +S L   +Q
Sbjct: 694 VLSVPTTDVSQLPPPSQ 710



 Score = 87.4 bits (215), Expect = 3e-16
 Identities = 65/203 (32%), Positives = 99/203 (48%), Gaps = 15/203 (7%)

Query: 670  LAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729
            LA   GH ++VS+L+ R+A +   +K G TPL LAA    V V E+L+++G  ++AQ++ 
Sbjct: 1061 LACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSER 1120

Query: 730  GY-TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788
               TPL + C  G  ++V+ LL   A    +  + YTPL  AA  G+ +II +LL   A 
Sbjct: 1121 TKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 1180

Query: 789  PNELTVN--GNTALGIARRLGYISVVDTLKIVTE------ETMTTTTVTEKHKMNVPETM 840
             N  T +  G + L +A   G++  V  L  +        ET   T +T        E +
Sbjct: 1181 INSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVV 1240

Query: 841  NEVLDMSDDEVRKANAPEMLSDG 863
            + +LD      RKAN       G
Sbjct: 1241 SLLLD------RKANVEHRAKTG 1257



 Score = 35.4 bits (80), Expect = 1.3
 Identities = 47/181 (25%), Positives = 79/181 (43%), Gaps = 16/181 (8%)

Query: 1508 TAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISDV 1567
            + PITV     +    L  +++ TPS+   +    V   SP  +T+ +S TS+  S+  V
Sbjct: 1932 SCPITVSSVVAAS-QQLCVTNTRTPSSVRKQLFACVPKTSP-PATVISSVTSTCSSLPSV 1989

Query: 1568 AS-PIRSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAV----TEATPLKGLA--SNSTF 1620
            +S PI S +  ++ +    SQ+  + Q      A  P      T+  P+  L   S++  
Sbjct: 1990 SSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMANLCTPSSTAN 2049

Query: 1621 SSRTSPVTTAGSLLERSSITMTPPAS-------PKSNINMYSSSLPFKSIITSAAPLISS 1673
            S  +S   T G+     S + TP +S       P S  ++   S+PF S    A   ++S
Sbjct: 2050 SCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNSEPAPLTLTS 2109

Query: 1674 P 1674
            P
Sbjct: 2110 P 2110



 Score = 35.4 bits (80), Expect = 1.3
 Identities = 36/140 (25%), Positives = 60/140 (42%), Gaps = 13/140 (9%)

Query: 1523 SLSSSSSNTPSASPLKSIWSVSTPSPIKS-TLGASTTSSVKSISDVASPIRSFRTMSSPI 1581
            S SSS+SNTP A         S+P+P  S T   +  SSV  +S ++ P   F + S P 
Sbjct: 2050 SCSSSASNTPGAPETHPS---SSPTPTSSNTQEEAQPSSVSDLSPMSMP---FASNSEPA 2103

Query: 1582 KTVVSQSPYNIQVSSGTLARAPAVTEATPLKG--LASNSTFSSRTSPVTT---AGSLLER 1636
               ++ SP  +   +   +  P +    P     +    +F S     T      S+   
Sbjct: 2104 PLTLT-SPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIFVT 2162

Query: 1637 SSITMTPPASPKSNINMYSS 1656
            + +T+TPP  P + + + S+
Sbjct: 2163 NPVTLTPPQGPPAAVQLSSA 2182


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  222 bits (565), Expect = 7e-57
 Identities = 163/522 (31%), Positives = 251/522 (48%), Gaps = 44/522 (8%)

Query: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327
           D   L  A   G+ N V+ LLD G  ++  T +G + L     +G+ ++ ++LL   A +
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264

Query: 328 LSKTKNG-LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
             +   G ++PL  A+ G +L+ V+LLL H+  V+  +    TAL  A   G   + KVL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324

Query: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT----ESGLTPIHVAAF 442
           L++ AN      NG TPL  A     ++V  +LL HGA I   +    ES LT   +A +
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACY 381

Query: 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502
            GH+++V  L+  GA          TAL  A   G  EV R L+  GAQV   A   ++P
Sbjct: 382 KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 441

Query: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562
           L ++A  G  ++   L+++GA+       GYTPL  +AREGHE++ A LL  GA+++  T
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501

Query: 563 KK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621
           ++   T L +A   G  EVA+ L++  A  +       TPL  A+   + ++   LL  G
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 558

Query: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVS 681
           A+ HA    G T L  A +    D+A  LL+ GAD    +  G   +  AA+ GH+  V 
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 618

Query: 682 LLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYG 741
            L+ + ANVN                                 A     +T + + C  G
Sbjct: 619 FLISKGANVN--------------------------------RATANNDHTVVSLACAGG 646

Query: 742 NIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 783
           ++ +V  LL H A    + K+G T L +AA+ GHT++++ LL
Sbjct: 647 HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688



 Score =  220 bits (561), Expect = 2e-56
 Identities = 173/571 (30%), Positives = 280/571 (49%), Gaps = 32/571 (5%)

Query: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGD-----------HLNCVQLLLQHNVPVDDVTN 365
           V   LD AA  L++ K   S  H A Q D            +N V+ LL     V++ T 
Sbjct: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236

Query: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG-FTPLHIACKKNRIKVMELLLKHGA 424
           +  + L +A   G+Y++A+VLL   AN   +   G  TPL  A     + +++LLL H A
Sbjct: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296

Query: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
            + + + +G T +  A   G V+IV  L++ GA+    N  G T L  AA +G  EV R 
Sbjct: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356

Query: 485 LVQDGAQVEAKAKD-DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
           L+  GA +   + +  ++ L ++   G  D+V+ LL+ GA     T   +T L  +  +G
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416

Query: 544 HEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLH 603
           H +VA  LLD GA +++      +PL +AA  G +E+A LL+++ A+ +     G TPL 
Sbjct: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476

Query: 604 VAAHYDNQKVALLLLDQGASPHAAAKNGY-TPLHIAAKKNQMDIATTLLEYGADANAVTR 662
            AA   ++++  LLL QGA+ +A  +    T L +A      ++A  L++ GAD      
Sbjct: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536

Query: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAH 722
             +     A+QEGH+++V  LL   ANV+ +  +G T L  A +    +VA+VL+  GA 
Sbjct: 537 TPLME---ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593

Query: 723 VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN-AKTKNGYTPLHQAAQQGHTHIINV 781
           ++ +++ G TPL      G++  V FL+   A VN A   N +T +  A   GH  ++ +
Sbjct: 594 LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 653

Query: 782 LLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMT--TTTVTE-----KHKM 834
           LL + A P     +G+T L  A + G+ +VV  L       ++  TT V++     + + 
Sbjct: 654 LLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713

Query: 835 NVPETMNEVLDM-----SDDEVRKANAPEML 860
            VP      L M       D   + N+P +L
Sbjct: 714 QVPRVPTHTLAMVVPPQEPDRTSQENSPALL 744



 Score =  197 bits (501), Expect = 2e-49
 Identities = 157/498 (31%), Positives = 245/498 (49%), Gaps = 20/498 (4%)

Query: 2   AHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYL-RAARAGHLEKALDY 60
           +H A Q+      E  ++ +    RK     R   + ++   S L  A  AG+ E A   
Sbjct: 198 SHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVL 257

Query: 61  IKNGVDI-NICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ 119
           +    ++ +  N+  +  L  AS  G++++V  LL  +A+V++ +  GNTAL  A   G 
Sbjct: 258 LAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317

Query: 120 AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLA 178
            ++VKVL+  GAN+   ++NG TPL  AA   H+EV + LLD+GA   + + E   + L 
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377

Query: 179 VALQQGHDQVVSLLLENDTKGKVRLPALHIAARK----DDTKAAALLLQNDNNADVESKS 234
           +A  +GH  +V  LLE     + +   +H A  +       + A LLL +    ++ + S
Sbjct: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437

Query: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294
             +PL +AA  G++ +A LL+ R A ++       TPL  A++ G+  MV LLL +GA I
Sbjct: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497

Query: 295 DAKTRD----GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS-PLHMATQGDHLNC 349
           +A+T +     LT   CG   G  +V + L+   A I    + G S PL  A+Q  HL  
Sbjct: 498 NAQTEETQETALTLACCG---GFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLEL 550

Query: 350 VQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACK 409
           V+ LL     V   T    TAL  A   GH  VA VLL   A+   ++  G TPL  A +
Sbjct: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 610

Query: 410 KNRIKVMELLLKHGASI-QAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468
              +  ++ L+  GA++ +A   +  T + +A   GH+ +V  L+ HGA P      G T
Sbjct: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670

Query: 469 ALHMAARSGQAEVVRYLV 486
            L  AA+ G   VV YL+
Sbjct: 671 MLIEAAKGGHTNVVSYLL 688



 Score =  171 bits (434), Expect = 1e-41
 Identities = 197/816 (24%), Positives = 347/816 (42%), Gaps = 97/816 (11%)

Query: 46   LRAARAGHLEKALDYIKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAAT 104
            + AA AGH+E A   + +G  IN   N+   +AL LA  +GH+++V  LL+  A+ +  T
Sbjct: 343  MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKT 402

Query: 105  KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
             + +TAL  A + G  EV ++L+ +GA VN  + +  +PL +AA   H+E+   L++ GA
Sbjct: 403  DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 462

Query: 165  SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN 224
            +     ++G+TPL  A ++GH+++V+LLL             +I A+ ++T+  AL L  
Sbjct: 463  NLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQETALTL-- 511

Query: 225  DNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMV 284
                             A   G   VA  L+   A ++       TPL  AS+ G+  +V
Sbjct: 512  -----------------ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELV 551

Query: 285  KLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQG 344
            K LL  GA + A T  G T L     +GH  V ++LL   A +  +++ G +PL  A + 
Sbjct: 552  KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARA 611

Query: 345  DHLNCVQLLLQHNVPVDDVT-NDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTP 403
             HL  VQ L+     V+  T N+  T + +A   GH  V ++LL   A+P  +  +G T 
Sbjct: 612  GHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTM 671

Query: 404  LHIACKKNRIKVMELLLKHGASIQAVTESGLT---------------PIHVAAFMGHVNI 448
            L  A K     V+  LL +  ++ +V  + ++               P H  A +    +
Sbjct: 672  LIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMV----V 727

Query: 449  VSQLMHHGASPNT---------TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
              Q     +  N+         T+ +  ++L +A +        Y   +    E + K +
Sbjct: 728  PPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVEETEGKLN 787

Query: 500  QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559
            +    ISA + KA +    L QG   N               +  + +   L      L 
Sbjct: 788  ELGQRISA-IEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQKVERQLQ 846

Query: 560  ITTKKGFTPLHVAAKYGKLEVANLLLQ---KSASPDAAGKSGLTPLHVAAHYDNQKVALL 616
            + T++ FT  ++  K G+ +  +L  Q   +   P+  G   L   H +   +  +V  +
Sbjct: 847  MKTQQQFTKEYLETK-GQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFS---ELPQVDTI 902

Query: 617  LL------DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 670
            L       D+  SP +A +  + P+          +++    + +D  +    G  S+ L
Sbjct: 903  LFKDNDVDDEQQSPPSAEQIDFVPV--------QPLSSPQCNFSSDLGS---NGTNSLEL 951

Query: 671  AAQEGHVDMVS----LLLGRNANVNLSNKSGL---TPLHLAAQ--EDRVNVAEVLVNQGA 721
                G+  +V      + G +  + +    GL   TP        +D +      V  G+
Sbjct: 952  QKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGS 1011

Query: 722  HVDAQTKMGYTPLHVGCHYGNIKIVNF-LLQHSAKVNAKTKNGY-TPLHQAAQQGHTHII 779
            +  +QT    TP        N+   +   +  S  ++A T++ + T L  A   GH  ++
Sbjct: 1012 NSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELV 1071

Query: 780  NVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
            +VL+  +A        G T L +A   G++ VV+ L
Sbjct: 1072 SVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107



 Score =  166 bits (421), Expect = 4e-40
 Identities = 137/467 (29%), Positives = 209/467 (44%), Gaps = 48/467 (10%)

Query: 73   NGLNALHLASKEGHVEVVSE------------LLQREANVDAATKKGNTALHIASLAGQA 120
            NG N+L L    G+ ++V +            L+Q    +  AT        +  L    
Sbjct: 944  NGTNSLELQKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIA-- 1001

Query: 121  EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180
              V   V  G+N ++Q+    TP          E       N ASQS+        +   
Sbjct: 1002 -AVSTRVPTGSNSSSQTTECLTP----------ESCSQTTSNVASQSMPPVYPSVDIDAH 1050

Query: 181  LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH 240
             +  HD                  AL +A      +  ++L+  D   +   K GFTPL 
Sbjct: 1051 TESNHDT-----------------ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLI 1093

Query: 241  IAAHYGNINVATLLLNRAAAVDFTA-RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTR 299
            +AA  G++ V  +LL++   ++  + R   TPL +A   G   +V LLL RGA  + +  
Sbjct: 1094 LAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNV 1153

Query: 300  DGLTPLHCGARSGHEQVVEMLLDRAAPILSKT--KNGLSPLHMATQGDHLNCVQLLLQHN 357
               TPL   A  G+  ++++LL+  A I S+T  K G+SPL +A    H+  V+LLL   
Sbjct: 1154 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213

Query: 358  VPVD-DVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVM 416
              ++  +  +  TAL +A   G  +V  +LLD+KAN   +A  G TPL  A      +V 
Sbjct: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1273

Query: 417  ELLLKHGASIQA--VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAA 474
             +LL  GA + A  V  S  T + +AA  GH      L+H GA  +  N +G T L +A+
Sbjct: 1274 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333

Query: 475  RSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521
              G  +VV+ LVQ GA V+A      TPL  + R G   +VQ L+++
Sbjct: 1334 NGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score =  157 bits (397), Expect = 2e-37
 Identities = 126/408 (30%), Positives = 196/408 (48%), Gaps = 48/408 (11%)

Query: 34   DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93
            D   +S+ + +   A   GH E     I     I   ++ G   L LA+  GHV VV  L
Sbjct: 1048 DAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107

Query: 94   LQREANVDAATKK-GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENH 152
            L +  +++A +++  +T L +A   G+ EVV +L+  GAN   ++ + +TPL +AA   +
Sbjct: 1108 LDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGY 1167

Query: 153  LEVVKFLLDNGASQSLATED--GFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAA 210
            + ++K LL+ GA  +  T    G +PL +A   GH   V LLL+                
Sbjct: 1168 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD---------------- 1211

Query: 211  RKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDIT 270
                       + +D NA +E+    T L +A   G   V +LLL+R A V+  A+  +T
Sbjct: 1212 -----------MGSDINAQIETNRN-TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLT 1259

Query: 271  PLHVASKRGNANMVKLLLDRGAKIDA----KTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326
            PL  A+  G A + ++LLD+GA ++A     +RD  T L   A  GH +  E+L+ R A 
Sbjct: 1260 PLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAH 1317

Query: 327  ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
            I  + K G +PL +A+ G H + VQLL+Q    VD   N  +T L  A   GH KV + L
Sbjct: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL 1377

