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Search of human proteins with 32483404
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32483404 GA binding protein transcription factor, beta
subunit 1 isoform gamma 2 [Homo sapiens]
(348 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32483404 GA binding protein transcription factor, beta subuni... 678 0.0
gi|8051599 GA binding protein transcription factor, beta subunit... 678 0.0
gi|8051597 GA binding protein transcription factor, beta subunit... 669 0.0
gi|8051595 GA binding protein transcription factor, beta subunit... 650 0.0
gi|8051593 GA binding protein transcription factor, beta subunit... 641 0.0
gi|21389427 GA repeat binding protein, beta 2 [Homo sapiens] 423 e-118
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 97 2e-20
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 96 5e-20
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 92 7e-19
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 92 7e-19
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 92 7e-19
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 92 7e-19
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 92 7e-19
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 92 7e-19
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 91 1e-18
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 91 1e-18
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 91 1e-18
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 86 4e-17
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 84 1e-16
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 84 1e-16
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 84 2e-16
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 84 2e-16
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 84 2e-16
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 84 2e-16
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 82 9e-16
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens] 82 9e-16
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens] 82 9e-16
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 81 2e-15
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 81 2e-15
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 80 2e-15
>gi|32483404 GA binding protein transcription factor, beta subunit 1
isoform gamma 2 [Homo sapiens]
Length = 348
Score = 678 bits (1750), Expect = 0.0
Identities = 348/348 (100%), Positives = 348/348 (100%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
Query: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
Query: 181 PQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVV 240
PQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVV
Sbjct: 181 PQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVV 240
Query: 241 TAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPA 300
TAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPA
Sbjct: 241 TAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPA 300
Query: 301 TDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK 348
TDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK
Sbjct: 301 TDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK 348
>gi|8051599 GA binding protein transcription factor, beta subunit 1
isoform gamma 2 [Homo sapiens]
Length = 348
Score = 678 bits (1750), Expect = 0.0
Identities = 348/348 (100%), Positives = 348/348 (100%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
Query: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
Query: 181 PQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVV 240
PQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVV
Sbjct: 181 PQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVV 240
Query: 241 TAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPA 300
TAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPA
Sbjct: 241 TAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPA 300
Query: 301 TDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK 348
TDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK
Sbjct: 301 TDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK 348
>gi|8051597 GA binding protein transcription factor, beta subunit 1
isoform gamma 1 [Homo sapiens]
Length = 360
Score = 669 bits (1727), Expect = 0.0
Identities = 348/360 (96%), Positives = 348/360 (96%), Gaps = 12/360 (3%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
Query: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
Query: 181 PQFIIGPGGVVNL------------TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 228
PQFIIGPGGVVNL TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS
Sbjct: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240
Query: 229 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 288
SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT
Sbjct: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300
Query: 289 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK 348
MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK
Sbjct: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLLPGVLCRSHPK 360
>gi|8051595 GA binding protein transcription factor, beta subunit 1
isoform beta 2 [Homo sapiens]
Length = 383
Score = 650 bits (1676), Expect = 0.0
Identities = 335/338 (99%), Positives = 335/338 (99%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
Query: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
Query: 181 PQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVV 240
PQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVV
Sbjct: 181 PQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVV 240
Query: 241 TAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPA 300
TAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPA
Sbjct: 241 TAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPA 300
Query: 301 TDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLL 338
TDIAEETVISEEPPAKRQCIEIIENRVESAEIE R L
Sbjct: 301 TDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREAL 338
>gi|8051593 GA binding protein transcription factor, beta subunit 1
isoform beta 1 [Homo sapiens]
Length = 395
Score = 641 bits (1653), Expect = 0.0
Identities = 335/350 (95%), Positives = 335/350 (95%), Gaps = 12/350 (3%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA
Sbjct: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
Query: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
Sbjct: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
Sbjct: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
Query: 181 PQFIIGPGGVVNL------------TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 228
PQFIIGPGGVVNL TDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS
Sbjct: 181 PQFIIGPGGVVNLTGLVSSENSSKATDETGVSAVQFGNSSTSVLATLAALAEASAPLSNS 240
Query: 229 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 288
SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT
Sbjct: 241 SETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGIGQPIIVT 300
Query: 289 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEVRSLL 338
MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIE R L
Sbjct: 301 MPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREAL 350
>gi|21389427 GA repeat binding protein, beta 2 [Homo sapiens]
Length = 448
Score = 423 bits (1088), Expect = e-118
Identities = 239/359 (66%), Positives = 271/359 (75%), Gaps = 23/359 (6%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
MSLVDLGK+LLEAAR GQDDEVR LMANGAPFTTDWLGTSPLHLAAQYGHYST EVLLRA
Sbjct: 1 MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRA 60
Query: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
GVSRDARTKVDRTPLHMAA++GHA IVE+L+++GADVNAKDMLKMTALHWATE +H++VV
Sbjct: 61 GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVV 120
Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT--IHA 178
ELLIKYGADVH SKF K+AFDI+++ N ++ ILQ AMQNQ+N NPE + VT +
Sbjct: 121 ELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSM 180
Query: 179 ATPQFIIGPGGVVNL------------TDETGVSAVQFGNSSTSVLATLAALAEASAPLS 226
A P FI G VVNL + + S VQF NS+TSVLATLAALAEAS PLS
Sbjct: 181 AAP-FIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLS 239
Query: 227 NSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNLH-SIPTSGIGQPI 285
NS TEE++ SVD +IQQV+ SGGQ+VITIVTDG+ LGN+ SIPT GIGQP
Sbjct: 240 NSHRA-TANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPF 298
Query: 286 IVTMPDGQQVLTVPATDIAEETVISEE-----PPAKRQCIEIIENRV-ESAEIEVRSLL 338
IVT+ DGQQVLTVPA +AEETVI EE P K+ I N V ES E R LL
Sbjct: 299 IVTVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELL 357
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 97.4 bits (241), Expect = 2e-20
Identities = 55/138 (39%), Positives = 80/138 (57%), Gaps = 2/138 (1%)
Query: 9 KLLEAARAGQDDEVRILMA--NGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDA 66
+LLE+AR+G ++++ L+ N +D ++PLHLAA Y ++LL+ G A
Sbjct: 180 ELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHA 239
Query: 67 RTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKY 126
+ K D PLH A S GH + E+L+KHGA VNA D+ + T LH A N EV LL+ Y
Sbjct: 240 KDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSY 299
Query: 127 GADVHTQSKFCKTAFDIS 144
GAD + K+A D++
Sbjct: 300 GADPTLLNCHNKSAIDLA 317
Score = 94.4 bits (233), Expect = 1e-19
Identities = 56/152 (36%), Positives = 86/152 (56%), Gaps = 3/152 (1%)
Query: 8 KKLLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRD 65
++LLEAA+AG + V+ L + D G ++PLH AA Y S E LL+ G
Sbjct: 494 RQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVH 553
Query: 66 ARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
A+ K PLH A S GH + E+L+KHGA VN D+ K T LH A E+ +LL++
Sbjct: 554 AKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQ 613
Query: 126 YGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
+GAD +++ T D+ + +G+ D+ ++L+
Sbjct: 614 HGADPTKKNRDGNTPLDL-VKDGDTDIQDLLR 644
Score = 82.8 bits (203), Expect = 4e-16
Identities = 50/139 (35%), Positives = 76/139 (54%), Gaps = 2/139 (1%)
Query: 8 KKLLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRD 65
++L EA R G + V+ L+ + D G ++PLH AA +G E LL+ G +
Sbjct: 26 RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ 85
Query: 66 ARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
AR PLH A S GHA +V +LL+HGAD NA+D T LH A +V +L++
Sbjct: 86 ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145
Query: 126 YGADVHTQSKFCKTAFDIS 144
+GA+ ++ +TA D++
Sbjct: 146 HGAEPTIRNTDGRTALDLA 164
Score = 82.8 bits (203), Expect = 4e-16
Identities = 77/259 (29%), Positives = 117/259 (45%), Gaps = 32/259 (12%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRDAR 67
LL+AA+ G V+ L + D G ++PLHLAA Y + E LL+ G +A+
Sbjct: 649 LLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQ 708
Query: 68 TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
K PLH AAS GH + +L+K+ A VNA D T LH A + ++ LL+ +G
Sbjct: 709 DKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 768
Query: 128 ADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIG- 186
AD +++ +T D+ +D++ +L AM P + PQ + G
Sbjct: 769 ADPTLKNQEGQTPLDLV---SADDVSALLTAAM----------PPSALPSCYKPQVLNGV 815
Query: 187 --PGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLS------NSSETPVVATEE 238
PG + A+ G SS S L+ ++L S S +SS T ++ E
Sbjct: 816 RSPGATAD--------ALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLE 867
Query: 239 VVTAESVDGAIQQVVSSGG 257
VD +I Q V + G
Sbjct: 868 KKEVPGVDFSITQFVRNLG 886
Score = 75.1 bits (183), Expect = 9e-14
Identities = 57/157 (36%), Positives = 80/157 (50%), Gaps = 12/157 (7%)
Query: 7 GKKLLEAARAGQDDEVRI---LMANGAPFTTDWLGTSPLHLAAQYGH---YSTTEVLLRA 60
G LL+AAR + D RI L F + LH AA + E+LLR
Sbjct: 332 GHSLLQAAR--EADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRK 389
Query: 61 GVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV 120
G + + +TK TPLH+A+ + H +VEV++KH A VNA D L T+LH A H +
Sbjct: 390 GANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTC 449
Query: 121 ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
LL+ YG D + S TA + GNE++ ++LQ
Sbjct: 450 RLLLSYGCDPNIISLQGFTALQM----GNENVQQLLQ 482
Score = 70.1 bits (170), Expect = 3e-12
Identities = 58/199 (29%), Positives = 82/199 (41%), Gaps = 55/199 (27%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G+ D V L+ NGA D G PLH A +GH +LLR G +AR +
Sbjct: 65 AAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWN 124
Query: 72 RTPLHMAASEGHASIVEVLLKHG----------------ADVNAKDML------------ 103
TPLH AA +G + VLL+HG AD +AK +L
Sbjct: 125 YTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLES 184
Query: 104 --------------------------KMTALHWATEHNHQEVVELLIKYGADVHTQSKFC 137
K T LH A +N ++V+LL+++GADVH + K
Sbjct: 185 ARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGD 244
Query: 138 KTAFDISIDNGNEDLAEIL 156
+ G+ ++ E+L
Sbjct: 245 LVPLHNACSYGHYEVTELL 263
Score = 58.5 bits (140), Expect = 8e-09
Identities = 32/84 (38%), Positives = 47/84 (55%)
Query: 73 TPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
TPLH AA G +VE LL++GA+V A+D + LH A H EVV LL+++GAD +
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
Query: 133 QSKFCKTAFDISIDNGNEDLAEIL 156
+ + T + G D+ +L
Sbjct: 120 RDNWNYTPLHEAAIKGKIDVCIVL 143
Score = 49.3 bits (116), Expect = 5e-06
Identities = 47/173 (27%), Positives = 73/173 (42%), Gaps = 30/173 (17%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A+ +D V +++ + A D LG + LH AA GH T +LL G + +
Sbjct: 407 ASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQG 466
Query: 72 RTPLHM--------------------------AASEGHASIVEVLLKHGADVNAKDM--L 103
T L M AA G V+ L + VN +D+
Sbjct: 467 FTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGR 525
Query: 104 KMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+ T LH+A +N VVE L+++GADVH + K + G+ ++AE+L
Sbjct: 526 QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELL 578
Score = 48.1 bits (113), Expect = 1e-05
Identities = 33/112 (29%), Positives = 50/112 (44%), Gaps = 15/112 (13%)
Query: 40 SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNA 99
+PLH+A++ H EV+++ +A + +T LH AA GH +LL +G D N
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 100 KDMLKMTALHWATEHNHQEVVELLIKYG--------------ADVHTQSKFC 137
+ TAL E N Q++++ I G DV T K C
Sbjct: 462 ISLQGFTALQMGNE-NVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC 512
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 95.9 bits (237), Expect = 5e-20
Identities = 56/155 (36%), Positives = 86/155 (55%), Gaps = 3/155 (1%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGV 62
D+ +LLEA++AG + V+ L ++ D G ++PLH AA Y S E LL G
Sbjct: 649 DVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGA 708
Query: 63 SRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVEL 122
A+ K PLH A S GH + E+L++HGA VN D+ K T LH A E+ +L
Sbjct: 709 DVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKL 768
Query: 123 LIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
L+K+GAD +++ T D+ + G+ D+ ++L+
Sbjct: 769 LLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLLR 802
Score = 94.0 bits (232), Expect = 2e-19
Identities = 55/138 (39%), Positives = 79/138 (57%), Gaps = 2/138 (1%)
Query: 9 KLLEAARAGQDDEVRILMA--NGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDA 66
+LLEAAR+G ++++ L+ N +D ++PLHLAA Y ++LL+ G A
Sbjct: 338 ELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA 397
Query: 67 RTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKY 126
+ K PLH A S GH + E+LLKHGA VNA D+ + T LH A N EV LL+ +
Sbjct: 398 KDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 457
Query: 127 GADVHTQSKFCKTAFDIS 144
GAD + K+A D++
Sbjct: 458 GADPTLVNCHGKSAVDMA 475
Score = 80.9 bits (198), Expect = 2e-15
Identities = 52/139 (37%), Positives = 74/139 (53%), Gaps = 2/139 (1%)
Query: 8 KKLLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRD 65
++LLEA R G V+ L+ D G +SPLH AA +G E LL+ G +
Sbjct: 184 RELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVH 243
Query: 66 ARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
AR PLH A S GHA +V +LL GAD NA+D T LH A +V +L++
Sbjct: 244 ARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 303
Query: 126 YGADVHTQSKFCKTAFDIS 144
+GAD + ++ K+A D++
Sbjct: 304 HGADPNIRNTDGKSALDLA 322
Score = 76.6 bits (187), Expect = 3e-14
Identities = 61/201 (30%), Positives = 91/201 (45%), Gaps = 11/201 (5%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLG--TSPLHLAAQYGHYSTTEVLLRAGVSRDAR 67
LL+AA+ G V+ L D G ++PLHLAA Y + E LL G +A+
