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Search of human proteins with 31317307
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31317307 proprotein convertase subtilisin/kexin type 9
preproprotein [Homo sapiens]
(692 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31317307 proprotein convertase subtilisin/kexin type 9 prepro... 1408 0.0
gi|4506775 membrane-bound transcription factor site-1 protease p... 39 0.021
gi|20336248 proprotein convertase subtilisin/kexin type 7 prepro... 36 0.10
gi|4505579 furin preproprotein [Homo sapiens] 35 0.30
gi|239751049 PREDICTED: similar to ATPase, Ca++ transporting, fa... 34 0.40
gi|20336188 paired basic amino acid cleaving system 4 isoform e ... 33 0.89
gi|20336186 paired basic amino acid cleaving system 4 isoform c ... 33 0.89
gi|27894285 paired basic amino acid cleaving system 4 isoform f ... 33 0.89
gi|20336190 paired basic amino acid cleaving system 4 isoform d ... 33 0.89
gi|20336184 paired basic amino acid cleaving system 4 isoform h ... 33 0.89
gi|20336182 paired basic amino acid cleaving system 4 isoform g ... 33 0.89
gi|4505577 paired basic amino acid cleaving system 4 isoform a p... 33 0.89
gi|20336180 paired basic amino acid cleaving system 4 isoform b ... 33 0.89
gi|20336242 proprotein convertase subtilisin/kexin type 1 prepro... 33 1.2
gi|31083288 delta isoform of regulatory subunit B56, protein pho... 32 2.6
gi|31083280 delta isoform of regulatory subunit B56, protein pho... 32 2.6
gi|5453954 delta isoform of regulatory subunit B56, protein phos... 32 2.6
gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens] 32 2.6
gi|186972143 tripeptidyl peptidase II [Homo sapiens] 31 4.4
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro... 31 4.4
gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo ... 30 7.5
gi|172072600 Fc receptor, IgA, IgM, high affinity isoform 1 [Hom... 30 7.5
gi|117320515 Fc receptor, IgA, IgM, high affinity isoform 1 [Hom... 30 7.5
gi|61743978 stabilin 1 precursor [Homo sapiens] 30 7.5
gi|145701025 multiple EGF-like-domains 8 [Homo sapiens] 30 7.5
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 30 7.5
gi|23397653 phosphatidylinositol glycan anchor biosynthesis, cla... 30 7.5
gi|24308227 zinc finger protein 687 [Homo sapiens] 30 7.5
gi|4502337 alpha-2-glycoprotein 1, zinc [Homo sapiens] 30 9.8
gi|11345450 secretin preproprotein [Homo sapiens] 30 9.8
>gi|31317307 proprotein convertase subtilisin/kexin type 9
preproprotein [Homo sapiens]
Length = 692
Score = 1408 bits (3644), Expect = 0.0
Identities = 692/692 (100%), Positives = 692/692 (100%)
Query: 1 MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGT 60
MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGT
Sbjct: 1 MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGT 60
Query: 61 TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLP 120
TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLP
Sbjct: 61 TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLP 120
Query: 121 GFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLV 180
GFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLV
Sbjct: 121 GFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLV 180
