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Search of human proteins with 32490572
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
(1087 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 2161 0.0
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 634 0.0
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 620 e-177
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 582 e-166
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 582 e-166
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 582 e-166
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 525 e-149
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 525 e-149
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 486 e-137
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 308 1e-83
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 278 2e-74
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 269 1e-71
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 269 1e-71
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 268 3e-71
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 263 7e-70
gi|117500790 FERM domain containing 3 [Homo sapiens] 261 3e-69
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 257 4e-68
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 248 2e-65
gi|34916000 FERM domain containing 7 [Homo sapiens] 243 7e-64
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 224 4e-58
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 223 8e-58
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 164 4e-40
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i... 153 1e-36
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 152 2e-36
gi|161702986 ezrin [Homo sapiens] 146 1e-34
gi|21614499 ezrin [Homo sapiens] 146 1e-34
gi|4505257 moesin [Homo sapiens] 138 3e-32
gi|4506467 radixin [Homo sapiens] 137 7e-32
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 134 4e-31
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 134 4e-31
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 2161 bits (5600), Expect = 0.0
Identities = 1087/1087 (100%), Positives = 1087/1087 (100%)
Query: 1 MTTESGSDSESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRR 60
MTTESGSDSESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRR
Sbjct: 1 MTTESGSDSESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRR 60
Query: 61 EVTDKEQEFAARAAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGS 120
EVTDKEQEFAARAAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGS
Sbjct: 61 EVTDKEQEFAARAAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGS 120
Query: 121 EYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAW 180
EYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAW
Sbjct: 121 EYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAW 180
Query: 181 HFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDY 240
HFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDY
Sbjct: 181 HFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDY 240
Query: 241 DPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDL 300
DPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDL
Sbjct: 241 DPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDL 300
Query: 301 HHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFE 360
HHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFE
Sbjct: 301 HHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFE 360
Query: 361 STIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRAS 420
STIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRAS
Sbjct: 361 STIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRAS 420
Query: 421 ALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYATTKGISQTNLITTVTPEKKAEEERDE 480
ALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYATTKGISQTNLITTVTPEKKAEEERDE
Sbjct: 421 ALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYATTKGISQTNLITTVTPEKKAEEERDE 480
Query: 481 EEDKRRKGEEVTPISAIRHEGKSPGLGTDSCPLSPPSTHCAPTSPTELRRRCKENDCKLP 540
EEDKRRKGEEVTPISAIRHEGKSPGLGTDSCPLSPPSTHCAPTSPTELRRRCKENDCKLP
Sbjct: 481 EEDKRRKGEEVTPISAIRHEGKSPGLGTDSCPLSPPSTHCAPTSPTELRRRCKENDCKLP 540
Query: 541 GYEPSRAEHLPGEPALDSDGPGRPYLGDQDVAFSYRQQTGKGTTLFSFSLQLPESFPSLL 600
GYEPSRAEHLPGEPALDSDGPGRPYLGDQDVAFSYRQQTGKGTTLFSFSLQLPESFPSLL
Sbjct: 541 GYEPSRAEHLPGEPALDSDGPGRPYLGDQDVAFSYRQQTGKGTTLFSFSLQLPESFPSLL 600
Query: 601 DDDGYLSFPNLSETNLLPQSLQHYLPIRSPSLVPCFLFIFFFLLSASFSVPYALTLSFPL 660
DDDGYLSFPNLSETNLLPQSLQHYLPIRSPSLVPCFLFIFFFLLSASFSVPYALTLSFPL
Sbjct: 601 DDDGYLSFPNLSETNLLPQSLQHYLPIRSPSLVPCFLFIFFFLLSASFSVPYALTLSFPL 660
Query: 661 ALCLCYLEPKAASLSASLDNDPSDSSEEETDSERTDTAADGETTATESDQEEDAELKAQE 720
ALCLCYLEPKAASLSASLDNDPSDSSEEETDSERTDTAADGETTATESDQEEDAELKAQE
Sbjct: 661 ALCLCYLEPKAASLSASLDNDPSDSSEEETDSERTDTAADGETTATESDQEEDAELKAQE 720
Query: 721 LEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLSTSPVRLAARQEDAPMIEPLV 780
LEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLSTSPVRLAARQEDAPMIEPLV
Sbjct: 721 LEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLSTSPVRLAARQEDAPMIEPLV 780
Query: 781 PEETKQSSGEKLMDGSEIFSLLESARKPTEFIGGVTSTSQSWVQKMETKTESSGIETEPT 840
PEETKQSSGEKLMDGSEIFSLLESARKPTEFIGGVTSTSQSWVQKMETKTESSGIETEPT
Sbjct: 781 PEETKQSSGEKLMDGSEIFSLLESARKPTEFIGGVTSTSQSWVQKMETKTESSGIETEPT 840
Query: 841 VHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG 900
VHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
Sbjct: 841 VHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG 900
Query: 901 AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGS 960
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGS
Sbjct: 901 AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGS 960
Query: 961 VSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVLMSAQTITSETTSTTTTT 1020
VSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVLMSAQTITSETTSTTTTT
Sbjct: 961 VSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVLMSAQTITSETTSTTTTT 1020
Query: 1021 HITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI 1080
HITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI
Sbjct: 1021 HITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI 1080
Query: 1081 TPEDGED 1087
TPEDGED
Sbjct: 1081 TPEDGED 1087
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 634 bits (1635), Expect = 0.0
Identities = 339/570 (59%), Positives = 400/570 (70%), Gaps = 36/570 (6%)
Query: 1 MTTESGSDSESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRR 60
MTTE+G DSE K QE PQ Q A A V P A H P
Sbjct: 1 MTTETGPDSEVKKAQEEAPQ-----QPEAAAAVTTP------------VTPAGHGHPEAN 43
Query: 61 EVTDKEQEFAARAAKQL----EYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVIL 116
+ R A+Q E E D LS++++ SK +SP KI KK KS C+V L
Sbjct: 44 SNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTL 103
Query: 117 LDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVR 176
LD SEY C+VEK RGQVLFD VCEHLNLLEKDYFGLT+ DA++QKNWLDP+KEIKKQ+R
Sbjct: 104 LDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIR 163
Query: 177 SGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSE 236
S W+F+F VKFYPPDPAQL+EDITRYYLCLQLR DI++GRLPCSFVT ALLGSY VQ+E
Sbjct: 164 SSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAE 223
Query: 237 LGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMY 296
LGDYD +E +Y+SE RFAPN T+ELE++++ELHK++RGMTP EAE+HFLENAKKLSMY
Sbjct: 224 LGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMY 283
Query: 297 GVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEF 356
GVDLHHAKDSEG++IMLGVCA+GLLIYRDRLRINRFAWPK+LKISYKR+NFYIKIRPGE+
Sbjct: 284 GVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEY 343
