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Search of human proteins with 31317280
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31317280 WD repeat domain 20 isoform 2 [Homo sapiens]
(569 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31317280 WD repeat domain 20 isoform 2 [Homo sapiens] 1174 0.0
gi|31317274 WD repeat domain 20 isoform 1 [Homo sapiens] 1164 0.0
gi|31317278 WD repeat domain 20 isoform 3 [Homo sapiens] 1017 0.0
gi|31317276 WD repeat domain 20 isoform 4 [Homo sapiens] 885 0.0
gi|62945417 dystrophia myotonica-containing WD repeat motif prot... 636 0.0
gi|13376840 WD repeat domain 61 [Homo sapiens] 59 2e-08
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 56 8e-08
gi|26665869 WD repeat domain 51B [Homo sapiens] 55 2e-07
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 53 7e-07
gi|19913369 transducin beta-like 3 [Homo sapiens] 53 9e-07
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 52 1e-06
gi|16554629 WD repeat domain 5 [Homo sapiens] 51 2e-06
gi|16554627 WD repeat domain 5 [Homo sapiens] 51 2e-06
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 51 2e-06
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 51 2e-06
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 51 3e-06
gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens] 50 4e-06
gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens] 49 9e-06
gi|148727341 serine/threonine kinase receptor associated protein... 49 2e-05
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 48 2e-05
gi|113865883 WD repeat domain 38 [Homo sapiens] 48 2e-05
gi|189571685 WD repeat, sterile alpha motif and U-box domain con... 48 2e-05
gi|189571683 WD repeat, sterile alpha motif and U-box domain con... 48 2e-05
gi|189571681 WD repeat, sterile alpha motif and U-box domain con... 48 2e-05
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 47 4e-05
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 47 6e-05
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 47 6e-05
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 47 6e-05
gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens] 47 6e-05
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 46 8e-05
>gi|31317280 WD repeat domain 20 isoform 2 [Homo sapiens]
Length = 569
Score = 1174 bits (3036), Expect = 0.0
Identities = 569/569 (100%), Positives = 569/569 (100%)
Query: 1 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60
MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG
Sbjct: 1 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60
Query: 61 NGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLV 120
NGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLV
Sbjct: 61 NGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLV 120
Query: 121 GFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE 180
GFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE
Sbjct: 121 GFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE 180
Query: 181 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ 240
HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ
Sbjct: 181 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ 240
Query: 241 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 300
DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG
Sbjct: 241 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 300
Query: 301 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS 360
HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS
Sbjct: 301 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS 360
Query: 361 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 420
RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT
Sbjct: 361 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 420
Query: 421 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR 480
PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR
Sbjct: 421 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR 480
Query: 481 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI 540
NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI
Sbjct: 481 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI 540
Query: 541 FLEDCIVTACQEGFICTWGRPGKVVSFNP 569
FLEDCIVTACQEGFICTWGRPGKVVSFNP
Sbjct: 541 FLEDCIVTACQEGFICTWGRPGKVVSFNP 569
>gi|31317274 WD repeat domain 20 isoform 1 [Homo sapiens]
Length = 581
Score = 1164 bits (3011), Expect = 0.0
Identities = 565/568 (99%), Positives = 566/568 (99%)
Query: 1 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60
MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG
Sbjct: 1 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60
Query: 61 NGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLV 120
NGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLV
Sbjct: 61 NGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLV 120
Query: 121 GFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE 180
GFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE
Sbjct: 121 GFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE 180
Query: 181 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ 240
HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ
Sbjct: 181 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ 240
Query: 241 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 300
DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG
Sbjct: 241 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 300
Query: 301 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS 360
HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS
Sbjct: 301 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS 360
Query: 361 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 420
RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT
Sbjct: 361 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 420
Query: 421 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR 480
PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR
Sbjct: 421 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR 480
Query: 481 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI 540
NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI
Sbjct: 481 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI 540
Query: 541 FLEDCIVTACQEGFICTWGRPGKVVSFN 568
FLEDCIVTACQEGFICTWGRPGKV S +
Sbjct: 541 FLEDCIVTACQEGFICTWGRPGKVGSLS 568
>gi|31317278 WD repeat domain 20 isoform 3 [Homo sapiens]
Length = 508
Score = 1017 bits (2629), Expect = 0.0
Identities = 505/569 (88%), Positives = 507/569 (89%), Gaps = 61/569 (10%)
Query: 1 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60
MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG
Sbjct: 1 MATEGGGKEMNEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQSG 60
Query: 61 NGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLV 120
NGDRLCFNVGRELYFYI YKG +
Sbjct: 61 NGDRLCFNVGRELYFYI------------------YKGVR-------------------- 82
Query: 121 GFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE 180
+RLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE
Sbjct: 83 -----------------------KRLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVE 119
Query: 181 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ 240
HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ
Sbjct: 120 HTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQ 179
Query: 241 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 300
DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG
Sbjct: 180 DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 239
Query: 301 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS 360
HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS
Sbjct: 240 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDS 299
Query: 361 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 420
RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT
Sbjct: 300 RPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTT 359
Query: 421 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR 480
PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR
Sbjct: 360 PGNSVPPPLPRSNSLPHSAVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKR 419
Query: 481 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI 540
NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI
Sbjct: 420 NHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLI 479
Query: 541 FLEDCIVTACQEGFICTWGRPGKVVSFNP 569
FLEDCIVTACQEGFICTWGRPGKVVSFNP
Sbjct: 480 FLEDCIVTACQEGFICTWGRPGKVVSFNP 508
>gi|31317276 WD repeat domain 20 isoform 4 [Homo sapiens]
Length = 445
Score = 885 bits (2287), Expect = 0.0
Identities = 426/428 (99%), Positives = 427/428 (99%)
Query: 142 NEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAV 201
+ ERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAV
Sbjct: 18 SHERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAV 77
Query: 202 HTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSY 261
HTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSY
Sbjct: 78 HTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSY 137
Query: 262 FGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEE 321
FGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEE
Sbjct: 138 FGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEE 197
Query: 322 GDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLW 381
GDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLW
Sbjct: 198 GDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLW 257
Query: 382 DLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPRSNSLPHSAVS 441
DLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPRSNSLPHSAVS
Sbjct: 258 DLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPRSNSLPHSAVS 317
Query: 442 NAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSKSSDKLNLVTKT 501
NAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSKSSDKLNLVTKT
Sbjct: 318 NAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSKSSDKLNLVTKT 377
Query: 502 KTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWGRP 561
KTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWGRP
Sbjct: 378 KTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFLEDCIVTACQEGFICTWGRP 437
Query: 562 GKVVSFNP 569
GKVVSFNP
Sbjct: 438 GKVVSFNP 445
>gi|62945417 dystrophia myotonica-containing WD repeat motif protein
[Homo sapiens]
Length = 674
Score = 636 bits (1641), Expect = 0.0
Identities = 341/621 (54%), Positives = 405/621 (65%), Gaps = 77/621 (12%)
Query: 12 EIKTQFTTREGLYKLLPHSEYSR---------------PNRVPFNSQGSNP--------- 47
EIK+QF TREG YKLLP +R P P + S P
Sbjct: 21 EIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSP 80
Query: 48 -------------VRVSFVNLN--DQSG-------------NGDRLCFNVGRELYFY--- 76
VR+S V L D +G GDR+CFN+GRELYFY
Sbjct: 81 PPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGC 140
Query: 77 IYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKE 136
+G +++ DL+KPIDKRIYKGTQPTCHDFN TA E++SLLVGFSAGQVQ +D IKK+
Sbjct: 141 CRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETISLLVGFSAGQVQYLDLIKKD 200
Query: 137 TSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQG 196
TSKLFNEERLIDK++VT +KW+P SESLFL +H+SG++YLYNV H C + P Y LLKQG
Sbjct: 201 TSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYLYNVSHPCASAPPQYSLLKQG 260
Query: 197 ESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHG 256
E F+V+ KSK+ RNPL KW VGEG LNEFAFSPDG+ LACVSQDG LRVF+FDS+ L G
Sbjct: 261 EGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRG 320
Query: 257 TMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYT 316
MKSYFGGLLCVCWSPDG+Y+VTGGEDDLVTVWSF + RV+ARGHGHKSWV+ VAFDPYT
Sbjct: 321 LMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYT 380
Query: 317 TSVEE-----GDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGS 371
T EE G E SG +E+ + A T S S + S+TYRFGS
Sbjct: 381 TRAEEAATAAGADGERSGEEEEEE-------PEAAGTGSAGGAPLSPLPKAGSITYRFGS 433
Query: 372 VGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPR 431
GQDTQ CLWDLTED+L+PH PL+R RT T P A S+ PG +P L R
Sbjct: 434 AGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPG-PLPRSLSR 492
Query: 432 SNSLPHSA-VSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHIS-- 488
SNSLPH A AG + + +FATL+L +R++R EK+HKR HS+G+IS
Sbjct: 493 SNSLPHPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRG 552
Query: 489 ------SKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERLTVLIFL 542
S V +++ DPAK LGT LCPR+ +VPLLEPL+CKKIA ERLTVL+FL
Sbjct: 553 GSGGSGSGGEKPSGPVPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKKIAQERLTVLLFL 612
Query: 543 EDCIVTACQEGFICTWGRPGK 563
EDCI+TACQEG ICTW RPGK
Sbjct: 613 EDCIITACQEGLICTWARPGK 633
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 58.5 bits (140), Expect = 2e-08
Identities = 29/91 (31%), Positives = 50/91 (54%)
Query: 227 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 286
A+SPDGK+LA + DG + +F+ + +L T++ + + + +SPD + +VT +D +
Sbjct: 155 AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYI 214
Query: 287 TVWSFVDCRVIARGHGHKSWVSVVAFDPYTT 317
++ + GH SWV VAF P T
Sbjct: 215 KIYDVQHANLAGTLSGHASWVLNVAFCPDDT 245
Score = 50.4 bits (119), Expect = 4e-06
Identities = 26/103 (25%), Positives = 52/103 (50%), Gaps = 8/103 (7%)
Query: 212 PLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS 271
P+ WT+ AFSPD ++LA + G + +F +S + ++ + +L + +S
Sbjct: 106 PVDAWTL--------AFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYS 157
Query: 272 PDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 314
PDGKY+ +G D ++ ++ +++ GH + + F P
Sbjct: 158 PDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP 200
Score = 48.9 bits (115), Expect = 1e-05
Identities = 20/67 (29%), Positives = 34/67 (50%)
Query: 223 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 282
+ FSPD + L S DG++++++ L GT+ + +L V + PD + V+
Sbjct: 193 IRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSS 252
Query: 283 DDLVTVW 289
D V VW
Sbjct: 253 DKSVKVW 259
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 56.2 bits (134), Expect = 8e-08
Identities = 29/100 (29%), Positives = 54/100 (54%), Gaps = 1/100 (1%)
Query: 222 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 281
A+ AFSP GK+LA S D +R ++ + H T K + +L + WSPDG+ + +G
Sbjct: 116 AVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGC 175
Query: 282 EDDLVTVWSFVDCRVIARG-HGHKSWVSVVAFDPYTTSVE 320
++ + +W + + R GH W++ ++++P + E
Sbjct: 176 KNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215
Score = 55.5 bits (132), Expect = 1e-07
Identities = 48/181 (26%), Positives = 82/181 (45%), Gaps = 21/181 (11%)
Query: 229 SPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTV 288
+P+ +++A S+DG +R+++ + + + + C+ W DG + + +D + V
Sbjct: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKV 271
Query: 289 WSFVD---CRVIARGHGHKSWVSVVAFD-PYTTSVEEGDPMEFSGSDEDFQDLLHFGRDR 344
W D CR + +GHGH WV+ +A Y +P E S + +D Q L ++R
Sbjct: 272 WRAHDGVLCRTL-QGHGH--WVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKER 328
Query: 345 ANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVM 404
A LS+ N + R S D L LW ED +PL+R H ++
Sbjct: 329 A------LSRYNLVRGQGPE---RLVSGSDDFTLFLWSPAED----KKPLTRMTGHQALI 375
Query: 405 N 405
N
Sbjct: 376 N 376
Score = 53.1 bits (126), Expect = 7e-07
Identities = 28/132 (21%), Positives = 59/132 (44%)
Query: 191 QLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFD 250
+L+ + F + + PL + T + +N+ FSPD + +A S D +++++
Sbjct: 343 RLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGR 402
Query: 251 SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVV 310
+ + +++ + + + WS D + +V+G D + VW ++ GH V V
Sbjct: 403 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAV 462
Query: 311 AFDPYTTSVEEG 322
+ P V G
Sbjct: 463 DWSPDGQRVASG 474
