Guide to the Human Genome
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Search of human proteins with 32967254

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
         (590 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]                 1163   0.0  
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]                 1163   0.0  
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]                 1163   0.0  
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]                  1140   0.0  
gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens]                 1060   0.0  
gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]                 1052   0.0  
gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]                  921   0.0  
gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens]                  921   0.0  
gi|4506467 radixin [Homo sapiens]                                     501   e-142
gi|4505257 moesin [Homo sapiens]                                      496   e-140
gi|161702986 ezrin [Homo sapiens]                                     489   e-138
gi|21614499 ezrin [Homo sapiens]                                      489   e-138
gi|32967268 neurofibromin 2 isoform 8 [Homo sapiens]                  303   2e-82
gi|150010540 FERM domain containing 4B [Homo sapiens]                 150   2e-36
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...   142   9e-34
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...   142   9e-34
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...   142   9e-34
gi|116063562 FERM domain containing 4A [Homo sapiens]                 142   1e-33
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...   140   3e-33
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform...   139   7e-33
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform...   139   7e-33
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho...   137   2e-32
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i...   135   1e-31
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i...   135   1e-31
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s...   134   2e-31
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis...   132   9e-31
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor...   128   1e-29
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor...   128   1e-29
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ...   128   1e-29
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi...   126   5e-29

>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score = 1163 bits (3008), Expect = 0.0
 Identities = 590/590 (100%), Positives = 590/590 (100%)

Query: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60
           MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW
Sbjct: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60

Query: 61  FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120
           FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL
Sbjct: 61  FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120

Query: 121 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 180
           QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT
Sbjct: 121 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 180

Query: 181 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 240
           PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG
Sbjct: 181 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 240

Query: 241 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 300
           LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC
Sbjct: 241 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 300

Query: 301 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 360
           IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL
Sbjct: 301 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 360

Query: 361 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 420
           LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE
Sbjct: 361 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 420

Query: 421 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 480
           EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT
Sbjct: 421 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 480

Query: 481 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 540
           YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN
Sbjct: 481 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 540

Query: 541 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 590
           ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI
Sbjct: 541 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 590


>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score = 1163 bits (3008), Expect = 0.0
 Identities = 590/590 (100%), Positives = 590/590 (100%)

Query: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60
           MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW
Sbjct: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60

Query: 61  FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120
           FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL
Sbjct: 61  FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120

Query: 121 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 180
           QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT
Sbjct: 121 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 180

Query: 181 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 240
           PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG
Sbjct: 181 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 240

Query: 241 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 300
           LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC
Sbjct: 241 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 300

Query: 301 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 360
           IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL
Sbjct: 301 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 360

Query: 361 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 420
           LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE
Sbjct: 361 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 420

Query: 421 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 480
           EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT
Sbjct: 421 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 480

Query: 481 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 540
           YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN
Sbjct: 481 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 540

Query: 541 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 590
           ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI
Sbjct: 541 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 590


>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
          Length = 590

 Score = 1163 bits (3008), Expect = 0.0
 Identities = 590/590 (100%), Positives = 590/590 (100%)

Query: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60
           MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW
Sbjct: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60

Query: 61  FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120
           FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL
Sbjct: 61  FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120

Query: 121 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 180
           QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT
Sbjct: 121 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 180

Query: 181 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 240
           PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG
Sbjct: 181 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 240

Query: 241 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 300
           LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC
Sbjct: 241 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 300

Query: 301 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 360
           IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL
Sbjct: 301 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 360

Query: 361 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 420
           LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE
Sbjct: 361 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 420

Query: 421 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 480
           EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT
Sbjct: 421 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 480

Query: 481 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 540
           YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN
Sbjct: 481 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 540

Query: 541 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 590
           ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI
Sbjct: 541 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 590


>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
          Length = 595

 Score = 1140 bits (2948), Expect = 0.0
 Identities = 580/586 (98%), Positives = 581/586 (99%)

Query: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60
           MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW
Sbjct: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60

Query: 61  FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120
           FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL
Sbjct: 61  FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120

Query: 121 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 180
           QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT
Sbjct: 121 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 180

Query: 181 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 240
           PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG
Sbjct: 181 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 240

Query: 241 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 300
           LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC
Sbjct: 241 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 300

Query: 301 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 360
           IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL
Sbjct: 301 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 360

Query: 361 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 420
           LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE
Sbjct: 361 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 420

Query: 421 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 480
           EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT
Sbjct: 421 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 480

Query: 481 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 540
           YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN
Sbjct: 481 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 540

Query: 541 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRR 586
           ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKK   Q  +
Sbjct: 541 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKLTLQSAK 586


>gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens]
          Length = 549

 Score = 1060 bits (2741), Expect = 0.0
 Identities = 549/590 (93%), Positives = 549/590 (93%), Gaps = 41/590 (6%)

Query: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60
           MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW
Sbjct: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60

Query: 61  FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120
           FFGLQYTIKDTVAWLKMDKKV                                       
Sbjct: 61  FFGLQYTIKDTVAWLKMDKKV--------------------------------------- 81

Query: 121 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 180
             KKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT
Sbjct: 82  --KKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 139

Query: 181 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 240
           PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG
Sbjct: 140 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 199

Query: 241 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 300
           LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC
Sbjct: 200 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 259

Query: 301 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 360
           IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL
Sbjct: 260 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 319

Query: 361 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 420
           LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE
Sbjct: 320 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 379

Query: 421 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 480
           EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT
Sbjct: 380 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 439

Query: 481 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 540
           YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN
Sbjct: 440 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 499

Query: 541 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 590
           ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI
Sbjct: 500 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 549


>gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]
          Length = 548

 Score = 1052 bits (2721), Expect = 0.0
 Identities = 548/590 (92%), Positives = 548/590 (92%), Gaps = 42/590 (7%)

