Guide to the Human Genome
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Search of human proteins with 32967514

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]
         (507 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]                  990   0.0  
gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens]                  990   0.0  
gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]                  970   0.0  
gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens]                  969   0.0  
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]                  921   0.0  
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]                  921   0.0  
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]                  921   0.0  
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]                   898   0.0  
gi|4506467 radixin [Homo sapiens]                                     384   e-106
gi|161702986 ezrin [Homo sapiens]                                     376   e-104
gi|21614499 ezrin [Homo sapiens]                                      376   e-104
gi|4505257 moesin [Homo sapiens]                                      376   e-104
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...   114   2e-25
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...   114   2e-25
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...   114   2e-25
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...   112   8e-25
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho...   105   1e-22
gi|150010540 FERM domain containing 4B [Homo sapiens]                 102   6e-22
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi...   100   5e-21
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis...   100   5e-21
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i...    97   3e-20
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i...    97   3e-20
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i...    94   2e-19
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i...    94   2e-19
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi...    94   3e-19
gi|116063562 FERM domain containing 4A [Homo sapiens]                  92   1e-18
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform...    91   2e-18
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform...    91   2e-18
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s...    90   6e-18
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor...    89   7e-18

>gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]
          Length = 507

 Score =  990 bits (2559), Expect = 0.0
 Identities = 507/507 (100%), Positives = 507/507 (100%)

Query: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLAS 60
           MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLAS
Sbjct: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLAS 60

Query: 61  YAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEA 120
           YAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEA
Sbjct: 61  YAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEA 120

Query: 121 EMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRN 180
           EMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRN
Sbjct: 121 EMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRN 180

Query: 181 ISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKA 240
           ISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKA
Sbjct: 181 ISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKA 240

Query: 241 QAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADL 300
           QAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADL
Sbjct: 241 QAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADL 300

Query: 301 LAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE 360
           LAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE
Sbjct: 301 LAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE 360

Query: 361 SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGD 420
           SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGD
Sbjct: 361 SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGD 420

Query: 421 SLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHN 480
           SLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHN
Sbjct: 421 SLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHN 480

Query: 481 ENSDRGGSSKHNTIKKPQAQGRRPICI 507
           ENSDRGGSSKHNTIKKPQAQGRRPICI
Sbjct: 481 ENSDRGGSSKHNTIKKPQAQGRRPICI 507


>gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens]
          Length = 507

 Score =  990 bits (2559), Expect = 0.0
 Identities = 507/507 (100%), Positives = 507/507 (100%)

Query: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLAS 60
           MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLAS
Sbjct: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLAS 60

Query: 61  YAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEA 120
           YAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEA
Sbjct: 61  YAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEA 120

Query: 121 EMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRN 180
           EMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRN
Sbjct: 121 EMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRN 180

Query: 181 ISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKA 240
           ISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKA
Sbjct: 181 ISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKA 240

Query: 241 QAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADL 300
           QAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADL
Sbjct: 241 QAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADL 300

Query: 301 LAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE 360
           LAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE
Sbjct: 301 LAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE 360

Query: 361 SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGD 420
           SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGD
Sbjct: 361 SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGD 420

Query: 421 SLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHN 480
           SLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHN
Sbjct: 421 SLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHN 480

Query: 481 ENSDRGGSSKHNTIKKPQAQGRRPICI 507
           ENSDRGGSSKHNTIKKPQAQGRRPICI
Sbjct: 481 ENSDRGGSSKHNTIKKPQAQGRRPICI 507


>gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]
          Length = 548

 Score =  970 bits (2507), Expect = 0.0
 Identities = 507/548 (92%), Positives = 507/548 (92%), Gaps = 41/548 (7%)

Query: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEV--------------------- 39
           MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEV                     
Sbjct: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVLDHDVSKEEPVTFHFLAKFYP 60

Query: 40  --------------------KKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF 79
                               KKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF
Sbjct: 61  ENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF 120

Query: 80  LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF 139
           LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF
Sbjct: 121 LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF 180

Query: 140 AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV 199
           AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV
Sbjct: 181 AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV 240

Query: 200 FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE 259
           FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE
Sbjct: 241 FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE 300

Query: 260 KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA 319
           KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA
Sbjct: 301 KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA 360

Query: 320 AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR 379
           AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR
Sbjct: 361 AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR 420

Query: 380 EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE 439
           EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE
Sbjct: 421 EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE 480

Query: 440 KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA 499
           KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA
Sbjct: 481 KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA 540

Query: 500 QGRRPICI 507
           QGRRPICI
Sbjct: 541 QGRRPICI 548


>gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens]
          Length = 549

 Score =  969 bits (2506), Expect = 0.0
 Identities = 507/549 (92%), Positives = 507/549 (92%), Gaps = 42/549 (7%)

Query: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE---------------------- 38
           MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE                      
Sbjct: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60

Query: 39  --------------------VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRG 78
                               VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRG
Sbjct: 61  FFGLQYTIKDTVAWLKMDKKVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRG 120

Query: 79  FLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNY 138
           FLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNY
Sbjct: 121 FLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNY 180

Query: 139 FAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKID 198
           FAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKID
Sbjct: 181 FAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKID 240

Query: 199 VFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAR 258
           VFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAR
Sbjct: 241 VFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAR 300