Score = 44.7 bits (104), Expect = 2e-04
Identities = 20/68 (29%), Positives = 38/68 (55%)
Query: 222 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 281
A+ + A+S D + L S D L+V++ + +L + + + V WSPDG+ + +GG
Sbjct: 416 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG 475
Query: 282 EDDLVTVW 289
+D + +W
Sbjct: 476 KDKCLRIW 483
Score = 35.0 bits (79), Expect = 0.18
Identities = 15/58 (25%), Positives = 28/58 (48%)
Query: 257 TMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 314
+++ + ++ V +SP GKY+ +G D V W GH+ WV +++ P
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSP 166
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 54.7 bits (130), Expect = 2e-07
Identities = 45/187 (24%), Positives = 75/187 (40%), Gaps = 14/187 (7%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 287
FSP G LA S+D +R++ D K++ + V +S DG+++ T ED +
Sbjct: 68 FSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIK 127
Query: 288 VWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANS 347
VWS R + + H WV F P +G + D+ + + N+
Sbjct: 128 VWSMYRQRFLYSLYRHTHWVRCAKFSP------DGRLIVSCSEDKTIKIWDTTNKQCVNN 181
Query: 348 TQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNAT 407
+ N D P S G D + +WD+ + L H + H+ +N
Sbjct: 182 FSDSVGFANFVDFNPSGTC--IASAGSDQTVKVWDVRVNKLLQHY-----QVHSGGVNCI 234
Query: 408 S-PPAGS 413
S P+G+
Sbjct: 235 SFHPSGN 241
Score = 46.2 bits (108), Expect = 8e-05
Identities = 37/145 (25%), Positives = 61/145 (42%), Gaps = 11/145 (7%)
Query: 221 GALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTG 280
G N F+P G +A D ++V++ +L + + GG+ C+ + P G Y++T
Sbjct: 187 GFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITA 246
Query: 281 GEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLL-- 338
D + + ++ R+I GH V +T S +G + F+ D Q LL
Sbjct: 247 SSDGTLKILDLLEGRLIYTLQGHTGPV-------FTVSFSKGGEL-FASGGADTQVLLWR 298
Query: 339 -HFGRDRANSTQSRLSKRNSTDSRP 362
+F R KR DS P
Sbjct: 299 TNFDELHCKGLTKRNLKRLHFDSPP 323
Score = 45.8 bits (107), Expect = 1e-04
Identities = 25/80 (31%), Positives = 41/80 (51%), Gaps = 1/80 (1%)
Query: 211 NPLLK-WTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVC 269
N LL+ + V G +N +F P G +L S DG L++ + L T++ + G + V
Sbjct: 218 NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVS 277
Query: 270 WSPDGKYIVTGGEDDLVTVW 289
+S G+ +GG D V +W
Sbjct: 278 FSKGGELFASGGADTQVLLW 297
Score = 44.7 bits (104), Expect = 2e-04
Identities = 40/167 (23%), Positives = 70/167 (41%), Gaps = 20/167 (11%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 287
FSPDG+ + S+D +++++ + + G V ++P G I + G D V
Sbjct: 152 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVK 211
Query: 288 VWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANS 347
VW +++ H V+ ++F P G+ + + SD + L +
Sbjct: 212 VWDVRVNKLLQHYQVHSGGVNCISFHP------SGNYLITASSDGTLKIL--------DL 257
Query: 348 TQSRLSKRNSTDSRPV-SVTYR-----FGSVGQDTQLCLWDLTEDIL 388
+ RL + PV +V++ F S G DTQ+ LW D L
Sbjct: 258 LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDEL 304
Score = 32.7 bits (73), Expect = 0.92
Identities = 16/45 (35%), Positives = 23/45 (51%)
Query: 271 SPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPY 315
SP+GK + T D + +W+F R GHK V+ V F P+
Sbjct: 27 SPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 53.1 bits (126), Expect = 7e-07
Identities = 28/132 (21%), Positives = 59/132 (44%)
Query: 191 QLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFD 250
+L+ + F + + PL + T + +N+ FSPD + +A S D +++++
Sbjct: 51 RLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGR 110
Query: 251 SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVV 310
+ + +++ + + + WS D + +V+G D + VW ++ GH V V
Sbjct: 111 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAV 170
Query: 311 AFDPYTTSVEEG 322
+ P V G
Sbjct: 171 DWSPDGQRVASG 182
Score = 44.7 bits (104), Expect = 2e-04
Identities = 20/68 (29%), Positives = 38/68 (55%)
Query: 222 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 281
A+ + A+S D + L S D L+V++ + +L + + + V WSPDG+ + +GG
Sbjct: 124 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG 183
Query: 282 EDDLVTVW 289
+D + +W
Sbjct: 184 KDKCLRIW 191
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 52.8 bits (125), Expect = 9e-07
Identities = 33/109 (30%), Positives = 50/109 (45%), Gaps = 6/109 (5%)
Query: 223 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 282
+N A +P+ K LA SQD +++ +L G + GL CV +SP + + T
Sbjct: 482 INSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASA 541
Query: 283 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSD 331
D + +W+ D + GH + V VAF V G + SGSD
Sbjct: 542 DGTIKLWALQDFSCLKTFEGHDASVLKVAF------VSRGTQLLSSGSD 584
Score = 35.8 bits (81), Expect = 0.11
Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 287
FSP + LA S DG ++++ T + + +L V + G +++ G D LV
Sbjct: 529 FSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVK 588
Query: 288 VWSFV--DCRVIARGHGHKSW 306
+W+ +C H K W
Sbjct: 589 LWTIKNNECVRTLDAHEDKVW 609
Score = 34.7 bits (78), Expect = 0.24
Identities = 17/77 (22%), Positives = 35/77 (45%), Gaps = 2/77 (2%)
Query: 221 GALNEFAFSPDGKFLACVSQ--DGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIV 278
G ++ AF PD L S D +RV++ + +++ + + +S DG ++
Sbjct: 152 GVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTML 211
Query: 279 TGGEDDLVTVWSFVDCR 295
+ G D + +W C+
Sbjct: 212 SSGRDKICIIWDLQSCQ 228
Score = 32.3 bits (72), Expect = 1.2
Identities = 33/110 (30%), Positives = 48/110 (43%), Gaps = 12/110 (10%)
Query: 227 AFSPDGKFLACVSQDGFLRVFNFDSVELHGT--MKSYFGGLLCVCWSPDGKYIV--TGGE 282
AF P LA DG +RV+ D V +GT + G + V + PD ++ +
Sbjct: 116 AFDPTSTLLATGGCDGAVRVW--DIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSAT 173
Query: 283 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDE 332
D + VWS D +A H S V+ +AF +G M SG D+
Sbjct: 174 DAAIRVWSLQDRSCLAVLTAHYSAVTSLAFS------ADGHTMLSSGRDK 217
Score = 29.6 bits (65), Expect = 7.8
Identities = 24/96 (25%), Positives = 37/96 (38%), Gaps = 1/96 (1%)
Query: 223 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKS-YFGGLLCVCWSPDGKYIVTGG 281
+ F SPD + L S+ L + + + K+ + + + + P + TGG
Sbjct: 69 ITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGG 128
Query: 282 EDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTT 317
D V VW V G V +VAF P T
Sbjct: 129 CDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT 164
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 52.0 bits (123), Expect = 1e-06
Identities = 28/101 (27%), Positives = 51/101 (50%), Gaps = 9/101 (8%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMK--------SYFGGLLCVCWSPDGKYIVT 279
FSPDG++L S DGF+ V+NF + ++ +K +LC+C+S D + + T
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 280 GGEDDLVTVWSFVDCRVIAR-GHGHKSWVSVVAFDPYTTSV 319
G +D + VW + + R H V+ ++F ++ +
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQI 322
Score = 36.6 bits (83), Expect = 0.064
Identities = 13/30 (43%), Positives = 20/30 (66%)
Query: 267 CVCWSPDGKYIVTGGEDDLVTVWSFVDCRV 296
C +SPDG+Y+VTG D + VW+F ++
Sbjct: 219 CARFSPDGQYLVTGSVDGFIEVWNFTTGKI 248
Score = 34.7 bits (78), Expect = 0.24
Identities = 18/64 (28%), Positives = 32/64 (50%), Gaps = 3/64 (4%)
Query: 197 ESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHG 256
++ +H KS T L ++ +NE F+ DG ++ S DG ++++N + E
Sbjct: 329 QTIRIHGLKSGKT---LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSN 385
Query: 257 TMKS 260
T KS
Sbjct: 386 TFKS 389
Score = 34.3 bits (77), Expect = 0.32
Identities = 18/63 (28%), Positives = 32/63 (50%)
Query: 227 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 286
A SP G+++ CV +D L F+ + +L T+ + ++ + P I T ED L+
Sbjct: 449 ALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLL 508
Query: 287 TVW 289
+W
Sbjct: 509 KLW 511
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 51.2 bits (121), Expect = 2e-06