Query: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60
           MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE                      
Sbjct: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE---------------------- 38

Query: 61  FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120
                               VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL
Sbjct: 39  --------------------VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 78

Query: 121 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 180
           QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT
Sbjct: 79  QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 138

Query: 181 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 240
           PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG
Sbjct: 139 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 198

Query: 241 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 300
           LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC
Sbjct: 199 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 258

Query: 301 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 360
           IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL
Sbjct: 259 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 318

Query: 361 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 420
           LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE
Sbjct: 319 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 378

Query: 421 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 480
           EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT
Sbjct: 379 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 438

Query: 481 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 540
           YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN
Sbjct: 439 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 498

Query: 541 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 590
           ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI
Sbjct: 499 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 548


>gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]
          Length = 507

 Score =  921 bits (2380), Expect = 0.0
 Identities = 474/499 (94%), Positives = 481/499 (96%)

Query: 92  VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYG 151
           ++F  L +  P+     +V    +  F  +VKKQILDEKIYCPPEASVLLASYAVQAKYG
Sbjct: 9   MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68

Query: 152 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 211
           DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA
Sbjct: 69  DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128

Query: 212 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 271
           QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF
Sbjct: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188

Query: 272 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 331
           TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR
Sbjct: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248

Query: 332 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 391
           KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT
Sbjct: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308

Query: 392 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 451
           EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA
Sbjct: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 368

Query: 452 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 511
           DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD
Sbjct: 369 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 428

Query: 512 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 571
           TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS
Sbjct: 429 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 488

Query: 572 SKHNTIKKPQAQGRRPICI 590
           SKHNTIKKPQAQGRRPICI
Sbjct: 489 SKHNTIKKPQAQGRRPICI 507


>gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens]
          Length = 507

 Score =  921 bits (2380), Expect = 0.0
 Identities = 474/499 (94%), Positives = 481/499 (96%)

Query: 92  VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYG 151
           ++F  L +  P+     +V    +  F  +VKKQILDEKIYCPPEASVLLASYAVQAKYG
Sbjct: 9   MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68

Query: 152 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 211
           DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA
Sbjct: 69  DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128

Query: 212 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 271
           QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF
Sbjct: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188

Query: 272 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 331
           TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR
Sbjct: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248

Query: 332 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 391
           KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT
Sbjct: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308

Query: 392 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 451
           EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA
Sbjct: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 368

Query: 452 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 511
           DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD
Sbjct: 369 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 428

Query: 512 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 571
           TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS
Sbjct: 429 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 488

Query: 572 SKHNTIKKPQAQGRRPICI 590
           SKHNTIKKPQAQGRRPICI
Sbjct: 489 SKHNTIKKPQAQGRRPICI 507


>gi|4506467 radixin [Homo sapiens]
          Length = 583

 Score =  501 bits (1290), Expect = e-142
 Identities = 260/569 (45%), Positives = 376/569 (66%), Gaps = 11/569 (1%)

Query: 19  PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKM 77
           PK   VR+ TMDAE+EF  +    GK LFD V +T+GLRE WFFGLQY   K    WLK+
Sbjct: 2   PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61

Query: 78  DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
           +KKV   DV KE P+ F F AKF+PE+  EEL+QEITQ LFFLQVK+ IL+++IYCPPE 
Sbjct: 62  NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121

Query: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
           +VLLASYAVQAKYGDY+  +HK G+LA + LLP+RV+  +++T E WEERI  W+ EHRG
Sbjct: 122 AVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRG 181

Query: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
             R+++ MEYLKIAQDLEMYGVNYF I+NKKGTEL LGVDALGL+IY+ +++LTPKI FP
Sbjct: 182 MLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241

Query: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
           W+EIRNIS++DK+F IKP+DKK   F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301

Query: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 377
           VQQMKAQAREEK +KQ+ER +L  EK+ RE AE+ ++ +ER   ++ E      E  +++
Sbjct: 302 VQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKA 361

Query: 378 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIK----ATAIRTEEEKRLMEQKVLEA 433
           ++  +    KA   ++E K   ++A   E+E +  +    A A +  ++ +  EQ   E 
Sbjct: 362 QKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAEL 421

Query: 434 EVLALKMA---EESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 490
                K+A   E  +++ +EA + +     A+E   + K++L  + + P  PP  P+  P
Sbjct: 422 AEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPP 481

Query: 491 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 550
              +    +      S +  +  +  ++   E+E+V   +K++ +++QL  L +E+   +
Sbjct: 482 TENEHDEHDENNAEASAELSNEGV--MNHRSEEERVTETQKNERVKKQLQALSSELAQAR 539

Query: 551 LKERETALDILHNENSDRGGSSKHNTIKK 579
            + ++T  D+LH EN  + G  K+ T+++
Sbjct: 540 DETKKTQNDVLHAENV-KAGRDKYKTLRQ 567


>gi|4505257 moesin [Homo sapiens]
          Length = 577

 Score =  496 bits (1277), Expect = e-140
 Identities = 268/569 (47%), Positives = 378/569 (66%), Gaps = 17/569 (2%)

Query: 19  PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-IKDTVAWLKM 77
           PKT +VR+ TMDAE+EF  +    GK LFD V +T+GLRE WFFGLQY   K    WLK+
Sbjct: 2   PKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61

Query: 78  DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
           +KKV   DV KE P+ F F AKFYPE+  EEL+Q+ITQ LFFLQVK+ IL++ IYCPPE 
Sbjct: 62  NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121

Query: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
           +VLLASYAVQ+KYGD++  VHK G+LA ++LLP+RV+  +++  + WEERI  W+ EHRG
Sbjct: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181

Query: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
             R++A +EYLKIAQDLEMYGVNYF+I+NKKG+EL LGVDALGL+IY+  +RLTPKI FP
Sbjct: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241

