Search of human proteins with 30425444

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
         (765 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...  1540   0.0  
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    434   e-121
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        242   8e-64
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       235   1e-61
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        235   1e-61
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        235   1e-61
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        235   1e-61
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        235   1e-61
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       233   5e-61
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        233   5e-61
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        233   5e-61
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          194   3e-49
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   194   3e-49
gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo ...   189   6e-48
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  187   4e-47
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   185   1e-46
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   177   4e-44
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   166   8e-41
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   161   2e-39
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   160   3e-39
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   160   3e-39
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   158   2e-38
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    158   2e-38
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   154   3e-37
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   154   3e-37
gi|34304381 inversin isoform a [Homo sapiens]                         154   4e-37
gi|34304379 inversin isoform b [Homo sapiens]                         154   4e-37
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   150   4e-36
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...   150   6e-36
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]            144   3e-34

>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 1540 bits (3986), Expect = 0.0
 Identities = 765/765 (100%), Positives = 765/765 (100%)

Query: 1   MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDA 60
           MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDA
Sbjct: 1   MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDA 60

Query: 61  ASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPLGIVMEFMANGSLEKVLSTHSLCWKLR 120
           ASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPLGIVMEFMANGSLEKVLSTHSLCWKLR
Sbjct: 61  ASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPLGIVMEFMANGSLEKVLSTHSLCWKLR 120

Query: 121 FRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIE 180
           FRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIE
Sbjct: 121 FRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIE 180

Query: 181 RSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIIIRVAA 240
           RSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIIIRVAA
Sbjct: 181 RSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIIIRVAA 240

Query: 241 GMRPSLQPVSDQWPSEAQQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQSRVAVPE 300
           GMRPSLQPVSDQWPSEAQQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQSRVAVPE
Sbjct: 241 GMRPSLQPVSDQWPSEAQQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQSRVAVPE 300

Query: 301 SKALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYE 360
           SKALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYE
Sbjct: 301 SKALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYE 360

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
           ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
           VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
           RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
           AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW
Sbjct: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV
Sbjct: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720

Query: 721 QDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGSKPGAEMEI 765
           QDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGSKPGAEMEI
Sbjct: 721 QDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGSKPGAEMEI 765


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  434 bits (1115), Expect = e-121
 Identities = 280/767 (36%), Positives = 398/767 (51%), Gaps = 91/767 (11%)

Query: 6   TELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASSDV 65
           T   L  L  F   +F G W  V SGGF QV++ RH  W+T  AIKC+P L  D    + 
Sbjct: 7   TPWALALLRTFDAGEFTG-WEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVD--DRER 63

Query: 66  NYLIEEAAKMKKIKFQHIVSIYGVCKQPLGIVMEFMANGSLEKVLSTHSLCWKLRFRIIH 125
             L+EEA KM+  KF++I+ +YG+C++P+G+VME+M  GSLEK+L++  L W LRFRIIH
Sbjct: 64  MELLEEAKKMEMAKFRYILPVYGICREPVGLVMEYMETGSLEKLLASEPLPWDLRFRIIH 123

Query: 126 ETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSALR 185
           ET++ MNFLH + PPLLHLDLKP NILLD++ HVKISDFGL+K     +    +    L 
Sbjct: 124 ETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAK-CNGLSHSHDLSMDGLF 182

Query: 186 GMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSG-FNMMMIIIRVAAGMRP 244
           G ++Y+PPE   E ++    K+DVYSFAIVIW +LTQKKP++   N++ I+++V  G RP
Sbjct: 183 GTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRP 242

Query: 245 SLQPVSDQWPSEAQQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQSRV-------- 296
            L PV    P     ++ LM+RCW  DP+ RP F +IT ET+ L       V        
Sbjct: 243 ELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQEITSETEDLCEKPDDEVKETAHDLD 302

Query: 297 ----AVPESKALARKV-----------------------SCKLSLRQPGEVNEDISQ-EL 328
                 P S+ +  ++                           ++  P E++   S+ +L
Sbjct: 303 VKSPPEPRSEVVPARLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPEELSRSSSESKL 362

Query: 329 MDSDSGNYL------------KRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVE 376
             S SG  L            + +L LS  +   P   +L   + +   L   +  G   
Sbjct: 363 PSSGSGKRLSGVSSVDSAFSSRGSLSLSFERE--PSTSDLGTTDVQKKKLVDAIVSGDTS 420

Query: 377 QVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD---------------- 420
           ++  +L  + DVD    SG + L +A +  Q +    LL + A+                
Sbjct: 421 KLMKILQPQ-DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479

Query: 421 -----------------ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWT 463
                             N  DED W  LHFAAQNGD+ + RLLL+  A V+  + EG T
Sbjct: 480 ERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRT 539

Query: 464 PLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQ-GAELDA 522
           P+H+A Q+  EN+ R+L+ R  D +L   +   PLH AA+ GH+ +VKLL  Q G  ++A
Sbjct: 540 PMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNA 599

Query: 523 QQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRY 582
           Q  + RTPLHLA +RG  R  + L+   +  +        PLH AA  G     ++LL  
Sbjct: 600 QTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHR 659

Query: 583 GASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVV 642
           GA  E  T  G+T LHLAA  GHL  + LL E  A++ A G +N T LHLAA HG   VV
Sbjct: 660 GAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVV 719

Query: 643 SALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN 689
             L+      +  ++ G + LHLA Q     +V  LL H A+++ ++
Sbjct: 720 EELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQS 765



 Score =  117 bits (292), Expect = 5e-26
 Identities = 85/272 (31%), Positives = 127/272 (46%), Gaps = 3/272 (1%)

Query: 486 DPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQH 545
           D +L    G + LH+A   G     K L    A  +   R   TPLH+AVER +VR +  
Sbjct: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVER-RVRGVVE 488

Query: 546 LLKSGAVP-DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKG 604
           LL +  +  +A D+  +  LH AA  G     ++LL   AS+     +G TP+H+A   G
Sbjct: 489 LLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHG 548

Query: 605 HLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALL-QCGADPNAAEQSGWTPL 663
              I+ +L     ++   G   W PLH AA  G   +V  L  Q G   NA    G TPL
Sbjct: 549 QENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPL 608

Query: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723
           HLA QR  +     L++  ++V+  + +  TP H+AA  G+T+  ++L+  GA  +    
Sbjct: 609 HLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTS 668

Query: 724 VSCTPLQLALRSRKQGIMSFLEGKEPSVATLG 755
              T L LA R+     +  L  ++  V   G
Sbjct: 669 DGYTALHLAARNGHLATVKLLVEEKADVLARG 700



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 71/220 (32%), Positives = 103/220 (46%), Gaps = 6/220 (2%)

Query: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
           TS     D Q++ L      A+  G    +  +L+   V  ALD SG   LH A   G+ 
Sbjct: 397 TSDLGTTDVQKKKLVD----AIVSGDTSKLMKILQPQDVDLALD-SGASLLHLAVEAGQE 451

Query: 574 LICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633
              K LL   A+  L   +G TPLH+A  +    ++ LL     ++ A     WT LH A
Sbjct: 452 ECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFA 511

Query: 634 ARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGW 693
           A++G+E+    LL+  A  N  +  G TP+H+A Q      V  LL    +V  + K  W
Sbjct: 512 AQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAW 571

Query: 694 TPAHLAALKGNTAILKVLV-EAGAQLDVQDGVSCTPLQLA 732
            P H AA +G+  I+K+L  + G  ++ Q     TPL LA
Sbjct: 572 LPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 611


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  242 bits (618), Expect = 8e-64
 Identities = 142/402 (35%), Positives = 215/402 (53%), Gaps = 2/402 (0%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N ++PLH       +  V+LLL H V VD  T    T L +AA      +  +LL   A
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
           + N    +G+ PLH A +        LLL HGA + A    G TP+H+AA     N+   
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQ 451

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+   A PN     G+T LH+AA  G   +V+ L   GA+++A+ ++ +TPLH++   GK
Sbjct: 452 LMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGK 511

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
              +Q LL+ GA P+A   SGY PLH +A  G   +   LL +GASL + T +G+TPLH+
Sbjct: 512 ADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHV 571

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  G LE+ +LL +  A+  A G    TPLH+AA +  + V   LL  GA P+AA ++G
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH+A +++       LLE+ A+ +A  + G    HLAA +G+  ++ +L+   A ++
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691

Query: 720 VQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
           + +    TPL LA +  +  +   L  +G      T  G  P
Sbjct: 692 LSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTP 733



 Score =  229 bits (583), Expect = 9e-60
 Identities = 145/450 (32%), Positives = 232/450 (51%), Gaps = 11/450 (2%)

Query: 321 NEDISQELMDSDS-GNYLKRALQLSDRKN------LVPRDEELCIYENK--VTPLHFLVA 371
           ++ +   L+++D+ G     AL ++ RK+      L+ +++     E+K   TPLH    
Sbjct: 185 HDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAH 244

Query: 372 QGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431
            G++    LLL     VD    +  TPL +A++    ++  LLL  GA  +    DG  P
Sbjct: 245 YGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTP 304

Query: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491
           LH  A++G +    +LLD  A + ++ + G +PLH+A Q +  N  +LL+      +   
Sbjct: 305 LHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT 364

Query: 492 AEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGA 551
            +  T LHVAA+ GH  + K+L  + A  +A+  N  TPLH+A ++ +++ ++ LLK GA
Sbjct: 365 NDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGA 424

Query: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611
              A+ +SG  P+H AA  G   I   L+ +GAS      +G T LH+AA  G  E++  
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484

Query: 612 LAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRST 671
           L +  A + A    + TPLH++AR G+  +V  LLQ GA PNAA  SG+TPLHL+ +   
Sbjct: 485 LVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGH 544

Query: 672 FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731
                 LL+H A++    K G+TP H+AA  G   +  +L++  A  D       TPL +
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604

Query: 732 ALR--SRKQGIMSFLEGKEPSVATLGGSKP 759
           A    ++K  ++   +G  P  A   G  P
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTP 634



 Score =  222 bits (565), Expect = 1e-57
 Identities = 135/399 (33%), Positives = 204/399 (51%), Gaps = 2/399 (0%)

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           N  TPLH    +  ++ + LLL H   +   T SG TP+ +AA     ++ + L+ HGA 
Sbjct: 399 NGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS 458

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
            N  +  G   LH AA++G     R L+  GA V+A+ ++  TPLH++A+    ++ + L
Sbjct: 459 PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQL 518

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
           + + A PN     G TPLH++A  GH  +   L   GA L    +   TPLH+A + GK+
Sbjct: 519 LQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKL 578

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
                LL+  A PDA  +SG  PLH AA      +  +LL  GAS       G+TPLH+A
Sbjct: 579 EVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
           A K  ++I   L E  A+  A+       +HLAA+ G   +VS LL   A+ N + +SG 
Sbjct: 639 AKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL 698

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLHLA Q         L+   A+V A+ K+G+TP H+    GN  I+  L++  A+++ 
Sbjct: 699 TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758

Query: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGS 757
           +     TPL  A +     I++ L      P+  T+ G+
Sbjct: 759 KTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN 797



 Score =  218 bits (556), Expect = 1e-56
 Identities = 129/359 (35%), Positives = 188/359 (52%)

Query: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
           + E+ +TP+H     G V  V  L+ H    +     G T L +AA+  Q ++   L+  
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488

Query: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477
           GA      +D   PLH +A+ G     + LL  GA  +A    G+TPLHL+A+   E+VA
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548

Query: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537
             L+   A  ++   +G TPLHVAA +G + +  LL  + A  DA  ++  TPLH+A   
Sbjct: 549 AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHY 608

Query: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597
              +    LL  GA P A  ++GY PLH AA + +  I   LL YGA     T QG   +
Sbjct: 609 DNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASV 668

Query: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657
           HLAA +GH++++ LL   +AN+        TPLHLAA+     V   L+  GA  +A  +
Sbjct: 669 HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 728

Query: 658 SGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA 716
            G+TPLH+         V  LL+H A V+A+ K G+TP H AA +G+T I+ VL++  A
Sbjct: 729 MGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNA 787



 Score =  210 bits (535), Expect = 3e-54
 Identities = 147/475 (30%), Positives = 231/475 (48%), Gaps = 40/475 (8%)

Query: 299 PESKALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCI 358
           PE K   RK S      +  +   D +   + +    +L++AL     KN V  D  +C 
Sbjct: 22  PEKKRKHRKRS------RDRKKKSDANASYLRAARAGHLEKALDYI--KNGV--DINIC- 70

Query: 359 YENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHG 418
            +N +  LH    +G VE V  LL  E +VD  T  G T L IA+   Q ++  +L+ +G
Sbjct: 71  NQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNG 130

Query: 419 ADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTP-------------- 464
           A+ N   ++G+ PL+ AAQ       + LLD+GA       +G+TP              
Sbjct: 131 ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190

Query: 465 ---------------LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSL 509
                          LH+AA+ +    A LL+    + ++    G TPLH+AA++G++++
Sbjct: 191 LLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINV 250

Query: 510 VKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAA 569
             LL ++ A +D   RN  TPLH+A +RG    ++ LL  GA  DA  + G  PLH  A 
Sbjct: 251 ATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGAR 310

Query: 570 RGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTP 629
            G   + +MLL   A +   T  G +PLH+A    HL  + LL + +  +  +     T 
Sbjct: 311 SGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTA 370

Query: 630 LHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN 689
           LH+AA  G   V   LL   A+PNA   +G+TPLH+A +++    +  LL+H A++ A  
Sbjct: 371 LHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430

Query: 690 KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
           + G TP H+AA  G+  I+  L+  GA  +  +    T L +A RS +  ++ +L
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485



 Score =  207 bits (528), Expect = 2e-53
 Identities = 125/384 (32%), Positives = 190/384 (49%)

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           N +TPLH    +G+   V+LLL     +D +T  G TPL   A+     +  +LL   A 
Sbjct: 267 NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
                ++G +PLH A Q       +LLL H   VD    +  T LH+AA      VA++L
Sbjct: 327 ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
           + ++A+PN     G TPLH+A     + +++LL   GA + A   +  TP+H+A   G V
Sbjct: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHV 446

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
             +  L+  GA P+  +  G   LH AA  G+  + + L++ GA +E       TPLH++
Sbjct: 447 NIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS 506

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
           A  G  +I+  L +  A+  A     +TPLHL+AR G E V + LL  GA  +   + G+
Sbjct: 507 ARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGF 566

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLH+A +         LL+  A+  A  K G TP H+AA   N  +  +L++ GA    
Sbjct: 567 TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626

Query: 721 QDGVSCTPLQLALRSRKQGIMSFL 744
                 TPL +A +  +  I + L
Sbjct: 627 AAKNGYTPLHIAAKKNQMDIATTL 650



 Score =  201 bits (511), Expect = 2e-51
 Identities = 118/348 (33%), Positives = 183/348 (52%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           T LH     G  E VR L+     V+ +     TPL I+A+  + D+   LL  GA  N 
Sbjct: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
               G+ PLH +A+ G +  A  LLDHGA +    ++G+TPLH+AA+     VA LL+ +
Sbjct: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587

Query: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
            A P+     G TPLHVAA++ +  +  LL  QGA   A  +N  TPLH+A ++ ++   
Sbjct: 588 SASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIA 647

Query: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
             LL+ GA  +A+ + G   +H AA  G   +  +LL   A++ L    G TPLHLAA +
Sbjct: 648 TTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQE 707

Query: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663
             + +  +L    A++ A   + +TPLH+   +G   +V+ LLQ  A  NA  ++G+TPL
Sbjct: 708 DRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPL 767

Query: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVL 711
           H A Q+     +  LL+++A+ +     G T   +A   G  +++  L
Sbjct: 768 HQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815



 Score =  136 bits (342), Expect = 8e-32
 Identities = 80/209 (38%), Positives = 111/209 (53%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
           +TPLH      + +   LLL           +GYTPL IAA+  Q D+   LL +GADAN
Sbjct: 599 LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN 658

Query: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482
            V   G A +H AAQ G      LLL   A V+   + G TPLHLAAQ +  NVA +LV+
Sbjct: 659 AVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVN 718

Query: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542
           + A  +     G TPLHV  ++G++ +V  L    A+++A+ +N  TPLH A ++G    
Sbjct: 719 QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI 778

Query: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARG 571
           I  LL++ A P+ L  +G   L  A   G
Sbjct: 779 INVLLQNNASPNELTVNGNTALGIARRLG 807



 Score =  102 bits (254), Expect = 1e-21
 Identities = 59/187 (31%), Positives = 88/187 (47%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N  TPLH    +  ++    LL +  D +  T  G   + +AAQ+   D+ +LLL   A
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA 688

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
           + N  ++ G  PLH AAQ      A +L++ GA VDAQ + G+TPLH+        +   
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNF 748

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+   A  N     G TPLH AA  GH  ++ +L    A  +    N  T L +A   G 
Sbjct: 749 LLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGY 808

Query: 540 VRAIQHL 546
           +  +  L
Sbjct: 809 ISVVDTL 815


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  235 bits (599), Expect = 1e-61
 Identities = 145/398 (36%), Positives = 214/398 (53%), Gaps = 2/398 (0%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           TPLH      ++   +LLL     V+    +G TPL IA++     +  LLL  GA    
Sbjct: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 300

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
             +D   PLH AA+NG    + +LLDHGA + A+ + G +P+H+AAQ +  +  RLL+  
Sbjct: 301 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 360

Query: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
            A+ +    +  TPLHVAA+ GH  + K+L  +GA+ +++  N  TPLH+A ++  VR +
Sbjct: 361 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 420

Query: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
           + LLK+GA  DA+ +SG  PLH A+  G   I K LL+ GAS  +   +  TPLH+AA  
Sbjct: 421 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 480

Query: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663
           GH E+   L ++ A + A    + TPLH AAR G   +V  LL+  A+PN A  +G TPL
Sbjct: 481 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540

Query: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723
           H+A +     +V+ LLE  A+     K G+TP H+AA  G   + ++L+E  A  +    
Sbjct: 541 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 600

Query: 724 VSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
              TPL +A+      I+  L   G  P      G  P
Sbjct: 601 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTP 638



 Score =  231 bits (590), Expect = 1e-60
 Identities = 134/389 (34%), Positives = 208/389 (53%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           ++++TPLH     G V    +LL H   +  +T +G +P+ +AAQ    D   LLL + A
Sbjct: 303 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 362

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
           + + +  D   PLH AA  G    A++LLD GA  +++   G+TPLH+A + N   V  L
Sbjct: 363 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 422

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+   A  +     G TPLHVA++ GH+ +VK L  +GA  +     + TPLH+A   G 
Sbjct: 423 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 482

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
               ++LL++ A  +A  +    PLH AA  G   + K+LL   A+  L T  G TPLH+
Sbjct: 483 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 542

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA +GH+E +  L E  A+   +    +TPLH+AA++G+  V   LL+  A PNAA ++G
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 602

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
            TPLH+AV  +    V  LL    + H+    G+TP H+AA +    + + L++ G   +
Sbjct: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 662

Query: 720 VQDGVSCTPLQLALRSRKQGIMSFLEGKE 748
            +     TPL LA +     +++ L  K+
Sbjct: 663 AESVQGVTPLHLAAQEGHAEMVALLLSKQ 691



 Score =  223 bits (569), Expect = 4e-58
 Identities = 140/401 (34%), Positives = 204/401 (50%), Gaps = 2/401 (0%)

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           N  TPLH    +  V  + LLL     +D  T SG TPL +A+      +   LL  GA 
Sbjct: 403 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 462

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
            N  +     PLH AA+ G    A+ LL + A V+A+ ++  TPLH AA+    N+ +LL
Sbjct: 463 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 522

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
           +   A+PNL    G TPLH+AA  GHV  V  L  + A      +   TPLH+A + GKV
Sbjct: 523 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 582

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
           R  + LL+  A P+A  ++G  PLH A       I K+LL  G S   P   G+TPLH+A
Sbjct: 583 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 642

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
           A +  +E+   L +   +  A      TPLHLAA+ G   +V+ LL   A+ N   +SG 
Sbjct: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 702

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLHL  Q         L++H   V A  ++G+TP H+A+  GN  ++K L++  A ++ 
Sbjct: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 762

Query: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
           +  +  +PL  A +     I++ L   G  P+  +  G+ P
Sbjct: 763 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 803



 Score =  217 bits (553), Expect = 3e-56
 Identities = 151/455 (33%), Positives = 229/455 (50%), Gaps = 66/455 (14%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           T LH     G  E VR L+ +  +V+ Q+  G+TPL +AAQ+   ++   LL +GA+ N 
Sbjct: 113 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 172

Query: 424 VDEDGWAPL-----------------------------HFAAQNGDDGTARLLLDHGACV 454
             EDG+ PL                             H AA+N D  TA +LL +    
Sbjct: 173 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 232

Query: 455 DAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLT 514
           D   + G+TPLH+AA     NVA+LL++R A  N     G TPLH+A+  G+V +V+LL 
Sbjct: 233 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 292

Query: 515 SQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL 574
            +GA+++ + ++  TPLH A   G VR  + LL  GA   A  ++G  P+H AA +G +L
Sbjct: 293 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHL 351

Query: 575 IC-KMLLRYGASLE-------LPTH--------------------------QGWTPLHLA 600
            C ++LL+Y A ++        P H                           G+TPLH+A
Sbjct: 352 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA 411

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
             K H+ ++ LL ++ A++ A+     TPLH+A+  G   +V  LLQ GA PN +     
Sbjct: 412 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 471

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLH+A +         LL++ A V+A+ K   TP H AA  G+T ++K+L+E  A  ++
Sbjct: 472 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 531

Query: 721 QDGVSCTPLQLALR-SRKQGIMSFLEGKEPSVATL 754
                 TPL +A R    + +++ LE KE S A +
Sbjct: 532 ATTAGHTPLHIAAREGHVETVLALLE-KEASQACM 565



 Score =  217 bits (553), Expect = 3e-56
 Identities = 134/378 (35%), Positives = 193/378 (51%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N +TPLH    +G+V  VRLLL     ++ +T    TPL  AA++    +  +LL HGA
Sbjct: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
                 ++G +P+H AAQ       RLLL + A +D    +  TPLH+AA      VA++
Sbjct: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 389

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+ + A PN     G TPLH+A    HV +++LL   GA +DA   +  TPLH+A   G 
Sbjct: 390 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 449

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
           +  +++LL+ GA P+  +     PLH AA  G   + K LL+  A +        TPLH 
Sbjct: 450 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 509

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  GH  ++ LL E++AN         TPLH+AAR G    V ALL+  A      + G
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH+A +         LLE  A+ +A  K G TP H+A    N  I+K+L+  G    
Sbjct: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629

Query: 720 VQDGVSCTPLQLALRSRK 737
                  TPL +A +  +
Sbjct: 630 SPAWNGYTPLHIAAKQNQ 647



 Score =  214 bits (545), Expect = 2e-55
 Identities = 133/400 (33%), Positives = 203/400 (50%), Gaps = 2/400 (0%)

Query: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421
           ++  LH            +LL ++ + D  + +G+TPL IAA  +  ++  LLL  GA  
Sbjct: 206 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 265

Query: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
           N   ++G  PLH A++ G+    RLLLD GA ++ + ++  TPLH AA+N    ++ +L+
Sbjct: 266 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 325

Query: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
              A        G +P+H+AA   H+  V+LL    AE+D    +  TPLH+A   G  R
Sbjct: 326 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 385

Query: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAA 601
             + LL  GA P++   +G+ PLH A  +    + ++LL+ GAS++  T  G TPLH+A+
Sbjct: 386 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 445

Query: 602 YKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWT 661
           + GHL I+  L +  A+         TPLH+AAR G   V   LLQ  A  NA  +   T
Sbjct: 446 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 505

Query: 662 PLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
           PLH A +      V  LLE++AN +     G TP H+AA +G+   +  L+E  A     
Sbjct: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 565

Query: 722 DGVSCTPLQLALRSRKQGIMSFLEGKE--PSVATLGGSKP 759
                TPL +A +  K  +   L  ++  P+ A   G  P
Sbjct: 566 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTP 605



 Score =  211 bits (537), Expect = 2e-54
 Identities = 125/372 (33%), Positives = 197/372 (52%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N ++P+H       ++ VRLLL ++ ++D  T    TPL +AA      +  +LL  GA
Sbjct: 336 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 395

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
             N    +G+ PLH A +        LLL  GA +DA    G TPLH+A+      + + 
Sbjct: 396 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 455

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+ R A PN+   + +TPLH+AA  GH  + K L    A+++A+ ++ +TPLH A   G 
Sbjct: 456 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 515

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
              ++ LL++ A P+    +G+ PLH AA  G       LL   AS    T +G+TPLH+
Sbjct: 516 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 575

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  G + +  LL E  A+  A G    TPLH+A  H    +V  LL  G  P++   +G
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 635

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH+A +++      +LL++  + +A +  G TP HLAA +G+  ++ +L+   A  +
Sbjct: 636 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 695

Query: 720 VQDGVSCTPLQL 731
           + +    TPL L
Sbjct: 696 LGNKSGLTPLHL 707



 Score =  209 bits (531), Expect = 1e-53
 Identities = 130/414 (31%), Positives = 216/414 (52%), Gaps = 29/414 (7%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N +  LH    +G V+ V  LL  E+ ++  T  G T L IAA   Q ++   L+ +GA
Sbjct: 76  QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 135

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTP--------------- 464
           + N   + G+ PL+ AAQ       + LL++GA  +    +G+TP               
Sbjct: 136 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 195

Query: 465 --------------LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV 510
                         LH+AA+N+    A +L+    +P++    G TPLH+AA++ ++++ 
Sbjct: 196 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 255

Query: 511 KLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAAR 570
           +LL ++GA ++   +N  TPLH+A  RG V  ++ LL  GA  +   +    PLH AA  
Sbjct: 256 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 315

Query: 571 GKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
           G   I ++LL +GA ++  T  G +P+H+AA   HL+ + LL +  A +  +   + TPL
Sbjct: 316 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 375

Query: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNK 690
           H+AA  G   V   LL  GA PN+   +G+TPLH+A +++    +  LL+  A++ A  +
Sbjct: 376 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 435

Query: 691 VGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
            G TP H+A+  G+  I+K L++ GA  +V +    TPL +A R+    +  +L
Sbjct: 436 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489



 Score =  196 bits (497), Expect = 9e-50
 Identities = 131/380 (34%), Positives = 194/380 (51%), Gaps = 4/380 (1%)

Query: 347 KNLVPRDEELCIYENKV-TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQD 405
           KNL+ R     +   KV TPLH     G  E  + LL ++  V+ +     TPL  AA+ 
Sbjct: 454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 513

Query: 406 QQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPL 465
              ++  LLL + A+ N     G  PLH AA+ G   T   LL+  A      ++G+TPL
Sbjct: 514 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 573

Query: 466 HLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR 525
           H+AA+     VA LL+ R A PN     G TPLHVA +  ++ +VKLL  +G    +   
Sbjct: 574 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 633

Query: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS 585
           N  TPLH+A ++ +V   + LL+ G   +A    G  PLH AA  G   +  +LL   A+
Sbjct: 634 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 693

Query: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
             L    G TPLHL A +GH+ +  +L +    + A   + +TPLH+A+ +G   +V  L
Sbjct: 694 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 753

Query: 646 LQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGN- 704
           LQ  AD NA  + G++PLH A Q+     V  LL++ A+ +  +  G TP  +A   G  
Sbjct: 754 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 813

Query: 705 --TAILKVLVEAGAQLDVQD 722
             T +LKV+ +  + + V D
Sbjct: 814 SVTDVLKVVTDETSFVLVSD 833



 Score =  175 bits (443), Expect = 2e-43
 Identities = 117/373 (31%), Positives = 190/373 (50%), Gaps = 6/373 (1%)

Query: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432
           G++++    L + VD++    +G   L +A+++    +   LL          + G   L
Sbjct: 56  GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTAL 115

Query: 433 HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEA 492
           H AA  G D   R L+++GA V+AQ ++G+TPL++AAQ N   V + L+   A+ N+   
Sbjct: 116 HIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE 175

Query: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTP-LHLAVERGKVRAIQHLLKSGA 551
           +G TPL VA   GH ++V  L + G      +  +R P LH+A      R    LL++  
Sbjct: 176 DGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQNDP 230

Query: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611
            PD L ++G+ PLH AA      + ++LL  GAS+      G TPLH+A+ +G++ ++ L
Sbjct: 231 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 290

Query: 612 LAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRST 671
           L +  A +        TPLH AAR+G   +   LL  GA   A  ++G +P+H+A Q   
Sbjct: 291 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 350