Identities = 28/114 (24%), Positives = 55/114 (48%), Gaps = 2/114 (1%)
Query: 211 NPLLKWTVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 268
N LK+T+ A++ FSP+G++LA S D ++++ + T+ + G+ V
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93
Query: 269 CWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 322
WS D +V+ +D + +W + + GH ++V F+P + + G
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147
Score = 45.1 bits (105), Expect = 2e-04
Identities = 24/90 (26%), Positives = 45/90 (50%), Gaps = 3/90 (3%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS---PDGKYIVTGGEDD 284
FSP+GK++ + D L+++++ + T + C+ + GK+IV+G ED+
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281
Query: 285 LVTVWSFVDCRVIARGHGHKSWVSVVAFDP 314
LV +W+ ++ + GH V A P
Sbjct: 282 LVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
Score = 43.1 bits (100), Expect = 7e-04
Identities = 23/91 (25%), Positives = 43/91 (47%)
Query: 223 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 282
+++ A+S D L S D L++++ S + T+K + + C ++P IV+G
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 283 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFD 313
D+ V +W + + H VS V F+
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
Score = 34.3 bits (77), Expect = 0.32
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLC-VCWSPDGKYIVTGGEDDLV 286
F+ DG + S DG R+++ S + T+ + V +SP+GKYI+ D+ +
Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL 238
Query: 287 TVWSFVDCRVIARGHGHKS 305
+W + + + GHK+
Sbjct: 239 KLWDYSKGKCLKTYTGHKN 257
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 51.2 bits (121), Expect = 2e-06
Identities = 28/114 (24%), Positives = 55/114 (48%), Gaps = 2/114 (1%)
Query: 211 NPLLKWTVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 268
N LK+T+ A++ FSP+G++LA S D ++++ + T+ + G+ V
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93
Query: 269 CWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 322
WS D +V+ +D + +W + + GH ++V F+P + + G
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147
Score = 45.1 bits (105), Expect = 2e-04
Identities = 24/90 (26%), Positives = 45/90 (50%), Gaps = 3/90 (3%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS---PDGKYIVTGGEDD 284
FSP+GK++ + D L+++++ + T + C+ + GK+IV+G ED+
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281
Query: 285 LVTVWSFVDCRVIARGHGHKSWVSVVAFDP 314
LV +W+ ++ + GH V A P
Sbjct: 282 LVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
Score = 43.1 bits (100), Expect = 7e-04
Identities = 23/91 (25%), Positives = 43/91 (47%)
Query: 223 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 282
+++ A+S D L S D L++++ S + T+K + + C ++P IV+G
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 283 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFD 313
D+ V +W + + H VS V F+
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
Score = 34.3 bits (77), Expect = 0.32
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLC-VCWSPDGKYIVTGGEDDLV 286
F+ DG + S DG R+++ S + T+ + V +SP+GKYI+ D+ +
Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL 238
Query: 287 TVWSFVDCRVIARGHGHKS 305
+W + + + GHK+
Sbjct: 239 KLWDYSKGKCLKTYTGHKN 257
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 51.2 bits (121), Expect = 2e-06
Identities = 42/146 (28%), Positives = 62/146 (42%), Gaps = 20/146 (13%)
Query: 185 TTAPHYQLLKQGES---FAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 241
T + H+ LL G S + K RN + T ++N FSPD K LA S D
Sbjct: 708 TNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHT---NSVNHCRFSPDDKLLASCSAD 764
Query: 242 GFLRVFNFDSVELHGT--MKSYFGGL-----------LCVCWSPDGKYIVTGGEDDLVTV 288
G L++++ S + +K +F L C WS DG I+ ++ + +
Sbjct: 765 GTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFL 823
Query: 289 WSFVDCRVIARGHGHKSWVSVVAFDP 314
W+ +A GH SWV V F P
Sbjct: 824 WNTDSRSKVADCRGHLSWVHGVMFSP 849
Score = 40.8 bits (94), Expect = 0.003
Identities = 39/164 (23%), Positives = 67/164 (40%), Gaps = 8/164 (4%)
Query: 222 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 281
A+ FS DG+ +A D L+VF ++ E +K++ +LC +S D ++I T
Sbjct: 617 AVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCS 676
Query: 282 EDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFG 341
D V +W+ + ++ H V+ F + + + +GS + F L
Sbjct: 677 VDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL-----LLATGSSDCFLKLWDLN 731
Query: 342 RDRANSTQSRLSKRNSTDSRPVSVTYR-FGSVGQDTQLCLWDLT 384
+ +T NS + S + S D L LWD T
Sbjct: 732 QKECRNTM--FGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
Score = 34.7 bits (78), Expect = 0.24
Identities = 57/261 (21%), Positives = 103/261 (39%), Gaps = 47/261 (18%)
Query: 55 LNDQSGNGDRL------CFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNH 108
+N ++G D L C + L + + A ++ + ++ RI++ H
Sbjct: 906 INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWH 965
Query: 109 LTATAESVSLLVGFSAGQVQL----IDPI-----KKETSKLFNEERLIDKSRV------- 152
+ TA+ +L+ ++Q+ +D +ET K F RL+ SR+
Sbjct: 966 IQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF---RLLKNSRLLSWSFDG 1022
Query: 153 TCVKW--VPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCK--SKS 208
T W + G++ V H G + ++ H K + A T K S
Sbjct: 1023 TVKVWNIITGNKEKDFVCHQ-GTVLSCDISHDA---------TKFSSTSADKTAKIWSFD 1072
Query: 209 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVEL--------HGTMKS 260
PL + G + AFS D LA +G +R++N + EL +
Sbjct: 1073 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1132
Query: 261 YFGGLLCVCWSPDGKYIVTGG 281
+ G + +C+SPDGK +++ G
Sbjct: 1133 HGGWVTDLCFSPDGKMLISAG 1153
Score = 31.2 bits (69), Expect = 2.7
Identities = 20/103 (19%), Positives = 44/103 (42%), Gaps = 8/103 (7%)
Query: 220 EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVT 279
+G + S D + S D ++++FD + ++ + G + C +S D + T
Sbjct: 1042 QGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1101
Query: 280 GGEDDLVTVWSFVD------CRVIAR--GHGHKSWVSVVAFDP 314
G ++ + +W+ + C ++ H WV+ + F P
Sbjct: 1102 GDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP 1144
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 51.2 bits (121), Expect = 2e-06
Identities = 42/146 (28%), Positives = 62/146 (42%), Gaps = 20/146 (13%)
Query: 185 TTAPHYQLLKQGES---FAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 241
T + H+ LL G S + K RN + T ++N FSPD K LA S D
Sbjct: 697 TNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHT---NSVNHCRFSPDDKLLASCSAD 753
Query: 242 GFLRVFNFDSVELHGT--MKSYFGGL-----------LCVCWSPDGKYIVTGGEDDLVTV 288
G L++++ S + +K +F L C WS DG I+ ++ + +
Sbjct: 754 GTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFL 812
Query: 289 WSFVDCRVIARGHGHKSWVSVVAFDP 314
W+ +A GH SWV V F P
Sbjct: 813 WNTDSRSKVADCRGHLSWVHGVMFSP 838
Score = 40.8 bits (94), Expect = 0.003
Identities = 39/164 (23%), Positives = 67/164 (40%), Gaps = 8/164 (4%)
Query: 222 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 281
A+ FS DG+ +A D L+VF ++ E +K++ +LC +S D ++I T
Sbjct: 606 AVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCS 665
Query: 282 EDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFG 341
D V +W+ + ++ H V+ F + + + +GS + F L
Sbjct: 666 VDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL-----LLATGSSDCFLKLWDLN 720
Query: 342 RDRANSTQSRLSKRNSTDSRPVSVTYR-FGSVGQDTQLCLWDLT 384
+ +T NS + S + S D L LWD T
Sbjct: 721 QKECRNTM--FGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
Score = 34.7 bits (78), Expect = 0.24
Identities = 57/261 (21%), Positives = 103/261 (39%), Gaps = 47/261 (18%)
Query: 55 LNDQSGNGDRL------CFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNH 108
+N ++G D L C + L + + A ++ + ++ RI++ H
Sbjct: 895 INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWH 954
Query: 109 LTATAESVSLLVGFSAGQVQL----IDPI-----KKETSKLFNEERLIDKSRV------- 152
+ TA+ +L+ ++Q+ +D +ET K F RL+ SR+
Sbjct: 955 IQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF---RLLKNSRLLSWSFDG 1011
