Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 31317290
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2
[Homo sapiens]
(731 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 1517 0.0
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 1503 0.0
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 1160 0.0
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 472 e-133
gi|222352183 neural precursor cell expressed, developmentally do... 462 e-130
gi|21361472 neural precursor cell expressed, developmentally dow... 462 e-130
gi|222352094 neural precursor cell expressed, developmentally do... 462 e-130
gi|222352092 neural precursor cell expressed, developmentally do... 462 e-130
gi|222352090 neural precursor cell expressed, developmentally do... 462 e-130
gi|222352088 neural precursor cell expressed, developmentally do... 462 e-130
gi|222352086 neural precursor cell expressed, developmentally do... 462 e-130
gi|222352084 neural precursor cell expressed, developmentally do... 462 e-130
gi|222352082 neural precursor cell expressed, developmentally do... 462 e-130
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 452 e-127
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 450 e-126
gi|114520609 neural precursor cell expressed, developmentally do... 449 e-126
gi|114520607 neural precursor cell expressed, developmentally do... 449 e-126
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 430 e-120
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 360 2e-99
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 360 2e-99
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 330 3e-90
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 272 9e-73
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 197 2e-50
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 197 2e-50
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 197 2e-50
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 192 9e-49
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 187 2e-47
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 176 5e-44
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 176 7e-44
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 176 7e-44
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 1517 bits (3927), Expect = 0.0
Identities = 731/731 (100%), Positives = 731/731 (100%)
Query: 1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP 60
MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
Sbjct: 1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP 60
Query: 61 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK 120
KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
Sbjct: 61 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK 120
Query: 121 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA 180
LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
Sbjct: 121 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA 180
Query: 181 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY 240
PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
Sbjct: 181 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY 240
Query: 241 EQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVD 300
EQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVD
Sbjct: 241 EQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVD 300
Query: 301 HNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLR 360
HNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLR
Sbjct: 301 HNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLR 360
Query: 361 HELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVARE 420
HELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVARE
Sbjct: 361 HELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVARE 420
Query: 421 WLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYI 480
WLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYI
Sbjct: 421 WLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYI 480
Query: 481 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 540
NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL
Sbjct: 481 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 540
Query: 541 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 600
QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK
Sbjct: 541 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 600
Query: 601 ELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTR 660
ELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTR
Sbjct: 601 ELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTR 660
Query: 661 VPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLT 720
VPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLT
Sbjct: 661 VPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLT 720
Query: 721 AVEETCGFAVE 731
AVEETCGFAVE
Sbjct: 721 AVEETCGFAVE 731
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 1503 bits (3890), Expect = 0.0
Identities = 731/757 (96%), Positives = 731/757 (96%), Gaps = 26/757 (3%)
Query: 1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP 60
MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
Sbjct: 1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP 60
Query: 61 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK 120
KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
Sbjct: 61 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK 120
Query: 121 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA 180
LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
Sbjct: 121 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA 180
Query: 181 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY 240
PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
Sbjct: 181 PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY 240
Query: 241 EQRTTVQGQVYFLHTQTGVSTWHDPRIP--------------------------RDLNSV 274
EQRTTVQGQVYFLHTQTGVSTWHDPRIP RDLNSV
Sbjct: 241 EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV 300
Query: 275 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS 334
NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
Sbjct: 301 NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS 360
Query: 335 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR 394
EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
Sbjct: 361 EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR 420
Query: 395 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS 454
PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
Sbjct: 421 PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS 480
Query: 455 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV 514
INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
Sbjct: 481 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV 540
Query: 515 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI 574
WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
Sbjct: 541 WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI 600
Query: 575 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR 634
EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
Sbjct: 601 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR 660
Query: 635 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP 694
WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
Sbjct: 661 WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP 720
Query: 695 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 731
KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
Sbjct: 721 KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 757
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 1160 bits (3002), Expect = 0.0
Identities = 573/766 (74%), Positives = 636/766 (83%), Gaps = 53/766 (6%)
Query: 1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP 60
MSNPG RRNG +K+RLTVLCAKNL KKDFFRLPDPFAK+VVDGSGQCHSTDTVKNTLDP
Sbjct: 1 MSNPGGRRNGP-VKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDP 59
Query: 61 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK 120
KWNQHYDLY+GK+DS+TISVWNHKKIHKKQGAGFLGCVRLLSNAI+RLKDTGYQRLDLCK
Sbjct: 60 KWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCK 119
Query: 121 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENE------------GTVY----- 163
L P+D D VRGQIVVSLQ+RDRIGTGG VVDC L +N+ G +
Sbjct: 120 LGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHI 179
Query: 164 --------------EDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQA 209
E S PGRPLSCF++E P + + GA G S D RL
Sbjct: 180 TRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCG---------QSSDPRLAE 230
Query: 210 QRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPR 269
+R+R+ R + +R H H P+LPEGYEQRTT QGQVYFLHTQTGVSTWHDPR+PR
Sbjct: 231 RRVRSQRHRNYM----SRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPR 286
Query: 270 DLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPR----LHHIMNHQCQLKE 325