Sbjct: 807 LLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ 866
Query: 68 TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
K PLH AAS GH I +L+K+ VNA D T LH A + ++ LL+ +G
Sbjct: 867 DKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 926
Query: 128 ADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIH------AATP 181
AD +++ +T D++ +D+ +L AM + P + A+TP
Sbjct: 927 ADPTMKNQEGQTPLDLAT---ADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTP 983
Query: 182 QFIIGPGGVVNLTDETGVSAV 202
+ + NLT AV
Sbjct: 984 SCLSAASSIDNLTGPLAELAV 1004
Score = 75.1 bits (183), Expect = 9e-14
Identities = 57/154 (37%), Positives = 76/154 (49%), Gaps = 8/154 (5%)
Query: 7 GKKLLEAARAGQDDEVRILMA-NGAPFTTDWLGTSPLHLAAQYGH---YSTTEVLLRAGV 62
G LL+AAR +V+ +A F + LH A H TE+LLR G
Sbjct: 490 GHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGA 549
Query: 63 SRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVEL 122
+ + + K TPLH+AA H ++EVL KHGA +NA D L TALH A H + L
Sbjct: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609
Query: 123 LIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
L+ YG+D S TA + GNE + +IL
Sbjct: 610 LLSYGSDPSIISLQGFTAAQM----GNEAVQQIL 639
Score = 63.2 bits (152), Expect = 3e-10
Identities = 56/199 (28%), Positives = 79/199 (39%), Gaps = 55/199 (27%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G+ D V L+ GA D G PLH A +GH +LL G +AR +
Sbjct: 223 AAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWN 282
Query: 72 RTPLHMAASEGHASIVEVLLKHG----------------ADVNAKDML------------ 103
TPLH AA +G + VLL+HG AD +AK +L
Sbjct: 283 YTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEA 342
Query: 104 --------------------------KMTALHWATEHNHQEVVELLIKYGADVHTQSKFC 137
K T LH A +N +V+LL+++GADVH + K
Sbjct: 343 ARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGG 402
Query: 138 KTAFDISIDNGNEDLAEIL 156
+ G+ ++ E+L
Sbjct: 403 LVPLHNACSYGHYEVTELL 421
Score = 52.4 bits (124), Expect = 6e-07
Identities = 31/84 (36%), Positives = 45/84 (53%)
Query: 73 TPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
+PLH AA G +VE LL+ GA+V+A+D + LH A H EVV LL+ GAD +
Sbjct: 218 SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNA 277
Query: 133 QSKFCKTAFDISIDNGNEDLAEIL 156
+ + T + G D+ +L
Sbjct: 278 RDNWNYTPLHEAAIKGKIDVCIVL 301
Score = 47.8 bits (112), Expect = 1e-05
Identities = 27/82 (32%), Positives = 40/82 (48%)
Query: 40 SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNA 99
+PLH+AA+ H EVL + G +A + +T LH AA GH +LL +G+D +
Sbjct: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
Query: 100 KDMLKMTALHWATEHNHQEVVE 121
+ TA E Q + E
Sbjct: 620 ISLQGFTAAQMGNEAVQQILSE 641
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 92.0 bits (227), Expect = 7e-19
Identities = 57/184 (30%), Positives = 94/184 (51%), Gaps = 9/184 (4%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ Q + R L+ G + + G +PLHLAAQ GH +LL + + K
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 701
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+ A EGH + +VL+KHG V+A + T LH A+ + + ++V+ L+++ ADV+
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 761
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K + + G+ D+ +L N SP+ V+ TP I G +
Sbjct: 762 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 813
Query: 192 NLTD 195
++TD
Sbjct: 814 SVTD 817
Score = 92.0 bits (227), Expect = 7e-19
Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G + V +L++ A + G +PLHL AQ GH +VL++ GV DA T++
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 734
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ G+ +V+ LL+H ADVNAK L + LH A + H ++V LL+K GA +
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
S T I+ G + ++L++
Sbjct: 795 EVSSDGTTPLAIAKRLGYISVTDVLKV 821
Score = 89.0 bits (219), Expect = 6e-18
Identities = 63/205 (30%), Positives = 100/205 (48%), Gaps = 8/205 (3%)
Query: 20 DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
D V++L+ G +P + W G +PLH+AA+ LL+ G S +A + TPLH+A
Sbjct: 616 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 675
Query: 79 ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
A EGHA +V +LL A+ N + +T LH + H V ++LIK+G V ++
Sbjct: 676 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 735
Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPESP-DTVTIHAATPQFIIGPGGVVNLTDET 197
T ++ GN L + L +Q+Q + N ++ +H A Q G +V L +
Sbjct: 736 TPLHVASHYGNIKLVKFL---LQHQADVNAKTKLGYSPLHQAAQQ---GHTDIVTLLLKN 789
Query: 198 GVSAVQFGNSSTSVLATLAALAEAS 222
G S + + T+ LA L S
Sbjct: 790 GASPNEVSSDGTTPLAIAKRLGYIS 814
Score = 86.3 bits (212), Expect = 4e-17
Identities = 58/172 (33%), Positives = 87/172 (50%), Gaps = 5/172 (2%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G + V++L+ N A P G +PLH+AA+ GH T LL S+ TK
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA G + E+LL+ A NA +T LH A HN+ ++V+LL+ G H
Sbjct: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQ 182
+ + T I+ ++ E+ + +Q + N ES VT +H A +
Sbjct: 630 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 678
Score = 85.9 bits (211), Expect = 5e-17
Identities = 64/243 (26%), Positives = 108/243 (44%), Gaps = 35/243 (14%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AAR+G D+ + NG T + G + LHLA++ GH LL +
Sbjct: 44 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 103
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
+ TK T LH+AA G +V L+ +GA+VNA+ T L+ A + NH EVV+ L
Sbjct: 104 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
++ GA+ + ++ T +++ G+E++ L IA +N
Sbjct: 164 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 223
Query: 164 -INTNPESPDTVTIHAATP-------------QFIIGPGGVVNLTDETGVSAVQFGNSST 209
+ N +PD ++ TP Q ++ G VN T + G++ + +
Sbjct: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 283
Query: 210 SVL 212
+V+
Sbjct: 284 NVI 286
Score = 84.3 bits (207), Expect = 1e-16
Identities = 58/180 (32%), Positives = 90/180 (50%), Gaps = 9/180 (5%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ GA P + G +PLH+A + H E+LL+ G S DA T+
Sbjct: 378 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 437
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ GH IV+ LL+ GA N ++ T LH A H EV + L++ A V+
Sbjct: 438 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 497
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K +T + G+ ++ ++L ++N N P+ T TP I G V
Sbjct: 498 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 549
Score = 82.8 bits (203), Expect = 4e-16
Identities = 59/219 (26%), Positives = 108/219 (49%), Gaps = 8/219 (3%)
Query: 23 RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
++L+ GA T G +PLH+A++ G+ +LL G + +TK + TPLH AA
Sbjct: 256 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 315
Query: 82 GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
GH I E+LL HGA + AK ++ +H A + +H + V LL++Y A++ + T
Sbjct: 316 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 375
Query: 142 DISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTI---HAATPQFIIGPGGVVNLTDE 196
++ G+ +A++L + A N N +P + H + ++ G ++ E
Sbjct: 376 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 435
Query: 197 TGVSAVQFGNSSTSVLATLAALAEASAP-LSN-SSETPV 233
+G++ + + + L ++P +SN ETP+
Sbjct: 436 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 474
Score = 80.1 bits (196), Expect = 3e-15
Identities = 68/224 (30%), Positives = 110/224 (49%), Gaps = 21/224 (9%)
Query: 13 AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AA+ D VR+L+ A T D L +PLH+AA GH+ +VLL G ++R
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 402
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + H ++E+LLK GA ++A +T LH A+ H +V+ L++ GA
Sbjct: 403 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 462
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
+ + +T ++ G+ ++A+ L +QN+ N ++ D T +H A IG
Sbjct: 463 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 516
Query: 189 GVVNLTDETGVS---AVQFGNSSTSVLA------TLAALAEASA 223
+V L E + A G++ + A T+ AL E A
Sbjct: 517 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 560
Score = 72.4 bits (176), Expect = 6e-13
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)
Query: 24 ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
+L +P ++ +PLH+AA+ GH + LL+ +A+ K D+TPLH AA GH
Sbjct: 456 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 515
Query: 84 ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
++V++LL++ A+ N T LH A H E V L++ A +K T +
Sbjct: 516 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 575
Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
+ G +AE+L + A N N +P V +H
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 611
Score = 72.0 bits (175), Expect = 7e-13
Identities = 74/269 (27%), Positives = 112/269 (41%), Gaps = 23/269 (8%)
Query: 13 AARAGQDDEVRILM---ANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AAR G + V L+ A+ A T G +PLH+AA+YG E+LL +A K
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 600
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + IV++LL G ++ T LH A + N EV L++YG
Sbjct: 601 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 660
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTI--------HAATP 181
+ +S T ++ G+ AE++ + + Q N N + +T H
Sbjct: 661 ANAESVQGVTPLHLAAQEGH---AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 717
Query: 182 QFIIGPGGVVNLTDETGVS----AVQFGN-SSTSVLATLAALAEASAPLSNS--SETPVV 234
+I G +V+ T G + A +GN L A A L S +
Sbjct: 718 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 777
Query: 235 ATEEVVTAESVDGAIQQVVSSGGQQVITI 263
++VT +GA VSS G + I
Sbjct: 778 GHTDIVTLLLKNGASPNEVSSDGTTPLAI 806
Score = 71.6 bits (174), Expect = 1e-12
Identities = 59/211 (27%), Positives = 91/211 (43%), Gaps = 13/211 (6%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
+S V + L AARAG + + L+ N A +PLH AA+ GH + ++LL
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
Query: 60 AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
+ + T TPLH+AA EGH V LL+ A T LH A ++ V
Sbjct: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 584
Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
ELL++ A + K T +++ + N D+ ++L SP + +
Sbjct: 585 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 636
Query: 180 TPQFIIGPGGVVNLTDETGVSAVQFGNSSTS 210
TP I V E S +Q+G S+ +
Sbjct: 637 TPLHIAAKQNQV----EVARSLLQYGGSANA 663
Score = 64.3 bits (155), Expect = 2e-10
Identities = 39/115 (33%), Positives = 62/115 (53%)
Query: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
LH+AA+ T VLL+ + D +K TPLH+AA + ++ ++LL GA VN
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 269
Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+T LH A+ + +V LL+ GA + T++K T + NG+ ++EIL
Sbjct: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324
Score = 60.8 bits (146), Expect = 2e-09
Identities = 56/225 (24%), Positives = 91/225 (40%), Gaps = 35/225 (15%)
Query: 13 AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA AGQD+ VR L+ GA G +PL++AAQ H + LL G +++ T+
Sbjct: 118 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 177
Query: 72 RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
TPL +A +GH ++V L+ +G D N + K
Sbjct: 178 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237
Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL-----Q 157
T LH A + + V +LL+ GA V+ + T I+ GN + +L Q
Sbjct: 238 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 297
Query: 158 IAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAV 202
I + + P H + ++ G + + G+S +
Sbjct: 298 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 342
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 92.0 bits (227), Expect = 7e-19
Identities = 57/184 (30%), Positives = 94/184 (51%), Gaps = 9/184 (4%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ Q + R L+ G + + G +PLHLAAQ GH +LL + + K
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+ A EGH + +VL+KHG V+A + T LH A+ + + ++V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K + + G+ D+ +L N SP+ V+ TP I G +
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 780
Query: 192 NLTD 195
++TD
Sbjct: 781 SVTD 784
Score = 92.0 bits (227), Expect = 7e-19
Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G + V +L++ A + G +PLHL AQ GH +VL++ GV DA T++
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ G+ +V+ LL+H ADVNAK L + LH A + H ++V LL+K GA +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
S T I+ G + ++L++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKV 788
Score = 89.0 bits (219), Expect = 6e-18
Identities = 63/205 (30%), Positives = 100/205 (48%), Gaps = 8/205 (3%)
Query: 20 DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
D V++L+ G +P + W G +PLH+AA+ LL+ G S +A + TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642
Query: 79 ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
A EGHA +V +LL A+ N + +T LH + H V ++LIK+G V ++
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPESP-DTVTIHAATPQFIIGPGGVVNLTDET 197
T ++ GN L + L +Q+Q + N ++ +H A Q G +V L +
Sbjct: 703 TPLHVASHYGNIKLVKFL---LQHQADVNAKTKLGYSPLHQAAQQ---GHTDIVTLLLKN 756
Query: 198 GVSAVQFGNSSTSVLATLAALAEAS 222
G S + + T+ LA L S
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYIS 781
Score = 86.3 bits (212), Expect = 4e-17
Identities = 58/172 (33%), Positives = 87/172 (50%), Gaps = 5/172 (2%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G + V++L+ N A P G +PLH+AA+ GH T LL S+ TK
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA G + E+LL+ A NA +T LH A HN+ ++V+LL+ G H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQ 182
+ + T I+ ++ E+ + +Q + N ES VT +H A +
Sbjct: 597 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Score = 85.9 bits (211), Expect = 5e-17
Identities = 64/243 (26%), Positives = 108/243 (44%), Gaps = 35/243 (14%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AAR+G D+ + NG T + G + LHLA++ GH LL +
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
+ TK T LH+AA G +V L+ +GA+VNA+ T L+ A + NH EVV+ L
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
++ GA+ + ++ T +++ G+E++ L IA +N
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 164 -INTNPESPDTVTIHAATP-------------QFIIGPGGVVNLTDETGVSAVQFGNSST 209
+ N +PD ++ TP Q ++ G VN T + G++ + +
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 210 SVL 212
+V+
Sbjct: 251 NVI 253
Score = 84.3 bits (207), Expect = 1e-16
Identities = 58/180 (32%), Positives = 90/180 (50%), Gaps = 9/180 (5%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ GA P + G +PLH+A + H E+LL+ G S DA T+
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ GH IV+ LL+ GA N ++ T LH A H EV + L++ A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K +T + G+ ++ ++L ++N N P+ T TP I G V
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 516
Score = 82.8 bits (203), Expect = 4e-16
Identities = 59/219 (26%), Positives = 108/219 (49%), Gaps = 8/219 (3%)
Query: 23 RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
++L+ GA T G +PLH+A++ G+ +LL G + +TK + TPLH AA
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 82 GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
GH I E+LL HGA + AK ++ +H A + +H + V LL++Y A++ + T
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 142 DISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTI---HAATPQFIIGPGGVVNLTDE 196
++ G+ +A++L + A N N +P + H + ++ G ++ E
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
Query: 197 TGVSAVQFGNSSTSVLATLAALAEASAP-LSN-SSETPV 233
+G++ + + + L ++P +SN ETP+
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 80.1 bits (196), Expect = 3e-15
Identities = 68/224 (30%), Positives = 110/224 (49%), Gaps = 21/224 (9%)
Query: 13 AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AA+ D VR+L+ A T D L +PLH+AA GH+ +VLL G ++R
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + H ++E+LLK GA ++A +T LH A+ H +V+ L++ GA
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
+ + +T ++ G+ ++A+ L +QN+ N ++ D T +H A IG
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 483
Query: 189 GVVNLTDETGVS---AVQFGNSSTSVLA------TLAALAEASA 223
+V L E + A G++ + A T+ AL E A
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Score = 72.4 bits (176), Expect = 6e-13
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)
Query: 24 ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
+L +P ++ +PLH+AA+ GH + LL+ +A+ K D+TPLH AA GH
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 84 ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
++V++LL++ A+ N T LH A H E V L++ A +K T +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