Query: 672 FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731
              V  LL++ A +        TP H+AA  G+  + KVL++ GA+ + +     TPL +
Sbjct: 351 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 410

Query: 732 ALRSRKQGIMSFL 744
           A +     +M  L
Sbjct: 411 ACKKNHVRVMELL 423



 Score =  120 bits (301), Expect = 5e-27
 Identities = 82/300 (27%), Positives = 137/300 (45%), Gaps = 31/300 (10%)

Query: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
           +A+  T    AA  G++         G +++   +N    LHLA + G V+ +  LL   
Sbjct: 42  KADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 101

Query: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
            + +   + G   LH AA  G+  + + L+ YGA++   + +G+TPL++AA + HLE++ 
Sbjct: 102 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 161

Query: 611 LLAESHANM-----------------------------GALGAVNWTPLHLAARHGEEAV 641
            L E+ AN                              G  G V    LH+AAR+ +   
Sbjct: 162 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 221

Query: 642 VSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAAL 701
            + LLQ   +P+   ++G+TPLH+A           LL   A+V+   + G TP H+A+ 
Sbjct: 222 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 281

Query: 702 KGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
           +GN  ++++L++ GAQ++ +     TPL  A R+    I   L   G      T  G  P
Sbjct: 282 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 341


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  235 bits (599), Expect = 1e-61
 Identities = 145/398 (36%), Positives = 214/398 (53%), Gaps = 2/398 (0%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           TPLH      ++   +LLL     V+    +G TPL IA++     +  LLL  GA    
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
             +D   PLH AA+NG    + +LLDHGA + A+ + G +P+H+AAQ +  +  RLL+  
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327

Query: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
            A+ +    +  TPLHVAA+ GH  + K+L  +GA+ +++  N  TPLH+A ++  VR +
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387

Query: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
           + LLK+GA  DA+ +SG  PLH A+  G   I K LL+ GAS  +   +  TPLH+AA  
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447

Query: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663
           GH E+   L ++ A + A    + TPLH AAR G   +V  LL+  A+PN A  +G TPL
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507

Query: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723
           H+A +     +V+ LLE  A+     K G+TP H+AA  G   + ++L+E  A  +    
Sbjct: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567

Query: 724 VSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
              TPL +A+      I+  L   G  P      G  P
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTP 605



 Score =  231 bits (590), Expect = 1e-60
 Identities = 134/389 (34%), Positives = 208/389 (53%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           ++++TPLH     G V    +LL H   +  +T +G +P+ +AAQ    D   LLL + A
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
           + + +  D   PLH AA  G    A++LLD GA  +++   G+TPLH+A + N   V  L
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 389

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+   A  +     G TPLHVA++ GH+ +VK L  +GA  +     + TPLH+A   G 
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 449

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
               ++LL++ A  +A  +    PLH AA  G   + K+LL   A+  L T  G TPLH+
Sbjct: 450 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA +GH+E +  L E  A+   +    +TPLH+AA++G+  V   LL+  A PNAA ++G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
            TPLH+AV  +    V  LL    + H+    G+TP H+AA +    + + L++ G   +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 720 VQDGVSCTPLQLALRSRKQGIMSFLEGKE 748
            +     TPL LA +     +++ L  K+
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQ 658



 Score =  223 bits (569), Expect = 4e-58
 Identities = 140/401 (34%), Positives = 204/401 (50%), Gaps = 2/401 (0%)

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           N  TPLH    +  V  + LLL     +D  T SG TPL +A+      +   LL  GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
            N  +     PLH AA+ G    A+ LL + A V+A+ ++  TPLH AA+    N+ +LL
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
           +   A+PNL    G TPLH+AA  GHV  V  L  + A      +   TPLH+A + GKV
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
           R  + LL+  A P+A  ++G  PLH A       I K+LL  G S   P   G+TPLH+A
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
           A +  +E+   L +   +  A      TPLHLAA+ G   +V+ LL   A+ N   +SG 
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLHL  Q         L++H   V A  ++G+TP H+A+  GN  ++K L++  A ++ 
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
           +  +  +PL  A +     I++ L   G  P+  +  G+ P
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770



 Score =  217 bits (553), Expect = 3e-56
 Identities = 151/455 (33%), Positives = 229/455 (50%), Gaps = 66/455 (14%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           T LH     G  E VR L+ +  +V+ Q+  G+TPL +AAQ+   ++   LL +GA+ N 
Sbjct: 80  TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139

Query: 424 VDEDGWAPL-----------------------------HFAAQNGDDGTARLLLDHGACV 454
             EDG+ PL                             H AA+N D  TA +LL +    
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199

Query: 455 DAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLT 514
           D   + G+TPLH+AA     NVA+LL++R A  N     G TPLH+A+  G+V +V+LL 
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 515 SQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL 574
            +GA+++ + ++  TPLH A   G VR  + LL  GA   A  ++G  P+H AA +G +L
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHL 318

Query: 575 IC-KMLLRYGASLE-------LPTH--------------------------QGWTPLHLA 600
            C ++LL+Y A ++        P H                           G+TPLH+A
Sbjct: 319 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA 378

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
             K H+ ++ LL ++ A++ A+     TPLH+A+  G   +V  LLQ GA PN +     
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 438

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLH+A +         LL++ A V+A+ K   TP H AA  G+T ++K+L+E  A  ++
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498

Query: 721 QDGVSCTPLQLALR-SRKQGIMSFLEGKEPSVATL 754
                 TPL +A R    + +++ LE KE S A +
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLE-KEASQACM 532



 Score =  217 bits (553), Expect = 3e-56
 Identities = 134/378 (35%), Positives = 193/378 (51%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N +TPLH    +G+V  VRLLL     ++ +T    TPL  AA++    +  +LL HGA
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
                 ++G +P+H AAQ       RLLL + A +D    +  TPLH+AA      VA++
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+ + A PN     G TPLH+A    HV +++LL   GA +DA   +  TPLH+A   G 
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
           +  +++LL+ GA P+  +     PLH AA  G   + K LL+  A +        TPLH 
Sbjct: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  GH  ++ LL E++AN         TPLH+AAR G    V ALL+  A      + G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH+A +         LLE  A+ +A  K G TP H+A    N  I+K+L+  G    
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 720 VQDGVSCTPLQLALRSRK 737
                  TPL +A +  +
Sbjct: 597 SPAWNGYTPLHIAAKQNQ 614



 Score =  214 bits (545), Expect = 2e-55
 Identities = 133/400 (33%), Positives = 203/400 (50%), Gaps = 2/400 (0%)

Query: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421
           ++  LH            +LL ++ + D  + +G+TPL IAA  +  ++  LLL  GA  
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232

Query: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
           N   ++G  PLH A++ G+    RLLLD GA ++ + ++  TPLH AA+N    ++ +L+
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292

Query: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
              A        G +P+H+AA   H+  V+LL    AE+D    +  TPLH+A   G  R
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352

Query: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAA 601
             + LL  GA P++   +G+ PLH A  +    + ++LL+ GAS++  T  G TPLH+A+
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412

Query: 602 YKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWT 661
           + GHL I+  L +  A+         TPLH+AAR G   V   LLQ  A  NA  +   T
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472

Query: 662 PLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
           PLH A +      V  LLE++AN +     G TP H+AA +G+   +  L+E  A     
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532

Query: 722 DGVSCTPLQLALRSRKQGIMSFLEGKE--PSVATLGGSKP 759
                TPL +A +  K  +   L  ++  P+ A   G  P
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTP 572



 Score =  211 bits (537), Expect = 2e-54
 Identities = 125/372 (33%), Positives = 197/372 (52%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N ++P+H       ++ VRLLL ++ ++D  T    TPL +AA      +  +LL  GA
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
             N    +G+ PLH A +        LLL  GA +DA    G TPLH+A+      + + 
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+ R A PN+   + +TPLH+AA  GH  + K L    A+++A+ ++ +TPLH A   G 
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
              ++ LL++ A P+    +G+ PLH AA  G       LL   AS    T +G+TPLH+
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  G + +  LL E  A+  A G    TPLH+A  H    +V  LL  G  P++   +G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH+A +++      +LL++  + +A +  G TP HLAA +G+  ++ +L+   A  +
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 720 VQDGVSCTPLQL 731
           + +    TPL L
Sbjct: 663 LGNKSGLTPLHL 674



 Score =  209 bits (531), Expect = 1e-53
 Identities = 130/414 (31%), Positives = 216/414 (52%), Gaps = 29/414 (7%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N +  LH    +G V+ V  LL  E+ ++  T  G T L IAA   Q ++   L+ +GA
Sbjct: 43  QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTP--------------- 464
           + N   + G+ PL+ AAQ       + LL++GA  +    +G+TP               
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162

Query: 465 --------------LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV 510
                         LH+AA+N+    A +L+    +P++    G TPLH+AA++ ++++ 
Sbjct: 163 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 222

Query: 511 KLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAAR 570
           +LL ++GA ++   +N  TPLH+A  RG V  ++ LL  GA  +   +    PLH AA  
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 571 GKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
           G   I ++LL +GA ++  T  G +P+H+AA   HL+ + LL +  A +  +   + TPL
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342

Query: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNK 690
           H+AA  G   V   LL  GA PN+   +G+TPLH+A +++    +  LL+  A++ A  +
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402

Query: 691 VGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
            G TP H+A+  G+  I+K L++ GA  +V +    TPL +A R+    +  +L
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456



 Score =  196 bits (497), Expect = 9e-50
 Identities = 131/380 (34%), Positives = 194/380 (51%), Gaps = 4/380 (1%)

Query: 347 KNLVPRDEELCIYENKV-TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQD 405
           KNL+ R     +   KV TPLH     G  E  + LL ++  V+ +     TPL  AA+ 
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 406 QQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPL 465
              ++  LLL + A+ N     G  PLH AA+ G   T   LL+  A      ++G+TPL
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 466 HLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR 525
           H+AA+     VA LL+ R A PN     G TPLHVA +  ++ +VKLL  +G    +   
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS 585
           N  TPLH+A ++ +V   + LL+ G   +A    G  PLH AA  G   +  +LL   A+
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660

Query: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
             L    G TPLHL A +GH+ +  +L +    + A   + +TPLH+A+ +G   +V  L
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720

Query: 646 LQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGN- 704
           LQ  AD NA  + G++PLH A Q+     V  LL++ A+ +  +  G TP  +A   G  
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780

Query: 705 --TAILKVLVEAGAQLDVQD 722
             T +LKV+ +  + + V D
Sbjct: 781 SVTDVLKVVTDETSFVLVSD 800



 Score =  175 bits (443), Expect = 2e-43
 Identities = 117/373 (31%), Positives = 190/373 (50%), Gaps = 6/373 (1%)

Query: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432
           G++++    L + VD++    +G   L +A+++    +   LL          + G   L
Sbjct: 23  GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTAL 82

Query: 433 HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEA 492
           H AA  G D   R L+++GA V+AQ ++G+TPL++AAQ N   V + L+   A+ N+   
Sbjct: 83  HIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE 142

Query: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTP-LHLAVERGKVRAIQHLLKSGA 551
           +G TPL VA   GH ++V  L + G      +  +R P LH+A      R    LL++  
Sbjct: 143 DGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQNDP 197

Query: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611
            PD L ++G+ PLH AA      + ++LL  GAS+      G TPLH+A+ +G++ ++ L
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257

Query: 612 LAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRST 671
           L +  A +        TPLH AAR+G   +   LL  GA   A  ++G +P+H+A Q   
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 317

Query: 672 FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731
              V  LL++ A +        TP H+AA  G+  + KVL++ GA+ + +     TPL +
Sbjct: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377

Query: 732 ALRSRKQGIMSFL 744
           A +     +M  L
Sbjct: 378 ACKKNHVRVMELL 390



 Score =  122 bits (305), Expect = 2e-27
 Identities = 83/300 (27%), Positives = 137/300 (45%), Gaps = 31/300 (10%)

Query: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
           EA+  T    AA  G++         G +++   +N    LHLA + G V+ +  LL   
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
            + +   + G   LH AA  G+  + + L+ YGA++   + +G+TPL++AA + HLE++ 
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128

Query: 611 LLAESHANM-----------------------------GALGAVNWTPLHLAARHGEEAV 641
            L E+ AN                              G  G V    LH+AAR+ +   
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 188

Query: 642 VSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAAL 701
            + LLQ   +P+   ++G+TPLH+A           LL   A+V+   + G TP H+A+ 
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248

Query: 702 KGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
           +GN  ++++L++ GAQ++ +     TPL  A R+    I   L   G      T  G  P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  235 bits (599), Expect = 1e-61
 Identities = 145/398 (36%), Positives = 214/398 (53%), Gaps = 2/398 (0%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           TPLH      ++   +LLL     V+    +G TPL IA++     +  LLL  GA    
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
             +D   PLH AA+NG    + +LLDHGA + A+ + G +P+H+AAQ +  +  RLL+  
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327

Query: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
            A+ +    +  TPLHVAA+ GH  + K+L  +GA+ +++  N  TPLH+A ++  VR +
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387

Query: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
           + LLK+GA  DA+ +SG  PLH A+  G   I K LL+ GAS  +   +  TPLH+AA  
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447

Query: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663
           GH E+   L ++ A + A    + TPLH AAR G   +V  LL+  A+PN A  +G TPL
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507

Query: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723
           H+A +     +V+ LLE  A+     K G+TP H+AA  G   + ++L+E  A  +    
Sbjct: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567

Query: 724 VSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
              TPL +A+      I+  L   G  P      G  P
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTP 605



 Score =  231 bits (590), Expect = 1e-60
 Identities = 134/389 (34%), Positives = 208/389 (53%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           ++++TPLH     G V    +LL H   +  +T +G +P+ +AAQ    D   LLL + A
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
           + + +  D   PLH AA  G    A++LLD GA  +++   G+TPLH+A + N   V  L
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 389

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+   A  +     G TPLHVA++ GH+ +VK L  +GA  +     + TPLH+A   G 
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 449

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
               ++LL++ A  +A  +    PLH AA  G   + K+LL   A+  L T  G TPLH+
Sbjct: 450 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA +GH+E +  L E  A+   +    +TPLH+AA++G+  V   LL+  A PNAA ++G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
            TPLH+AV  +    V  LL    + H+    G+TP H+AA +    + + L++ G   +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 720 VQDGVSCTPLQLALRSRKQGIMSFLEGKE 748
            +     TPL LA +     +++ L  K+
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQ 658



 Score =  223 bits (569), Expect = 4e-58
 Identities = 140/401 (34%), Positives = 204/401 (50%), Gaps = 2/401 (0%)

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           N  TPLH    +  V  + LLL     +D  T SG TPL +A+      +   LL  GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
            N  +     PLH AA+ G    A+ LL + A V+A+ ++  TPLH AA+    N+ +LL
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
           +   A+PNL    G TPLH+AA  GHV  V  L  + A      +   TPLH+A + GKV
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
           R  + LL+  A P+A  ++G  PLH A       I K+LL  G S   P   G+TPLH+A
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
           A +  +E+   L +   +  A      TPLHLAA+ G   +V+ LL   A+ N   +SG 
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLHL  Q         L++H   V A  ++G+TP H+A+  GN  ++K L++  A ++ 
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
           +  +  +PL  A +     I++ L   G  P+  +  G+ P
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770



 Score =  217 bits (553), Expect = 3e-56
 Identities = 151/455 (33%), Positives = 229/455 (50%), Gaps = 66/455 (14%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           T LH     G  E VR L+ +  +V+ Q+  G+TPL +AAQ+   ++   LL +GA+ N 
Sbjct: 80  TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139

Query: 424 VDEDGWAPL-----------------------------HFAAQNGDDGTARLLLDHGACV 454
             EDG+ PL                             H AA+N D  TA +LL +    
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199

Query: 455 DAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLT 514
           D   + G+TPLH+AA     NVA+LL++R A  N     G TPLH+A+  G+V +V+LL 
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 515 SQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL 574
            +GA+++ + ++  TPLH A   G VR  + LL  GA   A  ++G  P+H AA +G +L
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHL 318

Query: 575 IC-KMLLRYGASLE-------LPTH--------------------------QGWTPLHLA 600
            C ++LL+Y A ++        P H                           G+TPLH+A
Sbjct: 319 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA 378

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
             K H+ ++ LL ++ A++ A+     TPLH+A+  G   +V  LLQ GA PN +     
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 438

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLH+A +         LL++ A V+A+ K   TP H AA  G+T ++K+L+E  A  ++
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498

Query: 721 QDGVSCTPLQLALR-SRKQGIMSFLEGKEPSVATL 754
                 TPL +A R    + +++ LE KE S A +
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLE-KEASQACM 532



 Score =  217 bits (553), Expect = 3e-56
 Identities = 134/378 (35%), Positives = 193/378 (51%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N +TPLH    +G+V  VRLLL     ++ +T    TPL  AA++    +  +LL HGA
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
                 ++G +P+H AAQ       RLLL + A +D    +  TPLH+AA      VA++
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+ + A PN     G TPLH+A    HV +++LL   GA +DA   +  TPLH+A   G 
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
           +  +++LL+ GA P+  +     PLH AA  G   + K LL+  A +        TPLH 
Sbjct: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  GH  ++ LL E++AN         TPLH+AAR G    V ALL+  A      + G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH+A +         LLE  A+ +A  K G TP H+A    N  I+K+L+  G    
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 720 VQDGVSCTPLQLALRSRK 737
                  TPL +A +  +
Sbjct: 597 SPAWNGYTPLHIAAKQNQ 614



 Score =  214 bits (545), Expect = 2e-55
 Identities = 133/400 (33%), Positives = 203/400 (50%), Gaps = 2/400 (0%)

Query: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421
           ++  LH            +LL ++ + D  + +G+TPL IAA  +  ++  LLL  GA  
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232

Query: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
           N   ++G  PLH A++ G+    RLLLD GA ++ + ++  TPLH AA+N    ++ +L+
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292

Query: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
              A        G +P+H+AA   H+  V+LL    AE+D    +  TPLH+A   G  R
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352

Query: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAA 601
             + LL  GA P++   +G+ PLH A  +    + ++LL+ GAS++  T  G TPLH+A+
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412

Query: 602 YKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWT 661
           + GHL I+  L +  A+         TPLH+AAR G   V   LLQ  A  NA  +   T
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472

Query: 662 PLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
           PLH A +      V  LLE++AN +     G TP H+AA +G+   +  L+E  A     
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532

Query: 722 DGVSCTPLQLALRSRKQGIMSFLEGKE--PSVATLGGSKP 759
                TPL +A +  K  +   L  ++  P+ A   G  P
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTP 572



 Score =  211 bits (537), Expect = 2e-54
 Identities = 125/372 (33%), Positives = 197/372 (52%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N ++P+H       ++ VRLLL ++ ++D  T    TPL +AA      +  +LL  GA
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
             N    +G+ PLH A +        LLL  GA +DA    G TPLH+A+      + + 
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+ R A PN+   + +TPLH+AA  GH  + K L    A+++A+ ++ +TPLH A   G 
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
              ++ LL++ A P+    +G+ PLH AA  G       LL   AS    T +G+TPLH+
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  G + +  LL E  A+  A G    TPLH+A  H    +V  LL  G  P++   +G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH+A +++      +LL++  + +A +  G TP HLAA +G+  ++ +L+   A  +
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 720 VQDGVSCTPLQL 731
           + +    TPL L
Sbjct: 663 LGNKSGLTPLHL 674



 Score =  209 bits (531), Expect = 1e-53
 Identities = 130/414 (31%), Positives = 216/414 (52%), Gaps = 29/414 (7%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N +  LH    +G V+ V  LL  E+ ++  T  G T L IAA   Q ++   L+ +GA
Sbjct: 43  QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTP--------------- 464
           + N   + G+ PL+ AAQ       + LL++GA  +    +G+TP               
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162

Query: 465 --------------LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV 510
                         LH+AA+N+    A +L+    +P++    G TPLH+AA++ ++++ 
Sbjct: 163 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 222

Query: 511 KLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAAR 570
           +LL ++GA ++   +N  TPLH+A  RG V  ++ LL  GA  +   +    PLH AA  
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 571 GKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
           G   I ++LL +GA ++  T  G +P+H+AA   HL+ + LL +  A +  +   + TPL
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342

Query: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNK 690
           H+AA  G   V   LL  GA PN+   +G+TPLH+A +++    +  LL+  A++ A  +
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402

Query: 691 VGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
            G TP H+A+  G+  I+K L++ GA  +V +    TPL +A R+    +  +L
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456



 Score =  196 bits (497), Expect = 9e-50
 Identities = 131/380 (34%), Positives = 194/380 (51%), Gaps = 4/380 (1%)

Query: 347 KNLVPRDEELCIYENKV-TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQD 405
           KNL+ R     +   KV TPLH     G  E  + LL ++  V+ +     TPL  AA+ 
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 406 QQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPL 465
              ++  LLL + A+ N     G  PLH AA+ G   T   LL+  A      ++G+TPL
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 466 HLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR 525
           H+AA+     VA LL+ R A PN     G TPLHVA +  ++ +VKLL  +G    +   
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS 585
           N  TPLH+A ++ +V   + LL+ G   +A    G  PLH AA  G   +  +LL   A+
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660

Query: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
             L    G TPLHL A +GH+ +  +L +    + A   + +TPLH+A+ +G   +V  L
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720

Query: 646 LQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGN- 704
           LQ  AD NA  + G++PLH A Q+     V  LL++ A+ +  +  G TP  +A   G  
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780

Query: 705 --TAILKVLVEAGAQLDVQD 722
             T +LKV+ +  + + V D
Sbjct: 781 SVTDVLKVVTDETSFVLVSD 800



 Score =  175 bits (443), Expect = 2e-43
 Identities = 117/373 (31%), Positives = 190/373 (50%), Gaps = 6/373 (1%)

Query: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432
           G++++    L + VD++    +G   L +A+++    +   LL          + G   L
Sbjct: 23  GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTAL 82

Query: 433 HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEA 492
           H AA  G D   R L+++GA V+AQ ++G+TPL++AAQ N   V + L+   A+ N+   
Sbjct: 83  HIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE 142

Query: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTP-LHLAVERGKVRAIQHLLKSGA 551
           +G TPL VA   GH ++V  L + G      +  +R P LH+A      R    LL++  
Sbjct: 143 DGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQNDP 197

Query: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611
            PD L ++G+ PLH AA      + ++LL  GAS+      G TPLH+A+ +G++ ++ L
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257

Query: 612 LAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRST 671
           L +  A +        TPLH AAR+G   +   LL  GA   A  ++G +P+H+A Q   
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 317

Query: 672 FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731
              V  LL++ A +        TP H+AA  G+  + KVL++ GA+ + +     TPL +
Sbjct: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377

Query: 732 ALRSRKQGIMSFL 744
           A +     +M  L
Sbjct: 378 ACKKNHVRVMELL 390



 Score =  122 bits (305), Expect = 2e-27
 Identities = 83/300 (27%), Positives = 137/300 (45%), Gaps = 31/300 (10%)

Query: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
           EA+  T    AA  G++         G +++   +N    LHLA + G V+ +  LL   
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
            + +   + G   LH AA  G+  + + L+ YGA++   + +G+TPL++AA + HLE++ 
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128

Query: 611 LLAESHANM-----------------------------GALGAVNWTPLHLAARHGEEAV 641
            L E+ AN                              G  G V    LH+AAR+ +   
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 188

Query: 642 VSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAAL 701
            + LLQ   +P+   ++G+TPLH+A           LL   A+V+   + G TP H+A+ 
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248

Query: 702 KGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
           +GN  ++++L++ GAQ++ +     TPL  A R+    I   L   G      T  G  P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  235 bits (599), Expect = 1e-61
 Identities = 145/398 (36%), Positives = 214/398 (53%), Gaps = 2/398 (0%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           TPLH      ++   +LLL     V+    +G TPL IA++     +  LLL  GA    
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
             +D   PLH AA+NG    + +LLDHGA + A+ + G +P+H+AAQ +  +  RLL+  
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327

Query: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
            A+ +    +  TPLHVAA+ GH  + K+L  +GA+ +++  N  TPLH+A ++  VR +
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387

Query: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
           + LLK+GA  DA+ +SG  PLH A+  G   I K LL+ GAS  +   +  TPLH+AA  
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447

Query: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663
           GH E+   L ++ A + A    + TPLH AAR G   +V  LL+  A+PN A  +G TPL
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507

Query: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723
           H+A +     +V+ LLE  A+     K G+TP H+AA  G   + ++L+E  A  +    
Sbjct: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567

Query: 724 VSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
              TPL +A+      I+  L   G  P      G  P
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTP 605



 Score =  231 bits (590), Expect = 1e-60
 Identities = 134/389 (34%), Positives = 208/389 (53%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           ++++TPLH     G V    +LL H   +  +T +G +P+ +AAQ    D   LLL + A
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
           + + +  D   PLH AA  G    A++LLD GA  +++   G+TPLH+A + N   V  L
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 389

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+   A  +     G TPLHVA++ GH+ +VK L  +GA  +     + TPLH+A   G 
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 449

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
               ++LL++ A  +A  +    PLH AA  G   + K+LL   A+  L T  G TPLH+
Sbjct: 450 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA +GH+E +  L E  A+   +    +TPLH+AA++G+  V   LL+  A PNAA ++G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
            TPLH+AV  +    V  LL    + H+    G+TP H+AA +    + + L++ G   +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 720 VQDGVSCTPLQLALRSRKQGIMSFLEGKE 748
            +     TPL LA +     +++ L  K+
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQ 658



 Score =  223 bits (569), Expect = 4e-58
 Identities = 140/401 (34%), Positives = 204/401 (50%), Gaps = 2/401 (0%)

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           N  TPLH    +  V  + LLL     +D  T SG TPL +A+      +   LL  GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
            N  +     PLH AA+ G    A+ LL + A V+A+ ++  TPLH AA+    N+ +LL
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
           +   A+PNL    G TPLH+AA  GHV  V  L  + A      +   TPLH+A + GKV
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
           R  + LL+  A P+A  ++G  PLH A       I K+LL  G S   P   G+TPLH+A
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
           A +  +E+   L +   +  A      TPLHLAA+ G   +V+ LL   A+ N   +SG 
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLHL  Q         L++H   V A  ++G+TP H+A+  GN  ++K L++  A ++ 
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
           +  +  +PL  A +     I++ L   G  P+  +  G+ P
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770



 Score =  217 bits (553), Expect = 3e-56
 Identities = 151/455 (33%), Positives = 229/455 (50%), Gaps = 66/455 (14%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           T LH     G  E VR L+ +  +V+ Q+  G+TPL +AAQ+   ++   LL +GA+ N 
Sbjct: 80  TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139

Query: 424 VDEDGWAPL-----------------------------HFAAQNGDDGTARLLLDHGACV 454
             EDG+ PL                             H AA+N D  TA +LL +    
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199

Query: 455 DAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLT 514
           D   + G+TPLH+AA     NVA+LL++R A  N     G TPLH+A+  G+V +V+LL 
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 515 SQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL 574
            +GA+++ + ++  TPLH A   G VR  + LL  GA   A  ++G  P+H AA +G +L
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHL 318

Query: 575 IC-KMLLRYGASLE-------LPTH--------------------------QGWTPLHLA 600
            C ++LL+Y A ++        P H                           G+TPLH+A
Sbjct: 319 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA 378

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
             K H+ ++ LL ++ A++ A+     TPLH+A+  G   +V  LLQ GA PN +     
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 438

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLH+A +         LL++ A V+A+ K   TP H AA  G+T ++K+L+E  A  ++
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498

Query: 721 QDGVSCTPLQLALR-SRKQGIMSFLEGKEPSVATL 754
                 TPL +A R    + +++ LE KE S A +
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLE-KEASQACM 532



 Score =  217 bits (553), Expect = 3e-56
 Identities = 134/378 (35%), Positives = 193/378 (51%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N +TPLH    +G+V  VRLLL     ++ +T    TPL  AA++    +  +LL HGA
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
                 ++G +P+H AAQ       RLLL + A +D    +  TPLH+AA      VA++
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+ + A PN     G TPLH+A    HV +++LL   GA +DA   +  TPLH+A   G 
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
           +  +++LL+ GA P+  +     PLH AA  G   + K LL+  A +        TPLH 
Sbjct: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  GH  ++ LL E++AN         TPLH+AAR G    V ALL+  A      + G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH+A +         LLE  A+ +A  K G TP H+A    N  I+K+L+  G    
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 720 VQDGVSCTPLQLALRSRK 737
                  TPL +A +  +
Sbjct: 597 SPAWNGYTPLHIAAKQNQ 614