Query: 387  LDKKANPNAKALNGFTPLHIACKK--NRIKVMELLLKHGASIQAVTES 432
            +        K +N F P  I C +    I   ELL K    ++ + ++
Sbjct: 1378 V--------KEVNQF-PSDIECMRYIATITDKELLKKCHQCVETIVKA 1416



 Score =  147 bits (371), Expect = 2e-34
 Identities = 101/338 (29%), Positives = 173/338 (51%), Gaps = 7/338 (2%)

Query: 462  TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521
            T    +TAL +A   G  E+V  L+   A++E + K   TPL ++A  G   +V+ LL +
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110

Query: 522  GASPNAATT-SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEV 580
            G    A +  +  TPL L+   G ++V   LL  GA+        +TPL +AA  G + +
Sbjct: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170

Query: 581  ANLLLQKSASPDA--AGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAK-NGYTPLHI 637
              +LL   A  ++    K G++PL +AA   +     LLLD G+  +A  + N  T L +
Sbjct: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230

Query: 638  AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSN--K 695
            A  + + ++ + LL+  A+     + G+  +  AA  G+ ++  +LL + A+VN      
Sbjct: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290

Query: 696  SGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK 755
            S  T L +AA +      E+L+++GAH+D + K G TPL +  + G+  +V  L+Q  A 
Sbjct: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350

Query: 756  VNAKTKNGYTPLHQAAQQGHTHIINVLLQN-NASPNEL 792
            V+A      TPL  A ++GH  ++  L++  N  P+++
Sbjct: 1351 VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDI 1388



 Score =  145 bits (366), Expect = 9e-34
 Identities = 114/369 (30%), Positives = 178/369 (48%), Gaps = 14/369 (3%)

Query: 501  TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560
            T L ++   G  ++V  L+ + A        G+TPL L+A  GH  V   LLD G  +  
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 561  TTKKGF-TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619
             +++   TPL +A   G+ EV +LLL + A+ +    S  TPL +AA      +  +LL+
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176

Query: 620  QGA--SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA-VTRQGIASVHLAAQEGH 676
             GA  +    +K G +PL +AA    +     LL+ G+D NA +      ++ LA  +G 
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236

Query: 677  VDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY--TPL 734
             ++VSLLL R ANV    K+GLTPL  AA      V  VL+++GA V+A        T L
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296

Query: 735  HVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTV 794
             +    G+ K    L+   A ++ + K G TPL  A+  GH  ++ +L+Q  A  +    
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356

Query: 795  NGNTALGIARRLGYISVVDTL-KIVTE-----ETMT-TTTVTEKHKM-NVPETMNEVLDM 846
               T L  A R G++ VV  L K V +     E M    T+T+K  +    + +  ++  
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKA 1416

Query: 847  SDDEVRKAN 855
             D +  +AN
Sbjct: 1417 KDQQAAEAN 1425



 Score =  134 bits (337), Expect = 2e-30
 Identities = 105/317 (33%), Positives = 160/317 (50%), Gaps = 10/317 (3%)

Query: 34  DRKKKSDA-NASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSE 92
           D++ K+D  + + + A   GH+E A   + +G  +N+   +  + L LA+  GHVE+ + 
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456

Query: 93  LLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGF-TPLYMAAQEN 151
           L++R AN++    +G T L  A+  G  E+V +L+  GAN+NAQ++    T L +A    
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516

Query: 152 HLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLP----ALH 207
             EV  FL+  GA   L      TPL  A Q+GH ++V  LL +             AL 
Sbjct: 517 FSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573

Query: 208 IAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVD-FTAR 266
            A     T  A +LLQ   + + ES+ G TPL  AA  G++     L+++ A V+  TA 
Sbjct: 574 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATAN 633

Query: 267 NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326
           ND T + +A   G+  +V+LLL  GA    + +DG T L   A+ GH  VV  LLD    
Sbjct: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693

Query: 327 ILSKTKNGLSPLHMATQ 343
           +LS     +S L   +Q
Sbjct: 694 VLSVPTTDVSQLPPPSQ 710



 Score = 87.4 bits (215), Expect = 3e-16
 Identities = 65/203 (32%), Positives = 99/203 (48%), Gaps = 15/203 (7%)

Query: 670  LAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729
            LA   GH ++VS+L+ R+A +   +K G TPL LAA    V V E+L+++G  ++AQ++ 
Sbjct: 1061 LACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSER 1120

Query: 730  GY-TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788
               TPL + C  G  ++V+ LL   A    +  + YTPL  AA  G+ +II +LL   A 
Sbjct: 1121 TKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 1180

Query: 789  PNELTVN--GNTALGIARRLGYISVVDTLKIVTE------ETMTTTTVTEKHKMNVPETM 840
             N  T +  G + L +A   G++  V  L  +        ET   T +T        E +
Sbjct: 1181 INSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVV 1240

Query: 841  NEVLDMSDDEVRKANAPEMLSDG 863
            + +LD      RKAN       G
Sbjct: 1241 SLLLD------RKANVEHRAKTG 1257



 Score = 35.4 bits (80), Expect = 1.3
 Identities = 47/181 (25%), Positives = 79/181 (43%), Gaps = 16/181 (8%)

Query: 1508 TAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISDV 1567
            + PITV     +    L  +++ TPS+   +    V   SP  +T+ +S TS+  S+  V
Sbjct: 1932 SCPITVSSVVAAS-QQLCVTNTRTPSSVRKQLFACVPKTSP-PATVISSVTSTCSSLPSV 1989

Query: 1568 AS-PIRSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAV----TEATPLKGLA--SNSTF 1620
            +S PI S +  ++ +    SQ+  + Q      A  P      T+  P+  L   S++  
Sbjct: 1990 SSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMANLCTPSSTAN 2049

Query: 1621 SSRTSPVTTAGSLLERSSITMTPPAS-------PKSNINMYSSSLPFKSIITSAAPLISS 1673
            S  +S   T G+     S + TP +S       P S  ++   S+PF S    A   ++S
Sbjct: 2050 SCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNSEPAPLTLTS 2109

Query: 1674 P 1674
            P
Sbjct: 2110 P 2110



 Score = 35.4 bits (80), Expect = 1.3
 Identities = 36/140 (25%), Positives = 60/140 (42%), Gaps = 13/140 (9%)

Query: 1523 SLSSSSSNTPSASPLKSIWSVSTPSPIKS-TLGASTTSSVKSISDVASPIRSFRTMSSPI 1581
            S SSS+SNTP A         S+P+P  S T   +  SSV  +S ++ P   F + S P 
Sbjct: 2050 SCSSSASNTPGAPETHPS---SSPTPTSSNTQEEAQPSSVSDLSPMSMP---FASNSEPA 2103

Query: 1582 KTVVSQSPYNIQVSSGTLARAPAVTEATPLKG--LASNSTFSSRTSPVTT---AGSLLER 1636
               ++ SP  +   +   +  P +    P     +    +F S     T      S+   
Sbjct: 2104 PLTLT-SPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIFVT 2162

Query: 1637 SSITMTPPASPKSNINMYSS 1656
            + +T+TPP  P + + + S+
Sbjct: 2163 NPVTLTPPQGPPAAVQLSSA 2182


>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
            [Homo sapiens]
          Length = 1170

 Score =  219 bits (558), Expect = 5e-56
 Identities = 213/821 (25%), Positives = 358/821 (43%), Gaps = 86/821 (10%)

Query: 57   ALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG-NTALHIAS 115
            A   + +  D+++ +++G + LH   + G +   + L++  A V+AAT     T LH+ +
Sbjct: 272  ATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVA 331

Query: 116  L-----------AGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD-NG 163
            L           +  A++ + L+  GAN N Q   G TPL+++    +  V   LL    
Sbjct: 332  LYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQ 391

Query: 164  ASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQ 223
                L   +G T L +A+Q      +++  +        +P ++     D+   AA L+Q
Sbjct: 392  LDLELKDHEGSTALWLAVQH-----ITVSSDQSVNPFEDVPVVN-GTSFDENSFAARLIQ 445

Query: 224  NDNNADV-ESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNAN 282
              ++ D  ++ +G   L  AA  GN   A  L    A V+   +   TPLH A + G AN
Sbjct: 446  RGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLAN 505

Query: 283  MVKLLLDRGAKIDAKTRDGL-------------------TPLHCGARSGHEQVVEMLLDR 323
            +   LL +GA  + +T + L                   TPLH      H  VV ++L++
Sbjct: 506  LTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQ 565

Query: 324  AAPILSKTKN-------------GLSPLHMAT-QGDHLNCVQLLLQHNVPVDDVTNDYLT 369
             A  L  T N               + L +A   G H    Q LL     ++D  +D  T
Sbjct: 566  KANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQ-LLGSGAAINDTMSDGQT 624

Query: 370  ALHVAAHCGHYKVAKVLLDKKANPN-AKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
             LH+A      K A  LL+ +A+ N ++  +G T L +A +     V++ +   GA +  
Sbjct: 625  LLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSV 684

Query: 429  VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG----ETALHMAARSGQAEVVRY 484
              E G  P+ +A      +I S L+ HG              +T LH A          +
Sbjct: 685  PDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACF 744

Query: 485  LVQDGAQV------------EAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532
            L++ G  V            E +A+D QTPLH++A  G  + VQ LL+ GA+ NA    G
Sbjct: 745  LIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEG 804

Query: 533  YTPLHLSAREGHEDVAAFLLDH-GASLSITTKKGFTPLHVAAKYGKLEVANLLLQK-SAS 590
             TP+H++    H  +   L+ H    L++  ++G TP   A  +   + A  +L++ S +
Sbjct: 805  RTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGA 864

Query: 591  PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG--YTPLHIAAKKNQMDIAT 648
             +     G   LHVA    + +  L L+   A+ ++  ++    TPLH+A +     I  
Sbjct: 865  AEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVR 924

Query: 649  TLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQED 708
             LL  GA  N +T+    ++HLAAQ+    + S+LL    +    +++G   LHLA    
Sbjct: 925  NLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHG 984

Query: 709  RVNVAEVLVNQGAHVDAQ--TKMGYTPLHVGCHYGN---IKIVNFLLQ--HSAKVNAKTK 761
            R+N   VL+ +   VDA+     G +PLH+   YG      I +  L+      ++    
Sbjct: 985  RLNNIRVLLTE-CTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDA 1043

Query: 762  NGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGI 802
            +G T L  A  +G+ ++   ++++ A    L VN N  + I
Sbjct: 1044 DGSTVLLLAYMKGNANLCRAIVRSGA---RLGVNNNQGVNI 1081



 Score =  215 bits (548), Expect = 7e-55
 Identities = 215/831 (25%), Positives = 337/831 (40%), Gaps = 135/831 (16%)

Query: 67   INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126
            +N  + NG  AL LA       + + L+  +A+VD   K G + LH     G       L
Sbjct: 249  LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308

Query: 127  VTNGANVNAQSQNGF-TPLYMAA-----------QENHLEVVKFLLDNGASQSLATEDGF 174
            + NGA VNA +     TPL++ A                ++ + LL  GA+ ++    G 
Sbjct: 309  IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368

Query: 175  TPLAVALQQGHDQVVSLLLE--------NDTKGKVRL--PALHIAARKD----------- 213
            TPL V++  G++ V S LL+         D +G   L     HI    D           
Sbjct: 369  TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPV 428

Query: 214  -------DTKAAALLLQNDNNADV-ESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265
                   +   AA L+Q  ++ D  ++ +G   L  AA  GN   A  L    A V+   
Sbjct: 429  VNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRN 488

Query: 266  RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGL-------------------TPLH 306
            +   TPLH A + G AN+   LL +GA  + +T + L                   TPLH
Sbjct: 489  KWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLH 548

Query: 307  CGARSGHEQVVEMLLDRAAPILSKTKN-------------GLSPLHMAT-QGDHLNCVQL 352
                  H  VV ++L++ A  L  T N               + L +A   G H    QL
Sbjct: 549  MAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQL 608

Query: 353  LLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN-AKALNGFTPLHIACKKN 411
            L      ++D  +D  T LH+A      K A  LL+ +A+ N ++  +G T L +A +  
Sbjct: 609  L-GSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQ 667

Query: 412  RIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG----E 467
               V++ +   GA +    E G  P+ +A      +I S L+ HG              +
Sbjct: 668  LPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQ 727

Query: 468  TALHMAARSGQAEVVRYLVQDGAQV------------EAKAKDDQTPLHISARLGKADIV 515
            T LH A          +L++ G  V            E +A+D QTPLH++A  G  + V
Sbjct: 728  TLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETV 787

Query: 516  QQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH-GASLSITTKKGFTP------ 568
            Q LL+ GA+ NA    G TP+H++    H  +   L+ H    L++  ++G TP      
Sbjct: 788  QCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMT 847

Query: 569  ----------------------------LHVAAKYGKLEVANLLLQKSASPDAAGK--SG 598
                                        LHVA +   +E    L+   A+ ++  +  S 
Sbjct: 848  FKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASK 907

Query: 599  LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN 658
            LTPLH+A    ++ +   LL  GA  +   K+  T LH+AA+++   I + LLE G D  
Sbjct: 908  LTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFA 967

Query: 659  AVTRQGIASVHLAAQEGHVDMVSLLLGR-NANVNLSNKSGLTPLHLAAQEDRVNVAEVL- 716
            AV   G  ++HLA   G ++ + +LL     +    N  G +PLH+  Q  + N A +  
Sbjct: 968  AVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFD 1027

Query: 717  ----VNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNG 763
                   G  +D     G T L +    GN  +   +++  A++      G
Sbjct: 1028 LFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078



 Score =  187 bits (475), Expect = 2e-46
 Identities = 206/774 (26%), Positives = 322/774 (41%), Gaps = 136/774 (17%)

Query: 176 PLAVALQQGHDQVVSL-LLENDTK--GKVRLP------ALHIAARKDDTKAAALLLQNDN 226
           PL  A++   + VV L L+E D++  GK+         AL +A  +     A  L+ +  
Sbjct: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280

Query: 227 NADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDF-TARNDITPLHV----ASKRGNA 281
           + D+  KSG++ LH     G++  AT L+   A V+  T     TPLH+    +SK+ +A
Sbjct: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340

Query: 282 NMV-------KLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLD-RAAPILSKTKN 333
           +++       + LL  GA  + +   G TPLH    +G+E V   LL  +   +  K   
Sbjct: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHE 400

Query: 334 GLSPLHMATQG-----------------------DHLNCVQLLLQ---HNVPVDDVTNDY 367
           G + L +A Q                        D  +    L+Q   H    D  T + 
Sbjct: 401 GSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNC 460

Query: 368 LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQ 427
           L  L  AA  G+   A  L    A+ N +   G TPLH AC+     +   LL+ GA+  
Sbjct: 461 L--LQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPN 518

Query: 428 AVTESGL-------------------TPIHVAAFMGHVNIVSQLMHHGASP--NTTNV-- 464
             TE  L                   TP+H+A    H ++VS ++   A+    T N+  
Sbjct: 519 LQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQI 578