+ G +AE+L + A N N +P V +H
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Score = 72.4 bits (176), Expect = 6e-13
Identities = 88/352 (25%), Positives = 145/352 (41%), Gaps = 49/352 (13%)
Query: 13 AARAGQDDEVRILM---ANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AAR G + V L+ A+ A T G +PLH+AA+YG E+LL +A K
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + IV++LL G ++ T LH A + N EV L++YG
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTI--------HAATP 181
+ +S T ++ G+ AE++ + + Q N N + +T H
Sbjct: 628 ANAESVQGVTPLHLAAQEGH---AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 182 QFIIGPGGVVNLTDETGVS----AVQFGN-SSTSVLATLAALAEASAPLSNS--SETPVV 234
+I G +V+ T G + A +GN L A A L S +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Query: 235 ATEEVVTAESVDGAIQQVVSSGGQ------------------QVITIVTDGIQLGNLH-- 274
++VT +GA VSS G +V+T T + + + H
Sbjct: 745 GHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRM 804
Query: 275 SIPTSGIGQPIIVTMPDGQQVLTVPA-----TDIAEETVISEEPPAKRQCIE 321
S P + + + + V+ +G+++++ A D+ EE + + P Q +E
Sbjct: 805 SFPET-VDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVE 855
Score = 71.6 bits (174), Expect = 1e-12
Identities = 59/211 (27%), Positives = 91/211 (43%), Gaps = 13/211 (6%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
+S V + L AARAG + + L+ N A +PLH AA+ GH + ++LL
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 60 AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
+ + T TPLH+AA EGH V LL+ A T LH A ++ V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
ELL++ A + K T +++ + N D+ ++L SP + +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 603
Query: 180 TPQFIIGPGGVVNLTDETGVSAVQFGNSSTS 210
TP I V E S +Q+G S+ +
Sbjct: 604 TPLHIAAKQNQV----EVARSLLQYGGSANA 630
Score = 64.3 bits (155), Expect = 2e-10
Identities = 39/115 (33%), Positives = 62/115 (53%)
Query: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
LH+AA+ T VLL+ + D +K TPLH+AA + ++ ++LL GA VN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+T LH A+ + +V LL+ GA + T++K T + NG+ ++EIL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Score = 60.8 bits (146), Expect = 2e-09
Identities = 56/225 (24%), Positives = 91/225 (40%), Gaps = 35/225 (15%)
Query: 13 AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA AGQD+ VR L+ GA G +PL++AAQ H + LL G +++ T+
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 72 RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
TPL +A +GH ++V L+ +G D N + K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL-----Q 157
T LH A + + V +LL+ GA V+ + T I+ GN + +L Q
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 158 IAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAV 202
I + + P H + ++ G + + G+S +
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 92.0 bits (227), Expect = 7e-19
Identities = 57/184 (30%), Positives = 94/184 (51%), Gaps = 9/184 (4%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ Q + R L+ G + + G +PLHLAAQ GH +LL + + K
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+ A EGH + +VL+KHG V+A + T LH A+ + + ++V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K + + G+ D+ +L N SP+ V+ TP I G +
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 780
Query: 192 NLTD 195
++TD
Sbjct: 781 SVTD 784
Score = 92.0 bits (227), Expect = 7e-19
Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G + V +L++ A + G +PLHL AQ GH +VL++ GV DA T++
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ G+ +V+ LL+H ADVNAK L + LH A + H ++V LL+K GA +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
S T I+ G + ++L++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKV 788
Score = 89.0 bits (219), Expect = 6e-18
Identities = 63/205 (30%), Positives = 100/205 (48%), Gaps = 8/205 (3%)
Query: 20 DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
D V++L+ G +P + W G +PLH+AA+ LL+ G S +A + TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642
Query: 79 ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
A EGHA +V +LL A+ N + +T LH + H V ++LIK+G V ++
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPESP-DTVTIHAATPQFIIGPGGVVNLTDET 197
T ++ GN L + L +Q+Q + N ++ +H A Q G +V L +
Sbjct: 703 TPLHVASHYGNIKLVKFL---LQHQADVNAKTKLGYSPLHQAAQQ---GHTDIVTLLLKN 756
Query: 198 GVSAVQFGNSSTSVLATLAALAEAS 222
G S + + T+ LA L S
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYIS 781
Score = 86.3 bits (212), Expect = 4e-17
Identities = 58/172 (33%), Positives = 87/172 (50%), Gaps = 5/172 (2%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G + V++L+ N A P G +PLH+AA+ GH T LL S+ TK
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA G + E+LL+ A NA +T LH A HN+ ++V+LL+ G H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQ 182
+ + T I+ ++ E+ + +Q + N ES VT +H A +
Sbjct: 597 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Score = 85.9 bits (211), Expect = 5e-17
Identities = 64/243 (26%), Positives = 108/243 (44%), Gaps = 35/243 (14%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AAR+G D+ + NG T + G + LHLA++ GH LL +
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
+ TK T LH+AA G +V L+ +GA+VNA+ T L+ A + NH EVV+ L
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
++ GA+ + ++ T +++ G+E++ L IA +N
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 164 -INTNPESPDTVTIHAATP-------------QFIIGPGGVVNLTDETGVSAVQFGNSST 209
+ N +PD ++ TP Q ++ G VN T + G++ + +
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 210 SVL 212
+V+
Sbjct: 251 NVI 253
Score = 84.3 bits (207), Expect = 1e-16
Identities = 58/180 (32%), Positives = 90/180 (50%), Gaps = 9/180 (5%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ GA P + G +PLH+A + H E+LL+ G S DA T+
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ GH IV+ LL+ GA N ++ T LH A H EV + L++ A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K +T + G+ ++ ++L ++N N P+ T TP I G V
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 516
Score = 82.8 bits (203), Expect = 4e-16
Identities = 59/219 (26%), Positives = 108/219 (49%), Gaps = 8/219 (3%)
Query: 23 RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
++L+ GA T G +PLH+A++ G+ +LL G + +TK + TPLH AA
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 82 GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
GH I E+LL HGA + AK ++ +H A + +H + V LL++Y A++ + T
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 142 DISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTI---HAATPQFIIGPGGVVNLTDE 196
++ G+ +A++L + A N N +P + H + ++ G ++ E
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
Query: 197 TGVSAVQFGNSSTSVLATLAALAEASAP-LSN-SSETPV 233
+G++ + + + L ++P +SN ETP+
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 80.1 bits (196), Expect = 3e-15
Identities = 68/224 (30%), Positives = 110/224 (49%), Gaps = 21/224 (9%)
Query: 13 AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AA+ D VR+L+ A T D L +PLH+AA GH+ +VLL G ++R
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + H ++E+LLK GA ++A +T LH A+ H +V+ L++ GA
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
+ + +T ++ G+ ++A+ L +QN+ N ++ D T +H A IG
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 483
Query: 189 GVVNLTDETGVS---AVQFGNSSTSVLA------TLAALAEASA 223
+V L E + A G++ + A T+ AL E A
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Score = 72.4 bits (176), Expect = 6e-13
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)
Query: 24 ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
+L +P ++ +PLH+AA+ GH + LL+ +A+ K D+TPLH AA GH
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 84 ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
++V++LL++ A+ N T LH A H E V L++ A +K T +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
+ G +AE+L + A N N +P V +H
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Score = 72.4 bits (176), Expect = 6e-13
Identities = 88/352 (25%), Positives = 145/352 (41%), Gaps = 49/352 (13%)
Query: 13 AARAGQDDEVRILM---ANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AAR G + V L+ A+ A T G +PLH+AA+YG E+LL +A K
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + IV++LL G ++ T LH A + N EV L++YG
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTI--------HAATP 181
+ +S T ++ G+ AE++ + + Q N N + +T H
Sbjct: 628 ANAESVQGVTPLHLAAQEGH---AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 182 QFIIGPGGVVNLTDETGVS----AVQFGN-SSTSVLATLAALAEASAPLSNS--SETPVV 234
+I G +V+ T G + A +GN L A A L S +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Query: 235 ATEEVVTAESVDGAIQQVVSSGGQ------------------QVITIVTDGIQLGNLH-- 274
++VT +GA VSS G +V+T T + + + H
Sbjct: 745 GHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRM 804
Query: 275 SIPTSGIGQPIIVTMPDGQQVLTVPA-----TDIAEETVISEEPPAKRQCIE 321
S P + + + + V+ +G+++++ A D+ EE + + P Q +E
Sbjct: 805 SFPET-VDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVE 855
Score = 71.6 bits (174), Expect = 1e-12
Identities = 59/211 (27%), Positives = 91/211 (43%), Gaps = 13/211 (6%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
+S V + L AARAG + + L+ N A +PLH AA+ GH + ++LL
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 60 AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
+ + T TPLH+AA EGH V LL+ A T LH A ++ V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
ELL++ A + K T +++ + N D+ ++L SP + +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 603
Query: 180 TPQFIIGPGGVVNLTDETGVSAVQFGNSSTS 210
TP I V E S +Q+G S+ +
Sbjct: 604 TPLHIAAKQNQV----EVARSLLQYGGSANA 630
Score = 64.3 bits (155), Expect = 2e-10
Identities = 39/115 (33%), Positives = 62/115 (53%)
Query: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
LH+AA+ T VLL+ + D +K TPLH+AA + ++ ++LL GA VN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+T LH A+ + +V LL+ GA + T++K T + NG+ ++EIL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Score = 60.8 bits (146), Expect = 2e-09
Identities = 56/225 (24%), Positives = 91/225 (40%), Gaps = 35/225 (15%)
Query: 13 AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA AGQD+ VR L+ GA G +PL++AAQ H + LL G +++ T+
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 72 RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
TPL +A +GH ++V L+ +G D N + K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL-----Q 157
T LH A + + V +LL+ GA V+ + T I+ GN + +L Q
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 158 IAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAV 202
I + + P H + ++ G + + G+S +
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 92.0 bits (227), Expect = 7e-19
Identities = 57/184 (30%), Positives = 94/184 (51%), Gaps = 9/184 (4%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ Q + R L+ G + + G +PLHLAAQ GH +LL + + K
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+ A EGH + +VL+KHG V+A + T LH A+ + + ++V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K + + G+ D+ +L N SP+ V+ TP I G +
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 780
Query: 192 NLTD 195
++TD
Sbjct: 781 SVTD 784
Score = 92.0 bits (227), Expect = 7e-19
Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G + V +L++ A + G +PLHL AQ GH +VL++ GV DA T++
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ G+ +V+ LL+H ADVNAK L + LH A + H ++V LL+K GA +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
S T I+ G + ++L++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKV 788
Score = 89.0 bits (219), Expect = 6e-18
Identities = 63/205 (30%), Positives = 100/205 (48%), Gaps = 8/205 (3%)
Query: 20 DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
D V++L+ G +P + W G +PLH+AA+ LL+ G S +A + TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642
Query: 79 ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
A EGHA +V +LL A+ N + +T LH + H V ++LIK+G V ++
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPESP-DTVTIHAATPQFIIGPGGVVNLTDET 197
T ++ GN L + L +Q+Q + N ++ +H A Q G +V L +
Sbjct: 703 TPLHVASHYGNIKLVKFL---LQHQADVNAKTKLGYSPLHQAAQQ---GHTDIVTLLLKN 756
Query: 198 GVSAVQFGNSSTSVLATLAALAEAS 222
G S + + T+ LA L S
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYIS 781
Score = 86.3 bits (212), Expect = 4e-17
Identities = 58/172 (33%), Positives = 87/172 (50%), Gaps = 5/172 (2%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G + V++L+ N A P G +PLH+AA+ GH T LL S+ TK
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA G + E+LL+ A NA +T LH A HN+ ++V+LL+ G H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQ 182
+ + T I+ ++ E+ + +Q + N ES VT +H A +
Sbjct: 597 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Score = 85.9 bits (211), Expect = 5e-17
Identities = 64/243 (26%), Positives = 108/243 (44%), Gaps = 35/243 (14%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AAR+G D+ + NG T + G + LHLA++ GH LL +
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
+ TK T LH+AA G +V L+ +GA+VNA+ T L+ A + NH EVV+ L
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
++ GA+ + ++ T +++ G+E++ L IA +N
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 164 -INTNPESPDTVTIHAATP-------------QFIIGPGGVVNLTDETGVSAVQFGNSST 209
+ N +PD ++ TP Q ++ G VN T + G++ + +
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 210 SVL 212
+V+
Sbjct: 251 NVI 253
Score = 84.3 bits (207), Expect = 1e-16
Identities = 58/180 (32%), Positives = 90/180 (50%), Gaps = 9/180 (5%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ GA P + G +PLH+A + H E+LL+ G S DA T+
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ GH IV+ LL+ GA N ++ T LH A H EV + L++ A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K +T + G+ ++ ++L ++N N P+ T TP I G V
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 516
Score = 82.8 bits (203), Expect = 4e-16
Identities = 59/219 (26%), Positives = 108/219 (49%), Gaps = 8/219 (3%)
Query: 23 RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
++L+ GA T G +PLH+A++ G+ +LL G + +TK + TPLH AA
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 82 GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
GH I E+LL HGA + AK ++ +H A + +H + V LL++Y A++ + T
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 142 DISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTI---HAATPQFIIGPGGVVNLTDE 196
++ G+ +A++L + A N N +P + H + ++ G ++ E
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
Query: 197 TGVSAVQFGNSSTSVLATLAALAEASAP-LSN-SSETPV 233
+G++ + + + L ++P +SN ETP+
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 80.1 bits (196), Expect = 3e-15
Identities = 68/224 (30%), Positives = 110/224 (49%), Gaps = 21/224 (9%)
Query: 13 AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AA+ D VR+L+ A T D L +PLH+AA GH+ +VLL G ++R
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + H ++E+LLK GA ++A +T LH A+ H +V+ L++ GA
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
+ + +T ++ G+ ++A+ L +QN+ N ++ D T +H A IG
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 483
Query: 189 GVVNLTDETGVS---AVQFGNSSTSVLA------TLAALAEASA 223
+V L E + A G++ + A T+ AL E A
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Score = 72.4 bits (176), Expect = 6e-13
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)
Query: 24 ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
+L +P ++ +PLH+AA+ GH + LL+ +A+ K D+TPLH AA GH
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 84 ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
++V++LL++ A+ N T LH A H E V L++ A +K T +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
+ G +AE+L + A N N +P V +H
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Score = 72.4 bits (176), Expect = 6e-13
Identities = 88/352 (25%), Positives = 145/352 (41%), Gaps = 49/352 (13%)
Query: 13 AARAGQDDEVRILM---ANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AAR G + V L+ A+ A T G +PLH+AA+YG E+LL +A K
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + IV++LL G ++ T LH A + N EV L++YG
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTI--------HAATP 181
+ +S T ++ G+ AE++ + + Q N N + +T H
Sbjct: 628 ANAESVQGVTPLHLAAQEGH---AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 182 QFIIGPGGVVNLTDETGVS----AVQFGN-SSTSVLATLAALAEASAPLSNS--SETPVV 234
+I G +V+ T G + A +GN L A A L S +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Query: 235 ATEEVVTAESVDGAIQQVVSSGGQ------------------QVITIVTDGIQLGNLH-- 274
++VT +GA VSS G +V+T T + + + H
Sbjct: 745 GHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRM 804
Query: 275 SIPTSGIGQPIIVTMPDGQQVLTVPA-----TDIAEETVISEEPPAKRQCIE 321
S P + + + + V+ +G+++++ A D+ EE + + P Q +E