DL+++NC+ELGPLPPGWE+R+T +GR+YFVDHNNRTTQFTDPR LH ++N Q QLK+
Sbjct: 287 DLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKD 346
Query: 326 PSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEE 385
Q + S + E L RY+RDLVQKLK+LR ELS QQPQAGHCRIEVSREEIFEE
Sbjct: 347 QQQQ-QVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEE 405
Query: 386 SYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIY 445
SYRQ+MKMRPKDL KRLM+KFRGEEGLDYGGVAREWLYLL HEMLNPYYGLFQYS D+IY
Sbjct: 406 SYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIY 465
Query: 446 MLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESV 505
LQINPDS++NP+HLSYFHFVGRIMG+AVFHGHYI+GGFT+PFYKQLLGK I L D+E V
Sbjct: 466 TLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELV 525
Query: 506 DPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLY 565
DP+LH SLVWILENDIT VLDHTFCVEHNA+G I+QHELKPNG+++PV EENKKEYVRLY
Sbjct: 526 DPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLY 585
Query: 566 VNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH 625
VNWRF+RGIEAQFLALQKGFNE+IPQHLLK FD+KELELII GL KID+NDWK NTRLKH
Sbjct: 586 VNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH 645
Query: 626 CVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHL 685
C DSNIV+WFW+AVE FDEERRARLLQFVTGS+RVPLQGFKALQ GAAGPRLFTIH
Sbjct: 646 CTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQ---GAAGPRLFTIHQ 702
Query: 686 IDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 731
IDA T+NLPKAHTCFNRIDIPPYESYEKLYEKLLTA+EETCGFAVE
Sbjct: 703 IDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 748
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 472 bits (1215), Expect = e-133
Identities = 246/520 (47%), Positives = 329/520 (63%), Gaps = 40/520 (7%)
Query: 214 NPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNS 273
N D+ + Q+ + P G LP G+E+RT G+VYF++ T ++ W DPR LN
Sbjct: 381 NQDLFATSQSKEFDPLG----PLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNE 436
Query: 274 VNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLP 333
PLP GWE+R TV G YFVDHN RTT + DPR
Sbjct: 437 ------KPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPR--------------------- 469
Query: 334 SEGSLEDEELPAQRYERDLVQKLKVLRHEL-SLQQPQAGHCRIEVSREEIFEESYRQIMK 392
G + P Y RD K++ R L PQ H +I V+R+ +FE+S++QIM
Sbjct: 470 -TGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQ--HIKITVTRKTLFEDSFQQIMS 526
Query: 393 MRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPD 452
P+DL++RL V F GEEGLDYGGVAREW +LL HE+LNP Y LF+Y+ + Y LQINP
Sbjct: 527 FSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPA 586
Query: 453 SSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKS 512
S INPDHL YF F+GR + +A+FHG +I+ GF++PFYK++L KP+ L DLES+DPE + S
Sbjct: 587 SYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNS 646
Query: 513 LVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFM 571
L+W+ EN+I L+ F V+ G I H+LKPNG N+ VTEENK+EY+R+ WR
Sbjct: 647 LIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLS 706
Query: 572 RGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSN 631
RG+E Q A +GFNE++PQ L+ FD KELE+++ G+ +IDLNDW+ + +H S
Sbjct: 707 RGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSK 766
Query: 632 IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTD 691
+ WFWQ V+ D E+R RLLQFVTG+ R+P+ GF L GS GP+ F I + +
Sbjct: 767 QIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN---GPQKFCIEKV-GKEN 822
Query: 692 NLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 731
LP++HTCFNR+D+PPY+SYE+L EKLL A+EET GF E
Sbjct: 823 WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 862
Score = 70.5 bits (171), Expect = 5e-12
Identities = 71/307 (23%), Positives = 111/307 (36%), Gaps = 18/307 (5%)
Query: 14 KIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKT 73
++++TV+ AK K + P P+ ++ VDG Q T+ NT PKW Q + V
Sbjct: 19 QLQITVISAKLKENKKNWFGPSPYVEVTVDG--QSKKTEKCNNTNSPKWKQPLTVIVTPV 76
Query: 74 DSITISVWNHKKIHKK--QGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRG 131
+ VW+H+ + G L L + +L++ P++T
Sbjct: 77 SKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLS 136
Query: 132 QIVVSLQTRDRIGTGGSVVDCRGLLENEG-------TVYEDSGPGRPLSCFMEEPAPYTD 184
+ LQ + T G +N+ T +G P E +
Sbjct: 137 ICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSG 196
Query: 185 STGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRT 244
+ + G + P + R V GS + + G + LP
Sbjct: 197 NNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGS-PSATSESDGSSTGSLPPTNTNTN 255
Query: 245 TVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNR 304
T +G L +S PR LN V PLPPGWE R GR+Y+VDH +
Sbjct: 256 TSEGATSGLIIPLTISGGSG---PRPLNPVT---QAPLPPGWEQRVDQHGRVYYVDHVEK 309
Query: 305 TTQFTDP 311
T + P
Sbjct: 310 RTTWDRP 316
Score = 63.5 bits (153), Expect = 7e-10
Identities = 35/89 (39%), Positives = 46/89 (51%), Gaps = 15/89 (16%)
Query: 232 QSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRST 291
Q+P LP G+EQR G+VY++ +TW P PLPPGWE R
Sbjct: 284 QAP-LPPGWEQRVDQHGRVYYVDHVEKRTTWDRPE--------------PLPPGWERRVD 328
Query: 292 VSGRIYFVDHNNRTTQFTDPRLHHIMNHQ 320
GRIY+VDH RTT + P L + N++
Sbjct: 329 NMGRIYYVDHFTRTTTWQRPTLESVRNYE 357
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 462 bits (1188), Expect = e-130
Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410
Query: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323
R S+N ++LGPLPPGWE R + GR +++DHN++ TQ+ DPRL +
Sbjct: 411 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 462
Query: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383
P+ PA Y R+ QK R +L +++ R IF
Sbjct: 463 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 507
Query: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442
EESYR+IM + RP LK RL ++F E+GLDYGGVAREW +LL EM NPYYGLF+YS
Sbjct: 508 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 567
Query: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501
+ Y LQINP+S + N DHLSYF F+GR+ GLAVFHG ++G F PFYK +LGK I L+D
Sbjct: 568 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 627
Query: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561
+ESVD E + SL WILEND T LD FC++ FG+ Q +LKPNG + VT ENK+EY
Sbjct: 628 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 686
Query: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621
+ L + WRF+ ++ Q A +GF EL+P L+K FD+ ELEL++ GL +D+NDW+ ++
Sbjct: 687 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 746
Query: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680
K+ ++ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+L
Sbjct: 747 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 803
Query: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728
FTI + + LP+AHTCFNR+D+PPYE++E L EKLL AVE GF
Sbjct: 804 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 50.4 bits (119), Expect = 6e-06
Identities = 46/172 (26%), Positives = 69/172 (40%), Gaps = 55/172 (31%)
Query: 205 QRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQG------QVYFLHTQTG 258
QR + RLR+ V ++ + P P P G + +TV G V ++HT G
Sbjct: 210 QREPSSRLRSCSVTDAVAEQGHLP----PPSAPAGRARSSTVTGGEEPTPSVAYVHTTPG 265
Query: 259 VSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----- 313
LP GWE R GR Y+V+HNNRTT +T P +
Sbjct: 266 -----------------------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 302
Query: 314 ----------HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 351
+H++ Q + L P+ L P EG+ ++ P +R +D
Sbjct: 303 GASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 351
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 30.4 bits (67), Expect = 6.1
Identities = 10/34 (29%), Positives = 19/34 (55%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267
P LP G+E++ G+ Y+++ + WH P +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 462 bits (1188), Expect = e-130
Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 452 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 511
Query: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323
R S+N ++LGPLPPGWE R + GR +++DHN++ TQ+ DPRL +
Sbjct: 512 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 563
Query: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383
P+ PA Y R+ QK R +L +++ R IF
Sbjct: 564 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 608
Query: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442
EESYR+IM + RP LK RL ++F E+GLDYGGVAREW +LL EM NPYYGLF+YS
Sbjct: 609 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 668
Query: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501
+ Y LQINP+S + N DHLSYF F+GR+ GLAVFHG ++G F PFYK +LGK I L+D
Sbjct: 669 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 728
Query: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561
+ESVD E + SL WILEND T LD FC++ FG+ Q +LKPNG + VT ENK+EY
Sbjct: 729 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 787
Query: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621
+ L + WRF+ ++ Q A +GF EL+P L+K FD+ ELEL++ GL +D+NDW+ ++