Query: 465 ---------RGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIV 515
                    R +T L +A  +G   +   L+  GA +     D QT LH++ +   +   
Sbjct: 579 IPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSA 638

Query: 516 QQLLQQGASPNAATTS-GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 574
             LL+  A  N + T  G T L L+ R     V   +   GA +S+  +KG  PL +A  
Sbjct: 639 LFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALA 698

Query: 575 YGKLEVANLLLQKSASPDAAGKSG----LTPLHVAAHYDNQKVALLLLDQGASPHAA--- 627
               ++A+ L++        G        T LH A   +N+  A  L+  G   ++    
Sbjct: 699 NNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQP 758

Query: 628 ---------AKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVD 678
                    A++G TPLH+AA     +    LLE+GA+ NA   +G   +H+A    H  
Sbjct: 759 GANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGV 818

Query: 679 MVSLLLGR-NANVNLSNKSGLTP----------------------------------LHL 703
           ++ LL+   + ++N+ ++ GLTP                                  LH+
Sbjct: 819 IIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHV 878

Query: 704 AAQEDRVNVAEVLVNQGAHVDA--QTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTK 761
           A Q   +     L++  A+V++  Q     TPLH+    G+  IV  LL   AKVN  TK
Sbjct: 879 AVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTK 938

Query: 762 NGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
           +  T LH AAQQ    I +VLL+N      +  NGN AL +A   G ++ +  L
Sbjct: 939 HRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVL 992



 Score =  142 bits (358), Expect = 7e-33
 Identities = 150/590 (25%), Positives = 249/590 (42%), Gaps = 90/590 (15%)

Query: 34   DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93
            D    +  N    RAA AG+   AL    NG  +N  N+ G   LH A + G   + +EL
Sbjct: 451  DAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAEL 510

Query: 94   LQREANVDAATKKG-NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENH 152
            LQ+ AN +  T++        ASL   A+ V +                TPL+MA   NH
Sbjct: 511  LQQGANPNLQTEEALPLPKEAASLTSLADSVHLQ---------------TPLHMAIAYNH 555

Query: 153  LEVVKFLLDNGASQSLATED-------------GFTPLAVALQQGHDQVVSLLLE----- 194
             +VV  +L+  A+   AT +               T L +AL  G   + + LL      
Sbjct: 556  PDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAI 615

Query: 195  NDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADV-ESKSGFTPLHIAAHYGNINVATL 253
            NDT    +   LH+A ++ D+K+A  LL++  + +V  ++ G T L +A       V   
Sbjct: 616  NDTMSDGQ-TLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDA 674

Query: 254  LLNRAAAVD-----------FTARNDI--------------------------TPLHVAS 276
            +  R A +                N++                          T LH A 
Sbjct: 675  ICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAI 734

Query: 277  KRGNANMVKLLLDRGAKIDA------------KTRDGLTPLHCGARSGHEQVVEMLLDRA 324
               N      L+  G  +++            + RDG TPLH  A  G E+ V+ LL+  
Sbjct: 735  DENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFG 794

Query: 325  APILSKTKNGLSPLHMATQGDHLNCVQLLLQH-NVPVDDVTNDYLTALHVAAHCGHYKVA 383
            A + ++   G +P+H+A    H   +QLL+ H ++ ++      LT    A    + K A
Sbjct: 795  ANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSA 854

Query: 384  KVLLDKKANPNAKALN-GFTPLHIACKKNRIKVMELLLKHGASIQAVTE--SGLTPIHVA 440
            + +L +++    +  N G   LH+A + + I+ +  L+   A++ +  +  S LTP+H+A
Sbjct: 855  EAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLA 914

Query: 441  AFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ 500
               G   IV  L+  GA  N      +TALH+AA+     +   L+++G    A  ++  
Sbjct: 915  VQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGN 974

Query: 501  TPLHISARLGKADIVQQLLQQ-GASPNAATTSGYTPLHLSAREGHEDVAA 549
              LH++   G+ + ++ LL +      A    G +PLH+  + G E+ AA
Sbjct: 975  NALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAA 1024



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 41/147 (27%), Positives = 67/147 (45%), Gaps = 3/147 (2%)

Query: 48   AARAGHLEKALDYIKNGVDIN--ICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK 105
            A +   +E  L  I    ++N  + + + L  LHLA + G   +V  LL   A V+  TK
Sbjct: 879  AVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTK 938

Query: 106  KGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS 165
               TALH+A+      +  VL+ NG +  A  +NG   L++A     L  ++ LL     
Sbjct: 939  HRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTV 998

Query: 166  QSLATE-DGFTPLAVALQQGHDQVVSL 191
             + A    G +PL +  Q G +   ++
Sbjct: 999  DAEAFNLRGQSPLHILGQYGKENAAAI 1025


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  192 bits (488), Expect = 6e-48
 Identities = 123/337 (36%), Positives = 174/337 (51%), Gaps = 4/337 (1%)

Query: 360 VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELL 419
           VD   +   + LH+A   G  + AK LL   ANPN     G TPLH+A ++    V+ELL
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELL 490

Query: 420 LKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQA 479
           L    S+ A  E   T +H AA  G  +    L+   AS N  +  G T +H+A + GQ 
Sbjct: 491 LARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550

Query: 480 EVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ-GASPNAATTSGYTPLHL 538
            +VR L++ G  V  + KD   PLH +A  G   IV+ L +Q G S NA T  G TPLHL
Sbjct: 551 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHL 610

Query: 539 SAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSG 598
           +A+ GH  VA  L+D  + +++ +    TPLHVAA+ G    A LLL + A  +A    G
Sbjct: 611 AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG 670

Query: 599 LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA- 657
            T LH+AA   +     LL+++ A   A      T LH+AA     ++   L+   AD  
Sbjct: 671 YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV--SADVI 728

Query: 658 NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSN 694
           +    QG++++HLAAQ  H   V  LL   A++NL +
Sbjct: 729 DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS 765



 Score =  184 bits (466), Expect = 2e-45
 Identities = 119/357 (33%), Positives = 177/357 (49%), Gaps = 7/357 (1%)

Query: 414 KVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473
           K+M++L      +    +SG + +H+A   G       L+ + A+PN +N RG T LHMA
Sbjct: 421 KLMKILQPQ--DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMA 478

Query: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
                  VV  L+     V AK +D  T LH +A+ G     + LL++ AS N     G 
Sbjct: 479 VERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGR 538

Query: 534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL-QKSASPD 592
           TP+H++ + G E++   LL  G  +S+  K  + PLH AA  G L +  LL  Q   S +
Sbjct: 539 TPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVN 598

Query: 593 AAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLE 652
           A    G TPLH+AA   + +VA +L+D  +  +  +    TPLH+AA+      A  LL 
Sbjct: 599 AQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLH 658

Query: 653 YGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNV 712
            GA   A+T  G  ++HLAA+ GH+  V LL+   A+V        T LHLAA      V
Sbjct: 659 RGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEV 718

Query: 713 AEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN---AKTKNGYTP 766
            E LV+    +D   + G + LH+     + + V  LL+H A +N    K + G+ P
Sbjct: 719 VEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774



 Score =  179 bits (454), Expect = 5e-44
 Identities = 113/331 (34%), Positives = 166/331 (50%), Gaps = 4/331 (1%)

Query: 294 IDAKTRDGLTPLHCGARSGHEQVVE-MLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQL 352
           +D     G + LH    +G E+  + +LL+ A P LS  + G +PLHMA +      V+L
Sbjct: 431 VDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSN-RRGSTPLHMAVERRVRGVVEL 489

Query: 353 LLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNR 412
           LL   + V+    D  TALH AA  G     ++LL+K A+ N     G TP+H+AC+  +
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549

Query: 413 IKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH-GASPNTTNVRGETALH 471
             ++ +LL+ G  +    +    P+H AA+ GH+ IV  L    G S N   + G T LH
Sbjct: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLH 609

Query: 472 MAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS 531
           +AA+ G   V R L+   + V   +   QTPLH++A  G     + LL +GA   A T+ 
Sbjct: 610 LAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD 669

Query: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591
           GYT LHL+AR GH      L++  A +        T LH+AA +G  EV   L+      
Sbjct: 670 GYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVI- 728

Query: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGA 622
           D   + GL+ LH+AA   + +    LL  GA
Sbjct: 729 DLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759



 Score =  177 bits (448), Expect = 3e-43
 Identities = 110/339 (32%), Positives = 182/339 (53%), Gaps = 6/339 (1%)

Query: 132 NVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSL 191
           +V+    +G + L++A +    E  K+LL N A+ +L+   G TPL +A+++    VV L
Sbjct: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489

Query: 192 LLEN----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGN 247
           LL      + K + +  ALH AA+  D  +  LLL+ + + +     G TP+H+A  +G 
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549

Query: 248 INVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDR-GAKIDAKTRDGLTPLH 306
            N+  +LL R   V    ++   PLH A+ +G+  +VKLL  + G  ++A+T DG TPLH
Sbjct: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLH 609

Query: 307 CGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTND 366
             A+ GH +V  +L+D  + +   +    +PLH+A +  H +  +LLL      + +T+D
Sbjct: 610 LAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD 669

Query: 367 YLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASI 426
             TALH+AA  GH    K+L+++KA+  A+     T LH+A      +V+E L+     I
Sbjct: 670 GYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-I 728

Query: 427 QAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVR 465
               E GL+ +H+AA   H   V  L+ HGA  N  +++
Sbjct: 729 DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767



 Score =  170 bits (430), Expect = 3e-41
 Identities = 110/338 (32%), Positives = 181/338 (53%), Gaps = 6/338 (1%)

Query: 66  DINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKV 125
           D+++   +G + LHLA + G  E    LL   AN + + ++G+T LH+A       VV++
Sbjct: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489

Query: 126 LVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGH 185
           L+    +VNA+ ++ +T L+ AAQ       + LL+  AS +    +G TP+ VA Q G 
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549

Query: 186 DQVVSLLLENDT----KGKVRLPALHIAARKDDTKAAALLLQNDN-NADVESKSGFTPLH 240
           + +V +LL        +GK     LH AA +       LL +    + + ++  G TPLH
Sbjct: 550 ENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLH 609

Query: 241 IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD 300
           +AA  G+  VA +L++  + V+  +    TPLHVA++ G+ +  +LLL RGA  +A T D
Sbjct: 610 LAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD 669

Query: 301 GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPV 360
           G T LH  AR+GH   V++L++  A +L++     + LH+A    H   V+ L+  +V +
Sbjct: 670 GYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-I 728

Query: 361 DDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKAL 398
           D      L+ALH+AA   H +  + LL   A+ N ++L
Sbjct: 729 DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766



 Score =  170 bits (430), Expect = 3e-41
 Identities = 101/326 (30%), Positives = 164/326 (50%), Gaps = 2/326 (0%)

Query: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 525
           G + LH+A  +GQ E  ++L+ + A      +   TPLH++       +V+ LL +  S 
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497

Query: 526 NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL 585
           NA     +T LH +A+ G E     LL+  AS++    +G TP+HVA ++G+  +  +LL
Sbjct: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557

Query: 586 QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ-GASPHAAAKNGYTPLHIAAKKNQM 644
           ++       GK    PLH AA   +  +  LL  Q G S +A   +G TPLH+AA++   
Sbjct: 558 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 617

Query: 645 DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLA 704
            +A  L++  +D N  +      +H+AA+ GH     LLL R A        G T LHLA
Sbjct: 618 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677

Query: 705 AQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGY 764
           A+   +   ++LV + A V A+  +  T LH+   +G+ ++V  L+     ++   + G 
Sbjct: 678 ARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGL 736

Query: 765 TPLHQAAQQGHTHIINVLLQNNASPN 790
           + LH AAQ  H   +  LL++ A  N
Sbjct: 737 SALHLAAQGRHAQTVETLLRHGAHIN 762



 Score =  165 bits (417), Expect = 1e-39
 Identities = 99/314 (31%), Positives = 160/314 (50%), Gaps = 2/314 (0%)

Query: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562
           LH++   G+ +  + LL   A+PN +   G TPLH++       V   LL    S++   
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501

Query: 563 KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGA 622
           +  +T LH AA+ G      LLL+K+AS +     G TP+HVA  +  + +  +LL +G 
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV 561

Query: 623 SPHAAAKNGYTPLHIAAKKNQMDIATTLLEY-GADANAVTRQGIASVHLAAQEGHVDMVS 681
                 K+ + PLH AA +  + I   L +  G   NA T  G   +HLAAQ GH  +  
Sbjct: 562 DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVAR 621

Query: 682 LLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYG 741
           +L+   ++VN+ +    TPLH+AA+    + A +L+++GA  +A T  GYT LH+    G
Sbjct: 622 ILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNG 681

Query: 742 NIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALG 801
           ++  V  L++  A V A+     T LH AA  GH+ ++  L+  +   +     G +AL 
Sbjct: 682 HLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVI-DLFDEQGLSALH 740

Query: 802 IARRLGYISVVDTL 815
           +A +  +   V+TL
Sbjct: 741 LAAQGRHAQTVETL 754



 Score =  107 bits (266), Expect = 3e-22
 Identities = 69/208 (33%), Positives = 104/208 (50%), Gaps = 3/208 (1%)

Query: 609 DNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASV 668
           D  K+  +L  Q      A  +G + LH+A +  Q + A  LL   A+ N   R+G   +
Sbjct: 418 DTSKLMKILQPQDVD--LALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475

Query: 669 HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 728
           H+A +     +V LLL R  +VN  ++   T LH AAQ    +   +L+ + A V+    
Sbjct: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535

Query: 729 MGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL-QNNA 787
            G TP+HV C +G   IV  LL+    V+ + K+ + PLH AA QGH  I+ +L  Q   
Sbjct: 536 EGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV 595

Query: 788 SPNELTVNGNTALGIARRLGYISVVDTL 815
           S N  T++G T L +A + G+  V   L
Sbjct: 596 SVNAQTLDGRTPLHLAAQRGHYRVARIL 623



 Score = 60.5 bits (145), Expect = 4e-08
 Identities = 40/119 (33%), Positives = 61/119 (51%), Gaps = 5/119 (4%)

Query: 28  HRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHV 87
           HR   ++        A +L AAR GHL      ++   D+         ALHLA+  GH 
Sbjct: 658 HRGAGKEAMTSDGYTALHL-AARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHS 716

Query: 88  EVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS---QNGFTP 143
           EVV EL+  +  +D   ++G +ALH+A+    A+ V+ L+ +GA++N QS   Q G  P
Sbjct: 717 EVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGP 774


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  190 bits (482), Expect = 3e-47
 Identities = 151/519 (29%), Positives = 235/519 (45%), Gaps = 36/519 (6%)

Query: 305 LHCGARSGHEQVVEMLLDRAAPILSKTKN-GLSPLHMATQGDHLNCVQLLLQHNVPVDDV 363
           +H  A +G +  ++ L+   + +  K    G +PL      D L+C   LL+    V+  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 364 TNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHG 423
            +   TALH+AA  G+Y+  K+LL ++AN   K L   TPLH+  +    K + LLLK  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 424 ASIQAVTE--SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEV 481
           A  +  T+  +  T +H +A+  +   V  L+ H ++    +V G+  LH AA       
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH----- 192