Sbjct: 805 SFPET-VDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVE 855
Score = 71.6 bits (174), Expect = 1e-12
Identities = 59/211 (27%), Positives = 91/211 (43%), Gaps = 13/211 (6%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
+S V + L AARAG + + L+ N A +PLH AA+ GH + ++LL
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 60 AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
+ + T TPLH+AA EGH V LL+ A T LH A ++ V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
ELL++ A + K T +++ + N D+ ++L SP + +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 603
Query: 180 TPQFIIGPGGVVNLTDETGVSAVQFGNSSTS 210
TP I V E S +Q+G S+ +
Sbjct: 604 TPLHIAAKQNQV----EVARSLLQYGGSANA 630
Score = 64.3 bits (155), Expect = 2e-10
Identities = 39/115 (33%), Positives = 62/115 (53%)
Query: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
LH+AA+ T VLL+ + D +K TPLH+AA + ++ ++LL GA VN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+T LH A+ + +V LL+ GA + T++K T + NG+ ++EIL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Score = 60.8 bits (146), Expect = 2e-09
Identities = 56/225 (24%), Positives = 91/225 (40%), Gaps = 35/225 (15%)
Query: 13 AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA AGQD+ VR L+ GA G +PL++AAQ H + LL G +++ T+
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 72 RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
TPL +A +GH ++V L+ +G D N + K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL-----Q 157
T LH A + + V +LL+ GA V+ + T I+ GN + +L Q
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 158 IAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAV 202
I + + P H + ++ G + + G+S +
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 92.0 bits (227), Expect = 7e-19
Identities = 57/184 (30%), Positives = 94/184 (51%), Gaps = 9/184 (4%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ Q + R L+ G + + G +PLHLAAQ GH +LL + + K
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+ A EGH + +VL+KHG V+A + T LH A+ + + ++V+ L+++ ADV+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K + + G+ D+ +L N SP+ V+ TP I G +
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLL--------KNGASPNEVSSDGTTPLAIAKRLGYI 780
Query: 192 NLTD 195
++TD
Sbjct: 781 SVTD 784
Score = 92.0 bits (227), Expect = 7e-19
Identities = 54/147 (36%), Positives = 84/147 (57%), Gaps = 1/147 (0%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G + V +L++ A + G +PLHL AQ GH +VL++ GV DA T++
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ G+ +V+ LL+H ADVNAK L + LH A + H ++V LL+K GA +
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
S T I+ G + ++L++
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVLKV 788
Score = 89.0 bits (219), Expect = 6e-18
Identities = 63/205 (30%), Positives = 100/205 (48%), Gaps = 8/205 (3%)
Query: 20 DEVRILMANG-APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
D V++L+ G +P + W G +PLH+AA+ LL+ G S +A + TPLH+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642
Query: 79 ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
A EGHA +V +LL A+ N + +T LH + H V ++LIK+G V ++
Sbjct: 643 AQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY 702
Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPESP-DTVTIHAATPQFIIGPGGVVNLTDET 197
T ++ GN L + L +Q+Q + N ++ +H A Q G +V L +
Sbjct: 703 TPLHVASHYGNIKLVKFL---LQHQADVNAKTKLGYSPLHQAAQQ---GHTDIVTLLLKN 756
Query: 198 GVSAVQFGNSSTSVLATLAALAEAS 222
G S + + T+ LA L S
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYIS 781
Score = 86.3 bits (212), Expect = 4e-17
Identities = 58/172 (33%), Positives = 87/172 (50%), Gaps = 5/172 (2%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G + V++L+ N A P G +PLH+AA+ GH T LL S+ TK
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA G + E+LL+ A NA +T LH A HN+ ++V+LL+ G H
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQ 182
+ + T I+ ++ E+ + +Q + N ES VT +H A +
Sbjct: 597 SPAWNGYTPLHIA---AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Score = 85.9 bits (211), Expect = 5e-17
Identities = 64/243 (26%), Positives = 108/243 (44%), Gaps = 35/243 (14%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AAR+G D+ + NG T + G + LHLA++ GH LL +
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
+ TK T LH+AA G +V L+ +GA+VNA+ T L+ A + NH EVV+ L
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLA--------------EILQIAMQNQ------ 163
++ GA+ + ++ T +++ G+E++ L IA +N
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 164 -INTNPESPDTVTIHAATP-------------QFIIGPGGVVNLTDETGVSAVQFGNSST 209
+ N +PD ++ TP Q ++ G VN T + G++ + +
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Query: 210 SVL 212
+V+
Sbjct: 251 NVI 253
Score = 84.3 bits (207), Expect = 1e-16
Identities = 58/180 (32%), Positives = 90/180 (50%), Gaps = 9/180 (5%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ GA P + G +PLH+A + H E+LL+ G S DA T+
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+A+ GH IV+ LL+ GA N ++ T LH A H EV + L++ A V+
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN 464
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
++K +T + G+ ++ ++L ++N N P+ T TP I G V
Sbjct: 465 AKAKDDQTPLHCAARIGHTNMVKLL---LENNAN-----PNLATTAGHTPLHIAAREGHV 516
Score = 82.8 bits (203), Expect = 4e-16
Identities = 59/219 (26%), Positives = 108/219 (49%), Gaps = 8/219 (3%)
Query: 23 RILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASE 81
++L+ GA T G +PLH+A++ G+ +LL G + +TK + TPLH AA
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 82 GHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAF 141
GH I E+LL HGA + AK ++ +H A + +H + V LL++Y A++ + T
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 142 DISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTI---HAATPQFIIGPGGVVNLTDE 196
++ G+ +A++L + A N N +P + H + ++ G ++ E
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402
Query: 197 TGVSAVQFGNSSTSVLATLAALAEASAP-LSN-SSETPV 233
+G++ + + + L ++P +SN ETP+
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 80.1 bits (196), Expect = 3e-15
Identities = 68/224 (30%), Positives = 110/224 (49%), Gaps = 21/224 (9%)
Query: 13 AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AA+ D VR+L+ A T D L +PLH+AA GH+ +VLL G ++R
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNSRAL 369
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + H ++E+LLK GA ++A +T LH A+ H +V+ L++ GA
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPG 188
+ + +T ++ G+ ++A+ L +QN+ N ++ D T +H A IG
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHCAAR---IGHT 483
Query: 189 GVVNLTDETGVS---AVQFGNSSTSVLA------TLAALAEASA 223
+V L E + A G++ + A T+ AL E A
Sbjct: 484 NMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Score = 72.4 bits (176), Expect = 6e-13
Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 2/156 (1%)
Query: 24 ILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGH 83
+L +P ++ +PLH+AA+ GH + LL+ +A+ K D+TPLH AA GH
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 84 ASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDI 143
++V++LL++ A+ N T LH A H E V L++ A +K T +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 144 SIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIH 177
+ G +AE+L + A N N +P V +H
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Score = 72.4 bits (176), Expect = 6e-13
Identities = 88/352 (25%), Positives = 145/352 (41%), Gaps = 49/352 (13%)
Query: 13 AARAGQDDEVRILM---ANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
AAR G + V L+ A+ A T G +PLH+AA+YG E+LL +A K
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+A + IV++LL G ++ T LH A + N EV L++YG
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTI--------HAATP 181
+ +S T ++ G+ AE++ + + Q N N + +T H
Sbjct: 628 ANAESVQGVTPLHLAAQEGH---AEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 182 QFIIGPGGVVNLTDETGVS----AVQFGN-SSTSVLATLAALAEASAPLSNS--SETPVV 234
+I G +V+ T G + A +GN L A A L S +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Query: 235 ATEEVVTAESVDGAIQQVVSSGGQ------------------QVITIVTDGIQLGNLH-- 274
++VT +GA VSS G +V+T T + + + H
Sbjct: 745 GHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRM 804
Query: 275 SIPTSGIGQPIIVTMPDGQQVLTVPA-----TDIAEETVISEEPPAKRQCIE 321
S P + + + + V+ +G+++++ A D+ EE + + P Q +E
Sbjct: 805 SFPET-VDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVE 855
Score = 71.6 bits (174), Expect = 1e-12
Identities = 59/211 (27%), Positives = 91/211 (43%), Gaps = 13/211 (6%)
Query: 1 MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLR 59
+S V + L AARAG + + L+ N A +PLH AA+ GH + ++LL
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 60 AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
+ + T TPLH+AA EGH V LL+ A T LH A ++ V
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAA 179
ELL++ A + K T +++ + N D+ ++L SP + +
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL--------PRGGSPHSPAWNGY 603
Query: 180 TPQFIIGPGGVVNLTDETGVSAVQFGNSSTS 210
TP I V E S +Q+G S+ +
Sbjct: 604 TPLHIAAKQNQV----EVARSLLQYGGSANA 630
Score = 64.3 bits (155), Expect = 2e-10
Identities = 39/115 (33%), Positives = 62/115 (53%)
Query: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
LH+AA+ T VLL+ + D +K TPLH+AA + ++ ++LL GA VN
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+T LH A+ + +V LL+ GA + T++K T + NG+ ++EIL
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Score = 60.8 bits (146), Expect = 2e-09
Identities = 56/225 (24%), Positives = 91/225 (40%), Gaps = 35/225 (15%)
Query: 13 AARAGQDDEVRILMANGAPFTTD-WLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA AGQD+ VR L+ GA G +PL++AAQ H + LL G +++ T+
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 72 RTPLHMAASEGHASIVEVLLKHGA---------------------------DVNAKDMLK 104
TPL +A +GH ++V L+ +G D N + K
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 105 --MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL-----Q 157
T LH A + + V +LL+ GA V+ + T I+ GN + +L Q
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 158 IAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAV 202
I + + P H + ++ G + + G+S +
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 92.0 bits (227), Expect = 7e-19
Identities = 53/154 (34%), Positives = 81/154 (52%)
Query: 6 LGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRD 65
L ++LL AA GQ + V L+ GA G +PLHLAA GH ++LL+AG D
Sbjct: 10 LSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLD 69
Query: 66 ARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
+ D+T LH A G+ I+ L+ G ++ +D TALH A+ H + +LL+K
Sbjct: 70 VQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVK 129
Query: 126 YGADVHTQSKFCKTAFDISIDNGNEDLAEILQIA 159
GA+V ++K TA ++ N + +L +A
Sbjct: 130 AGANVLAKNKAGNTALHLACQNSHSQSTRVLLLA 163
Score = 76.3 bits (186), Expect = 4e-14
Identities = 51/153 (33%), Positives = 78/153 (50%), Gaps = 1/153 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAP-FTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L EA+ G ++L+ GA + G + LHLA Q H +T VLL AG D +
Sbjct: 112 LHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKN 171
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
T LH+AA H SI+ +LL V+ K+ TALH A NH++V ++L++ GA
Sbjct: 172 NAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGA 231
Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQ 161
D + +T + + + N ++A +L A Q
Sbjct: 232 DTTIVNNAGQTPLETARYHNNPEVALLLTKAPQ 264
Score = 68.6 bits (166), Expect = 8e-12
Identities = 50/162 (30%), Positives = 80/162 (49%), Gaps = 6/162 (3%)
Query: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
L +AA G L+ G +R A TK RTPLH+AA++GH +V++LLK G D++ +D
Sbjct: 14 LLVAAYKGQTENVVQLINKG-ARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
Query: 102 MLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQ 161
TALH AT + E++ LI G + Q K TA + +G A++L A
Sbjct: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
Query: 162 NQINTNPESPDTVTI-----HAATPQFIIGPGGVVNLTDETG 198
N + N + + H+ + + ++ G +L + G
Sbjct: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAG 174
Score = 65.5 bits (158), Expect = 7e-11
Identities = 35/119 (29%), Positives = 63/119 (52%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G + LH A+ +G + ++L++AG + A+ K T LH+A H+ VLL G+
Sbjct: 108 GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRA 167
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+ K+ T LH A +NH ++ LL+ VH +++ TA ++ ++ +A+IL
Sbjct: 168 DLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKIL 226
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 91.3 bits (225), Expect = 1e-18
Identities = 55/153 (35%), Positives = 83/153 (54%), Gaps = 1/153 (0%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AARAG D+V + G T + G + LHLAA+ GH + LL G S
Sbjct: 9 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
D+ TK T LH+A+ G A +V+VL+K GA++NA+ T L+ A + NH +VV+ L
Sbjct: 69 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
++ GA+ T ++ T +++ G+ IL
Sbjct: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161
Score = 82.0 bits (201), Expect = 7e-16
Identities = 72/253 (28%), Positives = 114/253 (45%), Gaps = 24/253 (9%)
Query: 13 AARAGQDDEVRILMAN-GAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G D ++L+ A + G +PLH+AA Y + +LL G S A K
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA + I LL +GA+ N +T LH A++ H ++V LL+ GA++H
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 668
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIHAATPQ---FIIG 186
+K T+ ++ ++A+IL A Q+ +P V H + F++
Sbjct: 669 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 728
Query: 187 PGGVVNLTDETGVS----AVQFGNSS-TSVLATLAALAEASAPLSNSS------------ 229
G VN + G + A Q G++ +VL A A+ N++
Sbjct: 729 QGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISV 788
Query: 230 -ETPVVATEEVVT 241
+T V TEEV T
Sbjct: 789 VDTLKVVTEEVTT 801
Score = 81.3 bits (199), Expect = 1e-15
Identities = 49/155 (31%), Positives = 80/155 (51%), Gaps = 1/155 (0%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A++ G D V +L+ GA + G + LHLAAQ + ++L + G +DA TK+
Sbjct: 648 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 707
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL +A G+ +V LLK GA+VNAK T LH A + H ++ +L+++GA +
Sbjct: 708 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 767
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINT 166
+ TA I+ G + + L++ + T
Sbjct: 768 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 802
Score = 78.6 bits (192), Expect = 8e-15
Identities = 75/275 (27%), Positives = 123/275 (44%), Gaps = 22/275 (8%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G + V +L+ NGA P T+ G + LH+AA+ G LLR G DAR + +
Sbjct: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
+TPLH+A+ G IV++LL+H A +A T LH + +V +L++ GA
Sbjct: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIHAATPQFIIGPGG 189
+K T ++ G+ D+A++L + A + N +P V H +
Sbjct: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK------- 589
Query: 190 VVNLTDETGVS---AVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVD 246
V L E G S + G + + A + AS L+ +ET +V + V
Sbjct: 590 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT------ 643
Query: 247 GAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGI 281
+ G ++T++ D + N+H SG+
Sbjct: 644 -PLHLASQEGHTDMVTLLLD--KGANIHMSTKSGL 675
Score = 77.0 bits (188), Expect = 2e-14
Identities = 57/182 (31%), Positives = 91/182 (50%), Gaps = 9/182 (4%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ A P G +PLH+A + E+L++ G S A T+
Sbjct: 351 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TP+H+AA GH +IV +LL++GA + ++ TALH A EVV L++ GA V
Sbjct: 411 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 470
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+++ +T I+ G EI+Q+ +Q+ + PD T + TP I G V
Sbjct: 471 ARAREEQTPLHIASRLGK---TEIVQLLLQHMAH-----PDAATTNGYTPLHISAREGQV 522
Query: 192 NL 193
++
Sbjct: 523 DV 524
Score = 75.9 bits (185), Expect = 5e-14
Identities = 37/98 (37%), Positives = 60/98 (61%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G +PLH+AA YG+ + +LL G + D + TPLH+A+ G+ ++V++LL G +
Sbjct: 212 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 271
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSK 135
+AK +T LH A H +VVELL++ GA + ++K
Sbjct: 272 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309
Score = 75.5 bits (184), Expect = 7e-14
Identities = 58/221 (26%), Positives = 107/221 (48%), Gaps = 12/221 (5%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G + +L+ GA T G +PLH+A++ G+ + ++LL G DA+T+
