Search of human proteins with 31621309

Search of human proteins with 31621309

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31621309 leucine rich repeat containing 6 [Homo sapiens]
         (466 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31621309 leucine rich repeat containing 6 [Homo sapiens]           943   0.0  
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  94   2e-19
gi|55743114 leucine rich repeat containing 49 [Homo sapiens]           76   6e-14
gi|239752518 PREDICTED: similar to leucine rich repeat containin...    75   1e-13
gi|15529980 leucine rich repeat containing 46 [Homo sapiens]           72   1e-12
gi|157674358 leucine rich repeat containing 50 [Homo sapiens]          70   5e-12
gi|194272228 leucine rich repeat containing 48 isoform b [Homo s...    69   7e-12
gi|194272226 leucine rich repeat containing 48 isoform b [Homo s...    69   7e-12
gi|194272224 leucine rich repeat containing 48 isoform a [Homo s...    69   7e-12
gi|194272222 leucine rich repeat containing 48 isoform a [Homo s...    69   7e-12
gi|21389483 leucine-rich repeats and guanylate kinase domain con...    67   5e-11
gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 fami...    66   6e-11
gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 famil...    65   1e-10
gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo sap...    63   5e-10
gi|210147571 acidic (leucine-rich) nuclear phosphoprotein 32 fam...    62   1e-09
gi|206725447 leucine rich repeat containing 23 isoform a [Homo s...    62   1e-09
gi|42542396 leucine rich repeat containing 23 isoform a [Homo sa...    62   1e-09
gi|117414162 sodium channel associated protein 2 isoform a [Homo...    60   4e-09
gi|239735605 leucine rich repeat containing 36 isoform 1 [Homo s...    58   2e-08
gi|31377705 centrosomal protein 97kDa [Homo sapiens]                   58   2e-08
gi|4826651 hypothetical protein LOC755 [Homo sapiens]                  57   3e-08
gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 famil...    54   3e-07
gi|50593002 small nuclear ribonucleoprotein polypeptide A' [Homo...    54   4e-07
gi|61966709 leucine rich repeat containing 67 [Homo sapiens]           50   3e-06
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof...    48   2e-05
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof...    48   2e-05
gi|66472382 nischarin [Homo sapiens]                                   47   3e-05
gi|239756368 PREDICTED: similar to acidic (leucine-rich) nuclear...    46   8e-05
gi|239750893 PREDICTED: similar to acidic (leucine-rich) nuclear...    46   8e-05
gi|210147569 acidic (leucine-rich) nuclear phosphoprotein 32 fam...    46   8e-05

>gi|31621309 leucine rich repeat containing 6 [Homo sapiens]
          Length = 466

 Score =  943 bits (2437), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 1   MGWITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIE 60
           MGWITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIE
Sbjct: 1   MGWITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIE 60

Query: 61  NVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL 120
           NVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL
Sbjct: 61  NVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL 120

Query: 121 MGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKR 180
           MGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKR
Sbjct: 121 MGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKR 180

Query: 181 AKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKL 240
           AKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKL
Sbjct: 181 AKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKL 240

Query: 241 DNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEKLSEKKKKVKPPRTLITEDGKALN 300
           DNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEKLSEKKKKVKPPRTLITEDGKALN
Sbjct: 241 DNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEKLSEKKKKVKPPRTLITEDGKALN 300

Query: 301 VNEPKIDFSLKDNEKQIILDLAVYRYMDTSLIDVDVQPTYVRVMIKGKPFQLVLPAEVKP 360
           VNEPKIDFSLKDNEKQIILDLAVYRYMDTSLIDVDVQPTYVRVMIKGKPFQLVLPAEVKP
Sbjct: 301 VNEPKIDFSLKDNEKQIILDLAVYRYMDTSLIDVDVQPTYVRVMIKGKPFQLVLPAEVKP 360

Query: 361 DSSSAKRSQTTGHLVICMPKVGEVITGGQRAFKSMKTTSDRSREQTNTRSKHMEKLEVDP 420
           DSSSAKRSQTTGHLVICMPKVGEVITGGQRAFKSMKTTSDRSREQTNTRSKHMEKLEVDP
Sbjct: 361 DSSSAKRSQTTGHLVICMPKVGEVITGGQRAFKSMKTTSDRSREQTNTRSKHMEKLEVDP 420

Query: 421 SKHSFPDVTNIVQEKKHTPRRRPEPKIIPSEEDPTFEDNPEVPPLI 466
           SKHSFPDVTNIVQEKKHTPRRRPEPKIIPSEEDPTFEDNPEVPPLI
Sbjct: 421 SKHSFPDVTNIVQEKKHTPRRRPEPKIIPSEEDPTFEDNPEVPPLI 466


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 93/366 (25%), Positives = 167/366 (45%), Gaps = 41/366 (11%)

Query: 3   WITEDLIRRNAEHNDCVIFSLEELSLHQ---QEIERLEHIDKWCRDLKILYLQNNLIGKI 59
           +ITE LI++  + ++  +     LSL +   ++ + +E+++K C  L++L L  NLIGKI
Sbjct: 82  YITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEK-CVKLEVLNLSYNLIGKI 140

Query: 60  ENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGEL---------------- 103
           E + KL KL  LNL+ N I KIE +E    L KL+L  N I  +                
Sbjct: 141 EKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNL 200

Query: 104 --SSIKNLQHNIHLK------ELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSER 155
             + I +LQ    LK       L L+ NP  +  HY +F +  L  L+ L+G+ +   +R
Sbjct: 201 KGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDR 260

Query: 156 IKALQDYSVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWY--TD 213
            +A + +S+ E +  E++ +  +   +  +  Q +  EE KN+DK + +  +        
Sbjct: 261 QEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQS 320

Query: 214 INATLSSLESKDHLQAPDTEE--HNTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQ 271
                S L +K+ L    T E     +K    E +L F+     F P +   +  + E  
Sbjct: 321 CEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPS-EYAEID 379