 Score =  214 bits (545), Expect = 2e-55
 Identities = 133/400 (33%), Positives = 203/400 (50%), Gaps = 2/400 (0%)

Query: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421
           ++  LH            +LL ++ + D  + +G+TPL IAA  +  ++  LLL  GA  
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232

Query: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
           N   ++G  PLH A++ G+    RLLLD GA ++ + ++  TPLH AA+N    ++ +L+
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292

Query: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
              A        G +P+H+AA   H+  V+LL    AE+D    +  TPLH+A   G  R
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352

Query: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAA 601
             + LL  GA P++   +G+ PLH A  +    + ++LL+ GAS++  T  G TPLH+A+
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412

Query: 602 YKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWT 661
           + GHL I+  L +  A+         TPLH+AAR G   V   LLQ  A  NA  +   T
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472

Query: 662 PLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
           PLH A +      V  LLE++AN +     G TP H+AA +G+   +  L+E  A     
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532

Query: 722 DGVSCTPLQLALRSRKQGIMSFLEGKE--PSVATLGGSKP 759
                TPL +A +  K  +   L  ++  P+ A   G  P
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTP 572



 Score =  211 bits (537), Expect = 2e-54
 Identities = 125/372 (33%), Positives = 197/372 (52%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N ++P+H       ++ VRLLL ++ ++D  T    TPL +AA      +  +LL  GA
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
             N    +G+ PLH A +        LLL  GA +DA    G TPLH+A+      + + 
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+ R A PN+   + +TPLH+AA  GH  + K L    A+++A+ ++ +TPLH A   G 
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
              ++ LL++ A P+    +G+ PLH AA  G       LL   AS    T +G+TPLH+
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  G + +  LL E  A+  A G    TPLH+A  H    +V  LL  G  P++   +G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH+A +++      +LL++  + +A +  G TP HLAA +G+  ++ +L+   A  +
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 720 VQDGVSCTPLQL 731
           + +    TPL L
Sbjct: 663 LGNKSGLTPLHL 674



 Score =  209 bits (531), Expect = 1e-53
 Identities = 130/414 (31%), Positives = 216/414 (52%), Gaps = 29/414 (7%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N +  LH    +G V+ V  LL  E+ ++  T  G T L IAA   Q ++   L+ +GA
Sbjct: 43  QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTP--------------- 464
           + N   + G+ PL+ AAQ       + LL++GA  +    +G+TP               
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162

Query: 465 --------------LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV 510
                         LH+AA+N+    A +L+    +P++    G TPLH+AA++ ++++ 
Sbjct: 163 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 222

Query: 511 KLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAAR 570
           +LL ++GA ++   +N  TPLH+A  RG V  ++ LL  GA  +   +    PLH AA  
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 571 GKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
           G   I ++LL +GA ++  T  G +P+H+AA   HL+ + LL +  A +  +   + TPL
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342

Query: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNK 690
           H+AA  G   V   LL  GA PN+   +G+TPLH+A +++    +  LL+  A++ A  +
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402

Query: 691 VGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
            G TP H+A+  G+  I+K L++ GA  +V +    TPL +A R+    +  +L
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456



 Score =  196 bits (497), Expect = 9e-50
 Identities = 131/380 (34%), Positives = 194/380 (51%), Gaps = 4/380 (1%)

Query: 347 KNLVPRDEELCIYENKV-TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQD 405
           KNL+ R     +   KV TPLH     G  E  + LL ++  V+ +     TPL  AA+ 
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 406 QQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPL 465
              ++  LLL + A+ N     G  PLH AA+ G   T   LL+  A      ++G+TPL
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 466 HLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR 525
           H+AA+     VA LL+ R A PN     G TPLHVA +  ++ +VKLL  +G    +   
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS 585
           N  TPLH+A ++ +V   + LL+ G   +A    G  PLH AA  G   +  +LL   A+
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660

Query: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
             L    G TPLHL A +GH+ +  +L +    + A   + +TPLH+A+ +G   +V  L
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720

Query: 646 LQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGN- 704
           LQ  AD NA  + G++PLH A Q+     V  LL++ A+ +  +  G TP  +A   G  
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780

Query: 705 --TAILKVLVEAGAQLDVQD 722
             T +LKV+ +  + + V D
Sbjct: 781 SVTDVLKVVTDETSFVLVSD 800



 Score =  175 bits (443), Expect = 2e-43
 Identities = 117/373 (31%), Positives = 190/373 (50%), Gaps = 6/373 (1%)

Query: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432
           G++++    L + VD++    +G   L +A+++    +   LL          + G   L
Sbjct: 23  GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTAL 82

Query: 433 HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEA 492
           H AA  G D   R L+++GA V+AQ ++G+TPL++AAQ N   V + L+   A+ N+   
Sbjct: 83  HIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE 142

Query: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTP-LHLAVERGKVRAIQHLLKSGA 551
           +G TPL VA   GH ++V  L + G      +  +R P LH+A      R    LL++  
Sbjct: 143 DGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQNDP 197

Query: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611
            PD L ++G+ PLH AA      + ++LL  GAS+      G TPLH+A+ +G++ ++ L
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257

Query: 612 LAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRST 671
           L +  A +        TPLH AAR+G   +   LL  GA   A  ++G +P+H+A Q   
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 317

Query: 672 FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731
              V  LL++ A +        TP H+AA  G+  + KVL++ GA+ + +     TPL +
Sbjct: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377

Query: 732 ALRSRKQGIMSFL 744
           A +     +M  L
Sbjct: 378 ACKKNHVRVMELL 390



 Score =  122 bits (305), Expect = 2e-27
 Identities = 83/300 (27%), Positives = 137/300 (45%), Gaps = 31/300 (10%)

Query: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
           EA+  T    AA  G++         G +++   +N    LHLA + G V+ +  LL   
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
            + +   + G   LH AA  G+  + + L+ YGA++   + +G+TPL++AA + HLE++ 
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128

Query: 611 LLAESHANM-----------------------------GALGAVNWTPLHLAARHGEEAV 641
            L E+ AN                              G  G V    LH+AAR+ +   
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 188

Query: 642 VSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAAL 701
            + LLQ   +P+   ++G+TPLH+A           LL   A+V+   + G TP H+A+ 
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248

Query: 702 KGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
           +GN  ++++L++ GAQ++ +     TPL  A R+    I   L   G      T  G  P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  235 bits (599), Expect = 1e-61
 Identities = 145/398 (36%), Positives = 214/398 (53%), Gaps = 2/398 (0%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           TPLH      ++   +LLL     V+    +G TPL IA++     +  LLL  GA    
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
             +D   PLH AA+NG    + +LLDHGA + A+ + G +P+H+AAQ +  +  RLL+  
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327

Query: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
            A+ +    +  TPLHVAA+ GH  + K+L  +GA+ +++  N  TPLH+A ++  VR +
Sbjct: 328 DAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387

Query: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
           + LLK+GA  DA+ +SG  PLH A+  G   I K LL+ GAS  +   +  TPLH+AA  
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447

Query: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663
           GH E+   L ++ A + A    + TPLH AAR G   +V  LL+  A+PN A  +G TPL
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507

Query: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723
           H+A +     +V+ LLE  A+     K G+TP H+AA  G   + ++L+E  A  +    
Sbjct: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567

Query: 724 VSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
              TPL +A+      I+  L   G  P      G  P
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTP 605



 Score =  231 bits (590), Expect = 1e-60
 Identities = 134/389 (34%), Positives = 208/389 (53%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           ++++TPLH     G V    +LL H   +  +T +G +P+ +AAQ    D   LLL + A
Sbjct: 270 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
           + + +  D   PLH AA  G    A++LLD GA  +++   G+TPLH+A + N   V  L
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 389

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+   A  +     G TPLHVA++ GH+ +VK L  +GA  +     + TPLH+A   G 
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 449

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
               ++LL++ A  +A  +    PLH AA  G   + K+LL   A+  L T  G TPLH+
Sbjct: 450 TEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA +GH+E +  L E  A+   +    +TPLH+AA++G+  V   LL+  A PNAA ++G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
            TPLH+AV  +    V  LL    + H+    G+TP H+AA +    + + L++ G   +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 720 VQDGVSCTPLQLALRSRKQGIMSFLEGKE 748
            +     TPL LA +     +++ L  K+
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQ 658



 Score =  223 bits (569), Expect = 4e-58
 Identities = 140/401 (34%), Positives = 204/401 (50%), Gaps = 2/401 (0%)

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           N  TPLH    +  V  + LLL     +D  T SG TPL +A+      +   LL  GA 
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
            N  +     PLH AA+ G    A+ LL + A V+A+ ++  TPLH AA+    N+ +LL
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
           +   A+PNL    G TPLH+AA  GHV  V  L  + A      +   TPLH+A + GKV
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
           R  + LL+  A P+A  ++G  PLH A       I K+LL  G S   P   G+TPLH+A
Sbjct: 550 RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
           A +  +E+   L +   +  A      TPLHLAA+ G   +V+ LL   A+ N   +SG 
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLHL  Q         L++H   V A  ++G+TP H+A+  GN  ++K L++  A ++ 
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729

Query: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
           +  +  +PL  A +     I++ L   G  P+  +  G+ P
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770



 Score =  217 bits (553), Expect = 3e-56
 Identities = 151/455 (33%), Positives = 229/455 (50%), Gaps = 66/455 (14%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           T LH     G  E VR L+ +  +V+ Q+  G+TPL +AAQ+   ++   LL +GA+ N 
Sbjct: 80  TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139

Query: 424 VDEDGWAPL-----------------------------HFAAQNGDDGTARLLLDHGACV 454
             EDG+ PL                             H AA+N D  TA +LL +    
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199

Query: 455 DAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLT 514
           D   + G+TPLH+AA     NVA+LL++R A  N     G TPLH+A+  G+V +V+LL 
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 515 SQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL 574
            +GA+++ + ++  TPLH A   G VR  + LL  GA   A  ++G  P+H AA +G +L
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHL 318

Query: 575 IC-KMLLRYGASLE-------LPTH--------------------------QGWTPLHLA 600
            C ++LL+Y A ++        P H                           G+TPLH+A
Sbjct: 319 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA 378

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
             K H+ ++ LL ++ A++ A+     TPLH+A+  G   +V  LLQ GA PN +     
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 438

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLH+A +         LL++ A V+A+ K   TP H AA  G+T ++K+L+E  A  ++
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498

Query: 721 QDGVSCTPLQLALR-SRKQGIMSFLEGKEPSVATL 754
                 TPL +A R    + +++ LE KE S A +
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLE-KEASQACM 532



 Score =  217 bits (553), Expect = 3e-56
 Identities = 134/378 (35%), Positives = 193/378 (51%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N +TPLH    +G+V  VRLLL     ++ +T    TPL  AA++    +  +LL HGA
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
                 ++G +P+H AAQ       RLLL + A +D    +  TPLH+AA      VA++
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+ + A PN     G TPLH+A    HV +++LL   GA +DA   +  TPLH+A   G 
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
           +  +++LL+ GA P+  +     PLH AA  G   + K LL+  A +        TPLH 
Sbjct: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  GH  ++ LL E++AN         TPLH+AAR G    V ALL+  A      + G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH+A +         LLE  A+ +A  K G TP H+A    N  I+K+L+  G    
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 720 VQDGVSCTPLQLALRSRK 737
                  TPL +A +  +
Sbjct: 597 SPAWNGYTPLHIAAKQNQ 614



 Score =  214 bits (545), Expect = 2e-55
 Identities = 133/400 (33%), Positives = 203/400 (50%), Gaps = 2/400 (0%)

Query: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421
           ++  LH            +LL ++ + D  + +G+TPL IAA  +  ++  LLL  GA  
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232

Query: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
           N   ++G  PLH A++ G+    RLLLD GA ++ + ++  TPLH AA+N    ++ +L+
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292

Query: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
              A        G +P+H+AA   H+  V+LL    AE+D    +  TPLH+A   G  R
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352

Query: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAA 601
             + LL  GA P++   +G+ PLH A  +    + ++LL+ GAS++  T  G TPLH+A+
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412

Query: 602 YKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWT 661
           + GHL I+  L +  A+         TPLH+AAR G   V   LLQ  A  NA  +   T
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472

Query: 662 PLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
           PLH A +      V  LLE++AN +     G TP H+AA +G+   +  L+E  A     
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532

Query: 722 DGVSCTPLQLALRSRKQGIMSFLEGKE--PSVATLGGSKP 759
                TPL +A +  K  +   L  ++  P+ A   G  P
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTP 572



 Score =  211 bits (537), Expect = 2e-54
 Identities = 125/372 (33%), Positives = 197/372 (52%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N ++P+H       ++ VRLLL ++ ++D  T    TPL +AA      +  +LL  GA
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
             N    +G+ PLH A +        LLL  GA +DA    G TPLH+A+      + + 
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+ R A PN+   + +TPLH+AA  GH  + K L    A+++A+ ++ +TPLH A   G 
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
              ++ LL++ A P+    +G+ PLH AA  G       LL   AS    T +G+TPLH+
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  G + +  LL E  A+  A G    TPLH+A  H    +V  LL  G  P++   +G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH+A +++      +LL++  + +A +  G TP HLAA +G+  ++ +L+   A  +
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 720 VQDGVSCTPLQL 731
           + +    TPL L
Sbjct: 663 LGNKSGLTPLHL 674



 Score =  209 bits (531), Expect = 1e-53
 Identities = 130/414 (31%), Positives = 216/414 (52%), Gaps = 29/414 (7%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N +  LH    +G V+ V  LL  E+ ++  T  G T L IAA   Q ++   L+ +GA
Sbjct: 43  QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTP--------------- 464
           + N   + G+ PL+ AAQ       + LL++GA  +    +G+TP               
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162

Query: 465 --------------LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV 510
                         LH+AA+N+    A +L+    +P++    G TPLH+AA++ ++++ 
Sbjct: 163 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 222

Query: 511 KLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAAR 570
           +LL ++GA ++   +N  TPLH+A  RG V  ++ LL  GA  +   +    PLH AA  
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282

Query: 571 GKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
           G   I ++LL +GA ++  T  G +P+H+AA   HL+ + LL +  A +  +   + TPL
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342

Query: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNK 690
           H+AA  G   V   LL  GA PN+   +G+TPLH+A +++    +  LL+  A++ A  +
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 402

Query: 691 VGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
            G TP H+A+  G+  I+K L++ GA  +V +    TPL +A R+    +  +L
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456



 Score =  196 bits (497), Expect = 9e-50
 Identities = 131/380 (34%), Positives = 194/380 (51%), Gaps = 4/380 (1%)

Query: 347 KNLVPRDEELCIYENKV-TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQD 405
           KNL+ R     +   KV TPLH     G  E  + LL ++  V+ +     TPL  AA+ 
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 406 QQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPL 465
              ++  LLL + A+ N     G  PLH AA+ G   T   LL+  A      ++G+TPL
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 466 HLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR 525
           H+AA+     VA LL+ R A PN     G TPLHVA +  ++ +VKLL  +G    +   
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS 585
           N  TPLH+A ++ +V   + LL+ G   +A    G  PLH AA  G   +  +LL   A+
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660

Query: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
             L    G TPLHL A +GH+ +  +L +    + A   + +TPLH+A+ +G   +V  L
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720

Query: 646 LQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGN- 704
           LQ  AD NA  + G++PLH A Q+     V  LL++ A+ +  +  G TP  +A   G  
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780

Query: 705 --TAILKVLVEAGAQLDVQD 722
             T +LKV+ +  + + V D
Sbjct: 781 SVTDVLKVVTDETSFVLVSD 800



 Score =  175 bits (443), Expect = 2e-43
 Identities = 117/373 (31%), Positives = 190/373 (50%), Gaps = 6/373 (1%)

Query: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432
           G++++    L + VD++    +G   L +A+++    +   LL          + G   L
Sbjct: 23  GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTAL 82

Query: 433 HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEA 492
           H AA  G D   R L+++GA V+AQ ++G+TPL++AAQ N   V + L+   A+ N+   
Sbjct: 83  HIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE 142

Query: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTP-LHLAVERGKVRAIQHLLKSGA 551
           +G TPL VA   GH ++V  L + G      +  +R P LH+A      R    LL++  
Sbjct: 143 DGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQNDP 197

Query: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611
            PD L ++G+ PLH AA      + ++LL  GAS+      G TPLH+A+ +G++ ++ L
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257

Query: 612 LAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRST 671
           L +  A +        TPLH AAR+G   +   LL  GA   A  ++G +P+H+A Q   
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 317

Query: 672 FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731
              V  LL++ A +        TP H+AA  G+  + KVL++ GA+ + +     TPL +
Sbjct: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377

Query: 732 ALRSRKQGIMSFL 744
           A +     +M  L
Sbjct: 378 ACKKNHVRVMELL 390



 Score =  122 bits (305), Expect = 2e-27
 Identities = 83/300 (27%), Positives = 137/300 (45%), Gaps = 31/300 (10%)

Query: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
           EA+  T    AA  G++         G +++   +N    LHLA + G V+ +  LL   
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
            + +   + G   LH AA  G+  + + L+ YGA++   + +G+TPL++AA + HLE++ 
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128

Query: 611 LLAESHANM-----------------------------GALGAVNWTPLHLAARHGEEAV 641
            L E+ AN                              G  G V    LH+AAR+ +   
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 188

Query: 642 VSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAAL 701
            + LLQ   +P+   ++G+TPLH+A           LL   A+V+   + G TP H+A+ 
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248

Query: 702 KGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
           +GN  ++++L++ GAQ++ +     TPL  A R+    I   L   G      T  G  P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  233 bits (594), Expect = 5e-61
 Identities = 138/385 (35%), Positives = 207/385 (53%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N ++PLH       VE V+ LL H+  VD  T    T L +AA      +  LLL   A
Sbjct: 309 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 368

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
           + N    +G+ PLH A +        LL+ +GA + A    G TP+H+AA     N+  L
Sbjct: 369 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLL 428

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+   A P++    G+T LH+AA  G V +V+ L   GA +DA+ R  +TPLH+A   GK
Sbjct: 429 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 488

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
              +Q LL+  A PDA   +GY PLH +A  G+  +  +LL  GA+  L T +G+TPLH+
Sbjct: 489 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 548

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  G L++  LL +  A   + G    TPLH+AA +  + V   LL+ GA P+A  ++G
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH+A +++       LL + A  +   K G TP HLA+ +G+T ++ +L++ GA + 
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 668

Query: 720 VQDGVSCTPLQLALRSRKQGIMSFL 744
           +      T L LA +  K  +   L
Sbjct: 669 MSTKSGLTSLHLAAQEDKVNVADIL 693



 Score =  223 bits (569), Expect = 4e-58
 Identities = 140/377 (37%), Positives = 204/377 (54%)

Query: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
           I E+ +TP+H     G +  V LLL +    D     G T L +AA+  Q ++   LL +
Sbjct: 406 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465

Query: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477
           GA  +    +   PLH A++ G     +LLL H A  DA    G+TPLH++A+    +VA
Sbjct: 466 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 525

Query: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537
            +L+   A  +L   +G TPLHVAA +G + + KLL  + A  D+  +N  TPLH+A   
Sbjct: 526 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 585

Query: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597
              +    LL+ GA P A  ++GY PLH AA + +  I   LL YGA   + T QG TPL
Sbjct: 586 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 645

Query: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657
           HLA+ +GH +++ LL +  AN+        T LHLAA+  +  V   L + GAD +A  +
Sbjct: 646 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 705

Query: 658 SGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQ 717
            G+TPL +A        V  LL+  ANV+A+ K G+TP H AA +G+T I+ VL++ GA+
Sbjct: 706 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 765

Query: 718 LDVQDGVSCTPLQLALR 734
            +       T L +A R
Sbjct: 766 PNATTANGNTALAIAKR 782



 Score =  221 bits (564), Expect = 2e-57
 Identities = 136/381 (35%), Positives = 202/381 (53%), Gaps = 8/381 (2%)

Query: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQ--------TASGYTPLLIAAQDQQPDLCAL 413
           ++  LH    +   +   LLL ++ + D Q        T SG+TPL IAA     ++  L
Sbjct: 171 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 230

Query: 414 LLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNF 473
           LL  GA  +    +G  PLH A++ G+    +LLLD G  +DA+ R+G TPLH AA++  
Sbjct: 231 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 290

Query: 474 ENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHL 533
           + V  LL+ R A        G +PLH+AA   HV  VK L    A +D    +  T LH+
Sbjct: 291 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 350

Query: 534 AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG 593
           A   G  R  + LL   A P+A   +G+ PLH A  + +  + ++L++YGAS++  T  G
Sbjct: 351 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410

Query: 594 WTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPN 653
            TP+H+AA+ GHL I+ LL ++ A+         T LH+AAR G+  VV  LL+ GA  +
Sbjct: 411 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 470

Query: 654 AAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVE 713
           A  +   TPLH+A +      V  LL+H A+  A    G+TP H++A +G   +  VL+E
Sbjct: 471 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 530

Query: 714 AGAQLDVQDGVSCTPLQLALR 734
           AGA   +      TPL +A +
Sbjct: 531 AGAAHSLATKKGFTPLHVAAK 551



 Score =  221 bits (564), Expect = 2e-57
 Identities = 138/402 (34%), Positives = 212/402 (52%), Gaps = 2/402 (0%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           E+  TPLH     G+V    LLL     VD    +G TPL +A++    ++  LLL  G 
Sbjct: 210 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 269

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
             +    DG  PLH AA++G D    LLL+ GA + A+ + G +PLH+AAQ +     + 
Sbjct: 270 QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 329

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+  +A  +    +  T LHVAA+ GH  + KLL  + A  +A+  N  TPLH+A ++ +
Sbjct: 330 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 389

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
           ++ ++ L+K GA   A+ +SG  P+H AA  G   I  +LL+ GAS ++   +G T LH+
Sbjct: 390 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 449

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  G +E++  L  + A + A      TPLH+A+R G+  +V  LLQ  A P+AA  +G
Sbjct: 450 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 509

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH++ +         LLE  A      K G+TP H+AA  G+  + K+L++  A  D
Sbjct: 510 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 569

Query: 720 VQDGVSCTPLQLALR--SRKQGIMSFLEGKEPSVATLGGSKP 759
                  TPL +A    ++K  ++   +G  P      G  P
Sbjct: 570 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTP 611



 Score =  221 bits (564), Expect = 2e-57
 Identities = 139/401 (34%), Positives = 205/401 (51%), Gaps = 2/401 (0%)

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           N +TPLH    +G+   V+LLL     +D +T  G TPL  AA+     +  LLL  GA 
Sbjct: 244 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 303

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
                ++G +PLH AAQ       + LL H A VD    +  T LH+AA      V +LL
Sbjct: 304 LLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 363

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
           + ++A+PN     G TPLH+A     + +++LL   GA + A   +  TP+H+A   G +
Sbjct: 364 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 423

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
             +  LL++GA PD  +  G   LH AA  G+  + + LLR GA ++    +  TPLH+A
Sbjct: 424 NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA 483

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
           +  G  EI+ LL +  A+  A     +TPLH++AR G+  V S LL+ GA  + A + G+
Sbjct: 484 SRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF 543

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLH+A +  +      LL+  A   +  K G TP H+AA   N  +  +L+E GA    
Sbjct: 544 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 603

Query: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
                 TPL +A +  +  I S L   G E ++ T  G  P
Sbjct: 604 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 644



 Score =  208 bits (530), Expect = 1e-53
 Identities = 139/426 (32%), Positives = 210/426 (49%), Gaps = 8/426 (1%)

Query: 334 GNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTA 393
           G+Y    L L  R N  P    L    N  TPLH    +  ++ + LL+ +   +   T 
Sbjct: 355 GHYRVTKLLLDKRAN--PNARAL----NGFTPLHIACKKNRIKVMELLVKYGASIQAITE 408

Query: 394 SGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGAC 453
           SG TP+ +AA     ++  LLL +GA  +  +  G   LH AA+ G     R LL +GA 
Sbjct: 409 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 468

Query: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513
           VDA+ RE  TPLH+A++     + +LL+   A P+     G TPLH++A  G V +  +L
Sbjct: 469 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528

Query: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
              GA      +   TPLH+A + G +   + LL+  A  D+  ++G  PLH AA     
Sbjct: 529 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 588

Query: 574 LICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633
            +  +LL  GAS       G+TPLH+AA K  ++I   L    A    +     TPLHLA
Sbjct: 589 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 648

Query: 634 ARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGW 693
           ++ G   +V+ LL  GA+ + + +SG T LHLA Q         L +H A+  A  K+G+
Sbjct: 649 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 708

Query: 694 TPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSV 751
           TP  +A   GN  ++  L++ GA ++ +     TPL  A +     I++ L   G +P+ 
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768

Query: 752 ATLGGS 757
            T  G+
Sbjct: 769 TTANGN 774



 Score =  196 bits (499), Expect = 5e-50
 Identities = 132/413 (31%), Positives = 202/413 (48%), Gaps = 37/413 (8%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N +  LH    +G V  V+ LL     VD  T  G T L IA+   Q ++  +L+  GA
Sbjct: 41  QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA 100

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
           + N   ++G+ PL+ AAQ       + LL++GA       +G+TPL +A Q        +
Sbjct: 101 NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAI 160

Query: 480 LVSRQAD-----PNLHEA--------------------------------EGKTPLHVAA 502
           L+          P LH A                                 G TPLH+AA
Sbjct: 161 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 220

Query: 503 YFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYG 562
           ++G+V++  LL ++GA +D   RN  TPLH+A +RG    ++ LL  G   DA  + G  
Sbjct: 221 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLT 280

Query: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGAL 622
           PLH AA  G   + ++LL  GA L   T  G +PLH+AA   H+E +  L +  A +  +
Sbjct: 281 PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDV 340

Query: 623 GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHH 682
                T LH+AA  G   V   LL   A+PNA   +G+TPLH+A +++    +  L+++ 
Sbjct: 341 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 400

Query: 683 ANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS 735
           A++ A  + G TP H+AA  G+  I+ +L++ GA  DV +    T L +A R+
Sbjct: 401 ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARA 453



 Score =  195 bits (496), Expect = 1e-49
 Identities = 122/353 (34%), Positives = 192/353 (54%), Gaps = 3/353 (0%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           T LH     G VE VR LL +   VD +     TPL IA++  + ++  LLL H A  + 
Sbjct: 445 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 504

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
              +G+ PLH +A+ G    A +LL+ GA      ++G+TPLH+AA+    +VA+LL+ R
Sbjct: 505 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 564

Query: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
           +A  +     G TPLHVAA++ +  +  LL  +GA   A  +N  TPLH+A ++ +++  
Sbjct: 565 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 624

Query: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
             LL  GA  + + + G  PLH A+  G   +  +LL  GA++ + T  G T LHLAA +
Sbjct: 625 STLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 684

Query: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663
             + +  +L +  A+  A   + +TPL +A  +G   +V+ LL+ GA+ NA  ++G+TPL
Sbjct: 685 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 744

Query: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAI---LKVLVE 713
           H A Q+     +  LL+H A  +A    G T   +A   G  ++   LKV+ E
Sbjct: 745 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE 797



 Score =  174 bits (442), Expect = 2e-43
 Identities = 107/285 (37%), Positives = 149/285 (52%)

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           N  TPLH    +G V+   +LL         T  G+TPL +AA+    D+  LLL   A 
Sbjct: 508 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 567

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
           A+   ++G  PLH AA   +   A LLL+ GA   A  + G+TPLH+AA+ N   +A  L
Sbjct: 568 ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 627

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
           ++  A+ N+   +G TPLH+A+  GH  +V LL  +GA +    ++  T LHLA +  KV
Sbjct: 628 LNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKV 687

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
                L K GA  DA  + GY PL  A   G   +   LL+ GA++   T  G+TPLH A
Sbjct: 688 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 747

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
           A +GH  II++L +  A   A  A   T L +A R G  +VV  L
Sbjct: 748 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792



 Score =  159 bits (402), Expect = 9e-39
 Identities = 115/391 (29%), Positives = 180/391 (46%), Gaps = 37/391 (9%)

Query: 391 QTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDH 450
           Q +      L AA+    D     L  G D N  +++G   LH AA+ G  G  + LL  
Sbjct: 6   QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65

Query: 451 GACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV 510
           G+ VD+  ++G T LH+A+      V ++LV   A+ N     G TPL++AA   H+ +V
Sbjct: 66  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125

Query: 511 KLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL----------------------- 547
           K L   GA       +  TPL +A+++G  +A+  LL                       
Sbjct: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185