Query: 153 TCVKW--VPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCK--SKS 208
T W + G++ V H G + ++ H K + A T K S
Sbjct: 1012 TVKVWNIITGNKEKDFVCHQ-GTVLSCDISHDA---------TKFSSTSADKTAKIWSFD 1061
Query: 209 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVEL--------HGTMKS 260
PL + G + AFS D LA +G +R++N + EL +
Sbjct: 1062 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1121
Query: 261 YFGGLLCVCWSPDGKYIVTGG 281
+ G + +C+SPDGK +++ G
Sbjct: 1122 HGGWVTDLCFSPDGKMLISAG 1142
Score = 31.2 bits (69), Expect = 2.7
Identities = 20/103 (19%), Positives = 44/103 (42%), Gaps = 8/103 (7%)
Query: 220 EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVT 279
+G + S D + S D ++++FD + ++ + G + C +S D + T
Sbjct: 1031 QGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1090
Query: 280 GGEDDLVTVWSFVD------CRVIAR--GHGHKSWVSVVAFDP 314
G ++ + +W+ + C ++ H WV+ + F P
Sbjct: 1091 GDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSP 1133
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 50.8 bits (120), Expect = 3e-06
Identities = 39/165 (23%), Positives = 67/165 (40%), Gaps = 9/165 (5%)
Query: 223 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 282
+++ S DG+F S DG LR+++ + + +L V +S D + IV+G
Sbjct: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125
Query: 283 DDLVTVWSFVD-CRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFG 341
D + +W+ + C+ + H WVS V F P +P+ S + + +
Sbjct: 126 DKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSP-----NSSNPIIVSCGWDKLVKVWNLA 180
Query: 342 RDRANSTQ-SRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTE 385
+ + N+ P G G+D Q LWDL E
Sbjct: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASG--GKDGQAMLWDLNE 223
Score = 34.7 bits (78), Expect = 0.24
Identities = 42/204 (20%), Positives = 82/204 (40%), Gaps = 34/204 (16%)
Query: 118 LLVGFSAGQVQLIDPIKKETSKLFN-----EERLIDKSR---VTCVKWVPGSESLFLVAH 169
L V FS+ Q++ + +T KL+N + + D+S V+CV++ P S + +V+
Sbjct: 109 LSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSC 168
Query: 170 SSGNMY-LYNVEHTCGTTAPHYQLLKQGESFAVHT----CKSKSTRNPLLKWTVGEGA-- 222
+ ++N+ + C H + V C S + W + EG
Sbjct: 169 GWDKLVKVWNLAN-CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227
Query: 223 --------LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGL--------- 265
+N FSP+ ++ C + +++++ + + +K
Sbjct: 228 YTLDGGDIINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286
Query: 266 LCVCWSPDGKYIVTGGEDDLVTVW 289
+ WS DG+ + G D+LV VW
Sbjct: 287 TSLAWSADGQTLFAGYTDNLVRVW 310
>gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens]
Length = 606
Score = 50.4 bits (119), Expect = 4e-06
Identities = 43/188 (22%), Positives = 85/188 (45%), Gaps = 21/188 (11%)
Query: 121 GFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSS---GNMYLY 177
G +G++++ D +KE L E ++ + W S+ + +V G ++L+
Sbjct: 76 GDVSGKLRIWDTTQKE--HLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLW 133
Query: 178 NVEHTCGTTAPHYQLL-----KQGESFAVHT-----CKSKSTRNPL-LKWTVGEGA--LN 224
+ + G H +++ KQ + + T C + P K+T+G+ + +N
Sbjct: 134 DSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVN 193
Query: 225 EFAFSPDGKFLACVSQDGFLRVFNFDSVE---LHGTMKSYFGGLLCVCWSPDGKYIVTGG 281
FSPDG A S DG + +++ + E G K++ GG+ + WSPD ++++
Sbjct: 194 CVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSAS 253
Query: 282 EDDLVTVW 289
D +W
Sbjct: 254 GDKTSKIW 261
Score = 49.3 bits (116), Expect = 9e-06
Identities = 23/75 (30%), Positives = 39/75 (52%), Gaps = 1/75 (1%)
Query: 220 EGALNEFAFSPDGKFLACVSQDGFLRVFNF-DSVELHGTMKSYFGGLLCVCWSPDGKYIV 278
+G + + A+S DG FLA + VF+ D + + ++C+ WSPD ++
Sbjct: 489 KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFA 548
Query: 279 TGGEDDLVTVWSFVD 293
+GG D +V VW+ D
Sbjct: 549 SGGMDMMVYVWTLSD 563
>gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens]
Length = 466
Score = 49.3 bits (116), Expect = 9e-06
Identities = 23/75 (30%), Positives = 39/75 (52%), Gaps = 1/75 (1%)
Query: 220 EGALNEFAFSPDGKFLACVSQDGFLRVFNF-DSVELHGTMKSYFGGLLCVCWSPDGKYIV 278
+G + + A+S DG FLA + VF+ D + + ++C+ WSPD ++
Sbjct: 349 KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFA 408
Query: 279 TGGEDDLVTVWSFVD 293
+GG D +V VW+ D
Sbjct: 409 SGGMDMMVYVWTLSD 423
Score = 42.7 bits (99), Expect = 9e-04
Identities = 21/70 (30%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 223 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVE---LHGTMKSYFGGLLCVCWSPDGKYIVT 279
+N FSPDG A S DG + +++ + E G K++ GG+ + WSPD ++++
Sbjct: 52 VNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLS 111
Query: 280 GGEDDLVTVW 289
D +W
Sbjct: 112 ASGDKTSKIW 121
>gi|148727341 serine/threonine kinase receptor associated protein
[Homo sapiens]
Length = 350
Score = 48.5 bits (114), Expect = 2e-05
Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 4/101 (3%)
Query: 192 LLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDS 251
++ G S A H+ S +K +N + P+ +FL +D L ++++S
Sbjct: 199 VITYGRSIAFHSAVSLDP----IKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNS 254
Query: 252 VELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFV 292
E + K +FG + CV +SPDG+ +G ED + +W V
Sbjct: 255 GEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTV 295
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 48.1 bits (113), Expect = 2e-05
Identities = 24/87 (27%), Positives = 46/87 (52%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 287
F P G+F+A SQD +++++ + + + C+ +SPDGK++ + +D V
Sbjct: 113 FHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVK 172
Query: 288 VWSFVDCRVIARGHGHKSWVSVVAFDP 314
+W ++++ GH V+VV F P
Sbjct: 173 LWDLTAGKMMSEFPGHTGPVNVVEFHP 199
Score = 39.7 bits (91), Expect = 0.008
Identities = 21/87 (24%), Positives = 42/87 (48%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 287
FSPDGK+LA + D +++++ + ++ + G + V + P+ + +G D +
Sbjct: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIR 214
Query: 288 VWSFVDCRVIARGHGHKSWVSVVAFDP 314
W +V++ G V V F+P
Sbjct: 215 FWDLEKFQVVSCIEGEPGPVRSVLFNP 241
Score = 39.3 bits (90), Expect = 0.010
Identities = 17/76 (22%), Positives = 38/76 (50%)
Query: 239 SQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIA 298
SQ G +RV++ ++ ++ T+ + + + + P G+++ +G +D + +W +
Sbjct: 82 SQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF 141
Query: 299 RGHGHKSWVSVVAFDP 314
R GH V + F P
Sbjct: 142 RYRGHSQAVRCLRFSP 157
Score = 30.0 bits (66), Expect = 5.9
Identities = 34/156 (21%), Positives = 63/156 (40%), Gaps = 14/156 (8%)
Query: 232 GKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSF 291
G+ LA D + +++ + ++ + + V + + IV G + + VW
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
Query: 292 VDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFG---RDRANST 348
+++ GHK+ + + F PY V G ++ D+ G R R +S
Sbjct: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGS----QDTNIKLWDIRRKGCVFRYRGHS- 147
Query: 349 QSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLT 384
Q+ R S D + ++ S D + LWDLT
Sbjct: 148 QAVRCLRFSPDGKWLA------SAADDHTVKLWDLT 177
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 48.1 bits (113), Expect = 2e-05
Identities = 29/102 (28%), Positives = 47/102 (46%)
Query: 221 GALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTG 280
G +N AFSPDG+ L S+DG + + S +L + + G + +SPDG +
Sbjct: 22 GEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASA 81
Query: 281 GEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 322
D V +W + + GH+ V V+F P + + G
Sbjct: 82 SCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASG 123
Score = 47.4 bits (111), Expect = 4e-05
Identities = 30/116 (25%), Positives = 52/116 (44%), Gaps = 2/116 (1%)
Query: 209 TRNPLLKWTVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLL 266
TR+ L W +G G + FSPDG A S D +R+++ + +K + +
Sbjct: 50 TRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVE 109
Query: 267 CVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 322
