Search of human proteins with 32307166

Search of human proteins with 32307166

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]
         (841 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]            1709   0.0  
gi|166197690 neuronal guanine nucleotide exchange factor isoform...   284   3e-76
gi|166197688 neuronal guanine nucleotide exchange factor isoform...   284   3e-76
gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]   270   5e-72
gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Hom...   257   3e-68
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]            248   2e-65
gi|194473700 Src homology 3 domain-containing guanine nucleotide...   242   9e-64
gi|24797153 faciogenital dysplasia protein [Homo sapiens]              96   2e-19
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                84   7e-16
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]    84   7e-16
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]    84   7e-16
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof...    79   1e-14
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo...    79   1e-14
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    79   2e-14
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    79   2e-14
gi|38373682 pleckstrin homology domain containing family G membe...    77   5e-14
gi|111154084 pleckstrin homology domain containing family G memb...    77   5e-14
gi|111154088 pleckstrin homology domain containing family G memb...    77   5e-14
gi|111154080 pleckstrin homology domain containing family G memb...    77   5e-14
gi|111154078 pleckstrin homology domain containing family G memb...    77   5e-14
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [...    77   7e-14
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [...    77   7e-14
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [...    77   7e-14
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    70   8e-12
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    70   8e-12
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo...    70   8e-12
gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like...    66   1e-10
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like...    66   1e-10
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...    65   2e-10
gi|222080070 pleckstrin homology domain-containing family G memb...    65   3e-10

>gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]
          Length = 841

 Score = 1709 bits (4426), Expect = 0.0
 Identities = 841/841 (100%), Positives = 841/841 (100%)

Query: 1   MSAQSLPAATPPTQKPPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTP 60
           MSAQSLPAATPPTQKPPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTP
Sbjct: 1   MSAQSLPAATPPTQKPPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTP 60

Query: 61  IFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRSASPEPAPRSPVPP 120
           IFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRSASPEPAPRSPVPP
Sbjct: 61  IFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRSASPEPAPRSPVPP 120

Query: 121 PKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEGRAQDADAPEPGLQARAD 180
           PKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEGRAQDADAPEPGLQARAD
Sbjct: 121 PKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEGRAQDADAPEPGLQARAD 180

Query: 181 VNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLELRWVPVGGYEEVPRVPRR 240
           VNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLELRWVPVGGYEEVPRVPRR
Sbjct: 181 VNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLELRWVPVGGYEEVPRVPRR 240

Query: 241 ASPLRTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFGDPPQPD 300
           ASPLRTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFGDPPQPD
Sbjct: 241 ASPLRTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFGDPPQPD 300

Query: 301 LDLLSEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLKEQNWELPLQDEPLYQTYRAAV 360
           LDLLSEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLKEQNWELPLQDEPLYQTYRAAV
Sbjct: 301 LDLLSEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLKEQNWELPLQDEPLYQTYRAAV 360

Query: 361 LSEELWGVGEDGSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERRMQE 420
           LSEELWGVGEDGSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERRMQE
Sbjct: 361 LSEELWGVGEDGSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERRMQE 420

Query: 421 SLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLL 480
           SLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLL
Sbjct: 421 SLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLL 480

Query: 481 SRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQS 540
           SRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQS
Sbjct: 481 SRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQS 540

Query: 541 LPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSA 600
           LPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSA
Sbjct: 541 LPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSA 600

Query: 601 EVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRFT 660
           EVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRFT
Sbjct: 601 EVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRFT 660

Query: 661 PLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPT 720
           PLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPT
Sbjct: 661 PLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPT 720

Query: 721 HRLLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSLESR 780
           HRLLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSLESR
Sbjct: 721 HRLLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSLESR 780

Query: 781 AAPKHLHKTPEGWLKGLPGAFPAQLVCEVTGEHERRRHLRQNQRLLEAVGSSSGTPNAPP 840
           AAPKHLHKTPEGWLKGLPGAFPAQLVCEVTGEHERRRHLRQNQRLLEAVGSSSGTPNAPP
Sbjct: 781 AAPKHLHKTPEGWLKGLPGAFPAQLVCEVTGEHERRRHLRQNQRLLEAVGSSSGTPNAPP 840

Query: 841 P 841
           P
Sbjct: 841 P 841


>gi|166197690 neuronal guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 618

 Score =  284 bits (726), Expect = 3e-76
 Identities = 170/465 (36%), Positives = 262/465 (56%), Gaps = 15/465 (3%)

Query: 370 EDGSPSPANAGDAPTFPR-----PPGPRNTLWQELPAVQASGLLDTLSPQERRMQESLFE 424
           E+    PA+  +  T P+      P  R  LWQ+LP +++SG+L+ L P+E ++QE++FE
Sbjct: 129 EEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFE 188

Query: 425 VVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVR 484
           +VTSEASY +SL LL   F+ ++ +R  L P + H LFSNV  V  VSERFL  L  R+ 
Sbjct: 189 LVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRME 248

Query: 485 SSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKC 544
            +  ISD+CD+V+ +A   FSVY+ YV NQ YQE TY +L+     F   + +L+  PKC
Sbjct: 249 ENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKC 308

Query: 545 ERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGR 604
             LP  SFL+LPFQRITRL++L+QNIL++ EE S R+  A  A   +  +++ C+  V +
Sbjct: 309 RGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRK 368

Query: 605 MKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRFTPLCL 664
           M +TE++I + +++ F K+K++P++S SR L  QGEL ++   +      ++  F  + L
Sbjct: 369 MSRTEQMISIQKKMEF-KIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYL 427

Query: 665 LLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSG--PPTFRLSLLSNHQGRPTHR 722
            LF+DLL+I +   G + QV D A R L++ +++ D        F L LL N   R    
Sbjct: 428 FLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATY 487

Query: 723 LLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSLESRAA 782
           +L+ASS S+M+RW+ +   P              DC Q  C       + +  +LE    
Sbjct: 488 MLKASSQSEMKRWMTSL-APNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADI 546

Query: 783 PKHLHKTPEGWLKG------LPGAFPAQLVCEVTGEHERRRHLRQ 821
              L KT +GW+ G        G FP+ +  E+     R ++L++
Sbjct: 547 LNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKE 591


>gi|166197688 neuronal guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 710

 Score =  284 bits (726), Expect = 3e-76
 Identities = 170/465 (36%), Positives = 262/465 (56%), Gaps = 15/465 (3%)

Query: 370 EDGSPSPANAGDAPTFPR-----PPGPRNTLWQELPAVQASGLLDTLSPQERRMQESLFE 424
           E+    PA+  +  T P+      P  R  LWQ+LP +++SG+L+ L P+E ++QE++FE
Sbjct: 221 EEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFE 280

Query: 425 VVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVR 484
           +VTSEASY +SL LL   F+ ++ +R  L P + H LFSNV  V  VSERFL  L  R+ 
Sbjct: 281 LVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRME 340

Query: 485 SSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKC 544
            +  ISD+CD+V+ +A   FSVY+ YV NQ YQE TY +L+     F   + +L+  PKC
Sbjct: 341 ENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKC 400

Query: 545 ERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGR 604
             LP  SFL+LPFQRITRL++L+QNIL++ EE S R+  A  A   +  +++ C+  V +
Sbjct: 401 RGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRK 460

Query: 605 MKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRFTPLCL 664
           M +TE++I + +++ F K+K++P++S SR L  QGEL ++   +      ++  F  + L
Sbjct: 461 MSRTEQMISIQKKMEF-KIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYL 519

Query: 665 LLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSG--PPTFRLSLLSNHQGRPTHR 722
            LF+DLL+I +   G + QV D A R L++ +++ D        F L LL N   R    
Sbjct: 520 FLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATY 579

Query: 723 LLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSLESRAA 782
           +L+ASS S+M+RW+ +   P              DC Q  C       + +  +LE    
Sbjct: 580 MLKASSQSEMKRWMTSL-APNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADI 638

Query: 783 PKHLHKTPEGWLKG------LPGAFPAQLVCEVTGEHERRRHLRQ 821
              L KT +GW+ G        G FP+ +  E+     R ++L++
Sbjct: 639 LNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKE 683


>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
          Length = 1597

 Score =  270 bits (689), Expect = 5e-72
 Identities = 188/537 (35%), Positives = 283/537 (52%), Gaps = 43/537 (8%)

Query: 323  PPATVEGREEEGLEVL---KEQNWELPLQDEPLYQTYRAAVLSEELWGVGEDGSPSPANA 379
            P  TV  RE++  EV+     +  +L    + LYQ Y   VL++E+       S S    
Sbjct: 1064 PSDTVVFREKKPKEVMGGFSRRCSKLINSSQLLYQEYSDVVLNKEIQSQQRLESLSETPG 1123

Query: 380  GDAPTFPRPP-------------GPRNTLWQELPAVQASGLLDTLSPQERRMQESLFEVV 426
              +P  PR                   +LWQE+P V+ S +L +++ +++++QE  FE++
Sbjct: 1124 PSSPRQPRKALVSSESYLQRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELI 1183

Query: 427  TSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVRSS 486
             SEASYLRSL +  D F LS +LR TL+ ++H  LFS +Q V+ VS  FL+ L     ++
Sbjct: 1184 VSEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENN 1243

Query: 487  PHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCER 546
                 +CDVV  HA     VY+ YV NQ YQE T+  LM++N  F   L +L+S P C+R
Sbjct: 1244 IFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQR 1303

Query: 547  LPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMK 606
            L L SFL+LPFQRITRL++LLQNIL++T+ GSS +  A KA  A+ ++I  C+  V  M+
Sbjct: 1304 LSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMR 1363

Query: 607  QTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTEL------GCRRGGVLFASRPRFT 660
            +TEELI L+Q++ F + K  PL+S SR L   GELT L      G RR       +    
Sbjct: 1364 RTEELIYLSQKIEF-ECKIFPLISQSRWLVKSGELTALEFSASPGLRR-------KLNTR 1415

Query: 661  PLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGPP---TFRLSLLSNHQG 717
            P+ L LF+D LL+++P+ G R  V D+A  S ++ ++       P    FRL L  N QG
Sbjct: 1416 PVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEKCEMKLHGPHKNLFRLFLRQNTQG 1475