Query: 482 VRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAR 541
                            D + +H    +  A   + LL      N     G TPLH +  
Sbjct: 193 ----------------KDPSAVHTVRCILDAAPTESLL------NWQDYEGRTPLHFAVA 230

Query: 542 EGHEDVAAFLLDHGASLSITTKKGF--TPLHVAAKYGKLEVANLLLQKSASPDAAGKS-G 598
           +G+  V   L  +  S +IT+      TPLH AA  G  ++ +LLL+++ S      S G
Sbjct: 231 DGNVTVVDVLTSY-ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQG 289

Query: 599 LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA- 657
            TPLH AA  +  +   + L   +    +   G T    AA K   D+  T+L   +D  
Sbjct: 290 ATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID 349

Query: 658 -NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716
            N   + G  ++H AA  GHV  V LLL  NA V+ ++    TPL  A +    +V + L
Sbjct: 350 INMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTL 409

Query: 717 VNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHT 776
           +  GA VD   + G++ LH     GN  +   L+++    N +   G TPL  AA  G+ 
Sbjct: 410 IKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYI 469

Query: 777 HIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
           + + VL++NNA PN     G TAL  +   GY+  +  L
Sbjct: 470 NCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLL 508



 Score =  187 bits (476), Expect = 2e-46
 Identities = 162/579 (27%), Positives = 256/579 (44%), Gaps = 61/579 (10%)

Query: 78  LHLASKEGHVEVVSELLQ-REANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
           +H A+  G    +  L+    A  D   + G T L    LA + +    L+  GA+VN  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 137 SQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL--- 193
             +  T L++AAQ+ +   +K LL   A+      +  TPL +  +    + ++LLL   
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 194 ---ENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGN--- 247
              E DT+ K +  ALH +A  ++ +   LL+++D+N  +    G  PLH AA++ +   
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 248 INVATLLLNRAAAVDFTARNDI---TPLHVASKRGNANMVKLLLD-RGAKIDAKTRDGLT 303
           ++    +L+ A         D    TPLH A   GN  +V +L       I +      T
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257

Query: 304 PLHCGARSGHEQVVEMLLDR-AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDD 362
           PLH  A  GH Q+V +LL+R  +  +     G +PLH A Q +    V++ L+H    DD
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317

Query: 363 V---------------TNDYL--------------------TALHVAAHCGHYKVAKVLL 387
                           ++D L                    TALH AA  GH    K+LL
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377

Query: 388 DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 447
           +  A  +A  +   TPL  AC+     V++ L+K GA +  V + G + +H AA  G+ +
Sbjct: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437

Query: 448 IVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISA 507
           +   L+ +  +PN  +  G T L  AA  G    +  L+++ A    + K+ +T LH S 
Sbjct: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSC 497

Query: 508 RLGKADIVQQLLQQGASPNAATTS--GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKG 565
             G  D ++ LL   A PN    +   YTPL  +      +V  F+L+HGA LSI   + 
Sbjct: 498 NNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA-LSIAAIQD 556

Query: 566 FTPLHVAAKYGKLEV-------ANLLLQ-KSASPDAAGK 596
                + A Y   +V        NLL++ +    DAA K
Sbjct: 557 IAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAK 595



 Score =  183 bits (465), Expect = 3e-45
 Identities = 156/542 (28%), Positives = 247/542 (45%), Gaps = 25/542 (4%)

Query: 111 LHIASLAG-QAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLA 169
           +H A++ G +  + +++V N A  + + Q G TPL      + L+    LL  GA  +  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 170 TEDGFTPLAVALQQGHDQVVSLLLENDT----KGKVRLPALHIAARKDDTKAAALLLQ-- 223
                T L +A Q+G+ + + LLL        K    +  LH+  R    K  ALLL+  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 224 NDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGN--- 280
                D + K+  T LH +A+Y N     LL+   + +         PLH A+   +   
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 281 ANMVKLLLDRG---AKIDAKTRDGLTPLHCGARSGHEQVVEMLLD-RAAPILSKTKNGLS 336
            + V+ +LD     + ++ +  +G TPLH     G+  VV++L    +  I S      +
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257

Query: 337 PLHMATQGDHLNCVQLLLQHN----VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
           PLH A    H   V LLL+ N    +P D   +   T LH AA     +  KV L   + 
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSD---SQGATPLHYAAQSNFAETVKVFLKHPSV 314

Query: 393 PNAKALNGFTPLHIACKKNRIKVME--LLLKHGASIQAVTESGLTPIHVAAFMGHVNIVS 450
            +   L G T    A  K    V+   L LK    I    + G T +H AA  GHV+ V 
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374

Query: 451 QLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG 510
            L+ + A  + T+V   T L  A   G  +V++ L++ GA+V+   +D  + LH +A  G
Sbjct: 375 LLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGG 434

Query: 511 KADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLH 570
            AD+ Q L++   +PN    +G TPL  +A  G+ +  A L+++ A  +I  K+G T LH
Sbjct: 435 NADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALH 494

Query: 571 VAAKYGKLEVANLLLQKSASPDAA--GKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
            +   G L+   LLL  +A P+     +   TPL  A   +  +V   +L+ GA   AA 
Sbjct: 495 WSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAI 554

Query: 629 KN 630
           ++
Sbjct: 555 QD 556



 Score =  156 bits (395), Expect = 4e-37
 Identities = 136/500 (27%), Positives = 221/500 (44%), Gaps = 53/500 (10%)

Query: 51  AGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN----------- 99
           A  L+ A   +K G D+N  + +   ALHLA+++G+   +  LL R AN           
Sbjct: 58  ADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTP 117

Query: 100 ------------------------VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNA 135
                                   VD   K   TALH ++     E VK+L+ + +N+  
Sbjct: 118 LHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGI 177

Query: 136 QSQNGFTPLYMAAQE---NHLEVVKFLLDNGASQSLAT---EDGFTPLAVALQQGHDQVV 189
               G  PL+ AA     + +  V+ +LD   ++SL      +G TPL  A+  G+  VV
Sbjct: 178 PDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVV 237

Query: 190 SLLLENDT------KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKS-GFTPLHIA 242
            +L   ++          R P LH AA     +   LLL+ + +  + S S G TPLH A
Sbjct: 238 DVLTSYESCNITSYDNLFRTP-LHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYA 296

Query: 243 AHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD-- 300
           A         + L   +  D +     T    A+ +G+ ++++ +L   + ID    D  
Sbjct: 297 AQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKY 356

Query: 301 GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPV 360
           G T LH  A SGH   V++LL+  A + +      +PL  A +  H + +Q L++    V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416

Query: 361 DDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLL 420
           D V  D  + LH AA  G+  V ++L++ K NPN +   G TPL  A     I  M +L+
Sbjct: 417 DLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM 476

Query: 421 KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPN--TTNVRGETALHMAARSGQ 478
           ++ A      + G T +H +   G+++ +  L+   A PN    N    T L  A    +
Sbjct: 477 ENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGER 536

Query: 479 AEVVRYLVQDGAQVEAKAKD 498
            EV++++++ GA   A  +D
Sbjct: 537 HEVIQFMLEHGALSIAAIQD 556



 Score = 92.4 bits (228), Expect = 9e-18
 Identities = 70/265 (26%), Positives = 124/265 (46%), Gaps = 33/265 (12%)

Query: 40  DANASYLRAARAGHLE--KALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQRE 97
           +   S++ AA  G  +  + +  +K+ +DIN+ ++ G  ALH A+  GHV  V  LL+  
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380

Query: 98  ANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVK 157
           A VDA     +T L  A   G  +V++ L+  GA V+   Q+G + L+ AA   + +V +
Sbjct: 381 AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQ 440

Query: 158 FLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKA 217
            L++N  + ++    G TPL  A   G+   +++L+EN+                     
Sbjct: 441 ILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNA-------------------- 480

Query: 218 AALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND--ITPLHVA 275
                    + +++ K G T LH + + G ++   LLL+ AA  +    N+   TPL  A
Sbjct: 481 ---------DPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYA 531

Query: 276 SKRGNANMVKLLLDRGAKIDAKTRD 300
                  +++ +L+ GA   A  +D
Sbjct: 532 LLGERHEVIQFMLEHGALSIAAIQD 556


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  190 bits (482), Expect = 3e-47
 Identities = 151/519 (29%), Positives = 235/519 (45%), Gaps = 36/519 (6%)

Query: 305 LHCGARSGHEQVVEMLLDRAAPILSKTKN-GLSPLHMATQGDHLNCVQLLLQHNVPVDDV 363
           +H  A +G +  ++ L+   + +  K    G +PL      D L+C   LL+    V+  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 364 TNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHG 423
            +   TALH+AA  G+Y+  K+LL ++AN   K L   TPLH+  +    K + LLLK  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 424 ASIQAVTE--SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEV 481
           A  +  T+  +  T +H +A+  +   V  L+ H ++    +V G+  LH AA       
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH----- 192

Query: 482 VRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAR 541
                            D + +H    +  A   + LL      N     G TPLH +  
Sbjct: 193 ----------------KDPSAVHTVRCILDAAPTESLL------NWQDYEGRTPLHFAVA 230

Query: 542 EGHEDVAAFLLDHGASLSITTKKGF--TPLHVAAKYGKLEVANLLLQKSASPDAAGKS-G 598
           +G+  V   L  +  S +IT+      TPLH AA  G  ++ +LLL+++ S      S G
Sbjct: 231 DGNVTVVDVLTSY-ESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQG 289

Query: 599 LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA- 657
            TPLH AA  +  +   + L   +    +   G T    AA K   D+  T+L   +D  
Sbjct: 290 ATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID 349

Query: 658 -NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716
            N   + G  ++H AA  GHV  V LLL  NA V+ ++    TPL  A +    +V + L
Sbjct: 350 INMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTL 409

Query: 717 VNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHT 776
           +  GA VD   + G++ LH     GN  +   L+++    N +   G TPL  AA  G+ 
Sbjct: 410 IKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYI 469

Query: 777 HIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
           + + VL++NNA PN     G TAL  +   GY+  +  L
Sbjct: 470 NCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLL 508



 Score =  187 bits (476), Expect = 2e-46
 Identities = 162/579 (27%), Positives = 256/579 (44%), Gaps = 61/579 (10%)

Query: 78  LHLASKEGHVEVVSELLQ-REANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
           +H A+  G    +  L+    A  D   + G T L    LA + +    L+  GA+VN  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 137 SQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL--- 193
             +  T L++AAQ+ +   +K LL   A+      +  TPL +  +    + ++LLL   
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 194 ---ENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGN--- 247
              E DT+ K +  ALH +A  ++ +   LL+++D+N  +    G  PLH AA++ +   
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 248 INVATLLLNRAAAVDFTARNDI---TPLHVASKRGNANMVKLLLD-RGAKIDAKTRDGLT 303
           ++    +L+ A         D    TPLH A   GN  +V +L       I +      T
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257

Query: 304 PLHCGARSGHEQVVEMLLDR-AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDD 362
           PLH  A  GH Q+V +LL+R  +  +     G +PLH A Q +    V++ L+H    DD
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDD 317

Query: 363 V---------------TNDYL--------------------TALHVAAHCGHYKVAKVLL 387
                           ++D L                    TALH AA  GH    K+LL
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377

Query: 388 DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 447
           +  A  +A  +   TPL  AC+     V++ L+K GA +  V + G + +H AA  G+ +
Sbjct: 378 ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437

Query: 448 IVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISA 507
           +   L+ +  +PN  +  G T L  AA  G    +  L+++ A    + K+ +T LH S 
Sbjct: 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSC 497

Query: 508 RLGKADIVQQLLQQGASPNAATTS--GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKG 565
             G  D ++ LL   A PN    +   YTPL  +      +V  F+L+HGA LSI   + 
Sbjct: 498 NNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA-LSIAAIQD 556

Query: 566 FTPLHVAAKYGKLEV-------ANLLLQ-KSASPDAAGK 596
                + A Y   +V        NLL++ +    DAA K
Sbjct: 557 IAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAK 595



 Score =  183 bits (465), Expect = 3e-45
 Identities = 156/542 (28%), Positives = 247/542 (45%), Gaps = 25/542 (4%)

Query: 111 LHIASLAG-QAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLA 169
           +H A++ G +  + +++V N A  + + Q G TPL      + L+    LL  GA  +  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 170 TEDGFTPLAVALQQGHDQVVSLLLENDT----KGKVRLPALHIAARKDDTKAAALLLQ-- 223
                T L +A Q+G+ + + LLL        K    +  LH+  R    K  ALLL+  
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 224 NDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGN--- 280
                D + K+  T LH +A+Y N     LL+   + +         PLH A+   +   
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 281 ANMVKLLLDRG---AKIDAKTRDGLTPLHCGARSGHEQVVEMLLD-RAAPILSKTKNGLS 336
            + V+ +LD     + ++ +  +G TPLH     G+  VV++L    +  I S      +
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257

Query: 337 PLHMATQGDHLNCVQLLLQHN----VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
           PLH A    H   V LLL+ N    +P D   +   T LH AA     +  KV L   + 
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGTIPSD---SQGATPLHYAAQSNFAETVKVFLKHPSV 314

Query: 393 PNAKALNGFTPLHIACKKNRIKVME--LLLKHGASIQAVTESGLTPIHVAAFMGHVNIVS 450
            +   L G T    A  K    V+   L LK    I    + G T +H AA  GHV+ V 
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374

Query: 451 QLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG 510
            L+ + A  + T+V   T L  A   G  +V++ L++ GA+V+   +D  + LH +A  G
Sbjct: 375 LLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGG 434

Query: 511 KADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLH 570
            AD+ Q L++   +PN    +G TPL  +A  G+ +  A L+++ A  +I  K+G T LH
Sbjct: 435 NADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALH 494

Query: 571 VAAKYGKLEVANLLLQKSASPDAA--GKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
            +   G L+   LLL  +A P+     +   TPL  A   +  +V   +L+ GA   AA 
Sbjct: 495 WSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAI 554

Query: 629 KN 630
           ++
Sbjct: 555 QD 556



 Score =  156 bits (395), Expect = 4e-37
 Identities = 136/500 (27%), Positives = 221/500 (44%), Gaps = 53/500 (10%)

Query: 51  AGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN----------- 99
           A  L+ A   +K G D+N  + +   ALHLA+++G+   +  LL R AN           
Sbjct: 58  ADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTP 117

Query: 100 ------------------------VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNA 135
                                   VD   K   TALH ++     E VK+L+ + +N+  
Sbjct: 118 LHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGI 177

Query: 136 QSQNGFTPLYMAAQE---NHLEVVKFLLDNGASQSLAT---EDGFTPLAVALQQGHDQVV 189
               G  PL+ AA     + +  V+ +LD   ++SL      +G TPL  A+  G+  VV
Sbjct: 178 PDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVV 237