Query: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
           W+EIRNIS++DK+F IKP+DKK   F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301

Query: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELER-------RLLQMKEEATMA 370
           VQQMKAQAREEK +KQMER  L  EK+ RE AE+ ++++ER       RL Q++E+   A
Sbjct: 302 VQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKA 361

Query: 371 NEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKV 430
            + L      A  L ++ +  + EA+ LA++  EAE+  +   A    + ++K+  EQ  
Sbjct: 362 QQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKE---ALLQASRDQKKTQEQLA 418

Query: 431 LEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 490
           LE   L  ++++    R K+  +  +  Q+A+  +   ++   E+ T  + P +   PA 
Sbjct: 419 LEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAE-PAE 477

Query: 491 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 550
              D    N  G   S D +   M +     E+E+    EK++ +Q+ L  L +E+   +
Sbjct: 478 NEQDEQDEN--GAEASADLRADAMAK--DRSEEERTTEAEKNERVQKHLKALTSELANAR 533

Query: 551 LKERETALDILHNENSDRGGSSKHNTIKK 579
            + ++TA D++H EN  R G  K+ T+++
Sbjct: 534 DESKKTANDMIHAENM-RLGRDKYKTLRQ 561



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 35/158 (22%), Positives = 70/158 (44%), Gaps = 14/158 (8%)

Query: 315 SLEVQQMKAQ------AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEAT 368
           +LE+ ++ A+      AR++K  + +E Q+ A+   ++E+ E+TR EL+  +        
Sbjct: 418 ALEMAELTARISQLEMARQKKESEAVEWQQKAQ--MVQEDLEKTRAELKTAMSTPHVAEP 475

Query: 369 MANEALMRSEE----TADLLAEKA--QITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE 422
             NE   + E     +ADL A+      +EEE    A+K    ++ ++ + +      +E
Sbjct: 476 AENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDE 535

Query: 423 KRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQE 460
            +     ++ AE + L   +    R       KQ + E
Sbjct: 536 SKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDE 573


>gi|161702986 ezrin [Homo sapiens]
          Length = 586

 Score =  489 bits (1260), Expect = e-138
 Identities = 268/576 (46%), Positives = 379/576 (65%), Gaps = 22/576 (3%)

Query: 19  PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI-KDTVAWLKM 77
           PK   VR+ TMDAE+EF  +    GK LFD V +T+GLRE W+FGL Y   K    WLK+
Sbjct: 2   PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61

Query: 78  DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
           DKKV   +V KE P+ F F AKFYPE+  EEL+Q+ITQ LFFLQVK+ IL ++IYCPPE 
Sbjct: 62  DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121

Query: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
           +VLL SYAVQAK+GDY+  VHK G+L+ E L+P+RV++ +++T + WE+RI  W+AEHRG
Sbjct: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181

Query: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
             +D A +EYLKIAQDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FP
Sbjct: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241

Query: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
           W+EIRNIS++DK+F IKP+DKK   F F + +LR+NK ILQLC+GNH+L+MRRRK D++E
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIE 301

Query: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 377
           VQQMKAQAREEK +KQ+ERQ+L  EK+ RE  ER ++++ R   ++        E   ++
Sbjct: 302 VQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKA 361

Query: 378 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVL 436
           E       ++A   EEE K    +A E  + ++  +  A+R +EE +R    ++   E L
Sbjct: 362 ERELSEQIQRALQLEEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQL 417

Query: 437 ALKMAEESERRA--KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPP 493
           A ++AE + + A  +EA + K+D  E  E + RAK+   + + TK     +   P P PP
Sbjct: 418 AAELAEYTAKIALLEEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP 475

Query: 494 DI--PSFNLIGDSLSFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELK 543
            +  P    + +SL  +  +       LS E       E++++   EK++ +Q QL  L 
Sbjct: 476 PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLS 535

Query: 544 TEIEALKLKERETALDILHNENSDRGGSSKHNTIKK 579
           +E+   + + + T  DI+HNEN  R G  K+ T+++
Sbjct: 536 SELSQARDENKRTHNDIIHNENM-RQGRDKYKTLRQ 570


>gi|21614499 ezrin [Homo sapiens]
          Length = 586

 Score =  489 bits (1260), Expect = e-138
 Identities = 268/576 (46%), Positives = 379/576 (65%), Gaps = 22/576 (3%)

Query: 19  PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI-KDTVAWLKM 77
           PK   VR+ TMDAE+EF  +    GK LFD V +T+GLRE W+FGL Y   K    WLK+
Sbjct: 2   PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61

Query: 78  DKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 137
           DKKV   +V KE P+ F F AKFYPE+  EEL+Q+ITQ LFFLQVK+ IL ++IYCPPE 
Sbjct: 62  DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121

Query: 138 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 197
           +VLL SYAVQAK+GDY+  VHK G+L+ E L+P+RV++ +++T + WE+RI  W+AEHRG
Sbjct: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181

Query: 198 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 257
             +D A +EYLKIAQDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FP
Sbjct: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241

Query: 258 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 317
           W+EIRNIS++DK+F IKP+DKK   F F + +LR+NK ILQLC+GNH+L+MRRRK D++E
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIE 301

Query: 318 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 377
           VQQMKAQAREEK +KQ+ERQ+L  EK+ RE  ER ++++ R   ++        E   ++
Sbjct: 302 VQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKA 361

Query: 378 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVL 436
           E       ++A   EEE K    +A E  + ++  +  A+R +EE +R    ++   E L
Sbjct: 362 ERELSEQIQRALQLEEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQL 417

Query: 437 ALKMAEESERRA--KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPP 493
           A ++AE + + A  +EA + K+D  E  E + RAK+   + + TK     +   P P PP
Sbjct: 418 AAELAEYTAKIALLEEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP 475