Query: 548 --------------KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG 593
                         +S  + +   +SG+ PLH AA  G   +  +LL  GA+++     G
Sbjct: 186 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245

Query: 594 WTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPN 653
            TPLH+A+ +G+  ++ LL +    + A      TPLH AAR G + VV  LL+ GA   
Sbjct: 246 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL 305

Query: 654 AAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVE 713
           A  ++G +PLH+A Q      V +LL+H A V        T  H+AA  G+  + K+L++
Sbjct: 306 ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 365

Query: 714 AGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
             A  + +     TPL +A +  +  +M  L
Sbjct: 366 KRANPNARALNGFTPLHIACKKNRIKVMELL 396



 Score =  141 bits (355), Expect = 3e-33
 Identities = 83/212 (39%), Positives = 113/212 (53%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N +TPLH      + +   LLL           +GYTPL IAA+  Q  + + LL +GA
Sbjct: 573 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 632

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
           + N V + G  PLH A+Q G      LLLD GA +    + G T LHLAAQ +  NVA +
Sbjct: 633 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 692

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L    AD + H   G TPL VA ++G+V +V  L  QGA ++A+ +N  TPLH A ++G 
Sbjct: 693 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 752

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARG 571
              I  LL+ GA P+A   +G   L  A   G
Sbjct: 753 THIINVLLQHGAKPNATTANGNTALAIAKRLG 784



 Score =  137 bits (346), Expect = 3e-32
 Identities = 102/305 (33%), Positives = 147/305 (48%), Gaps = 15/305 (4%)

Query: 465 LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ 524
           L  A   N + V   L     D N     G   LH+AA  GHV LV+ L  +G+ +D+  
Sbjct: 15  LRAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 73

Query: 525 RNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGA 584
           +   T LH+A   G+   ++ L+K GA  +A  Q+G+ PL+ AA      + K LL  GA
Sbjct: 74  KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 133

Query: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644
           +    T  G+TPL +A  +GH + + +L E+       G V    LH+AAR  +    + 
Sbjct: 134 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAAL 189

Query: 645 LLQ--CGAD------PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPA 696
           LLQ    AD       N   +SG+TPLH+A           LL   A V    + G TP 
Sbjct: 190 LLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPL 249

Query: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS-RKQGIMSFLEGKEPSVA-TL 754
           H+A+ +GNT ++K+L++ G Q+D +     TPL  A RS   Q +   LE   P +A T 
Sbjct: 250 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309

Query: 755 GGSKP 759
            G  P
Sbjct: 310 NGLSP 314


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  233 bits (594), Expect = 5e-61
 Identities = 138/385 (35%), Positives = 207/385 (53%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N ++PLH       VE V+ LL H+  VD  T    T L +AA      +  LLL   A
Sbjct: 330 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 389

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
           + N    +G+ PLH A +        LL+ +GA + A    G TP+H+AA     N+  L
Sbjct: 390 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLL 449

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+   A P++    G+T LH+AA  G V +V+ L   GA +DA+ R  +TPLH+A   GK
Sbjct: 450 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 509

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
              +Q LL+  A PDA   +GY PLH +A  G+  +  +LL  GA+  L T +G+TPLH+
Sbjct: 510 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  G L++  LL +  A   + G    TPLH+AA +  + V   LL+ GA P+A  ++G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH+A +++       LL + A  +   K G TP HLA+ +G+T ++ +L++ GA + 
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689

Query: 720 VQDGVSCTPLQLALRSRKQGIMSFL 744
           +      T L LA +  K  +   L
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADIL 714



 Score =  223 bits (569), Expect = 4e-58
 Identities = 140/377 (37%), Positives = 204/377 (54%)

Query: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
           I E+ +TP+H     G +  V LLL +    D     G T L +AA+  Q ++   LL +
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486

Query: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477
           GA  +    +   PLH A++ G     +LLL H A  DA    G+TPLH++A+    +VA
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546

Query: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537
            +L+   A  +L   +G TPLHVAA +G + + KLL  + A  D+  +N  TPLH+A   
Sbjct: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 606

Query: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597
              +    LL+ GA P A  ++GY PLH AA + +  I   LL YGA   + T QG TPL
Sbjct: 607 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666

Query: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657
           HLA+ +GH +++ LL +  AN+        T LHLAA+  +  V   L + GAD +A  +
Sbjct: 667 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 726

Query: 658 SGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQ 717
            G+TPL +A        V  LL+  ANV+A+ K G+TP H AA +G+T I+ VL++ GA+
Sbjct: 727 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786

Query: 718 LDVQDGVSCTPLQLALR 734
            +       T L +A R
Sbjct: 787 PNATTANGNTALAIAKR 803



 Score =  221 bits (564), Expect = 2e-57
 Identities = 136/381 (35%), Positives = 202/381 (53%), Gaps = 8/381 (2%)

Query: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQ--------TASGYTPLLIAAQDQQPDLCAL 413
           ++  LH    +   +   LLL ++ + D Q        T SG+TPL IAA     ++  L
Sbjct: 192 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 251

Query: 414 LLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNF 473
           LL  GA  +    +G  PLH A++ G+    +LLLD G  +DA+ R+G TPLH AA++  
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311

Query: 474 ENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHL 533
           + V  LL+ R A        G +PLH+AA   HV  VK L    A +D    +  T LH+
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 371

Query: 534 AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG 593
           A   G  R  + LL   A P+A   +G+ PLH A  + +  + ++L++YGAS++  T  G
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431

Query: 594 WTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPN 653
            TP+H+AA+ GHL I+ LL ++ A+         T LH+AAR G+  VV  LL+ GA  +
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491

Query: 654 AAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVE 713
           A  +   TPLH+A +      V  LL+H A+  A    G+TP H++A +G   +  VL+E
Sbjct: 492 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551

Query: 714 AGAQLDVQDGVSCTPLQLALR 734
           AGA   +      TPL +A +
Sbjct: 552 AGAAHSLATKKGFTPLHVAAK 572



 Score =  221 bits (564), Expect = 2e-57
 Identities = 138/402 (34%), Positives = 212/402 (52%), Gaps = 2/402 (0%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           E+  TPLH     G+V    LLL     VD    +G TPL +A++    ++  LLL  G 
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 290

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
             +    DG  PLH AA++G D    LLL+ GA + A+ + G +PLH+AAQ +     + 
Sbjct: 291 QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+  +A  +    +  T LHVAA+ GH  + KLL  + A  +A+  N  TPLH+A ++ +
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 410

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
           ++ ++ L+K GA   A+ +SG  P+H AA  G   I  +LL+ GAS ++   +G T LH+
Sbjct: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  G +E++  L  + A + A      TPLH+A+R G+  +V  LLQ  A P+AA  +G
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH++ +         LLE  A      K G+TP H+AA  G+  + K+L++  A  D
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590

Query: 720 VQDGVSCTPLQLALR--SRKQGIMSFLEGKEPSVATLGGSKP 759
                  TPL +A    ++K  ++   +G  P      G  P
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTP 632



 Score =  221 bits (564), Expect = 2e-57
 Identities = 139/401 (34%), Positives = 205/401 (51%), Gaps = 2/401 (0%)

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           N +TPLH    +G+   V+LLL     +D +T  G TPL  AA+     +  LLL  GA 
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
                ++G +PLH AAQ       + LL H A VD    +  T LH+AA      V +LL
Sbjct: 325 LLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
           + ++A+PN     G TPLH+A     + +++LL   GA + A   +  TP+H+A   G +
Sbjct: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
             +  LL++GA PD  +  G   LH AA  G+  + + LLR GA ++    +  TPLH+A
Sbjct: 445 NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA 504

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
           +  G  EI+ LL +  A+  A     +TPLH++AR G+  V S LL+ GA  + A + G+
Sbjct: 505 SRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF 564

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLH+A +  +      LL+  A   +  K G TP H+AA   N  +  +L+E GA    
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624

Query: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
                 TPL +A +  +  I S L   G E ++ T  G  P
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 665



 Score =  208 bits (530), Expect = 1e-53
 Identities = 139/426 (32%), Positives = 210/426 (49%), Gaps = 8/426 (1%)

Query: 334 GNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTA 393
           G+Y    L L  R N  P    L    N  TPLH    +  ++ + LL+ +   +   T 
Sbjct: 376 GHYRVTKLLLDKRAN--PNARAL----NGFTPLHIACKKNRIKVMELLVKYGASIQAITE 429

Query: 394 SGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGAC 453
           SG TP+ +AA     ++  LLL +GA  +  +  G   LH AA+ G     R LL +GA 
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489

Query: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513
           VDA+ RE  TPLH+A++     + +LL+   A P+     G TPLH++A  G V +  +L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549

Query: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
              GA      +   TPLH+A + G +   + LL+  A  D+  ++G  PLH AA     
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609

Query: 574 LICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633
            +  +LL  GAS       G+TPLH+AA K  ++I   L    A    +     TPLHLA
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669

Query: 634 ARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGW 693
           ++ G   +V+ LL  GA+ + + +SG T LHLA Q         L +H A+  A  K+G+
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729

Query: 694 TPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSV 751
           TP  +A   GN  ++  L++ GA ++ +     TPL  A +     I++ L   G +P+ 
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789

Query: 752 ATLGGS 757
            T  G+
Sbjct: 790 TTANGN 795



 Score =  195 bits (496), Expect = 1e-49
 Identities = 122/353 (34%), Positives = 192/353 (54%), Gaps = 3/353 (0%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           T LH     G VE VR LL +   VD +     TPL IA++  + ++  LLL H A  + 
Sbjct: 466 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
              +G+ PLH +A+ G    A +LL+ GA      ++G+TPLH+AA+    +VA+LL+ R
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585

Query: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
           +A  +     G TPLHVAA++ +  +  LL  +GA   A  +N  TPLH+A ++ +++  
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 645

Query: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
             LL  GA  + + + G  PLH A+  G   +  +LL  GA++ + T  G T LHLAA +
Sbjct: 646 STLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 705

Query: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663
             + +  +L +  A+  A   + +TPL +A  +G   +V+ LL+ GA+ NA  ++G+TPL
Sbjct: 706 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765

Query: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAI---LKVLVE 713
           H A Q+     +  LL+H A  +A    G T   +A   G  ++   LKV+ E
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE 818



 Score =  174 bits (442), Expect = 2e-43
 Identities = 107/285 (37%), Positives = 149/285 (52%)

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           N  TPLH    +G V+   +LL         T  G+TPL +AA+    D+  LLL   A 
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 588

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
           A+   ++G  PLH AA   +   A LLL+ GA   A  + G+TPLH+AA+ N   +A  L
Sbjct: 589 ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
           ++  A+ N+   +G TPLH+A+  GH  +V LL  +GA +    ++  T LHLA +  KV
Sbjct: 649 LNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKV 708

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
                L K GA  DA  + GY PL  A   G   +   LL+ GA++   T  G+TPLH A
Sbjct: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
           A +GH  II++L +  A   A  A   T L +A R G  +VV  L
Sbjct: 769 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  166 bits (421), Expect = 6e-41
 Identities = 141/488 (28%), Positives = 219/488 (44%), Gaps = 87/488 (17%)

Query: 320 VNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQ--GSVEQ 377
           +NED +Q+   SDSG     + Q   R    P+  +        +   FL A   G++++
Sbjct: 2   MNEDAAQK---SDSGEKFNGSSQRRKR----PKKSD--------SNASFLRAARAGNLDK 46

Query: 378 VRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQ 437
           V   L   +D++    +G   L +AA++    L   LL  G+  +   + G   LH A+ 
Sbjct: 47  VVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASL 106

Query: 438 NGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTP 497
            G     ++L+  GA ++AQ + G+TPL++AAQ N  +V + L+   A+ +    +G TP
Sbjct: 107 AGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166

Query: 498 LHVAAYFGHVSLVKLL----------------------TSQGAEL-------DAQQRNL- 527
           L VA   GH   V +L                      T   A L       D Q + + 
Sbjct: 167 LAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMV 226

Query: 528 -------RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLL 580
                   TPLH+A   G V     LL  GA  D   ++G  PLH A+ RG   + K+LL
Sbjct: 227 NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 286

Query: 581 RYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEA 640
             G  ++  T  G TPLH AA  GH +++ LL E  A + A      +PLH+AA+     
Sbjct: 287 DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 346

Query: 641 VVSALLQ---------------------CG------------ADPNAAEQSGWTPLHLAV 667
            V  LLQ                     CG            A+PNA   +G+TPLH+A 
Sbjct: 347 CVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIAC 406

Query: 668 QRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCT 727
           +++    +  L+++ A++ A  + G TP H+AA  G+  I+ +L++ GA  DV +    T
Sbjct: 407 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466

Query: 728 PLQLALRS 735
            L +A R+
Sbjct: 467 ALHMAARA 474



 Score =  158 bits (400), Expect = 2e-38
 Identities = 114/382 (29%), Positives = 178/382 (46%), Gaps = 37/382 (9%)

Query: 400 LIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQER 459
           L AA+    D     L  G D N  +++G   LH AA+ G  G  + LL  G+ VD+  +
Sbjct: 36  LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95

Query: 460 EGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAE 519
           +G T LH+A+      V ++LV   A+ N     G TPL++AA   H+ +VK L   GA 
Sbjct: 96  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155

Query: 520 LDAQQRNLRTPLHLAVERGKVRAIQHLL-------------------------------- 547
                 +  TPL +A+++G  +A+  LL                                
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 215

Query: 548 -----KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY 602
                +S  + +   +SG+ PLH AA  G   +  +LL  GA+++     G TPLH+A+ 
Sbjct: 216 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK 275

Query: 603 KGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662
           +G+  ++ LL +    + A      TPLH AAR G + VV  LL+ GA   A  ++G +P
Sbjct: 276 RGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 335

Query: 663 LHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722
           LH+A Q      V +LL+H A V        T  H+AA  G+  + K+L++  A  + + 
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395

Query: 723 GVSCTPLQLALRSRKQGIMSFL 744
               TPL +A +  +  +M  L
Sbjct: 396 LNGFTPLHIACKKNRIKVMELL 417



 Score =  141 bits (355), Expect = 3e-33
 Identities = 83/212 (39%), Positives = 113/212 (53%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N +TPLH      + +   LLL           +GYTPL IAA+  Q  + + LL +GA
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
           + N V + G  PLH A+Q G      LLLD GA +    + G T LHLAAQ +  NVA +
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L    AD + H   G TPL VA ++G+V +V  L  QGA ++A+ +N  TPLH A ++G 
Sbjct: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARG 571
              I  LL+ GA P+A   +G   L  A   G
Sbjct: 774 THIINVLLQHGAKPNATTANGNTALAIAKRLG 805



 Score =  137 bits (346), Expect = 3e-32
 Identities = 102/305 (33%), Positives = 147/305 (48%), Gaps = 15/305 (4%)

Query: 465 LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ 524
           L  A   N + V   L     D N     G   LH+AA  GHV LV+ L  +G+ +D+  
Sbjct: 36  LRAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 94

Query: 525 RNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGA 584
           +   T LH+A   G+   ++ L+K GA  +A  Q+G+ PL+ AA      + K LL  GA
Sbjct: 95  KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154

Query: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644
           +    T  G+TPL +A  +GH + + +L E+       G V    LH+AAR  +    + 
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAAL 210

Query: 645 LLQ--CGAD------PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPA 696
           LLQ    AD       N   +SG+TPLH+A           LL   A V    + G TP 
Sbjct: 211 LLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPL 270

Query: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS-RKQGIMSFLEGKEPSVA-TL 754
           H+A+ +GNT ++K+L++ G Q+D +     TPL  A RS   Q +   LE   P +A T 
Sbjct: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330

Query: 755 GGSKP 759
            G  P
Sbjct: 331 NGLSP 335


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  233 bits (594), Expect = 5e-61
 Identities = 138/385 (35%), Positives = 207/385 (53%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N ++PLH       VE V+ LL H+  VD  T    T L +AA      +  LLL   A
Sbjct: 330 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 389

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
           + N    +G+ PLH A +        LL+ +GA + A    G TP+H+AA     N+  L
Sbjct: 390 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLL 449

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+   A P++    G+T LH+AA  G V +V+ L   GA +DA+ R  +TPLH+A   GK
Sbjct: 450 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 509

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
              +Q LL+  A PDA   +GY PLH +A  G+  +  +LL  GA+  L T +G+TPLH+
Sbjct: 510 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  G L++  LL +  A   + G    TPLH+AA +  + V   LL+ GA P+A  ++G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH+A +++       LL + A  +   K G TP HLA+ +G+T ++ +L++ GA + 
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689

Query: 720 VQDGVSCTPLQLALRSRKQGIMSFL 744
           +      T L LA +  K  +   L
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADIL 714



 Score =  223 bits (569), Expect = 4e-58
 Identities = 140/377 (37%), Positives = 204/377 (54%)

Query: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
           I E+ +TP+H     G +  V LLL +    D     G T L +AA+  Q ++   LL +
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486

Query: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477
           GA  +    +   PLH A++ G     +LLL H A  DA    G+TPLH++A+    +VA
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546

Query: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537
            +L+   A  +L   +G TPLHVAA +G + + KLL  + A  D+  +N  TPLH+A   
Sbjct: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHY 606

Query: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597
              +    LL+ GA P A  ++GY PLH AA + +  I   LL YGA   + T QG TPL
Sbjct: 607 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666

Query: 598 HLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657
           HLA+ +GH +++ LL +  AN+        T LHLAA+  +  V   L + GAD +A  +
Sbjct: 667 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK 726

Query: 658 SGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQ 717
            G+TPL +A        V  LL+  ANV+A+ K G+TP H AA +G+T I+ VL++ GA+
Sbjct: 727 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786

Query: 718 LDVQDGVSCTPLQLALR 734
            +       T L +A R
Sbjct: 787 PNATTANGNTALAIAKR 803



 Score =  221 bits (564), Expect = 2e-57
 Identities = 136/381 (35%), Positives = 202/381 (53%), Gaps = 8/381 (2%)

Query: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQ--------TASGYTPLLIAAQDQQPDLCAL 413
           ++  LH    +   +   LLL ++ + D Q        T SG+TPL IAA     ++  L
Sbjct: 192 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 251

Query: 414 LLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNF 473
           LL  GA  +    +G  PLH A++ G+    +LLLD G  +DA+ R+G TPLH AA++  
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311

Query: 474 ENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHL 533
           + V  LL+ R A        G +PLH+AA   HV  VK L    A +D    +  T LH+
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 371

Query: 534 AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG 593
           A   G  R  + LL   A P+A   +G+ PLH A  + +  + ++L++YGAS++  T  G
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431

Query: 594 WTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPN 653
            TP+H+AA+ GHL I+ LL ++ A+         T LH+AAR G+  VV  LL+ GA  +
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491

Query: 654 AAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVE 713
           A  +   TPLH+A +      V  LL+H A+  A    G+TP H++A +G   +  VL+E
Sbjct: 492 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551

Query: 714 AGAQLDVQDGVSCTPLQLALR 734
           AGA   +      TPL +A +
Sbjct: 552 AGAAHSLATKKGFTPLHVAAK 572



 Score =  221 bits (564), Expect = 2e-57
 Identities = 138/402 (34%), Positives = 212/402 (52%), Gaps = 2/402 (0%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           E+  TPLH     G+V    LLL     VD    +G TPL +A++    ++  LLL  G 
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 290

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
             +    DG  PLH AA++G D    LLL+ GA + A+ + G +PLH+AAQ +     + 
Sbjct: 291 QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+  +A  +    +  T LHVAA+ GH  + KLL  + A  +A+  N  TPLH+A ++ +
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 410

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
           ++ ++ L+K GA   A+ +SG  P+H AA  G   I  +LL+ GAS ++   +G T LH+
Sbjct: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
           AA  G +E++  L  + A + A      TPLH+A+R G+  +V  LLQ  A P+AA  +G
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530

Query: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
           +TPLH++ +         LLE  A      K G+TP H+AA  G+  + K+L++  A  D
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590

Query: 720 VQDGVSCTPLQLALR--SRKQGIMSFLEGKEPSVATLGGSKP 759
                  TPL +A    ++K  ++   +G  P      G  P
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTP 632



 Score =  221 bits (564), Expect = 2e-57
 Identities = 139/401 (34%), Positives = 205/401 (51%), Gaps = 2/401 (0%)

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           N +TPLH    +G+   V+LLL     +D +T  G TPL  AA+     +  LLL  GA 
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
                ++G +PLH AAQ       + LL H A VD    +  T LH+AA      V +LL
Sbjct: 325 LLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
           + ++A+PN     G TPLH+A     + +++LL   GA + A   +  TP+H+A   G +
Sbjct: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL 444

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
             +  LL++GA PD  +  G   LH AA  G+  + + LLR GA ++    +  TPLH+A
Sbjct: 445 NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA 504

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
           +  G  EI+ LL +  A+  A     +TPLH++AR G+  V S LL+ GA  + A + G+
Sbjct: 505 SRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF 564

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLH+A +  +      LL+  A   +  K G TP H+AA   N  +  +L+E GA    
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624

Query: 721 QDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
                 TPL +A +  +  I S L   G E ++ T  G  P
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 665



 Score =  208 bits (530), Expect = 1e-53
 Identities = 139/426 (32%), Positives = 210/426 (49%), Gaps = 8/426 (1%)

Query: 334 GNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTA 393
           G+Y    L L  R N  P    L    N  TPLH    +  ++ + LL+ +   +   T 
Sbjct: 376 GHYRVTKLLLDKRAN--PNARAL----NGFTPLHIACKKNRIKVMELLVKYGASIQAITE 429

Query: 394 SGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGAC 453
           SG TP+ +AA     ++  LLL +GA  +  +  G   LH AA+ G     R LL +GA 
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489

Query: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513
           VDA+ RE  TPLH+A++     + +LL+   A P+     G TPLH++A  G V +  +L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549

Query: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
              GA      +   TPLH+A + G +   + LL+  A  D+  ++G  PLH AA     
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609

Query: 574 LICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633
            +  +LL  GAS       G+TPLH+AA K  ++I   L    A    +     TPLHLA
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669

Query: 634 ARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGW 693
           ++ G   +V+ LL  GA+ + + +SG T LHLA Q         L +H A+  A  K+G+
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729

Query: 694 TPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSV 751
           TP  +A   GN  ++  L++ GA ++ +     TPL  A +     I++ L   G +P+ 
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789

Query: 752 ATLGGS 757
            T  G+
Sbjct: 790 TTANGN 795



 Score =  195 bits (496), Expect = 1e-49
 Identities = 122/353 (34%), Positives = 192/353 (54%), Gaps = 3/353 (0%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           T LH     G VE VR LL +   VD +     TPL IA++  + ++  LLL H A  + 
Sbjct: 466 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
              +G+ PLH +A+ G    A +LL+ GA      ++G+TPLH+AA+    +VA+LL+ R
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585

Query: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
           +A  +     G TPLHVAA++ +  +  LL  +GA   A  +N  TPLH+A ++ +++  
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 645

Query: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
             LL  GA  + + + G  PLH A+  G   +  +LL  GA++ + T  G T LHLAA +
Sbjct: 646 STLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 705

Query: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663
             + +  +L +  A+  A   + +TPL +A  +G   +V+ LL+ GA+ NA  ++G+TPL
Sbjct: 706 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765

Query: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAI---LKVLVE 713
           H A Q+     +  LL+H A  +A    G T   +A   G  ++   LKV+ E
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE 818



 Score =  174 bits (442), Expect = 2e-43
 Identities = 107/285 (37%), Positives = 149/285 (52%)

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           N  TPLH    +G V+   +LL         T  G+TPL +AA+    D+  LLL   A 
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 588

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
           A+   ++G  PLH AA   +   A LLL+ GA   A  + G+TPLH+AA+ N   +A  L
Sbjct: 589 ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
           ++  A+ N+   +G TPLH+A+  GH  +V LL  +GA +    ++  T LHLA +  KV
Sbjct: 649 LNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKV 708

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
                L K GA  DA  + GY PL  A   G   +   LL+ GA++   T  G+TPLH A
Sbjct: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
           A +GH  II++L +  A   A  A   T L +A R G  +VV  L
Sbjct: 769 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  166 bits (421), Expect = 6e-41
 Identities = 141/488 (28%), Positives = 219/488 (44%), Gaps = 87/488 (17%)

Query: 320 VNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQ--GSVEQ 377
           +NED +Q+   SDSG     + Q   R    P+  +        +   FL A   G++++
Sbjct: 2   MNEDAAQK---SDSGEKFNGSSQRRKR----PKKSD--------SNASFLRAARAGNLDK 46

Query: 378 VRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQ 437
           V   L   +D++    +G   L +AA++    L   LL  G+  +   + G   LH A+ 
Sbjct: 47  VVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASL 106

Query: 438 NGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTP 497
            G     ++L+  GA ++AQ + G+TPL++AAQ N  +V + L+   A+ +    +G TP
Sbjct: 107 AGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166

Query: 498 LHVAAYFGHVSLVKLL----------------------TSQGAEL-------DAQQRNL- 527
           L VA   GH   V +L                      T   A L       D Q + + 
Sbjct: 167 LAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMV 226

Query: 528 -------RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLL 580
                   TPLH+A   G V     LL  GA  D   ++G  PLH A+ RG   + K+LL
Sbjct: 227 NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 286

Query: 581 RYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEA 640
             G  ++  T  G TPLH AA  GH +++ LL E  A + A      +PLH+AA+     
Sbjct: 287 DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 346

Query: 641 VVSALLQ---------------------CG------------ADPNAAEQSGWTPLHLAV 667
            V  LLQ                     CG            A+PNA   +G+TPLH+A 
Sbjct: 347 CVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIAC 406

Query: 668 QRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCT 727
           +++    +  L+++ A++ A  + G TP H+AA  G+  I+ +L++ GA  DV +    T
Sbjct: 407 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466

Query: 728 PLQLALRS 735
            L +A R+
Sbjct: 467 ALHMAARA 474



 Score =  158 bits (400), Expect = 2e-38
 Identities = 114/382 (29%), Positives = 178/382 (46%), Gaps = 37/382 (9%)

Query: 400 LIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQER 459
           L AA+    D     L  G D N  +++G   LH AA+ G  G  + LL  G+ VD+  +
Sbjct: 36  LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95

Query: 460 EGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAE 519
           +G T LH+A+      V ++LV   A+ N     G TPL++AA   H+ +VK L   GA 
Sbjct: 96  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155

Query: 520 LDAQQRNLRTPLHLAVERGKVRAIQHLL-------------------------------- 547
                 +  TPL +A+++G  +A+  LL                                
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 215

Query: 548 -----KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY 602
                +S  + +   +SG+ PLH AA  G   +  +LL  GA+++     G TPLH+A+ 
Sbjct: 216 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK 275

Query: 603 KGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662
           +G+  ++ LL +    + A      TPLH AAR G + VV  LL+ GA   A  ++G +P
Sbjct: 276 RGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 335

Query: 663 LHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722
           LH+A Q      V +LL+H A V        T  H+AA  G+  + K+L++  A  + + 
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395

Query: 723 GVSCTPLQLALRSRKQGIMSFL 744
               TPL +A +  +  +M  L
Sbjct: 396 LNGFTPLHIACKKNRIKVMELL 417



 Score =  141 bits (355), Expect = 3e-33
 Identities = 83/212 (39%), Positives = 113/212 (53%)

Query: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +N +TPLH      + +   LLL           +GYTPL IAA+  Q  + + LL +GA
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653

Query: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
           + N V + G  PLH A+Q G      LLLD GA +    + G T LHLAAQ +  NVA +
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L    AD + H   G TPL VA ++G+V +V  L  QGA ++A+ +N  TPLH A ++G 
Sbjct: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARG 571
              I  LL+ GA P+A   +G   L  A   G
Sbjct: 774 THIINVLLQHGAKPNATTANGNTALAIAKRLG 805



 Score =  137 bits (346), Expect = 3e-32
 Identities = 102/305 (33%), Positives = 147/305 (48%), Gaps = 15/305 (4%)

Query: 465 LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ 524
           L  A   N + V   L     D N     G   LH+AA  GHV LV+ L  +G+ +D+  
Sbjct: 36  LRAARAGNLDKVVEYLKGG-IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 94

Query: 525 RNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGA 584
           +   T LH+A   G+   ++ L+K GA  +A  Q+G+ PL+ AA      + K LL  GA
Sbjct: 95  KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154

Query: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644
           +    T  G+TPL +A  +GH + + +L E+       G V    LH+AAR  +    + 
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDDTKSAAL 210

Query: 645 LLQ--CGAD------PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPA 696
           LLQ    AD       N   +SG+TPLH+A           LL   A V    + G TP 
Sbjct: 211 LLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPL 270