Sbjct: 788 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 847
Query: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680
K+ ++ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+L
Sbjct: 848 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 904
Query: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728
FTI + + LP+AHTCFNR+D+PPYE++E L EKLL AVE GF
Sbjct: 905 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 226
Score = 46.6 bits (109), Expect = 8e-05
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%)
Query: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 322
LP GWE R GR Y+V+HNNRTT +T P + +H++ Q +
Sbjct: 367 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 426
Query: 323 LKEPSQPLPLPSEGSLEDEELPAQRYERD 351
L P+ L P EG+ ++ P +R +D
Sbjct: 427 LSSPTVTLSAPLEGA---KDSPVRRAVKD 452
Score = 43.9 bits (102), Expect = 5e-04
Identities = 24/62 (38%), Positives = 36/62 (58%), Gaps = 5/62 (8%)
Query: 10 GSSIKIRLTVLCAKNLAKKDFFRLPDPFAKI---VVDGSGQCH--STDTVKNTLDPKWNQ 64
G S +R+ V+ +LAKKD F DP+ K+ V D + + T T+K TL+PKWN+
Sbjct: 17 GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNE 76
Query: 65 HY 66
+
Sbjct: 77 EF 78
Score = 30.4 bits (67), Expect = 6.1
Identities = 10/34 (29%), Positives = 19/34 (55%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267
P LP G+E++ G+ Y+++ + WH P +
Sbjct: 193 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 226
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 462 bits (1188), Expect = e-130
Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 331 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 390
Query: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323
R S+N ++LGPLPPGWE R + GR +++DHN++ TQ+ DPRL +
Sbjct: 391 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 442
Query: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383
P+ PA Y R+ QK R +L +++ R IF
Sbjct: 443 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 487
Query: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442
EESYR+IM + RP LK RL ++F E+GLDYGGVAREW +LL EM NPYYGLF+YS
Sbjct: 488 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 547
Query: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501
+ Y LQINP+S + N DHLSYF F+GR+ GLAVFHG ++G F PFYK +LGK I L+D
Sbjct: 548 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 607
Query: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561
+ESVD E + SL WILEND T LD FC++ FG+ Q +LKPNG + VT ENK+EY
Sbjct: 608 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 666
Query: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621
+ L + WRF+ ++ Q A +GF EL+P L+K FD+ ELEL++ GL +D+NDW+ ++
Sbjct: 667 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 726
Query: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680
K+ ++ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+L
Sbjct: 727 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 783
Query: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728
FTI + + LP+AHTCFNR+D+PPYE++E L EKLL AVE GF
Sbjct: 784 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 46.6 bits (109), Expect = 8e-05
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%)
Query: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 322
LP GWE R GR Y+V+HNNRTT +T P + +H++ Q +
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
Query: 323 LKEPSQPLPLPSEGSLEDEELPAQRYERD 351
L P+ L P EG+ ++ P +R +D
Sbjct: 306 LSSPTVTLSAPLEGA---KDSPVRRAVKD 331
Score = 30.4 bits (67), Expect = 6.1
Identities = 10/34 (29%), Positives = 19/34 (55%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267
P LP G+E++ G+ Y+++ + WH P +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 462 bits (1188), Expect = e-130
Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 331 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 390
Query: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323
R S+N ++LGPLPPGWE R + GR +++DHN++ TQ+ DPRL +
Sbjct: 391 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 442
Query: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383
P+ PA Y R+ QK R +L +++ R IF
Sbjct: 443 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 487
Query: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442
EESYR+IM + RP LK RL ++F E+GLDYGGVAREW +LL EM NPYYGLF+YS
Sbjct: 488 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 547
Query: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501
+ Y LQINP+S + N DHLSYF F+GR+ GLAVFHG ++G F PFYK +LGK I L+D
Sbjct: 548 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 607
Query: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561
+ESVD E + SL WILEND T LD FC++ FG+ Q +LKPNG + VT ENK+EY
Sbjct: 608 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 666
Query: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621
+ L + WRF+ ++ Q A +GF EL+P L+K FD+ ELEL++ GL +D+NDW+ ++
Sbjct: 667 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 726
Query: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680
K+ ++ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+L
Sbjct: 727 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 783
Query: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728
FTI + + LP+AHTCFNR+D+PPYE++E L EKLL AVE GF
Sbjct: 784 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 46.6 bits (109), Expect = 8e-05
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%)
Query: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 322
LP GWE R GR Y+V+HNNRTT +T P + +H++ Q +
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
Query: 323 LKEPSQPLPLPSEGSLEDEELPAQRYERD 351
L P+ L P EG+ ++ P +R +D
Sbjct: 306 LSSPTVTLSAPLEGA---KDSPVRRAVKD 331
Score = 30.4 bits (67), Expect = 6.1
Identities = 10/34 (29%), Positives = 19/34 (55%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267
P LP G+E++ G+ Y+++ + WH P +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 462 bits (1188), Expect = e-130
Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 444 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 503
Query: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323
R S+N ++LGPLPPGWE R + GR +++DHN++ TQ+ DPRL +
Sbjct: 504 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 555
Query: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383
P+ PA Y R+ QK R +L +++ R IF
Sbjct: 556 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 600
Query: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442
EESYR+IM + RP LK RL ++F E+GLDYGGVAREW +LL EM NPYYGLF+YS
Sbjct: 601 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 660
Query: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501
+ Y LQINP+S + N DHLSYF F+GR+ GLAVFHG ++G F PFYK +LGK I L+D
Sbjct: 661 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 720
Query: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561
+ESVD E + SL WILEND T LD FC++ FG+ Q +LKPNG + VT ENK+EY
Sbjct: 721 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 779
Query: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621
+ L + WRF+ ++ Q A +GF EL+P L+K FD+ ELEL++ GL +D+NDW+ ++
Sbjct: 780 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 839
Query: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680
K+ ++ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+L
Sbjct: 840 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 896
Query: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728
FTI + + LP+AHTCFNR+D+PPYE++E L EKLL AVE GF
Sbjct: 897 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 943
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 218
Score = 46.6 bits (109), Expect = 8e-05
Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%)
Query: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 322
LP GWE R GR Y+V+HNNRTT +T P + +H++ Q +
Sbjct: 359 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 418
Query: 323 LKEPSQPLPLPSEGSLEDEELPAQRYERD 351
L P+ L P EG+ ++ P +R +D
Sbjct: 419 LSSPTVTLSAPLEGA---KDSPVRRAVKD 444
Score = 43.9 bits (102), Expect = 5e-04
Identities = 24/62 (38%), Positives = 36/62 (58%), Gaps = 5/62 (8%)
Query: 10 GSSIKIRLTVLCAKNLAKKDFFRLPDPFAKI---VVDGSGQCH--STDTVKNTLDPKWNQ 64
G S +R+ V+ +LAKKD F DP+ K+ V D + + T T+K TL+PKWN+
Sbjct: 9 GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNE 68
Query: 65 HY 66
+
Sbjct: 69 EF 70
Score = 30.4 bits (67), Expect = 6.1
Identities = 10/34 (29%), Positives = 19/34 (55%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267
P LP G+E++ G+ Y+++ + WH P +
Sbjct: 185 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 218
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 462 bits (1188), Expect = e-130
Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 464 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 523
Query: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323
R S+N ++LGPLPPGWE R + GR +++DHN++ TQ+ DPRL +
Sbjct: 524 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 575