Query: 718  RPTHRLLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSL 777
                 L +  + S+  RW+ A      +P     + E  +  Q  C  +  P + +  +L
Sbjct: 1476 AQAEFLFRTETQSEKLRWISAL----AMPREELDLLECYNSPQVQCLRAYKPRENDELAL 1531

Query: 778  ESRAAPKHLHKTPEGWLKGL------PGAFPAQLVCEVTGEHERRRHLRQNQRLLEA 828
            E         ++ +GWL+G+       G FP Q V  ++    R ++L++  R+  A
Sbjct: 1532 EKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVEFISNPEVRAQNLKEAHRVKTA 1588



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 52/218 (23%), Positives = 78/218 (35%), Gaps = 26/218 (11%)

Query: 6    LPAATPPTQKPPRIIRPRPPSRS-RAAQSPGPPHNGSSPQ------ELPRNSNDAPTPMC 58
            LP   PPT+ PP   + R  SRS R        H  + P        LP ++     P  
Sbjct: 842  LPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPA 901

Query: 59   TPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTP---SPVSRRSAS----PE 111
            T    E   ++ +  + + P  + +++ +   P SP++  TP    P S+  A     PE
Sbjct: 902  TARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPE 961

Query: 112  PAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSAS-------APGTVRRLAGRFEGGAEGR 164
               R P+    P      P     G   Q    S       +    RR +GR  G + G+
Sbjct: 962  APAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHRRDSGRPPGDSSGQ 1021

Query: 165  AQDADAPEPGLQARA--DVNGEREAPLTGSGSQENGAP 200
            A    AP  G          G R   +   GS ++  P
Sbjct: 1022 AV---APSEGANKHKGWSRQGLRRPSILPEGSSDSRGP 1056



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 26/105 (24%), Positives = 38/105 (36%), Gaps = 4/105 (3%)

Query: 47  PRNSNDAPTPMCTPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSPVSRR 106
           PR  + AP          P + S +PP   P   +  +  +  +  +P S   PSP    
Sbjct: 512 PRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAPLSMDDPSP---- 567

Query: 107 SASPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVR 151
             + E  P +    P    SP  P     G +    S S PG+ R
Sbjct: 568 CGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHR 612


>gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Homo
           sapiens]
          Length = 802

 Score =  257 bits (657), Expect = 3e-68
 Identities = 176/487 (36%), Positives = 258/487 (52%), Gaps = 17/487 (3%)

Query: 363 EELWGVGEDGSPSPANAGDAPTFPRPPGPRNT---LWQELPAVQASGLLDTLSPQERRMQ 419
           +E  G  E   P  AN   + +F      R +   LWQ++P V+ SG+L TLS ++ ++Q
Sbjct: 319 DEAEGAEEGPGPPRANLSPSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLRDCKLQ 378

Query: 420 ESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATL 479
           E+ FE++TSEASY+ SL +    F+ S  L + L  +D   LFS +  V+  SERFL  L
Sbjct: 379 EAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFLQDL 438

Query: 480 LSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQ 539
             R+ +      +CDVV  H      VY+ YV NQ YQE TY RL+  N RF   L RL+
Sbjct: 439 EQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLE 498

Query: 540 SLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCS 599
             P C+RLPL SFL+LPFQRITRL+ML++NIL++T +GS  ++ A KA  A+ ++++ C+
Sbjct: 499 ESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECN 558

Query: 600 AEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRF 659
           A V  MK+TEELI L++++ F + K  PL+S +R L   GEL EL           +   
Sbjct: 559 ASVQSMKRTEELIHLSKKIHF-EGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSS 617

Query: 660 TPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVP-DPSGPP--TFRLSLLSNHQ 716
             + L LF+D LL+++ K   +  V  +A  + +Q + +     G P   F L LL  H 
Sbjct: 618 KAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLSLKLQGIPGHVFLLQLL--HG 675

Query: 717 GRPTHR-LLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGR 775
               H+ LL+A + S+ QRW+ A     P     + I E  DC Q  C  +      +  
Sbjct: 676 QHMKHQFLLRARTESEKQRWISALCPSSPQE-DKEVISEGEDCPQVQCVRTYKALHPDEL 734

Query: 776 SLESRAAPKHLHKTPEGWLKGL------PGAFPAQLVCEVTGEHERRRHLRQNQRLLEAV 829
           +LE          T +GWL+G+       G  P   V E++    R R+LR+N+R+  A 
Sbjct: 735 TLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVEEISSLSARLRNLRENKRVTSAT 794

Query: 830 GSSSGTP 836
                 P
Sbjct: 795 SKLGEAP 801


>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
          Length = 709

 Score =  248 bits (633), Expect = 2e-65
 Identities = 146/384 (38%), Positives = 217/384 (56%), Gaps = 21/384 (5%)

Query: 370 EDGSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERRMQESLFEVVTSE 429
           E  SP      DA    +   P    W +LP V   G+LD LS +ER+ QE++FE++TSE
Sbjct: 237 ESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSE 296

Query: 430 ASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVRSSPHI 489
            SY  SL +L + F+ S+ LR T+T  +HH LFSN+  V G S+RF   L  R ++   +
Sbjct: 297 FSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLV 356

Query: 490 SDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPL 549
            D+ D++  HA   F  Y+ Y  N+ YQ+ T  +L+ +N  F   LR ++  P C  LP+
Sbjct: 357 EDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPM 416

Query: 550 PSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTE 609
            SFL+LP QR+TRL +L+  +  +T+  S R + A +AL A+SK++ +C+    RM++ E
Sbjct: 417 LSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERME 476

Query: 610 ELIRLTQRLRFHKVKALPLVSWSRRLEFQGEL---TELGCRRGGVLFASRPRFTPLCLLL 666
           ++  L  +L F KVK+LPL+S SR L  +GEL    E G  R     ASRP      L L
Sbjct: 477 QMYTLHTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFR---KIASRP---TCYLFL 530

Query: 667 FSDLLLITQPKSGQRLQVLDYAHRSLVQAQQV-----PDPSG-------PPTFRLSLLSN 714
           F+D+L++T+ KS +   V DYA  + +Q +++     P P G       P  F+++LL N
Sbjct: 531 FNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRN 590

Query: 715 HQGRPTHRLLQASSLSDMQRWLGA 738
            +GR    LL + S SD  RW+ A
Sbjct: 591 SEGRQEQLLLSSDSASDRARWIVA 614


>gi|194473700 Src homology 3 domain-containing guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 871

 Score =  242 bits (618), Expect = 9e-64
 Identities = 242/872 (27%), Positives = 375/872 (43%), Gaps = 94/872 (10%)

Query: 17  PRIIRPRPPSRSRAAQSPG-------PPHNGSS------PQELPRNSNDAPTPMCTPIFW 63
           P  +  R   R ++ QSP        P  +G +      P ++P  ++D+ T   +P+  
Sbjct: 26  PHQVLGRSKPRPQSYQSPNGLLITDFPVEDGGTLLAAQIPAQVP-TASDSRTVHRSPLLL 84

Query: 64  EPPAASLKPPALLPPSASRAS--LDSQTSPDSPSSTPTPSPVSRRSAS---PEPAPRSPV 118
                ++       P    AS  L    SP  P + P  SP S  + +   P P P   +
Sbjct: 85  GAQRRAVANGGTASPEYRAASPRLRRPKSPKLPKAVPGGSPKSPANGAVTLPAPPPPPVL 144

Query: 119 PPPKPSGSP--CTPLLPMAGVLAQN-GSASAPGTVRRLAGRFEGGAEGRAQDADAPEPGL 175
            PP+   +P  CTP   + G+ A    S +A G          G   GR   A  PE GL
Sbjct: 145 RPPRTPNAPAPCTPEEDLTGLTASPVPSPTANGLAANNDSPGSGSQSGRK--AKDPERGL 202

Query: 176 -QARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLELRWVPVGGYEEV 234
                  + E++ PL    SQEN   +         P V  +T     L+   VG  + +
Sbjct: 203 FPGPQKSSSEQKLPLQRLPSQENELLEN--------PSVVLSTNSPAALK---VGKQQII 251

Query: 235 PRVPRRASPLRTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFG 294
           P+    AS ++ S+S         P   L   RS  E    PL    + + V  D    G
Sbjct: 252 PK--SLASEIKISKSNNQNVE---PHKRLLKVRSMVEGLGGPLGHAGEESEVDNDVDSPG 306

Query: 295 DPPQPDLDLLSEDGIQTG---DSPDEAPQNT----PPATVEGREEEGL--------EVLK 339
              +          + +G   DSP  + +      P   V   ++E          ++LK
Sbjct: 307 SLRRGLRSTSYRRAVVSGFDFDSPTSSKKKNRMSQPVLKVVMEDKEKFSSLGRIKKKMLK 366

Query: 340 EQNWELPLQDEPLYQTYRAAVLSEELWGVGEDGSPSPANAGDAPTFPRPPGPRNTLWQEL 399
            Q      ++  LYQ Y+   L      +  D    P              P  + W +L
Sbjct: 367 GQGTFDGEENAVLYQNYKEKALD-----IDSDEESEPKEQKSDEKIVIHHKPLRSTWSQL 421

Query: 400 PAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHH 459
            AV+  GL  T+S +ER+ QE++FEV++SE SYL SL +L   F  S+ L DT+T  + H
Sbjct: 422 SAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERH 481

Query: 460 TLFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEE 519
            LFSN+  V   S++F   L +R +++  I D+ D+V  H    F  YV Y  N+ YQ+ 
Sbjct: 482 HLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQR 541

Query: 520 TYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSS 579
           T  +L+ TN  F   L R++S   C  LP+ SFL+LP QR+TRL +L+  I ++T + S 
Sbjct: 542 TLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSP 601

Query: 580 RQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQG 639
           + E  ++AL  VSK++  C+    +M++TE +  +  +L F K+K  PLVS SR L  +G
Sbjct: 602 KYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEF-KIKPFPLVSSSRWLVKRG 660

Query: 640 ELTELGCRRGGVLFASRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRS--LVQAQQ 697
           ELT        VLF+ R     +   LF+D+L+IT+ KS +   V DY+ R   LV++  
Sbjct: 661 ELT--AYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCD 718