Query: 357 EQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQT 416
EQFESTIGFKLPNHR+AKRLWKVC+EHHTFFRL+ PE PPK FL +GSKFRYSGRTQAQT
Sbjct: 344 EQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQT 403
Query: 417 RRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYATTKGISQTNLITTVTPEKKAEE 476
R+ASALIDRPAP+FERSSSKRYTMSRSLDG +++ +S+ + P+ +
Sbjct: 404 RQASALIDRPAPFFERSSSKRYTMSRSLDG----AEFSRPASVSENH---DAGPDGDKRD 456
Query: 477 ERDEEEDKRRKGEE-----VTPISAIRHEGKSPGLGTDSCPLSPPSTHCA-PTSPTELRR 530
E E +R + EE T I ++ E ++ P S EL+R
Sbjct: 457 EDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKR 516
Query: 531 RCKENDCKL--PGYEPSRAEHLPGEPALDS 558
KE + KL + R LP PA S
Sbjct: 517 TLKEPNSKLIHRDRDWERERRLPSSPASPS 546
Score = 146 bits (368), Expect = 1e-34
Identities = 137/438 (31%), Positives = 209/438 (47%), Gaps = 53/438 (12%)
Query: 680 NDPSDSSEEETDSERTDTAADGETTATESDQEEDAELKAQELEKTQDDLMKHQTNISELK 739
++ +S + +++E + + + +QE K + L+K +D L+KHQ +I+ELK
Sbjct: 456 DEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELK 515
Query: 740 RTFLETSTDTAVTN---EWEKRLSTSPV-------------RLAARQEDAPMIEPLVPEE 783
RT E ++ + E E+RL +SP R R+ ++P P
Sbjct: 516 RTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRA 575
Query: 784 TKQSSGEKLMDGSEIFSLLES-----ARKPTEFIGGVTSTSQSWVQKMETKTESSGIETE 838
+ +G++ D L+ RK + TS+ ++ V + G E
Sbjct: 576 PESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAEVD-FTVIGDYHGSAFE 634
Query: 839 PTVHHLP-LSTEKVVQETVLVEERRVVH----ASGDASYSAGDSGDAAA-----QPAFTG 888
LP L +K +T + R ++ + D S DS D A P F
Sbjct: 635 DFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEP 694
Query: 889 IKGKEGSALTEGAKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFES 948
+K + + + +++ E AVL Q +A +Q + SA++ E + P
Sbjct: 695 VKTETMTVSSLAIRKKIEPE---AVL-QTRVSAMDNTQQVDGSASVG-REFIATTP---- 745
Query: 949 STVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDP--GTDLEPGVLMSA 1006
++ TETIS + +K S K + +T+ E + P G D VL S
Sbjct: 746 -SITTETIS--TTMENSLK---SGKGAAAMIPGPQTVATEIRSLSPIIGKD----VLTST 795
Query: 1007 QTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPD 1066
T+ET ST+TTTH+TKTVKGG SETRIEKRI+ITGD D+D DQALA AIKEAK QHPD
Sbjct: 796 YGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPD 855
Query: 1067 MSVTKVVVHKETEITPED 1084
M VTK VV++ET+ +PE+
Sbjct: 856 MLVTKAVVYRETDPSPEE 873
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 620 bits (1599), Expect = e-177
Identities = 316/478 (66%), Positives = 371/478 (77%), Gaps = 15/478 (3%)
Query: 83 EDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEH 142
E D LS++++ SK +SP KI KK KS C+V LLD SEY C+VEK RGQVLFD VCEH
Sbjct: 8 EADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEH 67
Query: 143 LNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITR 202
LNLLEKDYFGLT+ DA++QKNWLDP+KEIKKQ+RS W+F+F VKFYPPDPAQL+EDITR
Sbjct: 68 LNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITR 127
Query: 203 YYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKE 262
YYLCLQLR DI++GRLPCSFVT ALLGSY VQ+ELGDYD +E +Y+SE RFAPN T+E
Sbjct: 128 YYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRE 187
Query: 263 LEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLI 322
LE++++ELHK++RGMTP EAE+HFLENAKKLSMYGVDLHHAKDSEG++IMLGVCA+GLLI
Sbjct: 188 LEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLI 247
Query: 323 YRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVE 382
YRDRLRINRFAWPK+LKISYKR+NFYIKIRPGE+EQFESTIGFKLPNHR+AKRLWKVC+E
Sbjct: 248 YRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIE 307
Query: 383 HHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSR 442
HHTFFRL+ PE PPK FL +GSKFRYSGRTQAQTR+ASALIDRPAP+FERSSSKRYTMSR
Sbjct: 308 HHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSR 367
Query: 443 SLDGEVGTGQYATTKGISQTNLITTVTPEKKAEEERDEEEDKRRKGEEVTPISAIRHEGK 502
SLDG +++ +S+ + P+ +E E +R + EE +R K
Sbjct: 368 SLDG----AEFSRPASVSENH---DAGPDGDKRDEDGESGGQRSEAEE----GEVRTPTK 416
Query: 503 SPGLGTDSCPLSPPSTHCAPTSPTELRRRCKENDCKL--PGYEPSRAEHLPGEPALDS 558
L P H A S EL+R KE + KL + R LP PA S
Sbjct: 417 IKELKFLDKPEDVLLKHQA--SINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPS 472
Score = 145 bits (366), Expect = 2e-34
Identities = 142/463 (30%), Positives = 213/463 (46%), Gaps = 100/463 (21%)
Query: 670 KAASLSASLDN-------DPSDSSEEETDSERTDTAADGETTATESDQEED---AELKAQ 719
K ++S SLD S++ + D ++ D DGE+ S+ EE K +
Sbjct: 361 KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDE--DGESGGQRSEAEEGEVRTPTKIK 418
Query: 720 EL---EKTQDDLMKHQTNISELKRTFLETSTDTAVTN---EWEKRLSTSPVRLAARQEDA 773
EL +K +D L+KHQ +I+ELKRT E ++ + E E+RL +SP + +
Sbjct: 419 ELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKG--- 475
Query: 774 PMIEPLVPEETKQSSGEKLMDGSEIFSLLESARKPTEFIGGVTSTSQSWVQKMETKTESS 833
PE+ + +G L +GSE E + P + E+ T
Sbjct: 476 ------TPEKANERAG--LREGSE-----EKVKPPRP-------------RAPESDTGDE 509
Query: 834 GIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKE 893
+ E ++TV +++ + +S + + A+ FT I
Sbjct: 510 DQDQE--------------RDTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYH 555
Query: 894 GSA-------LTEGAKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISE-----TLE 941
GSA L E +++ + + ++ A Q+++S I S +
Sbjct: 556 GSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPS--QDDESGGIEDSPDRGACSTP 613
Query: 942 QKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS--------QVD 993
P FE VKTET++ S++ ++ +I + V T E+S +
Sbjct: 614 DMPQFEP--VKTETMTVSSLA---IRKKIEPEAVLQTRVSAMDNTQENSLKSGKGAAAMI 668
Query: 994 PGTD--------LEP----GVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVI 1041
PG L P VL S T+ET ST+TTTH+TKTVKGG SETRIEKRI+I
Sbjct: 669 PGPQTVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIII 728
Query: 1042 TGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPED 1084
TGD D+D DQALA AIKEAK QHPDM VTK VV++ET+ +PE+
Sbjct: 729 TGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEE 771
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 582 bits (1499), Expect = e-166
Identities = 286/440 (65%), Positives = 353/440 (80%), Gaps = 5/440 (1%)
Query: 10 ESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRREVTDKEQEF 69
E P+++ + + A + + KEE+ ++ + + E+ KE+E
Sbjct: 116 EPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREE 175
Query: 70 AARAAKQ--LEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVE 127
+ ++ LE + + +++ K ++ K+ KK K++QCKV LLDG+EY+CD+E
Sbjct: 176 KVKETQEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLE 235
Query: 128 KRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVK 187
K ++GQVLFDKVCEHLNLLEKDYFGL ++++ QKNWLDPAKEIK+Q+R+ W F+FNVK
Sbjct: 236 KHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVK 295
Query: 188 FYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGS 247
FYPPDP+QL+EDITRY+LCLQLR DI SGRLPCSFVT ALLGSYT+Q+ELGDYDP+E GS
Sbjct: 296 FYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGS 355
Query: 248 DYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSE 307
+SEF+FAP TKELE+KV ELHK+HRG++PA+A+ FLENAK+LSMYGVDLHHAKDSE
Sbjct: 356 IDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSE 415
Query: 308 GVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKL 367
GV+I LGVCA+GLLIY+DRLRINRFAWPK+LKISYKR+NFYIK+RP E EQFESTIGFKL
Sbjct: 416 GVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKL 475
Query: 368 PNHRAAKRLWKVCVEHHTFFRLLLPEAPPK-KFLTLGSKFRYSGRTQAQTRRASALIDRP 426
PNHRAAKRLWKVCVEHHTF+RL+ PE PPK KFLTLGSKFRYSGRTQAQTR+AS LIDRP
Sbjct: 476 PNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRP 535
Query: 427 APYFERSSSKRYTMSRSLDG 446
AP+FER+SSKR +SRSLDG
Sbjct: 536 APHFERTSSKR--VSRSLDG 553