Query: 190 SLLLENDT------KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKS-GFTPLHIA 242
            +L   ++          R P LH AA     +   LLL+ + +  + S S G TPLH A
Sbjct: 238 DVLTSYESCNITSYDNLFRTP-LHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYA 296

Query: 243 AHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD-- 300
           A         + L   +  D +     T    A+ +G+ ++++ +L   + ID    D  
Sbjct: 297 AQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKY 356

Query: 301 GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPV 360
           G T LH  A SGH   V++LL+  A + +      +PL  A +  H + +Q L++    V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416

Query: 361 DDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLL 420
           D V  D  + LH AA  G+  V ++L++ K NPN +   G TPL  A     I  M +L+
Sbjct: 417 DLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM 476

Query: 421 KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPN--TTNVRGETALHMAARSGQ 478
           ++ A      + G T +H +   G+++ +  L+   A PN    N    T L  A    +
Sbjct: 477 ENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGER 536

Query: 479 AEVVRYLVQDGAQVEAKAKD 498
            EV++++++ GA   A  +D
Sbjct: 537 HEVIQFMLEHGALSIAAIQD 556



 Score = 92.4 bits (228), Expect = 9e-18
 Identities = 70/265 (26%), Positives = 124/265 (46%), Gaps = 33/265 (12%)

Query: 40  DANASYLRAARAGHLE--KALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQRE 97
           +   S++ AA  G  +  + +  +K+ +DIN+ ++ G  ALH A+  GHV  V  LL+  
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380

Query: 98  ANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVK 157
           A VDA     +T L  A   G  +V++ L+  GA V+   Q+G + L+ AA   + +V +
Sbjct: 381 AQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQ 440

Query: 158 FLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKA 217
            L++N  + ++    G TPL  A   G+   +++L+EN+                     
Sbjct: 441 ILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNA-------------------- 480

Query: 218 AALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND--ITPLHVA 275
                    + +++ K G T LH + + G ++   LLL+ AA  +    N+   TPL  A
Sbjct: 481 ---------DPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYA 531

Query: 276 SKRGNANMVKLLLDRGAKIDAKTRD 300
                  +++ +L+ GA   A  +D
Sbjct: 532 LLGERHEVIQFMLEHGALSIAAIQD 556


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  185 bits (469), Expect = 1e-45
 Identities = 132/395 (33%), Positives = 200/395 (50%), Gaps = 12/395 (3%)

Query: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327
           D   L  A   G+ N V+ LLD G  ++  T +G + L     +G+ ++ ++LL   A +
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264

Query: 328 LSKTKNG-LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
             +   G ++PL  A+ G +L+ V+LLL H+  V+  +    TAL  A   G   + KVL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324

Query: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT----ESGLTPIHVAAF 442
           L++ AN      NG TPL  A     ++V  +LL HGA I   +    ES LT   +A +
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACY 381

Query: 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502
            GH+++V  L+  GA          TAL  A   G  EV R L+  GAQV   A   ++P
Sbjct: 382 KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 441

Query: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562
           L ++A  G  ++   L+++GA+       GYTPL  +AREGHE++ A LL  GA+++  T
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501

Query: 563 KK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621
           ++   T L +A   G  EVA+ L++  A  +       TPL  A+   + ++   LL  G
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 558

Query: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD 656
           A+ HA    G T L  A +    D+A  LL+ GAD
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593



 Score =  181 bits (459), Expect = 1e-44
 Identities = 136/427 (31%), Positives = 216/427 (50%), Gaps = 19/427 (4%)

Query: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGD-----------HLNCVQLLLQHNVPVDDVTN 365
           V   LD AA  L++ K   S  H A Q D            +N V+ LL     V++ T 
Sbjct: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236

Query: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG-FTPLHIACKKNRIKVMELLLKHGA 424
           +  + L +A   G+Y++A+VLL   AN   +   G  TPL  A     + +++LLL H A
Sbjct: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296

Query: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
            + + + +G T +  A   G V+IV  L++ GA+    N  G T L  AA +G  EV R 
Sbjct: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356

Query: 485 LVQDGAQVEAKAKD-DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
           L+  GA +   + +  ++ L ++   G  D+V+ LL+ GA     T   +T L  +  +G
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416

Query: 544 HEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLH 603
           H +VA  LLD GA +++      +PL +AA  G +E+A LL+++ A+ +     G TPL 
Sbjct: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476

Query: 604 VAAHYDNQKVALLLLDQGASPHAAAKNGY-TPLHIAAKKNQMDIATTLLEYGADANAVTR 662
            AA   ++++  LLL QGA+ +A  +    T L +A      ++A  L++ GAD      
Sbjct: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536

Query: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAH 722
             +     A+QEGH+++V  LL   ANV+ +  +G T L  A +    +VA+VL+  GA 
Sbjct: 537 TPLME---ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593

Query: 723 VDAQTKM 729
           +D Q  M
Sbjct: 594 LDKQEDM 600



 Score =  171 bits (433), Expect = 1e-41
 Identities = 144/462 (31%), Positives = 216/462 (46%), Gaps = 18/462 (3%)

Query: 360 VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELL 419
           VD  T   L AL  AA  G    A    D KA  + + L   T   ++C  +        
Sbjct: 138 VDPETQARLEALLEAAGIGKLSTA----DGKAFADPEVLRRLTS-SVSCALDEAAAALTR 192

Query: 420 LKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQA 479
           +K   S  A  +     +  A   G VN V +L+  G S N     GE+ L +A  +G  
Sbjct: 193 MKAENSHNA-GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYY 251

Query: 480 EVVRYLVQDGAQVEAKA-KDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHL 538
           E+ + L+   A VE +  K D TPL  ++  G  DIV+ LL   A  N+ + +G T L  
Sbjct: 252 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 311

Query: 539 SAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAG--- 595
           +   G  D+   LL+ GA++    + G TPL  AA  G +EVA +LL   A  +      
Sbjct: 312 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371

Query: 596 -KSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 654
            +S LT      H D   +   LL+ GA         +T L  A     +++A  LL+ G
Sbjct: 372 KESALTLACYKGHLD---MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428

Query: 655 ADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAE 714
           A  N       + + LAA  GHV++ +LL+ R AN+   N  G TPL  AA+E    +  
Sbjct: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488

Query: 715 VLVNQGAHVDAQTKMGY-TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQ 773
           +L+ QGA+++AQT+    T L + C  G  ++ +FL++  A +        TPL +A+Q+
Sbjct: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQE 545

Query: 774 GHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
           GH  ++  LL + A+ +  T  G+TAL  A   G+  V D L
Sbjct: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587



 Score =  171 bits (432), Expect = 2e-41
 Identities = 133/426 (31%), Positives = 208/426 (48%), Gaps = 7/426 (1%)

Query: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFT-PLHIACKKNRIKVMELLLKHGA 424
           + L  L  +  C   + A  L   KA  +  A    T  L  AC    +  +  LL  G 
Sbjct: 170 EVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR 229

Query: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSG-QAEVVR 483
           S+   TE G + + +A   G+  +   L+   A+      +G+    MAA SG   ++V+
Sbjct: 230 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 289

Query: 484 YLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
            L+   A V +++    T L  +   G  DIV+ LL +GA+      +G+TPL  +A  G
Sbjct: 290 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 349

Query: 544 HEDVAAFLLDHGASLSITTKK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPL 602
           H +VA  LLDHGA ++  + +   + L +A   G L++   LL+  A  +       T L
Sbjct: 350 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409

Query: 603 HVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTR 662
             A    + +VA LLLD GA  +  A +  +PL +AA    +++A  L+E GA+   V  
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469

Query: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNL-SNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721
           +G   +  AA+EGH +MV+LLL + AN+N  + ++  T L LA       VA+ L+  GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529

Query: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781
            ++       TPL      G++++V +LL   A V+A T  G T L  A + GHT + +V
Sbjct: 530 DIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 586

Query: 782 LLQNNA 787
           LLQ  A
Sbjct: 587 LLQAGA 592



 Score =  164 bits (415), Expect = 2e-39
 Identities = 119/391 (30%), Positives = 195/391 (49%), Gaps = 6/391 (1%)

Query: 370 ALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429
           +L  A   G     + LLD+  + N     G + L +AC     ++ ++LL   A+++  
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 430 TESG-LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488
              G +TP+  A+  G+++IV  L+ H A  N+ +  G TAL  A   G  ++V+ L+ +
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS-GYTPLHLSAREGHEDV 547
           GA +E   ++  TPL  +A  G  ++ + LL  GA  N  +     + L L+  +GH D+
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387

Query: 548 AAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAH 607
             FLL+ GA     T +  T L  A   G +EVA LLL   A  +    S  +PL +AA 
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447

Query: 608 YDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI-A 666
             + ++A LL+++GA+       GYTPL  AA++   ++   LL  GA+ NA T +    
Sbjct: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 507

Query: 667 SVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQ 726
           ++ LA   G  ++   L+   A++ L      TPL  A+QE  + + + L+  GA+V A 
Sbjct: 508 ALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHAT 564

Query: 727 TKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757
           T  G T L   C  G+  + + LLQ  A ++
Sbjct: 565 TATGDTALTYACENGHTDVADVLLQAGADLD 595



 Score =  155 bits (391), Expect = 1e-36
 Identities = 128/403 (31%), Positives = 198/403 (49%), Gaps = 19/403 (4%)

Query: 2   AHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYL-RAARAGHLEKALDY 60
           +H A Q+      E  ++ +    RK     R   + ++   S L  A  AG+ E A   
Sbjct: 198 SHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVL 257

Query: 61  IKNGVDI-NICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ 119
           +    ++ +  N+  +  L  AS  G++++V  LL  +A+V++ +  GNTAL  A   G 
Sbjct: 258 LAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317

Query: 120 AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLA 178
            ++VKVL+  GAN+   ++NG TPL  AA   H+EV + LLD+GA   + + E   + L 
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377

Query: 179 VALQQGHDQVVSLLLENDTKGKVRLPALHIAARK----DDTKAAALLLQNDNNADVESKS 234
           +A  +GH  +V  LLE     + +   +H A  +       + A LLL +    ++ + S
Sbjct: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437

Query: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294
             +PL +AA  G++ +A LL+ R A ++       TPL  A++ G+  MV LLL +GA I
Sbjct: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497

Query: 295 DAKTRD----GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS-PLHMATQGDHLNC 349
           +A+T +     LT   CG   G  +V + L+   A I    + G S PL  A+Q  HL  
Sbjct: 498 NAQTEETQETALTLACCG---GFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLEL 550

Query: 350 VQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
           V+ LL     V   T    TAL  A   GH  VA VLL   A+
Sbjct: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593



 Score =  123 bits (309), Expect = 4e-27
 Identities = 89/283 (31%), Positives = 143/283 (50%), Gaps = 32/283 (11%)

Query: 46  LRAARAGHLEKALDYIKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAAT 104
           + AA AGH+E A   + +G  IN   N+   +AL LA  +GH+++V  LL+  A+ +  T
Sbjct: 343 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKT 402

Query: 105 KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
            + +TAL  A + G  EV ++L+ +GA VN  + +  +PL +AA   H+E+   L++ GA
Sbjct: 403 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 462

Query: 165 SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN 224
           +     ++G+TPL  A ++GH+++V+LLL             +I A+ ++T+  AL L  
Sbjct: 463 NLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQETALTL-- 511

Query: 225 DNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMV 284
                            A   G   VA  L+   A ++       TPL  AS+ G+  +V
Sbjct: 512 -----------------ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELV 551

Query: 285 KLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327
           K LL  GA + A T  G T L     +GH  V ++LL   A +
Sbjct: 552 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594



 Score = 50.8 bits (120), Expect = 3e-05
 Identities = 37/93 (39%), Positives = 50/93 (53%), Gaps = 6/93 (6%)

Query: 46  LRAARAGHLEKALDY-IKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAA 103
           L  A  G   +  D+ IK G DI + C+      L  AS+EGH+E+V  LL   ANV A 
Sbjct: 509 LTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHAT 564

Query: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
           T  G+TAL  A   G  +V  VL+  GA+++ Q
Sbjct: 565 TATGDTALTYACENGHTDVADVLLQAGADLDKQ 597


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  185 bits (469), Expect = 1e-45
 Identities = 132/395 (33%), Positives = 200/395 (50%), Gaps = 12/395 (3%)

Query: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327
           D   L  A   G+ N V+ LLD G  ++  T +G + L     +G+ ++ ++LL   A +
Sbjct: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 253

Query: 328 LSKTKNG-LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
             +   G ++PL  A+ G +L+ V+LLL H+  V+  +    TAL  A   G   + KVL
Sbjct: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313

Query: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT----ESGLTPIHVAAF 442
           L++ AN      NG TPL  A     ++V  +LL HGA I   +    ES LT   +A +
Sbjct: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACY 370

Query: 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502
            GH+++V  L+  GA          TAL  A   G  EV R L+  GAQV   A   ++P
Sbjct: 371 KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 430

Query: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562
           L ++A  G  ++   L+++GA+       GYTPL  +AREGHE++ A LL  GA+++  T
Sbjct: 431 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 490

Query: 563 KK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621
           ++   T L +A   G  EVA+ L++  A  +       TPL  A+   + ++   LL  G
Sbjct: 491 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 547

Query: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD 656
           A+ HA    G T L  A +    D+A  LL+ GAD
Sbjct: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGAD 582



 Score =  181 bits (459), Expect = 1e-44
 Identities = 136/427 (31%), Positives = 216/427 (50%), Gaps = 19/427 (4%)

Query: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGD-----------HLNCVQLLLQHNVPVDDVTN 365
           V   LD AA  L++ K   S  H A Q D            +N V+ LL     V++ T 
Sbjct: 168 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 225

Query: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG-FTPLHIACKKNRIKVMELLLKHGA 424
           +  + L +A   G+Y++A+VLL   AN   +   G  TPL  A     + +++LLL H A
Sbjct: 226 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 285

Query: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
            + + + +G T +  A   G V+IV  L++ GA+    N  G T L  AA +G  EV R 
Sbjct: 286 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 345

Query: 485 LVQDGAQVEAKAKD-DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
           L+  GA +   + +  ++ L ++   G  D+V+ LL+ GA     T   +T L  +  +G
Sbjct: 346 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 405

Query: 544 HEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLH 603
           H +VA  LLD GA +++      +PL +AA  G +E+A LL+++ A+ +     G TPL 
Sbjct: 406 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 465

Query: 604 VAAHYDNQKVALLLLDQGASPHAAAKNGY-TPLHIAAKKNQMDIATTLLEYGADANAVTR 662
            AA   ++++  LLL QGA+ +A  +    T L +A      ++A  L++ GAD      
Sbjct: 466 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 525

Query: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAH 722
             +     A+QEGH+++V  LL   ANV+ +  +G T L  A +    +VA+VL+  GA 
Sbjct: 526 TPLME---ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 582

Query: 723 VDAQTKM 729
           +D Q  M
Sbjct: 583 LDKQEDM 589



 Score =  171 bits (432), Expect = 2e-41
 Identities = 133/426 (31%), Positives = 208/426 (48%), Gaps = 7/426 (1%)