Query: 494 DI--PSFNLIGDSLSFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELK 543
            +  P    + +SL  +  +       LS E       E++++   EK++ +Q QL  L 
Sbjct: 476 PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLS 535

Query: 544 TEIEALKLKERETALDILHNENSDRGGSSKHNTIKK 579
           +E+   + + + T  DI+HNEN  R G  K+ T+++
Sbjct: 536 SELSQARDENKRTHNDIIHNENM-RQGRDKYKTLRQ 570


>gi|32967268 neurofibromin 2 isoform 8 [Homo sapiens]
          Length = 165

 Score =  303 bits (777), Expect = 2e-82
 Identities = 149/149 (100%), Positives = 149/149 (100%)

Query: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60
           MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW
Sbjct: 1   MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60

Query: 61  FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120
           FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL
Sbjct: 61  FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120

Query: 121 QVKKQILDEKIYCPPEASVLLASYAVQAK 149
           QVKKQILDEKIYCPPEASVLLASYAVQAK
Sbjct: 121 QVKKQILDEKIYCPPEASVLLASYAVQAK 149


>gi|150010540 FERM domain containing 4B [Homo sapiens]
          Length = 1034

 Score =  150 bits (380), Expect = 2e-36
 Identities = 123/489 (25%), Positives = 233/489 (47%), Gaps = 51/489 (10%)

Query: 30  DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVA--WLKMDKKVLDHDVS 87
           D  +E   + K   ++L DLV     L+E  +FG+ + I DT    WL++D +VLDHD+ 
Sbjct: 68  DRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITF-IDDTGQQNWLQLDHRVLDHDLP 126

Query: 88  KEE-PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAV 146
           K+  P   HF  +FY E+    L  + T  LFFL  K  +   +I    E    LA++ +
Sbjct: 127 KKPGPTILHFAVRFYIESISF-LKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFIL 185

Query: 147 QAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEM--WEERITAWYAEHRGRARDEAE 204
           Q   GDY    + R  L      P + +   Q  P +   E+R+   Y + +G  R +A 
Sbjct: 186 QEAKGDYTSDENARKDLKTLPAFPTKTL---QEHPSLAYCEDRVIEHYLKIKGLTRGQAV 242

Query: 205 MEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNI 264
           ++Y+KI + L  YGV+Y+A+++K+G    LG+   G+  YD ++++ P+  F W ++ N+
Sbjct: 243 VQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENL 302

Query: 265 SYSDKEFTIKPLD-KKIDVFK--FNSSKLRVN---------KLILQLCIGNHDLFMRRRK 312
            + +K+F ++  D ++I V +  F  S L V          K I  + I  H  ++ R++
Sbjct: 303 YFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQ 362

Query: 313 A-----DSLEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDE 355
           +      +  + ++     E   ++  +   L  + Q              +++E + ++
Sbjct: 363 SKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSEEQ 422

Query: 356 LERRLLQMKEEATMANEALMRS-EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKA 414
              ++L++K++  +  E L++  EE   +   +A++T +  K       E   +++R   
Sbjct: 423 KREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRRVG 482

Query: 415 TAIR-------TEEEKRLMEQKVLEAE-VLALKMAEESERRAKEADQLKQDLQEAREAER 466
           TA +       +EE+  L E   LE+  ++  K+ E +++ A E D  K   ++ ++   
Sbjct: 483 TAFKLDDNLLPSEEDPALQE---LESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYT 539

Query: 467 RAKQKLLEI 475
            A +KL EI
Sbjct: 540 DAMKKLQEI 548


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
           isoform 4 [Homo sapiens]
          Length = 2490

 Score =  142 bits (358), Expect = 9e-34
 Identities = 111/365 (30%), Positives = 183/365 (50%), Gaps = 30/365 (8%)

Query: 24  VRIVTMDAE-MEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAW-----LKM 77
           V I+ ++ + +E  C+ K   KD+FD+V   +GL E   F L  T+KD   +     LK+
Sbjct: 574 VNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALA-TLKDNEYFFVDPDLKL 632

Query: 78  DKKVLDHDVSKEEP---------VTFHFLAKFYPENAEEELVQE-ITQHLFFLQVKKQIL 127
            K  +  +  KEEP          T  F  KF+ ++    L+Q  +T H ++LQ++K IL
Sbjct: 633 TK--VAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVS--LIQHTLTCHQYYLQLRKDIL 688

Query: 128 DEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEER 187
           +E+++C  E S+LLAS A+QA+YGDY P VH   +   E  LP RV+    ++    +E 
Sbjct: 689 EERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLS--YIKEE 746

Query: 188 ITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLLGVDALGLHIYD 245
           +   +  + G +  E E+E+LK+ Q L  YGV++  +    K  T +LLGV + G+ +++
Sbjct: 747 LPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFE 806

Query: 246 PENRL-TPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNH 304
             N + T  + FPW E + IS+S K+ T++     I    F +   ++ + +L LC   H
Sbjct: 807 VHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKICQYLLHLCSYQH 865

Query: 305 DLFMRRRKADSLEVQQMKAQAREEKARKQMERQR---LAREKQMREEAERTRDELERRLL 361
              ++ R   S +  Q   +A       Q E  R   + R       A  T ++L  R L
Sbjct: 866 KFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPL 925

Query: 362 QMKEE 366
            ++ E
Sbjct: 926 SVQAE 930


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
           isoform 1 [Homo sapiens]
          Length = 2485

 Score =  142 bits (358), Expect = 9e-34
 Identities = 111/365 (30%), Positives = 183/365 (50%), Gaps = 30/365 (8%)

Query: 24  VRIVTMDAE-MEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAW-----LKM 77
           V I+ ++ + +E  C+ K   KD+FD+V   +GL E   F L  T+KD   +     LK+
Sbjct: 574 VNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALA-TLKDNEYFFVDPDLKL 632