Score = 115 bits (287), Expect = 3e-25
Identities = 74/148 (50%), Positives = 88/148 (59%), Gaps = 15/148 (10%)
Query: 944 PHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVL 1003
PHFE ++ K + S +P GV + K+ P E G L +
Sbjct: 537 PHFERTSSKRVSRSLDG-APIGVMDQSLMKDFPGAAGEISAY---------GPGLVSIAV 586
Query: 1004 MSAQTITSETTSTTTTTHIT----KTVKGGISETRIEKRIVITGDADIDHDQALAQAIKE 1059
+ E S T H+ KTVKGGISETRIEKRIVITGD DIDHDQALAQAI+E
Sbjct: 587 VQDGDGRREVRSPTKAPHLQLIEGKTVKGGISETRIEKRIVITGDGDIDHDQALAQAIRE 646
Query: 1060 AKEQHPDMSVTKVVVHKETEITPEDGED 1087
A+EQHPDMSVT+VVVHKETE+ E+GED
Sbjct: 647 AREQHPDMSVTRVVVHKETELA-EEGED 673
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 582 bits (1499), Expect = e-166
Identities = 286/440 (65%), Positives = 353/440 (80%), Gaps = 5/440 (1%)
Query: 10 ESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRREVTDKEQEF 69
E P+++ + + A + + KEE+ ++ + + E+ KE+E
Sbjct: 116 EPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREE 175
Query: 70 AARAAKQ--LEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVE 127
+ ++ LE + + +++ K ++ K+ KK K++QCKV LLDG+EY+CD+E
Sbjct: 176 KVKETQEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLE 235
Query: 128 KRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVK 187
K ++GQVLFDKVCEHLNLLEKDYFGL ++++ QKNWLDPAKEIK+Q+R+ W F+FNVK
Sbjct: 236 KHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVK 295
Query: 188 FYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGS 247
FYPPDP+QL+EDITRY+LCLQLR DI SGRLPCSFVT ALLGSYT+Q+ELGDYDP+E GS
Sbjct: 296 FYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGS 355
Query: 248 DYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSE 307
+SEF+FAP TKELE+KV ELHK+HRG++PA+A+ FLENAK+LSMYGVDLHHAKDSE
Sbjct: 356 IDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSE 415
Query: 308 GVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKL 367
GV+I LGVCA+GLLIY+DRLRINRFAWPK+LKISYKR+NFYIK+RP E EQFESTIGFKL
Sbjct: 416 GVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKL 475
Query: 368 PNHRAAKRLWKVCVEHHTFFRLLLPEAPPK-KFLTLGSKFRYSGRTQAQTRRASALIDRP 426
PNHRAAKRLWKVCVEHHTF+RL+ PE PPK KFLTLGSKFRYSGRTQAQTR+AS LIDRP
Sbjct: 476 PNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRP 535
Query: 427 APYFERSSSKRYTMSRSLDG 446
AP+FER+SSKR +SRSLDG
Sbjct: 536 APHFERTSSKR--VSRSLDG 553
Score = 115 bits (287), Expect = 3e-25
Identities = 74/148 (50%), Positives = 88/148 (59%), Gaps = 15/148 (10%)
Query: 944 PHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVL 1003
PHFE ++ K + S +P GV + K+ P E G L +
Sbjct: 537 PHFERTSSKRVSRSLDG-APIGVMDQSLMKDFPGAAGEISAY---------GPGLVSIAV 586
Query: 1004 MSAQTITSETTSTTTTTHIT----KTVKGGISETRIEKRIVITGDADIDHDQALAQAIKE 1059
+ E S T H+ KTVKGGISETRIEKRIVITGD DIDHDQALAQAI+E
Sbjct: 587 VQDGDGRREVRSPTKAPHLQLIEGKTVKGGISETRIEKRIVITGDGDIDHDQALAQAIRE 646
Query: 1060 AKEQHPDMSVTKVVVHKETEITPEDGED 1087
A+EQHPDMSVT+VVVHKETE+ E+GED
Sbjct: 647 AREQHPDMSVTRVVVHKETELA-EEGED 673
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 582 bits (1499), Expect = e-166
Identities = 286/440 (65%), Positives = 353/440 (80%), Gaps = 5/440 (1%)
Query: 10 ESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRREVTDKEQEF 69
E P+++ + + A + + KEE+ ++ + + E+ KE+E
Sbjct: 116 EPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREE 175
Query: 70 AARAAKQ--LEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVE 127
+ ++ LE + + +++ K ++ K+ KK K++QCKV LLDG+EY+CD+E
Sbjct: 176 KVKETQEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLE 235
Query: 128 KRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVK 187
K ++GQVLFDKVCEHLNLLEKDYFGL ++++ QKNWLDPAKEIK+Q+R+ W F+FNVK
Sbjct: 236 KHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVK 295
Query: 188 FYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGS 247
FYPPDP+QL+EDITRY+LCLQLR DI SGRLPCSFVT ALLGSYT+Q+ELGDYDP+E GS
Sbjct: 296 FYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGS 355
Query: 248 DYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSE 307
+SEF+FAP TKELE+KV ELHK+HRG++PA+A+ FLENAK+LSMYGVDLHHAKDSE
Sbjct: 356 IDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSE 415
Query: 308 GVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKL 367
GV+I LGVCA+GLLIY+DRLRINRFAWPK+LKISYKR+NFYIK+RP E EQFESTIGFKL
Sbjct: 416 GVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKL 475
Query: 368 PNHRAAKRLWKVCVEHHTFFRLLLPEAPPK-KFLTLGSKFRYSGRTQAQTRRASALIDRP 426
PNHRAAKRLWKVCVEHHTF+RL+ PE PPK KFLTLGSKFRYSGRTQAQTR+AS LIDRP
Sbjct: 476 PNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRP 535
Query: 427 APYFERSSSKRYTMSRSLDG 446
AP+FER+SSKR +SRSLDG
Sbjct: 536 APHFERTSSKR--VSRSLDG 553
Score = 240 bits (612), Expect = 6e-63
Identities = 169/401 (42%), Positives = 229/401 (57%), Gaps = 49/401 (12%)
Query: 714 AELKAQELEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLSTSPVRLAAR---Q 770
+ L +EL+K Q+D++KHQ +ISELKR F+E ST NEWEKR T P+ L +
Sbjct: 627 SNLMLEELDKAQEDILKHQASISELKRNFME-STPEPRPNEWEKRRIT-PLSLQTQGSSH 684
Query: 771 EDAPMIEPLVPEE--------TKQSSGEKLMDGS---EIFSLLESARKPTEFIGGVTSTS 819
E ++E E T++ +G+++ GS EI + +K + + +S+S
Sbjct: 685 ETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGPGEIRKVEPVTQKDSTSLSSESSSS 744
Query: 820 QSWVQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGD 879
S E++ E G E HH +V + T+ E+ + +A
Sbjct: 745 SS-----ESEEEDVG---EYRPHH------RVTEGTIREEQEYEEEVEEEPRPAAKVVER 790
Query: 880 AAAQPAFTGIKGKEGSALTE--------GAKEEGGEE-VAKAVLEQEETAAASRERQEEQ 930
A P + + S +T GA++ GE+ V + L+Q+ A E Q+
Sbjct: 791 EEAVPEASPVTQAGASVITVETVIQENVGAQKIPGEKSVHEGALKQDMGEEAEEEPQKVN 850
Query: 931 SAAIHISETLEQKPHF----ESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTIT 986
H+ ++ P E VKTE ++ +S + EISTKEVP+V TETKTIT
Sbjct: 851 GEVSHVD--IDVLPQIICCSEPPVVKTEMVT---ISDASQRTEISTKEVPIVQTETKTIT 905
Query: 987 YESSQVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDAD 1046
YES Q+D G + G L++AQTITSE+ STTTTTHITKTVKGGISETRIEKRIVITGD D
Sbjct: 906 YESPQIDGGAGGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVITGDGD 965
Query: 1047 IDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPEDGED 1087
IDHDQALAQAI+EA+EQHPDMSVT+VVVHKETE+ E+GED
Sbjct: 966 IDHDQALAQAIREAREQHPDMSVTRVVVHKETELA-EEGED 1005
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 525 bits (1352), Expect = e-149
Identities = 266/401 (66%), Positives = 313/401 (78%), Gaps = 19/401 (4%)
Query: 110 MQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAK 169
M CKV LLD + Y C VEK ++GQ L +VCEHLNLLE+DYFGL D K WLD AK
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 170 EIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLG 229
EIKKQVR W+F+FNVKFYPPDPAQL+EDITRYYLCLQLR DIV+GRLPCSF TLALLG
Sbjct: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
Query: 230 SYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLEN 289
SYT+QSELGDYDP+ G DY+S+F+ APN TKELE+KV+ELHKS+R MTPA+A++ FLEN
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
Query: 290 AKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYI 349
AKKLSMYGVDLH AKD EGV+I+LGVC+SGLL+Y+D+LRINRF WPKVLKISYKR++F+I
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
Query: 350 KIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPK-KFLTLGSKFRY 408
KIRPGE EQ+ESTIGFKLP++RAAK+LWKVCVEHHTFFRL + PK KFL LGSKFRY
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
Query: 409 SGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVG----------TGQYATTK- 457
SGRTQAQTR+ASALIDRPAP+FER++SKR SRSLDG T A T+
Sbjct: 301 SGRTQAQTRQASALIDRPAPHFERTASKR--ASRSLDGAAAVDSADRSPRPTSAPAITQG 358
Query: 458 -----GISQTNLITTVTPEKKAEEERDEEEDKRRKGEEVTP 493