Query: 181 EVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAG 240
EVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAG
Sbjct: 181 EVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAG 240
Query: 241 VAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAA 300
VAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAA
Sbjct: 241 VAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAA 300
Query: 301 CQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVD 360
CQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVD
Sbjct: 301 CQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVD 360
Query: 361 LFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSA 420
LFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSA
Sbjct: 361 LFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSA 420
Query: 421 KDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPD 480
KDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPD
Sbjct: 421 KDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPD 480
Query: 481 EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAP 540
EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAP
Sbjct: 481 EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAP 540
Query: 541 PAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASC 600
PAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASC
Sbjct: 541 PAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASC 600
Query: 601 CHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRD 660
CHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRD
Sbjct: 601 CHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRD 660
Query: 661 VSTTGSTSEGAVTAVAICCRSRHLAQASQELQ 692
VSTTGSTSEGAVTAVAICCRSRHLAQASQELQ
Sbjct: 661 VSTTGSTSEGAVTAVAICCRSRHLAQASQELQ 692
>gi|4506775 membrane-bound transcription factor site-1 protease
preproprotein [Homo sapiens]
Length = 1052
Score = 38.5 bits (88), Expect = 0.021
Identities = 62/259 (23%), Positives = 97/259 (37%), Gaps = 39/259 (15%)
Query: 177 GSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSG 236
G+ V V + DT + H F+NV E R HGT +AGV++
Sbjct: 209 GANVRVAVFDTGLSEKHPH---------FKNVKERTNWTNERTLDDGLGHGTFVAGVIAS 259
Query: 237 --RDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYS 294
G A A + RV S L + +++ + L + +
Sbjct: 260 MRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNY----AILKKIDVLNLSIGGPDFMD 315
Query: 295 RVLNAACQRLARAGVVLVTAAGNFRDDACLY----SPASAPEVITVGATNAQD------- 343
L V++V+A GN D LY +PA +VI VG + +D
Sbjct: 316 HPFVDKVWELTANNVIMVSAIGN---DGPLYGTLNNPADQMDVIGVGGIDFEDNIARFSS 372
Query: 344 QPVTLGTLGTNFGRC---VDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMML 400
+ +T L +GR + + G G C + SGTS A+ VAG +++
Sbjct: 373 RGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCR----ALSGTSVASPVVAGAVTLLV 428
Query: 401 SAEPELTL---AELRQRLI 416
S + L A ++Q LI
Sbjct: 429 STVQKRELVNPASMKQALI 447
>gi|20336248 proprotein convertase subtilisin/kexin type 7
preproprotein [Homo sapiens]
Length = 785
Score = 36.2 bits (82), Expect = 0.10
Identities = 58/232 (25%), Positives = 94/232 (40%), Gaps = 39/232 (16%)
Query: 217 HRQASKCDSHGTHLAGVVSGRD------AGVAKGASMRSLRVLNCQGKGTVSGTLIGLEF 270
H + HGT AG ++ GVA G+ + +RVL+ G ++ ++ + F
Sbjct: 219 HPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLD----GPLTDSMEAVAF 274