V +SPD + + +GG D V +W +++ GH+ + F P + G
Sbjct: 110 TVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATG 165
Score = 43.1 bits (100), Expect = 7e-04
Identities = 26/106 (24%), Positives = 49/106 (46%), Gaps = 5/106 (4%)
Query: 213 LLKWTVGE-GALNEFAFSPDGKFLACVSQDGFLRVFNFDSVE---LHGTMKSYFGGLLCV 268
+L+ VG ++ FSP LA S D + +++ V H ++ + + C+
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
Query: 269 CWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 314
C+S G + +G D + +W ++ + GH +WV +AF P
Sbjct: 199 CYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
Score = 33.1 bits (74), Expect = 0.70
Identities = 17/61 (27%), Positives = 31/61 (50%)
Query: 223 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 282
+ AFSPD +LA ++V++ ++ + T+K ++PDGK +V+G
Sbjct: 236 VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAA 295
Query: 283 D 283
D
Sbjct: 296 D 296
>gi|189571685 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 48.1 bits (113), Expect = 2e-05
Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 2/156 (1%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVC-WSPDGKYIVTGGEDDLV 286
FSP G LA S DG ++N ++ ++ M+ G + VC +SPD + +G D V
Sbjct: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
Query: 287 TVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDR-A 345
+W+ ++ G ++ AF P + G +D LH +
Sbjct: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDL 181
Query: 346 NSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLW 381
T S + +D +R S GQD Q+ +W
Sbjct: 182 GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217
Score = 42.0 bits (97), Expect = 0.002
Identities = 35/126 (27%), Positives = 50/126 (39%), Gaps = 23/126 (18%)
Query: 185 TTAPHYQLLKQGESFAVHTC---------KSKSTRNPLLKWTVGEGAL------------ 223
T PH L + ++AVH C S ST + W G +
Sbjct: 43 TELPHSPL--KFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPV 100
Query: 224 NEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGED 283
FSPD LA + DG + ++N S +L+ G L +SP+G + VTG
Sbjct: 101 RVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSC 160
Query: 284 DLVTVW 289
+TVW
Sbjct: 161 GDLTVW 166
Score = 34.3 bits (77), Expect = 0.32
Identities = 28/100 (28%), Positives = 47/100 (47%), Gaps = 7/100 (7%)
Query: 226 FAFSPDGKFLACVSQDGFLRVFNF-DSVEL-HGTMKSYFGGLLCVCWSPDGKYIVTGGED 283
F+FS LA S D +R+++ D EL H +K + + C C+SP G + + D
Sbjct: 20 FSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTD 75
Query: 284 DLVTVWSFVDCRVIA-RGHGHKSWVSVVAFDPYTTSVEEG 322
+W+ + +++A S V V F P +T + G
Sbjct: 76 GTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASG 115
Score = 32.7 bits (73), Expect = 0.92
Identities = 17/65 (26%), Positives = 32/65 (49%)
Query: 227 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 286
AFS DG+ L S D + V++ ++ + T+ + + ++P+ + TG D V
Sbjct: 246 AFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTV 305
Query: 287 TVWSF 291
+W F
Sbjct: 306 NIWQF 310
Score = 30.0 bits (66), Expect = 5.9
Identities = 34/141 (24%), Positives = 60/141 (42%), Gaps = 19/141 (13%)
Query: 217 TVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS----P 272
+V +G+L AFSP+G F S G L V++ D + + K++ G+ C +S
Sbjct: 136 SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194
Query: 273 DGKY------IVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPME 326
DG+ + + G+D V +W ++ +KS +S + M
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254
Query: 327 FSGS--------DEDFQDLLH 339
SGS D + +++LH
Sbjct: 255 VSGSVDKSVIVYDTNTENILH 275
>gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 48.1 bits (113), Expect = 2e-05
Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 2/156 (1%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVC-WSPDGKYIVTGGEDDLV 286
FSP G LA S DG ++N ++ ++ M+ G + VC +SPD + +G D V
Sbjct: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
Query: 287 TVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDR-A 345
+W+ ++ G ++ AF P + G +D LH +
Sbjct: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDL 181
Query: 346 NSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLW 381
T S + +D +R S GQD Q+ +W
Sbjct: 182 GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217
Score = 42.0 bits (97), Expect = 0.002
Identities = 35/126 (27%), Positives = 50/126 (39%), Gaps = 23/126 (18%)
Query: 185 TTAPHYQLLKQGESFAVHTC---------KSKSTRNPLLKWTVGEGAL------------ 223
T PH L + ++AVH C S ST + W G +
Sbjct: 43 TELPHSPL--KFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPV 100
Query: 224 NEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGED 283
FSPD LA + DG + ++N S +L+ G L +SP+G + VTG
Sbjct: 101 RVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSC 160
Query: 284 DLVTVW 289
+TVW
Sbjct: 161 GDLTVW 166
Score = 34.3 bits (77), Expect = 0.32
Identities = 28/100 (28%), Positives = 47/100 (47%), Gaps = 7/100 (7%)
Query: 226 FAFSPDGKFLACVSQDGFLRVFNF-DSVEL-HGTMKSYFGGLLCVCWSPDGKYIVTGGED 283
F+FS LA S D +R+++ D EL H +K + + C C+SP G + + D
Sbjct: 20 FSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTD 75
Query: 284 DLVTVWSFVDCRVIA-RGHGHKSWVSVVAFDPYTTSVEEG 322
+W+ + +++A S V V F P +T + G
Sbjct: 76 GTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASG 115
Score = 32.7 bits (73), Expect = 0.92
Identities = 17/65 (26%), Positives = 32/65 (49%)
Query: 227 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 286
AFS DG+ L S D + V++ ++ + T+ + + ++P+ + TG D V
Sbjct: 246 AFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTV 305
Query: 287 TVWSF 291
+W F
Sbjct: 306 NIWQF 310
Score = 30.0 bits (66), Expect = 5.9
Identities = 34/141 (24%), Positives = 60/141 (42%), Gaps = 19/141 (13%)
Query: 217 TVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS----P 272
+V +G+L AFSP+G F S G L V++ D + + K++ G+ C +S
Sbjct: 136 SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194
Query: 273 DGKY------IVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPME 326
DG+ + + G+D V +W ++ +KS +S + M
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254
Query: 327 FSGS--------DEDFQDLLH 339
SGS D + +++LH
Sbjct: 255 VSGSVDKSVIVYDTNTENILH 275
>gi|189571681 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 48.1 bits (113), Expect = 2e-05
Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 2/156 (1%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVC-WSPDGKYIVTGGEDDLV 286
FSP G LA S DG ++N ++ ++ M+ G + VC +SPD + +G D V
Sbjct: 62 FSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
Query: 287 TVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDR-A 345
+W+ ++ G ++ AF P + G +D LH +
Sbjct: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDL 181
Query: 346 NSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLW 381
T S + +D +R S GQD Q+ +W
Sbjct: 182 GITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIW 217
Score = 42.0 bits (97), Expect = 0.002
Identities = 35/126 (27%), Positives = 50/126 (39%), Gaps = 23/126 (18%)
Query: 185 TTAPHYQLLKQGESFAVHTC---------KSKSTRNPLLKWTVGEGAL------------ 223
T PH L + ++AVH C S ST + W G +
Sbjct: 43 TELPHSPL--KFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPV 100
Query: 224 NEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGED 283
FSPD LA + DG + ++N S +L+ G L +SP+G + VTG
Sbjct: 101 RVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSC 160
Query: 284 DLVTVW 289
+TVW
Sbjct: 161 GDLTVW 166
Score = 34.3 bits (77), Expect = 0.32
Identities = 28/100 (28%), Positives = 47/100 (47%), Gaps = 7/100 (7%)
Query: 226 FAFSPDGKFLACVSQDGFLRVFNF-DSVEL-HGTMKSYFGGLLCVCWSPDGKYIVTGGED 283
F+FS LA S D +R+++ D EL H +K + + C C+SP G + + D
Sbjct: 20 FSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTD 75
Query: 284 DLVTVWSFVDCRVIA-RGHGHKSWVSVVAFDPYTTSVEEG 322
+W+ + +++A S V V F P +T + G
Sbjct: 76 GTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASG 115
Score = 32.7 bits (73), Expect = 0.92