G+ + TV P+ + E + E + + E+ P
Sbjct: 359 QVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEP 399
Score = 195 bits (495), Expect = 2e-49
Identities = 102/134 (76%), Positives = 116/134 (86%), Gaps = 2/134 (1%)
Query: 951 VKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGT-DLEPGVLMSAQTI 1009
VKT+T++ S + VK EI TK+VP+VHTETKTITYE++Q D + DL+PGVL++AQTI
Sbjct: 509 VKTQTVTI-SDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTI 567
Query: 1010 TSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSV 1069
TSET S+TTTT ITKTVKGGISETRIEKRIVITGDADIDHDQ L QAIKEAKEQHPDMSV
Sbjct: 568 TSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSV 627
Query: 1070 TKVVVHKETEITPE 1083
TKVVVH+ETEI E
Sbjct: 628 TKVVVHQETEIADE 641
Score = 51.2 bits (121), Expect = 5e-06
Identities = 40/121 (33%), Positives = 62/121 (51%), Gaps = 11/121 (9%)
Query: 688 EETDSERTDTAADGETTATESDQEED-------AELKAQELEKTQDDLMKHQTNISELKR 740
E+T E T ++G+ T + ++ + + L ++L+K+Q+++ KH +ISELK+
Sbjct: 408 EKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKK 467
Query: 741 TFLETSTDTAVTNEWEKRLST-SPVRLAARQEDAPMIE--PLVPEETKQSSGEKLMDGSE 797
F+E S +EW+KRLST SP R P E PLV +T S SE
Sbjct: 468 NFME-SVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSE 526
Query: 798 I 798
I
Sbjct: 527 I 527
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 525 bits (1352), Expect = e-149
Identities = 266/401 (66%), Positives = 313/401 (78%), Gaps = 19/401 (4%)
Query: 110 MQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAK 169
M CKV LLD + Y C VEK ++GQ L +VCEHLNLLE+DYFGL D K WLD AK
Sbjct: 1 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAK 60
Query: 170 EIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLG 229
EIKKQVR W+F+FNVKFYPPDPAQL+EDITRYYLCLQLR DIV+GRLPCSF TLALLG
Sbjct: 61 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 120
Query: 230 SYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLEN 289
SYT+QSELGDYDP+ G DY+S+F+ APN TKELE+KV+ELHKS+R MTPA+A++ FLEN
Sbjct: 121 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 180
Query: 290 AKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYI 349
AKKLSMYGVDLH AKD EGV+I+LGVC+SGLL+Y+D+LRINRF WPKVLKISYKR++F+I
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
Query: 350 KIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPK-KFLTLGSKFRY 408
KIRPGE EQ+ESTIGFKLP++RAAK+LWKVCVEHHTFFRL + PK KFL LGSKFRY
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 300
Query: 409 SGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVG----------TGQYATTK- 457
SGRTQAQTR+ASALIDRPAP+FER++SKR SRSLDG T A T+
Sbjct: 301 SGRTQAQTRQASALIDRPAPHFERTASKR--ASRSLDGAAAVDSADRSPRPTSAPAITQG 358
Query: 458 -----GISQTNLITTVTPEKKAEEERDEEEDKRRKGEEVTP 493
G+ + TV P+ + E + E + + E+ P
Sbjct: 359 QVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEP 399
Score = 137 bits (346), Expect = 4e-32
Identities = 79/133 (59%), Positives = 88/133 (66%), Gaps = 34/133 (25%)
Query: 951 VKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVLMSAQTIT 1010
VKT+T++ S + VK EI TK+VP+VHTETKTITYE++Q
Sbjct: 490 VKTQTVTI-SDNANAVKSEIPTKDVPIVHTETKTITYEAAQ------------------- 529
Query: 1011 SETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVT 1070
TVKGGISETRIEKRIVITGDADIDHDQ L QAIKEAKEQHPDMSVT
Sbjct: 530 --------------TVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVT 575
Query: 1071 KVVVHKETEITPE 1083
KVVVH+ETEI E
Sbjct: 576 KVVVHQETEIADE 588
Score = 53.9 bits (128), Expect = 8e-07
Identities = 59/214 (27%), Positives = 92/214 (42%), Gaps = 23/214 (10%)
Query: 669 PKAASLSASLDNDPSDSSEEETDSERTDT-AADGETTATESDQEEDAELKAQELEKTQDD 727
PKA + + D E+ + E T+ E E+ + L ++L+K+Q++
Sbjct: 376 PKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEE 435
Query: 728 LMKHQTNISELKRTFLETSTDTAVTNEWEKRLST-SPVRLAARQEDAPMIE--PLVPEET 784
+ KH +ISELK+ F+E S +EW+KRLST SP R P E PLV +T
Sbjct: 436 IKKHHASISELKKNFME-SVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQT 494
Query: 785 KQSSGEKLMDGSEI----FSLLESARKPTEFIGGVT---STSQSWVQKMETKTESSGIE- 836
S SEI ++ + K + T S++ ++K T + I+
Sbjct: 495 VTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIVITGDADIDH 554
Query: 837 --------TEPTVHHLPLSTEKVV--QETVLVEE 860
E H +S KVV QET + +E
Sbjct: 555 DQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 588
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 486 bits (1250), Expect = e-137
Identities = 282/566 (49%), Positives = 363/566 (64%), Gaps = 66/566 (11%)
Query: 31 APVPEP-PKEEQQQALEQFAAAAAHSTPVRREVTDKEQEFAARAAKQLEY-QQLEDDKLS 88
AP+ P P+ + +L+ + ++A + P + E+ + + +F + + LE ++E + S
Sbjct: 130 APIAAPEPELKTDPSLDLHSLSSAETQPAQEELRE-DPDFEIKEGEGLEECSKIEVKEES 188
Query: 89 QKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEK 148
+S + ++ K ++K ++M CKV LLD + Y C VE
Sbjct: 189 PQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVE--------------------- 227
Query: 149 DYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQ 208
WLD AKEIKKQVR W+F+FNVKFYPPDPAQL+EDITRYYLCLQ
Sbjct: 228 --------------TWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQ 273
Query: 209 LRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVI 268
LR DIV+GRLPCSF TLALLGSYT+QSELGDYDP+ G DY+S+F+ APN TKELE+KV+
Sbjct: 274 LRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVM 333
Query: 269 ELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLR 328
ELHKS+R MTPA+A++ FLENAKKLSMYGVDLH AKD EGV+I+LGVC+SGLL+Y+D+LR
Sbjct: 334 ELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLR 393
Query: 329 INRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFR 388
INRF WPKVLKISYKR++F+IKIRPGE EQ+ESTIGFKLP++RAAK+LWKVCVEHHTFFR
Sbjct: 394 INRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFR 453
Query: 389 LLLPEAPPK-KFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGE 447
L + PK KFL LGSKFRYSGRTQAQTR+ASALIDRPAP+FER++SKR SRSLDG
Sbjct: 454 LTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKR--ASRSLDGA 511
Query: 448 VG----------TGQYATTK------GISQTNLITTVTPEKKAEEERDE--EEDKRRKGE 489
T A T+ G+ + TV P+ + E + E +ED+ +
Sbjct: 512 AAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQA 571
Query: 490 EVTPISAIRHEGKS-PGLGTDSCPLSPPSTHCAPTSPTELRRRCKENDCKLPGYEPSRAE 548
E P A + KS + +S + + P R E D +L + P R
Sbjct: 572 EPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVP---EPRPSEWDKRLSTHSPFRTL 628
Query: 549 HLPGEPALDSDGPGRPYLGDQDVAFS 574
++ G+ G G P + Q V S
Sbjct: 629 NINGQ---IPTGEGPPLVKTQTVTIS 651
Score = 195 bits (495), Expect = 2e-49
Identities = 102/134 (76%), Positives = 116/134 (86%), Gaps = 2/134 (1%)
Query: 951 VKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGT-DLEPGVLMSAQTI 1009
VKT+T++ S + VK EI TK+VP+VHTETKTITYE++Q D + DL+PGVL++AQTI
Sbjct: 643 VKTQTVTI-SDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTI 701
Query: 1010 TSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSV 1069
TSET S+TTTT ITKTVKGGISETRIEKRIVITGDADIDHDQ L QAIKEAKEQHPDMSV
Sbjct: 702 TSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSV 761
Query: 1070 TKVVVHKETEITPE 1083
TKVVVH+ETEI E
Sbjct: 762 TKVVVHQETEIADE 775
Score = 50.1 bits (118), Expect = 1e-05
Identities = 43/142 (30%), Positives = 67/142 (47%), Gaps = 13/142 (9%)
Query: 669 PKAASLSASLDNDPSDSSEEETDSERTDTA-ADGETTATESDQEEDAELKAQ-------- 719
P+ S A ++ + +++T A ET E +E++ +A+
Sbjct: 521 PRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWK 580
Query: 720 ELEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLST-SPVRLAARQEDAPMIE- 777
+L+K+Q+++ KH +ISELK+ F+E S +EW+KRLST SP R P E
Sbjct: 581 DLDKSQEEIKKHHASISELKKNFME-SVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEG 639
Query: 778 -PLVPEETKQSSGEKLMDGSEI 798
PLV +T S SEI