Query: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFT-PLHIACKKNRIKVMELLLKHGA 424
           + L  L  +  C   + A  L   KA  +  A    T  L  AC    +  +  LL  G 
Sbjct: 159 EVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR 218

Query: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSG-QAEVVR 483
           S+   TE G + + +A   G+  +   L+   A+      +G+    MAA SG   ++V+
Sbjct: 219 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 278

Query: 484 YLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
            L+   A V +++    T L  +   G  DIV+ LL +GA+      +G+TPL  +A  G
Sbjct: 279 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 338

Query: 544 HEDVAAFLLDHGASLSITTKK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPL 602
           H +VA  LLDHGA ++  + +   + L +A   G L++   LL+  A  +       T L
Sbjct: 339 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 398

Query: 603 HVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTR 662
             A    + +VA LLLD GA  +  A +  +PL +AA    +++A  L+E GA+   V  
Sbjct: 399 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 458

Query: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNL-SNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721
           +G   +  AA+EGH +MV+LLL + AN+N  + ++  T L LA       VA+ L+  GA
Sbjct: 459 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 518

Query: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781
            ++       TPL      G++++V +LL   A V+A T  G T L  A + GHT + +V
Sbjct: 519 DIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 575

Query: 782 LLQNNA 787
           LLQ  A
Sbjct: 576 LLQAGA 581



 Score =  170 bits (431), Expect = 2e-41
 Identities = 124/378 (32%), Positives = 188/378 (49%), Gaps = 12/378 (3%)

Query: 444 GHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA-KDDQTP 502
           G VN V +L+  G S N     GE+ L +A  +G  E+ + L+   A VE +  K D TP
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264

Query: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562
           L  ++  G  DIV+ LL   A  N+ + +G T L  +   G  D+   LL+ GA++    
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324

Query: 563 KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAG----KSGLTPLHVAAHYDNQKVALLLL 618
           + G TPL  AA  G +EVA +LL   A  +       +S LT      H D   +   LL
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD---MVRFLL 381

Query: 619 DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVD 678
           + GA         +T L  A     +++A  LL+ GA  N       + + LAA  GHV+
Sbjct: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441

Query: 679 MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY-TPLHVG 737
           + +LL+ R AN+   N  G TPL  AA+E    +  +L+ QGA+++AQT+    T L + 
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501

Query: 738 CHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN 797
           C  G  ++ +FL++  A +        TPL +A+Q+GH  ++  LL + A+ +  T  G+
Sbjct: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558

Query: 798 TALGIARRLGYISVVDTL 815
           TAL  A   G+  V D L
Sbjct: 559 TALTYACENGHTDVADVL 576



 Score =  164 bits (415), Expect = 2e-39
 Identities = 119/391 (30%), Positives = 195/391 (49%), Gaps = 6/391 (1%)

Query: 370 ALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429
           +L  A   G     + LLD+  + N     G + L +AC     ++ ++LL   A+++  
Sbjct: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256

Query: 430 TESG-LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488
              G +TP+  A+  G+++IV  L+ H A  N+ +  G TAL  A   G  ++V+ L+ +
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316

Query: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS-GYTPLHLSAREGHEDV 547
           GA +E   ++  TPL  +A  G  ++ + LL  GA  N  +     + L L+  +GH D+
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376

Query: 548 AAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAH 607
             FLL+ GA     T +  T L  A   G +EVA LLL   A  +    S  +PL +AA 
Sbjct: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436

Query: 608 YDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI-A 666
             + ++A LL+++GA+       GYTPL  AA++   ++   LL  GA+ NA T +    
Sbjct: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496

Query: 667 SVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQ 726
           ++ LA   G  ++   L+   A++ L      TPL  A+QE  + + + L+  GA+V A 
Sbjct: 497 ALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHAT 553

Query: 727 TKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757
           T  G T L   C  G+  + + LLQ  A ++
Sbjct: 554 TATGDTALTYACENGHTDVADVLLQAGADLD 584



 Score =  155 bits (391), Expect = 1e-36
 Identities = 128/403 (31%), Positives = 198/403 (49%), Gaps = 19/403 (4%)

Query: 2   AHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYL-RAARAGHLEKALDY 60
           +H A Q+      E  ++ +    RK     R   + ++   S L  A  AG+ E A   
Sbjct: 187 SHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVL 246

Query: 61  IKNGVDI-NICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ 119
           +    ++ +  N+  +  L  AS  G++++V  LL  +A+V++ +  GNTAL  A   G 
Sbjct: 247 LAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 306

Query: 120 AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLA 178
            ++VKVL+  GAN+   ++NG TPL  AA   H+EV + LLD+GA   + + E   + L 
Sbjct: 307 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 366

Query: 179 VALQQGHDQVVSLLLENDTKGKVRLPALHIAARK----DDTKAAALLLQNDNNADVESKS 234
           +A  +GH  +V  LLE     + +   +H A  +       + A LLL +    ++ + S
Sbjct: 367 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 426

Query: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294
             +PL +AA  G++ +A LL+ R A ++       TPL  A++ G+  MV LLL +GA I
Sbjct: 427 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 486

Query: 295 DAKTRD----GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS-PLHMATQGDHLNC 349
           +A+T +     LT   CG   G  +V + L+   A I    + G S PL  A+Q  HL  
Sbjct: 487 NAQTEETQETALTLACCG---GFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLEL 539

Query: 350 VQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
           V+ LL     V   T    TAL  A   GH  VA VLL   A+
Sbjct: 540 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 582



 Score =  123 bits (309), Expect = 4e-27
 Identities = 89/283 (31%), Positives = 143/283 (50%), Gaps = 32/283 (11%)

Query: 46  LRAARAGHLEKALDYIKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAAT 104
           + AA AGH+E A   + +G  IN   N+   +AL LA  +GH+++V  LL+  A+ +  T
Sbjct: 332 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKT 391

Query: 105 KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
            + +TAL  A + G  EV ++L+ +GA VN  + +  +PL +AA   H+E+   L++ GA
Sbjct: 392 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 451

Query: 165 SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN 224
           +     ++G+TPL  A ++GH+++V+LLL             +I A+ ++T+  AL L  
Sbjct: 452 NLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQETALTL-- 500

Query: 225 DNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMV 284
                            A   G   VA  L+   A ++       TPL  AS+ G+  +V
Sbjct: 501 -----------------ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELV 540

Query: 285 KLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327
           K LL  GA + A T  G T L     +GH  V ++LL   A +
Sbjct: 541 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583



 Score = 50.8 bits (120), Expect = 3e-05
 Identities = 37/93 (39%), Positives = 50/93 (53%), Gaps = 6/93 (6%)

Query: 46  LRAARAGHLEKALDY-IKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAA 103
           L  A  G   +  D+ IK G DI + C+      L  AS+EGH+E+V  LL   ANV A 
Sbjct: 498 LTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHAT 553

Query: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
           T  G+TAL  A   G  +V  VL+  GA+++ Q
Sbjct: 554 TATGDTALTYACENGHTDVADVLLQAGADLDKQ 586


>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
          Length = 1119

 Score =  178 bits (452), Expect = 9e-44
 Identities = 141/514 (27%), Positives = 243/514 (47%), Gaps = 39/514 (7%)

Query: 305 LHCGARSGHEQVVEMLL-DRAAPILSKTKN-GLSPLHMATQGDHLNCVQLLLQHNVPVDD 362
           LH  A  G  +++E +  D +  +L +  + G +PLH A + + +  V+ LL      + 
Sbjct: 67  LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126

Query: 363 VTNDYLTALHVAAHCGHYKVAKVLLDKKA-NPNAKALNGFTPLHIACKKNRIKVMELLLK 421
              + +  LH+A    + +V KVLL+ +  + N +  NG T + IAC  N  + +++LLK
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186

Query: 422 HGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH----HGASP----NTTNVRGETALHMA 473
            GA      + G  PIH AAF G    +  ++     HG S     N  N    T LH+A
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246

Query: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ--GASPNAATTS 531
            ++G  E+++  + +GAQ++   K   T +H +A  G  +IV+ ++    G+     TT 
Sbjct: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306

Query: 532 GY--TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA 589
           G   T LH ++   H ++A +L+  GA ++    +G +PL +A       + NLLL K A
Sbjct: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366

Query: 590 SPDAAGKSGLTPLHVAAHY------------DNQKVALLLLDQGASPHAAAKNGYTPLHI 637
             D     G   LH+                  Q++  L++D+         +G TPLH 
Sbjct: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDED-------NDGCTPLHY 419

Query: 638 AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS- 696
           A ++        LL +    ++ ++   + +H AA  G ++    LL   ++  L N+  
Sbjct: 420 ACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD 479

Query: 697 --GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSA 754
             G+TPLHLAA+     V ++L+ +GA +      G+T LH     G  + +  +L  + 
Sbjct: 480 LHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNL 538

Query: 755 KVNAKT-KNGYTPLHQAAQQGHTHIINVLLQNNA 787
           K   +  ++G T LH AA++GH   + +LL +NA
Sbjct: 539 KCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572



 Score =  177 bits (450), Expect = 2e-43
 Identities = 138/505 (27%), Positives = 231/505 (45%), Gaps = 24/505 (4%)

Query: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLD-RGAK 293
           G TPLH A     I     LL+R A  +    N + PLH+A +  N  ++K+LL+ R   
Sbjct: 98  GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTID 157

Query: 294 IDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLL 353
           ++ +  +G T +     + + + +++LL + A      K G  P+H A       C++++
Sbjct: 158 VNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEII 217

Query: 354 LQ--------HNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLH 405
           L+          + ++ + N   T LH+A   G  ++ K+ LD  A  +       T +H
Sbjct: 218 LRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIH 277

Query: 406 IACKKNRIKVMELLLK-HGASIQAV-TESGL--TPIHVAAFMGHVNIVSQLMHHGASPNT 461
            A  +   ++++L++  +  S+  V T  G   T +H A+   H  +   L+  GA  N 
Sbjct: 278 FAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINK 337

Query: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR--LGKADIVQQLL 519
            +  G + L +A  S    +V  L+  GAQV+ K    +  LH++ +   G  ++  + +
Sbjct: 338 IDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFM 397

Query: 520 QQGASPNAAT---TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYG 576
           Q              G TPLH + R+G       LL    S+   +K   +PLH AA YG
Sbjct: 398 QMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 457

Query: 577 KLEVANLLLQKSASPDAAGKS---GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYT 633
           ++     LLQ  +      +    G+TPLH+AA   + KV  LLL +GA    +  NG+T
Sbjct: 458 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGAL-FLSDHNGWT 516

Query: 634 PLHIAAKKNQMDIATTLLEYGADA-NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNL 692
            LH A+          +L+      + +   G  ++H AA+EGH   V+LLL  NA++ L
Sbjct: 517 ALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVL 576

Query: 693 SNKSGLTPLHLAAQEDRVNVAEVLV 717
            NK   + LHLA    R  V   ++
Sbjct: 577 -NKQQASFLHLALHNKRKEVVLTII 600



 Score =  174 bits (442), Expect = 1e-42
 Identities = 143/538 (26%), Positives = 257/538 (47%), Gaps = 34/538 (6%)

Query: 111 LHIASLAGQAEVVKVLVTNGAN--VNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSL 168
           LH A+  GQ E+++ +  + +   ++     G TPL+ A ++N +E VKFLL  GA+ +L
Sbjct: 67  LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126

Query: 169 ATEDGFTPLAVALQQGHDQVVSLLLENDT-----KGKVRLPALHIAARKDDTKAAALLLQ 223
              +   PL +A+Q  +++V+ +LLE+ T     +G+    A+ IA   ++++A  +LL+
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186

Query: 224 NDNNADVESKSGFTPLHIAAHYGNINVATLLL--------NRAAAVDFTARNDITPLHVA 275
                   +K G  P+H AA  G+     ++L        +R   ++F      TPLH+A
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246

Query: 276 SKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLD--RAAPILSKTKN 333
            + G+  M+K+ LD GA+ID   +   T +H  A  G  ++V++++     +  +  T +
Sbjct: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306

Query: 334 GL--SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
           G   + LH A+  DH      L+     ++ + ++  + L +A     + +  +LL K A
Sbjct: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGA 366

Query: 392 NPNAKALNGFTPLHIACK-----KNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHV 446
             + K   G   LH+  +     KN       + +    +      G TP+H A   G  
Sbjct: 367 QVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGP 426

Query: 447 NIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD---QTPL 503
             V+ L+    S ++ +   ++ LH AA  G+    + L+QD +      + D    TPL
Sbjct: 427 GSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPL 486

Query: 504 HISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK 563
           H++A+ G   +VQ LL++GA    +  +G+T LH ++  G+      +LD   +L  T +
Sbjct: 487 HLAAKNGHDKVVQLLLKKGAL-FLSDHNGWTALHHASMGGYTQTMKVILD--TNLKCTDR 543

Query: 564 ---KGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618
               G T LH AA+ G  +   LLL  +A      K   + LH+A H   ++V L ++
Sbjct: 544 LDEDGNTALHFAAREGHAKAVALLLSHNAD-IVLNKQQASFLHLALHNKRKEVVLTII 600



 Score =  174 bits (441), Expect = 2e-42
 Identities = 149/547 (27%), Positives = 253/547 (46%), Gaps = 34/547 (6%)

Query: 70  CNQNGLNALHLASKEGHVEVVSELLQREANVDAATKK---GNTALHIASLAGQAEVVKVL 126
           C+      LH A+ EG +E++ E + R+++++   +    GNT LH A    Q E VK L
Sbjct: 59  CDDMDTFFLHYAAAEGQIELM-EKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFL 117

Query: 127 VTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA-SQSLATEDGFTPLAVALQQGH 185
           ++ GAN N ++ N   PL++A Q  + EV+K LL++     +L  E+G T + +A    +
Sbjct: 118 LSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNN 177

Query: 186 DQVVSLLLENDTK----GKVRLPALHIAARKDDTKAAALLLQ--------NDNNADVESK 233
            + + +LL+   K     K     +H AA     +   ++L+           + +  + 
Sbjct: 178 SEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNN 237

Query: 234 SGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLD--RG 291
              TPLH+A   G++ +  + L+  A +D   +   T +H A+ +G   +VKL++    G
Sbjct: 238 GKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSG 297

Query: 292 AKIDAKTRDGL--TPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNC 349
           +     T DG   T LH  +   H ++ + L+   A I      G SPL +AT     N 
Sbjct: 298 SVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNI 357

Query: 350 VQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKAL------NGFTP 403
           V LLL     VD   N     LH+      Y +  +  +       K L      +G TP
Sbjct: 358 VNLLLSKGAQVDIKDNFGRNFLHLTVQ-QPYGLKNLRPEFMQMQQIKELVMDEDNDGCTP 416

Query: 404 LHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP---N 460
           LH AC++     +  LL    SI + ++   +P+H AA  G +N   +L+   +     N
Sbjct: 417 LHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLN 476

Query: 461 TTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ 520
             ++ G T LH+AA++G  +VV+ L++ GA +     +  T LH ++  G    ++ +L 
Sbjct: 477 EGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILD 535