Query: 259 EKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQK 318
           EKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQK
Sbjct: 301 EKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQK 360

Query: 319 AAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEA 378
           AAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEA
Sbjct: 361 AAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEA 420

Query: 379 REAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEI 438
           REAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEI
Sbjct: 421 REAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEI 480

Query: 439 EKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQ 498
           EKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQ
Sbjct: 481 EKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQ 540

Query: 499 AQGRRPICI 507
           AQGRRPICI
Sbjct: 541 AQGRRPICI 549


>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score =  921 bits (2380), Expect = 0.0
 Identities = 474/499 (94%), Positives = 481/499 (96%)

Query: 9   MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68
           ++F  L +  P+     +V    +  F  +VKKQILDEKIYCPPEASVLLASYAVQAKYG
Sbjct: 92  VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYG 151

Query: 69  DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128
           DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA
Sbjct: 152 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 211

Query: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188
           QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF
Sbjct: 212 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 271

Query: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248
           TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR
Sbjct: 272 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 331

Query: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308
           KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT
Sbjct: 332 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 391

Query: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 368
           EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA
Sbjct: 392 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 451

Query: 369 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 428
           DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD
Sbjct: 452 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 511

Query: 429 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 488
           TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS
Sbjct: 512 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 571

Query: 489 SKHNTIKKPQAQGRRPICI 507
           SKHNTIKKPQAQGRRPICI
Sbjct: 572 SKHNTIKKPQAQGRRPICI 590


>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score =  921 bits (2380), Expect = 0.0
 Identities = 474/499 (94%), Positives = 481/499 (96%)

Query: 9   MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68
           ++F  L +  P+     +V    +  F  +VKKQILDEKIYCPPEASVLLASYAVQAKYG
Sbjct: 92  VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYG 151

Query: 69  DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128
           DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA
Sbjct: 152 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 211

Query: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188
           QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF
Sbjct: 212 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 271

Query: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248
           TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR
Sbjct: 272 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 331

Query: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308
           KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT
Sbjct: 332 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 391

Query: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 368
           EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA
Sbjct: 392 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 451

Query: 369 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 428
           DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD
Sbjct: 452 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 511

Query: 429 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 488
           TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS
Sbjct: 512 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 571

Query: 489 SKHNTIKKPQAQGRRPICI 507
           SKHNTIKKPQAQGRRPICI
Sbjct: 572 SKHNTIKKPQAQGRRPICI 590


>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score =  921 bits (2380), Expect = 0.0
 Identities = 474/499 (94%), Positives = 481/499 (96%)

Query: 9   MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68
           ++F  L +  P+     +V    +  F  +VKKQILDEKIYCPPEASVLLASYAVQAKYG
Sbjct: 92  VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYG 151

Query: 69  DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128
           DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA
Sbjct: 152 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 211

Query: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188
           QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF
Sbjct: 212 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 271

Query: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248
           TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR
Sbjct: 272 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 331

Query: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308
           KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT
Sbjct: 332 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 391

Query: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 368
           EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA
Sbjct: 392 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 451

Query: 369 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 428
           DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD
Sbjct: 452 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 511

Query: 429 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 488
           TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS
Sbjct: 512 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 571

Query: 489 SKHNTIKKPQAQGRRPICI 507
           SKHNTIKKPQAQGRRPICI
Sbjct: 572 SKHNTIKKPQAQGRRPICI 590


>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
          Length = 595

 Score =  898 bits (2320), Expect = 0.0
 Identities = 464/495 (93%), Positives = 472/495 (95%)

Query: 9   MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68
           ++F  L +  P+     +V    +  F  +VKKQILDEKIYCPPEASVLLASYAVQAKYG
Sbjct: 92  VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYG 151

Query: 69  DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128
           DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA
Sbjct: 152 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 211

Query: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188
           QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF
Sbjct: 212 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 271

Query: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248
           TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR
Sbjct: 272 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 331

Query: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308
           KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT
Sbjct: 332 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 391

Query: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 368
           EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA
Sbjct: 392 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 451

Query: 369 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 428
           DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD
Sbjct: 452 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 511

Query: 429 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 488
           TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS
Sbjct: 512 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 571

Query: 489 SKHNTIKKPQAQGRR 503
           SKHNTIKK   Q  +
Sbjct: 572 SKHNTIKKLTLQSAK 586


>gi|4506467 radixin [Homo sapiens]
          Length = 583

 Score =  384 bits (985), Expect = e-106
 Identities = 201/485 (41%), Positives = 312/485 (64%), Gaps = 10/485 (2%)

Query: 19  PKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRG 78
           P+  +  ++    +  F  +VK+ IL+++IYCPPE +VLLASYAVQAKYGDY+  +HK G
Sbjct: 86  PEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPG 145

Query: 79  FLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNY 138
           +LA + LLP+RV+  +++T E WEERI  W+ EHRG  R+++ MEYLKIAQDLEMYGVNY
Sbjct: 146 YLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNY 205

Query: 139 FAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKID 198
           F I+NKKGTEL LGVDALGL+IY+ +++LTPKI FPW+EIRNIS++DK+F IKP+DKK  
Sbjct: 206 FEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAP 265