Query: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383
P+ PA Y R+ QK R +L +++ R IF
Sbjct: 576 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 620
Query: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442
EESYR+IM + RP LK RL ++F E+GLDYGGVAREW +LL EM NPYYGLF+YS
Sbjct: 621 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 680
Query: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501
+ Y LQINP+S + N DHLSYF F+GR+ GLAVFHG ++G F PFYK +LGK I L+D
Sbjct: 681 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 740
Query: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561
+ESVD E + SL WILEND T LD FC++ FG+ Q +LKPNG + VT ENK+EY
Sbjct: 741 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 799
Query: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621
+ L + WRF+ ++ Q A +GF EL+P L+K FD+ ELEL++ GL +D+NDW+ ++
Sbjct: 800 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 859
Query: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680
K+ ++ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+L
Sbjct: 860 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 916
Query: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728
FTI + + LP+AHTCFNR+D+PPYE++E L EKLL AVE GF
Sbjct: 917 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 963
Score = 50.4 bits (119), Expect = 6e-06
Identities = 46/172 (26%), Positives = 69/172 (40%), Gaps = 55/172 (31%)
Query: 205 QRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQG------QVYFLHTQTG 258
QR + RLR+ V ++ + P P P G + +TV G V ++HT G
Sbjct: 323 QREPSSRLRSCSVTDAVAEQGHLP----PPSAPAGRARSSTVTGGEEPTPSVAYVHTTPG 378
Query: 259 VSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----- 313
LP GWE R GR Y+V+HNNRTT +T P +
Sbjct: 379 -----------------------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 415
Query: 314 ----------HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 351
+H++ Q + L P+ L P EG+ ++ P +R +D
Sbjct: 416 GASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 464
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 218
Score = 43.9 bits (102), Expect = 5e-04
Identities = 24/62 (38%), Positives = 36/62 (58%), Gaps = 5/62 (8%)
Query: 10 GSSIKIRLTVLCAKNLAKKDFFRLPDPFAKI---VVDGSGQCH--STDTVKNTLDPKWNQ 64
G S +R+ V+ +LAKKD F DP+ K+ V D + + T T+K TL+PKWN+
Sbjct: 9 GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNE 68
Query: 65 HY 66
+
Sbjct: 69 EF 70
Score = 30.4 bits (67), Expect = 6.1
Identities = 10/34 (29%), Positives = 19/34 (55%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267
P LP G+E++ G+ Y+++ + WH P +
Sbjct: 185 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 218
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 462 bits (1188), Expect = e-130
Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 472 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 531
Query: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323
R S+N ++LGPLPPGWE R + GR +++DHN++ TQ+ DPRL +
Sbjct: 532 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 583
Query: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383
P+ PA Y R+ QK R +L +++ R IF
Sbjct: 584 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 628
Query: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442
EESYR+IM + RP LK RL ++F E+GLDYGGVAREW +LL EM NPYYGLF+YS
Sbjct: 629 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 688
Query: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501
+ Y LQINP+S + N DHLSYF F+GR+ GLAVFHG ++G F PFYK +LGK I L+D
Sbjct: 689 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 748
Query: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561
+ESVD E + SL WILEND T LD FC++ FG+ Q +LKPNG + VT ENK+EY
Sbjct: 749 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 807
Query: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621
+ L + WRF+ ++ Q A +GF EL+P L+K FD+ ELEL++ GL +D+NDW+ ++
Sbjct: 808 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 867
Query: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680
K+ ++ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+L
Sbjct: 868 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 924
Query: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728
FTI + + LP+AHTCFNR+D+PPYE++E L EKLL AVE GF
Sbjct: 925 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 971
Score = 50.4 bits (119), Expect = 6e-06
Identities = 46/172 (26%), Positives = 69/172 (40%), Gaps = 55/172 (31%)
Query: 205 QRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQG------QVYFLHTQTG 258
QR + RLR+ V ++ + P P P G + +TV G V ++HT G
Sbjct: 331 QREPSSRLRSCSVTDAVAEQGHLP----PPSAPAGRARSSTVTGGEEPTPSVAYVHTTPG 386
Query: 259 VSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----- 313
LP GWE R GR Y+V+HNNRTT +T P +
Sbjct: 387 -----------------------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 423
Query: 314 ----------HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 351
+H++ Q + L P+ L P EG+ ++ P +R +D
Sbjct: 424 GASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 472
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 226
Score = 43.9 bits (102), Expect = 5e-04
Identities = 24/62 (38%), Positives = 36/62 (58%), Gaps = 5/62 (8%)
Query: 10 GSSIKIRLTVLCAKNLAKKDFFRLPDPFAKI---VVDGSGQCH--STDTVKNTLDPKWNQ 64
G S +R+ V+ +LAKKD F DP+ K+ V D + + T T+K TL+PKWN+
Sbjct: 17 GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNE 76
Query: 65 HY 66
+
Sbjct: 77 EF 78
Score = 30.4 bits (67), Expect = 6.1
Identities = 10/34 (29%), Positives = 19/34 (55%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267
P LP G+E++ G+ Y+++ + WH P +
Sbjct: 193 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 226
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 462 bits (1188), Expect = e-130
Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410
Query: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323
R S+N ++LGPLPPGWE R + GR +++DHN++ TQ+ DPRL +
Sbjct: 411 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 462
Query: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383
P+ PA Y R+ QK R +L +++ R IF
Sbjct: 463 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 507
Query: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442
EESYR+IM + RP LK RL ++F E+GLDYGGVAREW +LL EM NPYYGLF+YS
Sbjct: 508 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 567
Query: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501
+ Y LQINP+S + N DHLSYF F+GR+ GLAVFHG ++G F PFYK +LGK I L+D
Sbjct: 568 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 627
Query: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561
+ESVD E + SL WILEND T LD FC++ FG+ Q +LKPNG + VT ENK+EY
Sbjct: 628 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 686
Query: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621
+ L + WRF+ ++ Q A +GF EL+P L+K FD+ ELEL++ GL +D+NDW+ ++
Sbjct: 687 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 746
Query: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680
K+ ++ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+L
Sbjct: 747 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 803
Query: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728
FTI + + LP+AHTCFNR+D+PPYE++E L EKLL AVE GF
Sbjct: 804 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 50.4 bits (119), Expect = 6e-06
Identities = 46/172 (26%), Positives = 69/172 (40%), Gaps = 55/172 (31%)
Query: 205 QRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQG------QVYFLHTQTG 258
QR + RLR+ V ++ + P P P G + +TV G V ++HT G
Sbjct: 210 QREPSSRLRSCSVTDAVAEQGHLP----PPSAPAGRARSSTVTGGEEPTPSVAYVHTTPG 265
Query: 259 VSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----- 313
LP GWE R GR Y+V+HNNRTT +T P +
Sbjct: 266 -----------------------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 302
Query: 314 ----------HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 351
+H++ Q + L P+ L P EG+ ++ P +R +D
Sbjct: 303 GASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 351
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 30.4 bits (67), Expect = 6.1
Identities = 10/34 (29%), Positives = 19/34 (55%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267
P LP G+E++ G+ Y+++ + WH P +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 462 bits (1188), Expect = e-130
Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%)
Query: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+
Sbjct: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410
Query: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323
R S+N ++LGPLPPGWE R + GR +++DHN++ TQ+ DPRL +
Sbjct: 411 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 462
Query: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383
P+ PA Y R+ QK R +L +++ R IF
Sbjct: 463 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 507
Query: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442