Sbjct: 640 PPLVKTQTVTISDNANAVKSEI 661
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 308 bits (790), Expect = 1e-83
Identities = 163/367 (44%), Positives = 228/367 (62%), Gaps = 12/367 (3%)
Query: 112 CKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRD-AENQKNWLDPAKE 170
C ++LLD + V K +GQVL D V +HL+L E+DYFGL D + + WLDP K
Sbjct: 31 CNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKP 90
Query: 171 IKKQVRSGA-WHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLG 229
I+KQ++ G+ + +F VKF+ DP +L E+ TRY LQ++ DI++GRLPC T ALL
Sbjct: 91 IRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLA 150
Query: 230 SYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLEN 289
S+ VQSELGDYD E S Y+S++ F PN ++ E ++ +LH+ H G++PAEAE ++L
Sbjct: 151 SFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLNT 210
Query: 290 AKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYI 349
A+ L +YGV+ H+A+D EIM+GV + G+LIY++R+R+N F W K++KIS+K F+I
Sbjct: 211 ARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFI 270
Query: 350 KIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKF----LTLGSK 405
++R E E+ +GF + N+RA K LWK CVEHHTFFRL P P K F TLGSK
Sbjct: 271 QLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSK 330
Query: 406 FRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYATTKGISQTNLI 465
FRY GRT+ Q+ + F RS SK + +D EV + IS L
Sbjct: 331 FRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLA-RKLMDWEV-----VSRNSISDDRLE 384
Query: 466 TTVTPEK 472
T P +
Sbjct: 385 TQSLPSR 391
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 278 bits (712), Expect = 2e-74
Identities = 143/334 (42%), Positives = 210/334 (62%), Gaps = 8/334 (2%)
Query: 112 CKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEI 171
C+V LLDG++ + D+ K+++GQ LFD++ HL+L+E DYFGL + D+ +WLD K I
Sbjct: 45 CRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSI 104
Query: 172 KKQVRSGA-WHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGS 230
KKQV+ G+ + VKFY +P L E++TRY LQL+ DI+SG+L C F T L +
Sbjct: 105 KKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQLAA 164
Query: 231 YTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENA 290
Y +Q+ELGDYD E + +SEFRF P T+E+E + E K +RG TPA+AE ++L A
Sbjct: 165 YNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLNKA 224
Query: 291 KKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIK 350
K L MYGVD+H K +G + LG+ +G+L++ +I F WPK+ ++ +K+N +
Sbjct: 225 KWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKLTLV 284
Query: 351 I--RPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLP---EAPPKKFLTLGSK 405
+ + ++ E T F+L + +A K LWK VEHH FFRL P + F+ LGS+
Sbjct: 285 VVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSHRSGFIRLGSR 344
Query: 406 FRYSGRTQAQTRRASALIDRPAPYFERSSSKRYT 439
FRYSG+T+ QT + + R + FER SKRY+
Sbjct: 345 FRYSGKTEYQTTKTNKA--RRSTSFERRPSKRYS 376
>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
1 [Homo sapiens]
Length = 518
Score = 269 bits (687), Expect = 1e-71
Identities = 142/340 (41%), Positives = 207/340 (60%), Gaps = 8/340 (2%)
Query: 109 SMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPA 168
++ C+V LLDG+E + D+ K ++GQ LFD++ HL+L+E DYFGL + D+ +WLD A
Sbjct: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
Query: 169 KEIKKQVRSG-AWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLAL 227
K IKKQ++ G A+ F VK+Y +P L E+ TRY LQLR DI+SG+L C + T
Sbjct: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203
Query: 228 LGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFL 287
L + +Q+ELG+ + E + +SEFRF PN T+ +E + + K RG +PA+AE+ +L
Sbjct: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263
Query: 288 ENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNF 347
AK L MYGVD+H + +G E LG+ +G+LI+ +I F WPK+ K+ +K++
Sbjct: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323
Query: 348 YIKIRPGEFE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLP---EAPPKKFLTL 402
+ + + + + E T F+L + R K LWK VEHH FFRL P ++ F+ L
Sbjct: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383
Query: 403 GSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSR 442
GS+FR+SGRT+ Q S L R FER SKRY R
Sbjct: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421
>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
2 [Homo sapiens]
Length = 900
Score = 269 bits (687), Expect = 1e-71
Identities = 142/340 (41%), Positives = 207/340 (60%), Gaps = 8/340 (2%)
Query: 109 SMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPA 168
++ C+V LLDG+E + D+ K ++GQ LFD++ HL+L+E DYFGL + D+ +WLD A
Sbjct: 84 TLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHA 143
Query: 169 KEIKKQVRSG-AWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLAL 227
K IKKQ++ G A+ F VK+Y +P L E+ TRY LQLR DI+SG+L C + T
Sbjct: 144 KPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203
Query: 228 LGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFL 287
L + +Q+ELG+ + E + +SEFRF PN T+ +E + + K RG +PA+AE+ +L
Sbjct: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYL 263
Query: 288 ENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNF 347
AK L MYGVD+H + +G E LG+ +G+LI+ +I F WPK+ K+ +K++
Sbjct: 264 NKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKL 323
Query: 348 YIKIRPGEFE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLP---EAPPKKFLTL 402
+ + + + + E T F+L + R K LWK VEHH FFRL P ++ F+ L
Sbjct: 324 TLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRL 383
Query: 403 GSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSR 442
GS+FR+SGRT+ Q S L R FER SKRY R
Sbjct: 384 GSRFRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 268 bits (684), Expect = 3e-71
Identities = 161/423 (38%), Positives = 237/423 (56%), Gaps = 14/423 (3%)
Query: 108 KSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDP 167
K + K+ +LD ++ +V +R+ G+VL D VC HLNL+E DYFGL + D + WLD
Sbjct: 38 KLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDL 97
Query: 168 AKEIKKQVRSGAWHF-SFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLA 226
K I KQ+R F VKF+PPD QL E++TRY LQ++ D+ GRL C+ + A
Sbjct: 98 LKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAA 157
Query: 227 LLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHF 286
LL S+ VQSE+GD+D + +++++ ++ P LEDK++E H +H G TPAE++
Sbjct: 158 LLISHIVQSEIGDFD-EALDREHLAKNKYIPQQDA-LEDKIVEFHHNHIGQTPAESDFQL 215
Query: 287 LENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNN 346
LE A++L MYG+ LH AKD EG +I L V +G+L+++ +IN F W KV K+S+KR
Sbjct: 216 LEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKR 275
Query: 347 FYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLL-LPEAPPKKFL-TLGS 404
F IK+RP ++ T+ F + + K WK+CVEHH FFRL P+ PK L + GS
Sbjct: 276 FLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGS 335
Query: 405 KFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYATTKGISQTNL 464
FR+SGRTQ Q FER SK +++ RSL + ++ + Q+
Sbjct: 336 SFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSI-RSLASQ---PTELNSEVLEQSQQ 391
Query: 465 ITTVTPEKKAEEERDEEEDKRRKGEEVTPISAIRHEGKSPGLGTDSCPLSPPSTHCAPTS 524
T++T + AE + R+G+E P + G P P A ++
Sbjct: 392 STSLTFGEGAESPGGQ---SCRRGKE--PKVSAGEPGSHPSPAPRRSPAGNKQADGAASA 446
Query: 525 PTE 527
PTE
Sbjct: 447 PTE 449
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 263 bits (672), Expect = 7e-70
Identities = 140/347 (40%), Positives = 208/347 (59%), Gaps = 17/347 (4%)
Query: 107 PKSMQCKVILLDGSEYTCD-----VEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQ 161
P+ C+V+LLD S+ T ++K ++G V+ D V H+NL+E DYFGL Y D +Q
Sbjct: 8 PEEFYCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQ 67