Query: 271 IRKSQLVQPV----GP----LVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNF--RD 320
+ Q+ GP V P G + + + G + V A+GN +
Sbjct: 275 NKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHN 334
Query: 321 DACLYSP-ASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFA---PGED-----IIGA 371
D C Y A++ +T+GA + + G + C + A G D I+
Sbjct: 335 DNCNYDGYANSIYTVTIGAVDEE------GRMPFYAEECASMLAVTFSGGDKMLRSIVTT 388
Query: 372 SSDCST---CFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSA 420
D C +GTS AA AG+ A+ML P LT ++ Q +I F+A
Sbjct: 389 DWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDV-QHIIVFTA 439
>gi|4505579 furin preproprotein [Homo sapiens]
Length = 794
Score = 34.7 bits (78), Expect = 0.30
Identities = 60/264 (22%), Positives = 93/264 (35%), Gaps = 15/264 (5%)
Query: 177 GSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDS-HGTHLAGVVS 235
G + V +LD I+ +H ++ G +V ++D R D+ HGT AG V+
Sbjct: 144 GHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVA 203
Query: 236 GR------DAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGP----LVV 285
GVA A + +R+L+ + V +GL GP V
Sbjct: 204 AVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTV 263
Query: 286 LLPLAGGYSRVLNAACQRLARAGVVLVTAAGNF--RDDACLYS--PASAPEVITVGATNA 341
P Q G + V A+GN D+C S + AT
Sbjct: 264 DGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQF 323
Query: 342 QDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLS 401
+ P + E I + C S +GTS +A AGI A+ L
Sbjct: 324 GNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLE 383
Query: 402 AEPELTLAELRQRLIHFSAKDVIN 425
A LT +++ ++ S +N
Sbjct: 384 ANKNLTWRDMQHLVVQTSKPAHLN 407
>gi|239751049 PREDICTED: similar to ATPase, Ca++ transporting, fast
twitch 1 [Homo sapiens]
Length = 879
Score = 34.3 bits (77), Expect = 0.40
Identities = 29/95 (30%), Positives = 35/95 (36%), Gaps = 11/95 (11%)
Query: 556 GHVLTGCSSHWEVEDLGTHKPPV----LRPRGQPNQCVGHREASIHASCCHAPGLECKVK 611
G + GCSS V L + P ++ R Q VGH E P + K
Sbjct: 191 GRGVAGCSSGTGVRALWREEKPGGGRRVKRRNPGRQAVGHTEED-------PPRVGTPWK 243
Query: 612 EHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLG 646
EH P PQE T+ T C A G S G
Sbjct: 244 EHTGPGPQEGSTMEAAHAKTTEECLAYFGVSETTG 278
>gi|20336188 paired basic amino acid cleaving system 4 isoform e
preproprotein [Homo sapiens]
Length = 623
Score = 33.1 bits (74), Expect = 0.89
Identities = 62/271 (22%), Positives = 102/271 (37%), Gaps = 41/271 (15%)
Query: 177 GSLVEVYLLDTSIQSDHREIEGR--------VMVTDFENVPEEDGTRFHRQASKCDSHGT 228
G V V +LD I+ +H ++ V D++ P D AS + HGT
Sbjct: 196 GKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD-------ASNENKHGT 248
Query: 229 HLAGVVSGRD------AGVAKGASMRSLRVLNCQGKGTVSGTLIGL-----EFIRKSQLV 277
AG V+ G+A A + +R+L+ V +G+ + S
Sbjct: 249 RCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGP 308
Query: 278 QPVGPLVVLLPLAGGYSRVLNAACQ---RLARAGV--VLVTAAGNF-RDDACLYSPASAP 331
G V G R+ A + + R G+ + V A+GN R+
Sbjct: 309 DDDGKTV------DGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTN 362
Query: 332 EVITVGATNAQD---QPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQA 388
+ T+ ++A + +P L + A E I + C +GTS +
Sbjct: 363 SIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVS 422
Query: 389 AAHVAGIAAMMLSAEPELTLAELRQRLIHFS 419