Query: 698 VPDPSGPP-----------------TFRLSLLSNHQGRPTHRLLQASSLSDMQRWLGAFP 740
             + +  P                  F L++LSNH       LL A + S+  RW+ A  
Sbjct: 719 NEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALG 778

Query: 741 TPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSLESRAAPKHLHKTPEGWLK----- 795
                P +  T       +Q     S    + +  SL+         +  +GW +     
Sbjct: 779 HSSGKPPADRT-----SLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLR 833

Query: 796 -GLPGAFPAQLVCEVTGEHERRRHLRQNQRLL 826
            G  G FP +   E+T +    +++ +  RLL
Sbjct: 834 DGERGWFPMECAKEITCQATIDKNVERMGRLL 865


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 167/734 (22%), Positives = 282/734 (38%), Gaps = 123/734 (16%)

Query: 64  EPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSPVSRR-SASPEPAPRSP--VPP 120
           EP   +  PP   PP+ +          DS      P  ++RR S S    P  P  V P
Sbjct: 14  EPEHPATNPPGAAPPACA----------DSDPGASEPGLLARRGSGSALGGPLDPQFVGP 63

Query: 121 PKPS--GSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEGRAQDADAPEPGLQAR 178
              S   +P   +LP             P      A RF    EG       P PGL   
Sbjct: 64  SDTSLGAAPGHRVLPCG-----------PSPQHHRALRFSYHLEG-----SQPRPGLHQG 107

Query: 179 ADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRP-------GLELRWVPVGGY 231
             +  +  +   G   + +      L   P  P    + RP       G + +  P   Y
Sbjct: 108 NRILVKSLSLDPGQSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSY 167

Query: 232 EEVPRVPRRASPLRTSRSRPHP--PSI--GHPAVVLTSYRSTAERKLLPLLKPPKPTRVR 287
            ++PR+P    P+    SRP P  P +  G       S  S A   L+   +  +P  V 
Sbjct: 168 LQMPRMPPPLEPIPPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFER-EPVIVA 226

Query: 288 QDATIFGDPPQPDLDLLSEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLK---EQNWE 344
            D  + G  P P   ++          P    Q   P   EG     L +L        +
Sbjct: 227 SDRPVPGPSPGPPEPVML---------PQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEK 277

Query: 345 LPLQDEPLYQTYRAAVLSEELWGVGEDGSPSPANAGDAPTF---------PRPPGPRNT- 394
           +P +D  +  +  +   SEE   V +DG PS +     P           P  PG +   
Sbjct: 278 VPNRDSGI-DSISSPSNSEETCFVSDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVD 336

Query: 395 --------------LWQELPAVQASGLLDTLSPQERRMQESLF----EVVTSEASYLRSL 436
                           +E+P      L++     E  +Q+ +F    E++ +E +Y+  L
Sbjct: 337 SDLEEEDDEEEEEEKDREIPVP----LMERQESVELTVQQKVFHIANELLQTEKAYVSRL 392

Query: 437 RLLTDTF---VLSQALRDTLTPRDH-HTLFSNVQRVQGVSERFLATLLSRVRSS----PH 488
            LL   F   +L +A   +  P D  H +FSN+  +    ++FL   L +        P 
Sbjct: 393 HLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPR 452

Query: 489 ISDLCDVVHAHAVGPF-SVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERL 547
           I D+        + PF  +Y +YV+N     E  +   + + +F   +  +Q    C  L
Sbjct: 453 IGDILQ-----KLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNL 507

Query: 548 PLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQ 607
            L   +L P QRI R  +LL++ L +   GS   ++AQK+L  ++   E  +A + +M++
Sbjct: 508 TLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMER 567

Query: 608 TEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRFTPLCLLLF 667
             +L+++ + L   +     +VS ++ L  +G + +L  + G     ++ R+    L+LF
Sbjct: 568 MHKLLKVYELLGGEE----DIVSPTKELIKEGHILKLSAKNG----TTQDRY----LILF 615

Query: 668 SDLLLITQPK---SGQRLQVLDYAHRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPTHRLL 724
           +D LL   P+    GQ+  V        ++ ++  + + P TF +S      G+     L
Sbjct: 616 NDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVS------GKQRSLEL 669

Query: 725 QASSLSDMQRWLGA 738
           QA +  + + W+ A
Sbjct: 670 QARTEEEKKDWVQA 683



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 37/139 (26%), Positives = 48/139 (34%), Gaps = 21/139 (15%)

Query: 16  PPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTP-------IFWEPPAA 68
           P + + P P    R    PGPP    S +  P      P P   P           PP  
Sbjct: 119 PGQSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLE 178

Query: 69  SLKPPALLP-PSASRASLD-SQTSPDSPSSTPTPSPV------------SRRSASPEPAP 114
            + PP   P P+  R +   +  +  SPSS    S +             R    P P P
Sbjct: 179 PIPPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGP 238

Query: 115 RSPVPPPKPSGSPCTPLLP 133
             PV  P+P+  P  P LP
Sbjct: 239 PEPVMLPQPTSQPPVPQLP 257


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 74/275 (26%), Positives = 129/275 (46%), Gaps = 16/275 (5%)

Query: 407  LLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQ 466
            LLD L+P ER+ Q  + E++ +E +Y+  L+L+T+ F       + LT ++   +F N +
Sbjct: 1227 LLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWK 1286

Query: 467  RVQGVSERFLATLLSRVRSSPH---ISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSR 523
             +   + + L  L  R + S     +  + D++ A  +     Y+ +   Q        +
Sbjct: 1287 ELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQ-LPHMQPYIRFCSRQLNGAALIQQ 1345

Query: 524  LMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQEN 583
              D    F   ++RL   P+C+ +PL SF+L P QR+TR  ++++NIL  T E      +
Sbjct: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405

Query: 584  AQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTE 643
             + AL    K  E CS     +++ E   RL + ++ H    +     S +L F      
Sbjct: 1406 LKHAL---EKAEELCSQVNEGVREKENSDRL-EWIQAH----VQCEGLSEQLVFNSVTNC 1457

Query: 644  LGCRR---GGVLFASRPRFTPLCLLLFSDLLLITQ 675
            LG R+    G L+ ++     L   LF+D LL+TQ
Sbjct: 1458 LGPRKFLHSGKLYKAKSN-KELYGFLFNDFLLLTQ 1491



 Score = 30.4 bits (67), Expect = 7.2
 Identities = 30/130 (23%), Positives = 46/130 (35%), Gaps = 11/130 (8%)

Query: 1   MSAQSLPAATPPTQKPPRIIRPRPPSRSRAAQSPGPPHNGSSPQEL---------PRNSN 51
           +    LP+A PP  K   +     P+      +  PP    +P  +         P   +
Sbjct: 89  LQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVVGMSPTLVS 148

Query: 52  DAPTPMCTPIFWEPPAASLKPPALLPPSAS--RASLDSQTSPDSPSSTPTPSPVSRRSAS 109
             PT    P+    P      PA   P+A+  ++S  S++ P S  +T      S   AS
Sbjct: 149 SVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVAS 208

Query: 110 PEPAPRSPVP 119
             P     VP
Sbjct: 209 VPPVAEWAVP 218


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 79/335 (23%), Positives = 152/335 (45%), Gaps = 34/335 (10%)

Query: 415 ERRMQESLFEVVTSEASYLRSLRLLTDTF---VLSQALRDTLTPRDHHTLFSNVQRVQGV 471
           E+++ +   E++ +E +Y+  L LL   F   +L +A R +      + +FSN+  +   
Sbjct: 204 EQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAF 263

Query: 472 SERFLATLLSRV----RSSPHISDLCDVVHAHAVGPF-SVYVDYVRNQQYQEETYSRLMD 526
             +FL   L +      ++P I D+        + PF  +Y +YV+      E    + +
Sbjct: 264 HSKFLLPELEKRMQEWETTPRIGDILQ-----KLAPFLKMYGEYVKGFDNAMELVKNMTE 318

Query: 527 TNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQK 586
              +F + +  +Q    C  L L   +L P QRI R  MLL++ LR+    S    +A+K
Sbjct: 319 RIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKK 378

Query: 587 ALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGC 646
           +L  +S      ++ + +M+  ++L+ + + L   +     +V+ S  L  +G++ +L  
Sbjct: 379 SLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEE----DIVNPSNELIKEGQILKLAA 434

Query: 647 RRGGVLFASRPRFTPLCLLLFSDLLLITQPK---SGQRLQVLDYAHRSLVQAQQVPDPSG 703
           R      +++ R+    L LF+++LL   PK    G +  V        ++  +  +   
Sbjct: 435 RN----TSAQERY----LFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEY 486

Query: 704 PPTFRLSLLSNHQGRPTHRLLQASSLSDMQRWLGA 738
           P TF++S      G+     LQASS  D + W+ A
Sbjct: 487 PHTFQVS------GKERTLELQASSAQDKEEWIKA 515


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 91/342 (26%), Positives = 155/342 (45%), Gaps = 39/342 (11%)

Query: 410 TLSPQERRMQESLFEVVTSEASYLRSLRLLTDTF---VLSQALRDTLTPRDH-HTLFSNV 465
           T  P+++ +QE L     +E +Y+  L LL   F   +L  A      P D    +FSN+
Sbjct: 99  TQEPEKKIVQELL----ETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNI 154

Query: 466 QRV-QGVSERFLATLLSRV---RSSPHISDLCDVVHAHAVGPF-SVYVDYVRNQQYQEET 520
             + Q  S+ FL  L  R+    ++P I D+        + PF  +Y +YV+N +   E 
Sbjct: 155 SSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQ-----KLAPFLKMYSEYVKNFERAAEL 209

Query: 521 YSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSR 580
            +   D +  F   L R+QS      L L   +L P QRI R  +LL+  +++    +  
Sbjct: 210 LATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPD 269

Query: 581 QENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGE 640
           Q +AQKAL  +    +  +A +  M++ ++L  + QRL         +V  S  L  +G 
Sbjct: 270 QADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLED----DIVDPSNTLLREGP 325