Query: 272 RKKQEK----LSEKKKKVKPPRTLITEDGKALNVNEPKIDFSLKDNEKQIILDLAVYRYM 327
           +   E      S  K+ +    + I +  +A+ + + + D  L+++     ++L  +  +
Sbjct: 380 KAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDH----MNLRGHTPL 435

Query: 328 DTSLID 333
           DT L D
Sbjct: 436 DTQLED 441


>gi|55743114 leucine rich repeat containing 49 [Homo sapiens]
          Length = 686

 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 51/161 (31%), Positives = 79/161 (49%), Gaps = 1/161 (0%)

Query: 22  SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
           SL+ L LH  +I ++E+I+  C +L++L L  N +  ++N++ L  L  LNL  N I  +
Sbjct: 179 SLDVLDLHGNQITKIENINHLC-ELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFV 237

Query: 82  ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
            +++    L  L L+ N I    S+  L  +  L ++   GNP A    Y+  V+  + Q
Sbjct: 238 RDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQ 297

Query: 142 LKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAK 182
           L+ LD K I   ER  A       E + RE  K   LK  K
Sbjct: 298 LRQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKK 338



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 77/346 (22%), Positives = 145/346 (41%), Gaps = 29/346 (8%)

Query: 8   LIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKK 67
           +++R++E    +++S + LSL +Q++     I+     L++L  Q+N I +I+N+S L+K
Sbjct: 80  ILQRSSEEK--ILYS-DRLSLERQKLTVCPIINGEDH-LRLLNFQHNFITRIQNISNLQK 135

Query: 68  LEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCAS 127
           L  L+L  N IE+I  L     L  L L  N I ++S+++NL+    L  L L GN    
Sbjct: 136 LISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLK---SLDVLDLHGNQITK 192

Query: 128 FDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQI---REQEKDHCLKRAKLK 184
            ++        +  L       ++    + +L + ++   QI   R+ +   CL+   L 
Sbjct: 193 IENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLS 252

Query: 185 EEAQRKHQEED--KNEDKRSNAGFDGR------WYT-DINATLSSLESKDHLQAPDTEEH 235
                         +    S+  FDG       WY   +   +  L   D  +  + E  
Sbjct: 253 FNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERR 312

Query: 236 NTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEK------LSEKKKKVKPPR 289
               L   E++ +  +       E +  T+ ++ +Q   Q++       +E +K    P+
Sbjct: 313 MASVLAKKEEEKKRESHKQSLLKEKKRLTINNVARQWDLQQQRVANIATNEDRKDSDSPQ 372

Query: 290 TLITEDGKALNVNEPKIDFSLKDNEKQIILDLAVYRYMDTSLIDVD 335
                DG  L+   P+    L       +  L+V   +DT L++VD
Sbjct: 373 DPCQIDGSTLSA-FPEETGPLDSGLNNALQGLSV---IDTYLVEVD 414


>gi|239752518 PREDICTED: similar to leucine rich repeat containing
           50, partial [Homo sapiens]
          Length = 489

 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 50/161 (31%), Positives = 79/161 (49%), Gaps = 1/161 (0%)

Query: 22  SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
           +L+ L LH  +I ++E+I+  C +L++L L  N +  ++N++ L  L  LNL  N I  +
Sbjct: 4   NLDVLDLHGNQITKIENINHLC-ELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFV 62

Query: 82  ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
            +++    L  L L+ N I    S+  L  +  L ++   GNP A    Y+  V+  + Q
Sbjct: 63  RDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQ 122

Query: 142 LKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAK 182
           L+ LD K I   ER  A       E + RE  K   LK  K
Sbjct: 123 LRQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKK 163


>gi|15529980 leucine rich repeat containing 46 [Homo sapiens]
          Length = 321

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 65/202 (32%), Positives = 102/202 (50%), Gaps = 17/202 (8%)

Query: 4   ITEDLIRR-------NAEHNDCVIFSLEELS---LHQQEIERLEHIDKWCRDLKILYLQN 53
           ITE LI +       + E ++ +  +L+EL    L ++ I  + +++   ++L  LYLQ 
Sbjct: 17  ITEALITKRNLTFPEDGELSEKMFHTLDELQTVRLDREGITTIRNLEG-LQNLHSLYLQG 75

Query: 54  NLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNI 113
           N I +IEN++ +  L +L+LA N I ++ENL     L  LDL+ N I    ++K  +   
Sbjct: 76  NKIQQIENLACIPSLRFLSLAGNQIRQVENLLDLPCLQFLDLSENLI---ETLKLDEFPQ 132

Query: 114 HLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQE 173
            L  L L GN C + D YRE V   LP L  LDG+ +     I   +D +  + +  E  
Sbjct: 133 SLLILNLSGNSCTNQDGYRELVTEALPLLLDLDGQPV-VERWISDEEDEASSDEEFPELS 191

Query: 174 KDHCLKRAKLKEEAQR--KHQE 193
              C +R  LKE  Q   +H+E
Sbjct: 192 GPFCSERGFLKELEQELSRHRE 213


>gi|157674358 leucine rich repeat containing 50 [Homo sapiens]
          Length = 725

 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 59/220 (26%), Positives = 99/220 (45%), Gaps = 38/220 (17%)

Query: 26  LSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIEN-- 83
           L L    I+++E+++    +L+ L+LQ NL+ KIEN+  L+KL+ LNL+ N I+ IEN  
Sbjct: 134 LWLQSNGIQKIENLEAQT-ELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLS 192

Query: 84  -----------------------LEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL 120
                                  L+ C  L  LDL+ N + +   +  L+    L+ L L
Sbjct: 193 CLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNL 252

Query: 121 MGNP-CASFDHYREFVVATLPQLKWLDGKEIEPSERIKA-----------LQDYSVIEPQ 168
           MGNP      +YR  V   L  L +LD + + P +R  A            ++    E +
Sbjct: 253 MGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAEKEERQQWESR 312

Query: 169 IREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDG 208
            R++  D     A +K+ A+ + ++ +  E     +  DG
Sbjct: 313 ERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDG 352



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 37/115 (32%), Positives = 56/115 (48%), Gaps = 10/115 (8%)