Query: 199 VFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAR 258
            F F + +LR+NK IL LC+GNH+L+MRRRK D++EVQQMKAQAREEK +KQ+ER +L  
Sbjct: 266 DFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLEN 325

Query: 259 EKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQK 318
           EK+ RE AE+ ++ +ER   ++ E      E  +++++  +    KA   ++E K   ++
Sbjct: 326 EKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEE 385

Query: 319 AAEAEQEMQRIK----ATAIRTEEEKRLMEQKVLEAEVLALKMA---EESERRAKEADQL 371
           A   E+E +  +    A A +  ++ +  EQ   E      K+A   E  +++ +EA + 
Sbjct: 386 AERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEW 445

Query: 372 KQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDM 431
           +     A+E   + K++L  + + P  PP  P+  P   +    +      S +  +  +
Sbjct: 446 QHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGV 505

Query: 432 KRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKH 491
             ++   E+E+V   +K++ +++QL  L +E+   + + ++T  D+LH EN  + G  K+
Sbjct: 506 --MNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENV-KAGRDKY 562

Query: 492 NTIKK 496
            T+++
Sbjct: 563 KTLRQ 567



 Score = 29.6 bits (65), Expect = 6.8
 Identities = 14/33 (42%), Positives = 20/33 (60%), Gaps = 3/33 (9%)

Query: 19 PKTFTVRIVTMDAEMEFNCE---VKKQILDEKI 48
          PK   VR+ TMDAE+EF  +     KQ+ D+ +
Sbjct: 2  PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVV 34


>gi|161702986 ezrin [Homo sapiens]
          Length = 586

 Score =  376 bits (966), Expect = e-104
 Identities = 212/502 (42%), Positives = 318/502 (63%), Gaps = 21/502 (4%)

Query: 9   MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68
           + F    +  P+     ++    +  F  +VK+ IL ++IYCPPE +VLL SYAVQAK+G
Sbjct: 76  LQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFG 135

Query: 69  DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128
           DY+  VHK G+L+ E L+P+RV++ +++T + WE+RI  W+AEHRG  +D A +EYLKIA
Sbjct: 136 DYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIA 195

Query: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188
           QDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FPW+EIRNIS++DK+F
Sbjct: 196 QDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKF 255

Query: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248
            IKP+DKK   F F + +LR+NK ILQLC+GNH+L+MRRRK D++EVQQMKAQAREEK +
Sbjct: 256 VIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQ 315

Query: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308
           KQ+ERQ+L  EK+ RE  ER ++++ R   ++        E   ++E       ++A   
Sbjct: 316 KQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQL 375

Query: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVLALKMAEESERRA-- 365
           EEE K    +A E  + ++  +  A+R +EE +R    ++   E LA ++AE + + A  
Sbjct: 376 EEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALL 431

Query: 366 KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPPDI--PSFNLIGDSL 422
           +EA + K+D  E  E + RAK+   + + TK     +   P P PP +  P    + +SL
Sbjct: 432 EEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESL 489

Query: 423 SFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETA 474
             +  +       LS E       E++++   EK++ +Q QL  L +E+   + + + T 
Sbjct: 490 QDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTH 549

Query: 475 LDILHNENSDRGGSSKHNTIKK 496
            DI+HNEN  R G  K+ T+++
Sbjct: 550 NDIIHNENM-RQGRDKYKTLRQ 570



 Score = 29.6 bits (65), Expect = 6.8
 Identities = 14/33 (42%), Positives = 20/33 (60%), Gaps = 3/33 (9%)

Query: 19 PKTFTVRIVTMDAEMEFNCE---VKKQILDEKI 48
          PK   VR+ TMDAE+EF  +     KQ+ D+ +
Sbjct: 2  PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVV 34


>gi|21614499 ezrin [Homo sapiens]
          Length = 586

 Score =  376 bits (966), Expect = e-104
 Identities = 212/502 (42%), Positives = 318/502 (63%), Gaps = 21/502 (4%)

Query: 9   MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68
           + F    +  P+     ++    +  F  +VK+ IL ++IYCPPE +VLL SYAVQAK+G
Sbjct: 76  LQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFG 135

Query: 69  DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128
           DY+  VHK G+L+ E L+P+RV++ +++T + WE+RI  W+AEHRG  +D A +EYLKIA
Sbjct: 136 DYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIA 195

Query: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188
           QDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FPW+EIRNIS++DK+F
Sbjct: 196 QDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKF 255

Query: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248
            IKP+DKK   F F + +LR+NK ILQLC+GNH+L+MRRRK D++EVQQMKAQAREEK +
Sbjct: 256 VIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQ 315

Query: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308
           KQ+ERQ+L  EK+ RE  ER ++++ R   ++        E   ++E       ++A   
Sbjct: 316 KQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQL 375

Query: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVLALKMAEESERRA-- 365
           EEE K    +A E  + ++  +  A+R +EE +R    ++   E LA ++AE + + A  
Sbjct: 376 EEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALL 431

Query: 366 KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPPDI--PSFNLIGDSL 422
           +EA + K+D  E  E + RAK+   + + TK     +   P P PP +  P    + +SL
Sbjct: 432 EEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESL 489

Query: 423 SFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETA 474
             +  +       LS E       E++++   EK++ +Q QL  L +E+   + + + T 
Sbjct: 490 QDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTH 549