Query: 521 QGAS-PNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLE 579
                 +     G T LH +AREGH    A LL H A + +  K+  + LH+A    + E
Sbjct: 536 TNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKE 594

Query: 580 VANLLLQ 586
           V   +++
Sbjct: 595 VVLTIIR 601



 Score =  152 bits (383), Expect = 9e-36
 Identities = 129/480 (26%), Positives = 221/480 (46%), Gaps = 27/480 (5%)

Query: 360 VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELL 419
           V D T D+  +L V      Y +      KK       ++ F  LH A  + +I++ME +
Sbjct: 25  VPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLK-RCDDMDTFF-LHYAAAEGQIELMEKI 82

Query: 420 LKHGAS--IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSG 477
            +  +   +  + + G TP+H A     +  V  L+  GA+PN  N      LH+A +  
Sbjct: 83  TRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGM 142

Query: 478 QAEVVRYLVQDGA-QVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPL 536
             EV++ L++     V  + ++  T + I+     ++ +Q LL++GA P  +   G  P+
Sbjct: 143 NNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPI 202

Query: 537 HLSAREGHEDVAAFLL----DHGAS----LSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588
           H +A  G ++    +L    +HG S    ++       TPLH+A + G LE+  + L   
Sbjct: 203 HQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNG 262

Query: 589 ASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ--GASPHAAAKNGY--TPLHIAAKKNQM 644
           A  D   K   T +H AA     ++  L++    G+       +G   T LH A+  +  
Sbjct: 263 AQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHH 322

Query: 645 DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLA 704
           ++A  L+  GAD N +  +G + + LA      ++V+LLL + A V++ +  G   LHL 
Sbjct: 323 ELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLT 382

Query: 705 AQED------RVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758
            Q+       R    ++   +   +D +   G TPLH  C  G    VN LL  +  +++
Sbjct: 383 VQQPYGLKNLRPEFMQMQQIKELVMD-EDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHS 441

Query: 759 KTKNGYTPLHQAAQQGHTHIINVLLQNNASP---NELTVNGNTALGIARRLGYISVVDTL 815
           K+K+  +PLH AA  G  +    LLQ+ +     NE  ++G T L +A + G+  VV  L
Sbjct: 442 KSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLL 501



 Score =  142 bits (359), Expect = 6e-33
 Identities = 126/450 (28%), Positives = 209/450 (46%), Gaps = 31/450 (6%)

Query: 65  VDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVK 124
           +D+N+  +NG  A+ +A    + E +  LL++ A    + K G   +H A+ +G  E ++
Sbjct: 156 IDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECME 215

Query: 125 VLVTNG--------ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTP 176
           +++  G         ++N  +    TPL++A Q   LE++K  LDNGA      +   T 
Sbjct: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTA 275

Query: 177 LAVALQQGHDQVVSLLLEN--------DTKGKVRLPALHIAARKDDTKAAALLLQNDNNA 228
           +  A  QG  ++V L++ +        +T        LH A+  D  + A  L+    + 
Sbjct: 276 IHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADI 335

Query: 229 DVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKR--GNANM--- 283
           +     G +PL +A    + N+  LLL++ A VD         LH+  ++  G  N+   
Sbjct: 336 NKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPE 395

Query: 284 -VKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMAT 342
            +++   +   +D +  DG TPLH   R G    V  LL     I SK+K+  SPLH A 
Sbjct: 396 FMQMQQIKELVMD-EDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAA 454

Query: 343 QGDHLNCVQLLLQHNVPVDDVTND----YLTALHVAAHCGHYKVAKVLLDKKANPNAKAL 398
               +N  Q LLQ ++    + N+     +T LH+AA  GH KV ++LL KK        
Sbjct: 455 SYGRINTCQRLLQ-DISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLL-KKGALFLSDH 512

Query: 399 NGFTPLHIACKKNRIKVMELLLKHGAS-IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 457
           NG+T LH A      + M+++L         + E G T +H AA  GH   V+ L+ H A
Sbjct: 513 NGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNA 572

Query: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQ 487
                N +  + LH+A  + + EVV  +++
Sbjct: 573 D-IVLNKQQASFLHLALHNKRKEVVLTIIR 601



 Score =  127 bits (319), Expect = 2e-28
 Identities = 103/363 (28%), Positives = 164/363 (45%), Gaps = 25/363 (6%)

Query: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR-EANVDAA-TK 105
           A + G LE     + NG  I+   +    A+H A+ +G  E+V  ++     +VD   T 
Sbjct: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305

Query: 106 KG--NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163
            G   T LH ASL    E+   L++ GA++N     G +PL +A       +V  LL  G
Sbjct: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365

Query: 164 ASQSLATEDGFTPLAVALQQGH------------DQVVSLLLENDTKGKVRLPALHIAAR 211
           A   +    G   L + +QQ +             Q+  L+++ D  G      LH A R
Sbjct: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDG---CTPLHYACR 422

Query: 212 KDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDI-- 269
           +    +   LL  + +   +SK   +PLH AA YG IN    LL   +        D+  
Sbjct: 423 QGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHG 482

Query: 270 -TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
            TPLH+A+K G+  +V+LLL +GA +     +G T LH  +  G+ Q ++++LD      
Sbjct: 483 MTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCT 541

Query: 329 SK-TKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLL 387
            +  ++G + LH A +  H   V LLL HN  +  +     + LH+A H    +V   ++
Sbjct: 542 DRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNKRKEVVLTII 600

Query: 388 DKK 390
             K
Sbjct: 601 RSK 603



 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 52/166 (31%), Positives = 87/166 (52%), Gaps = 6/166 (3%)

Query: 31  RSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVV 90
           +S+D+K      ASY    R    ++ L  I +   +N  + +G+  LHLA+K GH +VV
Sbjct: 442 KSKDKKSPLHFAASY---GRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVV 498

Query: 91  SELLQREANVDAATKKGNTALHIASLAGQAEVVKVLV-TNGANVNAQSQNGFTPLYMAAQ 149
             LL++ A +  +   G TALH AS+ G  + +KV++ TN    +   ++G T L+ AA+
Sbjct: 499 QLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAR 557

Query: 150 ENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195
           E H + V  LL + A   L  +   + L +AL     +VV  ++ +
Sbjct: 558 EGHAKAVALLLSHNADIVLNKQQA-SFLHLALHNKRKEVVLTIIRS 602


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  177 bits (450), Expect = 2e-43
 Identities = 119/402 (29%), Positives = 200/402 (49%), Gaps = 3/402 (0%)

Query: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAH 376
           ++ LL++   +  + + G +PL +A +  +L  V+ L+++    +    D  TAL  A+ 
Sbjct: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80

Query: 377 CGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTP 436
            GH  + + LL    N   + + G+T L  AC K R  V+ELLL HGA+        + P
Sbjct: 81  EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP 140

Query: 437 IHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA 496
           I  AA  GH +IV  L+ +GA  N ++  G T L  AAR G  E V++L+  GA V+ + 
Sbjct: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200

Query: 497 KDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGA 556
            +  T L ++ + G    V+++L++  + N     G T L ++++EGH ++   LLD G 
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260

Query: 557 SLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALL 616
            ++I  + G T L  A + G +E+   LLQK A  D  G+   T L+ A    N  +   
Sbjct: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320

Query: 617 LLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGH 676
           +L          K+G TPL  A K   +++   LL+ GA  +AV ++G   +H+A +   
Sbjct: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380

Query: 677 VDMVSLLLGRNANVNL---SNKSGLTPLHLAAQEDRVNVAEV 715
             +  LLL    +  L    NK+G TP ++     +  + ++
Sbjct: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQI 422



 Score =  175 bits (444), Expect = 8e-43
 Identities = 114/377 (30%), Positives = 187/377 (49%)

Query: 409 KKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468
           ++  I  ++ LL+    +    E G TP+ +AA  G++ IV +L+ +GA+ N  ++   T
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73

Query: 469 ALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAA 528
           AL  A++ G   +V  L++ G  +E +     T L  +   G+ D+V+ LL  GA+P+  
Sbjct: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133

Query: 529 TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588
                 P+  +A  GH D+   LL +GA ++ + K G TPL  AA+ G LE    LL   
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193

Query: 589 ASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIAT 648
           A  D  G + +T L VA      +    +L +  + +   K+G T L IA+K+   +I  
Sbjct: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253

Query: 649 TLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQED 708
            LL+ G   N   R G   +  A + GHV++V  LL + A++++  +   T L+ A ++ 
Sbjct: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313

Query: 709 RVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLH 768
              +   ++      +  TK G TPL       NI++V  LL   AKV+A  K G TPLH
Sbjct: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373

Query: 769 QAAQQGHTHIINVLLQN 785
            A +     +  +LL+N
Sbjct: 374 IAIRGRSRKLAELLLRN 390



 Score =  172 bits (437), Expect = 5e-42
 Identities = 119/362 (32%), Positives = 179/362 (49%), Gaps = 4/362 (1%)

Query: 83  KEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFT 142
           +E ++  +  LL++  +VD   + G T L IA+  G  E+VK L+ NGAN N +  + +T
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73

Query: 143 PLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTK 198
            L  A++E H+ +V+ LL  G +       G+T L  A  +G   VV LLL +       
Sbjct: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133

Query: 199 GKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRA 258
           G   +  +  AA +       LLLQN    +   K G TPL  AA  G++     LL   
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193

Query: 259 AAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVE 318
           A VD    N +T L VA K G    VK +L R   ++   +DG T L   ++ GH ++V+
Sbjct: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253

Query: 319 MLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCG 378
            LLD    +    ++G + L  A +G H+  V+ LLQ    +D    D  TAL+ A   G
Sbjct: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313

Query: 379 HYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIH 438
           +  + + +L    +      +G TPL  A K   I+V+ELLL  GA + AV + G TP+H
Sbjct: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373

Query: 439 VA 440
           +A
Sbjct: 374 IA 375



 Score =  164 bits (414), Expect = 2e-39
 Identities = 116/383 (30%), Positives = 180/383 (46%)

Query: 280 NANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLH 339
           N   +K LL++   +D +   G TPL   A  G+ ++V+ L+   A    +  +  + L 
Sbjct: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76

Query: 340 MATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALN 399
            A++  H++ V+ LL+  V ++       TAL  A + G   V ++LL   ANP+   L 
Sbjct: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136

Query: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459
              P+  A  +    ++ LLL++GA +    + G TP+  AA  GH+  V  L+  GA  
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196

Query: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519
           +       TAL +A + G  + V+ +++    V    KD  T L I+++ G  +IVQ LL
Sbjct: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256

Query: 520 QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLE 579
             G   N    SG T L  + R GH ++   LL   A + I  +   T L+ A + G   
Sbjct: 257 DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT 316

Query: 580 VANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639
           +   +LQ +   +   K G TPL  A    N +V  LLLD+GA   A  K G TPLHIA 
Sbjct: 317 MVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAI 376

Query: 640 KKNQMDIATTLLEYGADANAVTR 662
           +     +A  LL    D   + R
Sbjct: 377 RGRSRKLAELLLRNPKDGRLLYR 399



 Score =  164 bits (414), Expect = 2e-39
 Identities = 119/411 (28%), Positives = 198/411 (48%), Gaps = 3/411 (0%)

Query: 384 KVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFM 443
           K LL+K  + + +   G TPL IA ++  +++++ L+K+GA+         T +  A+  
Sbjct: 22  KALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE 81

Query: 444 GHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPL 503
           GHV+IV +L+  G +    ++ G TAL  A   G+ +VV  L+  GA           P+
Sbjct: 82  GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141

Query: 504 HISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK 563
             +A  G ADIV  LLQ GA  N +   G TPL  +AR+GH +    LL  GA +     
Sbjct: 142 IWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201

Query: 564 KGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGAS 623
              T L VA K G  +    +L+++ + +   K G T L +A+   + ++   LLD G  
Sbjct: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261

Query: 624 PHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLL 683
            +   ++G T L  A +   ++I   LL+  AD +   +    +++ A ++G+  MV  +
Sbjct: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321

Query: 684 LGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNI 743
           L  N +  +  K G TPL  A +   + V E+L+++GA V A  K G TPLH+     + 
Sbjct: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381

Query: 744 KIVNFLLQH---SAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791
           K+   LL++      +    K G TP +       + +  +    + SP E
Sbjct: 382 KLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTE 432



 Score =  162 bits (409), Expect = 9e-39
 Identities = 120/375 (32%), Positives = 188/375 (50%), Gaps = 13/375 (3%)

Query: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
           AA  G+LE   + IKNG + N+ + +   AL  ASKEGHV +V ELL+   N++     G
Sbjct: 45  AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104

Query: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
            TAL  A   G+ +VV++L+++GAN +        P+  AA   H ++V  LL NGA  +
Sbjct: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164

Query: 168 LATEDGFTPLAVALQQGHDQVVSLLL----ENDTKGKVRLPALHIAARKDDTKAAALLLQ 223
            + + G TPL  A ++GH + V  LL    + D +G   + AL +A +   T++   +L+
Sbjct: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224

Query: 224 NDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANM 283
            + N ++  K G T L IA+  G+  +   LL+    V+   R+  T L  A + G+  +
Sbjct: 225 RNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEI 284

Query: 284 VKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQ 343
           V+ LL + A ID + +D  T L+     G+  +V  +L         TK+G +PL  AT+
Sbjct: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344

Query: 344 GDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKAL----- 398
             ++  V+LLL     V  V     T LH+A      K+A++LL    NP    L     
Sbjct: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLL---RNPKDGRLLYRPN 401

Query: 399 -NGFTPLHIACKKNR 412
             G TP +I C   +
Sbjct: 402 KAGETPYNIDCSHQK 416



 Score =  160 bits (404), Expect = 3e-38
 Identities = 123/446 (27%), Positives = 197/446 (44%), Gaps = 32/446 (7%)

Query: 149 QENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHI 208
           +E ++  +K LL+         E G TPL +A +QG+ ++V  L++N             
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGA----------- 62

Query: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
                             N ++E    +T L  A+  G++++   LL     ++      
Sbjct: 63  ------------------NCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104

Query: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
            T L  A  +G  ++V+LLL  GA         + P+   A  GH  +V +LL   A + 
Sbjct: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164

Query: 329 SKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLD 388
              K G +PL  A +  HL CV+ LL     VD    + +TAL VA   G+ +  K +L 
Sbjct: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224

Query: 389 KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448
           +  N N    +G T L IA K+   ++++ LL  G  +     SG T +  A   GHV I
Sbjct: 225 RNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEI 284

Query: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508
           V  L+   A  +      +TAL+ A   G A +VR ++Q     E   KD +TPL  + +
Sbjct: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344

Query: 509 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH---GASLSITTKKG 565
           +   ++V+ LL +GA  +A    G TPLH++ R     +A  LL +   G  L    K G
Sbjct: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAG 404

Query: 566 FTPLHVAAKYGKLEVANLLLQKSASP 591
            TP ++   + K  +  +   +  SP
Sbjct: 405 ETPYNIDCSHQKSILTQIFGARHLSP 430



 Score =  159 bits (403), Expect = 4e-38
 Identities = 102/334 (30%), Positives = 174/334 (52%)