Query: 641 LTELGCRRGGVLFASRPRFTPLCLLLFSDLLLITQPK---SGQRLQVLDYAHRSLVQAQQ 697
           + ++  RR   +     R+    L LF+++LL   P+    G + QV      + ++ ++
Sbjct: 326 VLKISFRRNDPM----ERY----LFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRE 377

Query: 698 VPDPSGPPTFRLSLLSNHQGRPTHRLLQASSLSDMQRWLGAF 739
           + D   P +F +S      G+     LQA S  +M  W+ AF
Sbjct: 378 LMDAEFPHSFLVS------GKQRTLELQARSQEEMISWMQAF 413


>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
            [Homo sapiens]
          Length = 1562

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 81/303 (26%), Positives = 134/303 (44%), Gaps = 16/303 (5%)

Query: 389  PGPRNTLWQELPAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQA 448
            P P    WQ         ++  L+ +E   QE + E+  +EAS+LR+LR+L D     + 
Sbjct: 749  PEPDAQNWQH---TVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVL-DLIFYQRM 804

Query: 449  LRDTLTPRDHHT-LFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVY 507
             ++ L PR+    LF N+  +  +   +   +       P I ++ D++ A   GP    
Sbjct: 805  KKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREE 864

Query: 508  VDYVRNQ--QYQE---ETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITR 562
            +  V  Q   YQ    E          RF   ++  +S P+C RL L   ++   QR+T+
Sbjct: 865  LQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTK 924

Query: 563  LRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHK 622
              +LL++I++ TE G+S  E   +A     +I++  +  V   KQTE   RL    +   
Sbjct: 925  YPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAV---KQTENRHRLEGYQKRLD 981

Query: 623  VKALPLVSWSRRLEFQG-ELTELGCRRGGVLF--ASRPRFTPLCLLLFSDLLLITQPKSG 679
              AL   S     EF+  +LT       G L    S+ +   L +LL  DLL++ Q +  
Sbjct: 982  ATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDE 1041

Query: 680  QRL 682
            + L
Sbjct: 1042 KLL 1044


>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
            [Homo sapiens]
          Length = 1522

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 81/303 (26%), Positives = 134/303 (44%), Gaps = 16/303 (5%)

Query: 389  PGPRNTLWQELPAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQA 448
            P P    WQ         ++  L+ +E   QE + E+  +EAS+LR+LR+L D     + 
Sbjct: 709  PEPDAQNWQH---TVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVL-DLIFYQRM 764

Query: 449  LRDTLTPRDHHT-LFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVY 507
             ++ L PR+    LF N+  +  +   +   +       P I ++ D++ A   GP    
Sbjct: 765  KKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREE 824

Query: 508  VDYVRNQ--QYQE---ETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITR 562
            +  V  Q   YQ    E          RF   ++  +S P+C RL L   ++   QR+T+
Sbjct: 825  LQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTK 884

Query: 563  LRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHK 622
              +LL++I++ TE G+S  E   +A     +I++  +  V   KQTE   RL    +   
Sbjct: 885  YPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAV---KQTENRHRLEGYQKRLD 941

Query: 623  VKALPLVSWSRRLEFQG-ELTELGCRRGGVLF--ASRPRFTPLCLLLFSDLLLITQPKSG 679
              AL   S     EF+  +LT       G L    S+ +   L +LL  DLL++ Q +  
Sbjct: 942  ATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDE 1001

Query: 680  QRL 682
            + L
Sbjct: 1002 KLL 1004


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 67/273 (24%), Positives = 125/273 (45%), Gaps = 16/273 (5%)

Query: 408  LDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQR 467
            LDT+ P ER+ Q  + E++ +E  Y+  L+L+ + F    A    LT  +   +F N + 
Sbjct: 1173 LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKE 1232

Query: 468  VQGVSERFLATLLSRVRSSPH---ISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRL 524
            +   + + L  L  R ++      +  + D++ A  +     Y+ +   Q        + 
Sbjct: 1233 LIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAE-LSHMQAYIRFCSCQLNGAALLQQK 1291

Query: 525  MDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENA 584
             D +  F   L++L S P+C+ +PL SFLL P QRITR  +L+++IL  T E  +   + 
Sbjct: 1292 TDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSL 1351

Query: 585  QKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTEL 644
            + AL    ++  + +  V   + ++ L  +   ++   +        + +L F      L
Sbjct: 1352 KLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL--------AEQLIFNSLTNCL 1403

Query: 645  GCRR---GGVLFASRPRFTPLCLLLFSDLLLIT 674
            G R+    G L+ ++     L   LF+D LL+T
Sbjct: 1404 GPRKLLHSGKLYKTKSN-KELHGFLFNDFLLLT 1435



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 32/112 (28%), Positives = 43/112 (38%), Gaps = 18/112 (16%)

Query: 1   MSAQSLPAATPPTQKPPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTP 60
           +  Q LP   PP  K P +  P   +R      P    N S PQ LP      P    T 
Sbjct: 90  LQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMP----NLSIPQPLP------PAAPITS 139

Query: 61  IFWEPPAASLKP---PALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRSAS 109
           +       +L P   P  L PS S +SL     P+  +S   P P+   S++
Sbjct: 140 LSSATSGTNLPPLMMPTPLVPSVSTSSL-----PNGTASLIQPLPIPYSSST 186


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 67/273 (24%), Positives = 125/273 (45%), Gaps = 16/273 (5%)

Query: 408  LDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQR 467
            LDT+ P ER+ Q  + E++ +E  Y+  L+L+ + F    A    LT  +   +F N + 
Sbjct: 1200 LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKE 1259

Query: 468  VQGVSERFLATLLSRVRSSPH---ISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRL 524
            +   + + L  L  R ++      +  + D++ A  +     Y+ +   Q        + 
Sbjct: 1260 LIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAE-LSHMQAYIRFCSCQLNGAALLQQK 1318

Query: 525  MDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENA 584
             D +  F   L++L S P+C+ +PL SFLL P QRITR  +L+++IL  T E  +   + 
Sbjct: 1319 TDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSL 1378

Query: 585  QKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTEL 644
            + AL    ++  + +  V   + ++ L  +   ++   +        + +L F      L
Sbjct: 1379 KLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL--------AEQLIFNSLTNCL 1430

Query: 645  GCRR---GGVLFASRPRFTPLCLLLFSDLLLIT 674
            G R+    G L+ ++     L   LF+D LL+T
Sbjct: 1431 GPRKLLHSGKLYKTKSN-KELHGFLFNDFLLLT 1462



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 32/112 (28%), Positives = 43/112 (38%), Gaps = 18/112 (16%)

Query: 1   MSAQSLPAATPPTQKPPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTP 60
           +  Q LP   PP  K P +  P   +R      P    N S PQ LP      P    T 
Sbjct: 90  LQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMP----NLSIPQPLP------PAAPITS 139

Query: 61  IFWEPPAASLKP---PALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRSAS 109
           +       +L P   P  L PS S +SL     P+  +S   P P+   S++
Sbjct: 140 LSSATSGTNLPPLMMPTPLVPSVSTSSL-----PNGTASLIQPLPIPYSSST 186


>gi|38373682 pleckstrin homology domain containing family G member 5
           isoform a [Homo sapiens]
          Length = 1006

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 56/224 (25%), Positives = 113/224 (50%), Gaps = 10/224 (4%)

Query: 409 DTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFV---LSQALRDTLTPRDHHTLFSNV 465
           + L+ ++   QE+++E++ +EASY+R LR++ + F+   L+      L   +   LFSN+
Sbjct: 328 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 387

Query: 466 QRVQGVSERF----LATLLSRVRSSPHISDLCDVVHAHAV--GPFSVYVDYVRNQQYQEE 519
             +  +  R     +A +L + R +  +    D +    +    F  Y+ Y   ++   E
Sbjct: 388 PEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCME 447

Query: 520 TYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSS 579
               L+  N  F A +   +  P+C+RL L   L  P QR+T+  +LL+++LR+TEE  +
Sbjct: 448 YMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRA 507

Query: 580 RQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKV 623
           + E     +G+V + I   +A + + ++ + L  +  R+  ++V
Sbjct: 508 K-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEV 550



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 55/214 (25%), Positives = 76/214 (35%), Gaps = 25/214 (11%)

Query: 47  PRNSNDAPTPMCTPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTP---TPSPV 103
           P +S    T + T      P + L P  L P      S+DS     SP+S      P P+
Sbjct: 779 PFSSQSDETSLSTTASSATPTSELLP--LGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPM 836

Query: 104 SRRSASPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEG 163
           +        +PR P PPP P     TP+  ++       S S    ++ LAG    G  G
Sbjct: 837 AELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAG---AGTHG 893

Query: 164 RAQDADAPEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLE- 222
                 AP   L        E    +   G +  G+P        C       + PGL  
Sbjct: 894 ---TPSAPSRSL-------SELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVG 943

Query: 223 -LRWVPVGGY-EEVPRVPRRASPLRTSRSRPHPP 254
            L   P G + +    +P  ASP    R +P PP
Sbjct: 944 CLAGEPAGSHRKRCGDLPSGASP----RVQPEPP 973


>gi|111154084 pleckstrin homology domain containing family G member
           5 isoform b [Homo sapiens]
          Length = 1083

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 56/224 (25%), Positives = 113/224 (50%), Gaps = 10/224 (4%)

Query: 409 DTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFV---LSQALRDTLTPRDHHTLFSNV 465
           + L+ ++   QE+++E++ +EASY+R LR++ + F+   L+      L   +   LFSN+
Sbjct: 405 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 464

Query: 466 QRVQGVSERF----LATLLSRVRSSPHISDLCDVVHAHAV--GPFSVYVDYVRNQQYQEE 519
             +  +  R     +A +L + R +  +    D +    +    F  Y+ Y   ++   E
Sbjct: 465 PEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCME 524

Query: 520 TYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSS 579
               L+  N  F A +   +  P+C+RL L   L  P QR+T+  +LL+++LR+TEE  +
Sbjct: 525 YMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRA 584

Query: 580 RQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKV 623
           + E     +G+V + I   +A + + ++ + L  +  R+  ++V
Sbjct: 585 K-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEV 627



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 55/214 (25%), Positives = 76/214 (35%), Gaps = 25/214 (11%)

Query: 47   PRNSNDAPTPMCTPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTP---TPSPV 103
            P +S    T + T      P + L P  L P      S+DS     SP+S      P P+
Sbjct: 856  PFSSQSDETSLSTTASSATPTSELLP--LGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPM 913

Query: 104  SRRSASPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEG 163
            +        +PR P PPP P     TP+  ++       S S    ++ LAG    G  G
Sbjct: 914  AELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAG---AGTHG 970

Query: 164  RAQDADAPEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLE- 222
                  AP   L        E    +   G +  G+P        C       + PGL  
Sbjct: 971  ---TPSAPSRSL-------SELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVG 1020

Query: 223  -LRWVPVGGY-EEVPRVPRRASPLRTSRSRPHPP 254
             L   P G + +    +P  ASP    R +P PP
Sbjct: 1021 CLAGEPAGSHRKRCGDLPSGASP----RVQPEPP 1050


>gi|111154088 pleckstrin homology domain containing family G member
           5 isoform a [Homo sapiens]
          Length = 1006

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 56/224 (25%), Positives = 113/224 (50%), Gaps = 10/224 (4%)

Query: 409 DTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFV---LSQALRDTLTPRDHHTLFSNV 465
           + L+ ++   QE+++E++ +EASY+R LR++ + F+   L+      L   +   LFSN+
Sbjct: 328 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 387

Query: 466 QRVQGVSERF----LATLLSRVRSSPHISDLCDVVHAHAV--GPFSVYVDYVRNQQYQEE 519
             +  +  R     +A +L + R +  +    D +    +    F  Y+ Y   ++   E
Sbjct: 388 PEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCME 447

Query: 520 TYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSS 579
               L+  N  F A +   +  P+C+RL L   L  P QR+T+  +LL+++LR+TEE  +
Sbjct: 448 YMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRA 507

Query: 580 RQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKV 623
           + E     +G+V + I   +A + + ++ + L  +  R+  ++V
Sbjct: 508 K-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEV 550



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 55/214 (25%), Positives = 76/214 (35%), Gaps = 25/214 (11%)

Query: 47  PRNSNDAPTPMCTPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTP---TPSPV 103
           P +S    T + T      P + L P  L P      S+DS     SP+S      P P+
Sbjct: 779 PFSSQSDETSLSTTASSATPTSELLP--LGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPM 836

Query: 104 SRRSASPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEG 163
           +        +PR P PPP P     TP+  ++       S S    ++ LAG    G  G
Sbjct: 837 AELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAG---AGTHG 893

Query: 164 RAQDADAPEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLE- 222
                 AP   L        E    +   G +  G+P        C       + PGL  
Sbjct: 894 ---TPSAPSRSL-------SELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVG 943

Query: 223 -LRWVPVGGY-EEVPRVPRRASPLRTSRSRPHPP 254
            L   P G + +    +P  ASP    R +P PP
Sbjct: 944 CLAGEPAGSHRKRCGDLPSGASP----RVQPEPP 973


>gi|111154080 pleckstrin homology domain containing family G member
           5 isoform a [Homo sapiens]
          Length = 1006

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 56/224 (25%), Positives = 113/224 (50%), Gaps = 10/224 (4%)

Query: 409 DTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFV---LSQALRDTLTPRDHHTLFSNV 465
           + L+ ++   QE+++E++ +EASY+R LR++ + F+   L+      L   +   LFSN+
Sbjct: 328 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 387

Query: 466 QRVQGVSERF----LATLLSRVRSSPHISDLCDVVHAHAV--GPFSVYVDYVRNQQYQEE 519
             +  +  R     +A +L + R +  +    D +    +    F  Y+ Y   ++   E
Sbjct: 388 PEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCME 447

Query: 520 TYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSS 579
               L+  N  F A +   +  P+C+RL L   L  P QR+T+  +LL+++LR+TEE  +
Sbjct: 448 YMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRA 507

Query: 580 RQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKV 623
           + E     +G+V + I   +A + + ++ + L  +  R+  ++V
Sbjct: 508 K-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEV 550



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 55/214 (25%), Positives = 76/214 (35%), Gaps = 25/214 (11%)

Query: 47  PRNSNDAPTPMCTPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTP---TPSPV 103
           P +S    T + T      P + L P  L P      S+DS     SP+S      P P+
Sbjct: 779 PFSSQSDETSLSTTASSATPTSELLP--LGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPM 836

Query: 104 SRRSASPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEG 163
           +        +PR P PPP P     TP+  ++       S S    ++ LAG    G  G
Sbjct: 837 AELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAG---AGTHG 893

Query: 164 RAQDADAPEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLE- 222
                 AP   L        E    +   G +  G+P        C       + PGL  
Sbjct: 894 ---TPSAPSRSL-------SELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVG 943

Query: 223 -LRWVPVGGY-EEVPRVPRRASPLRTSRSRPHPP 254
            L   P G + +    +P  ASP    R +P PP
Sbjct: 944 CLAGEPAGSHRKRCGDLPSGASP----RVQPEPP 973


>gi|111154078 pleckstrin homology domain containing family G member
           5 isoform c [Homo sapiens]
          Length = 1062

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 56/224 (25%), Positives = 113/224 (50%), Gaps = 10/224 (4%)

Query: 409 DTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFV---LSQALRDTLTPRDHHTLFSNV 465
           + L+ ++   QE+++E++ +EASY+R LR++ + F+   L+      L   +   LFSN+
Sbjct: 384 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 443

Query: 466 QRVQGVSERF----LATLLSRVRSSPHISDLCDVVHAHAV--GPFSVYVDYVRNQQYQEE 519
             +  +  R     +A +L + R +  +    D +    +    F  Y+ Y   ++   E
Sbjct: 444 PEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCME 503

Query: 520 TYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSS 579
               L+  N  F A +   +  P+C+RL L   L  P QR+T+  +LL+++LR+TEE  +
Sbjct: 504 YMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRA 563

Query: 580 RQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKV 623
           + E     +G+V + I   +A + + ++ + L  +  R+  ++V
Sbjct: 564 K-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEV 606



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 55/214 (25%), Positives = 76/214 (35%), Gaps = 25/214 (11%)

Query: 47   PRNSNDAPTPMCTPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTP---TPSPV 103
            P +S    T + T      P + L P  L P      S+DS     SP+S      P P+
Sbjct: 835  PFSSQSDETSLSTTASSATPTSELLP--LGPVDGRSCSMDSAYGTLSPTSLQDFVAPGPM 892

Query: 104  SRRSASPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEG 163
            +        +PR P PPP P     TP+  ++       S S    ++ LAG    G  G
Sbjct: 893  AELVPRAPESPRVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEASLLQLLAG---AGTHG 949

Query: 164  RAQDADAPEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLE- 222
                  AP   L        E    +   G +  G+P        C       + PGL  
Sbjct: 950  ---TPSAPSRSL-------SELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVG 999

Query: 223  -LRWVPVGGY-EEVPRVPRRASPLRTSRSRPHPP 254
             L   P G + +    +P  ASP    R +P PP
Sbjct: 1000 CLAGEPAGSHRKRCGDLPSGASP----RVQPEPP 1029


>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
           [Homo sapiens]
          Length = 927

 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 105/437 (24%), Positives = 182/437 (41%), Gaps = 60/437 (13%)

Query: 299 PDLDLLSEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLKEQNWELPLQDEPLYQTYRA 358
           PD +  ++  ++ GDS  + P +          +EG E       E P   EP       
Sbjct: 349 PDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAET------ESP---EP------- 392

Query: 359 AVLSEELWGVGEDGSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERRM 418
                     G++G P  +     P    PPG     W+EL        L +L   + + 
Sbjct: 393 ----------GDEGEPGRSGLELEPE--EPPG-----WRELVPPDT---LHSLPKSQVKR 432

Query: 419 QESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLAT 478
           QE + E++ +EA+++R LR+L D F    A        +   +F ++  +  V   FL  
Sbjct: 433 QEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDR 492

Query: 479 LLSRVRSSPH-ISDLCDVVHAHAVGPFSVYVDYVRN-----QQYQEETYSRLMDTNVRFS 532
           L+ R + S + I ++ DV+ A   G    +   + +     Q +  E        + RF 
Sbjct: 493 LMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFC 552

Query: 533 AELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVS 592
           A ++  +S P+C RL L   +    QR+T+  +LLQ+I + TEE + R E  + A     
Sbjct: 553 AFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTER-EKVELAAECCR 611

Query: 593 KIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQG-ELTELGCRRGGV 651
           +I+   +  V   +  E+L+RL    R   +  L   S     EF+  ++T+      G 
Sbjct: 612 EILHHVNQAV---RDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGP 668

Query: 652 LF--ASRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGP----P 705
           L    ++ +   + +LL  DLLL+ Q +  +RL +  ++ R+L      P P G     P
Sbjct: 669 LTWRVTKDKAVEVHVLLLDDLLLLLQ-RQDERLLLKSHS-RTL-----TPTPDGKTMLRP 721

Query: 706 TFRLSLLSNHQGRPTHR 722
             RL+     +    H+
Sbjct: 722 VLRLTSAMTREVATDHK 738


>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
           [Homo sapiens]
          Length = 879

 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 105/437 (24%), Positives = 182/437 (41%), Gaps = 60/437 (13%)

Query: 299 PDLDLLSEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLKEQNWELPLQDEPLYQTYRA 358
           PD +  ++  ++ GDS  + P +          +EG E       E P   EP       
Sbjct: 301 PDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAET------ESP---EP------- 344

Query: 359 AVLSEELWGVGEDGSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERRM 418
                     G++G P  +     P    PPG     W+EL        L +L   + + 
Sbjct: 345 ----------GDEGEPGRSGLELEPE--EPPG-----WRELVPPDT---LHSLPKSQVKR 384

Query: 419 QESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLAT 478
           QE + E++ +EA+++R LR+L D F    A        +   +F ++  +  V   FL  
Sbjct: 385 QEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDR 444

Query: 479 LLSRVRSSPH-ISDLCDVVHAHAVGPFSVYVDYVRN-----QQYQEETYSRLMDTNVRFS 532
           L+ R + S + I ++ DV+ A   G    +   + +     Q +  E        + RF 
Sbjct: 445 LMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFC 504