A VAGI A+ L A +LT +++ L+ S
Sbjct: 423 APMVAGIIALALEANSQLTWRDVQHLLVKTS 453
>gi|20336186 paired basic amino acid cleaving system 4 isoform c
preproprotein [Homo sapiens]
Length = 487
Score = 33.1 bits (74), Expect = 0.89
Identities = 62/271 (22%), Positives = 102/271 (37%), Gaps = 41/271 (15%)
Query: 177 GSLVEVYLLDTSIQSDHREIEGR--------VMVTDFENVPEEDGTRFHRQASKCDSHGT 228
G V V +LD I+ +H ++ V D++ P D AS + HGT
Sbjct: 196 GKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD-------ASNENKHGT 248
Query: 229 HLAGVVSGRD------AGVAKGASMRSLRVLNCQGKGTVSGTLIGL-----EFIRKSQLV 277
AG V+ G+A A + +R+L+ V +G+ + S
Sbjct: 249 RCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGP 308
Query: 278 QPVGPLVVLLPLAGGYSRVLNAACQ---RLARAGV--VLVTAAGNF-RDDACLYSPASAP 331
G V G R+ A + + R G+ + V A+GN R+
Sbjct: 309 DDDGKTV------DGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTN 362
Query: 332 EVITVGATNAQD---QPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQA 388
+ T+ ++A + +P L + A E I + C +GTS +
Sbjct: 363 SIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVS 422
Query: 389 AAHVAGIAAMMLSAEPELTLAELRQRLIHFS 419
A VAGI A+ L A +LT +++ L+ S
Sbjct: 423 APMVAGIIALALEANSQLTWRDVQHLLVKTS 453
>gi|27894285 paired basic amino acid cleaving system 4 isoform f
preproprotein [Homo sapiens]
Length = 664
Score = 33.1 bits (74), Expect = 0.89
Identities = 62/271 (22%), Positives = 102/271 (37%), Gaps = 41/271 (15%)
Query: 177 GSLVEVYLLDTSIQSDHREIEGR--------VMVTDFENVPEEDGTRFHRQASKCDSHGT 228
G V V +LD I+ +H ++ V D++ P D AS + HGT
Sbjct: 196 GKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD-------ASNENKHGT 248
Query: 229 HLAGVVSGRD------AGVAKGASMRSLRVLNCQGKGTVSGTLIGL-----EFIRKSQLV 277
AG V+ G+A A + +R+L+ V +G+ + S
Sbjct: 249 RCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGP 308
Query: 278 QPVGPLVVLLPLAGGYSRVLNAACQ---RLARAGV--VLVTAAGNF-RDDACLYSPASAP 331
G V G R+ A + + R G+ + V A+GN R+
Sbjct: 309 DDDGKTV------DGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTN 362
Query: 332 EVITVGATNAQD---QPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQA 388
+ T+ ++A + +P L + A E I + C +GTS +
Sbjct: 363 SIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVS 422
Query: 389 AAHVAGIAAMMLSAEPELTLAELRQRLIHFS 419
A VAGI A+ L A +LT +++ L+ S
Sbjct: 423 APMVAGIIALALEANSQLTWRDVQHLLVKTS 453
>gi|20336190 paired basic amino acid cleaving system 4 isoform d
preproprotein [Homo sapiens]
Length = 652
Score = 33.1 bits (74), Expect = 0.89
Identities = 62/271 (22%), Positives = 102/271 (37%), Gaps = 41/271 (15%)
Query: 177 GSLVEVYLLDTSIQSDHREIEGR--------VMVTDFENVPEEDGTRFHRQASKCDSHGT 228
G V V +LD I+ +H ++ V D++ P D AS + HGT
Sbjct: 196 GKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD-------ASNENKHGT 248
Query: 229 HLAGVVSGRD------AGVAKGASMRSLRVLNCQGKGTVSGTLIGL-----EFIRKSQLV 277
AG V+ G+A A + +R+L+ V +G+ + S
Sbjct: 249 RCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGP 308
Query: 278 QPVGPLVVLLPLAGGYSRVLNAACQ---RLARAGV--VLVTAAGNF-RDDACLYSPASAP 331
G V G R+ A + + R G+ + V A+GN R+
Sbjct: 309 DDDGKTV------DGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTN 362
Query: 332 EVITVGATNAQD---QPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQA 388
+ T+ ++A + +P L + A E I + C +GTS +