Query: 475 LDILHNENSDRGGSSKHNTIKK 496
            DI+HNEN  R G  K+ T+++
Sbjct: 550 NDIIHNENM-RQGRDKYKTLRQ 570



 Score = 29.6 bits (65), Expect = 6.8
 Identities = 14/33 (42%), Positives = 20/33 (60%), Gaps = 3/33 (9%)

Query: 19 PKTFTVRIVTMDAEMEFNCE---VKKQILDEKI 48
          PK   VR+ TMDAE+EF  +     KQ+ D+ +
Sbjct: 2  PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVV 34


>gi|4505257 moesin [Homo sapiens]
          Length = 577

 Score =  376 bits (966), Expect = e-104
 Identities = 210/497 (42%), Positives = 316/497 (63%), Gaps = 16/497 (3%)

Query: 7   SRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAK 66
           S + F    +  P+  +  ++    +  F  +VK+ IL++ IYCPPE +VLLASYAVQ+K
Sbjct: 74  SPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSK 133

Query: 67  YGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLK 126
           YGD++  VHK G+LA ++LLP+RV+  +++  + WEERI  W+ EHRG  R++A +EYLK
Sbjct: 134 YGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLK 193

Query: 127 IAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDK 186
           IAQDLEMYGVNYF+I+NKKG+EL LGVDALGL+IY+  +RLTPKI FPW+EIRNIS++DK
Sbjct: 194 IAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDK 253

Query: 187 EFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEK 246
           +F IKP+DKK   F F + +LR+NK IL LC+GNH+L+MRRRK D++EVQQMKAQAREEK
Sbjct: 254 KFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEK 313

Query: 247 ARKQMERQRLAREKQMREEAERTRDELER-------RLLQMKEEATMANEALMRSEETAD 299
            +KQMER  L  EK+ RE AE+ ++++ER       RL Q++E+   A + L      A 
Sbjct: 314 HQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKAQQELEEQTRRAL 373

Query: 300 LLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAE 359
            L ++ +  + EA+ LA++  EAE+  +   A    + ++K+  EQ  LE   L  ++++
Sbjct: 374 ELEQERKRAQSEAEKLAKERQEAEEAKE---ALLQASRDQKKTQEQLALEMAELTARISQ 430

Query: 360 ESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIG 419
               R K+  +  +  Q+A+  +   ++   E+ T  + P +   PA    D    N  G
Sbjct: 431 LEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAE-PAENEQDEQDEN--G 487

Query: 420 DSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILH 479
              S D +   M +     E+E+    EK++ +Q+ L  L +E+   + + ++TA D++H
Sbjct: 488 AEASADLRADAMAK--DRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTANDMIH 545

Query: 480 NENSDRGGSSKHNTIKK 496
            EN  R G  K+ T+++
Sbjct: 546 AENM-RLGRDKYKTLRQ 561



 Score = 33.5 bits (75), Expect = 0.47
 Identities = 35/158 (22%), Positives = 70/158 (44%), Gaps = 14/158 (8%)

Query: 232 SLEVQQMKAQ------AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEAT 285
           +LE+ ++ A+      AR++K  + +E Q+ A+   ++E+ E+TR EL+  +        
Sbjct: 418 ALEMAELTARISQLEMARQKKESEAVEWQQKAQ--MVQEDLEKTRAELKTAMSTPHVAEP 475

Query: 286 MANEALMRSEE----TADLLAEKA--QITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE 339
             NE   + E     +ADL A+      +EEE    A+K    ++ ++ + +      +E
Sbjct: 476 AENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDE 535

Query: 340 KRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQE 377
            +     ++ AE + L   +    R       KQ + E
Sbjct: 536 SKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDE 573



 Score = 32.3 bits (72), Expect = 1.0
 Identities = 15/33 (45%), Positives = 22/33 (66%), Gaps = 3/33 (9%)

Query: 19 PKTFTVRIVTMDAEMEFNCE---VKKQILDEKI 48
          PKT +VR+ TMDAE+EF  +     KQ+ D+ +
Sbjct: 2  PKTISVRVTTMDAELEFAIQPNTTGKQLFDQVV 34


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
           isoform 4 [Homo sapiens]
          Length = 2490

 Score =  114 bits (285), Expect = 2e-25
 Identities = 76/256 (29%), Positives = 130/256 (50%), Gaps = 9/256 (3%)

Query: 34  EFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINL 93
           ++  +++K IL+E+++C  E S+LLAS A+QA+YGDY P VH   +   E  LP RV+  
Sbjct: 678 QYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEK 737

Query: 94  YQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLL 151
             ++    +E +   +  + G +  E E+E+LK+ Q L  YGV++  +    K  T +LL
Sbjct: 738 LDLS--YIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILL 795

Query: 152 GVDALGLHIYDPENRL-TPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVN 210
           GV + G+ +++  N + T  + FPW E + IS+S K+ T++     I    F +   ++ 
Sbjct: 796 GVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKIC 854

Query: 211 KLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQR---LAREKQMREEAE 267
           + +L LC   H   ++ R   S +  Q   +A       Q E  R   + R       A 
Sbjct: 855 QYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLAS 914