Query: 162 KNWLDPAK---EIKKQVRSGA-WHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGR 217
WLDPAK E K+ + +G + F +KFY DP +L E+ITRY LQ++ D++ GR
Sbjct: 68 TYWLDPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGR 127
Query: 218 LPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGM 277
LPC T A LG+Y +QSELGDYDP + + Y+SE+RF P+ +ELE+ + +HK+ G
Sbjct: 128 LPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQ 187
Query: 278 TPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKV 337
P+EAE+++L AK L MYGVDLH E LG+ G+++Y+++ ++ ++ WP++
Sbjct: 188 IPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRI 247
Query: 338 LKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPP- 396
K+ +K F +++ + E++ F+ + A K LWK VEHHTFFR+ E+
Sbjct: 248 TKVHFKETQFELRVLGKDCN--ETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSL 305
Query: 397 ----KKFLTLGSKFRYSGRTQAQ-TRRASALIDRPAPYFERSSSKRY 438
KF ++ K RYSGRT Q +R S + RP RS SK Y
Sbjct: 306 SRKLSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTY 352
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 261 bits (667), Expect = 3e-69
Identities = 136/347 (39%), Positives = 204/347 (58%), Gaps = 9/347 (2%)
Query: 108 KSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDP 167
+ M+C + LLD SE +C +++ ++GQ L D +C + +LLEKDYFG+ Y D E Q++WL+P
Sbjct: 30 QEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEP 89
Query: 168 AKEIKKQVRSGA-WHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLA 226
K I KQ+++ + F VKFYP +P ++ E++TRY L LQ++ DI GRL CSF A
Sbjct: 90 NKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAA 149
Query: 227 LLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSH-RGMTPAEAEMH 285
LG+ VQ+ELGDYDPDE +YISEF P +++LE K++E+HK+ RG +P AE +
Sbjct: 150 YLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFN 209
Query: 286 FLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRN 345
L A L YGVD H KDS G LG A+G ++++ RI+ WP V K+ ++
Sbjct: 210 LLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGK 269
Query: 346 NFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLL----LPEAPPKKFLT 401
FY+ G ++ ++ + F A K LWK VE+ F++ + K
Sbjct: 270 TFYV---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFF 326
Query: 402 LGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEV 448
GS+FRYSG+ + AS+ I R P R++ + S SL+ ++
Sbjct: 327 KGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQL 373
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 257 bits (657), Expect = 4e-68
Identities = 161/443 (36%), Positives = 234/443 (52%), Gaps = 32/443 (7%)
Query: 108 KSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDP 167
K + +V LLD + D+E + GQVL +V + LNL+E DYFG+ +++ ++ WL+P
Sbjct: 42 KHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEP 101
Query: 168 AKEIKKQVRSGA-WHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLA 226
K I +Q+R VKF+PPDP QL E+ TRY LQL+ D++ RL C+ T A
Sbjct: 102 MKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAA 161
Query: 227 LLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHF 286
LL S+ +QSE+GDYD + +++ + P LE K++E H+ H G TPAE++
Sbjct: 162 LLTSHLLQSEIGDYD-ETLDREHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAESDFQV 219
Query: 287 LENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNN 346
LE A+KL MYG+ H A D EG +I L V G+L+++ +IN F W KV K+S+KR
Sbjct: 220 LEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKR 279
Query: 347 FYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKK--FLTLGS 404
F IK+ P ++ T+ F L + K WK+CVE+HTFFRLL P K F + GS
Sbjct: 280 FLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGS 339
Query: 405 KFRYSGRTQAQTRRASALID-------RPAPYFERSSSKRYTMSRSLDGEVGTGQYATTK 457
FRYSGRTQ Q L+D + PY ER SK +T R+L ++ + +
Sbjct: 340 SFRYSGRTQKQ------LVDYFKDSGMKRIPY-ERRHSKTHTSVRALTADLPKQSISFPE 392
Query: 458 GI------SQTNLITTVTPEKKAEEERDEEEDKRRKGEE------VTPISAIRHEGKSPG 505
G+ S N +++P E +D + +P + R + G
Sbjct: 393 GLRTPASPSSANAFYSLSPSTLVPSGLPEFKDSSSSLTDPQVSYVKSPAAERRSGAVAGG 452
Query: 506 LGTDSC-PLSPPSTHCAPTSPTE 527
T S PL PP+ P T+
Sbjct: 453 PDTPSAQPLGPPALQPGPGLSTK 475
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 248 bits (633), Expect = 2e-65
Identities = 129/332 (38%), Positives = 192/332 (57%), Gaps = 8/332 (2%)
Query: 108 KSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDP 167
+ C V LLD SEYTC +++ ++GQ LFD +C HLNLLEKDYFG+ + D + Q++WL+
Sbjct: 15 REYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEF 74
Query: 168 AKEIKKQVRSGA-WHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLA 226
K + KQ+RS + F VKFYP DPA L E+ITRY + LQ++ D+ GRL C A
Sbjct: 75 TKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAA 134
Query: 227 LLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSH-RGMTPAEAEMH 285
LL +Y +Q+E+GDYD + Y S+F+F P H+++LE K+ E+HK+ G TPA +E++
Sbjct: 135 LLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELN 194
Query: 286 FLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRN 345
FL A+ L YGVD H KD G L G ++ + R++ W +V K+ ++
Sbjct: 195 FLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGK 254
Query: 346 NFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRL----LLPEAPPKKFLT 401
FY+ + + E+ + + + P A K LWK +E+ F++L +
Sbjct: 255 TFYLYV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFF 312
Query: 402 LGSKFRYSGRTQAQTRRASALIDRPAPYFERS 433
GS+FRYSGR + +SA I R P R+
Sbjct: 313 KGSRFRYSGRVAKEVMESSAKIKREPPEIHRA 344
>gi|34916000 FERM domain containing 7 [Homo sapiens]
Length = 714
Score = 243 bits (620), Expect = 7e-64
Identities = 163/488 (33%), Positives = 244/488 (50%), Gaps = 30/488 (6%)
Query: 110 MQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAK 169
+ KV LD S+ V+++S G+ LF+ C HLNL EK+YFGL + WL+ K
Sbjct: 2 LHLKVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLK 61
Query: 170 EIKKQVRSGAWH-FSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALL 228
I KQV++ F F VKF+P DP L E++TRY LQ++ D+ GRLPCS AL+
Sbjct: 62 PITKQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALM 121
Query: 229 GSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLE 288
S+ +QSELGD+ +E ++++ R+ PN LE K++ H+ H G +PAE+++ L+
Sbjct: 122 VSHILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLD 179
Query: 289 NAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFY 348
A+KL MYG+ H A D EG++I L V G+L+ R +IN F W K+ K+S+KR +F
Sbjct: 180 IARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFL 239
Query: 349 IKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLL-LPEAPPKKFL-TLGSKF 406
IK+ + T+ F + + A K WK CVE+H FFRL P++ PK L + GS F
Sbjct: 240 IKLHANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSF 299
Query: 407 RYSGRTQAQT-------RRASALIDR---PAPYFERSSSKRYTMSRSLDGEV-------G 449
RYSGRTQ Q R S +R P+ Y ER + + +V G
Sbjct: 300 RYSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYG 359
Query: 450 TGQYATTKGISQTNLITTVTPEKKAEEERDEEEDKRRKGE-EVTPISAIRHEGKSPGLGT 508
G Y G+ + + A E E + K E + T + + P +
Sbjct: 360 GGYYQNVNGVHASEPVLESRRRNSALEVTFATELEHSKPEADPTLLHQSQSSSSFPFIYM 419
Query: 509 DSCPLSPPSTHCAP-------TSPTELRRRCKENDCKLPGYEPSRAEHLPGEPALDSDGP 561
D + P+ + P +S + + CK + + Y ++ P + +D P
Sbjct: 420 DPVFNTEPNPNPDPRDIFSERSSLSSFQTSCKFSGNHMSIYSGLTSKVRPAKQLTYTDVP 479
Query: 562 GRPYLGDQ 569
P G Q
Sbjct: 480 YIPCTGQQ 487
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 224 bits (570), Expect = 4e-58
Identities = 132/398 (33%), Positives = 210/398 (52%), Gaps = 17/398 (4%)
Query: 94 SKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGL 153
+ + S L K + C + LDG T V K+ GQVL D V HL + EK+YFGL
Sbjct: 13 NNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGL 72