Query: 49  LYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKN 108
           LYL      +IEN+ +   L  L L  N I+KIENLE   EL  L L +N + ++ +++ 
Sbjct: 112 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEP 171

Query: 109 LQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLD--GKEIEPSERIKALQD 161
           LQ    L  L L  N   + ++     ++ LP L  L      +E  E I+ LQ+
Sbjct: 172 LQ---KLDALNLSNNYIKTIEN-----LSCLPVLNTLQMAHNHLETVEDIQHLQE 218


>gi|194272228 leucine rich repeat containing 48 isoform b [Homo
           sapiens]
          Length = 457

 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 75/263 (28%), Positives = 122/263 (46%), Gaps = 25/263 (9%)

Query: 22  SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
           +L +L L    IE++E ++     L  L L  N I  IE +  L  LE L+L  N I KI
Sbjct: 66  NLRKLQLDNNIIEKIEGLENLAH-LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI 124

Query: 82  ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
           ++L+   +L  L L  N I  + +I  L+    L+ L L  NP +  + Y+ F+ A LP 
Sbjct: 125 DSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPD 184

Query: 142 LKWLDGKEIEPSER--IKALQDYSVIEPQIREQEKDHCLKRAKLK-EEAQRKHQEEDKNE 198
           L +LD + I+   +   +A   YS+ E  ++ QE    L +A+L+ E+AQR+  E+ K  
Sbjct: 185 LMYLDYRRIDDHTKKLAEAKHQYSIDE--LKHQEN---LMQAQLEDEQAQREELEKHK-- 237

Query: 199 DKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLEFWNKPCLFTP 258
                        T     L+     D + A D+E +N   L    + LE +    +   
Sbjct: 238 -------------TAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIIC 284

Query: 259 ESRLE-TLRHMEKQRKKQEKLSE 280
            +  E  L+  EK++ + +  SE
Sbjct: 285 VNIFEYGLKQQEKRKTELDTFSE 307


>gi|194272226 leucine rich repeat containing 48 isoform b [Homo
           sapiens]
          Length = 457

 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 75/263 (28%), Positives = 122/263 (46%), Gaps = 25/263 (9%)

Query: 22  SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
           +L +L L    IE++E ++     L  L L  N I  IE +  L  LE L+L  N I KI
Sbjct: 66  NLRKLQLDNNIIEKIEGLENLAH-LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI 124

Query: 82  ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
           ++L+   +L  L L  N I  + +I  L+    L+ L L  NP +  + Y+ F+ A LP 
Sbjct: 125 DSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPD 184

Query: 142 LKWLDGKEIEPSER--IKALQDYSVIEPQIREQEKDHCLKRAKLK-EEAQRKHQEEDKNE 198
           L +LD + I+   +   +A   YS+ E  ++ QE    L +A+L+ E+AQR+  E+ K  
Sbjct: 185 LMYLDYRRIDDHTKKLAEAKHQYSIDE--LKHQEN---LMQAQLEDEQAQREELEKHK-- 237

Query: 199 DKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLEFWNKPCLFTP 258
                        T     L+     D + A D+E +N   L    + LE +    +   
Sbjct: 238 -------------TAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIIC 284

Query: 259 ESRLE-TLRHMEKQRKKQEKLSE 280
            +  E  L+  EK++ + +  SE
Sbjct: 285 VNIFEYGLKQQEKRKTELDTFSE 307


>gi|194272224 leucine rich repeat containing 48 isoform a [Homo
           sapiens]
          Length = 523

 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 75/263 (28%), Positives = 122/263 (46%), Gaps = 25/263 (9%)

Query: 22  SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
           +L +L L    IE++E ++     L  L L  N I  IE +  L  LE L+L  N I KI
Sbjct: 66  NLRKLQLDNNIIEKIEGLENLAH-LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI 124

Query: 82  ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
           ++L+   +L  L L  N I  + +I  L+    L+ L L  NP +  + Y+ F+ A LP 
Sbjct: 125 DSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPD 184

Query: 142 LKWLDGKEIEPSER--IKALQDYSVIEPQIREQEKDHCLKRAKLK-EEAQRKHQEEDKNE 198
           L +LD + I+   +   +A   YS+ E  ++ QE    L +A+L+ E+AQR+  E+ K  
Sbjct: 185 LMYLDYRRIDDHTKKLAEAKHQYSIDE--LKHQEN---LMQAQLEDEQAQREELEKHK-- 237

Query: 199 DKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLEFWNKPCLFTP 258
                        T     L+     D + A D+E +N   L    + LE +    +   
Sbjct: 238 -------------TAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIIC 284

Query: 259 ESRLE-TLRHMEKQRKKQEKLSE 280
            +  E  L+  EK++ + +  SE
Sbjct: 285 VNIFEYGLKQQEKRKTELDTFSE 307


>gi|194272222 leucine rich repeat containing 48 isoform a [Homo
           sapiens]
          Length = 523

 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 75/263 (28%), Positives = 122/263 (46%), Gaps = 25/263 (9%)

Query: 22  SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
           +L +L L    IE++E ++     L  L L  N I  IE +  L  LE L+L  N I KI
Sbjct: 66  NLRKLQLDNNIIEKIEGLENLAH-LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI 124

Query: 82  ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
           ++L+   +L  L L  N I  + +I  L+    L+ L L  NP +  + Y+ F+ A LP 
Sbjct: 125 DSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPD 184

Query: 142 LKWLDGKEIEPSER--IKALQDYSVIEPQIREQEKDHCLKRAKLK-EEAQRKHQEEDKNE 198
           L +LD + I+   +   +A   YS+ E  ++ QE    L +A+L+ E+AQR+  E+ K  
Sbjct: 185 LMYLDYRRIDDHTKKLAEAKHQYSIDE--LKHQEN---LMQAQLEDEQAQREELEKHK-- 237

Query: 199 DKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLEFWNKPCLFTP 258
                        T     L+     D + A D+E +N   L    + LE +    +   
Sbjct: 238 -------------TAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIIC 284