Identities = 17/65 (26%), Positives = 32/65 (49%)
Query: 227 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 286
AFS DG+ L S D + V++ ++ + T+ + + ++P+ + TG D V
Sbjct: 246 AFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTV 305
Query: 287 TVWSF 291
+W F
Sbjct: 306 NIWQF 310
Score = 30.0 bits (66), Expect = 5.9
Identities = 34/141 (24%), Positives = 60/141 (42%), Gaps = 19/141 (13%)
Query: 217 TVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS----P 272
+V +G+L AFSP+G F S G L V++ D + + K++ G+ C +S
Sbjct: 136 SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194
Query: 273 DGKY------IVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPME 326
DG+ + + G+D V +W ++ +KS +S + M
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254
Query: 327 FSGS--------DEDFQDLLH 339
SGS D + +++LH
Sbjct: 255 VSGSVDKSVIVYDTNTENILH 275
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 47.4 bits (111), Expect = 4e-05
Identities = 31/123 (25%), Positives = 53/123 (43%)
Query: 183 CGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDG 242
C P+ L G + S N + +T G + AFSP+GK+LA +D
Sbjct: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490
Query: 243 FLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHG 302
L++++ S L+ ++ + + + +SPD I + D+ V VW + A G
Sbjct: 491 RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADG 550
Query: 303 HKS 305
S
Sbjct: 551 SSS 553
Score = 45.1 bits (105), Expect = 2e-04
Identities = 22/87 (25%), Positives = 41/87 (47%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 287
F P+ +LA S D +R+++ + G +L + +SP+GKY+ + GED +
Sbjct: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLK 493
Query: 288 VWSFVDCRVIARGHGHKSWVSVVAFDP 314
+W + GH ++ + F P
Sbjct: 494 LWDLASGTLYKELRGHTDNITSLTFSP 520
Score = 40.8 bits (94), Expect = 0.003
Identities = 24/86 (27%), Positives = 37/86 (43%)
Query: 229 SPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTV 288
SP + A S D R+++FD + + CV + P+ Y+ TG D V +
Sbjct: 393 SPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRL 452
Query: 289 WSFVDCRVIARGHGHKSWVSVVAFDP 314
WS + GH+ V +AF P
Sbjct: 453 WSAQQGNSVRLFTGHRGPVLSLAFSP 478
Score = 36.6 bits (83), Expect = 0.064
Identities = 49/199 (24%), Positives = 75/199 (37%), Gaps = 25/199 (12%)
Query: 221 GALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCW----SPDGKY 276
G + F D L S+D +R ++ S T + G W SP Y
Sbjct: 343 GPVYSTRFLADSSGLLSCSEDMSIRYWDLGSF----TNTVLYQGHAYPVWDLDISPYSLY 398
Query: 277 IVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQD 336
+G D +WSF + GH + V V F P + + G +D+ +
Sbjct: 399 FASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGS------TDKTVR- 451
Query: 337 LLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRF-GSVGQDTQLCLWDLTEDILFPHQPLS 395
+ + NS + R S S ++ S G+D +L LWDL L+
Sbjct: 452 --LWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLY-----K 504
Query: 396 RARTHT-NVMNAT-SPPAG 412
R HT N+ + T SP +G
Sbjct: 505 ELRGHTDNITSLTFSPDSG 523
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 46.6 bits (109), Expect = 6e-05
Identities = 24/81 (29%), Positives = 38/81 (46%)
Query: 209 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 268
T L + + A+N +F P G +L S D L++ + L T+ + G V
Sbjct: 180 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 239
Query: 269 CWSPDGKYIVTGGEDDLVTVW 289
+S G+Y +GG D+ V VW
Sbjct: 240 AFSRTGEYFASGGSDEQVMVW 260
Score = 44.3 bits (103), Expect = 3e-04
Identities = 31/150 (20%), Positives = 60/150 (40%), Gaps = 6/150 (4%)
Query: 183 CGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDG 242
C +P +L+ KS+R + + G + F P G +A D
Sbjct: 112 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 171
Query: 243 FLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHG 302
++V++ + L + + + + + P G Y++T D + + ++ R++ HG
Sbjct: 172 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG 231
Query: 303 HKSWVSVVAFDPYTTSVEEGDPMEFSGSDE 332
H+ + VAF G+ GSDE
Sbjct: 232 HQGPATTVAFS------RTGEYFASGGSDE 255
Score = 39.7 bits (91), Expect = 0.008
Identities = 28/138 (20%), Positives = 51/138 (36%)
Query: 182 TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 241
TC +P LL G + + + + F DG+ S D
Sbjct: 27 TCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDD 86
Query: 242 GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH 301
++V+ + ++ + + C +SPDG+ IV+ +D V +W +
Sbjct: 87 KTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 146
Query: 302 GHKSWVSVVAFDPYTTSV 319
H +V+ V F P T +
Sbjct: 147 EHGGFVTYVDFHPSGTCI 164
Score = 37.7 bits (86), Expect = 0.029
Identities = 39/183 (21%), Positives = 70/183 (38%), Gaps = 8/183 (4%)
Query: 215 KWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDG 274
++T + A+ FSP G LA S+D +R++ + +++ + V + DG
Sbjct: 18 RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 77
Query: 275 KYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDF 334
+ VT +D V VW+ + + H +WV F P +G + + D+
Sbjct: 78 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP------DGRLIVSASDDKTV 131
Query: 335 QDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPL 394
+ R+ +S D P + G D + +WD+ L H L
Sbjct: 132 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC--IAAAGMDNTVKVWDVRTHRLLQHYQL 189
Query: 395 SRA 397
A
Sbjct: 190 HSA 192
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 46.6 bits (109), Expect = 6e-05
Identities = 24/81 (29%), Positives = 38/81 (46%)
Query: 209 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 268
T L + + A+N +F P G +L S D L++ + L T+ + G V
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277
Query: 269 CWSPDGKYIVTGGEDDLVTVW 289
+S G+Y +GG D+ V VW
Sbjct: 278 AFSRTGEYFASGGSDEQVMVW 298
Score = 44.3 bits (103), Expect = 3e-04
Identities = 31/150 (20%), Positives = 60/150 (40%), Gaps = 6/150 (4%)
Query: 183 CGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDG 242
C +P +L+ KS+R + + G + F P G +A D
Sbjct: 150 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 209
Query: 243 FLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHG 302
++V++ + L + + + + + P G Y++T D + + ++ R++ HG
Sbjct: 210 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG 269
Query: 303 HKSWVSVVAFDPYTTSVEEGDPMEFSGSDE 332
H+ + VAF G+ GSDE
Sbjct: 270 HQGPATTVAFS------RTGEYFASGGSDE 293
Score = 39.7 bits (91), Expect = 0.008
Identities = 28/138 (20%), Positives = 51/138 (36%)
Query: 182 TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 241
TC +P LL G + + + + F DG+ S D
Sbjct: 65 TCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDD 124
Query: 242 GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH 301
++V+ + ++ + + C +SPDG+ IV+ +D V +W +
Sbjct: 125 KTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 184
Query: 302 GHKSWVSVVAFDPYTTSV 319
H +V+ V F P T +
Sbjct: 185 EHGGFVTYVDFHPSGTCI 202
Score = 37.7 bits (86), Expect = 0.029
Identities = 39/183 (21%), Positives = 70/183 (38%), Gaps = 8/183 (4%)
Query: 215 KWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDG 274
++T + A+ FSP G LA S+D +R++ + +++ + V + DG
Sbjct: 56 RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 115
Query: 275 KYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDF 334
+ VT +D V VW+ + + H +WV F P +G + + D+
Sbjct: 116 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP------DGRLIVSASDDKTV 169
Query: 335 QDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPL 394
+ R+ +S D P + G D + +WD+ L H L
Sbjct: 170 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC--IAAAGMDNTVKVWDVRTHRLLQHYQL 227
Query: 395 SRA 397
A
Sbjct: 228 HSA 230
Score = 31.6 bits (70), Expect = 2.0
Identities = 18/62 (29%), Positives = 27/62 (43%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 287
FS + K LA S D L V++ + + CV +SP G + +G D V
Sbjct: 27 FSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVR 86
Query: 288 VW 289
+W
Sbjct: 87 IW 88
Score = 31.2 bits (69), Expect = 2.7
Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 2/64 (3%)
Query: 251 SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVV 310
S+E H K + + CV +S + K + +G D + VW R GHK V+ V
Sbjct: 10 SLERH--FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCV 67
Query: 311 AFDP 314
F P
Sbjct: 68 NFSP 71
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 46.6 bits (109), Expect = 6e-05
Identities = 24/81 (29%), Positives = 38/81 (46%)
Query: 209 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 268
T L + + A+N +F P G +L S D L++ + L T+ + G V
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 277
Query: 269 CWSPDGKYIVTGGEDDLVTVW 289
+S G+Y +GG D+ V VW
Sbjct: 278 AFSRTGEYFASGGSDEQVMVW 298
Score = 44.3 bits (103), Expect = 3e-04
Identities = 31/150 (20%), Positives = 60/150 (40%), Gaps = 6/150 (4%)
Query: 183 CGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDG 242
C +P +L+ KS+R + + G + F P G +A D
Sbjct: 150 CAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 209
Query: 243 FLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHG 302
++V++ + L + + + + + P G Y++T D + + ++ R++ HG
Sbjct: 210 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG 269
Query: 303 HKSWVSVVAFDPYTTSVEEGDPMEFSGSDE 332
H+ + VAF G+ GSDE
Sbjct: 270 HQGPATTVAFS------RTGEYFASGGSDE 293
Score = 39.7 bits (91), Expect = 0.008
Identities = 28/138 (20%), Positives = 51/138 (36%)
Query: 182 TCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQD 241
TC +P LL G + + + + F DG+ S D
Sbjct: 65 TCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDD 124
Query: 242 GFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGH 301
++V+ + ++ + + C +SPDG+ IV+ +D V +W +
Sbjct: 125 KTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 184
Query: 302 GHKSWVSVVAFDPYTTSV 319
H +V+ V F P T +
Sbjct: 185 EHGGFVTYVDFHPSGTCI 202
Score = 37.7 bits (86), Expect = 0.029
Identities = 39/183 (21%), Positives = 70/183 (38%), Gaps = 8/183 (4%)
Query: 215 KWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDG 274
++T + A+ FSP G LA S+D +R++ + +++ + V + DG
Sbjct: 56 RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 115
Query: 275 KYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDF 334
+ VT +D V VW+ + + H +WV F P +G + + D+
Sbjct: 116 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP------DGRLIVSASDDKTV 169
Query: 335 QDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPL 394
+ R+ +S D P + G D + +WD+ L H L
Sbjct: 170 KLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC--IAAAGMDNTVKVWDVRTHRLLQHYQL 227
Query: 395 SRA 397
A
Sbjct: 228 HSA 230
Score = 31.6 bits (70), Expect = 2.0
Identities = 18/62 (29%), Positives = 27/62 (43%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 287
FS + K LA S D L V++ + + CV +SP G + +G D V
Sbjct: 27 FSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVR 86
Query: 288 VW 289
+W
Sbjct: 87 IW 88
Score = 31.2 bits (69), Expect = 2.7
Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 2/64 (3%)
Query: 251 SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVV 310
S+E H K + + CV +S + K + +G D + VW R GHK V+ V
Sbjct: 10 SLERH--FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCV 67
Query: 311 AFDP 314
F P
Sbjct: 68 NFSP 71
>gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]
Length = 919
Score = 46.6 bits (109), Expect = 6e-05
Identities = 45/189 (23%), Positives = 78/189 (41%), Gaps = 7/189 (3%)
Query: 131 DPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLF-LVAHSSGNMYLYNVEH-----TCG 184
D +++E + E++ D+ K P E V +S Y +N E T
Sbjct: 235 DLLQREEEEEEEEDQEGDRETTIRGKATPAEEEKTGKVKYSRLAKYFFNKEGDFNNLTAA 294
Query: 185 TTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLAC-VSQDGF 243
LL G + + N + ++ + ++ A + G ++A S G
Sbjct: 295 AFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQ 354
Query: 244 LRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGH 303
L V+ + S + +F ++ + +SPDG+YIVTGG+D V VW+ + H
Sbjct: 355 LLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEH 414
Query: 304 KSWVSVVAF 312
S V+ V F
Sbjct: 415 SSGVTGVTF 423
Score = 32.7 bits (73), Expect = 0.92
Identities = 18/60 (30%), Positives = 30/60 (50%)
Query: 227 AFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 286
A+SPDG+++ DG ++V+N S T + G+ V ++ G +VT D V
Sbjct: 380 AYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTV 439
Score = 30.8 bits (68), Expect = 3.5
Identities = 23/89 (25%), Positives = 37/89 (41%), Gaps = 2/89 (2%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLL-CVCWSPDGKYIVTGGEDDL- 285
F+ G + S DG +R F+ T S CV G+ + G +D
Sbjct: 423 FTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFE 482
Query: 286 VTVWSFVDCRVIARGHGHKSWVSVVAFDP 314
+ VWS R++ GH+ +S + F+P
Sbjct: 483 IFVWSMQTGRLLDVLSGHEGPISGLCFNP 511
Score = 30.4 bits (67), Expect = 4.6
Identities = 22/83 (26%), Positives = 38/83 (45%), Gaps = 18/83 (21%)
Query: 220 EGALNEFAFSPDGKFLACVSQD--------GFLRVFNFDSVELHGTMKSYFGGL---LCV 268
+G+++ +FSPDG+ + G R FN ++ K+YFG C+
Sbjct: 96 KGSVHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLD-----KTYFGPYDETTCI 150
Query: 269 CWSPDGKYIVTGGEDDLVTVWSF 291
W+ D + V G +D ++ W F
Sbjct: 151 DWTDDSRCFVVGSKD--MSTWVF 171
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 46.2 bits (108), Expect = 8e-05
Identities = 23/89 (25%), Positives = 42/89 (47%)
Query: 222 ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG 281
++ + +F GK LA S D +++++F E TM + + V P+G +IV+
Sbjct: 152 SVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSAS 211
Query: 282 EDDLVTVWSFVDCRVIARGHGHKSWVSVV 310
D + +W + GH+ WV +V
Sbjct: 212 RDKTIKMWEVQTGYCVKTFTGHREWVRMV 240
Score = 41.2 bits (95), Expect = 0.003
Identities = 21/87 (24%), Positives = 40/87 (45%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 287
F P + S+D ++V+++++ + T+K + + + + GK + + D +
Sbjct: 116 FHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIK 175
Query: 288 VWSFVDCRVIARGHGHKSWVSVVAFDP 314
+W F I HGH VS VA P
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMP 202
Score = 34.7 bits (78), Expect = 0.24
Identities = 21/102 (20%), Positives = 40/102 (39%), Gaps = 20/102 (19%)
Query: 231 DGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPD----------------- 273
DG +A S D +RV+ + E ++ + + C+ W+P+
Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304
Query: 274 ---GKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAF 312
G ++++G D + +W + GH +WV V F
Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLF 346
Score = 34.3 bits (77), Expect = 0.32
Identities = 19/68 (27%), Positives = 33/68 (48%), Gaps = 3/68 (4%)
Query: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 287
F GKF+ + D LRV+++ + T+ ++ + + + Y+VTG D V
Sbjct: 346 FHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVK 405
Query: 288 VWSFVDCR 295
VW +CR
Sbjct: 406 VW---ECR 410
Score = 30.0 bits (66), Expect = 5.9
Identities = 22/95 (23%), Positives = 48/95 (50%), Gaps = 5/95 (5%)
Query: 232 GKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSF 291
G FL S+D +++++ + T+ + + V + GK+I++ +D + VW +
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 292 VDCRVIARGHGHKSWVSVVAFD---PY--TTSVEE 321
+ R + + H+ +V+ + F PY T SV++
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQ 402
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,546,062
Number of Sequences: 37866
Number of extensions: 1101063
Number of successful extensions: 5115
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 154
Number of HSP's successfully gapped in prelim test: 112
Number of HSP's that attempted gapping in prelim test: 4090
Number of HSP's gapped (non-prelim): 941
length of query: 569
length of database: 18,247,518
effective HSP length: 108
effective length of query: 461
effective length of database: 14,157,990
effective search space: 6526833390
effective search space used: 6526833390
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.