Query: 154 TYRD-AENQKNWLDPAKEIKKQVRSG-AWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRD 211
+ D + + WL+ +K I+KQ++ G F V+F+ PDP L ++ TR+ LQL+
Sbjct: 73 QHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKM 132
Query: 212 DIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELH 271
DI GRL C + +L SY VQS GDY+ Y+S+ F P+ ++ KV LH
Sbjct: 133 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 192
Query: 272 KSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINR 331
+ H G+ +EAE ++ A+ L YGV+LH +D +++M+G+ ++G+ +YR + +
Sbjct: 193 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 252
Query: 332 FAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFF--RL 389
+ W +LKIS+KR F+I R + E E + F + N+R+ K LWK CVEHHTFF +
Sbjct: 253 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312
Query: 390 LLPEAPP--KKFLTLGSK--FRYSGRTQAQTRR----ASALIDRPAPYFERSSSKRYTMS 441
LLP+ ++ T+GS+ + S R + + R+ ++ + Y + YT
Sbjct: 313 LLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYK 372
Query: 442 RSL-----DGEVGTGQYATTKGISQTNLITTVTPEKKA 474
SL D EV + + +S+ N + +K +
Sbjct: 373 GSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSS 410
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 223 bits (568), Expect = 8e-58
Identities = 127/358 (35%), Positives = 197/358 (55%), Gaps = 9/358 (2%)
Query: 94 SKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGL 153
+ + S L K + C + LDG T V K+ GQVL D V HL + EK+YFGL
Sbjct: 13 NNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGL 72
Query: 154 TYRD-AENQKNWLDPAKEIKKQVRSG-AWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRD 211
+ D + + WL+ +K I+KQ++ G F V+F+ PDP L ++ TR+ LQL+
Sbjct: 73 QHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKM 132
Query: 212 DIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELH 271
DI GRL C + +L SY VQS GDY+ Y+S+ F P+ ++ KV LH
Sbjct: 133 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 192
Query: 272 KSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINR 331
+ H G+ +EAE ++ A+ L YGV+LH +D +++M+G+ ++G+ +YR + +
Sbjct: 193 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 252
Query: 332 FAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFF--RL 389
+ W +LKIS+KR F+I R + E E + F + N+R+ K LWK CVEHHTFF +
Sbjct: 253 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312
Query: 390 LLPEAPP--KKFLTLGSK-FRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSL 444
LLP+ ++ T+GS+ + S Q + ++ PA RS S + ++SL
Sbjct: 313 LLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPA--MRRSLSVEHLETKSL 368
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 164 bits (415), Expect = 4e-40
Identities = 101/307 (32%), Positives = 162/307 (52%), Gaps = 20/307 (6%)
Query: 95 KLSRSPLKIVKKPKSMQCKVILLDGS--EYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFG 152
KL R+ V + ++ LL+ E+T VE S GQ + V + L L E YF
Sbjct: 8 KLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVE--STGQESLEAVAQRLELREVTYFS 65
Query: 153 LTYRDAENQKNWLDPAKEIKKQVRSGAWHFS--FNVKFYPPDPAQLSEDITRYYLCLQLR 210
L Y + +NQ+ W+D K +KKQ+ A + F V FY P +QL ++ITRY LQL+
Sbjct: 66 LWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLK 125
Query: 211 DDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAP----NHTKELED- 265
DI+ G +PC+ L VQ++ GD+D E D++ +F P K LE+
Sbjct: 126 KDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYE-SQDFLQKFALFPVGWLQDEKVLEEA 184
Query: 266 --KVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLI- 322
KV LH+ +RG+T +AEM +++ +++ YG + + AKDS+G +I +G C G+ +
Sbjct: 185 TQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVK 244
Query: 323 YRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVE 382
+++ F W + +S+ ++ F + E E TI F+ + AK +W++CV
Sbjct: 245 HKNGRHPVVFRWHDIANMSHNKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLCVA 299
Query: 383 HHTFFRL 389
H F+RL
Sbjct: 300 RHKFYRL 306
>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
Length = 737
Score = 153 bits (386), Expect = 1e-36
Identities = 88/278 (31%), Positives = 145/278 (52%), Gaps = 15/278 (5%)
Query: 212 DIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELH 271
DI GRL C + +L SY VQS GDY+ Y+S+ F P+ ++ KV LH
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 272 KSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINR 331
+ H G+ +EAE ++ A+ L YGV+LH +D +++M+G+ ++G+ +YR + +
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 332 FAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFF--RL 389
+ W +LKIS+KR F+I R + E E + F + N+R+ K LWK CVEHHTFF +
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
Query: 390 LLPEAPP--KKFLTLGSK--FRYSGRTQAQTRR----ASALIDRPAPYFERSSSKRYTMS 441
LLP+ ++ T+GS+ + S R + + R+ ++ + Y + YT
Sbjct: 182 LLPQEKNVLSQYWTMGSRNTKKRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYK 241
Query: 442 RSL-----DGEVGTGQYATTKGISQTNLITTVTPEKKA 474
SL D EV + + +S+ N + +K +
Sbjct: 242 GSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSS 279
>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
isoform 3 [Homo sapiens]
Length = 782
Score = 152 bits (384), Expect = 2e-36
Identities = 83/238 (34%), Positives = 132/238 (55%), Gaps = 7/238 (2%)
Query: 212 DIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELH 271
DI GRL C + +L SY VQS GDY+ Y+S+ F P+ ++ KV LH
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 272 KSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINR 331
+ H G+ +EAE ++ A+ L YGV+LH +D +++M+G+ ++G+ +YR + +
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 332 FAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFF--RL 389
+ W +LKIS+KR F+I R + E E + F + N+R+ K LWK CVEHHTFF +
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
Query: 390 LLPEAPP--KKFLTLGSK-FRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSL 444
LLP+ ++ T+GS+ + S Q + ++ PA RS S + ++SL
Sbjct: 182 LLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPA--MRRSLSVEHLETKSL 237
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 146 bits (368), Expect = 1e-34
Identities = 118/415 (28%), Positives = 186/415 (44%), Gaps = 46/415 (11%)
Query: 107 PKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLD 166
PK + +V +D +E ++ + G+ LFD+V + + L E YFGL Y D + WL
Sbjct: 2 PKPINVRVTTMD-AELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK 60
Query: 167 PAKEIKKQV--RSGAWHFSFNVKFYPPDPAQ-LSEDITRYYLCLQLRDDIVSGRLPCSFV 223
K++ Q + F F KFYP D A+ L +DIT+ LQ+++ I+S + C
Sbjct: 61 LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE 120
Query: 224 TLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKEL--------EDKVIELHKSHR 275
T LLGSY VQ++ GDY+ + S Y+S R P + ED++ H HR
Sbjct: 121 TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR 180
Query: 276 GMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRIN---RF 332
GM A + +L+ A+ L MYG++ K+ +G ++ LGV A GL IY ++ F
Sbjct: 181 GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF 240
Query: 333 AWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCV-EHHTFFRLLL 391
W ++ IS+ F IK ++ F P R KR+ ++C+ H + R
Sbjct: 241 PWSEIRNISFNDKKFVIK----PIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRK 296
Query: 392 PEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTG 451
P+ + + + QA+ + ++R E +R T+ R +
Sbjct: 297 PDTIEVQQM----------KAQAREEKHQKQLER--QQLETEKKRRETVEREKE------ 338
Query: 452 QYATTKGISQTNLITTVTPEKKAEEERDE--------EEDKRRKGEEVTPISAIR 498
Q K L KKAE E E EE+++R EE + A R
Sbjct: 339 QMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADR 393
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 146 bits (368), Expect = 1e-34
Identities = 118/415 (28%), Positives = 186/415 (44%), Gaps = 46/415 (11%)
Query: 107 PKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLD 166