Query: 259 ESRLE-TLRHMEKQRKKQEKLSE 280
            +  E  L+  EK++ + +  SE
Sbjct: 285 VNIFEYGLKQQEKRKTELDTFSE 307


>gi|21389483 leucine-rich repeats and guanylate kinase domain
           containing [Homo sapiens]
          Length = 825

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 47/141 (33%), Positives = 75/141 (53%), Gaps = 2/141 (1%)

Query: 22  SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
           +L  LSL   +I  +  ++K    +KIL L NN I  I  +  LK L+ L+L+ N I  +
Sbjct: 238 NLIHLSLANNKITTINGLNKL--PIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSL 295

Query: 82  ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
           + LE  + L  ++L  N I EL  I+ +++   L+ L L+ NP      Y  FV+  L +
Sbjct: 296 QGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLR 355

Query: 142 LKWLDGKEIEPSERIKALQDY 162
           L  LD K+I+  E++ A+  Y
Sbjct: 356 LTELDQKKIKVEEKVSAVNKY 376



 Score = 37.0 bits (84), Expect = 0.038
 Identities = 43/155 (27%), Positives = 66/155 (42%), Gaps = 11/155 (7%)

Query: 18  CVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNN 77
           C    L++L L   +IE L  +      L++   QNNL     N    K L+  + + N 
Sbjct: 146 CGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLT-TFFNFKPPKNLKKADFSHNQ 204

Query: 78  IEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVA 137
           I +I +L     L KL L  N I E+S ++   + IHL    L  N   + +   +  + 
Sbjct: 205 ISEICDLSAYHALTKLILDGNEIEEISGLEMCNNLIHLS---LANNKITTINGLNKLPIK 261

Query: 138 TLPQLKWLDGKEIE---PSERIKALQDYSVIEPQI 169
            L     L   +IE     E +KALQ+  +   QI
Sbjct: 262 IL----CLSNNQIEMITGLEDLKALQNLDLSHNQI 292


>gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member E isoform 1 [Homo sapiens]
          Length = 268

 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 57/239 (23%), Positives = 115/239 (48%), Gaps = 4/239 (1%)

Query: 11  RNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEY 70
           RN    +     L+       EIE L    K    L +  ++ + + ++ +++KL+KLE 
Sbjct: 12  RNRSPEEVTELVLDNCLCVNGEIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKLEL 71

Query: 71  L-NLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFD 129
             N+    +E +   E C  L  L+L+ N I +LS+++ LQ+  +LK L L      + +
Sbjct: 72  SDNIISGGLEVLA--EKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDLFNCEITNLE 129

Query: 130 HYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKLKEEAQR 189
            YRE +   L Q+ +LDG + E +E   + ++      +  E+E+++     +  EE + 
Sbjct: 130 DYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDEDGDEDDEEEEENEAGPPEGYEEEEE 189

Query: 190 KHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLE 248
           + +EED++ED+  +         +    LS L  K+ +Q  + ++   ++ +  E++ E
Sbjct: 190 EEEEEDEDEDEDEDEAGSELGEGEEEVGLSYL-MKEEIQDEEDDDDYVEEGEEEEEEEE 247


>gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member A [Homo sapiens]
          Length = 249

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 61/216 (28%), Positives = 100/216 (46%), Gaps = 23/216 (10%)

Query: 35  RLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEK-IENL-EGCEELAK 92
           +LE +     +L+ L   N  +  I N+ KL KL+ L L+ N +   +E L E C  L  
Sbjct: 33  KLEGLTDEFEELEFLSTINVGLTSIANLPKLNKLKKLELSDNRVSGGLEVLAEKCPNLTH 92

Query: 93  LDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEP 152
           L+L+ N I +LS+I+ L+   +LK L L      + + YRE V   LPQL +LDG + + 
Sbjct: 93  LNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLNDYRENVFKLLPQLTYLDGYDRDD 152

Query: 153 SERIKALQDYSVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYT 212
            E   +  +  V      E+++D      +  E+AQ    EED++E++            
Sbjct: 153 KEAPDSDAEGYVEGLDDEEEDED----EEEYDEDAQVVEDEEDEDEEEEGEE-------- 200

Query: 213 DINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLE 248
                    E     +  D E +N  ++D+ ED+ E
Sbjct: 201 ---------EDVSGEEEEDEEGYNDGEVDDEEDEEE 227


>gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo
           sapiens]
          Length = 360

 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 45/142 (31%), Positives = 78/142 (54%), Gaps = 13/142 (9%)

Query: 24  EELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIEN 83
           E++ L+   I ++E  +   + +K L L+ NLI  IEN+ +L+ L  L+L  N I+KIEN
Sbjct: 79  EDVDLNHYRIGKIEGFEV-LKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIEN 137

Query: 84  LEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLK 143
           LE   EL  LD++ N +  +  +  L     LK+LFL+ N  +  ++     ++ L QL+
Sbjct: 138 LEALTELEILDISFNLLRNIEGVDKL---TRLKKLFLVNNKISKIEN-----LSNLHQLQ 189

Query: 144 WLDGKEIEPSERIKALQDYSVI 165
            L+      S RI+A+++   +
Sbjct: 190 MLE----LGSNRIRAIENIDTL 207



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 45/152 (29%), Positives = 75/152 (49%), Gaps = 6/152 (3%)

Query: 10  RRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLE 69
           R  A  N   + +LE L L + +I +L+++D    +L +L +Q+N + KIE +  L  L 
Sbjct: 197 RIRAIENIDTLTNLESLFLGKNKITKLQNLDA-LTNLTVLSMQSNRLTKIEGLQNLVNLR 255

Query: 70  YLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFD 129
            L L+ N IE IE LE   +L  LD+  N    +  I+N+ H   L+E ++  N   S+ 
Sbjct: 256 ELYLSHNGIEVIEGLENNNKLTMLDIASN---RIKKIENISHLTELQEFWMNDNLLESWS 312

Query: 130 HYREFVVATLPQLKWLDGKEI--EPSERIKAL 159
              E   A   +  +L+   +  +P  R K +
Sbjct: 313 DLDELKGARSLETVYLERNPLQKDPQYRRKVM 344