Query: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS-RKQGIMSFLEGKEPSVA-TL 754
           H+A+ +GNT ++K+L++ G Q+D +     TPL  A RS   Q +   LE   P +A T 
Sbjct: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330

Query: 755 GGSKP 759
            G  P
Sbjct: 331 NGLSP 335


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  194 bits (492), Expect = 3e-49
 Identities = 180/666 (27%), Positives = 309/666 (46%), Gaps = 43/666 (6%)

Query: 19  DDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASSDVNY--LIEEAAKMK 76
           DD+      + SG F+ V + R +    +YA K        ++   V+   +  E + +K
Sbjct: 10  DDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILK 69

Query: 77  KIKFQHIVSIYGVC--KQPLGIVMEFMANGSLEKVLST-HSLCWKLRFRIIHETSLAMNF 133
           +I+  ++++++ V   K  + +++E +A G L   L+   SL  +     + +    + +
Sbjct: 70  EIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYY 129

Query: 134 LHSIKPPLLHLDLKPGNI-LLDSNM---HVKISDFGLSKWMEQSTRMQYIERSALRGMLS 189
           LHS++  + H DLKP NI LLD N+    +KI DFGL+  ++     + I      G   
Sbjct: 130 LHSLQ--IAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIF-----GTPE 182

Query: 190 YIPPEMFLESNKAP-GPKYDVYSFAIVIWELLTQKKPYSGFNMMMIIIRVAAGMRPSLQP 248
           ++ PE+    N  P G + D++S  ++ + LL+   P+ G      +  V+A        
Sbjct: 183 FVAPEIV---NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVN----YE 235

Query: 249 VSDQWPSEAQQMV-DLMKRCWDQDPKKRPCFLDITI-------ETDILLSLLQSRVAVPE 300
             D++ S    +  D ++R   +DPKKR    D          +T   LS   S V + +
Sbjct: 236 FEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEK 295

Query: 301 SKALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYE 360
            K  A +   K S+R    + + +S+  +   + +  +    L +  + V +     I +
Sbjct: 296 FKKFAARKKWKQSVRLIS-LCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAIND 354

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           + V  L  L+   S            DV+     G  PLLIAA      +  LL+  G+ 
Sbjct: 355 DNVPGLQHLLGSLS----------NYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSR 404

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
            +  D+ G   +++AA++G   T + L ++   +D +++ G   LH+AA+    +VA+LL
Sbjct: 405 IDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLL 464

Query: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
            S  ++PN+ + E +TPLH AA+ G+ S+ K L   G  ++ + R   TPL  A  RG  
Sbjct: 465 CSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYH 524

Query: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
             ++ L + GA  +A D+ G+  LH A  R +  + K LL  G  ++     G TPLH+A
Sbjct: 525 DIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVA 584

Query: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
              G++ I+  L E++ N+        TPLHLAA +G   VV  L   GA   A    G 
Sbjct: 585 CKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGK 644

Query: 661 TPLHLA 666
           T   LA
Sbjct: 645 TAEDLA 650



 Score =  131 bits (330), Expect = 2e-30
 Identities = 84/281 (29%), Positives = 135/281 (48%), Gaps = 1/281 (0%)

Query: 465 LHLAAQNNFENVARLLVS-RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQ 523
           +H    +N   +  LL S    D N     G  PL +AA  G++ +++LL  +G+ +D Q
Sbjct: 349 IHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQ 408

Query: 524 QRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYG 583
            +     ++ A   G V  ++ L ++    D  D+SG   LH AA  G   + ++L  +G
Sbjct: 409 DKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFG 468

Query: 584 ASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVS 643
           ++  +   +  TPLH AA+ G+  +   L E+  N+        TPL  A+  G   +V 
Sbjct: 469 SNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVE 528

Query: 644 ALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKG 703
            L + GAD NA ++ G   LHLAV+R     +  LL     V  +++ G TP H+A   G
Sbjct: 529 CLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDG 588

Query: 704 NTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
           N  I+  L EA   LD+ +    TPL LA  +    ++ +L
Sbjct: 589 NMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYL 629



 Score =  131 bits (330), Expect = 2e-30
 Identities = 86/291 (29%), Positives = 137/291 (47%)

Query: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513
           V+   + G  PL +AA      + +LL+ R +  ++ +  G   ++ AA  GHV  +K L
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431

Query: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
           +     LD + ++    LH+A   G     Q L   G+ P+  D+    PLH AA  G Y
Sbjct: 432 SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYY 491

Query: 574 LICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633
            + K L   G ++ +   +G TPL  A+ +G+ +I+  LAE  A++ A        LHLA
Sbjct: 492 SVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLA 551

Query: 634 ARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGW 693
            R  +  V+  LL  G   +  ++ G TPLH+A +      V+ L E + N+   NK G 
Sbjct: 552 VRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGR 611

Query: 694 TPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
           TP HLAA  G   +++ L   GA ++       T   LA   + + +   L
Sbjct: 612 TPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 53/183 (28%), Positives = 67/183 (36%), Gaps = 33/183 (18%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           TPLH     G     + L     +V+ +   G TPLL A+     D+   L  HGAD N 
Sbjct: 480 TPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNA 539

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREG---------------------- 461
            D+DG   LH A +       + LL  G  VD Q+R G                      
Sbjct: 540 CDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEA 599

Query: 462 -----------WTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV 510
                       TPLHLAA N   +V R L    A       +GKT   +A    H  + 
Sbjct: 600 NCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVA 659

Query: 511 KLL 513
            LL
Sbjct: 660 GLL 662


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  194 bits (492), Expect = 3e-49
 Identities = 126/357 (35%), Positives = 176/357 (49%), Gaps = 3/357 (0%)

Query: 366 LHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVD 425
           +H+    G +E V+LL++H  +V C+    YTPL  AA      +   LL  G D N  +
Sbjct: 177 IHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPN 236

Query: 426 EDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA-RLLVSRQ 484
             G  PLH A  NG D     L+D GA V+ +  +G+TPLH AA +    +   LLV   
Sbjct: 237 AYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNG 296

Query: 485 ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQ 544
           AD N+   +GKTPLH+ A  G  S  + +   GA +D + +N  TPLH+A   G    I 
Sbjct: 297 ADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLIN 356

Query: 545 HLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKG 604
            L+ SGA        G  PLH AA  G    C+ LL  G  ++ P   G T LH AA  G
Sbjct: 357 TLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGG 416

Query: 605 HLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLH 664
           +LE ++LL  + A+         +PLH AA +     + AL+  GA  N  ++ G TPLH
Sbjct: 417 NLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLH 476

Query: 665 LAVQRSTFLSVIN-LLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
            A    T    +  LL + AN   R+K G+   H +A  G+   L+ L+ +   LDV
Sbjct: 477 YAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQ-LIASETPLDV 532



 Score =  191 bits (486), Expect = 2e-48
 Identities = 120/367 (32%), Positives = 182/367 (49%), Gaps = 1/367 (0%)

Query: 370 VAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGW 429
           +  G  ++VR L+  + DV+ Q     TPL  AA     ++  LL+  GA  N  D    
Sbjct: 16  IFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWL 75

Query: 430 APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNL 489
            PLH A  +  +   ++LL H A V+A+++   TPLH+AA N     A  LV   ++ N+
Sbjct: 76  TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV 135

Query: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS 549
            +  G+T LH AA+ GH  +VKLL S+GA ++A  +  R  +H A   G +  ++ L+  
Sbjct: 136 SDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 195

Query: 550 GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEII 609
           GA     D+  Y PLH AA+ G   + K LL  G  +  P   G TPLH+A Y G   ++
Sbjct: 196 GAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVV 255

Query: 610 HLLAESHANMGALGAVNWTPLHLAARHGEEAV-VSALLQCGADPNAAEQSGWTPLHLAVQ 668
           + L +  A +       +TPLH AA     A+ +  L+  GAD N   + G TPLH+   
Sbjct: 256 NELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTAL 315

Query: 669 RSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTP 728
              F     +++  A +   +K G TP H+AA  G+  ++  L+ +GA    +      P
Sbjct: 316 HGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFP 375

Query: 729 LQLALRS 735
           L LA  S
Sbjct: 376 LHLAALS 382



 Score =  190 bits (482), Expect = 5e-48
 Identities = 124/386 (32%), Positives = 192/386 (49%), Gaps = 2/386 (0%)

Query: 349 LVPRDEELCIYEN-KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQ 407
           L+ + E++   +N K TPLH     G  E + LL+     V+ + +   TPL  A     
Sbjct: 27  LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86

Query: 408 PDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHL 467
            +   +LL H AD N  D++   PLH AA N     A  L+   + V+  +R G T LH 
Sbjct: 87  EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146

Query: 468 AAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL 527
           AA +    + +LL+SR A+ N  + + +  +H AAY GH+ +VKLL S GAE+  + +  
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206

Query: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLE 587
            TPLH A   G +  +++LL  G   +  +  G  PLH A   G+ ++   L+  GA + 
Sbjct: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266

Query: 588 LPTHQGWTPLHLAAYKGHLEI-IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALL 646
               +G+TPLH AA   H  + + LL  + A++        TPLH+ A HG  +    ++
Sbjct: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326

Query: 647 QCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTA 706
           Q GA  +  +++G TPLH+A +    L +  L+   A+   R   G  P HLAAL G + 
Sbjct: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386

Query: 707 ILKVLVEAGAQLDVQDGVSCTPLQLA 732
             + L+ +G  +D  D    T L  A
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAA 412



 Score =  186 bits (471), Expect = 9e-47
 Identities = 126/393 (32%), Positives = 190/393 (48%), Gaps = 1/393 (0%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
           +TPLH  VA  S E V++LL H  DV+ +  +  TPL IAA ++       L+   ++ N
Sbjct: 75  LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 134

Query: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482
             D  G   LH AA +G     +LLL  GA ++A +++    +H AA      V +LLVS
Sbjct: 135 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 194

Query: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542
             A+    + +  TPLH AA  G +S+VK L   G +++       TPLH+A   G+   
Sbjct: 195 HGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVV 254

Query: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLIC-KMLLRYGASLELPTHQGWTPLHLAA 601
           +  L+  GA+ +  ++ G+ PLH AAA     +C ++L+  GA + + +  G TPLH+ A
Sbjct: 255 VNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTA 314

Query: 602 YKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWT 661
             G       + +S A +        TPLH+AAR+G E +++ L+  GAD       G  
Sbjct: 315 LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMF 374

Query: 662 PLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
           PLHLA           LL    ++   +  G T  H AA  GN   L +L+  GA  + +
Sbjct: 375 PLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKK 434

Query: 722 DGVSCTPLQLALRSRKQGIMSFLEGKEPSVATL 754
           D    +PL  A  +     +  L G   SV  L
Sbjct: 435 DKFGRSPLHYAAANCNYQCLFALVGSGASVNDL 467



 Score =  174 bits (442), Expect = 2e-43
 Identities = 110/337 (32%), Positives = 172/337 (51%), Gaps = 1/337 (0%)

Query: 399 LLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQE 458
           L+ A  +  PD    L+    D N  D +   PLH AA  GD     LL+  GA V+A++
Sbjct: 12  LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 71

Query: 459 REGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGA 518
            +  TPLH A  +  E   ++L+   AD N  +   +TPLH+AA    V   + L    +
Sbjct: 72  SKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLS 131

Query: 519 ELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKM 578
            ++   R  RT LH A   G    ++ LL  GA  +A D+     +H AA  G   + K+
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191

Query: 579 LLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGE 638
           L+ +GA +     + +TPLH AA  G + ++  L +   +M    A   TPLH+A  +G+
Sbjct: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQ 251

Query: 639 EAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLL-EHHANVHARNKVGWTPAH 697
           + VV+ L+ CGA  N   + G+TPLH A   +     + LL  + A+V+ ++K G TP H
Sbjct: 252 DVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLH 311

Query: 698 LAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALR 734
           + AL G  +  + ++++GA +D +D    TPL +A R
Sbjct: 312 MTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAAR 348



 Score =  147 bits (372), Expect = 3e-35
 Identities = 133/480 (27%), Positives = 195/480 (40%), Gaps = 90/480 (18%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           T LH   A G++E + LLL    D + +   G +PL  AA +        L+  GA  N 
Sbjct: 407 TCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVND 466

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLL------------------------DHGACV----- 454
           +DE G  PLH+AA +  DG     L                         H  C+     
Sbjct: 467 LDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIAS 526

Query: 455 -----------------DAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTP 497
                            D+  R   +PLHLAA +       +LV    D ++  + G+TP
Sbjct: 527 ETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTP 586

Query: 498 LHVAAYFGHVSLVKLLTSQGAEL------------------------------------- 520
           L +AA+ GHV  V +L +QGA +                                     
Sbjct: 587 LDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAV 646

Query: 521 DAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLL 580
           D Q  N +TPL L+V  G    +  LL  GA  DA D+ G   LH  A  G       LL
Sbjct: 647 DIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALL 706

Query: 581 RYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAV----NWTPLHLAARH 636
           ++GA   L   +G TP+HL+A  GH+ ++  L +S A+M A  A      +T LH A  +
Sbjct: 707 QHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYN 766

Query: 637 GEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLE--HHANVHARNKVGWT 694
           G E  V  LL+        E + ++PLH AV      +   L++    + V+A +  G T
Sbjct: 767 GHETCVELLLEQEVF-QKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRT 825

Query: 695 PAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATL 754
           P H AA   +   L++L+   AQ++  D    TPL +A  + +   +  L     +  TL
Sbjct: 826 PLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTL 885



 Score =  142 bits (358), Expect = 1e-33
 Identities = 119/412 (28%), Positives = 183/412 (44%), Gaps = 46/412 (11%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
           ++PLH     G  + + +L+   +D+D + +SG TPL +AA     +   +L+  GA   
Sbjct: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610

Query: 423 RVDED-GWAPLHFAAQNGDDGTARLLLDHGA---CVDAQEREGWTPLHLAAQNNFENVAR 478
             D      P+H AA NG     RLL+ +      VD Q+  G TPL L+  N   +   
Sbjct: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670

Query: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG 538
            L+++ A+ +  +  G+T LH  A  GH   V  L   GA+   +    RTP+HL+   G
Sbjct: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730

Query: 539 KVRAIQHLLKSGAVPDA----LDQSGYGPLHTAAARGKYLICKMLLRY------------ 582
            +  +  LL+S A  DA     D  GY  LH A   G     ++LL              
Sbjct: 731 HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFS 790

Query: 583 ---------------------GASLELPTH-QGWTPLHLAAYKGHLEIIHLLAESHANMG 620
                                GAS+   T  +G TPLH AA+  H+E + LL   +A + 
Sbjct: 791 PLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850

Query: 621 ALGAVNWTPLHLAARHGEEAVVSALLQ-CGADPNAAEQSGWTPLHLAVQRSTFLSVINLL 679
           ++ +   TPL +AA +G+   V  L+    A+    + S  T LHLA  +    S + +L
Sbjct: 851 SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLIL 910

Query: 680 EHHAN---VHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTP 728
           E   +   ++A N    TP H+AA  G T +++ L+  GA +   D    TP
Sbjct: 911 EKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962



 Score =  140 bits (352), Expect = 6e-33
 Identities = 119/413 (28%), Positives = 184/413 (44%), Gaps = 50/413 (12%)

Query: 357 CIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA 416
           C  +N  TPLH     G    +  L+    D   +   G  PL +AA     D C  LL+
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393

Query: 417 HGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQN-NFEN 475
            G D +  D+ G   LH AA  G+     LLL+ GA  + +++ G +PLH AA N N++ 
Sbjct: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQC 453

Query: 476 VARL---------------------------------LVSRQADPNLHEAEGKTPLHVAA 502
           +  L                                 L+   A+P + + +G   +H +A
Sbjct: 454 LFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSA 513

Query: 503 YFGHVSLVKLLTSQ----------GAEL--DAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
            +GH   ++L+ S+          G ++  D+  R   +PLHLA   G  +A++ L++S 
Sbjct: 514 AYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL 573

Query: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTH-QGWTPLHLAAYKGHLEII 609
              D  + SG  PL  AA +G      +L+  GAS+ +  +    TP+H AA  GH E +
Sbjct: 574 LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECL 633

Query: 610 HLL---AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLA 666
            LL   AE    +        TPL L+  +G    V +LL  GA+ +A ++ G T LH  
Sbjct: 634 RLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRG 693

Query: 667 VQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
                   V  LL+H A    R+  G TP HL+A  G+  +L  L+++ A +D
Sbjct: 694 AVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMD 746



 Score =  135 bits (341), Expect = 1e-31
 Identities = 115/369 (31%), Positives = 166/369 (44%), Gaps = 14/369 (3%)

Query: 359 YENKVTPLHFLVAQGSVEQVRLLLAH---EVDVDCQTASGYTPLLIAAQDQQPDLCALLL 415
           Y  K TP+H     G  E +RLL+ +   +  VD Q  +G TPL+++  +   D    LL
Sbjct: 614 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673

Query: 416 AHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN 475
             GA+ +  D+ G   LH  A  G +     LL HGA    ++  G TP+HL+A      
Sbjct: 674 NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIG 733

Query: 476 VARLLV----SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPL 531
           V   L+    S  A+P   +  G T LH A Y GH + V+LL  Q       + N  +PL
Sbjct: 734 VLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQKTEGNAFSPL 792

Query: 532 HLAVERGKVRAIQHLLKS--GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP 589
           H AV      A + L+ +   ++ +A D  G  PLH AA        ++LL + A +   
Sbjct: 793 HCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSV 852

Query: 590 THQGWTPLHLAAYKGHLEIIHLLAES-HANMGALGAVNWTPLHLAARHGEEAVVSALLQC 648
              G TPL +AA  G    + +L  S  A +        T LHLA   G E     +L+ 
Sbjct: 853 DSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEK 912

Query: 649 GADPN---AAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNT 705
             D N   A   +  TPLH+A +    + V  LL   A+V A ++ G+TPA   A   + 
Sbjct: 913 ITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDV 972

Query: 706 AILKVLVEA 714
           A    L+ A
Sbjct: 973 ADCLALILA 981



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 59/183 (32%), Positives = 91/183 (49%), Gaps = 2/183 (1%)

Query: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGAL 622
           PLH AA  G   I ++L+  GA +     +  TPLH A      E + +L +  A++ A 
Sbjct: 44  PLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNAR 103

Query: 623 GAVNW-TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEH 681
              NW TPLH+AA +       AL+   ++ N ++++G T LH A        V  LL  
Sbjct: 104 DK-NWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 162

Query: 682 HANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIM 741
            AN++A +K      H AA  G+  ++K+LV  GA++  +D  S TPL  A  S    ++
Sbjct: 163 GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVV 222

Query: 742 SFL 744
            +L
Sbjct: 223 KYL 225



 Score = 37.4 bits (85), Expect = 0.053
 Identities = 27/101 (26%), Positives = 47/101 (46%)

Query: 636 HGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTP 695
           +G+   V AL+    D N  +    TPLH A        +  L+   A V+A++    TP
Sbjct: 18  NGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTP 77

Query: 696 AHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSR 736
            H A    +   ++VL++  A ++ +D    TPL +A  ++
Sbjct: 78  LHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANK 118


>gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo
           sapiens]
          Length = 540

 Score =  189 bits (481), Expect = 6e-48
 Identities = 127/367 (34%), Positives = 196/367 (53%), Gaps = 35/367 (9%)

Query: 24  DWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPP--DAASSDVNYLIEEAAKMKKIKFQ 81
           D R ++ G    V  ARH  WR + A+K      P  D+   DV   + EA  + K +F 
Sbjct: 20  DLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDV---LREAEILHKARFS 76

Query: 82  HIVSIYGVCKQP--LGIVMEFMANGSLEKVLSTHS----LCWKLRFRIIHETSLAMNFLH 135
           +I+ I G+C +P  LGIV E+M NGSL ++L   +    + W LRFRI+HE +L +N+LH
Sbjct: 77  YILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLH 136

Query: 136 SIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSALR-GMLSYIPPE 194
           ++ PPLLH DLK  NILLD+  HVKI+DFGLSKW   S       +SA   G + Y+PPE
Sbjct: 137 NMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPE 196

Query: 195 MFLESNKAPGP-KYDVYSFAIVIWELLTQKKPYSGF-NMMMIIIRVAAGMRPSLQPVSDQ 252
            +    K+    K+D+YS+A++ WE+L++K+P+    N + I+  V+ G RP +   S  
Sbjct: 197 NYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLP 256

Query: 253 W--PSEAQQMVDLMKRCWDQDPKKRPCFLDITIETDILL------SLLQSRVAVPESKA- 303
           +  P  A +M+ L++  W Q+P +RP FL   IE + +L      + L++ + + ++K  
Sbjct: 257 YDIPHRA-RMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQ 315

Query: 304 -------LARKVSCKLSLRQP---GEVNEDISQELMDSDSGN-YLKRALQLSDRKNLVPR 352
                  L  K   +LSL  P   G   E      +  +SG+    R+L      + + R
Sbjct: 316 SVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSR 375

Query: 353 DEELCIY 359
             + C +
Sbjct: 376 KAQDCYF 382


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  187 bits (474), Expect = 4e-47
 Identities = 125/370 (33%), Positives = 187/370 (50%), Gaps = 1/370 (0%)

Query: 365 PLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRV 424
           PL   +    VE+VR LL+ + +++       TPL  AA      +  LLL  GA+ N  
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 425 DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQ 484
           D     PLH AA + ++    LLL H A V+A+++   TPLH+AA N     A  L    
Sbjct: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130

Query: 485 ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQ 544
           +  N+ +  G++ LH A + GH+  V LL ++GA L+   +  R PLH A   G +  ++
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190

Query: 545 HLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKG 604
            L+  GA     D+ GYG LHTAAA G+  + K LLR GA ++ P   G T LH+A Y G
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250

Query: 605 HLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAV-VSALLQCGADPNAAEQSGWTPL 663
              +   L  + AN+       +TPLH+AA     A+ +  L+  GAD N   + G +PL
Sbjct: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310

Query: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723
           H+A     F     L+++ + +   +K G TP H+AA  G+  ++  L+  GA    +  
Sbjct: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGI 370

Query: 724 VSCTPLQLAL 733
               PL LA+
Sbjct: 371 HDMFPLHLAV 380



 Score =  174 bits (441), Expect = 3e-43
 Identities = 118/384 (30%), Positives = 193/384 (50%), Gaps = 7/384 (1%)

Query: 343 LSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIA 402
           LS ++N+   D+E      + TPLH     G V  ++LLL    +V+ +     TPL  A
Sbjct: 28  LSQKENINVLDQE------RRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRA 81

Query: 403 AQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGW 462
           A  +   +  LLLAH AD N  D+    PLH AA N     A  L    + ++  +R G 
Sbjct: 82  AASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGR 141

Query: 463 TPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDA 522
           + LH A  +       LL+++ A  N+ + + + PLH AA+ GH+ ++KLL ++GA+L  
Sbjct: 142 SALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGC 201

Query: 523 QQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRY 582
           + R     LH A   G++  +++LL+ GA  D  +  G   LH A   G+  +   L+  
Sbjct: 202 KDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNA 261

Query: 583 GASLELPTHQGWTPLHLAAYKGHLEI-IHLLAESHANMGALGAVNWTPLHLAARHGEEAV 641
           GA++  P  +G+TPLH+AA   +  + + LL  + A++        +PLH+AA HG    
Sbjct: 262 GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTR 321

Query: 642 VSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAAL 701
              L+Q G++ + A++ G TPLH+A +    L +  L+ + A+   R      P HLA L
Sbjct: 322 SQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVL 381

Query: 702 KGNTAILKVLVEAGAQLDVQDGVS 725
            G +   + L+ +G    +   +S
Sbjct: 382 FGFSDCCRKLLSSGQLYSIVSSLS 405



 Score =  172 bits (437), Expect = 8e-43
 Identities = 116/348 (33%), Positives = 180/348 (51%), Gaps = 1/348 (0%)

Query: 398 PLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQ 457
           PL+ A   +  +    LL+   + N +D++   PLH AA  GD    +LLL  GA V+A+
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 458 EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG 517
           +    TPLH AA +  E V  LL++  AD N  +   +TPLHVAA        + L    
Sbjct: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130

Query: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICK 577
           + L+   R+ R+ LH AV  G +  +  LL  GA  +  D+    PLH AA  G   + K
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190

Query: 578 MLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHG 637
           +L+  GA L     +G+  LH AA  G +E++  L    A +    A   T LH+A   G
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250

Query: 638 EEAVVSALLQCGADPNAAEQSGWTPLHLA-VQRSTFLSVINLLEHHANVHARNKVGWTPA 696
           ++AV   L+  GA+ N     G+TPLH+A V  +  L +  L+ + A+V+ ++K G +P 
Sbjct: 251 QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310

Query: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
           H+AA+ G     ++L++ G+++D  D    TPL +A R   + ++S L
Sbjct: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358



 Score =  150 bits (379), Expect = 4e-36
 Identities = 123/391 (31%), Positives = 178/391 (45%), Gaps = 37/391 (9%)

Query: 366 LHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVD 425
           L+ +V+  S E V   L+   D++     G T L  AA     +   LLL+ GAD  R D
Sbjct: 397 LYSIVSSLSNEHV---LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRD 453

Query: 426 EDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVAR------- 478
           + G  PLH+AA NG    A  L+  GA V+  + +G +PLH AA ++    A        
Sbjct: 454 KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSH 513

Query: 479 ---------------------LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG 517
                                 L+   ADP+L + +G T +H AA +G+   ++LL    
Sbjct: 514 DAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMS 573

Query: 518 AEL--DAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLI 575
                D +     +PLHLA   G   A++ L ++    D  D  G   L  A  RG    
Sbjct: 574 FNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTEC 633

Query: 576 CKMLLRYGASLELPTHQG-WTPLHLAAYKGHLEIIHLLAESHANMG---ALGAVNWTPLH 631
            ++L  +GAS  +   +  WTPLH AA  GH + +HLL +S         + A   TPL 
Sbjct: 634 VEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLM 693

Query: 632 LAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKV 691
           LA  +G    V  LL+ G+  +AA+  G T LH          +  LL+H A V  R+  
Sbjct: 694 LAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFK 753

Query: 692 GWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722
           G TP HLA+  G+TA+L+ L++A    D  D
Sbjct: 754 GRTPIHLASACGHTAVLRTLLQAALSTDPLD 784



 Score =  146 bits (368), Expect = 8e-35
 Identities = 126/423 (29%), Positives = 185/423 (43%), Gaps = 53/423 (12%)

Query: 364 TPLHFL-VAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
           TPLH   V+      + LL+ +  DV+ Q+  G +PL +AA   +     +L+ +G++ +
Sbjct: 274 TPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEID 333

Query: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482
             D+ G  PLH AA+ G +     L+ +GA    +      PLHLA    F +  R L+S
Sbjct: 334 CADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLS 393

Query: 483 RQA------------------DPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ 524
                                D N  +  G+T LH AA  G+V  + LL S GA+L  + 
Sbjct: 394 SGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRD 453

Query: 525 RNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY----------- 573
           +  RTPLH A   G  +    L+ +GA  +  D  G  PLH AAA   Y           
Sbjct: 454 KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSH 513

Query: 574 -----------------LICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESH 616
                               + LL  GA   L   QG+T +H AA  G+ + + LL E  
Sbjct: 514 DAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMS 573

Query: 617 ANM--GALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLS 674
            N        +  +PLHLAA +G    +  L +   + +  +  G T L LA +R +   
Sbjct: 574 FNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTEC 633

Query: 675 VINLLEHHANVHAR-NKVGWTPAHLAALKGNTAILKVLVEAGAQ---LDVQDGVSCTPLQ 730
           V  L  H A+   +  K  WTP H AA  G+T  L +L+++G +    DV D    TPL 
Sbjct: 634 VEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLM 693

Query: 731 LAL 733
           LA+
Sbjct: 694 LAI 696



 Score =  142 bits (357), Expect = 2e-33
 Identities = 119/382 (31%), Positives = 177/382 (46%), Gaps = 14/382 (3%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDV--DCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421
           T +H+  A G+ + + LLL    +   D ++    +PL +AA +   +    L     + 
Sbjct: 552 TAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNL 611

Query: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREG-WTPLHLAAQNNFENVARLL 480
           +  D  G   L  A + G      +L  HGA    +ER+  WTPLH AA +   +   LL
Sbjct: 612 DVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLL 671

Query: 481 VS--RQAD-PNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537
           +    +AD  ++ +A G+TPL +A   GHV  V LL  +G+  DA     RT LH     
Sbjct: 672 IDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVT 731