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH AA GH +VE+LL+ GA + A+ ++ LH A + +H E V+ L+++ A V
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAA-------TPQF 183
+ TA ++ G+ + ++L + + N N + + T +H A +
Sbjct: 339 DVTLDYLTALHVAAHCGHYRVTKLL---LDKRANPNARALNGFTPLHIACKKNRIKVMEL 395
Query: 184 IIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAP 224
++ G + E+G++ + + L L ++P
Sbjct: 396 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436
Score = 70.9 bits (172), Expect = 2e-12
Identities = 42/119 (35%), Positives = 63/119 (52%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G +P+H+AA GH + +LL+ G S D T LHMAA G +V LL++GA V
Sbjct: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 469
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+A+ + T LH A+ E+V+LL+++ A + T IS G D+A +L
Sbjct: 470 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528
Score = 59.7 bits (143), Expect = 4e-09
Identities = 51/185 (27%), Positives = 88/185 (47%), Gaps = 11/185 (5%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G V+ L+ G+ + G + LH+A+ G +VL++ G + +A+++
Sbjct: 50 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 109
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL+MAA E H +V+ LL++GA+ + T L A + H + V +L+ +
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL----END 165
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESP---DTVTIHAATPQFIIGPG 188
T+ K A I+ + A +L +QN N + +S + T TP I
Sbjct: 166 TKGKVRLPALHIAARKDDTKSAALL---LQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 222
Query: 189 GVVNL 193
G VN+
Sbjct: 223 GNVNV 227
Score = 55.8 bits (133), Expect = 5e-08
Identities = 42/155 (27%), Positives = 78/155 (50%), Gaps = 11/155 (7%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
L A + G + V IL+ N T + LH+AA+ + +LL+ + D ++K
Sbjct: 146 LAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 202
Query: 70 --VDRT------PLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
V+RT PLH+AA G+ ++ +LL GA V+ +T LH A++ + +V+
Sbjct: 203 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 262
Query: 122 LLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
LL+ G + +++ T + +G++ + E+L
Sbjct: 263 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 297
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 91.3 bits (225), Expect = 1e-18
Identities = 55/153 (35%), Positives = 83/153 (54%), Gaps = 1/153 (0%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AARAG D+V + G T + G + LHLAA+ GH + LL G S
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
D+ TK T LH+A+ G A +V+VL+K GA++NA+ T L+ A + NH +VV+ L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
++ GA+ T ++ T +++ G+ IL
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Score = 82.0 bits (201), Expect = 7e-16
Identities = 72/253 (28%), Positives = 114/253 (45%), Gaps = 24/253 (9%)
Query: 13 AARAGQDDEVRILMAN-GAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G D ++L+ A + G +PLH+AA Y + +LL G S A K
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA + I LL +GA+ N +T LH A++ H ++V LL+ GA++H
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIHAATPQ---FIIG 186
+K T+ ++ ++A+IL A Q+ +P V H + F++
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 749
Query: 187 PGGVVNLTDETGVS----AVQFGNSS-TSVLATLAALAEASAPLSNSS------------ 229
G VN + G + A Q G++ +VL A A+ N++
Sbjct: 750 QGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISV 809
Query: 230 -ETPVVATEEVVT 241
+T V TEEV T
Sbjct: 810 VDTLKVVTEEVTT 822
Score = 81.3 bits (199), Expect = 1e-15
Identities = 49/155 (31%), Positives = 80/155 (51%), Gaps = 1/155 (0%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A++ G D V +L+ GA + G + LHLAAQ + ++L + G +DA TK+
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL +A G+ +V LLK GA+VNAK T LH A + H ++ +L+++GA +
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINT 166
+ TA I+ G + + L++ + T
Sbjct: 789 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 823
Score = 78.6 bits (192), Expect = 8e-15
Identities = 75/275 (27%), Positives = 123/275 (44%), Gaps = 22/275 (8%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G + V +L+ NGA P T+ G + LH+AA+ G LLR G DAR + +
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
+TPLH+A+ G IV++LL+H A +A T LH + +V +L++ GA
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIHAATPQFIIGPGG 189
+K T ++ G+ D+A++L + A + N +P V H +
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK------- 610
Query: 190 VVNLTDETGVS---AVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVD 246
V L E G S + G + + A + AS L+ +ET +V + V
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT------ 664
Query: 247 GAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGI 281
+ G ++T++ D + N+H SG+
Sbjct: 665 -PLHLASQEGHTDMVTLLLD--KGANIHMSTKSGL 696
Score = 77.0 bits (188), Expect = 2e-14
Identities = 57/182 (31%), Positives = 91/182 (50%), Gaps = 9/182 (4%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ A P G +PLH+A + E+L++ G S A T+
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TP+H+AA GH +IV +LL++GA + ++ TALH A EVV L++ GA V
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+++ +T I+ G EI+Q+ +Q+ + PD T + TP I G V
Sbjct: 492 ARAREEQTPLHIASRLGK---TEIVQLLLQHMAH-----PDAATTNGYTPLHISAREGQV 543
Query: 192 NL 193
++
Sbjct: 544 DV 545
Score = 75.9 bits (185), Expect = 5e-14
Identities = 37/98 (37%), Positives = 60/98 (61%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G +PLH+AA YG+ + +LL G + D + TPLH+A+ G+ ++V++LL G +
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSK 135
+AK +T LH A H +VVELL++ GA + ++K
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
Score = 75.5 bits (184), Expect = 7e-14
Identities = 58/221 (26%), Positives = 107/221 (48%), Gaps = 12/221 (5%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G + +L+ GA T G +PLH+A++ G+ + ++LL G DA+T+
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH AA GH +VE+LL+ GA + A+ ++ LH A + +H E V+ L+++ A V
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAA-------TPQF 183
+ TA ++ G+ + ++L + + N N + + T +H A +
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLL---LDKRANPNARALNGFTPLHIACKKNRIKVMEL 416
Query: 184 IIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAP 224
++ G + E+G++ + + L L ++P
Sbjct: 417 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Score = 70.9 bits (172), Expect = 2e-12
Identities = 42/119 (35%), Positives = 63/119 (52%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G +P+H+AA GH + +LL+ G S D T LHMAA G +V LL++GA V
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+A+ + T LH A+ E+V+LL+++ A + T IS G D+A +L
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Score = 59.7 bits (143), Expect = 4e-09
Identities = 51/185 (27%), Positives = 88/185 (47%), Gaps = 11/185 (5%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G V+ L+ G+ + G + LH+A+ G +VL++ G + +A+++
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL+MAA E H +V+ LL++GA+ + T L A + H + V +L+ +
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL----END 186
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESP---DTVTIHAATPQFIIGPG 188
T+ K A I+ + A +L +QN N + +S + T TP I
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALL---LQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243
Query: 189 GVVNL 193
G VN+
Sbjct: 244 GNVNV 248
Score = 55.8 bits (133), Expect = 5e-08
Identities = 42/155 (27%), Positives = 78/155 (50%), Gaps = 11/155 (7%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
L A + G + V IL+ N T + LH+AA+ + +LL+ + D ++K
Sbjct: 167 LAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223
Query: 70 --VDRT------PLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
V+RT PLH+AA G+ ++ +LL GA V+ +T LH A++ + +V+
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Query: 122 LLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
LL+ G + +++ T + +G++ + E+L
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 91.3 bits (225), Expect = 1e-18
Identities = 55/153 (35%), Positives = 83/153 (54%), Gaps = 1/153 (0%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AARAG D+V + G T + G + LHLAA+ GH + LL G S
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
D+ TK T LH+A+ G A +V+VL+K GA++NA+ T L+ A + NH +VV+ L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
++ GA+ T ++ T +++ G+ IL
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Score = 82.0 bits (201), Expect = 7e-16
Identities = 72/253 (28%), Positives = 114/253 (45%), Gaps = 24/253 (9%)
Query: 13 AARAGQDDEVRILMAN-GAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G D ++L+ A + G +PLH+AA Y + +LL G S A K
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA + I LL +GA+ N +T LH A++ H ++V LL+ GA++H
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIHAATPQ---FIIG 186
+K T+ ++ ++A+IL A Q+ +P V H + F++
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 749
Query: 187 PGGVVNLTDETGVS----AVQFGNSS-TSVLATLAALAEASAPLSNSS------------ 229
G VN + G + A Q G++ +VL A A+ N++
Sbjct: 750 QGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISV 809
Query: 230 -ETPVVATEEVVT 241
+T V TEEV T
Sbjct: 810 VDTLKVVTEEVTT 822
Score = 81.3 bits (199), Expect = 1e-15
Identities = 49/155 (31%), Positives = 80/155 (51%), Gaps = 1/155 (0%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A++ G D V +L+ GA + G + LHLAAQ + ++L + G +DA TK+
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL +A G+ +V LLK GA+VNAK T LH A + H ++ +L+++GA +
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINT 166
+ TA I+ G + + L++ + T
Sbjct: 789 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTT 823
Score = 78.6 bits (192), Expect = 8e-15
Identities = 75/275 (27%), Positives = 123/275 (44%), Gaps = 22/275 (8%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G + V +L+ NGA P T+ G + LH+AA+ G LLR G DAR + +
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
+TPLH+A+ G IV++LL+H A +A T LH + +V +L++ GA
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIHAATPQFIIGPGG 189
+K T ++ G+ D+A++L + A + N +P V H +
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK------- 610
Query: 190 VVNLTDETGVS---AVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVD 246
V L E G S + G + + A + AS L+ +ET +V + V
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT------ 664
Query: 247 GAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGI 281
+ G ++T++ D + N+H SG+
Sbjct: 665 -PLHLASQEGHTDMVTLLLD--KGANIHMSTKSGL 696
Score = 77.0 bits (188), Expect = 2e-14
Identities = 57/182 (31%), Positives = 91/182 (50%), Gaps = 9/182 (4%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ A P G +PLH+A + E+L++ G S A T+
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TP+H+AA GH +IV +LL++GA + ++ TALH A EVV L++ GA V
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+++ +T I+ G EI+Q+ +Q+ + PD T + TP I G V
Sbjct: 492 ARAREEQTPLHIASRLGK---TEIVQLLLQHMAH-----PDAATTNGYTPLHISAREGQV 543
Query: 192 NL 193
++
Sbjct: 544 DV 545
Score = 75.9 bits (185), Expect = 5e-14
Identities = 37/98 (37%), Positives = 60/98 (61%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G +PLH+AA YG+ + +LL G + D + TPLH+A+ G+ ++V++LL G +
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSK 135
+AK +T LH A H +VVELL++ GA + ++K
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
Score = 75.5 bits (184), Expect = 7e-14
Identities = 58/221 (26%), Positives = 107/221 (48%), Gaps = 12/221 (5%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G + +L+ GA T G +PLH+A++ G+ + ++LL G DA+T+
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH AA GH +VE+LL+ GA + A+ ++ LH A + +H E V+ L+++ A V
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAA-------TPQF 183
+ TA ++ G+ + ++L + + N N + + T +H A +
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLL---LDKRANPNARALNGFTPLHIACKKNRIKVMEL 416
Query: 184 IIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAP 224
++ G + E+G++ + + L L ++P
Sbjct: 417 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Score = 70.9 bits (172), Expect = 2e-12
Identities = 42/119 (35%), Positives = 63/119 (52%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G +P+H+AA GH + +LL+ G S D T LHMAA G +V LL++GA V
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+A+ + T LH A+ E+V+LL+++ A + T IS G D+A +L
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Score = 59.7 bits (143), Expect = 4e-09
Identities = 51/185 (27%), Positives = 88/185 (47%), Gaps = 11/185 (5%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G V+ L+ G+ + G + LH+A+ G +VL++ G + +A+++
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL+MAA E H +V+ LL++GA+ + T L A + H + V +L+ +
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL----END 186
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESP---DTVTIHAATPQFIIGPG 188
T+ K A I+ + A +L +QN N + +S + T TP I
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALL---LQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243
Query: 189 GVVNL 193
G VN+
Sbjct: 244 GNVNV 248
Score = 55.8 bits (133), Expect = 5e-08
Identities = 42/155 (27%), Positives = 78/155 (50%), Gaps = 11/155 (7%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
L A + G + V IL+ N T + LH+AA+ + +LL+ + D ++K
Sbjct: 167 LAVALQQGHNQAVAILLEND---TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223
Query: 70 --VDRT------PLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
V+RT PLH+AA G+ ++ +LL GA V+ +T LH A++ + +V+
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Query: 122 LLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
LL+ G + +++ T + +G++ + E+L
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 86.3 bits (212), Expect = 4e-17
Identities = 61/192 (31%), Positives = 93/192 (48%), Gaps = 6/192 (3%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G ++L+ A P G +PLH+A + E+LL+ G S A T+
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TP+H+AA GH +IV L+ HGA N ++ TALH A EVV L++ GA V
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE 493
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTI---HAATPQFIIG 186
++K +T IS G D+ + L Q A N T+ +P ++ H F++
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLD 553
Query: 187 PGGVVNLTDETG 198
G +++T + G
Sbjct: 554 HGASLSITTKKG 565
Score = 84.3 bits (207), Expect = 1e-16
Identities = 69/276 (25%), Positives = 120/276 (43%), Gaps = 16/276 (5%)
Query: 24 ILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEG 82
+L+ GA P G +PLH+AA+ LL G +A T+ +H+AA EG
Sbjct: 616 LLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEG 675
Query: 83 HASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFD 142
H +V +LL A+VN + +T LH A + + V E+L+ GA V Q+K T
Sbjct: 676 HVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLH 735
Query: 143 ISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAATPQFIIGPGGVVNLTDETGVSA 201
+ GN +I+ +Q+ N ++ + T +H A Q G ++N+ + S
Sbjct: 736 VGCHYGN---IKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQ---GHTHIINVLLQNNASP 789
Query: 202 VQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVI 261
+ + + L L S +T + TEE +T +V + V +V+
Sbjct: 790 NELTVNGNTALGIARRLGYISV-----VDTLKIVTEETMTTTTVTEKHKMNVPETMNEVL 844
Query: 262 TIVTDGIQLGNLHSIPTSGIGQPIIVTMPDGQQVLT 297
+ D ++ N + + G I + +G+ +T
Sbjct: 845 DMSDDEVRKANAPEMLSDG---EYISDVEEGEDAMT 877
Score = 84.0 bits (206), Expect = 2e-16
Identities = 50/153 (32%), Positives = 80/153 (52%), Gaps = 1/153 (0%)
Query: 5 DLGKKLLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
D L AARAG ++ + NG + G + LHLA++ GH LL+ +
Sbjct: 40 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 99
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
DA TK T LH+A+ G A +V+VL+ +GA+VNA+ T L+ A + NH EVV+ L
Sbjct: 100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+ GA ++ T +++ G++ + +L
Sbjct: 160 LDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192
Score = 84.0 bits (206), Expect = 2e-16
Identities = 52/155 (33%), Positives = 79/155 (50%), Gaps = 1/155 (0%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA+ G D V +L+ A ++ G +PLHLAAQ + EVL+ G DA+TK+
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+ G+ IV LL+H A VNAK T LH A + H ++ +L++ A +
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINT 166
+ TA I+ G + + L+I + + T
Sbjct: 791 ELTVNGNTALGIARRLGYISVVDTLKIVTEETMTT 825
Score = 81.3 bits (199), Expect = 1e-15
Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 12/197 (6%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