Query: 268 RTRDELERRLLQMKEE 283
            T ++L  R L ++ E
Sbjct: 915 STLNKLAVRPLSVQAE 930


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
           isoform 1 [Homo sapiens]
          Length = 2485

 Score =  114 bits (285), Expect = 2e-25
 Identities = 76/256 (29%), Positives = 130/256 (50%), Gaps = 9/256 (3%)

Query: 34  EFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINL 93
           ++  +++K IL+E+++C  E S+LLAS A+QA+YGDY P VH   +   E  LP RV+  
Sbjct: 678 QYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEK 737

Query: 94  YQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLL 151
             ++    +E +   +  + G +  E E+E+LK+ Q L  YGV++  +    K  T +LL
Sbjct: 738 LDLS--YIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILL 795

Query: 152 GVDALGLHIYDPENRL-TPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVN 210
           GV + G+ +++  N + T  + FPW E + IS+S K+ T++     I    F +   ++ 
Sbjct: 796 GVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKIC 854

Query: 211 KLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQR---LAREKQMREEAE 267
           + +L LC   H   ++ R   S +  Q   +A       Q E  R   + R       A 
Sbjct: 855 QYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLAS 914

Query: 268 RTRDELERRLLQMKEE 283
            T ++L  R L ++ E
Sbjct: 915 STLNKLAVRPLSVQAE 930


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13
           isoform 2 [Homo sapiens]
          Length = 2466

 Score =  114 bits (285), Expect = 2e-25
 Identities = 76/256 (29%), Positives = 130/256 (50%), Gaps = 9/256 (3%)

Query: 34  EFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINL 93
           ++  +++K IL+E+++C  E S+LLAS A+QA+YGDY P VH   +   E  LP RV+  
Sbjct: 678 QYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEK 737

Query: 94  YQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLL 151
             ++    +E +   +  + G +  E E+E+LK+ Q L  YGV++  +    K  T +LL
Sbjct: 738 LDLS--YIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILL 795

Query: 152 GVDALGLHIYDPENRL-TPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVN 210
           GV + G+ +++  N + T  + FPW E + IS+S K+ T++     I    F +   ++ 
Sbjct: 796 GVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKIC 854

Query: 211 KLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQR---LAREKQMREEAE 267
           + +L LC   H   ++ R   S +  Q   +A       Q E  R   + R       A 
Sbjct: 855 QYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLAS 914

Query: 268 RTRDELERRLLQMKEE 283
            T ++L  R L ++ E
Sbjct: 915 STLNKLAVRPLSVQAE 930


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
           isoform 3 [Homo sapiens]
          Length = 2294

 Score =  112 bits (280), Expect = 8e-25
 Identities = 66/203 (32%), Positives = 114/203 (56%), Gaps = 8/203 (3%)

Query: 34  EFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINL 93
           ++  +++K IL+E+++C  E S+LLAS A+QA+YGDY P VH   +   E  LP RV+  
Sbjct: 678 QYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEK 737

Query: 94  YQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLL 151
             ++    +E +   +  + G +  E E+E+LK+ Q L  YGV++  +    K  T +LL
Sbjct: 738 LDLS--YIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILL 795

Query: 152 GVDALGLHIYDPENRL-TPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVN 210
           GV + G+ +++  N + T  + FPW E + IS+S K+ T++     I    F +   ++ 
Sbjct: 796 GVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKIC 854

Query: 211 KLILQLCIGNH--DLFMRRRKAD 231
           + +L LC   H   L MR R+++
Sbjct: 855 QYLLHLCSYQHKFQLQMRARQSN 877


>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
           sapiens]
          Length = 926

 Score =  105 bits (261), Expect = 1e-22
 Identities = 62/195 (31%), Positives = 106/195 (54%), Gaps = 15/195 (7%)

Query: 34  EFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINL 93
           ++  ++K+ IL  ++ CP   + LLAS+AVQ++ GDYD S +  G+L+    +P +    
Sbjct: 125 QYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQ---- 180

Query: 94  YQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGV 153
               P+ +E+ I   + +H G +  EAE  YL  A+ LE+YGV +   R++   E+++GV
Sbjct: 181 ----PQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGV 236

Query: 154 DALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTI---KPL-DKKIDVFKFNSSKLRV 209
            + G+ IY    R+    +FPW +I  IS+  K+F I   K L + +  +  FN    R 
Sbjct: 237 MSGGILIYKNRVRMN---TFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRA 293

Query: 210 NKLILQLCIGNHDLF 224
            K + + C+ +H  F
Sbjct: 294 CKNLWKACVEHHTFF 308


>gi|150010540 FERM domain containing 4B [Homo sapiens]
          Length = 1034

 Score =  102 bits (255), Expect = 6e-22
 Identities = 99/427 (23%), Positives = 197/427 (46%), Gaps = 55/427 (12%)

Query: 6   ASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQA 65
           A R    S+   + KT TV +  ++A+    C  K QI  E      E    LA++ +Q 
Sbjct: 137 AVRFYIESISFLKDKT-TVELFFLNAKA---CVHKGQIEVES-----ETIFKLAAFILQE 187