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 37/125 (29%), Positives = 63/125 (50%), Gaps = 1/125 (0%)

Query: 22  SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
           +L  LS+    + ++E +     +L+ LYL +N I  IE +    KL  L++A N I+KI
Sbjct: 231 NLTVLSMQSNRLTKIEGLQNLV-NLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKI 289

Query: 82  ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
           EN+    EL +  +  N +   S +  L+    L+ ++L  NP      YR  V+  LP 
Sbjct: 290 ENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPS 349

Query: 142 LKWLD 146
           ++ +D
Sbjct: 350 VRQID 354



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 48/159 (30%), Positives = 72/159 (45%), Gaps = 20/159 (12%)

Query: 23  LEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIE 82
           LE L +    +  +E +DK  R LK L+L NN I KIEN+S L +L+ L L  N I  IE
Sbjct: 144 LEILDISFNLLRNIEGVDKLTR-LKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIE 202

Query: 83  NLEGCEELAKLDLTVNFI-------------------GELSSIKNLQHNIHLKELFLMGN 123
           N++    L  L L  N I                     L+ I+ LQ+ ++L+EL+L  N
Sbjct: 203 NIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN 262

Query: 124 PCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDY 162
                +        T+  +     K+IE    +  LQ++
Sbjct: 263 GIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEF 301


>gi|210147571 acidic (leucine-rich) nuclear phosphoprotein 32
           family, member E isoform 3 [Homo sapiens]
          Length = 220

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 48/194 (24%), Positives = 100/194 (51%), Gaps = 4/194 (2%)

Query: 56  IGKIENVSKLKKLEYL-NLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIH 114
           + ++ +++KL+KLE   N+    +E +   E C  L  L+L+ N I +LS+++ LQ+  +
Sbjct: 9   LARLPSLNKLRKLELSDNIISGGLEVLA--EKCPNLTYLNLSGNKIKDLSTVEALQNLKN 66

Query: 115 LKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEK 174
           LK L L      + + YRE +   L Q+ +LDG + E +E   + ++      +  E+E+
Sbjct: 67  LKSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDEDGDEDDEEEE 126

Query: 175 DHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEE 234
           ++     +  EE + + +EED++ED+  +         +    LS L  K+ +Q  + ++
Sbjct: 127 ENEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYL-MKEEIQDEEDDD 185

Query: 235 HNTKKLDNSEDDLE 248
              ++ +  E++ E
Sbjct: 186 DYVEEGEEEEEEEE 199


>gi|206725447 leucine rich repeat containing 23 isoform a [Homo
           sapiens]
          Length = 343

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 46/168 (27%), Positives = 79/168 (47%), Gaps = 7/168 (4%)

Query: 20  IFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIE 79
           + SL  + L   ++E    I+     LK LYL  N++ K+E +  L  L  L+L  N I+
Sbjct: 178 LISLHTVELRGNQLESTLGIN--LPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQID 235

Query: 80  KIENLEG-CEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVAT 138
            +       + L  L+L  N +  L  +  L+    L+ L L+ NPC     YR+  +  
Sbjct: 236 TLSGFSREMKSLQYLNLRGNMVANLGELAKLRDLPKLRALVLLDNPCTDETSYRQEALVQ 295

Query: 139 LPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKLKEE 186
           +P L+ LD +  E  ER +A     VI  +++E+++     +  L+ E
Sbjct: 296 MPYLERLDKEFYEEEERAEA----DVIRQRLKEEKEQEPEPQRDLEPE 339


>gi|42542396 leucine rich repeat containing 23 isoform a [Homo
           sapiens]
          Length = 343

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 46/168 (27%), Positives = 79/168 (47%), Gaps = 7/168 (4%)

Query: 20  IFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIE 79
           + SL  + L   ++E    I+     LK LYL  N++ K+E +  L  L  L+L  N I+
Sbjct: 178 LISLHTVELRGNQLESTLGIN--LPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQID 235

Query: 80  KIENLEG-CEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVAT 138
            +       + L  L+L  N +  L  +  L+    L+ L L+ NPC     YR+  +  
Sbjct: 236 TLSGFSREMKSLQYLNLRGNMVANLGELAKLRDLPKLRALVLLDNPCTDETSYRQEALVQ 295

Query: 139 LPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKLKEE 186
           +P L+ LD +  E  ER +A     VI  +++E+++     +  L+ E
Sbjct: 296 MPYLERLDKEFYEEEERAEA----DVIRQRLKEEKEQEPEPQRDLEPE 339


>gi|117414162 sodium channel associated protein 2 isoform a [Homo
           sapiens]
          Length = 1032

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 50/161 (31%), Positives = 76/161 (47%), Gaps = 34/161 (21%)

Query: 22  SLEELSLHQQEIERLEHIDK-WCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEK 80
           +L  ++LH   I ++E ID  W  +L+ L L +N I +IE ++ L KL  LNL+ N I K
Sbjct: 44  TLHAVNLHCNNISKIEAIDHIW--NLQHLDLSSNQISRIEGLNTLTKLCTLNLSCNLITK 101

Query: 81  IENLEGCEELAKLDLTVNFIGELSSI---KNLQHNIHLKEL------------------- 118
           +E LE    L +L+++ N I +LS +     ++H +   +L                   
Sbjct: 102 VEGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLH 161

Query: 119 FLMG---------NPCASFDHYREFVVATLPQLKWLDGKEI 150
           FL           NP      YR  ++ TLPQL+ LD K I
Sbjct: 162 FLTNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNI 202



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 4/80 (5%)

Query: 30  QQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEE 89
           + E+E  E  D  C D  + ++   L   I  +S    L  +NL  NNI KIE ++    
Sbjct: 11  EAEVEN-EDGDSSCGD--VCFMDKGL-QSISELSLDSTLHAVNLHCNNISKIEAIDHIWN 66

Query: 90  LAKLDLTVNFIGELSSIKNL 109
           L  LDL+ N I  +  +  L
Sbjct: 67  LQHLDLSSNQISRIEGLNTL 86


>gi|239735605 leucine rich repeat containing 36 isoform 1 [Homo
           sapiens]
          Length = 754