+AR G+ D V+ L+ GA P G +PLHL+A+ GH LL G S TK
Sbjct: 506 SARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKG 565
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA G + +LL+ A +A +T LH A +++Q+V LL+ GA H
Sbjct: 566 FTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPH 625
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTV-TIHAATPQ-------F 183
+K T I+ D+A L ++ + N + + ++H A +
Sbjct: 626 AAAKNGYTPLHIAAKKNQMDIATTL---LEYGADANAVTRQGIASVHLAAQEGHVDMVSL 682
Query: 184 IIGPGGVVNLTDETGVS 200
++G VNL++++G++
Sbjct: 683 LLGRNANVNLSNKSGLT 699
Score = 80.5 bits (197), Expect = 2e-15
Identities = 50/145 (34%), Positives = 77/145 (53%), Gaps = 1/145 (0%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G + V LM +GA P TT+ G + LH+AA+ G L++ G +A+ K D
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
+TPLH++A G A IV+ LL+ GA NA T LH + H++V L+ +GA +
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL 156
+K T ++ G ++A +L
Sbjct: 560 ITTKKGFTPLHVAAKYGKLEVANLL 584
Score = 79.7 bits (195), Expect = 4e-15
Identities = 53/168 (31%), Positives = 86/168 (51%), Gaps = 9/168 (5%)
Query: 14 ARAGQDDEVRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDR 72
AR+G + V +L+ AP + G SPLH+A Q H + ++LL+ V D T
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL 368
Query: 73 TPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
T LH+AA GH + +VLL A+ NAK + T LH A + N +V+ELL+K+GA +
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 133 QSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT 180
++ T ++ G+ ++ +Q+ + SP+T + T
Sbjct: 429 VTESGLTPIHVAAFMGHVNIV--------SQLMHHGASPNTTNVRGET 468
Score = 79.7 bits (195), Expect = 4e-15
Identities = 52/199 (26%), Positives = 91/199 (45%), Gaps = 6/199 (3%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
+AR G +D L+ +GA + T G +PLH+AA+YG +LL+ S DA K
Sbjct: 539 SAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSG 598
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH+AA + + +LL GA +A T LH A + N ++ L++YGAD +
Sbjct: 599 LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN 658
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL-----QIAMQNQINTNPESPDTVTIHAATPQFIIG 186
++ + ++ G+ D+ +L + + N+ P + ++
Sbjct: 659 AVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVN 718
Query: 187 PGGVVNLTDETGVSAVQFG 205
G V+ + G + + G
Sbjct: 719 QGAHVDAQTKMGYTPLHVG 737
Score = 78.2 bits (191), Expect = 1e-14
Identities = 65/228 (28%), Positives = 102/228 (44%), Gaps = 15/228 (6%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR+GQ + VR L+ +GA +PLH++A+ G + LL+ G S +A T
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH++A EGH + LL HGA ++ T LH A ++ EV LL++ A
Sbjct: 533 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 592
Query: 132 TQSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIHAATPQ------- 182
K T ++ N+ +A +L Q A + N +P +H A +
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTP----LHIAAKKNQMDIAT 648
Query: 183 FIIGPGGVVNLTDETGVSAVQFGNSSTSV-LATLAALAEASAPLSNSS 229
++ G N G+++V V + +L A+ LSN S
Sbjct: 649 TLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS 696
Score = 77.0 bits (188), Expect = 2e-14
Identities = 43/143 (30%), Positives = 80/143 (55%), Gaps = 4/143 (2%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G +PLH+AA YG+ + +LL + D + D TPLH+A+ G+A++V++LL GA +
Sbjct: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
+AK +T LH H++VVE+L+ A + +++K + ++ D +Q
Sbjct: 295 DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQG---DHLNCVQ 351
Query: 158 IAMQNQINTNPESPDTVT-IHAA 179
+ +Q+ + + + D +T +H A
Sbjct: 352 LLLQHNVPVDDVTNDYLTALHVA 374
Score = 74.7 bits (182), Expect = 1e-13
Identities = 46/171 (26%), Positives = 89/171 (52%), Gaps = 11/171 (6%)
Query: 40 SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNA 99
+PLH+A++ G+ + ++LL G DA+T+ TPLH A GH +VE+LL A + +
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329
Query: 100 KDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIA 159
K ++ LH AT+ +H V+LL+++ V + TA ++ G+ +A++L
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL--- 386
Query: 160 MQNQINTNPESPDTVT-IHAA-------TPQFIIGPGGVVNLTDETGVSAV 202
+ + N N ++ + T +H A + ++ G + E+G++ +
Sbjct: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPI 437
Score = 74.7 bits (182), Expect = 1e-13
Identities = 47/157 (29%), Positives = 82/157 (52%), Gaps = 8/157 (5%)
Query: 22 VRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMA 78
V++L+ + P T D+L + LH+AA GHY +VLL + +A+ TPLH+A
Sbjct: 350 VQLLLQHNVPVDDVTNDYL--TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIA 407
Query: 79 ASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCK 138
+ ++E+LLKHGA + A +T +H A H +V L+ +GA +T + +
Sbjct: 408 CKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE 467
Query: 139 TAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT 175
TA ++ +G AE+++ +Q+ ++ D T
Sbjct: 468 TALHMAARSGQ---AEVVRYLVQDGAQVEAKAKDDQT 501
Score = 65.5 bits (158), Expect = 7e-11
Identities = 65/255 (25%), Positives = 106/255 (41%), Gaps = 18/255 (7%)
Query: 13 AARAGQDDEVRILMANGAPF---TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
A++ G + V++L+ GA T D G +PLH A+ GH E+LL ++TK
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRD--GLTPLHCGARSGHEQVVEMLLDRAAPILSKTK 332
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
+PLHMA H + V++LL+H V+ +TALH A H +V ++L+ A+
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEIL-----QIAMQNQINTNPESPDTVTIHAATPQFI 184
+ ++ T I+ + E+L I + P H +
Sbjct: 393 PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQL 452
Query: 185 IGPGGVVNLTDETGVSAVQFGNSS-----TSVLATLAALAEASAPLSNSSETPVVATEEV 239
+ G N T+ G +A+ S L A EA A +TP+ + +
Sbjct: 453 MHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA---KDDQTPLHISARL 509
Query: 240 VTAESVDGAIQQVVS 254
A+ V +QQ S
Sbjct: 510 GKADIVQQLLQQGAS 524
Score = 60.5 bits (145), Expect = 2e-09
Identities = 41/147 (27%), Positives = 72/147 (48%), Gaps = 3/147 (2%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
L A + G D V +L+ N T + LH+AA+ +LL+ + D +K
Sbjct: 177 LAVALQQGHDQVVSLLLEND---TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESK 233
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
TPLH+AA G+ ++ +LL A V+ +T LH A++ + +V+LL+ GA
Sbjct: 234 SGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAK 293
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEIL 156
+ +++ T +G+E + E+L
Sbjct: 294 IDAKTRDGLTPLHCGARSGHEQVVEML 320
Score = 58.2 bits (139), Expect = 1e-08
Identities = 44/143 (30%), Positives = 70/143 (48%), Gaps = 8/143 (5%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G + LH+A+ G +VL+ G + +A+++ TPL+MAA E H +V+ LL +GA
Sbjct: 107 GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
+ T L A + H +VV LL+ + T+ K A I+ + A +L
Sbjct: 167 SLATEDGFTPLAVALQQGHDQVVSLLL----ENDTKGKVRLPALHIAARKDDTKAAALL- 221
Query: 158 IAMQNQINTNPESPDTVT-IHAA 179
+QN N + ES T +H A
Sbjct: 222 --LQNDNNADVESKSGFTPLHIA 242
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 84.3 bits (207), Expect = 1e-16
Identities = 53/141 (37%), Positives = 73/141 (51%), Gaps = 1/141 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
LL AA AG+ +R L+A GA D G + L LAA G EVLL G R
Sbjct: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
+ R+ LH AA+ GH V++L+ GA+V+A+D L +T LH A+ H EV L+ GA
Sbjct: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGA 326
Query: 129 DVHTQSKFCKTAFDISIDNGN 149
V KT ++ + G+
Sbjct: 327 QVDATGWLRKTPLHLAAERGH 347
Score = 84.3 bits (207), Expect = 1e-16
Identities = 48/129 (37%), Positives = 68/129 (52%), Gaps = 1/129 (0%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G+ ++ +L+ +GA P D G S LH AA GH ++L+ G DAR +
Sbjct: 243 AAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLG 302
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH A+ EGH + LL GA V+A L+ T LH A E H V LL+ GA
Sbjct: 303 LTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPT 362
Query: 132 TQSKFCKTA 140
++++ + A
Sbjct: 363 LRTQWAEVA 371
Score = 70.1 bits (170), Expect = 3e-12
Identities = 37/78 (47%), Positives = 45/78 (57%)
Query: 57 LLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNH 116
LLR G S + R RTPLH+A GHA +V +LL+ GA V A D TALH A H H
Sbjct: 60 LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
Query: 117 QEVVELLIKYGADVHTQS 134
V ELL++ GA +S
Sbjct: 120 SRVAELLLQRGASAAARS 137
Score = 68.6 bits (166), Expect = 8e-12
Identities = 47/121 (38%), Positives = 59/121 (48%), Gaps = 5/121 (4%)
Query: 13 AARAGQDDEVRILMANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A G VR+L+ GAP D G + LH AA +GH E+LL+ G S AR+
Sbjct: 81 AVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTG 140
Query: 72 RTPLHMAASEGHASIVEVLLKHG----ADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
TPLH AA+ GH + LL+ A A+D TA HWA V+ELL G
Sbjct: 141 LTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGG 200
Query: 128 A 128
A
Sbjct: 201 A 201
Score = 67.4 bits (163), Expect = 2e-11
Identities = 42/117 (35%), Positives = 57/117 (48%), Gaps = 1/117 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
LL+A G V L+ GA D G +PLHLA GH +LL+ G A
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIK 125
+ RT LH AA GH+ + E+LL+ GA A+ +T LHWA H + L++
Sbjct: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLE 161
Score = 60.5 bits (145), Expect = 2e-09
Identities = 46/144 (31%), Positives = 65/144 (45%), Gaps = 6/144 (4%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDR 72
AA G+ + +L A GA L +AA G + LL G DAR
Sbjct: 184 AAAGGRLAVLELLAAGGAGLD------GALLVAAAAGRGAALRFLLARGARVDARDGAGA 237
Query: 73 TPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
T L +AA+ G + +EVLL HGAD +D +ALH A H V+LL+ GA+V
Sbjct: 238 TALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDA 297
Query: 133 QSKFCKTAFDISIDNGNEDLAEIL 156
+ T + G+ ++A L
Sbjct: 298 RDTLGLTPLHHASREGHVEVAGCL 321
Score = 44.7 bits (104), Expect = 1e-04
Identities = 28/82 (34%), Positives = 41/82 (50%)
Query: 75 LHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQS 134
L A G A +V LL+ GA V +D T LH A H +V LL++ GA V
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
Query: 135 KFCKTAFDISIDNGNEDLAEIL 156
+ +TA + +G+ +AE+L
Sbjct: 105 RAGRTALHEAAWHGHSRVAELL 126
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 84.3 bits (207), Expect = 1e-16
Identities = 61/200 (30%), Positives = 97/200 (48%), Gaps = 14/200 (7%)
Query: 13 AARAGQDDEVRILMANGAPFTTD----WLGTSPLHLAAQYGHYSTTEVLLRA-GVSRDAR 67
A + GQ++ VRIL+ G + WL PLH AA GH ++L + GVS +A+
Sbjct: 544 ACQHGQENIVRILLRRGVDVSLQGKDAWL---PLHYAAWQGHLPIVKLLAKQPGVSVNAQ 600
Query: 68 TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
T RTPLH+AA GH + +L+ +DVN +L T LH A E H LL+ G
Sbjct: 601 TLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRG 660
Query: 128 ADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTI-----HAATPQ 182
A + TA ++ NG+ ++L + + P + + + H+ +
Sbjct: 661 AGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVE 720
Query: 183 FIIGPGGVVNLTDETGVSAV 202
++ V++L DE G+SA+
Sbjct: 721 ELVS-ADVIDLFDEQGLSAL 739
Score = 77.0 bits (188), Expect = 2e-14
Identities = 55/179 (30%), Positives = 90/179 (50%), Gaps = 5/179 (2%)
Query: 4 VDLGKKLLE-AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAG 61
+D G LL A AGQ++ + L+ N A P ++ G++PLH+A + E+LL
Sbjct: 435 LDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARK 494
Query: 62 VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE 121
+S +A+ + T LH AA G S +LL+ A VN D T +H A +H + +V
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
Query: 122 LLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAA 179
+L++ G DV Q K + G+ + ++L A Q ++ N ++ D T +H A
Sbjct: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL--AKQPGVSVNAQTLDGRTPLHLA 611
Score = 74.7 bits (182), Expect = 1e-13
Identities = 45/130 (34%), Positives = 63/130 (48%), Gaps = 32/130 (24%)
Query: 37 LGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGAD 96
L +PLH+AA+ GH ST +LL G ++A T T LH+AA GH + V++L++ AD
Sbjct: 636 LAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKAD 695
Query: 97 VNAKDMLKMTALHWATEHNHQEVVE--------------------------------LLI 124
V A+ L TALH A H H EVVE L+
Sbjct: 696 VLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLL 755
Query: 125 KYGADVHTQS 134
++GA ++ QS
Sbjct: 756 RHGAHINLQS 765
Score = 50.1 bits (118), Expect = 3e-06
Identities = 34/91 (37%), Positives = 47/91 (51%), Gaps = 2/91 (2%)
Query: 13 AARAGQDDEVRILMANGAPFTTDW-LGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G V++L+ A L + LHLAA +GH E L+ A V D +
Sbjct: 677 AARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVI-DLFDEQG 735
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDM 102
+ LH+AA HA VE LL+HGA +N + +
Sbjct: 736 LSALHLAAQGRHAQTVETLLRHGAHINLQSL 766
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 84.0 bits (206), Expect = 2e-16
Identities = 54/147 (36%), Positives = 78/147 (53%), Gaps = 3/147 (2%)
Query: 13 AARAGQDDEVRILMANGAPFTTDWLGTS-PLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA G+ D + +L+ +GA + PLHLA Q GH+ + LL + + +
Sbjct: 751 AALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSG 810
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL A S GH +V +LL+HGA +NA + TALH A H VVELL+ +GA V
Sbjct: 811 NTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQ 870
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQI 158
+K +TA D + N + E+LQ+
Sbjct: 871 VLNKRQRTAVDCA--EQNSKIMELLQV 895
Score = 74.7 bits (182), Expect = 1e-13
Identities = 40/119 (33%), Positives = 64/119 (53%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G+SPLH+AA +G +LL+ G + AR PLH+A +GH +V+ LL A
Sbjct: 744 GSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKP 803
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
N KD+ T L +A H E+V LL+++GA ++ + TA ++ + + E+L
Sbjct: 804 NKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELL 862
Score = 72.4 bits (176), Expect = 6e-13
Identities = 49/182 (26%), Positives = 89/182 (48%), Gaps = 11/182 (6%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA GQ + +L++ GA TD+ G +PLHLA Q G+ S T +LL S + +
Sbjct: 470 AAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNG 529
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKM---TALHWATEHNHQEVVELLIKYGA 128
TPLH+A + GH V+ L+ + + D+ T LH A +Q V+E L++ GA
Sbjct: 530 NTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGA 589
Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQ-------INTNPESPDTVTIHAATP 181
Q++ +T ++++ + E ++ + + + + S D+++ ++T
Sbjct: 590 STEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTS 649
Query: 182 QF 183
F
Sbjct: 650 SF 651
Score = 62.4 bits (150), Expect = 6e-10
Identities = 33/99 (33%), Positives = 53/99 (53%)
Query: 31 PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVL 90
PF+ D G +PLH+AA G S ++L+ G +A TPLH+A +G+ S+ +L
Sbjct: 456 PFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLL 515
Query: 91 LKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
L + A +D T LH A + H++ V+ L+ Y +
Sbjct: 516 LHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVE 554
Score = 58.9 bits (141), Expect = 6e-09
Identities = 36/94 (38%), Positives = 49/94 (52%), Gaps = 3/94 (3%)
Query: 63 SRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVEL 122
SRD R TPLH+AA G AS++++L+ GA VNA D T LH A + +Q V L
Sbjct: 458 SRDDR---GHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLL 514
Query: 123 LIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
L+ Y A Q T ++ G+ED + L
Sbjct: 515 LLHYKASAEVQDNNGNTPLHLACTYGHEDCVKAL 548
Score = 58.5 bits (140), Expect = 8e-09
Identities = 39/177 (22%), Positives = 78/177 (44%), Gaps = 5/177 (2%)
Query: 60 AGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEV 119
+G+ + ++ +PLH+AA G A ++ +LLKHGA+ A++ + LH A + H +V
Sbjct: 733 SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQV 792
Query: 120 VELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL-----QIAMQNQINTNPESPDTV 174
V+ L+ A + + T + G+ +L +L I N +
Sbjct: 793 VKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVI 852
Query: 175 TIHAATPQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSET 231
H + ++ G V + ++ +AV ++ ++ L + A L + +ET
Sbjct: 853 EKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAET 909
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 83.6 bits (205), Expect = 2e-16
Identities = 65/223 (29%), Positives = 102/223 (45%), Gaps = 34/223 (15%)
Query: 10 LLEAARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L AA G+ + +L+ +GA + T+ G PL AA+ GH+ +LL G +