Query: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLEL----PTHQG 593
           G    +  LL   A     D  G  P+H A+A G   + + LL+   S +       + G
Sbjct: 732 GCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSG 791

Query: 594 WTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQC-GAD- 651
           ++P+H A+Y GH + + LL E H+    L    +TPLH A  + +++    LL   GA  
Sbjct: 792 YSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKI 850

Query: 652 PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVL 711
            N+ +  G TPLH A        +  LL+H A V+A +  G T    AA  G TA ++ L
Sbjct: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910

Query: 712 VEAG-AQLDVQDGVSCTPLQLA 732
           +  G A L V D    T L LA
Sbjct: 911 LYRGKADLTVLDENKNTALHLA 932



 Score =  132 bits (333), Expect = 9e-31
 Identities = 113/412 (27%), Positives = 175/412 (42%), Gaps = 46/412 (11%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADA- 421
           V+PLH     G  E ++ L    V++D +   G T L +A +    +   +L AHGA A 
Sbjct: 586 VSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645

Query: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGA---CVDAQEREGWTPLHLAAQNNFENVAR 478
            +  +  W PLH AA +G   +  LL+D G      D  +  G TPL LA  N   +   
Sbjct: 646 IKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVH 705

Query: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG 538
           LL+ + +  +  +  G+T LH  A  G    +  L    A +  +    RTP+HLA   G
Sbjct: 706 LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACG 765

Query: 539 KVRAIQHLLKSGAVPDAL----DQSGYGPLHTAAARGKYLICKMLLRYGASLEL------ 588
               ++ LL++    D L    D SGY P+H A+  G     ++LL +     L      
Sbjct: 766 HTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFT 825

Query: 589 PTH----------------------------QGWTPLHLAAYKGHLEIIHLLAESHANMG 620
           P H                            +G TPLH AA+  ++  + +L +  A + 
Sbjct: 826 PLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVN 885

Query: 621 ALGAVNWTPLHLAARHGEEAVVSALLQCG-ADPNAAEQSGWTPLHLAVQRSTFLSVINLL 679
           A      T L  AA +G+ A V  LL  G AD    +++  T LHLA  +      + +L
Sbjct: 886 ATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMIL 945

Query: 680 EHHAN---VHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTP 728
               +   ++A N     P H+AA  G  ++++ L+  GA +   D    TP
Sbjct: 946 AETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997



 Score =  131 bits (330), Expect = 2e-30
 Identities = 114/366 (31%), Positives = 162/366 (44%), Gaps = 14/366 (3%)

Query: 360  ENKVTPLHFLVAQGSVEQVRLLL--AHEVDV-DCQTASGYTPLLIAAQDQQPDLCALLLA 416
            + K TPLH   A G  + + LL+      D+ D   A G TPL++A  +   D   LLL 
Sbjct: 650  KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLE 709

Query: 417  HGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENV 476
             G+ A+  D  G   LH  A  G +     LLDH A V  ++ +G TP+HLA+      V
Sbjct: 710  KGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAV 769

Query: 477  ARLLVSRQADPNLHEA----EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLH 532
             R L+      +  +A     G +P+H A+Y GH   ++LL  + +     + N  TPLH
Sbjct: 770  LRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLL-EHSPFSYLEGNPFTPLH 828

Query: 533  LAVERGKVRAIQHLLKS--GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPT 590
             AV   +    + LL +    + ++ D  G  PLH AA        +MLL++ A +    
Sbjct: 829  CAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATD 888

Query: 591  HQGWTPLHLAAYKGHLEIIH-LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCG 649
            H G T L  AA  G    +  LL    A++  L     T LHLA   G E     +L   
Sbjct: 889  HTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAET 948

Query: 650  AD---PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTA 706
             D    NA   +   PLH+A +      V  LL H A V A ++ G TPA   A   + A
Sbjct: 949  QDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVA 1008

Query: 707  ILKVLV 712
                L+
Sbjct: 1009 DCLALI 1014



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 49/156 (31%), Positives = 72/156 (46%)

Query: 596 PLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAA 655
           PL  A +   +E +  L     N+  L     TPLH AA  G+  ++  LL  GA+ NA 
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAG 715
           +    TPLH A        +  LL H A+V+AR+K+  TP H+AA    T   + L    
Sbjct: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130

Query: 716 AQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSV 751
           + L+V D    + L  A+ S     ++ L  K  S+
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASL 166



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 37/118 (31%), Positives = 56/118 (47%)

Query: 619 MGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINL 678
           MG L   +  PL  A    +   V +LL    + N  +Q   TPLH A        +  L
Sbjct: 1   MGILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLL 60

Query: 679 LEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSR 736
           L   ANV+A++ +  TP H AA   N  +L +L+   A ++ +D +  TPL +A  +R
Sbjct: 61  LMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANR 118


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  185 bits (470), Expect = 1e-46
 Identities = 116/372 (31%), Positives = 182/372 (48%), Gaps = 1/372 (0%)

Query: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421
           K TPLH     G  E + LL+     V+ +     TPL  A   +  +   +L+ H AD 
Sbjct: 16  KRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADV 75

Query: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
           N  D++   PLH AA N     A +++   + V+  +R G T LH AA N    +  LL+
Sbjct: 76  NARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLL 135

Query: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
           ++ A+ N  + + +  LH AAY GH+ +V LL + GAE+  + +   TPLH A   G++ 
Sbjct: 136 AKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQIN 195

Query: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAA 601
            ++HLL  G   D ++  G   LH A   G+  +   L+ YGA++  P + G+TPLH AA
Sbjct: 196 VVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAA 255

Query: 602 YKGHLEI-IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
              H  + + LL  + A++        +PLH+ A HG       L+Q G + +  ++ G 
Sbjct: 256 ASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315

Query: 661 TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
           TPLH+A +    L +  L    A+          P HLAAL  ++   + L+ +G ++D 
Sbjct: 316 TPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDT 375

Query: 721 QDGVSCTPLQLA 732
            D    T L  A
Sbjct: 376 PDKFGRTCLHAA 387



 Score =  174 bits (442), Expect = 2e-43
 Identities = 113/354 (31%), Positives = 176/354 (49%), Gaps = 2/354 (0%)

Query: 381 LLAHEV-DVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNG 439
           +L H+  DV+   +   TPL +AA     ++  LL+  GA  N  D     PLH A  + 
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 440 DDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLH 499
            +   ++L+ H A V+A+++   TPLH+AA N     A +++   +  N+ +  G+T LH
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 500 VAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559
            AA  GHV +V LL ++GA ++A  +  R  LH A   G +  +  L+  GA     D+ 
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180

Query: 560 GYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANM 619
           GY PLH AA+ G+  + K LL  G  ++     G T LH+A Y G   +++ L +  AN+
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240

Query: 620 GALGAVNWTPLHLAARHGEEAV-VSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINL 678
                  +TPLH AA     A+ +  L+  GAD N   + G +PLH+      F     L
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300

Query: 679 LEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732
           +++   +   +K G TP H+AA  G+  ++  L  +GA        S  PL LA
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLA 354



 Score =  173 bits (438), Expect = 6e-43
 Identities = 123/407 (30%), Positives = 187/407 (45%), Gaps = 34/407 (8%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQ---------------- 406
           +TPLH  VA  S E V++L+ H  DV+ +  +  TPL +AA ++                
Sbjct: 50  LTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVN 109

Query: 407 -----------------QPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLD 449
                              ++  LLLA GA+ N  D+     LH+AA  G      LL++
Sbjct: 110 VSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169

Query: 450 HGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSL 509
           HGA V  ++++G+TPLH AA N   NV + L++   + +     G T LH+A Y G  ++
Sbjct: 170 HGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAV 229

Query: 510 VKLLTSQGAELDAQQRNLRTPLHL-AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAA 568
           V  L   GA ++    N  TPLH  A        ++ L+ +GA  +   + G  PLH  A
Sbjct: 230 VNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTA 289

Query: 569 ARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWT 628
             G++   + L++ G  ++     G TPLH+AA  GH  +I+ L  S A+    G  +  
Sbjct: 290 VHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMF 349

Query: 629 PLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHAR 688
           PLHLAA +        LL  G + +  ++ G T LH A        +  L    A+ H +
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409

Query: 689 NKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS 735
           +K G TP H AA   +   ++ LV  GA ++  D    T L  A  S
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAAS 456



 Score =  169 bits (427), Expect = 1e-41
 Identities = 106/344 (30%), Positives = 171/344 (49%), Gaps = 1/344 (0%)

Query: 413 LLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNN 472
           +L+    D N +D +   PLH AA  GD     LL+  GA V+A++    TPLH A  + 
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 473 FENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLH 532
            E   ++L+   AD N  +   +TPLHVAA    V   +++    + ++   R  RT LH
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 533 LAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ 592
            A   G V  +  LL  GA  +A D+     LH AA  G   +  +L+ +GA +     +
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180

Query: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 652
           G+TPLH AA  G + ++  L      +  +     T LH+A  +G++AVV+ L+  GA+ 
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240

Query: 653 NAAEQSGWTPLHLAVQRSTFLSVINLLEHH-ANVHARNKVGWTPAHLAALKGNTAILKVL 711
           N    +G+TPLH A   +     + LL ++ A+V+ ++K G +P H+ A+ G     + L
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300

Query: 712 VEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLG 755
           ++ G ++D  D    TPL +A R   + +++ L       A  G
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCG 344



 Score =  157 bits (397), Expect = 3e-38
 Identities = 125/410 (30%), Positives = 185/410 (45%), Gaps = 31/410 (7%)

Query: 354 EELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCAL 413
           E  C  +   TPLH   + G +  V+ LL   V++D     G T L IA  + Q  +   
Sbjct: 173 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNE 232

Query: 414 LLAHGADANRVDEDGWAPLHFAAQNGDDGTA-RLLLDHGACVDAQEREGWTPLHLAAQNN 472
           L+ +GA+ N+ + +G+ PLHFAA +        LL+++GA V+ Q ++G +PLH+ A + 
Sbjct: 233 LIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHG 292

Query: 473 FENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLH 532
               ++ L+    + +  + +G TPLHVAA +GH  L+  L + GA+      +   PLH
Sbjct: 293 RFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLH 352

Query: 533 LAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ 592
           LA         + LL SG   D  D+ G   LH AAA G     K+L   GA        
Sbjct: 353 LAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKC 412

Query: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAAR---------------HG 637
           G TPLH AA   H   I  L  + AN+        T LH AA                + 
Sbjct: 413 GRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNS 472

Query: 638 EE-------------AVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHAN 684
           EE               +  LLQ  A+P+  ++ G+  +H A        +  LLE   +
Sbjct: 473 EELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNS 532

Query: 685 VHARNKVGWT--PAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732
               +  G T  P HLAA  G+   L+VL+++   LD++D    T L LA
Sbjct: 533 GFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLA 582



 Score =  153 bits (387), Expect = 5e-37
 Identities = 138/476 (28%), Positives = 211/476 (44%), Gaps = 72/476 (15%)

Query: 348 NLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQ 407
           NL    +E+ +Y N  T LH     G    V  L+ +  +V+    +G+TPL  AA    
Sbjct: 202 NLGVEIDEINVYGN--TALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTH 259

Query: 408 PDLCA-LLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLH 466
             LC  LL+ +GAD N   +DG +PLH  A +G    ++ L+ +G  +D  +++G TPLH
Sbjct: 260 GALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLH 319

Query: 467 LAAQNNFENVARLLVSRQADP----------------NLH-----------------EAE 493
           +AA+   E +   L +  AD                 N H                 +  
Sbjct: 320 VAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKF 379

Query: 494 GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553
           G+T LH AA  G+V  +KLL S GA+   + +  RTPLH A        I+ L+ +GA  
Sbjct: 380 GRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANV 439

Query: 554 DALDQSGYGPLHTAAA----RGKYLI------------------------CKMLLRYGAS 585
           +  D  G   LH AAA    R K ++                         + LL+  A+
Sbjct: 440 NETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDAN 499

Query: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMG---ALGAVNWTPLHLAARHGEEAVV 642
             +   +G+  +H AA  GH + + LL E   N G   +      +PLHLAA +G    +
Sbjct: 500 PSIRDKEGYNSIHYAAAYGHRQCLELLLE-RTNSGFEESDSGATKSPLHLAAYNGHHQAL 558

Query: 643 SALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGW-TPAHLAAL 701
             LLQ   D +  ++ G T L LA  +     V  L+   A++  ++ V   TP H + +
Sbjct: 559 EVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVI 618

Query: 702 KGNTAILKVLVEAGAQ---LDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATL 754
            G+T  L++L+E       +DV+D    TPL LA+       +S L  KE +V T+
Sbjct: 619 NGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTV 674



 Score =  146 bits (369), Expect = 6e-35
 Identities = 124/422 (29%), Positives = 181/422 (42%), Gaps = 34/422 (8%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           +PLH     G   + + L+ +  ++DC    G TPL +AA+     L   L   GAD  +
Sbjct: 283 SPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAK 342

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
                  PLH AA N      R LL  G  +D  ++ G T LH AA        +LL S 
Sbjct: 343 CGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSS 402

Query: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAV-------- 535
            AD +  +  G+TPLH AA   H   ++ L + GA ++      RT LH A         
Sbjct: 403 GADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNK 462

Query: 536 --------------------ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLI 575
                               E+     ++ LL++ A P   D+ GY  +H AAA G    
Sbjct: 463 TILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQC 522

Query: 576 CKMLLRYGASLELPTHQGWT--PLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633
            ++LL    S    +  G T  PLHLAAY GH + + +L +S  ++        T L LA
Sbjct: 523 LELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLA 582

Query: 634 ARHGEEAVVSALLQCGADPNAAEQ-SGWTPLHLAVQRSTFLSVINLLEHHAN---VHARN 689
           A  G    V AL+  GA     +  +  TPLH +V     L +  LLE   N   V  ++
Sbjct: 583 AFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642

Query: 690 KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEP 749
             G TP  LA   G+   + +L+E  A +D  D + CT L   + +  +  +  L  +E 
Sbjct: 643 AKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEV 702

Query: 750 SV 751
           S+
Sbjct: 703 SI 704



 Score =  142 bits (358), Expect = 1e-33
 Identities = 89/284 (31%), Positives = 141/284 (49%), Gaps = 3/284 (1%)

Query: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG 538
           +L+ +  D N  ++E +TPLHVAA+ G   +++LL   GA ++A+     TPLH AV   
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 539 KVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLH 598
              A+Q L+K  A  +A D++   PLH AAA       ++++   +S+ +    G T LH
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 599 LAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQS 658
            AA  GH+E+++LL    AN+ A    +   LH AA  G   VV+ L+  GA+    ++ 
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180

Query: 659 GWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQL 718
           G+TPLH A        V +LL     +   N  G T  H+A   G  A++  L++ GA +
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240

Query: 719 DVQDGVSCTPLQLALRSRKQGIMSFL---EGKEPSVATLGGSKP 759
           +  +    TPL  A  S    +   L    G + ++ +  G  P
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSP 284



 Score =  137 bits (344), Expect = 5e-32
 Identities = 111/388 (28%), Positives = 172/388 (44%), Gaps = 39/388 (10%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           T LH   A G+VE ++LL +   D   +   G TPL  AA +        L+  GA+ N 
Sbjct: 382 TCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNE 441

Query: 424 VDEDGWAPLHFAAQ-----------NGDDGTARL-----------------LLDHGACVD 455
            D+ G   LH+AA            N  D +  L                 LL + A   
Sbjct: 442 TDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPS 501

Query: 456 AQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG---KTPLHVAAYFGHVSLVKL 512
            +++EG+  +H AA         LL+ R  +    E++    K+PLH+AAY GH   +++
Sbjct: 502 IRDKEGYNSIHYAAAYGHRQCLELLLER-TNSGFEESDSGATKSPLHLAAYNGHHQALEV 560

Query: 513 LTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQ-SGYGPLHTAAARG 571
           L     +LD +    RT L LA  +G    ++ L+  GA     D  +   PLH +   G
Sbjct: 561 LLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVING 620

Query: 572 KYLICKMLLRYG---ASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWT 628
             L  ++LL       ++++   +G TPL LA   GH++ + LL E  AN+  +  +  T
Sbjct: 621 HTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCT 680

Query: 629 PLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR--STFLS-VINLLEHHANV 685
            LH     G E  V  LL+        +  G TPLH A  R  +T+LS ++ +     + 
Sbjct: 681 ALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740

Query: 686 HARNKVGWTPAHLAALKGNTAILKVLVE 713
             ++  G+TP H A   GN   ++VL+E
Sbjct: 741 CFKDNQGYTPLHWACYNGNENCIEVLLE 768



 Score =  133 bits (334), Expect = 7e-31
 Identities = 120/418 (28%), Positives = 182/418 (43%), Gaps = 39/418 (9%)

Query: 365 PLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRV 424
           PLH        +  R LL+   ++D     G T L  AA     +   LL + GAD ++ 
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409

Query: 425 DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA--------------Q 470
           D+ G  PLH+AA N        L+  GA V+  +  G T LH AA               
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAH 469

Query: 471 NNFENVAR--------------LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL--- 513
           +N E + R               L+   A+P++ + EG   +H AA +GH   ++LL   
Sbjct: 470 DNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLER 529

Query: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
           T+ G E ++     ++PLHLA   G  +A++ LL+S    D  D+ G   L  AA +G  
Sbjct: 530 TNSGFE-ESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHT 588

Query: 574 LICKMLLRYGASLELPTH-QGWTPLHLAAYKGHLEIIHLLAESHANMGALG---AVNWTP 629
              + L+  GAS+ +  +    TPLH +   GH   + LL E   N  A+    A   TP
Sbjct: 589 ECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648

Query: 630 LHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN 689
           L LA  +G    VS LL+  A+ +  +  G T LH  +       V  LLE   ++  ++
Sbjct: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708

Query: 690 KVGWTPAHLAALKGNTAILKVLVEAGAQLD---VQDGVSCTPLQLALRSRKQGIMSFL 744
             G TP H AA +G+   L  L++     +    +D    TPL  A  +  +  +  L
Sbjct: 709 SRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766



 Score =  128 bits (321), Expect = 2e-29
 Identities = 126/424 (29%), Positives = 182/424 (42%), Gaps = 26/424 (6%)

Query: 334 GNYLKRALQLSDRKNLVPRDEELCI---YENKVTP----------LHFLVAQGSVEQVRL 380
           GN    + +L   + L  ++  LC+    +N   P          +H+  A G  + + L
Sbjct: 466 GNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLEL 525

Query: 381 LLAHEVDVDCQTASGYT--PLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQN 438
           LL        ++ SG T  PL +AA +       +LL    D +  DE G   L  AA  
Sbjct: 526 LLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFK 585

Query: 439 GDDGTARLLLDHGACVDAQER-EGWTPLHLAAQNNFENVARLLVSRQADP---NLHEAEG 494
           G       L++ GA +  ++     TPLH +  N      RLL+    +P   ++ +A+G
Sbjct: 586 GHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKG 645

Query: 495 KTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPD 554
           +TPL +A  +GH+  V LL  + A +D       T LH  +  G    +Q LL+      
Sbjct: 646 QTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSIL 705

Query: 555 ALDQSGYGPLHTAAARGKYLICKMLLRYGASLE---LPTHQGWTPLHLAAYKGHLEIIHL 611
             D  G  PLH AAARG       LL+   S E      +QG+TPLH A Y G+   I +
Sbjct: 706 CKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEV 765

Query: 612 LAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQC--GADPNAAEQSGWTPLHLAVQR 669
           L E       +G   +TPLH A  +      S LL     +  +  +  G TPL  A   
Sbjct: 766 LLEQKCFRKFIGNP-FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFA 824

Query: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLV-EAGAQLDVQDGVSCTP 728
                +  LL H A V+A +  G T   +AA  G    + +LV  A A L V+D    TP
Sbjct: 825 DHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTP 884

Query: 729 LQLA 732
           L LA
Sbjct: 885 LHLA 888



 Score =  110 bits (274), Expect = 6e-24
 Identities = 103/351 (29%), Positives = 149/351 (42%), Gaps = 11/351 (3%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           +PLH     G  + + +LL   VD+D +   G T L +AA     +    L+  GA    
Sbjct: 544 SPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFV 603

Query: 424 VDE-DGWAPLHFAAQNGDDGTARLLL---DHGACVDAQEREGWTPLHLAAQNNFENVARL 479
            D      PLH +  NG     RLLL   D+   VD ++ +G TPL LA      +   L
Sbjct: 604 KDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSL 663

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L+ ++A+ +  +  G T LH     GH   V++L  Q   +  +    RTPLH A  RG 
Sbjct: 664 LLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGH 723

Query: 540 VRAIQHLLKSGAVPDAL---DQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTP 596
              +  LL+     +     D  GY PLH A   G     ++LL      +      +TP
Sbjct: 724 ATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKF-IGNPFTP 782

Query: 597 LHLAAYKGHLEIIHLL--AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654
           LH A    H     LL  A   + +        TPL  AA       +  LL+  A  NA
Sbjct: 783 LHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNA 842

Query: 655 AEQSGWTPLHLAVQRSTFLSVINLLEH-HANVHARNKVGWTPAHLAALKGN 704
            + SG T L +A +     +V  L+    A++  ++K   TP HLA  KG+
Sbjct: 843 VDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH 893



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 89/297 (29%), Positives = 131/297 (44%), Gaps = 16/297 (5%)

Query: 362 KVTPLHFLVAQGSVEQVRLLLA---HEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHG 418
           K TPLH  V  G    +RLLL    +   VD + A G TPL++A      D  +LLL   
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668

Query: 419 ADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNN----FE 474
           A+ + VD  G   LH     G +   ++LL+    +  ++  G TPLH AA         
Sbjct: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728

Query: 475 NVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLA 534
            + ++ +S + D    + +G TPLH A Y G+ + +++L  Q         N  TPLH A
Sbjct: 729 ELLQMALSEE-DCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC-FRKFIGNPFTPLHCA 786

Query: 535 VERGKVRAIQHLLKSGAVPDAL----DQSGYGPLHTAAARGKYLICKMLLRYGASLELPT 590
           +          LL  GA+  ++    D  G  PL  AA        ++LLR+ A +    
Sbjct: 787 IINDHGNCASLLL--GAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVD 844

Query: 591 HQGWTPLHLAAYKGHLEIIHLLAES-HANMGALGAVNWTPLHLAARHGEEAVVSALL 646
           + G T L +AA  G    + +L  S  A++        TPLHLA   G E     +L
Sbjct: 845 NSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 56/179 (31%), Positives = 85/179 (47%), Gaps = 7/179 (3%)

Query: 340 ALQLSDRKNLVPRDEELCIYENK-VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTP 398
           A  LS+   +   +E+ C  +N+  TPLH+    G+   + +LL  +        + +TP
Sbjct: 724 ATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKF-IGNPFTP 782

Query: 399 LLIAAQDQQPDLCALLLAHGADANRV---DEDGWAPLHFAAQNGDDGTARLLLDHGACVD 455
           L  A  +   + CA LL    D++ V   D+ G  PL  AA        +LLL H A V+
Sbjct: 783 LHCAIINDHGN-CASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVN 841

Query: 456 AQEREGWTPLHLAAQNNFENVARLLV-SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513
           A +  G T L +AA+N       +LV S QAD  + + +  TPLH+A   GH     L+
Sbjct: 842 AVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLI 900



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 45/133 (33%), Positives = 62/133 (46%), Gaps = 5/133 (3%)

Query: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVD---VDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
           N  TPLH  +         LLL   +D   V C+   G TPL  AA     +   LLL H
Sbjct: 778 NPFTPLHCAIINDHGNCASLLLG-AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH 836

Query: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHG-ACVDAQEREGWTPLHLAAQNNFENV 476
            A  N VD  G   L  AA+NG  G   +L++   A +  ++++  TPLHLA     E  
Sbjct: 837 SAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896

Query: 477 ARLLVSRQADPNL 489
           A L++ +  D +L
Sbjct: 897 ALLILDKIQDESL 909



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 38/120 (31%), Positives = 54/120 (45%), Gaps = 7/120 (5%)

Query: 331 SDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDC 390
           +D GN     L   D   +  RD++        TPL        VE ++LLL H   V+ 
Sbjct: 789 NDHGNCASLLLGAIDSSIVSCRDDK------GRTPLRAAAFADHVECLQLLLRHSAPVNA 842

Query: 391 QTASGYTPLLIAAQDQQPDLCALLLAHG-ADANRVDEDGWAPLHFAAQNGDDGTARLLLD 449
              SG T L++AA++ Q     +L+    AD    D+D   PLH A   G +  A L+LD
Sbjct: 843 VDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  177 bits (448), Expect = 4e-44
 Identities = 128/412 (31%), Positives = 196/412 (47%), Gaps = 39/412 (9%)

Query: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432
           GS++ V LL++   D++ + A G+TPL +AA+     +   L+  GA+ N  D+DGW  L
Sbjct: 556 GSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTAL 615

Query: 433 HFAAQNGD-----------------DGTARL----------------LLDHGACVDAQER 459
             AA  G                  D  +R                 LL HGA V+  + 
Sbjct: 616 RSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADN 675

Query: 460 EGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYF-----GHVSLVKLLT 514
           EG T L  AA      +   L+   A+ N  + +G+T L VAA       GH S+V LL 
Sbjct: 676 EGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLI 735

Query: 515 SQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL 574
            +GAE+D   ++  TPL +A   G V  +  LL+ GA  D  D +G  PL  AA+ G   
Sbjct: 736 DRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHAS 795

Query: 575 ICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAA 634
           +   LL +GA+++    +G T L +A+ +G++E++  L +   +        WTPLH+AA
Sbjct: 796 VVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAA 855

Query: 635 RHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWT 694
             G   +  AL++ GA  N  +  G  P  LA Q   +  V  LLE+ +N+  R   G  
Sbjct: 856 FEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRN 915

Query: 695 PAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQ-LALRSRKQGIMSFLE 745
              +AAL+G+  I+++L   GA ++ +D      L  LAL ++      FLE
Sbjct: 916 ALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLE 967



 Score =  174 bits (441), Expect = 3e-43
 Identities = 126/398 (31%), Positives = 179/398 (44%), Gaps = 38/398 (9%)

Query: 373  GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432
            G  E V  LL   V VDC  A   T L  AA     D+   LL HGA+ N+ D +G   L
Sbjct: 622  GHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTAL 681

Query: 433  HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA-----QNNFENVARLLVSRQADP 487
              AA  G       LLDHGA V+ ++ +G T L +AA          +V  LL+ R A+ 
Sbjct: 682  IAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEV 741

Query: 488  NLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL 547
            +  + +G TPL VAAY GHV +V LL   GA++D    N RTPL  A   G    +  LL
Sbjct: 742  DHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLL 801

Query: 548  KSGAVPDALDQ---------------------------------SGYGPLHTAAARGKYL 574
              GA  D++D                                  +G+ PLH AA  G  L
Sbjct: 802  FWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRL 861

Query: 575  ICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAA 634
            IC+ L+  GA      + G  P  LA+ +GH + + +L E+ +N+   G      L +AA
Sbjct: 862  ICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAA 921

Query: 635  RHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWT 694
              G   +V  L   GAD N  +  G   L++    +        LE+ ANV A +  G T
Sbjct: 922  LEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRT 981

Query: 695  PAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732
              H++  +G+  +++VL+   A ++  D    + LQ A
Sbjct: 982  ALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSA 1019



 Score =  166 bits (419), Expect = 1e-40
 Identities = 122/389 (31%), Positives = 183/389 (47%), Gaps = 2/389 (0%)

Query: 371  AQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWA 430
            ++G    V LL+    +VD     G TPLL+AA +   D+  LLL  GAD +  D +G  
Sbjct: 724  SKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRT 783

Query: 431  PLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH 490
            PL  AA  G       LL  GA VD+ + EG T L +A+      V R L+ R  D N  
Sbjct: 784  PLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHR 843

Query: 491  EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
            +  G TPLH+AA+ GH  + + L  QGA  +    + R P  LA + G    +Q LL++ 
Sbjct: 844  DDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENK 903

Query: 551  AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
            +  D     G   L  AA  G   I ++L  +GA +      G   L++ A +  L +  
Sbjct: 904  SNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAE 963

Query: 611  LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRS 670
               E+ AN+ A  A   T LH++   G   +V  L+   AD NAA+    + L  A  + 
Sbjct: 964  YFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQG 1023

Query: 671  TFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQ 730
                V  L+EH A V      G T   +AA +G+  +++VL+E GA  +  D    T ++
Sbjct: 1024 HVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMR 1083