Query: 78  DKKVLDHDVSKEEP---------VTFHFLAKFYPENAEEELVQE-ITQHLFFLQVKKQIL 127
            K  +  +  KEEP          T  F  KF+ ++    L+Q  +T H ++LQ++K IL
Sbjct: 633 TK--VAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVS--LIQHTLTCHQYYLQLRKDIL 688

Query: 128 DEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEER 187
           +E+++C  E S+LLAS A+QA+YGDY P VH   +   E  LP RV+    ++    +E 
Sbjct: 689 EERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLS--YIKEE 746

Query: 188 ITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLLGVDALGLHIYD 245
           +   +  + G +  E E+E+LK+ Q L  YGV++  +    K  T +LLGV + G+ +++
Sbjct: 747 LPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFE 806

Query: 246 PENRL-TPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNH 304
             N + T  + FPW E + IS+S K+ T++     I    F +   ++ + +L LC   H
Sbjct: 807 VHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKICQYLLHLCSYQH 865

Query: 305 DLFMRRRKADSLEVQQMKAQAREEKARKQMERQR---LAREKQMREEAERTRDELERRLL 361
              ++ R   S +  Q   +A       Q E  R   + R       A  T ++L  R L
Sbjct: 866 KFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPL 925

Query: 362 QMKEE 366
            ++ E
Sbjct: 926 SVQAE 930


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13
           isoform 2 [Homo sapiens]
          Length = 2466

 Score =  142 bits (358), Expect = 9e-34
 Identities = 111/365 (30%), Positives = 183/365 (50%), Gaps = 30/365 (8%)

Query: 24  VRIVTMDAE-MEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAW-----LKM 77
           V I+ ++ + +E  C+ K   KD+FD+V   +GL E   F L  T+KD   +     LK+
Sbjct: 574 VNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALA-TLKDNEYFFVDPDLKL 632

Query: 78  DKKVLDHDVSKEEP---------VTFHFLAKFYPENAEEELVQE-ITQHLFFLQVKKQIL 127
            K  +  +  KEEP          T  F  KF+ ++    L+Q  +T H ++LQ++K IL
Sbjct: 633 TK--VAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVS--LIQHTLTCHQYYLQLRKDIL 688

Query: 128 DEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEER 187
           +E+++C  E S+LLAS A+QA+YGDY P VH   +   E  LP RV+    ++    +E 
Sbjct: 689 EERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLS--YIKEE 746

Query: 188 ITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLLGVDALGLHIYD 245
           +   +  + G +  E E+E+LK+ Q L  YGV++  +    K  T +LLGV + G+ +++
Sbjct: 747 LPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFE 806

Query: 246 PENRL-TPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNH 304
             N + T  + FPW E + IS+S K+ T++     I    F +   ++ + +L LC   H
Sbjct: 807 VHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKICQYLLHLCSYQH 865

Query: 305 DLFMRRRKADSLEVQQMKAQAREEKARKQMERQR---LAREKQMREEAERTRDELERRLL 361
              ++ R   S +  Q   +A       Q E  R   + R       A  T ++L  R L
Sbjct: 866 KFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPL 925

Query: 362 QMKEE 366
            ++ E
Sbjct: 926 SVQAE 930


>gi|116063562 FERM domain containing 4A [Homo sapiens]
          Length = 1039

 Score =  142 bits (357), Expect = 1e-33
 Identities = 119/484 (24%), Positives = 219/484 (45%), Gaps = 40/484 (8%)

Query: 30  DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDT-VAWLKMDKKVLDHDVSK 88
           D ++E   + K   K+L DLV     L+E  +FG+ +T +   + WL++D++VL+HD  K
Sbjct: 29  DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPK 88

Query: 89  EE-PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQ 147
           +  PV  +F  +FY E+    L    T  LFFL  K  I  E I    E    LASY +Q
Sbjct: 89  KSGPVVLYFCVRFYIESISY-LKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQ 147

Query: 148 AKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEY 207
              GD+  +   R  L +   LP + +  +       E+R+   Y +  G+ R +A + Y
Sbjct: 148 EAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYC-EDRVIEHYKKLNGQTRGQAIVNY 206

Query: 208 LKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYS 267
           + I + L  YGV+Y+A+++K+G    LG+   G+  YD  +++ P+  F W ++ N+ + 
Sbjct: 207 MSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFR 266

Query: 268 DKEFTIK---PLDKKIDVFKFNSSKLRVN---------KLILQLCIGNHDLFMRRRKADS 315
           +K+F+++   P    +    F  S + V+         K I  + I  H  ++ R+++ S
Sbjct: 267 EKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRKQSKS 326

Query: 316 -----LEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDELER 358
                  + ++     E    K  +   +  + ++             +E++ ++   + 
Sbjct: 327 KIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKKD 386

Query: 359 RLLQMKEEATMANEAL-MRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAI 417
            L  +K       E L  R EE   L   +A++T +          E    ++R   TA 
Sbjct: 387 MLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEPPIVRRRIGTAF 446

Query: 418 RTEEEKRLMEQKVLEAEVLALKMA------EESERRAKEADQLKQDLQEAREAERRAKQK 471
           + +E+K L + +  E E L  + A      E + R A + +  K+  ++ + +   A +K
Sbjct: 447 KLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKKLKKQRKTSYLNALKK 506

Query: 472 LLEI 475
           L EI
Sbjct: 507 LQEI 510


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
           isoform 3 [Homo sapiens]
          Length = 2294

 Score =  140 bits (353), Expect = 3e-33
 Identities = 101/312 (32%), Positives = 167/312 (53%), Gaps = 29/312 (9%)

Query: 24  VRIVTMDAE-MEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAW-----LKM 77
           V I+ ++ + +E  C+ K   KD+FD+V   +GL E   F L  T+KD   +     LK+
Sbjct: 574 VNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALA-TLKDNEYFFVDPDLKL 632