EESYR+IM + RP LK RL ++F E+GLDYGGVAREW +LL EM NPYYGLF+YS
Sbjct: 508 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 567
Query: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501
+ Y LQINP+S + N DHLSYF F+GR+ GLAVFHG ++G F PFYK +LGK I L+D
Sbjct: 568 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 627
Query: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561
+ESVD E + SL WILEND T LD FC++ FG+ Q +LKPNG + VT ENK+EY
Sbjct: 628 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 686
Query: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621
+ L + WRF+ ++ Q A +GF EL+P L+K FD+ ELEL++ GL +D+NDW+ ++
Sbjct: 687 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 746
Query: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680
K+ ++ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+L
Sbjct: 747 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 803
Query: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728
FTI + + LP+AHTCFNR+D+PPYE++E L EKLL AVE GF
Sbjct: 804 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 50.4 bits (119), Expect = 6e-06
Identities = 46/172 (26%), Positives = 69/172 (40%), Gaps = 55/172 (31%)
Query: 205 QRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQG------QVYFLHTQTG 258
QR + RLR+ V ++ + P P P G + +TV G V ++HT G
Sbjct: 210 QREPSSRLRSCSVTDAVAEQGHLP----PPSAPAGRARSSTVTGGEEPTPSVAYVHTTPG 265
Query: 259 VSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----- 313
LP GWE R GR Y+V+HNNRTT +T P +
Sbjct: 266 -----------------------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 302
Query: 314 ----------HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 351
+H++ Q + L P+ L P EG+ ++ P +R +D
Sbjct: 303 GASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 351
Score = 47.4 bits (111), Expect = 5e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 30.4 bits (67), Expect = 6.1
Identities = 10/34 (29%), Positives = 19/34 (55%)
Query: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267
P LP G+E++ G+ Y+++ + WH P +
Sbjct: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 452 bits (1164), Expect = e-127
Identities = 239/513 (46%), Positives = 322/513 (62%), Gaps = 37/513 (7%)
Query: 220 SLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDEL 279
S+ +N P+G LP G+E+R +VYF++ T + W DPR N
Sbjct: 446 SMLAAENDPYG----PLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEE----- 496
Query: 280 GPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLE 339
PLP GWE+R T G YFVDHN RTT F DPR N + + +
Sbjct: 497 -PLPEGWEIRYTREGVRYFVDHNTRTTTFKDPR-----NGKSSVTKGG------------ 538
Query: 340 DEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLK 399
P YER KL R+ L H +I VSR+ +FE+S++QIM ++P DL+
Sbjct: 539 ----PQIAYERGFRWKLAHFRY-LCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLR 593
Query: 400 KRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDH 459
+RL V FRGEEGLDYGG+AREW +LL HE+LNP Y LF+Y+ N Y LQINP S+INPDH
Sbjct: 594 RRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDH 653
Query: 460 LSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN 519
LSYF F+GR + +A+FHG +I+ GF++PFYK++L K + + DLES+D E + SL+WI +N
Sbjct: 654 LSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN 713
Query: 520 DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQF 578
+I L+ F V+ G++ H+LK G N+ VTEENK EY+ L WRF RG++ Q
Sbjct: 714 NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQT 773
Query: 579 LALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQ 638
A GFNE++P L+ FD+KELE+++ G+ ++DL DW+ NT +H +S + WFWQ
Sbjct: 774 KAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQ 833
Query: 639 AVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHT 698
V+ D E R RLLQFVTG+ R+PL GF L GS GP+ F I + +T LP++HT
Sbjct: 834 FVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSN---GPQKFCIEKVGKDT-WLPRSHT 889
Query: 699 CFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 731
CFNR+D+PPY+SYE+L EKLL A+EET GF E
Sbjct: 890 CFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 922
Score = 68.6 bits (166), Expect = 2e-11
Identities = 38/114 (33%), Positives = 55/114 (48%), Gaps = 18/114 (15%)
Query: 208 QAQRLRNPDVRGSLQTPQNRPHGHQSPE-LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPR 266
+A + R PD P + G+ + E LP G+EQR G+ Y++ T +TW P+
Sbjct: 325 EAAKSRQPD---GCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ 381
Query: 267 IPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQ 320
PLPPGWE R R+Y+VDHN RTT + P + + N +
Sbjct: 382 --------------PLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFE 421
Score = 36.6 bits (83), Expect = 0.085
Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 21/165 (12%)
Query: 6 TRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQH 65
+ + +++++TV AK KK++F + ++VVDG + T ++ +PKW++
Sbjct: 11 SNNHSGRLQLQVTVSSAKLKRKKNWFGTAI-YTEVVVDG--EITKTAKSSSSSNPKWDEQ 67
Query: 66 YDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSD 125
+ V ++ VW+H+ L LL A LK ++
Sbjct: 68 LTVNVTPQTTLEFQVWSHRT---------LKADALLGKATIDLKQA-------LLIHNRK 111
Query: 126 TDAVRGQIVVSLQTRDRIG-TGGSVVDCRGL-LENEGTVYEDSGP 168
+ V+ Q+ +SL+ ++ I TG V GL +E E S P
Sbjct: 112 LERVKEQLKLSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSP 156
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 450 bits (1158), Expect = e-126
Identities = 237/548 (43%), Positives = 330/548 (60%), Gaps = 61/548 (11%)
Query: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLN----------------------- 272
LP G+E+RT +G+ Y++ T +TW P N
Sbjct: 332 LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFL 391
Query: 273 ------SVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPR-------------- 312
S + D LGPLPPGWE R +GR+Y+V+HN RTTQ+ DPR
Sbjct: 392 YQSSSASTDHDPLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGW 450
Query: 313 --------LHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELS 364
+ + ++H + P P G+ + R R + + L H +
Sbjct: 451 EMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNA 510
Query: 365 LQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYL 424
L H +I VSR+ +FE+S++QIM M+P DL++RL + RGEEGLDYGG+AREW +L
Sbjct: 511 LPS----HVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFL 566
Query: 425 LCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGF 484
L HE+LNP Y LF+Y+ N Y LQINP SSINPDHL+YF F+GR + +A++HG +I+ GF
Sbjct: 567 LSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGF 626
Query: 485 TVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHE 543
T+PFYK++L K L DLES+DPE + S+VWI EN++ L+ F + G++ HE
Sbjct: 627 TLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHE 686
Query: 544 LKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELE 603
LK G ++ VTEENK+EY+ L +WRF RG+E Q A GFNE+ P L+ FD+KELE
Sbjct: 687 LKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELE 746
Query: 604 LIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPL 663
L++ G+ +ID++DW+ +T +H +S ++WFWQ V+ D E+R RLLQFVTG+ R+P+
Sbjct: 747 LMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPV 806
Query: 664 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 723
GF L GS GP+ F I + T LP++HTCFNR+D+PPY+SYE+L EKLL A+E
Sbjct: 807 GGFAELIGSN---GPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREKLLYAIE 862
Query: 724 ETCGFAVE 731
ET GF E
Sbjct: 863 ETEGFGQE 870
Score = 71.2 bits (173), Expect = 3e-12
Identities = 52/165 (31%), Positives = 71/165 (43%), Gaps = 41/165 (24%)
Query: 157 ENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPD 216
E V S P PLS P P T S A A +P++ + P
Sbjct: 246 EEPSVVGVTSPPAAPLSV---TPNPNTTSLPAPA---------TPAEGEE--------PS 285
Query: 217 VRGSLQTPQNRPHGHQSPE-LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVN 275
G+ Q P Q+P+ LP G+EQR G+VY++ T +TW P
Sbjct: 286 TSGTQQLPA----AAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP---------- 331
Query: 276 CDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQ 320
LPPGWE R+ GR Y+VDHN RTT + P ++ N++
Sbjct: 332 ------LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYE 370
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 449 bits (1155), Expect = e-126
Identities = 233/502 (46%), Positives = 322/502 (64%), Gaps = 37/502 (7%)
Query: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPR--IPRDLNSVNC----DELGPLPPGWEVR 289
LP+G+E R G+ +F+ T +TW DPR IP L ++LGPLPPGWE R
Sbjct: 423 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEER 482
Query: 290 STVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYE 349
+ GRI++++HN + TQ+ DPRL ++ + P+ P Y
Sbjct: 483 THTDGRIFYINHNIKRTQWEDPRLENVA-----ITGPAVP------------------YS 519
Query: 350 RDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKD-LKKRLMVKFRG 408
RD +K + R +L Q +++ R + E+SYR+IM ++ D LK RL ++F G
Sbjct: 520 RDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDG 579
Query: 409 EEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVG 467
E+GLDYGGVAREW +L+ EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+G