Sbjct: 363 SIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVS 422
Query: 389 AAHVAGIAAMMLSAEPELTLAELRQRLIHFS 419
A VAGI A+ L A +LT +++ L+ S
Sbjct: 423 APMVAGIIALALEANSQLTWRDVQHLLVKTS 453
>gi|20336184 paired basic amino acid cleaving system 4 isoform h
preproprotein [Homo sapiens]
Length = 962
Score = 33.1 bits (74), Expect = 0.89
Identities = 62/271 (22%), Positives = 102/271 (37%), Gaps = 41/271 (15%)
Query: 177 GSLVEVYLLDTSIQSDHREIEGR--------VMVTDFENVPEEDGTRFHRQASKCDSHGT 228
G V V +LD I+ +H ++ V D++ P D AS + HGT
Sbjct: 196 GKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD-------ASNENKHGT 248
Query: 229 HLAGVVSGRD------AGVAKGASMRSLRVLNCQGKGTVSGTLIGL-----EFIRKSQLV 277
AG V+ G+A A + +R+L+ V +G+ + S
Sbjct: 249 RCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGP 308
Query: 278 QPVGPLVVLLPLAGGYSRVLNAACQ---RLARAGV--VLVTAAGNF-RDDACLYSPASAP 331
G V G R+ A + + R G+ + V A+GN R+
Sbjct: 309 DDDGKTV------DGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTN 362
Query: 332 EVITVGATNAQD---QPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQA 388
+ T+ ++A + +P L + A E I + C +GTS +
Sbjct: 363 SIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVS 422
Query: 389 AAHVAGIAAMMLSAEPELTLAELRQRLIHFS 419
A VAGI A+ L A +LT +++ L+ S
Sbjct: 423 APMVAGIIALALEANSQLTWRDVQHLLVKTS 453
>gi|20336182 paired basic amino acid cleaving system 4 isoform g
preproprotein [Homo sapiens]
Length = 975
Score = 33.1 bits (74), Expect = 0.89
Identities = 62/271 (22%), Positives = 102/271 (37%), Gaps = 41/271 (15%)
Query: 177 GSLVEVYLLDTSIQSDHREIEGR--------VMVTDFENVPEEDGTRFHRQASKCDSHGT 228
G V V +LD I+ +H ++ V D++ P D AS + HGT
Sbjct: 196 GKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD-------ASNENKHGT 248
Query: 229 HLAGVVSGRD------AGVAKGASMRSLRVLNCQGKGTVSGTLIGL-----EFIRKSQLV 277
AG V+ G+A A + +R+L+ V +G+ + S
Sbjct: 249 RCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGP 308
Query: 278 QPVGPLVVLLPLAGGYSRVLNAACQ---RLARAGV--VLVTAAGNF-RDDACLYSPASAP 331
G V G R+ A + + R G+ + V A+GN R+
Sbjct: 309 DDDGKTV------DGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTN 362
Query: 332 EVITVGATNAQD---QPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQA 388
+ T+ ++A + +P L + A E I + C +GTS +
Sbjct: 363 SIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVS 422
Query: 389 AAHVAGIAAMMLSAEPELTLAELRQRLIHFS 419
A VAGI A+ L A +LT +++ L+ S
Sbjct: 423 APMVAGIIALALEANSQLTWRDVQHLLVKTS 453
>gi|4505577 paired basic amino acid cleaving system 4 isoform a
preproprotein [Homo sapiens]
Length = 969
Score = 33.1 bits (74), Expect = 0.89
Identities = 62/271 (22%), Positives = 102/271 (37%), Gaps = 41/271 (15%)
Query: 177 GSLVEVYLLDTSIQSDHREIEGR--------VMVTDFENVPEEDGTRFHRQASKCDSHGT 228
G V V +LD I+ +H ++ V D++ P D AS + HGT
Sbjct: 196 GKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD-------ASNENKHGT 248
Query: 229 HLAGVVSGRD------AGVAKGASMRSLRVLNCQGKGTVSGTLIGL-----EFIRKSQLV 277
AG V+ G+A A + +R+L+ V +G+ + S
Sbjct: 249 RCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGP 308
Query: 278 QPVGPLVVLLPLAGGYSRVLNAACQ---RLARAGV--VLVTAAGNF-RDDACLYSPASAP 331
G V G R+ A + + R G+ + V A+GN R+
Sbjct: 309 DDDGKTV------DGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTN 362