Query: 482 VRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAR 541
           ++ L++    V+ + +  QTPL I+A  G  +IV++L++ GA+ N      +T L  +++
Sbjct: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80

Query: 542 EGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTP 601
           EGH  +   LL  G +L      G+T L  A   G+ +V  LLL   A+P   G   + P
Sbjct: 81  EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP 140

Query: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
           +  AA   +  +  LLL  GA  + + K G TPL  AA+K  ++    LL  GAD +   
Sbjct: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200

Query: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721
              + ++ +A + G+   V  +L RN NVNL++K G T L +A++E    + + L++ G 
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260

Query: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781
           +V+   + G T L      G+++IV  LLQ  A ++ + ++  T L+ A ++G+  ++  
Sbjct: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320

Query: 782 LLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
           +LQ N      T +G T L  A ++  I VV+ L
Sbjct: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354



 Score =  155 bits (391), Expect = 1e-36
 Identities = 103/343 (30%), Positives = 168/343 (48%)

Query: 463 NVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG 522
           N  G+T L +AA  G  E+V+ L+++GA    +  D+ T L  +++ G   IV++LL+ G
Sbjct: 35  NECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCG 94

Query: 523 ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVAN 582
            +       G+T L  +  +G  DV   LL HGA+ S+T      P+  AA  G  ++ +
Sbjct: 95  VNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVH 154

Query: 583 LLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN 642
           LLLQ  A  + + K G TPL  AA   + +    LL  GA       N  T L +A K  
Sbjct: 155 LLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGG 214

Query: 643 QMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLH 702
                  +L+   + N   + G  ++ +A++EGH ++V  LL     VN+ ++SG T L 
Sbjct: 215 YTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLI 274

Query: 703 LAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKN 762
            A +   V +   L+ + A +D + +   T L+     GN  +V  +LQ +      TK+
Sbjct: 275 GAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKD 334

Query: 763 GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARR 805
           G TPL +A +  +  ++ +LL   A  + +   G+T L IA R
Sbjct: 335 GETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIR 377



 Score =  147 bits (370), Expect = 3e-34
 Identities = 100/315 (31%), Positives = 162/315 (51%), Gaps = 4/315 (1%)

Query: 46  LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK 105
           + A++ GH+    + +K GV++   +  G  AL  A  +G  +VV  LL   AN      
Sbjct: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135

Query: 106 KGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS 165
                +  A+  G A++V +L+ NGA VN   + G TPL  AA++ HLE VK LL  GA 
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195

Query: 166 QSLATEDGFTPLAVALQQGHDQVVSLLLENDTK----GKVRLPALHIAARKDDTKAAALL 221
                 +  T L VA++ G+ Q V  +L+ +       K    AL IA+++  T+    L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255

Query: 222 LQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNA 281
           L      ++  +SG T L  A   G++ +   LL + A +D   +++ T L+ A ++GNA
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315

Query: 282 NMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMA 341
            MV+ +L      +  T+DG TPL    +  + +VVE+LLD+ A + +  K G +PLH+A
Sbjct: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375

Query: 342 TQGDHLNCVQLLLQH 356
            +G      +LLL++
Sbjct: 376 IRGRSRKLAELLLRN 390



 Score = 93.2 bits (230), Expect = 5e-18
 Identities = 54/162 (33%), Positives = 90/162 (55%)

Query: 40  DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 99
           D N + + A++ GH E   D +  G  +NI +++G   L  A + GHVE+V  LLQ+ A+
Sbjct: 235 DGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYAD 294

Query: 100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159
           +D   +   TAL+ A   G A +V+ ++    +    +++G TPL  A +  ++EVV+ L
Sbjct: 295 IDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354

Query: 160 LDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKV 201
           LD GA  S   + G TPL +A++    ++  LLL N   G++
Sbjct: 355 LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRL 396



 Score = 59.7 bits (143), Expect = 6e-08
 Identities = 46/176 (26%), Positives = 74/176 (42%), Gaps = 33/176 (18%)

Query: 673 QEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQ-------------------------- 706
           +E ++  +  LL +  +V+  N+ G TPL +AA+                          
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73

Query: 707 -------EDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAK 759
                  E  V++ E L+  G +++ +   G+T L   C+ G   +V  LL H A  +  
Sbjct: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133

Query: 760 TKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
                 P+  AA +GH  I+++LLQN A  N     G T L  A R G++  V  L
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHL 189


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score =  166 bits (420), Expect = 5e-40
 Identities = 121/327 (37%), Positives = 168/327 (51%), Gaps = 13/327 (3%)

Query: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
           A + G   +V+QL+  GAS    +  G T LH+A   G A +VR L+Q GA V A  +  
Sbjct: 48  AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107

Query: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHG---- 555
           +T LH +A  G + + + LLQ+GAS  A + +G TPLH +A  GH  +AA LL+      
Sbjct: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGP 167

Query: 556 ASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLT-PLHVAAHYDNQKVA 614
           A+      +G+T  H AA  G+L V  LL        AAG +GL   L VAA        
Sbjct: 168 AAAEAEDARGWTAAHWAAAGGRLAVLELL--------AAGGAGLDGALLVAAAAGRGAAL 219

Query: 615 LLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQE 674
             LL +GA   A    G T L +AA   +      LL +GAD     R G +++H AA  
Sbjct: 220 RFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAAR 279

Query: 675 GHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPL 734
           GH+  V LL+ + A V+  +  GLTPLH A++E  V VA  L+++GA VDA   +  TPL
Sbjct: 280 GHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPL 339

Query: 735 HVGCHYGNIKIVNFLLQHSAKVNAKTK 761
           H+    G+   V  LL   A    +T+
Sbjct: 340 HLAAERGHGPTVGLLLSRGASPTLRTQ 366



 Score =  164 bits (414), Expect = 2e-39
 Identities = 117/330 (35%), Positives = 163/330 (49%), Gaps = 11/330 (3%)

Query: 464 VRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA 523
           V+G   L  A   G A +V  L++ GA VE +    +TPLH++   G A +V+ LLQ+GA
Sbjct: 39  VQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGA 98

Query: 524 SPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANL 583
              A   +G T LH +A  GH  VA  LL  GAS +  +  G TPLH AA  G   +A  
Sbjct: 99  PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAAR 158

Query: 584 LLQKSASPDAAGKS----GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639
           LL+      AA ++    G T  H AA      V  LL   GA    A       L +AA
Sbjct: 159 LLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAA 211

Query: 640 KKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLT 699
              +      LL  GA  +A    G  ++ LAA  G    + +LLG  A+  + ++ G +
Sbjct: 212 AAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS 271

Query: 700 PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAK 759
            LH AA    +   ++LV QGA VDA+  +G TPLH     G++++   LL   A+V+A 
Sbjct: 272 ALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDAT 331

Query: 760 TKNGYTPLHQAAQQGHTHIINVLLQNNASP 789
                TPLH AA++GH   + +LL   ASP
Sbjct: 332 GWLRKTPLHLAAERGHGPTVGLLLSRGASP 361



 Score =  162 bits (411), Expect = 5e-39
 Identities = 117/335 (34%), Positives = 163/335 (48%), Gaps = 15/335 (4%)

Query: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294
           G+  L  A   G   + T LL + A+V+       TPLH+A  RG+A +V+LLL RGA +
Sbjct: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100

Query: 295 DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLL 354
            A  R G T LH  A  GH +V E+LL R A   +++  GL+PLH A    H      LL
Sbjct: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160

Query: 355 QHNVP------VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIAC 408
           +   P       +D      TA H AA  G   V ++L           L+G   L +A 
Sbjct: 161 EAPGPGPAAAEAEDARG--WTAAHWAAAGGRLAVLELLA-----AGGAGLDG--ALLVAA 211

Query: 409 KKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468
              R   +  LL  GA + A   +G T + +AA +G    +  L+ HGA P   +  G +
Sbjct: 212 AAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS 271

Query: 469 ALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAA 528
           ALH AA  G    V+ LV  GA+V+A+     TPLH ++R G  ++   LL +GA  +A 
Sbjct: 272 ALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDAT 331

Query: 529 TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK 563
                TPLHL+A  GH      LL  GAS ++ T+
Sbjct: 332 GWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366



 Score =  152 bits (385), Expect = 5e-36
 Identities = 117/341 (34%), Positives = 160/341 (46%), Gaps = 32/341 (9%)

Query: 85  GHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPL 144
           G   +V++LL++ A+V+     G T LH+A L G A +V++L+  GA V A  + G T L
Sbjct: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111

Query: 145 YMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLP 204
           + AA   H  V + LL  GAS +  +  G TPL  A   GH  + + LLE    G    P
Sbjct: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPG----P 167

Query: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
           A                      A+ E   G+T  H AA  G + V  LL    A +D  
Sbjct: 168 AA---------------------AEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD-- 204

Query: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
                  L VA+  G    ++ LL RGA++DA+   G T L   A  G  Q +E+LL   
Sbjct: 205 -----GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHG 259

Query: 325 APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAK 384
           A    + ++G S LH A    HL  VQLL+     VD      LT LH A+  GH +VA 
Sbjct: 260 ADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAG 319

Query: 385 VLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGAS 425
            LLD+ A  +A      TPLH+A ++     + LLL  GAS
Sbjct: 320 CLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360



 Score =  145 bits (365), Expect = 1e-33
 Identities = 102/305 (33%), Positives = 147/305 (48%), Gaps = 30/305 (9%)

Query: 350 VQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACK 409
           V  LL+    V++  +   T LH+A   GH  + ++LL + A   A    G T LH A  
Sbjct: 57  VTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAW 116

Query: 410 KNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG----ASPNTTNVR 465
               +V ELLL+ GAS  A + +GLTP+H AA +GH  + ++L+       A+    + R
Sbjct: 117 HGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDAR 176

Query: 466 GETALHMAARSGQAEVV--------------------------RYLVQDGAQVEAKAKDD 499
           G TA H AA  G+  V+                          R+L+  GA+V+A+    
Sbjct: 177 GWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAG 236

Query: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559
            T L ++A LG++  ++ LL  GA P      G + LH +A  GH      L+  GA + 
Sbjct: 237 ATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVD 296

Query: 560 ITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619
                G TPLH A++ G +EVA  LL + A  DA G    TPLH+AA   +     LLL 
Sbjct: 297 ARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLS 356

Query: 620 QGASP 624
           +GASP
Sbjct: 357 RGASP 361



 Score =  135 bits (339), Expect = 1e-30
 Identities = 105/313 (33%), Positives = 145/313 (46%), Gaps = 7/313 (2%)

Query: 46  LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK 105
           L+A   G        ++ G  +   +  G   LHLA   GH  +V  LLQR A V A  +
Sbjct: 46  LQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDR 105

Query: 106 KGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS 165
            G TALH A+  G + V ++L+  GA+  A+S  G TPL+ AA   H  +   LL+    
Sbjct: 106 AGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGP 165

Query: 166 QSLATE----DGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALL 221
              A E     G+T    A   G   V+ LL      G     AL +AA      A   L
Sbjct: 166 GPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAG---GAGLDGALLVAAAAGRGAALRFL 222

Query: 222 LQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNA 281
           L      D    +G T L +AA  G      +LL   A      R+  + LH A+ RG+ 
Sbjct: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282

Query: 282 NMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMA 341
             V+LL+ +GA++DA+   GLTPLH  +R GH +V   LLDR A + +      +PLH+A
Sbjct: 283 LAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLA 342

Query: 342 TQGDHLNCVQLLL 354
            +  H   V LLL
Sbjct: 343 AERGHGPTVGLLL 355



 Score =  134 bits (338), Expect = 2e-30
 Identities = 112/360 (31%), Positives = 152/360 (42%), Gaps = 48/360 (13%)

Query: 118 GQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPL 177
           G A +V  L+  GA+V  +   G TPL++A    H  +V+ LL  GA        G T L
Sbjct: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111

Query: 178 AVALQQGHDQVVSLLLENDTKGKVR----LPALHIAARKDDTKAAALLLQNDNN----AD 229
             A   GH +V  LLL+       R    L  LH AA    T  AA LL+        A+
Sbjct: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAE 171

Query: 230 VESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLD 289
            E   G+T  H AA  G + V  LL    A +D         L VA+  G    ++ LL 
Sbjct: 172 AEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRFLLA 224

Query: 290 RGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNC 349
           RGA++DA+   G T L   A  G  Q +E+LL   A    + ++G S             
Sbjct: 225 RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRS------------- 271

Query: 350 VQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACK 409
                               ALH AA  GH    ++L+ + A  +A+   G TPLH A +
Sbjct: 272 --------------------ALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASR 311

Query: 410 KNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETA 469
           +  ++V   LL  GA + A      TP+H+AA  GH   V  L+  GASP       E A
Sbjct: 312 EGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVA 371



 Score =  124 bits (312), Expect = 2e-27
 Identities = 99/318 (31%), Positives = 140/318 (44%), Gaps = 30/318 (9%)

Query: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587
           +   G+  L  +   G   +   LL  GAS+      G TPLH+A   G   +  LLLQ+
Sbjct: 37  SVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQR 96

Query: 588 SASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIA 647
            A   A  ++G T LH AA + + +VA LLL +GAS  A +  G TPLH AA      +A
Sbjct: 97  GAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLA 156

Query: 648 TTLLEY----GADANAVTRQGIASVHLAAQEGHVDMVSL--------------------- 682
             LLE      A A A   +G  + H AA  G + ++ L                     
Sbjct: 157 ARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRG 216

Query: 683 -----LLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG 737
                LL R A V+  + +G T L LAA   R    EVL+  GA    + + G + LH  
Sbjct: 217 AALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRA 276

Query: 738 CHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN 797
              G++  V  L+   A+V+A+   G TPLH A+++GH  +   LL   A  +       
Sbjct: 277 AARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRK 336

Query: 798 TALGIARRLGYISVVDTL 815
           T L +A   G+   V  L
Sbjct: 337 TPLHLAAERGHGPTVGLL 354



 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 57/179 (31%), Positives = 84/179 (46%)

Query: 42  NASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVD 101
           + + L AA AG        +  G  ++  +  G  AL LA+  G  + +  LL   A+  
Sbjct: 204 DGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPG 263

Query: 102 AATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD 161
              + G +ALH A+  G    V++LVT GA V+A+   G TPL+ A++E H+EV   LLD
Sbjct: 264 IRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLD 323

Query: 162 NGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAAL 220
            GA          TPL +A ++GH   V LLL       +R     +A   +     AL
Sbjct: 324 RGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQAL 382


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.126    0.348 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 170,828,609
Number of Sequences: 37866
Number of extensions: 8446853
Number of successful extensions: 63072
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 400
Number of HSP's successfully gapped in prelim test: 814
Number of HSP's that attempted gapping in prelim test: 32276
Number of HSP's gapped (non-prelim): 17838
length of query: 4377
length of database: 18,247,518
effective HSP length: 123
effective length of query: 4254
effective length of database: 13,590,000
effective search space: 57811860000
effective search space used: 57811860000
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 73 (32.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.