Sbjct: 580 EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIG 639
Query: 468 RIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDH 527
R+ G+AV+HG ++G F PFYK +L KPI L D+ESVD E + SL WILEND T LD
Sbjct: 640 RVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE-LDL 698
Query: 528 TFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNE 587
F ++ FG+ QHELK G + VT +NKKEY+ L + WRF+ I+ Q A ++GF E
Sbjct: 699 RFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFE 758
Query: 588 LIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEE 646
LIPQ L+K FD+ ELEL++ GL +D+NDW+ +T+ K+ A+ +++WFW+AV D E
Sbjct: 759 LIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSE 818
Query: 647 RRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIP 706
+R RLLQFVTG++RVP+ GF L GS GP+ FT+ + LP+AHTCFNR+D+P
Sbjct: 819 KRIRLLQFVTGTSRVPMNGFAELYGSN---GPQSFTVEQW-GTPEKLPRAHTCFNRLDLP 874
Query: 707 PYESYEKLYEKLLTAVEETCGF 728
PYES+E+L++KL A+E T GF
Sbjct: 875 PYESFEELWDKLQMAIENTQGF 896
Score = 45.4 bits (106), Expect = 2e-04
Identities = 18/30 (60%), Positives = 22/30 (73%)
Query: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 311
LPPGWE + GR Y+VDHN+RTT +T P
Sbjct: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKP 379
Score = 45.1 bits (105), Expect = 2e-04
Identities = 18/34 (52%), Positives = 23/34 (67%)
Query: 278 ELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 311
E PLPPGWE R + GR Y+V+H +R TQ+ P
Sbjct: 189 EPSPLPPGWEERQDILGRTYYVNHESRRTQWKRP 222
Score = 38.5 bits (88), Expect = 0.022
Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 4/54 (7%)
Query: 15 IRLTVLCAKNLAKKDFFRLPDPFAKIVV----DGSGQCHSTDTVKNTLDPKWNQ 64
+R+ V+ LAKKD DP+ ++ + +G T T+K +L+PKWN+
Sbjct: 21 VRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNE 74
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 449 bits (1155), Expect = e-126
Identities = 233/502 (46%), Positives = 322/502 (64%), Gaps = 37/502 (7%)
Query: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPR--IPRDLNSVNC----DELGPLPPGWEVR 289
LP+G+E R G+ +F+ T +TW DPR IP L ++LGPLPPGWE R
Sbjct: 770 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEER 829
Query: 290 STVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYE 349
+ GRI++++HN + TQ+ DPRL ++ + P+ P Y
Sbjct: 830 THTDGRIFYINHNIKRTQWEDPRLENVA-----ITGPAVP------------------YS 866
Query: 350 RDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKD-LKKRLMVKFRG 408
RD +K + R +L Q +++ R + E+SYR+IM ++ D LK RL ++F G
Sbjct: 867 RDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDG 926
Query: 409 EEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVG 467
E+GLDYGGVAREW +L+ EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+G
Sbjct: 927 EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIG 986
Query: 468 RIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDH 527
R+ G+AV+HG ++G F PFYK +L KPI L D+ESVD E + SL WILEND T LD
Sbjct: 987 RVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE-LDL 1045
Query: 528 TFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNE 587
F ++ FG+ QHELK G + VT +NKKEY+ L + WRF+ I+ Q A ++GF E
Sbjct: 1046 RFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFE 1105
Query: 588 LIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEE 646
LIPQ L+K FD+ ELEL++ GL +D+NDW+ +T+ K+ A+ +++WFW+AV D E
Sbjct: 1106 LIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSE 1165
Query: 647 RRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIP 706
+R RLLQFVTG++RVP+ GF L GS GP+ FT+ + LP+AHTCFNR+D+P
Sbjct: 1166 KRIRLLQFVTGTSRVPMNGFAELYGSN---GPQSFTVEQW-GTPEKLPRAHTCFNRLDLP 1221
Query: 707 PYESYEKLYEKLLTAVEETCGF 728
PYES+E+L++KL A+E T GF
Sbjct: 1222 PYESFEELWDKLQMAIENTQGF 1243
Score = 45.4 bits (106), Expect = 2e-04
Identities = 18/30 (60%), Positives = 22/30 (73%)
Query: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 311
LPPGWE + GR Y+VDHN+RTT +T P
Sbjct: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKP 726
Score = 45.1 bits (105), Expect = 2e-04
Identities = 18/34 (52%), Positives = 23/34 (67%)
Query: 278 ELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 311
E PLPPGWE R + GR Y+V+H +R TQ+ P
Sbjct: 536 EPSPLPPGWEERQDILGRTYYVNHESRRTQWKRP 569
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 430 bits (1106), Expect = e-120
Identities = 218/451 (48%), Positives = 295/451 (65%), Gaps = 27/451 (5%)
Query: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDE 341
LPPGWE++ T G YFVDHN RTT F DPR P G+ +
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR------------------PGFESGTKQGS 48
Query: 342 ELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKR 401
R R + + L H +L H +I VSR+ +FE+S++QIM M+P DL++R
Sbjct: 49 PGAYDRSFRWKYHQFRFLCHSNALPS----HVKISVSRQTLFEDSFQQIMNMKPYDLRRR 104
Query: 402 LMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLS 461
L + RGEEGLDYGG+AREW +LL HE+LNP Y LF+Y+ N Y LQINP SSINPDHL+
Sbjct: 105 LYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLT 164
Query: 462 YFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDI 521
YF F+GR + +A++HG +I+ GFT+PFYK++L K L DLES+DPE + S+VWI EN++
Sbjct: 165 YFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNL 224
Query: 522 TPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLA 580
L+ F + G++ HELK G ++ VTEENK+EY+ L +WRF RG+E Q A
Sbjct: 225 EECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKA 284
Query: 581 LQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAV 640
GFNE+ P L+ FD+KELEL++ G+ +ID++DW+ +T +H +S ++WFWQ V
Sbjct: 285 FLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVV 344
Query: 641 ETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCF 700
+ D E+R RLLQFVTG+ R+P+ GF L GS GP+ F I + T LP++HTCF
Sbjct: 345 KEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSN---GPQKFCIDKVGKET-WLPRSHTCF 400
Query: 701 NRIDIPPYESYEKLYEKLLTAVEETCGFAVE 731
NR+D+PPY+SYE+L EKLL A+EET GF E
Sbjct: 401 NRLDLPPYKSYEQLREKLLYAIEETEGFGQE 431
Score = 34.7 bits (78), Expect = 0.32
Identities = 15/35 (42%), Positives = 21/35 (60%)
Query: 232 QSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPR 266
Q P LP G+E + T +G YF+ T +T+ DPR
Sbjct: 3 QEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR 37
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 360 bits (925), Expect = 2e-99
Identities = 187/388 (48%), Positives = 255/388 (65%), Gaps = 8/388 (2%)
Query: 348 YERDLVQKLKVLRHELSLQQPQAGHCRIE--VSREEIFEESYRQIMKMRPKDLKK-RLMV 404
Y RD KL+ +L + G +I+ + R+ + E ++ Q+M K+L++ +L V
Sbjct: 1223 YRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYV 1282
Query: 405 KFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFH 464
F GEEGLDY G +RE+ +LL E+ NPYYGLF+YS ++ Y +QI+P S+ +HL +F
Sbjct: 1283 TFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFR 1342
Query: 465 FVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPV 524
F GRI+GLA+ H + ++ FT PFYK LL P LSDLE +D E H+SL W+ +N+IT +
Sbjct: 1343 FSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI 1402
Query: 525 LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKG 584
LD TF V FG++ + ELK G N VTE+NKKEY+ V WR RG+ Q AL +G
Sbjct: 1403 LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRG 1462
Query: 585 FNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETF 643
F E++ L+ FD +ELEL+I G +IDLNDW++NT + D + ++RWFW AVE F
Sbjct: 1463 FYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERF 1522
Query: 644 DEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRI 703
+ E+R RLLQFVTG++ VP +GF AL+GS G R F I T +LP+AHTCFNR+
Sbjct: 1523 NNEQRLRLLQFVTGTSSVPYEGFAALRGSNGL---RRFCIEKWGKIT-SLPRAHTCFNRL 1578
Query: 704 DIPPYESYEKLYEKLLTAVEETCGFAVE 731
D+PPY SY LYEKLLTAVEET F +E
Sbjct: 1579 DLPPYPSYSMLYEKLLTAVEETSTFGLE 1606
Score = 47.4 bits (111), Expect = 5e-05
Identities = 35/98 (35%), Positives = 42/98 (42%), Gaps = 9/98 (9%)
Query: 219 GSLQTPQNRPHGHQSPELPEGYEQRTTV-----QGQVYFLHTQTGVSTWHDPRIPRDLNS 273
G Q P GH PEG E +G+ LH VS R P +
Sbjct: 767 GPWQDELAAPSGHVERS-PEGLESPVAGPSNRREGECPILHNSQPVSQLPSLR-PEHHHY 824
Query: 274 VNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 311
DE PLPP WE R GR+++VDH NRTT + P
Sbjct: 825 PTIDE--PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
Score = 46.6 bits (109), Expect = 8e-05
Identities = 23/48 (47%), Positives = 31/48 (64%), Gaps = 3/48 (6%)
Query: 269 RDL-NSVN--CDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
RDL N +N D LP GWE+++ G+ +FVDHN+R T F DPR+
Sbjct: 1004 RDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
Score = 35.0 bits (79), Expect = 0.25
Identities = 15/34 (44%), Positives = 23/34 (67%)
Query: 235 ELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
ELP G+E +T QG+ +F+ + +T+ DPRIP
Sbjct: 1019 ELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIP 1052
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 360 bits (925), Expect = 2e-99
Identities = 192/424 (45%), Positives = 268/424 (63%), Gaps = 11/424 (2%)