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 66/230 (28%), Positives = 100/230 (43%), Gaps = 17/230 (7%)

Query: 24  EELSLHQQEIERLEHIDKWCRDL-KILYLQNNLIGKIENVS----KLKKLEYLNLALNNI 78
           E+  L ++ I RL  +     +L + L LQ +  GKI ++       K L  L+L+ N I
Sbjct: 3   EQWELDEEGIRRLGALTLEQPELVESLSLQGSYAGKIHSIGDAFRNFKNLRSLDLSRNLI 62

Query: 79  EKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFD-HYREFVVA 137
             ++ ++    L  L+L  N I  L  +  LQ    LKEL L  NP    D  YR F V 
Sbjct: 63  TSLKGIQYLCSLQDLNLYYNNIPSLVEVSRLQPLPFLKELDLRLNPVVRKDTDYRLFAVY 122

Query: 138 TLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKN 197
           TL  L+ LD + +   ER  A   +S +        ++  L+  K   E   K+    ++
Sbjct: 123 TLQTLEKLDDRTVREGERKAAKLHFSQL-----GNSENFLLEVEKSSREKTMKNCVTGES 177

Query: 198 EDKRSNAGFDGRWYTDINATL----SSLESKDHLQAPDTEEHNTK--KLD 241
              + +A  D R   D N  L     + E KD L    T+ + T+  KLD
Sbjct: 178 SASKVSANVDSRIEMDSNKGLFIPFPNREIKDSLSTSATQGNGTRDQKLD 227


>gi|31377705 centrosomal protein 97kDa [Homo sapiens]
          Length = 865

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 45/144 (31%), Positives = 71/144 (49%), Gaps = 5/144 (3%)

Query: 23  LEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIE 82
           L +LS+    + R+  + K    L++L L +N IG +E + +L  LE+LNLA NN++ +E
Sbjct: 60  LIQLSVANNRLVRMMGVAKLTL-LRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAME 118

Query: 83  NLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQL 142
            +  C  L  LDL+ N I ++  +  L   + LK L L GN   S      ++  +L  L
Sbjct: 119 QINSCTALQHLDLSDNNISQIGDLSKL---VSLKTLLLHGNIITSLRMAPAYLPRSLAIL 175

Query: 143 KWLDGKEIEPSERIKALQDYSVIE 166
             L   EI     I  L   + +E
Sbjct: 176 S-LAENEIRDLNEISFLASLTELE 198



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 28/79 (35%), Positives = 43/79 (54%), Gaps = 3/79 (3%)

Query: 45  DLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELS 104
           D+  L L  N I K+EN+ K K+L  L++A N + ++  +     L  L+L  N IG + 
Sbjct: 37  DIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVE 96

Query: 105 SIKNLQHNIHLKELFLMGN 123
            +K L   +HL+ L L GN
Sbjct: 97  GLKEL---VHLEWLNLAGN 112


>gi|4826651 hypothetical protein LOC755 [Homo sapiens]
          Length = 256

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 42/148 (28%), Positives = 69/148 (46%), Gaps = 7/148 (4%)

Query: 64  KLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGN 123
           ++  LE + L++N+I  +E +  C+ L++L L  N I  L+ +  L+    L+ L+L  N
Sbjct: 38  EMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELFYLKGLPRLRVLWLAEN 97

Query: 124 PC--ASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDH----- 176
           PC   S   YR  V+ TLP+L+ LD + +   E  +AL +   I      +   H     
Sbjct: 98  PCCGTSPHRYRMTVLRTLPRLQKLDNQAVTEEELSRALSEGEEITAAPEREGTGHGGPKL 157

Query: 177 CLKRAKLKEEAQRKHQEEDKNEDKRSNA 204
           C   + L   A+      D  E+  S A
Sbjct: 158 CCTLSSLSSAAETGRDPLDSEEEATSGA 185


>gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 family,
           member B [Homo sapiens]
          Length = 251

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 45/163 (27%), Positives = 79/163 (48%), Gaps = 14/163 (8%)

Query: 45  DLKILYLQNNLIGKIENVSKLKKLEYLNLALNNI--------EKIENLEGCEELAKLDLT 96
           +L+ L L N  +  + N+ KL KL+ L L+ N I        EK+ NL        L+L+
Sbjct: 43  NLEFLSLINVGLISVSNLPKLPKLKKLELSENRIFGGLDMLAEKLPNL------THLNLS 96

Query: 97  VNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERI 156
            N + ++S+++ L+    LK L L      + + YRE V   LPQL +LDG + E  E  
Sbjct: 97  GNKLKDISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKLLPQLTYLDGYDREDQEAP 156

Query: 157 KALQDYSVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNED 199
            +  +   ++ +  ++E +          E +   +E+D++ED
Sbjct: 157 DSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDEEDDEDED 199


>gi|50593002 small nuclear ribonucleoprotein polypeptide A' [Homo
           sapiens]
          Length = 255

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 44/159 (27%), Positives = 81/159 (50%), Gaps = 8/159 (5%)

Query: 4   ITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVS 63
           +T +LI + A++ + V     EL L   +I  +E++         +   +N I K++   
Sbjct: 4   LTAELIEQAAQYTNAV--RDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFP 61

Query: 64  KLKKLEYLNLALNNIEKIENLEGCEE----LAKLDLTVNFIGELSSIKNLQHNIHLKELF 119
            L++L+ L +  N I +I   EG ++    L +L LT N + EL  +  L     L  L 
Sbjct: 62  LLRRLKTLLVNNNRICRIG--EGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLS 119

Query: 120 LMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKA 158
           ++ NP  +  HYR +V+  +PQ++ LD ++++  ER +A
Sbjct: 120 ILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQEA 158


>gi|61966709 leucine rich repeat containing 67 [Homo sapiens]
          Length = 228

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 34/113 (30%), Positives = 58/113 (51%), Gaps = 8/113 (7%)