Sbjct: 1075 LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSD 1134
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
K RTPL +AA EGH S VE LL GA +++ D ++AL WA H+ VV+ L++ GA
Sbjct: 1135 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGA 1194
Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPG 188
+ K +T D++ G+ A T +++ G
Sbjct: 1195 AIDQTDKNGRTPLDLAAFYGD----------------------------AETVLYLVEKG 1226
Query: 189 GVVNLTDETGVSAVQ--FGNSSTSVLATLAALAEASAPLSNSS 229
V+ D +G+ + G +TSV + AL A L N++
Sbjct: 1227 AVIEHVDHSGMRPLDRAIGCRNTSV---VVALLRKGAKLGNAA 1266
Score = 43.5 bits (101), Expect = 3e-04
Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 13/149 (8%)
Query: 36 WLGTSPLHLAAQYG--------HYSTTEVLLRAGVSRDARTKV-DRTPLHMAASE-GHAS 85
W+G S L+A + + +L+ G + + RT+V + P+ S GH
Sbjct: 882 WIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEE 941
Query: 86 IVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISI 145
+V +LL+ GA ++ MTAL +A H ++V LL K G V K + A S
Sbjct: 942 VVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSA 1001
Query: 146 DNGNEDLAEILQIAMQNQINTNPESPDTV 174
G+ D ILQ + + + P P T+
Sbjct: 1002 LRGHGD---ILQYLLTCEWSPGPPQPGTL 1027
Score = 41.6 bits (96), Expect = 0.001
Identities = 30/105 (28%), Positives = 50/105 (47%), Gaps = 3/105 (2%)
Query: 23 RILMANGAP--FTTDWLGTSP-LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAA 79
R+L+ GA + T+ L +P L + + GH +LL G D ++ T L AA
Sbjct: 909 RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968
Query: 80 SEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLI 124
+ GH +V +L K G V+ D AL + H ++++ L+
Sbjct: 969 AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLL 1013
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 83.6 bits (205), Expect = 2e-16
Identities = 65/223 (29%), Positives = 102/223 (45%), Gaps = 34/223 (15%)
Query: 10 LLEAARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L AA G+ + +L+ +GA + T+ G PL AA+ GH+ +LL G +
Sbjct: 1083 LTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSD 1142
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
K RTPL +AA EGH S VE LL GA +++ D ++AL WA H+ VV+ L++ GA
Sbjct: 1143 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGA 1202
Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPG 188
+ K +T D++ G+ A T +++ G
Sbjct: 1203 AIDQTDKNGRTPLDLAAFYGD----------------------------AETVLYLVEKG 1234
Query: 189 GVVNLTDETGVSAVQ--FGNSSTSVLATLAALAEASAPLSNSS 229
V+ D +G+ + G +TSV + AL A L N++
Sbjct: 1235 AVIEHVDHSGMRPLDRAIGCRNTSV---VVALLRKGAKLGNAA 1274
Score = 43.5 bits (101), Expect = 3e-04
Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 13/149 (8%)
Query: 36 WLGTSPLHLAAQYG--------HYSTTEVLLRAGVSRDARTKV-DRTPLHMAASE-GHAS 85
W+G S L+A + + +L+ G + + RT+V + P+ S GH
Sbjct: 890 WIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEE 949
Query: 86 IVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISI 145
+V +LL+ GA ++ MTAL +A H ++V LL K G V K + A S
Sbjct: 950 VVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSA 1009
Query: 146 DNGNEDLAEILQIAMQNQINTNPESPDTV 174
G+ D ILQ + + + P P T+
Sbjct: 1010 LRGHGD---ILQYLLTCEWSPGPPQPGTL 1035
Score = 41.6 bits (96), Expect = 0.001
Identities = 30/105 (28%), Positives = 50/105 (47%), Gaps = 3/105 (2%)
Query: 23 RILMANGAP--FTTDWLGTSP-LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAA 79
R+L+ GA + T+ L +P L + + GH +LL G D ++ T L AA
Sbjct: 917 RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976
Query: 80 SEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLI 124
+ GH +V +L K G V+ D AL + H ++++ L+
Sbjct: 977 AAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLL 1021
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 83.6 bits (205), Expect = 2e-16
Identities = 65/239 (27%), Positives = 109/239 (45%), Gaps = 15/239 (6%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L A + ++ V++L+ + A D +PLH+AA E L+ + +
Sbjct: 78 LHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSD 137
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
+ RT LH AA GH +V++LL GA++NA D A+HWA H EVV+LL+ +GA
Sbjct: 138 RAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197
Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTN-PESPDTVTIHAA-------T 180
+V + K T + +G + +++ + ++ N P + +H A
Sbjct: 198 EVTCKDKKSYTPLHAAASSG---MISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVV 254
Query: 181 PQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPL---SNSSETPVVAT 236
+I G +VN +E G + + F +ST L L A + S +TP+ T
Sbjct: 255 VNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMT 313
Score = 79.7 bits (195), Expect = 4e-15
Identities = 59/201 (29%), Positives = 95/201 (47%), Gaps = 10/201 (4%)
Query: 40 SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNA 99
SPLHLAA +GH+ EVL+++ + D R RTPL +AA +GH V+VL+ GA +
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
Query: 100 KD-MLKMTALHWATEHNHQEVVELLIKYGAD---VHTQSKFCKTAFDISIDNGNEDLAEI 155
KD +LK T +H A + H E + LLI V Q +T +S+ NG+ D
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
Query: 156 L-----QIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTDETGVSAVQFGNSSTS 210
L + +++ VT H ++ G L D G + + +++
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHL-SAACG 730
Query: 211 VLATLAALAEASAPLSNSSET 231
+ L AL +++A + + T
Sbjct: 731 HIGVLGALLQSAASMDANPAT 751
Score = 77.4 bits (189), Expect = 2e-14
Identities = 81/330 (24%), Positives = 124/330 (37%), Gaps = 66/330 (20%)
Query: 13 AARAGQDDEVRILMANGAPFTT----DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
AA G + +R+L+ N P D G +PL L+ GH LL G + DA+
Sbjct: 624 AATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKD 683
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGA--------------------------------- 95
K RT LH A GH V+ LL+HGA
Sbjct: 684 KWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAA 743
Query: 96 --DVN--AKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNED 151
D N D TALHWA + H+ VELL++ T+ + ++ N NE
Sbjct: 744 SMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGN-AFSPLHCAVINDNEG 802
Query: 152 LAEILQIAMQNQINTNPESPDTVTIHAAT-------PQFIIGPGGVVNLTDETGVSAVQF 204
AE+L + I +S +HAA Q ++ VN D TG + +
Sbjct: 803 AAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMM 862
Query: 205 G--NSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVIT 262
N T+ + L + A A L ++S+ + A+ S G +
Sbjct: 863 AAENGQTNTVEMLVSSASAELTLQDNSK---------------NTALHLACSKGHETSAL 907
Query: 263 IVTDGIQLGNLHSIPTSGIGQPIIVTMPDG 292
++ + I NL + + + P+ V +G
Sbjct: 908 LILEKITDRNLINATNAALQTPLHVAARNG 937
Score = 74.7 bits (182), Expect = 1e-13
Identities = 48/193 (24%), Positives = 85/193 (44%), Gaps = 6/193 (3%)
Query: 22 VRILMANGAPFTTDWL-GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAAS 80
+ +L+ NGA G +PLH+ A +G +S ++ ++++G D K TPLH+AA
Sbjct: 289 LELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAAR 348
Query: 81 EGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTA 140
GH ++ L+ GAD + + M LH A + L+ G D+ T F +T
Sbjct: 349 YGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTC 408
Query: 141 FDISIDNGNEDLAEIL-----QIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTD 195
+ GN + +L +++ +P + ++G G VN D
Sbjct: 409 LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD 468
Query: 196 ETGVSAVQFGNSS 208
E G + + + +S
Sbjct: 469 ERGCTPLHYAATS 481
Score = 69.7 bits (169), Expect = 4e-12
Identities = 71/256 (27%), Positives = 112/256 (43%), Gaps = 19/256 (7%)
Query: 10 LLEAARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L++A G DEVR L+ D +PLH AA G E+L+ +G +A+
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 71
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
TPLH A + V+VLLKH ADVNA+D T LH A + + E L+ +
Sbjct: 72 SKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLS 131
Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNP-ESPDTVTIHAA-------T 180
+V+ + +TA + +G+ E++++ + N N + D IH A
Sbjct: 132 NVNVSDRAGRTALHHAAFSGH---GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEV 188
Query: 181 PQFIIGPGGVVNLTDETGVSAVQFGNSS--TSVLATLAALAEASAPLSNSSETPVVAT-- 236
+ ++ G V D+ + + SS SV+ L L + TP+
Sbjct: 189 VKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACY 248
Query: 237 --EEVVTAESVD-GAI 249
++VV E +D GAI
Sbjct: 249 NGQDVVVNELIDCGAI 264
Score = 68.9 bits (167), Expect = 6e-12
Identities = 64/225 (28%), Positives = 97/225 (43%), Gaps = 13/225 (5%)
Query: 17 GQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRA-GVSR-DARTKVDRTP 74
G + V +L+ T+ SPLH A + E+L+ G S +A RTP
Sbjct: 767 GHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTP 826
Query: 75 LHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG-ADVHTQ 133
LH AA H +++LL H A VN+ D T L A E+ VE+L+ A++ Q
Sbjct: 827 LHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQ 886
Query: 134 SKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESPDTVTIHAATP-------QFI 184
TA ++ G+E A ++ +I +N IN + T +H A Q +
Sbjct: 887 DNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQT-PLHVAARNGLTMVVQEL 945
Query: 185 IGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSS 229
+G G V DE G + + V LA + P+S+SS
Sbjct: 946 LGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSS 990
Score = 58.5 bits (140), Expect = 8e-09
Identities = 43/146 (29%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AA +G V+ L+ G + G +PLH+A G L+ G + + +
Sbjct: 213 AASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKG 272
Query: 72 RTPLHMAASEGHASI-VEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADV 130
TPLH AA+ H ++ +E+L+ +GADVN K T LH H + +I+ GA +
Sbjct: 273 FTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVI 332
Query: 131 HTQSKFCKTAFDISIDNGNEDLAEIL 156
+ K T I+ G+E L L
Sbjct: 333 DCEDKNGNTPLHIAARYGHELLINTL 358
Score = 54.7 bits (130), Expect = 1e-07
Identities = 51/203 (25%), Positives = 91/203 (44%), Gaps = 22/203 (10%)
Query: 25 LMANGA-PFTTDWLGTSPLHLAAQYGHY---------STTEVLLRAG---VSRDARTKVD 71
L+ N A P D G + +H +A YGH + +VL+ + D+ +
Sbjct: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
+PLH+AA GH +EVL++ D++ ++ T L A H E V++LI GA +
Sbjct: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
Query: 132 TQSKFCK-TAFDISIDNGNEDLAEIL--QIAMQNQINT---NPESPDTVTI---HAATPQ 182
+ K T + NG+ + +L QN ++ N ++P +++ H
Sbjct: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
Query: 183 FIIGPGGVVNLTDETGVSAVQFG 205
++ G V+ D+ G +A+ G
Sbjct: 671 SLLNKGANVDAKDKWGRTALHRG 693
Score = 51.2 bits (121), Expect = 1e-06
Identities = 61/265 (23%), Positives = 106/265 (40%), Gaps = 60/265 (22%)
Query: 5 DLGKKLLEAARAGQDDE-VRILMANGAPFTT-DWLGTSPLHLAA---------------- 46
D G+ L AA AG + E + +L+ GA F D G SPLH AA
Sbjct: 403 DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGA 462
Query: 47 ------QYG----HYSTT--------EVLLRAGVSRDARTKVDRTPLHMAASEGHASIVE 88
+ G HY+ T E LLR + R K +H +A+ GH ++
Sbjct: 463 SVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQ 522
Query: 89 VLLKHG-----ADVNAKDMLK-------MTALHWATEHNHQEVVELLIKYGADVHTQSKF 136
++ + + DML ++ LH A H H + +E+L++ D+ ++
Sbjct: 523 LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSS 582
Query: 137 CKTAFDISIDNGNEDLAEIL-----QIAMQNQI-NTNPESPDTVTIHAATPQFIIGPGGV 190
+T D++ G+ + ++L I +++ I P H+ + +IG
Sbjct: 583 GRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEP 642
Query: 191 VNLTDETGVSAVQFGNSSTSVLATL 215
N D +Q GN T ++ ++
Sbjct: 643 QNAVD------IQDGNGQTPLMLSV 661
Score = 45.4 bits (106), Expect = 7e-05
Identities = 41/139 (29%), Positives = 65/139 (46%), Gaps = 6/139 (4%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTT--DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRD-- 65
L+ AA GQ + V +L+++ + T D + LHLA GH ++ ++L R+
Sbjct: 860 LMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLI 919
Query: 66 -ARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMT-ALHWATEHNHQEVVELL 123
A +TPLH+AA G +V+ LL GA V A D T AL A + + + L+
Sbjct: 920 NATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALI 979
Query: 124 IKYGADVHTQSKFCKTAFD 142
+ V + S F+
Sbjct: 980 LATMMPVSSSSPLSSLTFN 998
Score = 38.5 bits (88), Expect = 0.009
Identities = 26/86 (30%), Positives = 40/86 (46%)
Query: 71 DRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADV 130
D+ L A G V L+ DVN +D K T LH A E++ELLI GA V
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 131 HTQSKFCKTAFDISIDNGNEDLAEIL 156
+ + T ++ + +E+ ++L
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVL 93
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 81.6 bits (200), Expect = 9e-16
Identities = 49/138 (35%), Positives = 73/138 (52%), Gaps = 1/138 (0%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G D ++L + G+ P D +PLH AA +G+YS + L AG + + + +
Sbjct: 452 AARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREG 511
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPL A++ G+ IVE L +HGAD+NA D ALH A EV++ L+ G V
Sbjct: 512 ETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVD 571
Query: 132 TQSKFCKTAFDISIDNGN 149
Q + T ++ +GN
Sbjct: 572 YQDRHGNTPLHVACKDGN 589
Score = 75.9 bits (185), Expect = 5e-14
Identities = 44/134 (32%), Positives = 71/134 (52%), Gaps = 1/134 (0%)
Query: 13 AARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G D ++ L N P D G LH+AA+YGH ++L G + + + K +
Sbjct: 419 AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE 478
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
TPLH AA G+ S+ + L + G +VN K+ T L A+ + ++VE L ++GAD++
Sbjct: 479 ETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLN 538
Query: 132 TQSKFCKTAFDISI 145
K A +++
Sbjct: 539 ACDKDGHIALHLAV 552
Score = 66.2 bits (160), Expect = 4e-11
Identities = 42/148 (28%), Positives = 74/148 (50%), Gaps = 1/148 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
LL AA G +++L+ G+ D G++ ++ AA++GH T + L D +
Sbjct: 383 LLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKD 442
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
K LH+AA GHA + ++L G++ N +D + T LH A H + V + L + G
Sbjct: 443 KSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGC 502
Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+V+ +++ +T + G D+ E L
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVECL 530
Score = 59.7 bits (143), Expect = 4e-09
Identities = 45/148 (30%), Positives = 67/148 (45%), Gaps = 1/148 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
LL A+ G D V L +GA D G LHLA + + LL G D +
Sbjct: 515 LLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQD 574
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
+ TPLH+A +G+ IV L + +++ + T LH A + +VV L GA
Sbjct: 575 RHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGA 634
Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEIL 156
V + KTA D++ +E +A +L
Sbjct: 635 SVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 58.2 bits (139), Expect = 1e-08
Identities = 39/120 (32%), Positives = 54/120 (45%), Gaps = 1/120 (0%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
A R Q + ++ L++ G D G +PLH+A + G+ L A + D K
Sbjct: 551 AVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYG 610
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
RTPLH+AA+ G +V L GA V A TA A H+ V LL + D H
Sbjct: 611 RTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTH 670
Score = 57.0 bits (136), Expect = 2e-08
Identities = 33/119 (27%), Positives = 60/119 (50%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
GT PL +AA G+ ++L++ G D + K ++ AA GH ++ L ++ +
Sbjct: 379 GTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPL 438
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+ KD ALH A + H +V +LL +G++ + Q K +T + +G +A+ L
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL 497
>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
Length = 360
Score = 81.6 bits (200), Expect = 9e-16
Identities = 47/129 (36%), Positives = 67/129 (51%), Gaps = 1/129 (0%)
Query: 45 AAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLK 104
AA G E L G S D + RT LH A+ EGH I+E LL +GA V+ +D L
Sbjct: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
Query: 105 MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQI 164
TA+HWA H EVV+LL +GAD + + K T +++ G ++ E +++ +I
Sbjct: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF-LSLGLEI 273
Query: 165 NTNPESPDT 173
N DT
Sbjct: 274 NARDREGDT 282
Score = 74.3 bits (181), Expect = 1e-13
Identities = 46/135 (34%), Positives = 71/135 (52%), Gaps = 1/135 (0%)
Query: 10 LLEAARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L A+ G + + L+ NGA D L + +H A + GH ++L G + R
Sbjct: 185 LHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRD 244