Query: 315 HIMNHQCQLKEP-SQPLPLP--SEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQ--PQ 369
H + H + P P+ P S G+ Y+RD KL+ +L +
Sbjct: 1153 HALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQG 1212
Query: 370 AGHCRIEVSREEIFEESYRQIMKMRPKDLKK-RLMVKFRGEEGLDYGGVAREWLYLLCHE 428
G ++ + R+ + E+++ QIM KDL++ +L V F GEEGLDY G +RE+ +L+ E
Sbjct: 1213 PGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRE 1272
Query: 429 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 488
+ NPYYGLF+YS ++ Y +QI+P S+ +H +F F GRI+GLA+ H + ++ FT PF
Sbjct: 1273 LFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPF 1332
Query: 489 YKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNG 548
YK LL LSDLE +D E H+SL W+ +NDI +LD TF V FG+I + ELKP G
Sbjct: 1333 YKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGG 1392
Query: 549 RNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGG 608
N+PVTE+NKKEY+ V WR RG+ Q +L +GF E++ L+ FD +ELEL+I G
Sbjct: 1393 ANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAG 1452
Query: 609 LDKIDLNDWKSNTRLKHCVADSNIV-RWFWQAVETFDEERRARLLQFVTGSTRVPLQGFK 667
+IDL+DW++NT + D++IV RWFW AVE F+ E+R RLLQFVTG++ +P +GF
Sbjct: 1453 TAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFA 1512
Query: 668 ALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCG 727
+L+GS GPR F + T LP+AHTCFNR+D+PPY S+ LYEKLLTAVEET
Sbjct: 1513 SLRGSN---GPRRFCVEKWGKIT-ALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETST 1568
Query: 728 FAVE 731
F +E
Sbjct: 1569 FGLE 1572
Score = 47.4 bits (111), Expect = 5e-05
Identities = 19/32 (59%), Positives = 24/32 (75%)
Query: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
LP GWE++ G+ +FVDHN+RTT F DPRL
Sbjct: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
Score = 46.2 bits (108), Expect = 1e-04
Identities = 58/219 (26%), Positives = 85/219 (38%), Gaps = 41/219 (18%)
Query: 181 PYTDSTGAAAGGGNCRFVESPS-QDQRLQAQRLRNPDV---------RGSLQTPQNRPHG 230
P S + G+ V+ PS +D+ A+ PD RGSL+
Sbjct: 693 PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGSLE---GAAAA 749
Query: 231 HQSPELPEGY--EQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELG------PL 282
+SP EG E + T +G TG S + + R L SV D L
Sbjct: 750 AESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQRVDEAL 809
Query: 283 PPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEE 342
PP WE R GRI++VDH NRTT + P P P L S++ E
Sbjct: 810 PPNWEARIDSHGRIFYVDHVNRTTTWQRP------------TAPPAPQVLQRSNSIQQME 857
Query: 343 LPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREE 381
+RY+ +R ++ ++P+ I+ + EE
Sbjct: 858 QLNRRYQS--------IRRTMTNERPEENTNAIDGAGEE 888
Score = 33.1 bits (74), Expect = 0.94
Identities = 13/34 (38%), Positives = 22/34 (64%)
Query: 235 ELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
ELP G+E + QG+ +F+ + +T+ DPR+P
Sbjct: 986 ELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLP 1019
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 330 bits (846), Expect = 3e-90
Identities = 165/351 (47%), Positives = 229/351 (65%), Gaps = 4/351 (1%)
Query: 375 IEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYY 434
+ V R+ +FE+SYR++ + P+++K RL + F GEEG D GG+ REW ++ EM NP Y
Sbjct: 4019 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMY 4078
Query: 435 GLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLG 494
LF+ S + INP S NP+HLSYF FVGRI+ AV+ + FT FYK +LG
Sbjct: 4079 ALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILG 4138
Query: 495 KPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPV 553
K ++ +D+ES D ++ LV++LEND++ + D TF E FG +LKPNG N+ V
Sbjct: 4139 KSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILV 4198
Query: 554 TEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKID 613
TEENKKEYV L R I Q A +GF E+IP+ L+ F ++ELEL+I GL ID
Sbjct: 4199 TEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTID 4258
Query: 614 LNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGST 673
++D KSNT ++S ++WFW+A+ +FD+ RA+ LQFVTG+++VPLQGF AL+G
Sbjct: 4259 IDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMN 4318
Query: 674 GAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEE 724
G + F IH D +TD LP AHTCFN++D+P YES+EKL LL A++E
Sbjct: 4319 GI---QKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQE 4366
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 272 bits (695), Expect = 9e-73
Identities = 149/353 (42%), Positives = 211/353 (59%), Gaps = 9/353 (2%)
Query: 377 VSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGL 436
V R+ IF S + K LK+ + V+F GEEG+ G V REW +L +E++NP Y L
Sbjct: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYAL 615
Query: 437 FQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKP 496
F S D Q N +S +NPDHL+YF F G+I+GLA+ H +N FT FYK +LG P
Sbjct: 616 FTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP 674
Query: 497 IQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTE 555
+ D+ S+DPE K+L WIL+NDI+ + L+ TF VE + FG + + LKP G ++ VT+
Sbjct: 675 VNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQ 734
Query: 556 ENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLN 615
NK EYV+L R R I+ Q A +GF+ IP L++ FD+ ELEL++ G+ +ID++
Sbjct: 735 NNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVS 794
Query: 616 DWKSNTR-LKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTG 674
DW NT + +++WFW+ VE +E R LLQFVTGS+RVP GF + G +G
Sbjct: 795 DWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSG 854
Query: 675 AAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCG 727
FTI + + LP + TC N + +P Y S E L ++LL A+ CG
Sbjct: 855 LQN---FTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALH--CG 902
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 197 bits (502), Expect = 2e-50
Identities = 121/367 (32%), Positives = 201/367 (54%), Gaps = 22/367 (5%)
Query: 372 HCRIEVSREEIFEESY---RQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHE 428
+ R++V R+ I +++ I P DLKK+L V+F GE+G+D GGV++E+ L+ E
Sbjct: 519 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 578
Query: 429 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 488
+ NP G+F Y ++ + NP S + F +G ++GLA+++ ++ F +
Sbjct: 579 IFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCILDVHFPMVV 634
Query: 489 YKQLLGKPIQLSDLESVDPELHKSLVWILE--NDITPVLDHTFCVEH-NAFGRILQHELK 545
Y++L+GK DL P L++SL +LE ++ + TF + + FG + ++LK
Sbjct: 635 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 694
Query: 546 PNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK-PFDQKELEL 604
NG +P+T EN+KE+V LY ++ + +E QF A ++GF+ + + LK F +E+EL
Sbjct: 695 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 754
Query: 605 IIGGLDKIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPL 663
+I G +D + T DS ++R FW+ V +F +E++ LQF TG+ R P+
Sbjct: 755 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 814
Query: 664 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 723
G L+ GP +T+ LP +HTCFN + +P Y S EKL E+LL A+
Sbjct: 815 GGLGKLKMIIAKNGP----------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 864
Query: 724 ETCGFAV 730
GF +
Sbjct: 865 YAKGFGM 871
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 197 bits (502), Expect = 2e-50
Identities = 121/367 (32%), Positives = 201/367 (54%), Gaps = 22/367 (5%)
Query: 372 HCRIEVSREEIFEESY---RQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHE 428
+ R++V R+ I +++ I P DLKK+L V+F GE+G+D GGV++E+ L+ E
Sbjct: 499 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 558
Query: 429 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 488
+ NP G+F Y ++ + NP S + F +G ++GLA+++ ++ F +
Sbjct: 559 IFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCILDVHFPMVV 614
Query: 489 YKQLLGKPIQLSDLESVDPELHKSLVWILE--NDITPVLDHTFCVEH-NAFGRILQHELK 545
Y++L+GK DL P L++SL +LE ++ + TF + + FG + ++LK
Sbjct: 615 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 674
Query: 546 PNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK-PFDQKELEL 604
NG +P+T EN+KE+V LY ++ + +E QF A ++GF+ + + LK F +E+EL
Sbjct: 675 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 734
Query: 605 IIGGLDKIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPL 663
+I G +D + T DS ++R FW+ V +F +E++ LQF TG+ R P+
Sbjct: 735 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 794
Query: 664 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 723
G L+ GP +T+ LP +HTCFN + +P Y S EKL E+LL A+
Sbjct: 795 GGLGKLKMIIAKNGP----------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 844
Query: 724 ETCGFAV 730
GF +
Sbjct: 845 YAKGFGM 851
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 197 bits (502), Expect = 2e-50
Identities = 121/367 (32%), Positives = 201/367 (54%), Gaps = 22/367 (5%)
Query: 372 HCRIEVSREEIFEESY---RQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHE 428
+ R++V R+ I +++ I P DLKK+L V+F GE+G+D GGV++E+ L+ E
Sbjct: 522 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 581
Query: 429 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 488