Query: 66  KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEM--WEERITAWYAEHRGRARDEAEME 123
             GDY    + R  L      P + +   Q  P +   E+R+   Y + +G  R +A ++
Sbjct: 188 AKGDYTSDENARKDLKTLPAFPTKTL---QEHPSLAYCEDRVIEHYLKIKGLTRGQAVVQ 244

Query: 124 YLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISY 183
           Y+KI + L  YGV+Y+A+++K+G    LG+   G+  YD ++++ P+  F W ++ N+ +
Sbjct: 245 YMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYF 304

Query: 184 SDKEFTIKPLD-KKIDVFK--FNSSKLRVN---------KLILQLCIGNHDLFMRRRKA- 230
            +K+F ++  D ++I V +  F  S L V          K I  + I  H  ++ R+++ 
Sbjct: 305 REKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQSK 364

Query: 231 ----DSLEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDELE 274
                +  + ++     E   ++  +   L  + Q              +++E + ++  
Sbjct: 365 AKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSEEQKR 424

Query: 275 RRLLQMKEEATMANEALMRS-EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATA 333
            ++L++K++  +  E L++  EE   +   +A++T +  K       E   +++R   TA
Sbjct: 425 EKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRRVGTA 484

Query: 334 IR-------TEEEKRLMEQKVLEAE-VLALKMAEESERRAKEADQLKQDLQEAREAERRA 385
            +       +EE+  L E   LE+  ++  K+ E +++ A E D  K   ++ ++    A
Sbjct: 485 FKLDDNLLPSEEDPALQE---LESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTDA 541

Query: 386 KQKLLEI 392
            +KL EI
Sbjct: 542 MKKLQEI 548


>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 1 [Homo sapiens]
          Length = 775

 Score = 99.8 bits (247), Expect = 5e-21
 Identities = 79/358 (22%), Positives = 157/358 (43%), Gaps = 18/358 (5%)

Query: 27  VTMDAEMEFNC-EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL 85
           +T D    + C ++++ I+  ++ C      LL SY +Q++ GDYDP +H   +++  +L
Sbjct: 261 LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKL 320

Query: 86  LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKK 145
            P +   L        EE++   +  +R     +A++E+L+ A+ L MYGV+    ++ +
Sbjct: 321 APNQTKEL--------EEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLE 372

Query: 146 GTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK---- 201
           G +++LGV + GL +Y  + R+     FPW ++  ISY    F IK    + + ++    
Sbjct: 373 GVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIG 429

Query: 202 FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQ 261
           F     R  K + ++C+  H  F R    D++   +  A   + +   + + Q       
Sbjct: 430 FKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASAL 488

Query: 262 MREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEA-KLLAQKAA 320
           +   A        +R  +  + A   + A      T+     + Q+ E       A+K  
Sbjct: 489 IDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTV 548

Query: 321 EAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEA 378
             + + + +KA   + +E     E +  EA     K  EE ++      +LK++  E+
Sbjct: 549 VPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMES 606


>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
           RH-linked) isoform 3 [Homo sapiens]
          Length = 588

 Score = 99.8 bits (247), Expect = 5e-21
 Identities = 82/391 (20%), Positives = 171/391 (43%), Gaps = 22/391 (5%)

Query: 27  VTMDAEMEFNC-EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL 85
           +T D    + C ++++ I+  ++ C      LL SY +Q++ GDYDP +H   +++  +L
Sbjct: 87  LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKL 146

Query: 86  LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKK 145
            P +   L        EE++   +  +R     +A++E+L+ A+ L MYGV+    ++ +
Sbjct: 147 APNQTKEL--------EEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLE 198

Query: 146 GTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK---- 201
           G +++LGV + GL +Y  + R+     FPW ++  ISY    F IK    + + ++    
Sbjct: 199 GVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIG 255

Query: 202 FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQ 261
           F     R  K + ++C+  H  F R    D++   +  A   + +   + + Q       
Sbjct: 256 FKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASAL 314

Query: 262 MREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEA-KLLAQKAA 320
           +   A        +R  +  + A   + A      T+     + Q+ E       A+K  
Sbjct: 315 IDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTV 374

Query: 321 EAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEARE 380
             + + + +KA   + +E     E +  EA     +  +      + ++ + +DL +++E
Sbjct: 375 VPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQE 434

Query: 381 AERRAKQKLLEIATKPTYPPMNPIPAPLPPD 411
             ++    + E+  K  +  M  +P P P +
Sbjct: 435 EIKKHHASISEL--KKNF--MESVPEPRPSE 461


>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
           isoform 2 [Homo sapiens]
          Length = 868

 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 54/195 (27%), Positives = 102/195 (52%), Gaps = 15/195 (7%)

Query: 38  EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 97
           ++K  I + ++ CP  ++V+LASYAVQ+ +GDY+ S+H  G+L+    +P +        
Sbjct: 129 QLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ-------- 180

Query: 98  PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 157
            E +  ++ + + +H G  + EAE  Y+ IA+ L+ YGV   + R+    +L++G+ + G
Sbjct: 181 NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAG 240

Query: 158 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTI----KPLDKKIDVFKFNSSKLRVNKLI 213
           + +Y    +      +PW  I  IS+  K+F I    K  + +  +  FN    R  K +
Sbjct: 241 VAVY---RKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNL 297

Query: 214 LQLCIGNHDLFMRRR 228
            + C+ +H  F  ++
Sbjct: 298 WKSCVEHHTFFQAKK 312


>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
           isoform 1 [Homo sapiens]
          Length = 913