Query: 4   ITEDLIRRNA-------EHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLI 56
           +T DLI RN+       E     +  +  ++   + I+ +E +   C++L +LYL +N I
Sbjct: 4   LTLDLIARNSNLKPRKEETISQCLKKITHINFSDKNIDAIEDLSL-CKNLSVLYLYDNCI 62

Query: 57  GKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNL 109
            +I N++    L +L L  N I  IENL   ++L KL L  N+I  +  ++ L
Sbjct: 63  SQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGL 115



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 32/72 (44%), Positives = 43/72 (59%), Gaps = 1/72 (1%)

Query: 22  SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
           +L  L L+   I ++ +++ +  +L  LYLQNN I  IEN+  LKKLE L L  N I  I
Sbjct: 51  NLSVLYLYDNCISQITNLN-YATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVI 109

Query: 82  ENLEGCEELAKL 93
           E LEG  EL +L
Sbjct: 110 EGLEGLGELREL 121



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 27/76 (35%), Positives = 43/76 (56%), Gaps = 4/76 (5%)

Query: 58  KIENVSK-LKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLK 116
           K E +S+ LKK+ ++N +  NI+ IE+L  C+ L+ L L  N I   S I NL +  +L 
Sbjct: 19  KEETISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCI---SQITNLNYATNLT 75

Query: 117 ELFLMGNPCASFDHYR 132
            L+L  N  +  ++ R
Sbjct: 76  HLYLQNNCISCIENLR 91


>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform 1
            [Homo sapiens]
          Length = 1722

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 35/105 (33%), Positives = 57/105 (54%), Gaps = 3/105 (2%)

Query: 46   LKILYLQNNLIGKIENVSK--LKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGEL 103
            L+ L+L +N I  +E  S   L  L+ + ++ N++ KI  L     L KLD++ N + +L
Sbjct: 1037 LRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDL 1096

Query: 104  -SSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDG 147
             S+IK       L EL L GNP     ++R+ ++  LP L+ L+G
Sbjct: 1097 KSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILNG 1141



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 25/99 (25%), Positives = 52/99 (52%), Gaps = 3/99 (3%)

Query: 44   RDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGEL 103
            ++L+ L L +N +   + +     + YL+ + N++  +E +E C  L  L L  N++ EL
Sbjct: 969  KNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSEL 1028

Query: 104  SSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQL 142
             S++NL   + L+EL L  N  ++ + +  + +  L  +
Sbjct: 1029 PSLENL---VLLRELHLDDNSISTVEAFSSYWLPLLQNI 1064



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 25/78 (32%), Positives = 41/78 (52%), Gaps = 6/78 (7%)

Query: 43  CRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGE 102
           C +L+ L L+   +  + ++S  KKL+Y++   N+IE IE    CE L  L + +    +
Sbjct: 817 CTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE----CENLENLCVVLLNKNQ 872

Query: 103 LSSIKNLQ--HNIHLKEL 118
           L+S+  L    NI   EL
Sbjct: 873 LTSLHGLDGCTNIQCLEL 890



 Score = 29.3 bits (64), Expect = 8.0
 Identities = 33/137 (24%), Positives = 60/137 (43%), Gaps = 10/137 (7%)

Query: 65  LKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL-MGN 123
           +K+ +     L NI+K E  +  +EL K +       ++   K  QH  +++ L L M  
Sbjct: 211 MKQFKVEKKKLENIQKQEQDKMNDELYKEE-------KIWKEKFKQHEEYIRNLHLQMEE 263

Query: 124 PCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKL 183
               F   +E    +L  LK  +   ++   + KA   Y    P I+EQ +    K  + 
Sbjct: 264 ERTRFKDQQEKEKNSL--LKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEW 321

Query: 184 KEEAQRKHQEEDKNEDK 200
           KE+  +  Q+E++N  +
Sbjct: 322 KEKEAKIRQKEEENRKR 338


>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform 2
            [Homo sapiens]
          Length = 1336

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 35/105 (33%), Positives = 57/105 (54%), Gaps = 3/105 (2%)

Query: 46   LKILYLQNNLIGKIENVSK--LKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGEL 103
            L+ L+L +N I  +E  S   L  L+ + ++ N++ KI  L     L KLD++ N + +L
Sbjct: 1037 LRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDL 1096

Query: 104  -SSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDG 147
             S+IK       L EL L GNP     ++R+ ++  LP L+ L+G
Sbjct: 1097 KSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILNG 1141



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 25/99 (25%), Positives = 52/99 (52%), Gaps = 3/99 (3%)

Query: 44   RDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGEL 103
            ++L+ L L +N +   + +     + YL+ + N++  +E +E C  L  L L  N++ EL
Sbjct: 969  KNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSEL 1028

Query: 104  SSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQL 142
             S++NL   + L+EL L  N  ++ + +  + +  L  +
Sbjct: 1029 PSLENL---VLLRELHLDDNSISTVEAFSSYWLPLLQNI 1064



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 25/78 (32%), Positives = 41/78 (52%), Gaps = 6/78 (7%)

Query: 43  CRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGE 102
           C +L+ L L+   +  + ++S  KKL+Y++   N+IE IE    CE L  L + +    +
Sbjct: 817 CTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE----CENLENLCVVLLNKNQ 872

Query: 103 LSSIKNLQ--HNIHLKEL 118
           L+S+  L    NI   EL
Sbjct: 873 LTSLHGLDGCTNIQCLEL 890



 Score = 29.3 bits (64), Expect = 8.0
 Identities = 33/137 (24%), Positives = 60/137 (43%), Gaps = 10/137 (7%)

Query: 65  LKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL-MGN 123
           +K+ +     L NI+K E  +  +EL K +       ++   K  QH  +++ L L M  
Sbjct: 211 MKQFKVEKKKLENIQKQEQDKMNDELYKEE-------KIWKEKFKQHEEYIRNLHLQMEE 263

Query: 124 PCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKL 183
               F   +E    +L  LK  +   ++   + KA   Y    P I+EQ +    K  + 
Sbjct: 264 ERTRFKDQQEKEKNSL--LKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEW 321