Query: 78  DKKVLDHDVSKEEP---------VTFHFLAKFYPENAEEELVQE-ITQHLFFLQVKKQIL 127
            K  +  +  KEEP          T  F  KF+ ++    L+Q  +T H ++LQ++K IL
Sbjct: 633 TK--VAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVS--LIQHTLTCHQYYLQLRKDIL 688

Query: 128 DEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEER 187
           +E+++C  E S+LLAS A+QA+YGDY P VH   +   E  LP RV+    ++    +E 
Sbjct: 689 EERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLS--YIKEE 746

Query: 188 ITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLLGVDALGLHIYD 245
           +   +  + G +  E E+E+LK+ Q L  YGV++  +    K  T +LLGV + G+ +++
Sbjct: 747 LPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFE 806

Query: 246 PENRL-TPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNH 304
             N + T  + FPW E + IS+S K+ T++     I    F +   ++ + +L LC   H
Sbjct: 807 VHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKICQYLLHLCSYQH 865

Query: 305 --DLFMRRRKAD 314
              L MR R+++
Sbjct: 866 KFQLQMRARQSN 877


>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
           [Homo sapiens]
          Length = 779

 Score =  139 bits (350), Expect = 7e-33
 Identities = 97/298 (32%), Positives = 151/298 (50%), Gaps = 22/298 (7%)

Query: 17  KQPKTFTVRIVTMDAEMEFNCEMK--WKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVA- 73
           K+ K+   R+  +DA  E+ CE++   +G+ LFDLVC  L L E  +FGL +   D+   
Sbjct: 30  KKYKSAICRVTLLDAS-EYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKN 88

Query: 74  WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 133
           WL   K++      +  P  F F  KFYP +  + L ++IT++   LQ++  I+  ++ C
Sbjct: 89  WLDPSKEIKKQ--IRSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPC 145

Query: 134 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYA 193
                 LL SYAVQA+ GDYD   H   ++++    P +   L        EERI   + 
Sbjct: 146 SFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHK 197

Query: 194 EHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPK 253
            +RG    EAE+ +L+ A+ L MYGV+    ++ +G +++LGV A GL IY    R+   
Sbjct: 198 TYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN-- 255

Query: 254 ISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 307
             F W +I  ISY    F IK    + + F+    F     R  K + ++CI +H  F
Sbjct: 256 -RFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 312


>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
           [Homo sapiens]
          Length = 881

 Score =  139 bits (350), Expect = 7e-33
 Identities = 97/298 (32%), Positives = 151/298 (50%), Gaps = 22/298 (7%)

Query: 17  KQPKTFTVRIVTMDAEMEFNCEMK--WKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVA- 73
           K+ K+   R+  +DA  E+ CE++   +G+ LFDLVC  L L E  +FGL +   D+   
Sbjct: 92  KKYKSAICRVTLLDAS-EYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKN 150

Query: 74  WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 133
           WL   K++      +  P  F F  KFYP +  + L ++IT++   LQ++  I+  ++ C
Sbjct: 151 WLDPSKEIKKQ--IRSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPC 207

Query: 134 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYA 193
                 LL SYAVQA+ GDYD   H   ++++    P +   L        EERI   + 
Sbjct: 208 SFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHK 259

Query: 194 EHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPK 253
            +RG    EAE+ +L+ A+ L MYGV+    ++ +G +++LGV A GL IY    R+   
Sbjct: 260 TYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN-- 317

Query: 254 ISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 307
             F W +I  ISY    F IK    + + F+    F     R  K + ++CI +H  F
Sbjct: 318 -RFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 374


>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
           sapiens]
          Length = 926

 Score =  137 bits (346), Expect = 2e-32
 Identities = 95/304 (31%), Positives = 159/304 (52%), Gaps = 21/304 (6%)

Query: 12  SSLKRKQPKTFTV-RIVTMDAEME-FNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYT-- 67
           S L R +  T  V  I+ +D  ++ F      +G+ L D+V + L L E  +FGLQ    
Sbjct: 18  SELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADD 77

Query: 68  IKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQIL 127
             D   WL  +K +    + +  P + +F  KF+  +  + L +E T++ +FLQ+K+ IL
Sbjct: 78  STDNPRWLDPNKPIRKQ-LKRGSPYSLNFRVKFFVSDPNK-LQEEYTRYQYFLQIKQDIL 135

Query: 128 DEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEER 187
             ++ CP   + LLAS+AVQ++ GDYD S +  G+L+    +P +        P+ +E+ 
Sbjct: 136 TGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQ--------PQDFEKE 187

Query: 188 ITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPE 247
           I   + +H G +  EAE  YL  A+ LE+YGV +   R++   E+++GV + G+ IY   
Sbjct: 188 IAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNR 247

Query: 248 NRLTPKISFPWNEIRNISYSDKEFTI---KPL-DKKIDVFKFNSSKLRVNKLILQLCIGN 303
            R+    +FPW +I  IS+  K+F I   K L + +  +  FN    R  K + + C+ +
Sbjct: 248 VRMN---TFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEH 304

Query: 304 HDLF 307
           H  F
Sbjct: 305 HTFF 308


>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
           isoform 2 [Homo sapiens]
          Length = 868

 Score =  135 bits (339), Expect = 1e-31
 Identities = 83/275 (30%), Positives = 144/275 (52%), Gaps = 19/275 (6%)

Query: 43  GKDLFDLVCRTLGLRETWFFGLQYTIK--DTVAWLKMDKKVLDHDVSKEEPVTFHFLAKF 100
           G+ L D+V   LG+ E  +FGLQ+     D+  WL+  K +    +    P T HF  +F
Sbjct: 51  GQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQ-LKGGFPCTLHFRVRF 109