 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 54/195 (27%), Positives = 102/195 (52%), Gaps = 15/195 (7%)

Query: 38  EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 97
           ++K  I + ++ CP  ++V+LASYAVQ+ +GDY+ S+H  G+L+    +P +        
Sbjct: 129 QLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ-------- 180

Query: 98  PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 157
            E +  ++ + + +H G  + EAE  Y+ IA+ L+ YGV   + R+    +L++G+ + G
Sbjct: 181 NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAG 240

Query: 158 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTI----KPLDKKIDVFKFNSSKLRVNKLI 213
           + +Y    +      +PW  I  IS+  K+F I    K  + +  +  FN    R  K +
Sbjct: 241 VAVY---RKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNL 297

Query: 214 LQLCIGNHDLFMRRR 228
            + C+ +H  F  ++
Sbjct: 298 WKSCVEHHTFFQAKK 312


>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
           isoform 4 [Homo sapiens]
          Length = 737

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 53/190 (27%), Positives = 99/190 (52%), Gaps = 15/190 (7%)

Query: 43  ILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWE 102
           I + ++ CP  ++V+LASYAVQ+ +GDY+ S+H  G+L+    +P +         E + 
Sbjct: 3   ICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ--------NEDFL 54

Query: 103 ERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYD 162
            ++ + + +H G  + EAE  Y+ IA+ L+ YGV   + R+    +L++G+ + G+ +Y 
Sbjct: 55  TKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVY- 113

Query: 163 PENRLTPKISFPWNEIRNISYSDKEFTI----KPLDKKIDVFKFNSSKLRVNKLILQLCI 218
              +      +PW  I  IS+  K+F I    K  + +  +  FN    R  K + + C+
Sbjct: 114 --RKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCV 171

Query: 219 GNHDLFMRRR 228
            +H  F  ++
Sbjct: 172 EHHTFFQAKK 181


>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
           isoform 3 [Homo sapiens]
          Length = 782

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 53/190 (27%), Positives = 99/190 (52%), Gaps = 15/190 (7%)

Query: 43  ILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWE 102
           I + ++ CP  ++V+LASYAVQ+ +GDY+ S+H  G+L+    +P +         E + 
Sbjct: 3   ICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ--------NEDFL 54

Query: 103 ERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYD 162
            ++ + + +H G  + EAE  Y+ IA+ L+ YGV   + R+    +L++G+ + G+ +Y 
Sbjct: 55  TKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVY- 113

Query: 163 PENRLTPKISFPWNEIRNISYSDKEFTI----KPLDKKIDVFKFNSSKLRVNKLILQLCI 218
              +      +PW  I  IS+  K+F I    K  + +  +  FN    R  K + + C+
Sbjct: 114 --RKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCV 171

Query: 219 GNHDLFMRRR 228
            +H  F  ++
Sbjct: 172 EHHTFFQAKK 181


>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 2 [Homo sapiens]
          Length = 641

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 73/330 (22%), Positives = 145/330 (43%), Gaps = 18/330 (5%)

Query: 27  VTMDAEMEFNC-EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL 85
           +T D    + C ++++ I+  ++ C      LL SY +Q++ GDYDP +H   +++  +L
Sbjct: 87  LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKL 146

Query: 86  LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKK 145
            P +   L        EE++   +  +R     +A++E+L+ A+ L MYGV+    ++ +
Sbjct: 147 APNQTKEL--------EEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLE 198

Query: 146 GTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK---- 201
           G +++LGV + GL +Y  + R+     FPW ++  ISY    F IK    + + ++    
Sbjct: 199 GVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIG 255

Query: 202 FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQ 261
           F     R  K + ++C+  H  F R    D++   +  A   + +   + + Q       
Sbjct: 256 FKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASAL 314

Query: 262 MREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEA-KLLAQKAA 320
           +   A        +R  +  + A   + A      T+     + Q+ E       A+K  
Sbjct: 315 IDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTV 374

Query: 321 EAEQEMQRIKATAIRTEEEKRLMEQKVLEA 350
             + + + +KA   + +E     E +  EA
Sbjct: 375 VPKAQKETVKAEVKKEDEPPEQAEPEPTEA 404


>gi|116063562 FERM domain containing 4A [Homo sapiens]
          Length = 1039

 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 87/394 (22%), Positives = 168/394 (42%), Gaps = 37/394 (9%)

Query: 35  FNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLY 94
           F    K  I  E I    E    LASY +Q   GD+  +   R  L +   LP + +  +
Sbjct: 118 FFLNAKSCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEH 177

Query: 95  QMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVD 154
                  E+R+   Y +  G+ R +A + Y+ I + L  YGV+Y+A+++K+G    LG+ 
Sbjct: 178 PSLAYC-EDRVIEHYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLS 236

Query: 155 ALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIK---PLDKKIDVFKFNSSKLRVN- 210
             G+  YD  +++ P+  F W ++ N+ + +K+F+++   P    +    F  S + V+ 
Sbjct: 237 YKGIFQYDYHDKVKPRKIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHT 296