Query: 332 EVITVGATNAQD---QPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQA 388
+ T+ ++A + +P L + A E I + C +GTS +
Sbjct: 363 SIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVS 422
Query: 389 AAHVAGIAAMMLSAEPELTLAELRQRLIHFS 419
A VAGI A+ L A +LT +++ L+ S
Sbjct: 423 APMVAGIIALALEANSQLTWRDVQHLLVKTS 453
>gi|20336180 paired basic amino acid cleaving system 4 isoform b
preproprotein [Homo sapiens]
Length = 956
Score = 33.1 bits (74), Expect = 0.89
Identities = 62/271 (22%), Positives = 102/271 (37%), Gaps = 41/271 (15%)
Query: 177 GSLVEVYLLDTSIQSDHREIEGR--------VMVTDFENVPEEDGTRFHRQASKCDSHGT 228
G V V +LD I+ +H ++ V D++ P D AS + HGT
Sbjct: 196 GKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYD-------ASNENKHGT 248
Query: 229 HLAGVVSGRD------AGVAKGASMRSLRVLNCQGKGTVSGTLIGL-----EFIRKSQLV 277
AG V+ G+A A + +R+L+ V +G+ + S
Sbjct: 249 RCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGP 308
Query: 278 QPVGPLVVLLPLAGGYSRVLNAACQ---RLARAGV--VLVTAAGNF-RDDACLYSPASAP 331
G V G R+ A + + R G+ + V A+GN R+
Sbjct: 309 DDDGKTV------DGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTN 362
Query: 332 EVITVGATNAQD---QPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQA 388
+ T+ ++A + +P L + A E I + C +GTS +
Sbjct: 363 SIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVS 422
Query: 389 AAHVAGIAAMMLSAEPELTLAELRQRLIHFS 419
A VAGI A+ L A +LT +++ L+ S
Sbjct: 423 APMVAGIIALALEANSQLTWRDVQHLLVKTS 453
>gi|20336242 proprotein convertase subtilisin/kexin type 1
preproprotein [Homo sapiens]
Length = 753
Score = 32.7 bits (73), Expect = 1.2
Identities = 18/53 (33%), Positives = 28/53 (52%), Gaps = 2/53 (3%)
Query: 378 CFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVI--NEAW 428
C + +GTS +A AGI A+ L A P LT +++ ++ S D + N W
Sbjct: 374 CTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGW 426
>gi|31083288 delta isoform of regulatory subunit B56, protein
phosphatase 2A isoform 3 [Homo sapiens]
Length = 496
Score = 31.6 bits (70), Expect = 2.6
Identities = 16/45 (35%), Positives = 27/45 (60%), Gaps = 2/45 (4%)
Query: 408 LAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAG 452
L E+ + + H ++DV+ EA +PE + + NL LPPS++ G
Sbjct: 43 LNEMVEYITH--SRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTG 85
>gi|31083280 delta isoform of regulatory subunit B56, protein
phosphatase 2A isoform 2 [Homo sapiens]
Length = 570
Score = 31.6 bits (70), Expect = 2.6
Identities = 16/45 (35%), Positives = 27/45 (60%), Gaps = 2/45 (4%)
Query: 408 LAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAG 452
L E+ + + H ++DV+ EA +PE + + NL LPPS++ G
Sbjct: 117 LNEMVEYITH--SRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTG 159
>gi|5453954 delta isoform of regulatory subunit B56, protein
phosphatase 2A isoform 1 [Homo sapiens]
Length = 602
Score = 31.6 bits (70), Expect = 2.6
Identities = 16/45 (35%), Positives = 27/45 (60%), Gaps = 2/45 (4%)
Query: 408 LAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAG 452
L E+ + + H ++DV+ EA +PE + + NL LPPS++ G
Sbjct: 149 LNEMVEYITH--SRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTG 191
>gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]
Length = 2303
Score = 31.6 bits (70), Expect = 2.6