Query: 731  LALRSRKQGIMSFLEGKEPSVATLGGSKP 759
            +A ++    I+  LE  +   ++L G  P
Sbjct: 1084 VAAKNGHSQIIKLLE--KYGASSLNGCSP 1110



 Score =  162 bits (409), Expect = 1e-39
 Identities = 119/398 (29%), Positives = 189/398 (47%), Gaps = 6/398 (1%)

Query: 363  VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
            +TPL     +G V+ V LLL    DVD    +G TPLL AA      +   LL  GA  +
Sbjct: 749  MTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVD 808

Query: 423  RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482
             +D +G   L  A+  G+    R LLD G   + ++  GWTPLH+AA      +   L+ 
Sbjct: 809  SIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIE 868

Query: 483  RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542
            + A  N  + +G+ P  +A+  GH   V++L    + +D +  + R  L +A   G    
Sbjct: 869  QGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDI 928

Query: 543  IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY 602
            ++ L   GA  +  D  G   L+  A   +  + +  L  GA++E    +G T LH++ +
Sbjct: 929  VELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCW 988

Query: 603  KGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662
            +GH+E++ +L   HA++ A      + L  AA  G   VV  L++ GA  +     G T 
Sbjct: 989  QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATA 1048

Query: 663  LHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722
            L +A Q      V  LLEH A+ +  ++ G T   +AA  G++ I+K+L + GA     +
Sbjct: 1049 LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA--SSLN 1106

Query: 723  GVSCTPL----QLALRSRKQGIMSFLEGKEPSVATLGG 756
            G S +P+    Q  L+S    + S       S +T GG
Sbjct: 1107 GCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGG 1144



 Score =  148 bits (373), Expect = 2e-35
 Identities = 100/337 (29%), Positives = 167/337 (49%), Gaps = 2/337 (0%)

Query: 361  NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
            N  TPL    + G    V  LL     VD   + G T L IA+     ++   LL  G D
Sbjct: 780  NGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLD 839

Query: 421  ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
             N  D+ GW PLH AA  G       L++ GA  +  + +G  P  LA+Q    +  ++L
Sbjct: 840  ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 899

Query: 481  VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
            +  +++ +    +G+  L VAA  GH  +V+LL S GA+++ +  + R  L++     ++
Sbjct: 900  LENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQL 959

Query: 541  RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
               ++ L++GA  +A D  G   LH +  +G   + ++L+ Y A +    ++  + L  A
Sbjct: 960  TMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSA 1019

Query: 601  AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660
            A++GH++++ LL E  A +        T L +AA+ G   VV  LL+ GADPN A+Q G 
Sbjct: 1020 AWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGR 1079

Query: 661  TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAH 697
            T + +A  ++    +I LLE +    + N    +P H
Sbjct: 1080 TAMRVAA-KNGHSQIIKLLEKY-GASSLNGCSPSPVH 1114



 Score =  147 bits (370), Expect = 5e-35
 Identities = 106/371 (28%), Positives = 182/371 (49%), Gaps = 3/371 (0%)

Query: 384  HEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGT 443
            HE DVD +TA     L + A      + +LL+  GA+ +  D+DG  PL  AA  G    
Sbjct: 705  HE-DVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV 763

Query: 444  ARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAY 503
              LLL+ GA VD  +  G TPL  AA     +V   L+   A  +  ++EG+T L +A+ 
Sbjct: 764  VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASA 823

Query: 504  FGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP 563
             G+V +V+ L  +G + + +     TPLH+A   G     + L++ GA  + +D  G  P
Sbjct: 824  QGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIP 883

Query: 564  LHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALG 623
               A+  G Y   ++LL   ++++   + G   L +AA +GH +I+ LL    A++    
Sbjct: 884  FILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKD 943

Query: 624  AVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHA 683
            A     L++ A   +  +    L+ GA+  A++  G T LH++  +     V  L+ +HA
Sbjct: 944  ADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA 1003

Query: 684  NVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSF 743
            +V+A +    +    AA +G+  ++++L+E GA +D       T L +A +     ++  
Sbjct: 1004 DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQV 1063

Query: 744  L--EGKEPSVA 752
            L   G +P+ A
Sbjct: 1064 LLEHGADPNHA 1074



 Score =  145 bits (365), Expect = 2e-34
 Identities = 113/395 (28%), Positives = 174/395 (44%), Gaps = 38/395 (9%)

Query: 376 EQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFA 435
           EQ  L L  +      +    T  ++    ++ D    LL +GA  N+ D +G   L  A
Sbjct: 493 EQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANA 552

Query: 436 AQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPN------- 488
           A +G      LL+  GA ++ ++  G TPL LAA+     V   L+   A+ N       
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612

Query: 489 --------------------------LHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDA 522
                                       +A+ +T L  AA+ GH  +V  L   GAE++ 
Sbjct: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672

Query: 523 QQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTA-----AARGKYLICK 577
                RT L  A   G    ++HLL  GA  +  D  G   L  A     A++G   +  
Sbjct: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732

Query: 578 MLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHG 637
           +L+  GA ++     G TPL +AAY+GH++++ LL E  A++        TPL  AA  G
Sbjct: 733 LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMG 792

Query: 638 EEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAH 697
             +VV+ LL  GA  ++ +  G T L +A  +     V  LL+   + + R+  GWTP H
Sbjct: 793 HASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLH 852

Query: 698 LAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732
           +AA +G+  I + L+E GA+ +  D     P  LA
Sbjct: 853 MAAFEGHRLICEALIEQGARTNEIDNDGRIPFILA 887



 Score =  133 bits (334), Expect = 7e-31
 Identities = 108/332 (32%), Positives = 160/332 (48%), Gaps = 7/332 (2%)

Query: 406 QQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPL 465
           ++ ++  LL+  GA  N  D+     +  A +  D  + R LLD+GA V+  +  G T L
Sbjct: 492 KEQEVLQLLVKAGAHVNSEDDRTSCIVRQALERED--SIRTLLDNGASVNQCDSNGRTLL 549

Query: 466 HLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR 525
             AA +   +V  LLVSR AD  + +A G TPL +AA  GH  +V  L   GA ++   +
Sbjct: 550 ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQ 609

Query: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS 585
           +  T L  A   G    +  LL +G   D  D      L  AA  G   I   LL++GA 
Sbjct: 610 DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAE 669

Query: 586 LELPTHQGWTPLHLAAYKGHLEII-HLLAE----SHANMGALGAVNWTPLHLAARHGEEA 640
           +    ++G T L  AAY GH EI+ HLL      +H ++    A++   L + A  G  +
Sbjct: 670 VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHAS 729

Query: 641 VVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAA 700
           VVS L+  GA+ +  ++ G TPL +A        V  LLE  A+V   +  G TP   AA
Sbjct: 730 VVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAA 789

Query: 701 LKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732
             G+ +++  L+  GA +D  D    T L +A
Sbjct: 790 SMGHASVVNTLLFWGAAVDSIDSEGRTVLSIA 821



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 43/155 (27%), Positives = 74/155 (47%), Gaps = 6/155 (3%)

Query: 595 TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARH---GEEAVVSALLQCGAD 651
           TPL    +  HL   +L  E+ A +      N TP+  +       E+ V+  L++ GA 
Sbjct: 448 TPLEAQEFALHLINSNLQLET-AELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAH 506

Query: 652 PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVL 711
            N+ +      +  A++R    S+  LL++ A+V+  +  G T    AA  G+  ++ +L
Sbjct: 507 VNSEDDRTSCIVRQALERED--SIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLL 564

Query: 712 VEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEG 746
           V  GA L+++D    TPL LA R     +++ L G
Sbjct: 565 VSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIG 599


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  166 bits (420), Expect = 8e-41
 Identities = 130/400 (32%), Positives = 188/400 (47%), Gaps = 48/400 (12%)

Query: 380 LLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNG 439
           LLL    +++ +T    TPL +A++    D+  +++ H A  N +D  G   LH AA  G
Sbjct: 385 LLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCG 444

Query: 440 DDGTARLLLDHGACVDAQEREGWTPLHLAAQN------------NFENVARLLVSRQADP 487
              T RLLL +G   +    +G+T L +  +N            N E   +LL + +A  
Sbjct: 445 HLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGD 504

Query: 488 -------------NLHEAEGK--TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLH 532
                        N  + EG+  TPLH AA +  VS+V+ L   GA++ A+ +    PLH
Sbjct: 505 VETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLH 564

Query: 533 LAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ 592
            A   G     + L+K GAV +  D   + PLH AAA+GKY ICK+LL++GA        
Sbjct: 565 NACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRD 624

Query: 593 GWTPLHL--------------------AAYKGHL-EIIHLLAESHANMGALGAVNWTPLH 631
           G TPL L                    AA KG L  +  L +  + N       + TPLH
Sbjct: 625 GNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLH 684

Query: 632 LAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKV 691
           LAA +    V   LLQ GAD NA ++ G  PLH A           L++++A V+A +K 
Sbjct: 685 LAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKW 744

Query: 692 GWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731
            +TP H AA KG T +  +L+  GA   +++    TPL L
Sbjct: 745 AFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784



 Score =  147 bits (371), Expect = 4e-35
 Identities = 129/466 (27%), Positives = 202/466 (43%), Gaps = 51/466 (10%)

Query: 319 EVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQV 378
           E  E  ++EL ++     ++R  +L   + +  RD        K TPLHF    G  + V
Sbjct: 19  EAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTA----GRKSTPLHFAAGFGRKDVV 74

Query: 379 RLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQN 438
             LL +  +V  +   G  PL  A      ++  LLL HGAD N  D   + PLH AA  
Sbjct: 75  EYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIK 134

Query: 439 GDDGTARLLLDHGACVDAQEREGWTPLHL---------------------AAQNNFENVA 477
           G      +LL HGA    +  +G T L L                     A   N E + 
Sbjct: 135 GKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMM 194

Query: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537
            LL     + +  +    TPLH+AA +  V +V+LL   GA++ A+ +    PLH A   
Sbjct: 195 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSY 254

Query: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597
           G     + L+K GA  +A+D   + PLH AA++ +  +C +LL YGA   L      + +
Sbjct: 255 GHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAI 314

Query: 598 HLA-----------AYKGHLEIIHLLAESHANM----GALGAVNW-------TPLHLAAR 635
            LA            +KGH  ++    E+         +L  VN+       T LH AA 
Sbjct: 315 DLAPTPQLKERLAYEFKGH-SLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAA 373

Query: 636 H---GEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVG 692
                 + +   LL+ GA+ N   +   TPLH+A +++    V  +++H A V+A + +G
Sbjct: 374 SPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLG 433

Query: 693 WTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQ 738
            T  H AA  G+    ++L+  G   ++      T LQ+   + +Q
Sbjct: 434 QTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQ 479



 Score =  142 bits (359), Expect = 9e-34
 Identities = 141/484 (29%), Positives = 206/484 (42%), Gaps = 75/484 (15%)

Query: 338 KRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGY- 396
           + AL L+D     P  + +   E K   L      G+ E++  LL   ++V+C  + G  
Sbjct: 158 RTALDLAD-----PSAKAVLTGEYKKDELLESARSGNEEKMMALLT-PLNVNCHASDGRK 211

Query: 397 -TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVD 455
            TPL +AA   +  +  LLL HGAD +  D+    PLH A   G      LL+ HGACV+
Sbjct: 212 STPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVN 271

Query: 456 AQEREGWTPLHLAAQNNFENVARLLVS--------------------------------- 482
           A +   +TPLH AA  N   V  LL+S                                 
Sbjct: 272 AMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFK 331

Query: 483 --------RQADPNL-------------HEAEGKTPLHVAA---YFGHVSLVKLLTSQGA 518
                   R+AD                H    +T LH AA   Y     + +LL  +GA
Sbjct: 332 GHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGA 391

Query: 519 ELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKM 578
            ++ + +   TPLH+A E+     ++ ++K  A  +ALD  G   LH AA  G    C++
Sbjct: 392 NINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRL 451

Query: 579 LLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGE 638
           LL YG    + + QG+T L +    G+  +  LL E   ++G   A     L  AA+ G+
Sbjct: 452 LLSYGCDPNIISLQGFTALQM----GNENVQQLLQEG-ISLGNSEADR--QLLEAAKAGD 504

Query: 639 EAVVSALLQC-GADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAH 697
              V  L      +    E    TPLH A   +    V  LL+H A+VHA++K G  P H
Sbjct: 505 VETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLH 564

Query: 698 LAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLG 755
            A   G+  + ++LV+ GA ++V D    TPL  A    K  I   L   G +P+     
Sbjct: 565 NACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRD 624

Query: 756 GSKP 759
           G+ P
Sbjct: 625 GNTP 628



 Score =  130 bits (327), Expect = 5e-30
 Identities = 98/305 (32%), Positives = 140/305 (45%), Gaps = 26/305 (8%)

Query: 373 GSVEQVRLLLAHEVDVDCQTASGY--TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWA 430
           G VE V+ L   +  V+C+   G   TPL  AA   +  +   LL HGAD +  D+ G  
Sbjct: 503 GDVETVKKLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLV 561

Query: 431 PLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH 490
           PLH A   G    A LL+ HGA V+  +   +TPLH AA      + +LL+   ADP   
Sbjct: 562 PLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKK 621

Query: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR---------------NLR------- 528
             +G TPL +    G   +  LL    A LDA ++               N R       
Sbjct: 622 NRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS 680

Query: 529 TPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLEL 588
           TPLHLA     +   ++LL+ GA  +A D+ G  PLH AA+ G   +  +L++Y A +  
Sbjct: 681 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNA 740

Query: 589 PTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQC 648
                +TPLH AA KG  ++  LL    A+         TPL L +     A+++A +  
Sbjct: 741 TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPP 800

Query: 649 GADPN 653
            A P+
Sbjct: 801 SALPS 805



 Score =  129 bits (323), Expect = 1e-29
 Identities = 94/302 (31%), Positives = 142/302 (47%), Gaps = 25/302 (8%)

Query: 321 NEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRL 380
           N +  ++L+++     ++   +L   +++  RD E      + TPLHF      V  V  
Sbjct: 489 NSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIE----GRQSTPLHFAAGYNRVSVVEY 544

Query: 381 LLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGD 440
           LL H  DV  +   G  PL  A      ++  LL+ HGA  N  D   + PLH AA  G 
Sbjct: 545 LLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGK 604

Query: 441 DGTARLLLDHGACVDAQEREGWTPLHLAA------QNNFENVARLL----------VSRQ 484
               +LLL HGA    + R+G TPL L        Q+     A LL          V + 
Sbjct: 605 YEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL 664

Query: 485 ADP---NLHEAEGK--TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           + P   N  + +G+  TPLH+AA + ++ + + L   GA+++AQ +    PLH A   G 
Sbjct: 665 SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGH 724

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
           V     L+K  A  +A D+  + PLH AA +G+  +C +LL +GA   L   +G TPL L
Sbjct: 725 VDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784

Query: 600 AA 601
            +
Sbjct: 785 VS 786



 Score =  119 bits (298), Expect = 1e-26
 Identities = 90/286 (31%), Positives = 126/286 (44%), Gaps = 21/286 (7%)

Query: 452 ACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVK 511
           A  +A E             + E V RL+   + +         TPLH AA FG   +V+
Sbjct: 16  AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVE 75

Query: 512 LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARG 571
            L   GA + A+      PLH A   G    +  LL+ GA P+A D   Y PLH AA +G
Sbjct: 76  YLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKG 135

Query: 572 KYLICKMLLRYGASLELPTHQGWTPLHLA--------------------AYKGHLE-IIH 610
           K  +C +LL++GA   +    G T L LA                    A  G+ E ++ 
Sbjct: 136 KIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMA 195

Query: 611 LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRS 670
           LL   + N  A      TPLHLAA +    +V  LLQ GAD +A ++    PLH A    
Sbjct: 196 LLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYG 255

Query: 671 TFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA 716
            +     L++H A V+A +   +TP H AA K    +  +L+  GA
Sbjct: 256 HYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301



 Score =  107 bits (267), Expect = 4e-23
 Identities = 79/229 (34%), Positives = 103/229 (44%), Gaps = 23/229 (10%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
           + PLH   + G  E   LL+ H   V+      +TPL  AA   + ++C LLL HGAD  
Sbjct: 560 LVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT 619

Query: 423 RVDEDGWAPLHFAAQNGDD------GTARLL----------------LDHGACVDAQERE 460
           + + DG  PL        D      G A LL                 D+  C D Q R 
Sbjct: 620 KKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRH 679

Query: 461 GWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL 520
             TPLHLAA  N   VA  L+   AD N  +  G  PLH AA +GHV +  LL    A +
Sbjct: 680 S-TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACV 738

Query: 521 DAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAA 569
           +A  +   TPLH A ++G+ +    LL  GA P   +Q G  PL   +A
Sbjct: 739 NATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 53/166 (31%), Positives = 77/166 (46%), Gaps = 4/166 (2%)

Query: 328 LMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVD 387
           L+D+     L R  +LS   N+  RD +        TPLH      ++E    LL H  D
Sbjct: 649 LLDAAKKGCLARVKKLSSPDNVNCRDTQ----GRHSTPLHLAAGYNNLEVAEYLLQHGAD 704

Query: 388 VDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLL 447
           V+ Q   G  PL  AA     D+ ALL+ + A  N  D+  + PLH AAQ G      LL
Sbjct: 705 VNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALL 764

Query: 448 LDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAE 493
           L HGA    + +EG TPL L + ++   +    +   A P+ ++ +
Sbjct: 765 LAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQ 810


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  161 bits (407), Expect = 2e-39
 Identities = 132/420 (31%), Positives = 186/420 (44%), Gaps = 51/420 (12%)

Query: 364 TPLHFLVAQGSVEQ---VRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
           T LH  VA    ++     LLL    +V+ +     TPL +AA+    D+  +L  HGA 
Sbjct: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583

Query: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTP---------------- 464
            N +D  G   LH AA  G   T RLLL +G+       +G+T                 
Sbjct: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSEST 643

Query: 465 -----------LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513
                      L  +   + E V +L  S+  +    E    TPLH AA +  VS+V+ L
Sbjct: 644 PIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYL 703

Query: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
              GA++ A+ +    PLH A   G     + L++ GA  +  D   + PLH AAA+GKY
Sbjct: 704 LHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKY 763

Query: 574 LICKMLLRYGASLELPTHQGWTPLHL--------------------AAYKGHL-EIIHLL 612
            ICK+LL++GA        G TPL L                    AA KG L  +  L 
Sbjct: 764 EICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLC 823

Query: 613 AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTF 672
              + N       N TPLHLAA +    V   LL+ GAD NA ++ G  PLH A      
Sbjct: 824 TPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHV 883

Query: 673 LSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732
                L++++  V+A +K  +TP H AA KG T +  +L+  GA   +++    TPL LA
Sbjct: 884 DIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943



 Score =  157 bits (396), Expect = 5e-38
 Identities = 145/483 (30%), Positives = 207/483 (42%), Gaps = 73/483 (15%)

Query: 338 KRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGY- 396
           K AL L+D     P  + +   E K   L      G+ E++  LL   ++V+C  + G  
Sbjct: 316 KSALDLAD-----PSAKAVLTGEYKKDELLEAARSGNEEKLMALLT-PLNVNCHASDGRK 369

Query: 397 -TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVD 455
            TPL +AA   +  +  LLL HGAD +  D+ G  PLH A   G      LLL HGACV+
Sbjct: 370 STPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVN 429

Query: 456 AQEREGWTPLHLAAQNNFENVARLLVSRQADPNL----------------------HEAE 493
           A +   +TPLH AA  N   V  LL+S  ADP L                      +E +
Sbjct: 430 AMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFK 489

Query: 494 G--------------------------------KTPLHVAAYFGHVS---LVKLLTSQGA 518
           G                                +T LH A    H     + +LL  +GA
Sbjct: 490 GHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGA 549

Query: 519 ELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKM 578
            ++ + ++  TPLH+A ER     ++ L K GA  +ALD  G   LH AA  G    C++
Sbjct: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609

Query: 579 LLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGE 638
           LL YG+   + + QG+T    AA  G+  +  +L+ES     +   V++  L  +     
Sbjct: 610 LLSYGSDPSIISLQGFT----AAQMGNEAVQQILSESTPIRTS--DVDYRLLEASKAGDL 663

Query: 639 EAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHL 698
           E V         +    E    TPLH A   +    V  LL H A+VHA++K G  P H 
Sbjct: 664 ETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHN 723

Query: 699 AALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGG 756
           A   G+  + ++LV  GA ++V D    TPL  A    K  I   L   G +P+     G
Sbjct: 724 ACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDG 783

Query: 757 SKP 759
           + P
Sbjct: 784 NTP 786



 Score =  146 bits (368), Expect = 8e-35
 Identities = 131/459 (28%), Positives = 201/459 (43%), Gaps = 46/459 (10%)

Query: 326 QELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHE 385
           +EL+++     + R  +L D  N+  +D    +   K +PLHF    G  + V  LL   
Sbjct: 184 RELLEACRNGDVSRVKRLVDAANVNAKD----MAGRKSSPLHFAAGFGRKDVVEHLLQMG 239

Query: 386 VDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTAR 445
            +V  +   G  PL  A      ++ +LLL  GAD N  D   + PLH AA  G      
Sbjct: 240 ANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCI 299

Query: 446 LLLDHGACVDAQEREGWTPLHL---------------------AAQNNFENVARLLVSRQ 484
           +LL HGA  + +  +G + L L                     A   N E +  LL    
Sbjct: 300 VLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLN 359

Query: 485 ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQ 544
            + +  +    TPLH+AA +  V +V+LL   GA++ A+ +    PLH A   G     +
Sbjct: 360 VNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTE 419

Query: 545 HLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKG 604
            LLK GA  +A+D   + PLH AA++ +  +C +LL +GA   L    G + + +A    
Sbjct: 420 LLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPE 479

Query: 605 HLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLH 664
             E +    + H+            L  AAR  + A V   L          QS  T LH
Sbjct: 480 LRERLTYEFKGHS------------LLQAAREADLAKVKKTLALEIINFKQPQSHETALH 527

Query: 665 LAV-----QRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
            AV     +R     +  LL   ANV+ +NK   TP H+AA + +  +++VL + GA+++
Sbjct: 528 CAVASLHPKRKQVTEL--LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN 585

Query: 720 VQDGVSCTPL-QLALRSRKQGIMSFLE-GKEPSVATLGG 756
             D +  T L + AL    Q     L  G +PS+ +L G
Sbjct: 586 ALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQG 624



 Score =  144 bits (364), Expect = 2e-34
 Identities = 135/462 (29%), Positives = 201/462 (43%), Gaps = 53/462 (11%)

Query: 351 PRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQP-- 408
           P   E   YE K   L     +  + +V+  LA E+    Q  S  T L  A     P  
Sbjct: 478 PELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKR 537

Query: 409 -DLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHL 467
             +  LLL  GA+ N  ++D   PLH AA+   +    +L  HGA ++A +  G T LH 
Sbjct: 538 KQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHR 597

Query: 468 AAQNNFENVARLLVSRQADPNLHEAEG-----------------KTPLHV---------A 501
           AA        RLL+S  +DP++   +G                  TP+           A
Sbjct: 598 AALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEA 657

Query: 502 AYFGHVSLVK-LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSG 560
           +  G +  VK L +SQ       +    TPLH A    +V  +++LL  GA   A D+ G
Sbjct: 658 SKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGG 717

Query: 561 YGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMG 620
             PLH A + G Y + ++L+R+GAS+ +     +TPLH AA KG  EI  LL +  A+  
Sbjct: 718 LVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPT 777

Query: 621 ALGAVNWTPLHLAAR---------HGEEAVVSALLQ-CGA---------DPNAAEQSGW- 660
                  TPL L             G+ A++ A  + C A         + N  +  G  
Sbjct: 778 KKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRN 837

Query: 661 -TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
            TPLHLA   +       LLEH A+V+A++K G  P H AA  G+  I  +L++    ++
Sbjct: 838 STPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN 897

Query: 720 VQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSKP 759
             D  + TPL  A +  +  + + L   G +P++    G  P
Sbjct: 898 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTP 939



 Score =  107 bits (267), Expect = 4e-23
 Identities = 78/229 (34%), Positives = 103/229 (44%), Gaps = 23/229 (10%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
           + PLH   + G  E   LL+ H   V+      +TPL  AA   + ++C LLL HGAD  
Sbjct: 718 LVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPT 777

Query: 423 RVDEDGWAPLHFAAQNGDD------GTARLL----------------LDHGACVDAQERE 460
           + + DG  PL    +   D      G A LL                 ++  C D Q R 
Sbjct: 778 KKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRN 837

Query: 461 GWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL 520
             TPLHLAA  N   VA  L+   AD N  +  G  PLH AA +GHV +  LL      +
Sbjct: 838 S-TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCV 896

Query: 521 DAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAA 569
           +A  +   TPLH A ++G+ +    LL  GA P   +Q G  PL  A A
Sbjct: 897 NATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 63/192 (32%), Positives = 87/192 (45%), Gaps = 19/192 (9%)

Query: 300 ESKALARKVSCKLSLRQ---PGEVNEDISQELM-----DSDSGNYLKRALQLSD--RKNL 349
           E+ A  +   CKL L+    P + N D +  L      D+D  + L+    L D  +K  
Sbjct: 756 EAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGC 815

Query: 350 VPRDEELCIYEN---------KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLL 400
           + R ++LC  EN           TPLH      ++E    LL H  DV+ Q   G  PL 
Sbjct: 816 LARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLH 875

Query: 401 IAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE 460
            AA     D+ ALL+ +    N  D+  + PLH AAQ G      LLL HGA    + +E
Sbjct: 876 NAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQE 935

Query: 461 GWTPLHLAAQNN 472
           G TPL LA  ++
Sbjct: 936 GQTPLDLATADD 947


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  160 bits (406), Expect = 3e-39
 Identities = 132/382 (34%), Positives = 177/382 (46%), Gaps = 6/382 (1%)

Query: 373 GSVEQVRLLLAHEVDVDCQTASG-YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431
           G  E  ++LLA   +V+ +   G  TPL+ AA      +  LLLAH AD N     G   
Sbjct: 278 GYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTA 337

Query: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491
           L +A   G     ++LL+ GA ++     G TPL  A       VARLL+   A  N H 
Sbjct: 338 LTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS 397

Query: 492 AEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
            E K + L +A Y GH+ +V+ L   GA+ + +   + T L  A   G V   + LL SG
Sbjct: 398 NEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 457

Query: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
           A  +    S   PL  AA  G   +  +L+  GASLE    +G+TPL  AA +GH E++ 
Sbjct: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517

Query: 611 LLAESHANMGA-LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669
           LL    AN+ A       T L LA   G   V   L++ GAD    E    TPL  A Q 
Sbjct: 518 LLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD---IELGCSTPLMEAAQE 574

Query: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729
                V  LL   ANVHA    G T    A   G+T +  VL++AGA L+ +     TPL
Sbjct: 575 GHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 634

Query: 730 QLALRSRKQGIMSFLEGKEPSV 751
             A R+     + FL  K  +V
Sbjct: 635 MKAARAGHVCTVQFLISKGANV 656



 Score =  151 bits (382), Expect = 2e-36
 Identities = 120/365 (32%), Positives = 172/365 (47%), Gaps = 38/365 (10%)

Query: 386  VDVDCQTASGY-TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTA 444
            +D+D QT S + T L +A      +L   LL  GA     D+ G+ PL  AA  G  G  
Sbjct: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 1132

Query: 445  RLLLDHGACVDAQ-EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAY 503
             +LLD+GA ++AQ ER   TPL LA     + V  LL++R A+         TPL +AA 
Sbjct: 1133 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 1192

Query: 504  FGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP 563
             G+V+++K+L + GAE+     N RT   L                          G  P
Sbjct: 1193 GGYVNIIKILLNAGAEI-----NSRTGSKL--------------------------GISP 1221

Query: 564  LHTAAARGKYLICKMLLRYGASL--ELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGA 621
            L  AA  G     K+LL  G+ +  ++ T++  T L LA ++G  E++ LL +  AN+  
Sbjct: 1222 LMLAAMNGHTAAVKLLLDMGSDINAQIETNRN-TALTLACFQGRTEVVSLLLDRKANVEH 1280

Query: 622  LGAVNWTPLHLAARHGEEAVVSALLQCGADPNA--AEQSGWTPLHLAVQRSTFLSVINLL 679
                  TPL  AA  G   V   LL  GAD NA     S  T L +A  +  +     L+
Sbjct: 1281 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1340