Query: 533 AELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVS 592
           A ++  +S P+C RL L   +    QR+T+  +LLQ+I + TEE + R E  + A     
Sbjct: 505 AFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTER-EKVELAAECCR 563

Query: 593 KIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQG-ELTELGCRRGGV 651
           +I+   +  V   +  E+L+RL    R   +  L   S     EF+  ++T+      G 
Sbjct: 564 EILHHVNQAV---RDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGP 620

Query: 652 LF--ASRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGP----P 705
           L    ++ +   + +LL  DLLL+ Q +  +RL +  ++ R+L      P P G     P
Sbjct: 621 LTWRVTKDKAVEVHVLLLDDLLLLLQ-RQDERLLLKSHS-RTL-----TPTPDGKTMLRP 673

Query: 706 TFRLSLLSNHQGRPTHR 722
             RL+     +    H+
Sbjct: 674 VLRLTSAMTREVATDHK 690


>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
           [Homo sapiens]
          Length = 912

 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 105/437 (24%), Positives = 182/437 (41%), Gaps = 60/437 (13%)

Query: 299 PDLDLLSEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLKEQNWELPLQDEPLYQTYRA 358
           PD +  ++  ++ GDS  + P +          +EG E       E P   EP       
Sbjct: 334 PDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAET------ESP---EP------- 377

Query: 359 AVLSEELWGVGEDGSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERRM 418
                     G++G P  +     P    PPG     W+EL        L +L   + + 
Sbjct: 378 ----------GDEGEPGRSGLELEPE--EPPG-----WRELVPPDT---LHSLPKSQVKR 417

Query: 419 QESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLAT 478
           QE + E++ +EA+++R LR+L D F    A        +   +F ++  +  V   FL  
Sbjct: 418 QEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDR 477

Query: 479 LLSRVRSSPH-ISDLCDVVHAHAVGPFSVYVDYVRN-----QQYQEETYSRLMDTNVRFS 532
           L+ R + S + I ++ DV+ A   G    +   + +     Q +  E        + RF 
Sbjct: 478 LMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFC 537

Query: 533 AELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVS 592
           A ++  +S P+C RL L   +    QR+T+  +LLQ+I + TEE + R E  + A     
Sbjct: 538 AFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTER-EKVELAAECCR 596

Query: 593 KIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQG-ELTELGCRRGGV 651
           +I+   +  V   +  E+L+RL    R   +  L   S     EF+  ++T+      G 
Sbjct: 597 EILHHVNQAV---RDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGP 653

Query: 652 LF--ASRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGP----P 705
           L    ++ +   + +LL  DLLL+ Q +  +RL +  ++ R+L      P P G     P
Sbjct: 654 LTWRVTKDKAVEVHVLLLDDLLLLLQ-RQDERLLLKSHS-RTL-----TPTPDGKTMLRP 706

Query: 706 TFRLSLLSNHQGRPTHR 722
             RL+     +    H+
Sbjct: 707 VLRLTSAMTREVATDHK 723


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 75/243 (30%), Positives = 94/243 (38%), Gaps = 52/243 (21%)

Query: 7   PAATPPTQKPPRI------IRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTP 60
           P+ATPP+Q PP +      + P PP+    + S  PP     P   P      P P   P
Sbjct: 462 PSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPP 521

Query: 61  IFWEPPAASL-KPPALLPPSASRASLDSQTSPDSPSSTPTPS----------------PV 103
               PP  +L  PPA  P  A  +   S + P SP +TP P                 P 
Sbjct: 522 ALATPPLQALPSPPASFPGQAPFS--PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPA 579

Query: 104 S------RRSASPEP-----APR-----SPVPPPKPSGSPCTPLLPMAGVLAQNGSASAP 147
           S      RR  +P P      PR     +P PPP PS SP + L   +G      S+SA 
Sbjct: 580 SPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTL---SGPDLAGHSSSAT 636

Query: 148 GTVRRLAGRFEGGAEGRAQDADAPEPGLQARADVNGER--EAPLTGSGSQENGAPDAGLA 205
            T   L G ++ G EG A  +  P+  L A       R    PL        GAP A L 
Sbjct: 637 STPEELRG-YDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLA-----FRGAPGAPLP 690

Query: 206 CPP 208
            PP
Sbjct: 691 WPP 693



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 87/352 (24%), Positives = 126/352 (35%), Gaps = 63/352 (17%)

Query: 7   PAATPPTQKPPRIIRP------RPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTP 60
           P  TPP +     + P        PS S A QS  PP   ++P     +S+     + TP
Sbjct: 283 PQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATP-----HSSSLTCQLATP 337

Query: 61  IFWEPPAASLKP-------PALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRSASPEPA 113
           +   PP+ S  P       P   PPS +  SL S T   + S  P+P      +  P+  
Sbjct: 338 LPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAP 397

Query: 114 PRSPVP----PPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEGRAQDAD 169
           P   +P    PP P  SP  PL P+A    Q  +A A   V  L   F            
Sbjct: 398 PALALPPLQAPPSPPASP--PLSPLATPSPQAPNALA---VHLLQAPF------------ 440

Query: 170 APEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLELRWVPVG 229
           +P P    +A  +     P++ S +  + AP + LA PP          P +     P  
Sbjct: 441 SPPPSPPVQAPFSPPASPPVSPSATPPSQAPPS-LAAPPLQVPPSPPASPPMSPSATPP- 498

Query: 230 GYEEVPRVPRRASPLRTSRSRPH-PPSIGHPAVVL-----------TSYRSTAERKLLPL 277
              + P  P  A PL+ ++  P  PP++  P +               +  +A   + PL
Sbjct: 499 --PQAP-PPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL 555

Query: 278 LKPPKPTRVRQDATIFGDPPQPDLDLLSEDGIQTGDSPDEAPQNTPPATVEG 329
             PP        A +   PP P           T  +P   P   P  +V G
Sbjct: 556 ATPPPQAPPVLAAPLLQVPPSPPAS-------PTLQAPRRPPTPGPDTSVSG 600



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 95/356 (26%), Positives = 129/356 (36%), Gaps = 73/356 (20%)

Query: 3   AQSLPAATPPTQKPPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTPIF 62
           A++  AA  P  + P ++ PRPP   R    P PP                 TP    + 
Sbjct: 8   AKAGAAARTPAARAPGLLTPRPPGSPR----PPPP----------------VTPAALRVL 47

Query: 63  WEPPAASLKP---------PALLPPSASRA--SLDSQTSPDSPSSTPTPSPVSRRSASPE 111
               A   KP          A +P SA RA  +  + TS  +P+S P  S    R+   +
Sbjct: 48  GAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAK 107

Query: 112 PAPRSPVPPPKPSGSPCTPLLPMAGVLAQNG-SASAPGTVRR----LAGRFEGGAEGRAQ 166
                PV  P  +     P     G L Q G   SA  TV R     A +    + G  +
Sbjct: 108 NTSPGPVSSPGRASGTTRP-----GPLGQKGLRISAEETVARGKATEAPKRSALSAGARR 162

Query: 167 DADAPEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCP-----------CVCH 215
           D   P PG  + A     R A        E G P    +  P  P               
Sbjct: 163 DTSGPTPGTPSPAMARRSRAA------GTEVGLPRPAPSARPRPPTEGPRKSVSSASEHS 216

Query: 216 TTRPGLELRWVP-VGGYEEVP---RVPRRASPLRTSRSRPHPPSIGHPAVVLTSYRSTAE 271
           TT P    R  P  GG  + P    +   A+PL +S +R  P + G P     ++ S  +
Sbjct: 217 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPL-SSPARSGPSARGTPRA--PAHPSQPK 273

Query: 272 RKLLPLLKPPKPTRVRQDATIFGDPPQPDLDLLSEDGIQTGDSPDEAPQNTPPATV 327
            K L  L+PP+ T  R+DA        P L  LS   + T  SP  A Q+  P T+
Sbjct: 274 PKGLQALRPPQVTPPRKDAA-------PALGPLSSSPLAT-PSPSAALQSQAPPTL 321



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 96/420 (22%), Positives = 135/420 (32%), Gaps = 64/420 (15%)

Query: 4   QSLPAATPPTQKPPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTPIFW 63
           +S+ +A+  +   P     R PS     Q P      SS   L   +   P+   TP   
Sbjct: 207 KSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTP--- 263

Query: 64  EPPAASLKPP-----ALLPPSASRASLDSQTSPDSPSSTPTPSP---VSRRSASPEPAPR 115
             PA   +P      AL PP  +    D+  +    SS+P  +P    + +S +P   P 
Sbjct: 264 RAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPA 323

Query: 116 S--------------PVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGA 161
           +              P+ PP PS  P    LP           S P T    A    G  
Sbjct: 324 TPHSSSLTCQLATPLPLAPPSPSAPPSLQTLP-----------SPPATPPSQATTSLGSP 372

Query: 162 EGRAQDADAPEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGL 221
             +A  +  P P L   A    +    L     Q   AP +  A PP  P    + +   
Sbjct: 373 TLQATHSFLPSPPLSPLATPPPQAPPALALPPLQ---APPSPPASPPLSPLATPSPQAPN 429

Query: 222 ELRWVPVGGYEEVPRVPRRASPLRTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPP 281
            L    +      P  P   +P     S P  PS   P+    S  +       PL  PP
Sbjct: 430 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP------PLQVPP 483

Query: 282 KPTRVRQDATIFGDPPQPDLDLLSEDGIQTGDSPDEAPQ----------NTPPATVEGRE 331
            P      +     PPQ    L +   +Q    P +AP            +PPA+  G  
Sbjct: 484 SPPASPPMSPSATPPPQAPPPLAAPP-LQLAKPPPQAPPALATPPLQALPSPPASFPG-- 540

Query: 332 EEGLEVLKEQNWELPLQDEPLYQTYRAAVLSEELWGVGEDGSPSPANAGDAPTFPRPPGP 391
               +     +  LP+            VL+  L  V    SP  +    AP  P  PGP
Sbjct: 541 ----QAPFSPSASLPMSPLATPPPQAPPVLAAPLLQV--PPSPPASPTLQAPRRPPTPGP 594



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 45/162 (27%), Positives = 63/162 (38%), Gaps = 37/162 (22%)