Query: 101 YPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKR 160
           +  +    L QE T+HL+FLQ+K  I + ++ CP  ++V+LASYAVQ+ +GDY+ S+H  
Sbjct: 110 FIPDPNT-LQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHP 168

Query: 161 GFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVN 220
           G+L+    +P +         E +  ++ + + +H G  + EAE  Y+ IA+ L+ YGV 
Sbjct: 169 GYLSDSHFIPDQ--------NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVE 220

Query: 221 YFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTI----KPL 276
             + R+    +L++G+ + G+ +Y    +      +PW  I  IS+  K+F I    K  
Sbjct: 221 LHSGRDLHNLDLMIGIASAGVAVY---RKYICTSFYPWVNILKISFKRKKFFIHQRQKQA 277

Query: 277 DKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRR 311
           + +  +  FN    R  K + + C+ +H  F  ++
Sbjct: 278 ESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312


>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
           isoform 1 [Homo sapiens]
          Length = 913

 Score =  135 bits (339), Expect = 1e-31
 Identities = 83/275 (30%), Positives = 144/275 (52%), Gaps = 19/275 (6%)

Query: 43  GKDLFDLVCRTLGLRETWFFGLQYTIK--DTVAWLKMDKKVLDHDVSKEEPVTFHFLAKF 100
           G+ L D+V   LG+ E  +FGLQ+     D+  WL+  K +    +    P T HF  +F
Sbjct: 51  GQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQ-LKGGFPCTLHFRVRF 109

Query: 101 YPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKR 160
           +  +    L QE T+HL+FLQ+K  I + ++ CP  ++V+LASYAVQ+ +GDY+ S+H  
Sbjct: 110 FIPDPNT-LQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHP 168

Query: 161 GFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVN 220
           G+L+    +P +         E +  ++ + + +H G  + EAE  Y+ IA+ L+ YGV 
Sbjct: 169 GYLSDSHFIPDQ--------NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVE 220

Query: 221 YFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTI----KPL 276
             + R+    +L++G+ + G+ +Y    +      +PW  I  IS+  K+F I    K  
Sbjct: 221 LHSGRDLHNLDLMIGIASAGVAVY---RKYICTSFYPWVNILKISFKRKKFFIHQRQKQA 277

Query: 277 DKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRR 311
           + +  +  FN    R  K + + C+ +H  F  ++
Sbjct: 278 ESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312


>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
           sapiens]
          Length = 1087

 Score =  134 bits (338), Expect = 2e-31
 Identities = 95/310 (30%), Positives = 155/310 (50%), Gaps = 23/310 (7%)

Query: 6   ASRMSFSSLKR-KQPKTFTVRIVTMDAEMEFNC--EMKWKGKDLFDLVCRTLGLRETWFF 62
           +S++S S LK  K+PK+   +++ +D   E+ C  E + +G+ LFD VC  L L E  +F
Sbjct: 93  SSKLSRSPLKIVKKPKSMQCKVILLDGS-EYTCDVEKRSRGQVLFDKVCEHLNLLEKDYF 151

Query: 63  GLQYT-IKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQ 121
           GL Y   ++   WL   K++      +     F F  KFYP +  + L ++IT++   LQ
Sbjct: 152 GLTYRDAENQKNWLDPAKEIKKQ--VRSGAWHFSFNVKFYPPDPAQ-LSEDITRYYLCLQ 208

Query: 122 VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTP 181
           ++  I+  ++ C      LL SY VQ++ GDYDP      ++++    P     L     
Sbjct: 209 LRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKEL----- 263

Query: 182 EMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGL 241
              E+++   +  HRG    EAEM +L+ A+ L MYGV+    ++ +G E++LGV A GL
Sbjct: 264 ---EDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGL 320

Query: 242 HIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLIL 297
            IY    R+     F W ++  ISY    F IK    + + F+    F     R  K + 
Sbjct: 321 LIYRDRLRIN---RFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLW 377

Query: 298 QLCIGNHDLF 307
           ++C+ +H  F
Sbjct: 378 KVCVEHHTFF 387


>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
           RH-linked) isoform 3 [Homo sapiens]
          Length = 588

 Score =  132 bits (332), Expect = 9e-31
 Identities = 110/471 (23%), Positives = 207/471 (43%), Gaps = 25/471 (5%)

Query: 30  DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTV-AWLKMDKKVLDHDVSK 88
           D   E   E   KG+DL   VC  L L E  +FGL      T   WL   K++      +
Sbjct: 10  DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQ--VR 67

Query: 89  EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148
             P  F F  KFYP +  + L ++IT++   LQ+++ I+  ++ C      LL SY +Q+
Sbjct: 68  GVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126

Query: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208
           + GDYDP +H   +++  +L P +   L        EE++   +  +R     +A++E+L
Sbjct: 127 ELGDYDPELHGVDYVSDFKLAPNQTKEL--------EEKVMELHKSYRSMTPAQADLEFL 178

Query: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268
           + A+ L MYGV+    ++ +G +++LGV + GL +Y  + R+     FPW ++  ISY  
Sbjct: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKR 235

Query: 269 KEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324
             F IK    + + ++    F     R  K + ++C+  H  F R    D++   +  A 
Sbjct: 236 SSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLAL 294

Query: 325 AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLL 384
             + +   + + Q       +   A        +R  +  + A   + A      T+   
Sbjct: 295 GSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPA 354

Query: 385 AEKAQITEEEA-KLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE 443
             + Q+ E       A+K    + + + +KA   + +E     E +  EA     +  + 
Sbjct: 355 ITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDG 414

Query: 444 SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPD 494
                + ++ + +DL +++E  ++    + E+  K  +  M  +P P P +
Sbjct: 415 ENIYIRHSNLMLEDLDKSQEEIKKHHASISEL--KKNF--MESVPEPRPSE 461