+ NP G+F Y ++ + NP S + F +G ++GLA+++ ++ F +
Sbjct: 582 IFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCILDVHFPMVV 637
Query: 489 YKQLLGKPIQLSDLESVDPELHKSLVWILE--NDITPVLDHTFCVEH-NAFGRILQHELK 545
Y++L+GK DL P L++SL +LE ++ + TF + + FG + ++LK
Sbjct: 638 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 697
Query: 546 PNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK-PFDQKELEL 604
NG +P+T EN+KE+V LY ++ + +E QF A ++GF+ + + LK F +E+EL
Sbjct: 698 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 757
Query: 605 IIGGLDKIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPL 663
+I G +D + T DS ++R FW+ V +F +E++ LQF TG+ R P+
Sbjct: 758 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 817
Query: 664 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 723
G L+ GP +T+ LP +HTCFN + +P Y S EKL E+LL A+
Sbjct: 818 GGLGKLKMIIAKNGP----------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 867
Query: 724 ETCGFAV 730
GF +
Sbjct: 868 YAKGFGM 874
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 192 bits (488), Expect = 9e-49
Identities = 122/373 (32%), Positives = 192/373 (51%), Gaps = 31/373 (8%)
Query: 375 IEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYY 434
++V R + +S ++ + R DLKK+L V F GE GLD GG+ +EW LL ++ +P Y
Sbjct: 419 MKVRRTHLVSDSLDELTRKRA-DLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDY 477
Query: 435 GLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLG 494
G+F Y D+ + SS D+ S F VG +MGLAV++ ++ F YK+LL
Sbjct: 478 GMFTYHKDS----HCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLS 533
Query: 495 KPI--------------QLSDLESVDPELHKSLVWIL--ENDITPVLDHTFCVEHNAFGR 538
PI + DL + PEL L +L E ++ TF V FG
Sbjct: 534 PPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGI 593
Query: 539 ILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFD 598
I + LKP G + VT +N+KEYV+LY ++ + I QF A GF+ + + L
Sbjct: 594 IKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLR 653
Query: 599 QKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGS 658
+E+E+++ G +D++ + +T+ +++FW V F + + +LL F TGS
Sbjct: 654 PEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGS 713
Query: 659 TRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKL 718
RVP+ G L F I + +T+ LP AHTCFN++ +PPY+S + L +KL
Sbjct: 714 DRVPVGGMADLN----------FKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
Query: 719 LTAVEETCGFAVE 731
+ + + GF +E
Sbjct: 764 IIGISNSEGFGLE 776
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 187 bits (476), Expect = 2e-47
Identities = 133/400 (33%), Positives = 204/400 (51%), Gaps = 43/400 (10%)
Query: 355 KLKVLRHELSLQQPQAGHCRI--EVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGL 412
K+ + EL + H ++ +VSR + E S + D K V F+ EE L
Sbjct: 442 KVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEAL 501
Query: 413 DYGGVAREWLYLLCHEMLNPYYGLF-QYSTDNIYMLQINPDSSINPDHL--SYFHFVGRI 469
D+GG REW L+C + + LF ++S +N ++ NP+ P HL + F GR+
Sbjct: 502 DWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPN---RPAHLRLKMYEFAGRL 558
Query: 470 MGLAVFH----GHY---INGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV-WILENDI 521
+G ++ G Y + FT F Q++G + E+ DPE +KS V +IL ND+
Sbjct: 559 VGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDM 618
Query: 522 TPVLDHTFCVE-HNAFGRILQH-ELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFL 579
+ ++ F E +N G++ + EL G PVT NK Y+ L +R ++ +
Sbjct: 619 SE-MELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVE 677
Query: 580 ALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVA-------DSNI 632
KG NEL+P++LL FD+ ELEL++ G I ++D+K+ H V +
Sbjct: 678 HFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKA-----HAVVVGGSWHFREKV 732
Query: 633 VRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANT-D 691
+RWFW V + +E ARLLQF TGS+++P GF AL S +I A T
Sbjct: 733 MRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS----------FQIIAAPTHS 782
Query: 692 NLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETC-GFAV 730
LP AHTCFN++ +P Y+SYE+++ L A+ E C GF +
Sbjct: 783 TLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGM 822
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 176 bits (447), Expect = 5e-44
Identities = 121/382 (31%), Positives = 194/382 (50%), Gaps = 24/382 (6%)
Query: 360 RHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRG-----EEGLDY 414
+ E+ P + + R I+E++Y ++ DLKKR+ V E G+D
Sbjct: 710 KQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDG 769
Query: 415 GGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS--INPDHLSYFHFVGRIMGL 472
GG+ RE+L L NP G F+ T N +L NP + + +++F+GR++G
Sbjct: 770 GGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGK 827
Query: 473 AVFHGHYINGGFTVPFYKQLLGKP--IQLSDLESVDPELHKSLVWI--LENDITPVLDHT 528
A++ + F F +LLG + + L S+DPE++K+L+++ E+D+ L
Sbjct: 828 ALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEE-LGLN 886
Query: 529 FCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNEL 588
F V +N G ELK G+++PVT N+ Y+ L ++R R I LA ++G +
Sbjct: 887 FTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANV 946
Query: 589 IPQHLLKPFDQKELELIIGGLD-KIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEE 646
+ L+ FDQ+E++++I G I L D KS T AD +++ FW+ VE F +E
Sbjct: 947 VSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDE 1006
Query: 647 RRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIP 706
+ +LL+FVT +R PL GFK L + F IH ++ + LP A TC N + +P
Sbjct: 1007 EKRKLLKFVTSCSRPPLLGFKELYPA--------FCIHNGGSDLERLPTASTCMNLLKLP 1058
Query: 707 PYESYEKLYEKLLTAVEETCGF 728
+ L KLL A+E GF
Sbjct: 1059 EFYDETLLRSKLLYAIECAAGF 1080
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 176 bits (446), Expect = 7e-44
Identities = 111/358 (31%), Positives = 184/358 (51%), Gaps = 18/358 (5%)
Query: 377 VSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGL 436
V RE I ++ + K + D KK L V F GE+ +D GGV +E+ L+ E+L+P YG+
Sbjct: 705 VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 764
Query: 437 FQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKP 496
F+Y D+ L D + L FH +G I GLA+++ ++ F + YK+LL K
Sbjct: 765 FRYYEDS--RLIWFSDKTFEDSDL--FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 820
Query: 497 IQLSDLESVDPELHKSLVWIL---ENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPV 553
L DL+ + P++ +S+ +L E+DI F + FG EL NG + V
Sbjct: 821 PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAV 880
Query: 554 TEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKID 613
++N++E+V YV++ F + + + F A GF+++ +L F EL+ ++ G D
Sbjct: 881 NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYD 940
Query: 614 LNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGS 672
+ + NT K A+ ++ FW+ E++ + L F+TGS R+P+ G K+L+
Sbjct: 941 WKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLK-- 998
Query: 673 TGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 730
I + LP +HTCFN +D+P Y E L KL+ A++ GF++
Sbjct: 999 --------LVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1048
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 176 bits (446), Expect = 7e-44
Identities = 111/358 (31%), Positives = 184/358 (51%), Gaps = 18/358 (5%)
Query: 377 VSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGL 436
V RE I ++ + K + D KK L V F GE+ +D GGV +E+ L+ E+L+P YG+
Sbjct: 713 VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 772
Query: 437 FQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKP 496
F+Y D+ L D + L FH +G I GLA+++ ++ F + YK+LL K
Sbjct: 773 FRYYEDS--RLIWFSDKTFEDSDL--FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 828
Query: 497 IQLSDLESVDPELHKSLVWIL---ENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPV 553
L DL+ + P++ +S+ +L E+DI F + FG EL NG + V
Sbjct: 829 PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAV 888
Query: 554 TEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKID 613
++N++E+V YV++ F + + + F A GF+++ +L F EL+ ++ G D
Sbjct: 889 NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYD 948
Query: 614 LNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGS 672
+ + NT K A+ ++ FW+ E++ + L F+TGS R+P+ G K+L+
Sbjct: 949 WKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLK-- 1006
Query: 673 TGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 730
I + LP +HTCFN +D+P Y E L KL+ A++ GF++
Sbjct: 1007 --------LVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1056
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,378,958
Number of Sequences: 37866
Number of extensions: 1552295
Number of successful extensions: 4413
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 88
Number of HSP's that attempted gapping in prelim test: 3869
Number of HSP's gapped (non-prelim): 345
length of query: 731
length of database: 18,247,518
effective HSP length: 110
effective length of query: 621
effective length of database: 14,082,258
effective search space: 8745082218
effective search space used: 8745082218
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.