Query: 3   AQSLPAATPPTQKPPRI-IRPRPPSR--SRAAQSPGPPHNGSSPQELPRNSNDAPTPMCT 59
           A  LP A P    PP +   P PP+   S+A  S G P   ++   LP   +   +P+ T
Sbjct: 335 ATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLP---SPPLSPLAT 391

Query: 60  PIFWEPPAASLKP------PALLPPSASRASLDSQT----------------------SP 91
           P    PPA +L P      P   PP +  A+   Q                       +P
Sbjct: 392 PPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAP 451

Query: 92  DSPSSTPTPSPVSRRSASPEP---APRSPVPPPKPSGSPCTP 130
            SP ++P  SP +   +   P   AP   VPP  P+  P +P
Sbjct: 452 FSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSP 493



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 39/127 (30%), Positives = 50/127 (39%), Gaps = 29/127 (22%)

Query: 22  PRPPSRSRAAQSPGPPHNG------SSPQEL------PRNSNDAPTPMCTPIFWEPPAAS 69
           P PPSRS ++   GP   G      S+P+EL      P     A  P    +    PAA 
Sbjct: 612 PPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAW 671

Query: 70  LKPPALLPPSASRASLDSQTSPDSPSSTP-----------TPSPVSRRSASPEPAPRSPV 118
            + PA  PP A R +  +   P  P++ P           T  P    SA+P P    P 
Sbjct: 672 SRGPA--PPLAFRGAPGAPL-PWPPATGPGSADGLCTIYETEGP---ESATPAPGALDPG 725

Query: 119 PPPKPSG 125
           P P  SG
Sbjct: 726 PSPGTSG 732


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 75/243 (30%), Positives = 94/243 (38%), Gaps = 52/243 (21%)

Query: 7   PAATPPTQKPPRI------IRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTP 60
           P+ATPP+Q PP +      + P PP+    + S  PP     P   P      P P   P
Sbjct: 423 PSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPP 482

Query: 61  IFWEPPAASL-KPPALLPPSASRASLDSQTSPDSPSSTPTPS----------------PV 103
               PP  +L  PPA  P  A  +   S + P SP +TP P                 P 
Sbjct: 483 ALATPPLQALPSPPASFPGQAPFS--PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPA 540

Query: 104 S------RRSASPEP-----APR-----SPVPPPKPSGSPCTPLLPMAGVLAQNGSASAP 147
           S      RR  +P P      PR     +P PPP PS SP + L   +G      S+SA 
Sbjct: 541 SPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTL---SGPDLAGHSSSAT 597

Query: 148 GTVRRLAGRFEGGAEGRAQDADAPEPGLQARADVNGER--EAPLTGSGSQENGAPDAGLA 205
            T   L G ++ G EG A  +  P+  L A       R    PL        GAP A L 
Sbjct: 598 STPEELRG-YDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLA-----FRGAPGAPLP 651

Query: 206 CPP 208
            PP
Sbjct: 652 WPP 654



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 85/358 (23%), Positives = 128/358 (35%), Gaps = 58/358 (16%)

Query: 1   MSAQSLPAATPPTQKPPRIIRPRPPSRSRAAQSPG----------PPHNGSSPQELPRNS 50
           +S+ + P ++P    P     PR P+     +  G          PP   ++P   P +S
Sbjct: 233 LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 292

Query: 51  ND--APTPMCTPIFWEPPAASLKP-PALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRS 107
           +    P+P   P    PP+    P P   PPS +  SL S T   + S  P+P      +
Sbjct: 293 SPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT 352

Query: 108 ASPEPAPRSPVP----PPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEG 163
             P+  P   +P    PP P  SP  PL P+A    Q  +A A   V  L   F      
Sbjct: 353 PPPQAPPALALPPLQAPPSPPASP--PLSPLATPSPQAPNALA---VHLLQAPF------ 401

Query: 164 RAQDADAPEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLEL 223
                 +P P    +A  +     P++ S +  + AP + LA PP          P +  
Sbjct: 402 ------SPPPSPPVQAPFSPPASPPVSPSATPPSQAPPS-LAAPPLQVPPSPPASPPMSP 454

Query: 224 RWVPVGGYEEVPRVPRRASPLRTSRSRPH-PPSIGHPAVVL-----------TSYRSTAE 271
              P     + P  P  A PL+ ++  P  PP++  P +               +  +A 
Sbjct: 455 SATPP---PQAP-PPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSAS 510

Query: 272 RKLLPLLKPPKPTRVRQDATIFGDPPQPDLDLLSEDGIQTGDSPDEAPQNTPPATVEG 329
             + PL  PP        A +   PP P           T  +P   P   P  +V G
Sbjct: 511 LPMSPLATPPPQAPPVLAAPLLQVPPSPPAS-------PTLQAPRRPPTPGPDTSVSG 561



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 88/346 (25%), Positives = 121/346 (34%), Gaps = 60/346 (17%)

Query: 3   AQSLPAATPPTQKPPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTPIF 62
           A++  AA  P  + P ++ PRPP   R    P PP                 TP    + 
Sbjct: 8   AKAGAAARTPAARAPGLLTPRPPGSPR----PPPP----------------VTPAALRVL 47

Query: 63  WEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRSASPEPAPRSPVPPPK 122
               A   KP A        A++        P+ T  P    R   +P     SP P   
Sbjct: 48  GAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSS 107

Query: 123 PSGSPCTPLLPMAGVLAQNG-SASAPGTVRR----LAGRFEGGAEGRAQDADAPEPGLQA 177
           P  +  T      G L Q G   SA  TV R     A +    + G  +D   P PG  +
Sbjct: 108 PGRASGT---TRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS 164

Query: 178 RADVNGEREAPLTGSGSQENGAPDAGLACPPCCP-----------CVCHTTRPGLELRWV 226
            A     R A        E G P    +  P  P               TT P    R  
Sbjct: 165 PAMARRSRAA------GTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRR 218

Query: 227 P-VGGYEEVP---RVPRRASPLRTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPK 282
           P  GG  + P    +   A+PL +S +R  P + G P     ++ S  + K L  L+PP+
Sbjct: 219 PSAGGGLQRPASRSLSSSATPL-SSPARSGPSARGTPRA--PAHPSQPKPKGLQALRPPQ 275

Query: 283 PTRVRQDATIFGDPPQPDLDLLSEDGIQTGDSPDEAPQNTPPATVE 328
            T  R+DA        P L  LS   + T  SP   P  + P +++
Sbjct: 276 VTPPRKDAA-------PALGPLSSSPLAT-PSPSAPPSPSAPPSLQ 313



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 95/404 (23%), Positives = 132/404 (32%), Gaps = 62/404 (15%)

Query: 11  PPTQKPPRII---------RPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTPI 61
           PPT+ P + +          P P +R R      P   G   +   R+ + + TP+ +P 
Sbjct: 191 PPTEGPRKSVSSASEHSTTEPSPAARRR------PSAGGGLQRPASRSLSSSATPLSSPA 244

Query: 62  FWEPPAASLKP----PALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRSASPEPAPRSP 117
              P A         P+   P   +A    Q +P    + P   P+S   +SP   P SP
Sbjct: 245 RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS---SSPLATP-SP 300

Query: 118 VPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEGRAQDADAPEPGLQA 177
             PP PS  P    LP           S P T    A    G    +A  +  P P L  
Sbjct: 301 SAPPSPSAPPSLQTLP-----------SPPATPPSQATTSLGSPTLQATHSFLPSPPLSP 349

Query: 178 RADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLELRWVPVGGYEEVPRV 237
            A    +    L     Q   AP +  A PP  P    + +    L    +      P  
Sbjct: 350 LATPPPQAPPALALPPLQ---APPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPS 406

Query: 238 PRRASPLRTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFGDPP 297
           P   +P     S P  PS   P+    S  +       PL  PP P      +     PP
Sbjct: 407 PPVQAPFSPPASPPVSPSATPPSQAPPSLAAP------PLQVPPSPPASPPMSPSATPPP 460

Query: 298 QPDLDLLSEDGIQTGDSPDEAPQ----------NTPPATVEGREEEGLEVLKEQNWELPL 347
           Q    L +   +Q    P +AP            +PPA+  G      +     +  LP+
Sbjct: 461 QAPPPLAAPP-LQLAKPPPQAPPALATPPLQALPSPPASFPG------QAPFSPSASLPM 513

Query: 348 QDEPLYQTYRAAVLSEELWGVGEDGSPSPANAGDAPTFPRPPGP 391
                       VL+  L  V    SP  +    AP  P  PGP
Sbjct: 514 SPLATPPPQAPPVLAAPLLQV--PPSPPASPTLQAPRRPPTPGP 555



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 39/127 (30%), Positives = 50/127 (39%), Gaps = 29/127 (22%)

Query: 22  PRPPSRSRAAQSPGPPHNG------SSPQEL------PRNSNDAPTPMCTPIFWEPPAAS 69
           P PPSRS ++   GP   G      S+P+EL      P     A  P    +    PAA 
Sbjct: 573 PPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAW 632

Query: 70  LKPPALLPPSASRASLDSQTSPDSPSSTP-----------TPSPVSRRSASPEPAPRSPV 118
            + PA  PP A R +  +   P  P++ P           T  P    SA+P P    P 
Sbjct: 633 SRGPA--PPLAFRGAPGAPL-PWPPATGPGSADGLCTIYETEGP---ESATPAPGALDPG 686

Query: 119 PPPKPSG 125
           P P  SG
Sbjct: 687 PSPGTSG 693


>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
            sapiens]
          Length = 1544

 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 95/391 (24%), Positives = 164/391 (41%), Gaps = 36/391 (9%)

Query: 364  ELWGVGEDGSPSPANAGDAPTFPRPPGP----RNTL------WQELPAVQASGLLDTLSP 413
            E+  V E G+P P    D+  F           N L      WQ+L + +   +L  L P
Sbjct: 727  EVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSRE---VLLGLKP 783

Query: 414  QERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQ---- 469
             E + QE + E+  +E +++R+L++L   F    +    L+P +   +FSN++ +     
Sbjct: 784  CEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHI 843