>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score =  128 bits (322), Expect = 1e-29
 Identities = 89/298 (29%), Positives = 150/298 (50%), Gaps = 22/298 (7%)

Query: 17  KQPKTFTVRIVTMDAEMEFNCEMKW--KGKDLFDLVCRTLGLRETWFFGLQYTIK-DTVA 73
           K+ KT   ++  +D   E++C+++   KG+ LFD VC  L L E  +FGL +    +   
Sbjct: 213 KKTKTVQCKVTLLDGT-EYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKN 271

Query: 74  WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 133
           WL   K++      +  P  F F  KFYP +  + L ++IT++   LQ+++ I   ++ C
Sbjct: 272 WLDPAKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPC 328

Query: 134 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYA 193
                 LL SY +QA+ GDYDP  H    L++ +  P +   L        EE++   + 
Sbjct: 329 SFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL--------EEKVAELHK 380

Query: 194 EHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPK 253
            HRG +  +A+ ++L+ A+ L MYGV+    ++ +G ++ LGV A GL IY    R+   
Sbjct: 381 THRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN-- 438

Query: 254 ISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 307
             F W +I  ISY    F IK    +++ F+    F     R  K + ++C+ +H  +
Sbjct: 439 -RFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495


>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score =  128 bits (322), Expect = 1e-29
 Identities = 89/298 (29%), Positives = 150/298 (50%), Gaps = 22/298 (7%)

Query: 17  KQPKTFTVRIVTMDAEMEFNCEMKW--KGKDLFDLVCRTLGLRETWFFGLQYTIK-DTVA 73
           K+ KT   ++  +D   E++C+++   KG+ LFD VC  L L E  +FGL +    +   
Sbjct: 213 KKTKTVQCKVTLLDGT-EYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKN 271

Query: 74  WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 133
           WL   K++      +  P  F F  KFYP +  + L ++IT++   LQ+++ I   ++ C
Sbjct: 272 WLDPAKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPC 328

Query: 134 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYA 193
                 LL SY +QA+ GDYDP  H    L++ +  P +   L        EE++   + 
Sbjct: 329 SFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL--------EEKVAELHK 380

Query: 194 EHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPK 253
            HRG +  +A+ ++L+ A+ L MYGV+    ++ +G ++ LGV A GL IY    R+   
Sbjct: 381 THRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN-- 438

Query: 254 ISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 307
             F W +I  ISY    F IK    +++ F+    F     R  K + ++C+ +H  +
Sbjct: 439 -RFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495


>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
           [Homo sapiens]
          Length = 1005

 Score =  128 bits (322), Expect = 1e-29
 Identities = 89/298 (29%), Positives = 150/298 (50%), Gaps = 22/298 (7%)

Query: 17  KQPKTFTVRIVTMDAEMEFNCEMKW--KGKDLFDLVCRTLGLRETWFFGLQYTIK-DTVA 73
           K+ KT   ++  +D   E++C+++   KG+ LFD VC  L L E  +FGL +    +   
Sbjct: 213 KKTKTVQCKVTLLDGT-EYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKN 271

Query: 74  WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 133
           WL   K++      +  P  F F  KFYP +  + L ++IT++   LQ+++ I   ++ C
Sbjct: 272 WLDPAKEIKRQ--LRNLPWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPC 328

Query: 134 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYA 193
                 LL SY +QA+ GDYDP  H    L++ +  P +   L        EE++   + 
Sbjct: 329 SFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKEL--------EEKVAELHK 380

Query: 194 EHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPK 253
            HRG +  +A+ ++L+ A+ L MYGV+    ++ +G ++ LGV A GL IY    R+   
Sbjct: 381 THRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN-- 438

Query: 254 ISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 307
             F W +I  ISY    F IK    +++ F+    F     R  K + ++C+ +H  +
Sbjct: 439 -RFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495


>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
           1, RH-linked) isoform 2 [Homo sapiens]
          Length = 641

 Score =  126 bits (317), Expect = 5e-29
 Identities = 101/410 (24%), Positives = 181/410 (44%), Gaps = 21/410 (5%)

Query: 30  DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTV-AWLKMDKKVLDHDVSK 88
           D   E   E   KG+DL   VC  L L E  +FGL      T   WL   K++      +
Sbjct: 10  DTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQ--VR 67

Query: 89  EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 148
             P  F F  KFYP +  + L ++IT++   LQ+++ I+  ++ C      LL SY +Q+
Sbjct: 68  GVPWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQS 126

Query: 149 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 208
           + GDYDP +H   +++  +L P +   L        EE++   +  +R     +A++E+L
Sbjct: 127 ELGDYDPELHGVDYVSDFKLAPNQTKEL--------EEKVMELHKSYRSMTPAQADLEFL 178

Query: 209 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 268
           + A+ L MYGV+    ++ +G +++LGV + GL +Y  + R+     FPW ++  ISY  
Sbjct: 179 ENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKR 235

Query: 269 KEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQ 324
             F IK    + + ++    F     R  K + ++C+  H  F R    D++   +  A 
Sbjct: 236 SSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLAL 294

Query: 325 AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLL 384
             + +   + + Q       +   A        +R  +  + A   + A      T+   
Sbjct: 295 GSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPA 354

Query: 385 AEKAQITEEEA-KLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEA 433
             + Q+ E       A+K    + + + +KA   + +E     E +  EA
Sbjct: 355 ITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEA 404


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.131    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,632,446
Number of Sequences: 37866
Number of extensions: 952527
Number of successful extensions: 20938
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 546
Number of HSP's successfully gapped in prelim test: 1059
Number of HSP's that attempted gapping in prelim test: 7585
Number of HSP's gapped (non-prelim): 7167
length of query: 590
length of database: 18,247,518
effective HSP length: 108
effective length of query: 482
effective length of database: 14,157,990
effective search space: 6824151180
effective search space used: 6824151180
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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