Query: 184 KEEAQRKHQEEDKNEDK 200
           KE+  +  Q+E++N  +
Sbjct: 322 KEKEAKIRQKEEENRKR 338


>gi|66472382 nischarin [Homo sapiens]
          Length = 1504

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 40/151 (26%), Positives = 73/151 (48%), Gaps = 13/151 (8%)

Query: 33  IERLEHIDKWCRDLKILYLQNNLIGKIENV-SKLKKLEYLNLALNNIEKIENLEGCEELA 91
           ++ L+H+     +L  L L  N +  +E + +KL  ++ LNLA N +E +  L     L 
Sbjct: 325 VDNLQHL----YNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLV 380

Query: 92  KLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLK---WLDG- 147
            LDL  N I ++  ++++     L+ + L+ NP +    YR  V+A   +      LD  
Sbjct: 381 NLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDYRTKVLAQFGERASEVCLDDT 440

Query: 148 ----KEIEPSERIKALQDYSVIEPQIREQEK 174
               KE++  E +KA+Q    ++ ++   EK
Sbjct: 441 VTTEKELDTVEVLKAIQKAKEVKSKLSNPEK 471



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 37/123 (30%), Positives = 65/123 (52%), Gaps = 8/123 (6%)

Query: 46  LKILYLQNNLIGKI-ENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELS 104
           L  L L +N I +I E+V  + K+E+L+L+ N +  ++NL+    L  LDL+ N   +LS
Sbjct: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYN---KLS 345

Query: 105 SIKNLQHNI-HLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYS 163
           S++ L   + ++K L L GN   S     +  + +L  L   D + IE  E ++++    
Sbjct: 346 SLEGLHTKLGNIKTLNLAGNLLESLSGLHK--LYSLVNLDLRDNR-IEQMEEVRSIGSLP 402

Query: 164 VIE 166
            +E
Sbjct: 403 CLE 405


>gi|239756368 PREDICTED: similar to acidic (leucine-rich) nuclear
           phosphoprotein 32 family, member B [Homo sapiens]
          Length = 272

 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 51/204 (25%), Positives = 86/204 (42%), Gaps = 24/204 (11%)

Query: 45  DLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENL--EGCEELAKLDLTVNFIGE 102
           +L+ L L N  +  I N+ KL KL+   L+ N I    N+  E    L  L+L+   + +
Sbjct: 63  NLEFLRLINVGLISISNLPKLPKLKKFVLSENRIFGGLNMSAEKLPNLTHLNLSGKKLKD 122

Query: 103 LSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDY 162
           +S+++ L+    LK L L      + + Y+E V   LPQL  LD  + E  E   +    
Sbjct: 123 ISTLEPLKKLECLKSLDLFNCEVINLNDYQESVFKLLPQLTCLDTYDPEDQEAPDSDAQV 182

Query: 163 SVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLE 222
             ++ +  ++E +          E +   +EED++ED   +                  +
Sbjct: 183 DGVDKEEEDEEGEDEKDXENEDGEEEELDEEEDEDEDVEGD------------------D 224

Query: 223 SKDHLQAPDTEEHNTKKLDNSEDD 246
            KD +    +EE     LD  EDD
Sbjct: 225 DKDEV----SEEEEEFGLDKDEDD 244


>gi|239750893 PREDICTED: similar to acidic (leucine-rich) nuclear
           phosphoprotein 32 family, member B [Homo sapiens]
          Length = 272

 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 51/204 (25%), Positives = 86/204 (42%), Gaps = 24/204 (11%)

Query: 45  DLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENL--EGCEELAKLDLTVNFIGE 102
           +L+ L L N  +  I N+ KL KL+   L+ N I    N+  E    L  L+L+   + +
Sbjct: 63  NLEFLRLINVGLISISNLPKLPKLKKFVLSENRIFGGLNMSAEKLPNLTHLNLSGKKLKD 122

Query: 103 LSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDY 162
           +S+++ L+    LK L L      + + Y+E V   LPQL  LD  + E  E   +    
Sbjct: 123 ISTLEPLKKLECLKSLDLFNCEVINLNDYQESVFKLLPQLTCLDTYDPEDQEAPDSDAQV 182

Query: 163 SVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLE 222
             ++ +  ++E +          E +   +EED++ED   +                  +
Sbjct: 183 DGVDKEEEDEEGEDEKDXENEDGEEEELDEEEDEDEDVEGD------------------D 224

Query: 223 SKDHLQAPDTEEHNTKKLDNSEDD 246
            KD +    +EE     LD  EDD
Sbjct: 225 DKDEV----SEEEEEFGLDKDEDD 244


>gi|210147569 acidic (leucine-rich) nuclear phosphoprotein 32
           family, member E isoform 2 [Homo sapiens]
          Length = 227

 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 42/193 (21%), Positives = 88/193 (45%), Gaps = 19/193 (9%)

Query: 57  GKIENVSK-LKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHL 115
           G+IE ++   K+LE+L++A   +  +  L    +L K +L                  +L
Sbjct: 32  GEIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKQNLK-----------------NL 74

Query: 116 KELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKD 175
           K L L      + + YRE +   L Q+ +LDG + E +E   + ++      +  E+E++
Sbjct: 75  KSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDEDGDEDDEEEEE 134

Query: 176 HCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEH 235
           +     +  EE + + +EED++ED+  +         +    LS L  K+ +Q  + ++ 
Sbjct: 135 NEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYL-MKEEIQDEEDDDD 193

Query: 236 NTKKLDNSEDDLE 248
             ++ +  E++ E
Sbjct: 194 YVEEGEEEEEEEE 206


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,668,495
Number of Sequences: 37866
Number of extensions: 895594
Number of successful extensions: 5595
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 311
Number of HSP's that attempted gapping in prelim test: 4426
Number of HSP's gapped (non-prelim): 1079
length of query: 466
length of database: 18,247,518
effective HSP length: 106
effective length of query: 360
effective length of database: 14,233,722
effective search space: 5124139920
effective search space used: 5124139920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.