Query: 470  GVSERFLATLLSRVRSSPHISD-LCDVVHAHAVGPFS-----VYVDYVRNQQYQEETYSR 523
            G++E+  A    R R+   + D + + +     GP           +  NQ +  E    
Sbjct: 844  GLNEQMKAV---RKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKS 900

Query: 524  LMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQEN 583
                + RF   ++  +S P C RL L   +    QR+T+  +LL NI + TE  + R E 
Sbjct: 901  RQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTER-EK 959

Query: 584  AQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQG-ELT 642
             +KA     +I+   +  V   K+ E   RL    R     +L L  +    E +  +LT
Sbjct: 960  VKKAADHCRQILNYVNQAV---KEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLT 1016

Query: 643  ELGCRRGGVLF--ASRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPD 700
            +      G L    +R +   L  LL  D+L++ Q K   RL +    H  ++ +     
Sbjct: 1017 KRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQ-KQDDRLVL--RCHSKILASTADSK 1073

Query: 701  PSGPPTFRLSLLSNHQGRPTHRLLQASSLSD 731
             +  P  +LS +   Q    ++ L   S+SD
Sbjct: 1074 HTFSPVIKLSTVLVRQVATDNKALFVISMSD 1104


>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
           isoform 1 [Homo sapiens]
          Length = 1279

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 72/278 (25%), Positives = 119/278 (42%), Gaps = 11/278 (3%)

Query: 400 PAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTF--VLSQALRDTLTPRD 457
           PA +   + + LSPQ+   +  L  +V SE SY+ SL+ +   +   L +     L+ R 
Sbjct: 299 PAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARK 358

Query: 458 HHTLFSNVQRVQGVSERFLATLLSRVR---SSPHISDLCDVVHAHAVGPFSVYVDYVRNQ 514
              +F  V+ +      F   L SRV    S+  I DL     + ++    VY DYV N 
Sbjct: 359 CQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSM-VLDVYSDYVNNF 417

Query: 515 QYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQT 574
                   +   T   F   L+R Q     +R+ L   ++ P QR  +  +LLQ++L+ T
Sbjct: 418 TSAMSIIKKACLTKPAFLEFLKRRQVCSP-DRVTLYGLMVKPIQRFPQFILLLQDMLKNT 476

Query: 575 EEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRR 634
             G   + + Q AL  +  + E+ + +     Q  E+ +LT+ +         L S  R+
Sbjct: 477 PRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQ 536

Query: 635 LEFQGELTELGCRRGGVLFASRPRFTPLCLLLFSDLLL 672
           L     LTE      G L  S+ R     + L +D+L+
Sbjct: 537 LLLCETLTETVYGDRGQLIKSKER----RVFLLNDMLV 570


>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
           isoform 2 [Homo sapiens]
          Length = 1240

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 72/278 (25%), Positives = 119/278 (42%), Gaps = 11/278 (3%)

Query: 400 PAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTF--VLSQALRDTLTPRD 457
           PA +   + + LSPQ+   +  L  +V SE SY+ SL+ +   +   L +     L+ R 
Sbjct: 260 PAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARK 319

Query: 458 HHTLFSNVQRVQGVSERFLATLLSRVR---SSPHISDLCDVVHAHAVGPFSVYVDYVRNQ 514
              +F  V+ +      F   L SRV    S+  I DL     + ++    VY DYV N 
Sbjct: 320 CQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSM-VLDVYSDYVNNF 378

Query: 515 QYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQT 574
                   +   T   F   L+R Q     +R+ L   ++ P QR  +  +LLQ++L+ T
Sbjct: 379 TSAMSIIKKACLTKPAFLEFLKRRQVCSP-DRVTLYGLMVKPIQRFPQFILLLQDMLKNT 437

Query: 575 EEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRR 634
             G   + + Q AL  +  + E+ + +     Q  E+ +LT+ +         L S  R+
Sbjct: 438 PRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQ 497

Query: 635 LEFQGELTELGCRRGGVLFASRPRFTPLCLLLFSDLLL 672
           L     LTE      G L  S+ R     + L +D+L+
Sbjct: 498 LLLCETLTETVYGDRGQLIKSKER----RVFLLNDMLV 531


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 102/395 (25%), Positives = 168/395 (42%), Gaps = 41/395 (10%)

Query: 351 PLYQTYRAAVLSEELWGVGEDGSPSPA-NAGDAPTFPRP-PGPRNTLWQELPAVQASGLL 408
           P   + R +  S  L  VG +G P+P      + + P P PGP   L   L  V   G  
Sbjct: 41  PTMASPRGSGSSTSLSTVGSEGDPAPGPTPACSASRPEPLPGPPIRL--HLSPVGIPG-- 96

Query: 409 DTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFV--LSQALRDTLTPRDHHTLFSNVQ 466
              S +  R++    E+V +E +Y+R LR + + ++  L       L+     TLF+N++
Sbjct: 97  ---SARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIE 153

Query: 467 RVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMD 526
            +   S   L  L     S+  I++ C V  +     F +Y  Y  N      + + L +
Sbjct: 154 DIYEFSSELLEDL-ENSSSAGGIAE-CFVQRSE---DFDIYTLYCMNYP---SSLALLRE 205

Query: 527 TNVRFSAELRRLQSLPKCER-LPLPSFLLLPFQRITRLRMLLQNILRQTEE--GSSRQEN 583
            ++   A L   +   +    LPL SFLL P QRI +  +LLQ + +   E  G+  +E 
Sbjct: 206 LSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREM 265

Query: 584 AQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWS-RRLEFQGELT 642
            ++A+ +++ +    +  +  MK+ +E     Q ++        L  W+   L   GEL 
Sbjct: 266 VEEAIVSMTAV----AWYINDMKRKQEHAARLQEVQRR------LGGWTGPELSAFGELV 315

Query: 643 ELGCRRGGVLFASRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPS 702
             G  RGG     R R     L LFS +LL+ + +    L+     H           P 
Sbjct: 316 LEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRG---LEYTYKGHIFCCNLSVSESPR 372

Query: 703 GPPTFRLSLLSNHQGRPTHR-LLQASSLSDMQRWL 736
            P  F++S L+     P HR LLQA +  + + W+
Sbjct: 373 DPLGFKVSDLT----IPKHRHLLQAKNQEEKRLWI 403



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 37/132 (28%), Positives = 52/132 (39%), Gaps = 22/132 (16%)

Query: 6    LPAATPPTQKPPRI----IRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTPI 61
            +PAATP  ++   +    + P P   +     PG    GS    + R  +   TP  +P 
Sbjct: 1208 VPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPG----GSLASHVARLESSDLTPPHSP- 1262

Query: 62   FWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSP------VSRRSASPEPAPR 115
               PP++      LL P+A+  S     S  S S      P       SR S S  P  R
Sbjct: 1263 ---PPSSR----QLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSR 1315

Query: 116  SPVPPPKPSGSP 127
            +  PPP+P   P
Sbjct: 1316 ASSPPPQPQPPP 1327



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 53/194 (27%), Positives = 66/194 (34%), Gaps = 27/194 (13%)

Query: 6   LPAATPPTQKP-PRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTPIFWE 64
           L   TPP   P PR  R   P R   A SPGP         + R       P+  P    
Sbjct: 441 LEPLTPPLGSPRPRDARSFTPGRRNTAPSPGP--------SVIRRGRRQSEPVKDPYVMF 492

Query: 65  PPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRSASPEPAPRSPVPPPKPS 124
           P  A         P    A  + +  P  P S P   PVS  SA PE    +  P   PS
Sbjct: 493 PQNAK--------PGFKHAGSEGELYP--PESQP---PVS-GSAPPEDLEDAGPPTLDPS 538

Query: 125 GSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEGRAQDADAPEPGLQARADVNGE 184
           G+  T    +  +L Q G    PG       +F G ++            L +R D + E
Sbjct: 539 GTSITE--EILELLNQRGLRD-PGPSTHDIPKFPGDSQVPGDSETLTFQALPSR-DSSEE 594

Query: 185 REAPLTGSGSQENG 198
            E    G    E G
Sbjct: 595 EEEEEEGLEMDERG 608


>gi|222080070 pleckstrin homology domain-containing family G member
           6 isoform b [Homo sapiens]
          Length = 758

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 89/351 (25%), Positives = 146/351 (41%), Gaps = 29/351 (8%)

Query: 411 LSPQERRMQESLFEVVTSEASYLRSLRLLTDTF---VLSQALRDTLTPRDHHTLFSNVQR 467
           +S +    QE+L+E++T+E  Y+R L+++TD     +L+      L      TLF NV  
Sbjct: 123 MSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPS 182

Query: 468 VQGVSERF----LATLLSRVRSSPHISDLCDVVHAHAV--GPFSVYVDYVRNQQYQEETY 521
           +      F    L   L   R+S    D   +          F  YV Y    + Q   Y
Sbjct: 183 LIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVK-QTMAY 241

Query: 522 SR-LMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSR 580
           +R   +TN  F A ++  +   +  R  L   L+ P QRIT+  +LL  +L+++ E  + 
Sbjct: 242 AREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARA- 300

Query: 581 QENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALP------------- 627
           QE     + AV   +   + +V + ++ E L    QR+  ++V   P             
Sbjct: 301 QEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFST 360

Query: 628 LVSWSRRLEFQGELTELGCRRGGV-LFASRPRFTPLCLLLFSDLLLITQPKSGQRLQVLD 686
           L   S  L    E T      G V +   R     + L LFSD+LL+T+P+  ++     
Sbjct: 361 LDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQ--RKADKAK 418

Query: 687 YAHRSLVQAQQVPDP-SGPPTFRLSLLSNHQGRPTHRLLQASSLSDMQRWL 736
                L+  + V  P   P +F L  L+  Q   +  L+   S +D  +WL
Sbjct: 419 VIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWL 469


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,704,074
Number of Sequences: 37866
Number of extensions: 2687130
Number of successful extensions: 33002
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 507
Number of HSP's successfully gapped in prelim test: 1794
Number of HSP's that attempted gapping in prelim test: 15020
Number of HSP's gapped (non-prelim): 11360
length of query: 841
length of database: 18,247,518
effective HSP length: 111
effective length of query: 730
effective length of database: 14,044,392
effective search space: 10252406160
effective search space used: 10252406160
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.