Query: 211 --------KLILQLCIGNHDLFMRRRKADS-----LEVQQMKAQAREEKARKQMERQRLA 257
                   K I  + I  H  ++ R+++ S       + ++     E    K  +   + 
Sbjct: 297 WYACPALIKSIWAMAISQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMG 356

Query: 258 REKQM------------REEAERTRDELERRLLQMKEEATMANEAL-MRSEETADLLAEK 304
            + ++             +E++ ++   +  L  +K       E L  R EE   L   +
Sbjct: 357 SKGKIISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCLRE 416

Query: 305 AQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMA------ 358
           A++T +          E    ++R   TA + +E+K L + +  E E L  + A      
Sbjct: 417 AELTGKLPVEYPLDPGEEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQIT 476

Query: 359 EESERRAKEADQLKQDLQEAREAERRAKQKLLEI 392
           E + R A + +  K+  ++ + +   A +KL EI
Sbjct: 477 EAARRLASDPNVSKKLKKQRKTSYLNALKKLQEI 510


>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
           [Homo sapiens]
          Length = 779

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 63/203 (31%), Positives = 99/203 (48%), Gaps = 16/203 (7%)

Query: 27  VTMDAEMEFNC-EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL 85
           +T D    + C +++  I+  ++ C      LL SYAVQA+ GDYD   H   ++++   
Sbjct: 121 LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF 180

Query: 86  LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKK 145
            P +   L        EERI   +  +RG    EAE+ +L+ A+ L MYGV+    ++ +
Sbjct: 181 APNQTREL--------EERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSE 232

Query: 146 GTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK---- 201
           G +++LGV A GL IY    R+     F W +I  ISY    F IK    + + F+    
Sbjct: 233 GIDIMLGVCANGLLIYRDRLRIN---RFAWPKILKISYKRSNFYIKIRPGEYEQFESTIG 289

Query: 202 FNSSKLRVNKLILQLCIGNHDLF 224
           F     R  K + ++CI +H  F
Sbjct: 290 FKLPNHRSAKRLWKVCIEHHTFF 312


>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
           [Homo sapiens]
          Length = 881

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 63/203 (31%), Positives = 99/203 (48%), Gaps = 16/203 (7%)

Query: 27  VTMDAEMEFNC-EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL 85
           +T D    + C +++  I+  ++ C      LL SYAVQA+ GDYD   H   ++++   
Sbjct: 183 LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF 242

Query: 86  LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKK 145
            P +   L        EERI   +  +RG    EAE+ +L+ A+ L MYGV+    ++ +
Sbjct: 243 APNQTREL--------EERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSE 294

Query: 146 GTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK---- 201
           G +++LGV A GL IY    R+     F W +I  ISY    F IK    + + F+    
Sbjct: 295 GIDIMLGVCANGLLIYRDRLRIN---RFAWPKILKISYKRSNFYIKIRPGEYEQFESTIG 351

Query: 202 FNSSKLRVNKLILQLCIGNHDLF 224
           F     R  K + ++CI +H  F
Sbjct: 352 FKLPNHRSAKRLWKVCIEHHTFF 374


>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
           sapiens]
          Length = 1087

 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 56/191 (29%), Positives = 92/191 (48%), Gaps = 15/191 (7%)

Query: 38  EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 97
           +++  I+  ++ C      LL SY VQ++ GDYDP      ++++    P     L    
Sbjct: 208 QLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKEL---- 263

Query: 98  PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 157
               E+++   +  HRG    EAEM +L+ A+ L MYGV+    ++ +G E++LGV A G
Sbjct: 264 ----EDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASG 319

Query: 158 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLI 213
           L IY    R+     F W ++  ISY    F IK    + + F+    F     R  K +
Sbjct: 320 LLIYRDRLRIN---RFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRL 376

Query: 214 LQLCIGNHDLF 224
            ++C+ +H  F
Sbjct: 377 WKVCVEHHTFF 387


>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 59/203 (29%), Positives = 100/203 (49%), Gaps = 16/203 (7%)

Query: 27  VTMDAEMEFNC-EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL 85
           +T D    F C ++++ I   ++ C      LL SY +QA+ GDYDP  H    L++ + 
Sbjct: 304 LTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQF 363

Query: 86  LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKK 145
            P +   L        EE++   +  HRG +  +A+ ++L+ A+ L MYGV+    ++ +
Sbjct: 364 APTQTKEL--------EEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSE 415

Query: 146 GTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK---- 201
           G ++ LGV A GL IY    R+     F W +I  ISY    F IK    +++ F+    
Sbjct: 416 GVDIKLGVCANGLLIYKDRLRIN---RFAWPKILKISYKRSNFYIKVRPAELEQFESTIG 472

Query: 202 FNSSKLRVNKLILQLCIGNHDLF 224
           F     R  K + ++C+ +H  +
Sbjct: 473 FKLPNHRAAKRLWKVCVEHHTFY 495


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,475,290
Number of Sequences: 37866
Number of extensions: 806324
Number of successful extensions: 18292
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 611
Number of HSP's successfully gapped in prelim test: 1016
Number of HSP's that attempted gapping in prelim test: 6030
Number of HSP's gapped (non-prelim): 6628
length of query: 507
length of database: 18,247,518
effective HSP length: 107
effective length of query: 400
effective length of database: 14,195,856
effective search space: 5678342400
effective search space used: 5678342400
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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