Identities = 43/187 (22%), Positives = 67/187 (35%), Gaps = 31/187 (16%)
Query: 426 EAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDEELLS 485
+AW P D P +AA P S Q +A GP +++RC+ L S
Sbjct: 1028 QAWLPADHLSKVPEKLAAAPLSVASKALQKL-----AAQEGP----LSLSRCS---SLSS 1075
Query: 486 CSSFSRSGKRRGERME---------AQGGKLVCRAHNAFGGEGVYAIARCCLLPQAN--- 533
SS R G G ++ + G + + G ++ P+ N
Sbjct: 1076 LSSAGRPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGR 1135
Query: 534 -CSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHR 592
V A P+ +S + + VL+ CSS V LG+ + P + C G
Sbjct: 1136 GLGVEDATPSSSSEN---YVQETPLVLSRCSS---VSSLGSFESPSIASSIPSEPCSGQG 1189
Query: 593 EASIHAS 599
+I S
Sbjct: 1190 SGTISPS 1196
>gi|186972143 tripeptidyl peptidase II [Homo sapiens]
Length = 1249
Score = 30.8 bits (68), Expect = 4.4
Identities = 49/207 (23%), Positives = 83/207 (40%), Gaps = 35/207 (16%)
Query: 225 SHGTHLAGVVSG------RDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFI----RKS 274
+HGTH+A + +G GVA GA + S+++ + + +GT + I K
Sbjct: 263 AHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMIEVINHKC 322
Query: 275 QLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYS----PASA 330
LV P +G V+N A + + ++ V++AGN + CL + +
Sbjct: 323 DLVNYSYGEATHWPNSGRICEVINEA---VWKHNIIYVSSAGN--NGPCLSTVGCPGGTT 377
Query: 331 PEVITVGATNAQDQPVTLGTL----------------GTNFGRCVDLFAPGEDIIGASSD 374
VI VGA + D V +L + V + APG I +
Sbjct: 378 SSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNW 437
Query: 375 CSTCFVSQSGTSQAAAHVAGIAAMMLS 401
+GTS ++ + G A++LS
Sbjct: 438 TLRGTQLMNGTSMSSPNACGGIALILS 464
>gi|20336246 proprotein convertase subtilisin/kexin type 5
preproprotein [Homo sapiens]
Length = 913
Score = 30.8 bits (68), Expect = 4.4
Identities = 16/48 (33%), Positives = 26/48 (54%)
Query: 378 CFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVIN 425
C + +GTS +A AGI A+ L A P LT +++ ++ S +N
Sbjct: 378 CTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLN 425
>gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo
sapiens]
Length = 638
Score = 30.0 bits (66), Expect = 7.5
Identities = 15/49 (30%), Positives = 27/49 (55%)
Query: 378 CFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINE 426
C + SGTS AA AG+ A+ L A LT +++ + S ++ +++
Sbjct: 376 CTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHD 424
>gi|172072600 Fc receptor, IgA, IgM, high affinity isoform 1 [Homo
sapiens]
Length = 265
Score = 30.0 bits (66), Expect = 7.5
Identities = 14/29 (48%), Positives = 20/29 (68%)
Query: 4 VSSRRSWWPLPLLLLLLLLLGPAGARAQE 32
V+SRR+ W +PL L+L LL G + A Q+
Sbjct: 37 VTSRRAGWKMPLFLILCLLQGSSFALPQK 65
>gi|117320515 Fc receptor, IgA, IgM, high affinity isoform 1 [Homo
sapiens]
Length = 265
Score = 30.0 bits (66), Expect = 7.5
Identities = 14/29 (48%), Positives = 20/29 (68%)
Query: 4 VSSRRSWWPLPLLLLLLLLLGPAGARAQE 32
V+SRR+ W +PL L+L LL G + A Q+
Sbjct: 37 VTSRRAGWKMPLFLILCLLQGSSFALPQK 65
>gi|61743978 stabilin 1 precursor [Homo sapiens]
Length = 2570
Score = 30.0 bits (66), Expect = 7.5
Identities = 39/164 (23%), Positives = 55/164 (33%), Gaps = 16/164 (9%)
Query: 530 PQANC-----SVHTAPPAEASMGTRVHCHQQ---GHVLTGCSSHWEVEDLGTHKPPVLRP 581
P ANC T A G + C + H GCS H T P R
Sbjct: 1426 PNANCVQDSAGASTCACAAGYSGNGIFCSEVDPCAHGHGGCSPHANC----TKVAPGQRT 1481