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
K+ TPLH+A G IVE L G ++NA+D TALH A N ++++LL+ +GA
Sbjct: 245 KLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGA 304
Query: 129 DVHTQSKFCKTAFDI 143
D+ T++ KT D+
Sbjct: 305 DMMTKNLAGKTPTDL 319
Score = 72.8 bits (177), Expect = 4e-13
Identities = 45/158 (28%), Positives = 76/158 (48%), Gaps = 1/158 (0%)
Query: 11 LEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
L+AA G+ + +A+G T D + LH A+ GH E LL G + D + +
Sbjct: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
+D T +H A GH +V++L HGAD N +D L T LH A E+VE + G +
Sbjct: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLE 272
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTN 167
++ + + TA ++ + ++L + + + N
Sbjct: 273 INARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKN 310
Score = 49.7 bits (117), Expect = 4e-06
Identities = 28/88 (31%), Positives = 43/88 (48%)
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
VD AA EG ++E L G + D + TALH A+ H E++E L+ GA
Sbjct: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQ 157
V Q + TA + G+ ++ ++LQ
Sbjct: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQ 234
>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
Length = 305
Score = 81.6 bits (200), Expect = 9e-16
Identities = 55/164 (33%), Positives = 83/164 (50%), Gaps = 6/164 (3%)
Query: 11 LEAARAGQDDEV-RILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
L+AA Q+ + + L G P D L + LH A GH LL AG + DAR
Sbjct: 116 LKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDL 175
Query: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
+DRTP+ A GH I++ LL GA VNA+D + T LH A H + +E LI+ GA
Sbjct: 176 LDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAH 235
Query: 130 VHTQSKFCKTAFDISIDNGNEDLAEIL-----QIAMQNQINTNP 168
++ Q K TA ++ +G+ ++L ++ ++N + P
Sbjct: 236 LNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTP 279
Score = 70.5 bits (171), Expect = 2e-12
Identities = 40/124 (32%), Positives = 65/124 (52%)
Query: 23 RILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEG 82
++L+A D L +P+ A + GH + LL G +AR K+ TPLH+A
Sbjct: 162 KLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTR 221
Query: 83 HASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFD 142
H +E L++ GA +NA+D TALH A H + ++LL+ YGA++ ++ T
Sbjct: 222 HPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQ 281
Query: 143 ISID 146
++ D
Sbjct: 282 LARD 285
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 80.9 bits (198), Expect = 2e-15
Identities = 51/153 (33%), Positives = 78/153 (50%), Gaps = 9/153 (5%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G LHLAA GH+ ++LL AG +A T + TPL +A G ++ +LL+HGA+V
Sbjct: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
Query: 98 N-AKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
N + M +LH A+ + E+++LL++ GA+ Q F T ++ G E L
Sbjct: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK---LESL 122
Query: 157 QIAMQNQINTNPESPDTVTIHAATPQFIIGPGG 189
I + + N N ++ D ATP FI G
Sbjct: 123 SILISSGANVNCQALD-----KATPLFIAAQEG 150
Score = 63.9 bits (154), Expect = 2e-10
Identities = 40/122 (32%), Positives = 64/122 (52%), Gaps = 2/122 (1%)
Query: 10 LLEAARAGQDDEVRILMANGAPF--TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDAR 67
L A GQ D +R+L+ +GA + G + LH A+ + ++LLR G +++ +
Sbjct: 43 LFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQ 102
Query: 68 TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
TPL +AA G + +L+ GA+VN + + K T L A + H + VELL+ G
Sbjct: 103 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSG 162
Query: 128 AD 129
AD
Sbjct: 163 AD 164
Score = 59.7 bits (143), Expect = 4e-09
Identities = 44/146 (30%), Positives = 73/146 (50%), Gaps = 2/146 (1%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVS-RDARTKV 70
AA G V+IL+ GA P T T+PL LA + G +LL+ G + + +
Sbjct: 13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 72
Query: 71 DRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADV 130
LH A+ + +A I+++LL+ GA+ +D +T L A ++ E + +LI GA+V
Sbjct: 73 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 132
Query: 131 HTQSKFCKTAFDISIDNGNEDLAEIL 156
+ Q+ T I+ G+ E+L
Sbjct: 133 NCQALDKATPLFIAAQEGHTKCVELL 158
Score = 56.2 bits (134), Expect = 4e-08
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 3/128 (2%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLG-TSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L AA+ G+ + + IL+++GA L +PL +AAQ GH E+LL +G D
Sbjct: 110 LFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYC 169
Query: 69 KVD--RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKY 126
D + P+H AA GH I+++L+ + K++ ++ A H++ +E+L++
Sbjct: 170 NEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRN 229
Query: 127 GADVHTQS 134
G Q+
Sbjct: 230 GYSPDAQA 237
Score = 46.6 bits (109), Expect = 3e-05
Identities = 35/137 (25%), Positives = 68/137 (49%), Gaps = 10/137 (7%)
Query: 4 VDLGKKLLEAARAGQDDEVRILMANGAP---FTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
+D L AA+ G V +L+++GA + + P+H AAQ GH ++L+
Sbjct: 137 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPL 196
Query: 61 GVSRDARTKVDR-TPLHMAASEGHASIVEVLLKHGADVNAKDML-----KMTALHWATEH 114
+R T +++ +P++ A GH +E+LL++G +A+ L + + +
Sbjct: 197 -TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDC 255
Query: 115 NHQEVVELLIKYGADVH 131
+V +L+KYGA ++
Sbjct: 256 EFFGIVNILLKYGAQIN 272
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 80.9 bits (198), Expect = 2e-15
Identities = 51/153 (33%), Positives = 78/153 (50%), Gaps = 9/153 (5%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G LHLAA GH+ ++LL AG +A T + TPL +A G ++ +LL+HGA+V
Sbjct: 79 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 138
Query: 98 N-AKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
N + M +LH A+ + E+++LL++ GA+ Q F T ++ G E L
Sbjct: 139 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK---LESL 195
Query: 157 QIAMQNQINTNPESPDTVTIHAATPQFIIGPGG 189
I + + N N ++ D ATP FI G
Sbjct: 196 SILISSGANVNCQALD-----KATPLFIAAQEG 223
Score = 63.9 bits (154), Expect = 2e-10
Identities = 40/122 (32%), Positives = 64/122 (52%), Gaps = 2/122 (1%)
Query: 10 LLEAARAGQDDEVRILMANGAPF--TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDAR 67
L A GQ D +R+L+ +GA + G + LH A+ + ++LLR G +++ +
Sbjct: 116 LFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQ 175
Query: 68 TKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYG 127
TPL +AA G + +L+ GA+VN + + K T L A + H + VELL+ G
Sbjct: 176 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSG 235
Query: 128 AD 129
AD
Sbjct: 236 AD 237
Score = 59.7 bits (143), Expect = 4e-09
Identities = 44/146 (30%), Positives = 73/146 (50%), Gaps = 2/146 (1%)
Query: 13 AARAGQDDEVRILMANGA-PFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVS-RDARTKV 70
AA G V+IL+ GA P T T+PL LA + G +LL+ G + + +
Sbjct: 86 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 145
Query: 71 DRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADV 130
LH A+ + +A I+++LL+ GA+ +D +T L A ++ E + +LI GA+V
Sbjct: 146 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 205
Query: 131 HTQSKFCKTAFDISIDNGNEDLAEIL 156
+ Q+ T I+ G+ E+L
Sbjct: 206 NCQALDKATPLFIAAQEGHTKCVELL 231
Score = 56.2 bits (134), Expect = 4e-08
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 3/128 (2%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTDWLG-TSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
L AA+ G+ + + IL+++GA L +PL +AAQ GH E+LL +G D
Sbjct: 183 LFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYC 242
Query: 69 KVD--RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKY 126
D + P+H AA GH I+++L+ + K++ ++ A H++ +E+L++
Sbjct: 243 NEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRN 302
Query: 127 GADVHTQS 134
G Q+
Sbjct: 303 GYSPDAQA 310
Score = 52.8 bits (125), Expect = 5e-07
Identities = 52/195 (26%), Positives = 82/195 (42%), Gaps = 44/195 (22%)
Query: 32 FTTDWLGT-SPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTP---------------- 74
FT + T S + LAA+ G+ LL+ G S D P
Sbjct: 3 FTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQML 62
Query: 75 --------------------LHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEH 114
LH+AAS+GH IV++LL+ GAD NA + + T L A E+
Sbjct: 63 INADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVEN 122
Query: 115 NHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTV 174
+V+ LL+++GA+V+ C ++ ++ AEI+++ ++ N E D
Sbjct: 123 GQIDVLRLLLQHGANVNGSHSMC--GWNSLHQASFQENAEIIKLLLRK--GANKECQDDF 178
Query: 175 TIHAATPQFIIGPGG 189
I TP F+ G
Sbjct: 179 GI---TPLFVAAQYG 190
Score = 46.6 bits (109), Expect = 3e-05
Identities = 35/137 (25%), Positives = 68/137 (49%), Gaps = 10/137 (7%)
Query: 4 VDLGKKLLEAARAGQDDEVRILMANGAP---FTTDWLGTSPLHLAAQYGHYSTTEVLLRA 60
+D L AA+ G V +L+++GA + + P+H AAQ GH ++L+
Sbjct: 210 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPL 269
Query: 61 GVSRDARTKVDR-TPLHMAASEGHASIVEVLLKHGADVNAKDML-----KMTALHWATEH 114
+R T +++ +P++ A GH +E+LL++G +A+ L + + +
Sbjct: 270 -TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDC 328
Query: 115 NHQEVVELLIKYGADVH 131
+V +L+KYGA ++
Sbjct: 329 EFFGIVNILLKYGAQIN 345
Score = 41.2 bits (95), Expect = 0.001
Identities = 31/122 (25%), Positives = 53/122 (43%), Gaps = 15/122 (12%)
Query: 77 MAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD-----VH 131
+AA EG+ ++ LLK G V+ D +H A HN E +++LI + +
Sbjct: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
T FC A ++ G+ + +IL A P+ T+ TP F+ G +
Sbjct: 76 TFEGFC--ALHLAASQGHWKIVQILLEA--------GADPNATTLEETTPLFLAVENGQI 125
Query: 192 NL 193
++
Sbjct: 126 DV 127
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 80.5 bits (197), Expect = 2e-15
Identities = 69/278 (24%), Positives = 113/278 (40%), Gaps = 24/278 (8%)
Query: 38 GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV 97
G P LA+Q GHY ++LL + D R R L +AA EGH IVE+L HGADV
Sbjct: 880 GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADV 939
Query: 98 NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQ 157
N KD L+ N + E ++ GA+V +TA +S G+ ++ ++L
Sbjct: 940 NCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL- 998
Query: 158 IAMQNQINTNPESPDTVTI------HAATPQFIIGPGGVVNLTDETGVSAVQFGNSSTSV 211
IA +N + H Q +I G VV+ T G +A+ +
Sbjct: 999 IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHI 1058
Query: 212 LATLAALAEASAP-------------LSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQ 258
L + P + + + ++ E A S++G V + Q
Sbjct: 1059 DVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQ 1118
Query: 259 QVITIVTDGIQLGNLHSIPTSGIG----QPIIVTMPDG 292
+ + ++ +Q + S + G QP + +P+G
Sbjct: 1119 KPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNG 1156
Score = 77.4 bits (189), Expect = 2e-14
Identities = 78/262 (29%), Positives = 112/262 (42%), Gaps = 33/262 (12%)
Query: 13 AARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVD 71
AAR G V L+ GA TD G + L AA GH LL AGV D
Sbjct: 585 AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644
Query: 72 RTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVH 131
RT L AA GH IV LL+HGA+VN D TAL A H+E+VE L+ +GA+V+
Sbjct: 645 RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVN 704
Query: 132 TQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVV 191
+ +TA + A + A + HA+ +I G V
Sbjct: 705 HEDVDGRTALSV---------AALCVPASKG--------------HASVVSLLIDRGAEV 741
Query: 192 NLTDETGVSAVQFGNSSTSVLATLAALAEASAPL---SNSSETPVVATEEVVTAESVD-- 246
+ D+ G++ + V + L E A + N+ TP++A + A V+
Sbjct: 742 DHCDKDGMTPLLVAAYEGHV-DVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTL 800
Query: 247 ---GAIQQVVSSGGQQVITIVT 265
GA + S G+ V++I +
Sbjct: 801 LFWGAAVDSIDSEGRTVLSIAS 822
Score = 76.6 bits (187), Expect = 3e-14
Identities = 60/198 (30%), Positives = 88/198 (44%), Gaps = 12/198 (6%)
Query: 10 LLEAARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
LL AA G D V +L+ GA TD G +PL AA GH S LL G + D+
Sbjct: 752 LLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSID 811
Query: 69 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA 128
RT L +A+++G+ +V LL G D N +D T LH A H+ + E LI+ GA
Sbjct: 812 SEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGA 871
Query: 129 DVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPD--------TVTIHAAT 180
+ + F ++ G+ D +IL ++N+ N + D + H
Sbjct: 872 RTNEIDNDGRIPFILASQEGHYDCVQIL---LENKSNIDQRGYDGRNALRVAALEGHRDI 928
Query: 181 PQFIIGPGGVVNLTDETG 198
+ + G VN D G
Sbjct: 929 VELLFSHGADVNCKDADG 946
Score = 74.7 bits (182), Expect = 1e-13
Identities = 44/147 (29%), Positives = 79/147 (53%), Gaps = 1/147 (0%)
Query: 26 MANGAPF-TTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHA 84
+ NGA +D G + LH++ GH +VL+ +A R+ L AA +GH
Sbjct: 966 LENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHV 1025
Query: 85 SIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDIS 144
+V++L++HGA V+ TAL A + H +VV++L+++GAD + +F +TA ++
Sbjct: 1026 KVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVA 1085
Query: 145 IDNGNEDLAEILQIAMQNQINTNPESP 171
NG+ + ++L+ + +N SP
Sbjct: 1086 AKNGHSQIIKLLEKYGASSLNGCSPSP 1112
Score = 67.4 bits (163), Expect = 2e-11
Identities = 54/161 (33%), Positives = 75/161 (46%), Gaps = 3/161 (1%)
Query: 14 ARAGQDDEVRILMANGAPFT-TDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDR 72
A G V +L+ GA D G +PL +AA GH ++LL G D R
Sbjct: 723 ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782
Query: 73 TPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHT 132
TPL AAS GHAS+V LL GA V++ D T L A+ + EVV L+ G D +
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
Query: 133 QSKFCKTAFDISIDNGNEDLAEIL--QIAMQNQINTNPESP 171
+ T ++ G+ + E L Q A N+I+ + P
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIP 883
Score = 65.9 bits (159), Expect = 5e-11
Identities = 49/153 (32%), Positives = 71/153 (46%), Gaps = 6/153 (3%)
Query: 10 LLEAARAGQDDEVRILMANGAPFTTD------WLGTSPLHLAAQYGHYSTTEVLLRAGVS 63
L+ AA G + V L+ +GA + L + L + A GH S +L+ G
Sbjct: 681 LIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE 740
Query: 64 RDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELL 123
D K TPL +AA EGH +V++LL+ GADV+ D T L A H VV L
Sbjct: 741 VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTL 800
Query: 124 IKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL 156
+ +GA V + +T I+ GN ++ L
Sbjct: 801 LFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
Score = 65.1 bits (157), Expect = 9e-11
Identities = 59/213 (27%), Positives = 89/213 (41%), Gaps = 15/213 (7%)
Query: 18 QDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLH 76
++D +R L+ NGA D G + L AA G +L+ G + TPL
Sbjct: 524 REDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLT 583
Query: 77 MAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKF 136
+AA +GH +V L+ GA++N D TAL A H EVV L+ G V
Sbjct: 584 LAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD 643
Query: 137 CKTAFDISIDNGNEDLAEILQIAMQN-QINTNPESPDTVTI------HAATPQFIIGPGG 189
+TA + G+ED+ +L + ++N T I H + ++ G
Sbjct: 644 SRTALRAAAWGGHEDI--VLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGA 701
Query: 190 VVNLTDETGVSAVQFGNSSTSVLATLAALAEAS 222
VN D G +A+ S + L A+ AS
Sbjct: 702 EVNHEDVDGRTAL-----SVAALCVPASKGHAS 729
Score = 35.0 bits (79), Expect = 0.100
Identities = 39/166 (23%), Positives = 63/166 (37%), Gaps = 33/166 (19%)
Query: 55 EVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEH 114
++L++AG ++ DRT + + + LL +GA VN D T L A
Sbjct: 498 QLLVKAGAH--VNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYS 555
Query: 115 NHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTV 174
+VV LL+ GAD+ + T ++ G
Sbjct: 556 GSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQG-------------------------- 589
Query: 175 TIHAATPQFIIGPGGVVNLTDETGVSAVQ---FGNSSTSVLATLAA 217
H +IG G +N TD+ G +A++ +G + V A L A
Sbjct: 590 --HTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYA 633
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,365,432
Number of Sequences: 37866
Number of extensions: 516373
Number of successful extensions: 3910
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 360
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 1188
Number of HSP's gapped (non-prelim): 1568
length of query: 348
length of database: 18,247,518
effective HSP length: 103
effective length of query: 245
effective length of database: 14,347,320
effective search space: 3515093400
effective search space used: 3515093400
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.