PK + +V +D +E ++ + G+ LFD+V + + L E YFGL Y D + WL
Sbjct: 2 PKPINVRVTTMD-AELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK 60
Query: 167 PAKEIKKQV--RSGAWHFSFNVKFYPPDPAQ-LSEDITRYYLCLQLRDDIVSGRLPCSFV 223
K++ Q + F F KFYP D A+ L +DIT+ LQ+++ I+S + C
Sbjct: 61 LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE 120
Query: 224 TLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKEL--------EDKVIELHKSHR 275
T LLGSY VQ++ GDY+ + S Y+S R P + ED++ H HR
Sbjct: 121 TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR 180
Query: 276 GMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRIN---RF 332
GM A + +L+ A+ L MYG++ K+ +G ++ LGV A GL IY ++ F
Sbjct: 181 GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF 240
Query: 333 AWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCV-EHHTFFRLLL 391
W ++ IS+ F IK ++ F P R KR+ ++C+ H + R
Sbjct: 241 PWSEIRNISFNDKKFVIK----PIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRK 296
Query: 392 PEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTG 451
P+ + + + QA+ + ++R E +R T+ R +
Sbjct: 297 PDTIEVQQM----------KAQAREEKHQKQLER--QQLETEKKRRETVEREKE------ 338
Query: 452 QYATTKGISQTNLITTVTPEKKAEEERDE--------EEDKRRKGEEVTPISAIR 498
Q K L KKAE E E EE+++R EE + A R
Sbjct: 339 QMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADR 393
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 138 bits (347), Expect = 3e-32
Identities = 110/418 (26%), Positives = 188/418 (44%), Gaps = 44/418 (10%)
Query: 107 PKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLD 166
PK++ +V +D +E ++ + G+ LFD+V + + L E +FGL Y+D + WL
Sbjct: 2 PKTISVRVTTMD-AELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLK 60
Query: 167 PAKEIKKQV--RSGAWHFSFNVKFYPPDPAQ-LSEDITRYYLCLQLRDDIVSGRLPCSFV 223
K++ Q + F F KFYP D ++ L +DIT+ LQ+++ I++ + C
Sbjct: 61 LNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPE 120
Query: 224 TLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKEL--------EDKVIELHKSHR 275
T LL SY VQS+ GD++ + S Y++ + P E E+++ H+ HR
Sbjct: 121 TAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHR 180
Query: 276 GMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRIN---RF 332
GM +A + +L+ A+ L MYGV+ K+ +G E+ LGV A GL IY R+ F
Sbjct: 181 GMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGF 240
Query: 333 AWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLP 392
W ++ IS+ F IK ++ F P R KR+ +C+ +H +
Sbjct: 241 PWSEIRNISFNDKKFVIK----PIDKKAPDFVFYAPRLRINKRILALCMGNHELY----- 291
Query: 393 EAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQ 452
+ R + Q +A A ++ ER+ + R + E +
Sbjct: 292 -----------MRRRKPDTIEVQQMKAQAREEKHQKQMERAMLENEKKKREM-AEKEKEK 339
Query: 453 YATTKGISQTNLITTVTPEKKAEEERDE--------EEDKRRKGEEVTPISAIRHEGK 502
K L KKA++E +E E++++R E ++ R E +
Sbjct: 340 IEREKEELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAE 397
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 137 bits (344), Expect = 7e-32
Identities = 110/408 (26%), Positives = 190/408 (46%), Gaps = 35/408 (8%)
Query: 107 PKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLD 166
PK + +V +D +E ++ + G+ LFD+V + + L E +FGL Y D++ WL
Sbjct: 2 PKPINVRVTTMD-AELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLK 60
Query: 167 PAKEIKKQ--VRSGAWHFSFNVKFYPPDPAQ-LSEDITRYYLCLQLRDDIVSGRLPCSFV 223
K++ +Q + F F KF+P D ++ L ++IT+ LQ+++ I++ + C
Sbjct: 61 LNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPE 120
Query: 224 TLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNH-------TKEL-EDKVIELHKSHR 275
T LL SY VQ++ GDY+ + Y++ R P TKE E+++ H+ HR
Sbjct: 121 TAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHR 180
Query: 276 GMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRIN---RF 332
GM ++ M +L+ A+ L MYGV+ K+ +G E+ LGV A GL IY ++ F
Sbjct: 181 GMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGF 240
Query: 333 AWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCV-EHHTFFRLLL 391
W ++ IS+ F IK ++ F P R KR+ +C+ H + R
Sbjct: 241 PWSEIRNISFNDKKFVIK----PIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRK 296
Query: 392 PEAPPKKFLTLGSKFRYSGRTQAQTRRAS--------ALIDRPAPYFERSSSKRYTMSRS 443
P+ + + ++ + Q Q RA + ++ ER + +
Sbjct: 297 PDTIEVQQMKAQAR---EEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQ 353
Query: 444 LDGEVGTGQYATTKGISQTNLITTVTPE-KKAEEERDEEEDKRRKGEE 490
++ + Q + QT + E K+A+EE + E +RR EE
Sbjct: 354 IEEQTIKAQKELEE---QTRKALELDQERKRAKEEAERLEKERRAAEE 398
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 134 bits (338), Expect = 4e-31
Identities = 95/310 (30%), Positives = 155/310 (50%), Gaps = 23/310 (7%)
Query: 93 SSKLSRSPLKIVKKPKSMQCKVILLDGS-EYTCDVEKRSRGQVLFDKVCEHLNLLEKDYF 151
+S++S S LK K+PK+ +++ +D E+ C E + +G+ LFD VC L L E +F
Sbjct: 6 ASRMSFSSLKR-KQPKTFTVRIVTMDAEMEFNC--EMKWKGKDLFDLVCRTLGLRETWFF 62
Query: 152 GLTYRDAENQKNWLDPAKEIKKQ--VRSGAWHFSFNVKFYPPDPAQ-LSEDITRYYLCLQ 208
GL Y ++ WL K++ + F F KFYP + + L ++IT++ LQ
Sbjct: 63 GLQYT-IKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQ 121
Query: 209 LRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKEL----- 263
++ I+ ++ C LL SY VQ++ GDYDP ++++ P L
Sbjct: 122 VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTP 181
Query: 264 ---EDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGL 320
E+++ + HRG EAEM +L+ A+ L MYGV+ ++ +G E++LGV A GL
Sbjct: 182 EMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGL 241
Query: 321 LIYRDRLRIN---RFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLW 377
IY R+ F W ++ ISY F IK + + F+ F R K +
Sbjct: 242 HIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLIL 297
Query: 378 KVCVEHHTFF 387
++C+ +H F
Sbjct: 298 QLCIGNHDLF 307
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 134 bits (338), Expect = 4e-31
Identities = 95/310 (30%), Positives = 155/310 (50%), Gaps = 23/310 (7%)
Query: 93 SSKLSRSPLKIVKKPKSMQCKVILLDGS-EYTCDVEKRSRGQVLFDKVCEHLNLLEKDYF 151
+S++S S LK K+PK+ +++ +D E+ C E + +G+ LFD VC L L E +F
Sbjct: 6 ASRMSFSSLKR-KQPKTFTVRIVTMDAEMEFNC--EMKWKGKDLFDLVCRTLGLRETWFF 62
Query: 152 GLTYRDAENQKNWLDPAKEIKKQ--VRSGAWHFSFNVKFYPPDPAQ-LSEDITRYYLCLQ 208
GL Y ++ WL K++ + F F KFYP + + L ++IT++ LQ
Sbjct: 63 GLQYT-IKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQ 121
Query: 209 LRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKEL----- 263
++ I+ ++ C LL SY VQ++ GDYDP ++++ P L
Sbjct: 122 VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTP 181
Query: 264 ---EDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGL 320
E+++ + HRG EAEM +L+ A+ L MYGV+ ++ +G E++LGV A GL
Sbjct: 182 EMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGL 241
Query: 321 LIYRDRLRIN---RFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLW 377
IY R+ F W ++ ISY F IK + + F+ F R K +
Sbjct: 242 HIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLIL 297
Query: 378 KVCVEHHTFF 387
++C+ +H F
Sbjct: 298 QLCIGNHDLF 307
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.361
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,477,416
Number of Sequences: 37866
Number of extensions: 2149517
Number of successful extensions: 15738
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 120
Number of HSP's successfully gapped in prelim test: 322
Number of HSP's that attempted gapping in prelim test: 12385
Number of HSP's gapped (non-prelim): 2832
length of query: 1087
length of database: 18,247,518
effective HSP length: 113
effective length of query: 974
effective length of database: 13,968,660
effective search space: 13605474840
effective search space used: 13605474840
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.