Query: 582 RGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTG---CSAL 638
+ +G E + C C + IP +QV+ +C EG++ G C L
Sbjct: 1482 CTCQDGYMGDGELCQEINSCLIHHGGCHIHAECIPTGPQQVSCSCREGYSGDGIRTCELL 1541
Query: 639 PGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEGAVTAVAICCRSR 682
S G + TC + D T + + CR+R
Sbjct: 1542 DPCSKNNGGCSPYATC-KSTGDGQRTCTCDTAHTVGDGLTCRAR 1584
>gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]
Length = 2778
Score = 30.0 bits (66), Expect = 7.5
Identities = 45/165 (27%), Positives = 60/165 (36%), Gaps = 29/165 (17%)
Query: 516 GGEGVYAIAR--CCLLPQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGT 573
GG G A+ R LP C + ++P A G CH G L+G +H LG
Sbjct: 1790 GGFGGVALGRLLALTLPPDPCRLLSSPEACNQSGACTWCH--GACLSGDQAH----RLGC 1843
Query: 574 HKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGI--PAPQEQVTVACEEGWT 631
P P +C R S EC + P E T C+ W
Sbjct: 1844 GGSPCSPMPRSPEECRRLRTCS-----------ECLARHPRTLQPGDGEASTPRCK--WC 1890
Query: 632 LTGC--SALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEGAVTA 674
T C A G + G+ +N C + R+V G+ SE A A
Sbjct: 1891 -TNCPEGACIGRN---GSCTSENDCRINQREVFWAGNCSEAACGA 1931
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 30.0 bits (66), Expect = 7.5
Identities = 15/28 (53%), Positives = 18/28 (64%)
Query: 27 GARAQEDEDGDYEELVLALRSEEDGLAE 54
G A E+EDG EE L SE+DGL+E
Sbjct: 575 GGSAAEEEDGAEEESTLKDSSEKDGLSE 602
>gi|23397653 phosphatidylinositol glycan anchor biosynthesis,
class T precursor [Homo sapiens]
Length = 578
Score = 30.0 bits (66), Expect = 7.5
Identities = 17/32 (53%), Positives = 21/32 (65%), Gaps = 1/32 (3%)
Query: 13 LPLLLLLLLLLGPAG-ARAQEDEDGDYEELVL 43
+PL LL+LLLLGP G A+ D EELV+
Sbjct: 5 MPLALLVLLLLGPGGWCLAEPPRDSLREELVI 36
>gi|24308227 zinc finger protein 687 [Homo sapiens]
Length = 1237
Score = 30.0 bits (66), Expect = 7.5
Identities = 22/66 (33%), Positives = 29/66 (43%), Gaps = 8/66 (12%)
Query: 583 GQPNQCVGHR-EASIHASCCHAPGLECKVKEHGIPAPQEQV-------TVACEEGWTLTG 634
G+P VG E + AS PG+ + +HG+P P V TV E+ L G
Sbjct: 41 GKPEPGVGSESEDTAAASAGDGPGVPAQASDHGLPPPDISVVSVIVKNTVCPEQSEALAG 100
Query: 635 CSALPG 640
SA G
Sbjct: 101 GSAGDG 106
>gi|4502337 alpha-2-glycoprotein 1, zinc [Homo sapiens]
Length = 298
Score = 29.6 bits (65), Expect = 9.8
Identities = 16/26 (61%), Positives = 20/26 (76%), Gaps = 2/26 (7%)
Query: 13 LPLLLLLLLLLGPAGARAQEDEDGDY 38
+P+LL LLLLLGP A QE++DG Y
Sbjct: 5 VPVLLSLLLLLGP--AVPQENQDGRY 28
>gi|11345450 secretin preproprotein [Homo sapiens]
Length = 121
Score = 29.6 bits (65), Expect = 9.8
Identities = 19/39 (48%), Positives = 22/39 (56%), Gaps = 4/39 (10%)
Query: 12 PLPLLLLLLLLLG----PAGARAQEDEDGDYEELVLALR 46
P PLLLLLLLL G PA RA+ DG + + LR
Sbjct: 3 PRPLLLLLLLLGGSAARPAPPRARRHSDGTFTSELSRLR 41
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,102,433
Number of Sequences: 37866
Number of extensions: 1412768
Number of successful extensions: 3700
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 3671
Number of HSP's gapped (non-prelim): 40
length of query: 692
length of database: 18,247,518
effective HSP length: 109
effective length of query: 583
effective length of database: 14,120,124
effective search space: 8232032292
effective search space used: 8232032292
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.