Query: 680  EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQG 739
               A++  RNK G TP  LAA  G+  ++++LV+AGA +D  D    TPL  A R     
Sbjct: 1341 GRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVK 1400

Query: 740  IMSFL 744
            ++ +L
Sbjct: 1401 VVRYL 1405



 Score =  145 bits (367), Expect = 1e-34
 Identities = 119/387 (30%), Positives = 172/387 (44%), Gaps = 33/387 (8%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
           +TPL      G V+ V+LLLAH+ DV+ Q+++G T L  A      D+  +LL  GA   
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361

Query: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENVARLLV 481
             +E+G  PL  A   G    ARLLL++GA ++    E   + L LA       + R L+
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421

Query: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
              AD      E  T L  A   GHV + +LL   GA+++    +  +PL LA   G V 
Sbjct: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481

Query: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW------- 594
               L++ GA  + ++  GY PL  AA  G   +  +LL  GA++   T +         
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541

Query: 595 ------------------------TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
                                   TPL  AA +GHLE++  L  + AN+ A  A   T L
Sbjct: 542 CCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601

Query: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN- 689
             A  +G   V   LLQ GAD     + G TPL  A +     +V  L+   ANV+    
Sbjct: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661

Query: 690 KVGWTPAHLAALKGNTAILKVLVEAGA 716
               T   LA   G+ A++++L+  GA
Sbjct: 662 NNDHTVLSLACAGGHLAVVELLLAHGA 688



 Score =  135 bits (340), Expect = 1e-31
 Identities = 108/330 (32%), Positives = 157/330 (47%), Gaps = 7/330 (2%)

Query: 361  NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
            N  T L    A G  E V+ LL     ++ +   G+TPL++AA      +  +LL +GAD
Sbjct: 1082 NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 1141

Query: 421  ANRVDE-DGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
                 E     PL  A   G      LLL  GA  + +    +TPL LAA   + N+ ++
Sbjct: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1201

Query: 480  LVSRQADPNLHEAE--GKTPLHVAAYFGHVSLVKLLTSQGAELDAQ-QRNLRTPLHLAVE 536
            L++  A+ N       G +PL +AA  GH + VKLL   G++++AQ + N  T L LA  
Sbjct: 1202 LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACF 1261

Query: 537  RGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP--THQGW 594
            +G+   +  LL   A  +   ++G  PL  AA+ G   + ++LL  GA +  P       
Sbjct: 1262 QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1321

Query: 595  TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654
            T L +AA KGH +   LL    A++        TPL LAA  G   VV  L+Q GAD +A
Sbjct: 1322 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1381

Query: 655  AEQSGWTPLHLAVQRSTFLSVINLLEHHAN 684
            A+    TPL +A  R   + V+  L    N
Sbjct: 1382 ADNRKITPL-MAAFRKGHVKVVRYLVKEVN 1410



 Score =  128 bits (321), Expect = 2e-29
 Identities = 114/368 (30%), Positives = 169/368 (45%), Gaps = 11/368 (2%)

Query: 321 NEDISQELMDSDSGNYLKRA-LQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVR 379
           NE+    LM++ S  +++ A L L +   +     E      K + L     +G +E VR
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF-----KESALTLACYKGHLEMVR 418

Query: 380 LLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNG 439
            LL    D + +T   +T L+ A  D   ++  LLL  GA  N   +   +PL  AA  G
Sbjct: 419 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 478

Query: 440 DDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH-EAEGKTPL 498
               A LL++ GA ++    EG+TPL  AA+   E +  LL+ + A+ N   E   +T L
Sbjct: 479 HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538

Query: 499 HVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQ 558
            +A   G + +   L   GA+++       TPL  A + G +  +++LL +GA   A   
Sbjct: 539 TLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTA 595

Query: 559 SGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHAN 618
           +G   L  A   G   +  +LL+ GA LE  +  G TPL  AA  GH+  +  L    AN
Sbjct: 596 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGAN 655

Query: 619 MGALGAVN-WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN 677
           +    A N  T L LA   G  AVV  LL  GADP    + G T L  A +      V  
Sbjct: 656 VNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCY 715

Query: 678 LLEHHANV 685
           LL++  N+
Sbjct: 716 LLDYPNNL 723



 Score =  120 bits (301), Expect = 5e-27
 Identities = 92/289 (31%), Positives = 141/289 (48%), Gaps = 2/289 (0%)

Query: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494
           A   GD    R LL  G  V+    EG + L LA    +  +A++L++  A+      +G
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300

Query: 495 K-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553
             TPL  AA  GHV +VKLL +  A+++AQ     T L  A   G V  ++ LL+SGA  
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360

Query: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ-GWTPLHLAAYKGHLEIIHLL 612
           +  +++G+ PL  A + G   + ++LL  GA +   +++   + L LA YKGHLE++  L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420

Query: 613 AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTF 672
            E+ A+         T L  A   G   V   LL  GA  N    S  +PL LA      
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480

Query: 673 LSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
                L+E  A++   N  G+TP   AA +G+  ++ +L+  GA ++ Q
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 57/173 (32%), Positives = 82/173 (47%), Gaps = 2/173 (1%)

Query: 358  IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
            I  N+ T L     QG  E V LLL  + +V+ +  +G TPL+ AA     ++  +LL  
Sbjct: 1248 IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1307

Query: 418  GADANR--VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN 475
            GAD N   V       L  AA  G      LL+  GA +D + ++G TPL LAA     +
Sbjct: 1308 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD 1367

Query: 476  VARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLR 528
            V +LLV   AD +  +    TPL  A   GHV +V+ L  +  +  +    +R
Sbjct: 1368 VVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMR 1420



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 41/134 (30%), Positives = 64/134 (47%), Gaps = 1/134 (0%)

Query: 628  TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687
            T L LA   G E +V  LL+ GA     ++ G+TPL LA        V  LL++ A++ A
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 688  RN-KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEG 746
            ++ +   TP  LA   G   ++++L+  GA  + ++    TPL LA       I+  L  
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204

Query: 747  KEPSVATLGGSKPG 760
                + +  GSK G
Sbjct: 1205 AGAEINSRTGSKLG 1218


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
           sapiens]
          Length = 2352

 Score =  160 bits (406), Expect = 3e-39
 Identities = 132/382 (34%), Positives = 177/382 (46%), Gaps = 6/382 (1%)

Query: 373 GSVEQVRLLLAHEVDVDCQTASG-YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431
           G  E  ++LLA   +V+ +   G  TPL+ AA      +  LLLAH AD N     G   
Sbjct: 278 GYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTA 337

Query: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491
           L +A   G     ++LL+ GA ++     G TPL  A       VARLL+   A  N H 
Sbjct: 338 LTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS 397

Query: 492 AEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
            E K + L +A Y GH+ +V+ L   GA+ + +   + T L  A   G V   + LL SG
Sbjct: 398 NEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 457

Query: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
           A  +    S   PL  AA  G   +  +L+  GASLE    +G+TPL  AA +GH E++ 
Sbjct: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517

Query: 611 LLAESHANMGA-LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669
           LL    AN+ A       T L LA   G   V   L++ GAD    E    TPL  A Q 
Sbjct: 518 LLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD---IELGCSTPLMEAAQE 574

Query: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729
                V  LL   ANVHA    G T    A   G+T +  VL++AGA L+ +     TPL
Sbjct: 575 GHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 634

Query: 730 QLALRSRKQGIMSFLEGKEPSV 751
             A R+     + FL  K  +V
Sbjct: 635 MKAARAGHVCTVQFLISKGANV 656



 Score =  151 bits (382), Expect = 2e-36
 Identities = 120/365 (32%), Positives = 172/365 (47%), Gaps = 38/365 (10%)

Query: 386  VDVDCQTASGY-TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTA 444
            +D+D QT S + T L +A      +L   LL  GA     D+ G+ PL  AA  G  G  
Sbjct: 822  IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 881

Query: 445  RLLLDHGACVDAQ-EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAY 503
             +LLD+GA ++AQ ER   TPL LA     + V  LL++R A+         TPL +AA 
Sbjct: 882  EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 941

Query: 504  FGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP 563
             G+V+++K+L + GAE+     N RT   L                          G  P
Sbjct: 942  GGYVNIIKILLNAGAEI-----NSRTGSKL--------------------------GISP 970

Query: 564  LHTAAARGKYLICKMLLRYGASL--ELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGA 621
            L  AA  G     K+LL  G+ +  ++ T++  T L LA ++G  E++ LL +  AN+  
Sbjct: 971  LMLAAMNGHTAAVKLLLDMGSDINAQIETNRN-TALTLACFQGRTEVVSLLLDRKANVEH 1029

Query: 622  LGAVNWTPLHLAARHGEEAVVSALLQCGADPNA--AEQSGWTPLHLAVQRSTFLSVINLL 679
                  TPL  AA  G   V   LL  GAD NA     S  T L +A  +  +     L+
Sbjct: 1030 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1089

Query: 680  EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQG 739
               A++  RNK G TP  LAA  G+  ++++LV+AGA +D  D    TPL  A R     
Sbjct: 1090 GRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVK 1149

Query: 740  IMSFL 744
            ++ +L
Sbjct: 1150 VVRYL 1154



 Score =  145 bits (367), Expect = 1e-34
 Identities = 119/387 (30%), Positives = 172/387 (44%), Gaps = 33/387 (8%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
           +TPL      G V+ V+LLLAH+ DV+ Q+++G T L  A      D+  +LL  GA   
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361

Query: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENVARLLV 481
             +E+G  PL  A   G    ARLLL++GA ++    E   + L LA       + R L+
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421

Query: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
              AD      E  T L  A   GHV + +LL   GA+++    +  +PL LA   G V 
Sbjct: 422 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 481

Query: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW------- 594
               L++ GA  + ++  GY PL  AA  G   +  +LL  GA++   T +         
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541

Query: 595 ------------------------TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
                                   TPL  AA +GHLE++  L  + AN+ A  A   T L
Sbjct: 542 CCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601

Query: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN- 689
             A  +G   V   LLQ GAD     + G TPL  A +     +V  L+   ANV+    
Sbjct: 602 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTA 661

Query: 690 KVGWTPAHLAALKGNTAILKVLVEAGA 716
               T   LA   G+ A++++L+  GA
Sbjct: 662 NNDHTVLSLACAGGHLAVVELLLAHGA 688



 Score =  135 bits (340), Expect = 1e-31
 Identities = 108/330 (32%), Positives = 157/330 (47%), Gaps = 7/330 (2%)

Query: 361  NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
            N  T L    A G  E V+ LL     ++ +   G+TPL++AA      +  +LL +GAD
Sbjct: 831  NHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD 890

Query: 421  ANRVDE-DGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
                 E     PL  A   G      LLL  GA  + +    +TPL LAA   + N+ ++
Sbjct: 891  IEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 950

Query: 480  LVSRQADPNLHEAE--GKTPLHVAAYFGHVSLVKLLTSQGAELDAQ-QRNLRTPLHLAVE 536
            L++  A+ N       G +PL +AA  GH + VKLL   G++++AQ + N  T L LA  
Sbjct: 951  LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACF 1010

Query: 537  RGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP--THQGW 594
            +G+   +  LL   A  +   ++G  PL  AA+ G   + ++LL  GA +  P       
Sbjct: 1011 QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1070

Query: 595  TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654
            T L +AA KGH +   LL    A++        TPL LAA  G   VV  L+Q GAD +A
Sbjct: 1071 TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1130

Query: 655  AEQSGWTPLHLAVQRSTFLSVINLLEHHAN 684
            A+    TPL +A  R   + V+  L    N
Sbjct: 1131 ADNRKITPL-MAAFRKGHVKVVRYLVKEVN 1159



 Score =  128 bits (321), Expect = 2e-29
 Identities = 114/368 (30%), Positives = 169/368 (45%), Gaps = 11/368 (2%)

Query: 321 NEDISQELMDSDSGNYLKRA-LQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVR 379
           NE+    LM++ S  +++ A L L +   +     E      K + L     +G +E VR
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF-----KESALTLACYKGHLEMVR 418

Query: 380 LLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNG 439
            LL    D + +T   +T L+ A  D   ++  LLL  GA  N   +   +PL  AA  G
Sbjct: 419 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 478

Query: 440 DDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH-EAEGKTPL 498
               A LL++ GA ++    EG+TPL  AA+   E +  LL+ + A+ N   E   +T L
Sbjct: 479 HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETAL 538

Query: 499 HVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQ 558
            +A   G + +   L   GA+++       TPL  A + G +  +++LL +GA   A   
Sbjct: 539 TLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTA 595

Query: 559 SGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHAN 618
           +G   L  A   G   +  +LL+ GA LE  +  G TPL  AA  GH+  +  L    AN
Sbjct: 596 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGAN 655

Query: 619 MGALGAVN-WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN 677
           +    A N  T L LA   G  AVV  LL  GADP    + G T L  A +      V  
Sbjct: 656 VNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCY 715

Query: 678 LLEHHANV 685
           LL++  N+
Sbjct: 716 LLDYPNNL 723



 Score =  120 bits (301), Expect = 5e-27
 Identities = 92/289 (31%), Positives = 141/289 (48%), Gaps = 2/289 (0%)

Query: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494
           A   GD    R LL  G  V+    EG + L LA    +  +A++L++  A+      +G
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300

Query: 495 K-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553
             TPL  AA  GHV +VKLL +  A+++AQ     T L  A   G V  ++ LL+SGA  
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360

Query: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ-GWTPLHLAAYKGHLEIIHLL 612
           +  +++G+ PL  A + G   + ++LL  GA +   +++   + L LA YKGHLE++  L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420

Query: 613 AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTF 672
            E+ A+         T L  A   G   V   LL  GA  N    S  +PL LA      
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480

Query: 673 LSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
                L+E  A++   N  G+TP   AA +G+  ++ +L+  GA ++ Q
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529



 Score =  102 bits (253), Expect = 2e-21
 Identities = 117/412 (28%), Positives = 174/412 (42%), Gaps = 25/412 (6%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           TPL     +G +E V+ LLA   +V   TA+G T L  A ++   D+  +LL  GAD   
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVD-AQEREGWTPLHLAAQNNFENVARLLVS 482
             E G  PL  AA+ G   T + L+  GA V+        T L LA       V  LL++
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685

Query: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL------DAQQRNLRTPLH--LA 534
             ADP     +G T L  AA  GH S+V  L      L      D  Q  L  P H    
Sbjct: 686 HGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQ--LTPPSHDLNR 743

Query: 535 VERGKVRAIQHLLKSGAVPDA--LDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ 592
             R  V+A+  ++     PD    + +   P+   A  G+         +  +  +   Q
Sbjct: 744 APRVPVQALPMVVPPQE-PDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQ 802

Query: 593 GWTPLHLAAYKGHLEI---IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCG 649
             TP  + +    L I   I + A++ +N         T L LA   G E +V  LL+ G
Sbjct: 803 TPTPSPIISPSAMLPIYPAIDIDAQTESNHD-------TALTLACAGGHEELVQTLLERG 855

Query: 650 ADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN-KVGWTPAHLAALKGNTAIL 708
           A     ++ G+TPL LA        V  LL++ A++ A++ +   TP  LA   G   ++
Sbjct: 856 ASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVV 915

Query: 709 KVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGSKPG 760
           ++L+  GA  + ++    TPL LA       I+  L      + +  GSK G
Sbjct: 916 ELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 967



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 57/173 (32%), Positives = 82/173 (47%), Gaps = 2/173 (1%)

Query: 358  IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
            I  N+ T L     QG  E V LLL  + +V+ +  +G TPL+ AA     ++  +LL  
Sbjct: 997  IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1056

Query: 418  GADANR--VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN 475
            GAD N   V       L  AA  G      LL+  GA +D + ++G TPL LAA     +
Sbjct: 1057 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLD 1116

Query: 476  VARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLR 528
            V +LLV   AD +  +    TPL  A   GHV +V+ L  +  +  +    +R
Sbjct: 1117 VVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMR 1169


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  158 bits (400), Expect = 2e-38
 Identities = 130/382 (34%), Positives = 178/382 (46%), Gaps = 6/382 (1%)

Query: 373 GSVEQVRLLLAHEVDVDCQTASG-YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431
           G  E  ++LLA   +V+ +   G  TPL+ A+     D+  LLL H AD N     G   
Sbjct: 249 GYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA 308

Query: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491
           L +A   G     ++LL+ GA ++     G TPL  AA      VAR+L+   A  N H 
Sbjct: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368

Query: 492 AEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
            E K + L +A Y GH+ +V+ L   GA+ + +   + T L  A   G V   + LL SG
Sbjct: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428

Query: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
           A  +    S   PL  AA  G   +  +L+  GA+LE    +G+TPL  AA +GH E++ 
Sbjct: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488

Query: 611 LLAESHANMGA-LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669
           LL    AN+ A       T L LA   G   V   L++ GAD    E    TPL  A Q 
Sbjct: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLMEASQE 545

Query: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729
                V  LL   ANVHA    G T    A   G+T +  VL++AGA L+ +     TPL
Sbjct: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 605

Query: 730 QLALRSRKQGIMSFLEGKEPSV 751
             A R+     + FL  K  +V
Sbjct: 606 MKAARAGHLCTVQFLISKGANV 627



 Score =  151 bits (382), Expect = 2e-36
 Identities = 126/415 (30%), Positives = 186/415 (44%), Gaps = 33/415 (7%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
           +TPL    + G ++ V+LLL H+ DV+ Q+A+G T L  A      D+  +LL  GA+  
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332

Query: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENVARLLV 481
             +E+G  PL  AA  G    AR+LLDHGA ++    E   + L LA      ++ R L+
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
              AD      E  T L  A   GHV + +LL   GA+++    +  +PL LA   G V 
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW------- 594
               L++ GA  + ++  GY PL  AA  G   +  +LL  GA++   T +         
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 595 ------------------------TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
                                   TPL  A+ +GHLE++  L  S AN+ A  A   T L
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572

Query: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH-ARN 689
             A  +G   V   LLQ GAD     + G TPL  A +     +V  L+   ANV+ A  
Sbjct: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632

Query: 690 KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
               T   LA   G+ A++++L+  GA    +     T L  A +     ++S+L
Sbjct: 633 NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687



 Score =  144 bits (364), Expect = 2e-34
 Identities = 116/365 (31%), Positives = 171/365 (46%), Gaps = 38/365 (10%)

Query: 386  VDVDCQTASGY-TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTA 444
            VD+D  T S + T L +A      +L ++L+A  A     D+ G+ PL  AA  G  G  
Sbjct: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104

Query: 445  RLLLDHGACVDAQ-EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAY 503
             +LLD G  ++AQ ER   TPL LA     + V  LL++R A+         TPL +AA 
Sbjct: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164

Query: 504  FGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP 563
             G+V+++K+L + GAE+     N RT   L +                           P
Sbjct: 1165 GGYVNIIKILLNAGAEI-----NSRTGSKLGI--------------------------SP 1193

Query: 564  LHTAAARGKYLICKMLLRYGASL--ELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGA 621
            L  AA  G     K+LL  G+ +  ++ T++  T L LA ++G  E++ LL +  AN+  
Sbjct: 1194 LMLAAMNGHVPAVKLLLDMGSDINAQIETNRN-TALTLACFQGRAEVVSLLLDRKANVEH 1252

Query: 622  LGAVNWTPLHLAARHGEEAVVSALLQCGADPNA--AEQSGWTPLHLAVQRSTFLSVINLL 679
                  TPL  AA  G   V   LL  GAD NA     S  T L +A  +  +     L+
Sbjct: 1253 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1312

Query: 680  EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQG 739
               A++  RNK G TP  LA+  G+  ++++LV+AGA +D  D    TPL  A R     
Sbjct: 1313 HRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVK 1372

Query: 740  IMSFL 744
            ++ +L
Sbjct: 1373 VVQYL 1377



 Score =  134 bits (336), Expect = 4e-31
 Identities = 106/330 (32%), Positives = 157/330 (47%), Gaps = 7/330 (2%)

Query: 361  NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
            N  T L    A G  E V +L+A +  ++ +   G+TPL++AA      +  +LL  G D
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113

Query: 421  ANRVDE-DGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
                 E     PL  A   G      LLL  GA  + +    +TPL LAA   + N+ ++
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173

Query: 480  LVSRQADPNLHEAE--GKTPLHVAAYFGHVSLVKLLTSQGAELDAQ-QRNLRTPLHLAVE 536
            L++  A+ N       G +PL +AA  GHV  VKLL   G++++AQ + N  T L LA  
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233

Query: 537  RGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP--THQGW 594
            +G+   +  LL   A  +   ++G  PL  AA+ G   + ++LL  GA +  P       
Sbjct: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293

Query: 595  TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654
            T L +AA KGH +   LL    A++        TPL LA+  G   VV  L+Q GAD +A
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353

Query: 655  AEQSGWTPLHLAVQRSTFLSVINLLEHHAN 684
            A+    TPL ++  R   + V+  L    N
Sbjct: 1354 ADNRKITPL-MSAFRKGHVKVVQYLVKEVN 1382



 Score =  127 bits (318), Expect = 5e-29
 Identities = 115/367 (31%), Positives = 168/367 (45%), Gaps = 9/367 (2%)

Query: 321 NEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRL 380
           NE+    LM++ S  +++ A  L D    +         E K + L     +G ++ VR 
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN----EFKESALTLACYKGHLDMVRF 390

Query: 381 LLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGD 440
           LL    D + +T   +T L+ A  D   ++  LLL  GA  N   +   +PL  AA  G 
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450

Query: 441 DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH-EAEGKTPLH 499
              A LL++ GA ++    EG+TPL  AA+   E +  LL+++ A+ N   E   +T L 
Sbjct: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 510

Query: 500 VAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559
           +A   G   +   L   GA+++       TPL  A + G +  +++LL SGA   A   +
Sbjct: 511 LACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTAT 567

Query: 560 GYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANM 619
           G   L  A   G   +  +LL+ GA LE  +  G TPL  AA  GHL  +  L    AN+
Sbjct: 568 GDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANV 627

Query: 620 GALGAVN-WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINL 678
               A N  T + LA   G  AVV  LL  GADP    + G T L  A +      V  L
Sbjct: 628 NRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687

Query: 679 LEHHANV 685
           L++  NV
Sbjct: 688 LDYPNNV 694



 Score =  117 bits (293), Expect = 4e-26
 Identities = 89/289 (30%), Positives = 142/289 (49%), Gaps = 2/289 (0%)

Query: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494
           A  +GD    R LLD G  V+    EG + L LA    +  +A++L++  A+      +G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271

Query: 495 K-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553
             TPL  A+  G++ +VKLL    A++++Q     T L  A   G V  ++ LL  GA  
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331

Query: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ-GWTPLHLAAYKGHLEIIHLL 612
           +  +++G+ PL  AA+ G   + ++LL +GA +   +++   + L LA YKGHL+++  L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391

Query: 613 AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTF 672
            E+ A+         T L  A   G   V   LL  GA  N    S  +PL LA      
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451

Query: 673 LSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
                L+E  AN+   N  G+TP   AA +G+  ++ +L+  GA ++ Q
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 55/161 (34%), Positives = 78/161 (48%), Gaps = 2/161 (1%)

Query: 358  IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
            I  N+ T L     QG  E V LLL  + +V+ +  +G TPL+ AA     ++  +LL  
Sbjct: 1220 IETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1279

Query: 418  GADANR--VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN 475
            GAD N   V       L  AA  G      LL+  GA +D + ++G TPL LA+     +
Sbjct: 1280 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFD 1339

Query: 476  VARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQ 516
            V +LLV   AD +  +    TPL  A   GHV +V+ L  +
Sbjct: 1340 VVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 39/134 (29%), Positives = 60/134 (44%), Gaps = 1/134 (0%)

Query: 628  TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687
            T L LA   G E +VS L+   A     ++ G+TPL LA        V  LL+   ++ A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 688  RN-KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEG 746
            ++ +   TP  LA   G   ++ +L+  GA  + ++    TPL LA       I+  L  
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176

Query: 747  KEPSVATLGGSKPG 760
                + +  GSK G
Sbjct: 1177 AGAEINSRTGSKLG 1190


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  158 bits (400), Expect = 2e-38
 Identities = 130/382 (34%), Positives = 178/382 (46%), Gaps = 6/382 (1%)

Query: 373 GSVEQVRLLLAHEVDVDCQTASG-YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431
           G  E  ++LLA   +V+ +   G  TPL+ A+     D+  LLL H AD N     G   
Sbjct: 249 GYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA 308

Query: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491
           L +A   G     ++LL+ GA ++     G TPL  AA      VAR+L+   A  N H 
Sbjct: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368

Query: 492 AEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
            E K + L +A Y GH+ +V+ L   GA+ + +   + T L  A   G V   + LL SG
Sbjct: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428

Query: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
           A  +    S   PL  AA  G   +  +L+  GA+LE    +G+TPL  AA +GH E++ 
Sbjct: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488

Query: 611 LLAESHANMGA-LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669
           LL    AN+ A       T L LA   G   V   L++ GAD    E    TPL  A Q 
Sbjct: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLMEASQE 545

Query: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729
                V  LL   ANVHA    G T    A   G+T +  VL++AGA L+ +     TPL
Sbjct: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 605

Query: 730 QLALRSRKQGIMSFLEGKEPSV 751
             A R+     + FL  K  +V
Sbjct: 606 MKAARAGHLCTVQFLISKGANV 627



 Score =  151 bits (382), Expect = 2e-36
 Identities = 126/415 (30%), Positives = 186/415 (44%), Gaps = 33/415 (7%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
           +TPL    + G ++ V+LLL H+ DV+ Q+A+G T L  A      D+  +LL  GA+  
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332

Query: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENVARLLV 481
             +E+G  PL  AA  G    AR+LLDHGA ++    E   + L LA      ++ R L+
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
              AD      E  T L  A   GHV + +LL   GA+++    +  +PL LA   G V 
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW------- 594
               L++ GA  + ++  GY PL  AA  G   +  +LL  GA++   T +         
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 595 ------------------------TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
                                   TPL  A+ +GHLE++  L  S AN+ A  A   T L
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572

Query: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH-ARN 689
             A  +G   V   LLQ GAD     + G TPL  A +     +V  L+   ANV+ A  
Sbjct: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632

Query: 690 KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
               T   LA   G+ A++++L+  GA    +     T L  A +     ++S+L
Sbjct: 633 NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687



 Score =  144 bits (364), Expect = 2e-34
 Identities = 116/365 (31%), Positives = 171/365 (46%), Gaps = 38/365 (10%)

Query: 386  VDVDCQTASGY-TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTA 444
            VD+D  T S + T L +A      +L ++L+A  A     D+ G+ PL  AA  G  G  
Sbjct: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104

Query: 445  RLLLDHGACVDAQ-EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAY 503
             +LLD G  ++AQ ER   TPL LA     + V  LL++R A+         TPL +AA 
Sbjct: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164

Query: 504  FGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP 563
             G+V+++K+L + GAE+     N RT   L +                           P
Sbjct: 1165 GGYVNIIKILLNAGAEI-----NSRTGSKLGI--------------------------SP 1193

Query: 564  LHTAAARGKYLICKMLLRYGASL--ELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGA 621
            L  AA  G     K+LL  G+ +  ++ T++  T L LA ++G  E++ LL +  AN+  
Sbjct: 1194 LMLAAMNGHVPAVKLLLDMGSDINAQIETNRN-TALTLACFQGRAEVVSLLLDRKANVEH 1252

Query: 622  LGAVNWTPLHLAARHGEEAVVSALLQCGADPNA--AEQSGWTPLHLAVQRSTFLSVINLL 679
                  TPL  AA  G   V   LL  GAD NA     S  T L +A  +  +     L+
Sbjct: 1253 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1312

Query: 680  EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQG 739
               A++  RNK G TP  LA+  G+  ++++LV+AGA +D  D    TPL  A R     
Sbjct: 1313 HRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVK 1372

Query: 740  IMSFL 744
            ++ +L
Sbjct: 1373 VVQYL 1377



 Score =  134 bits (336), Expect = 4e-31
 Identities = 106/330 (32%), Positives = 157/330 (47%), Gaps = 7/330 (2%)

Query: 361  NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
            N  T L    A G  E V +L+A +  ++ +   G+TPL++AA      +  +LL  G D
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113

Query: 421  ANRVDE-DGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
                 E     PL  A   G      LLL  GA  + +    +TPL LAA   + N+ ++
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173

Query: 480  LVSRQADPNLHEAE--GKTPLHVAAYFGHVSLVKLLTSQGAELDAQ-QRNLRTPLHLAVE 536
            L++  A+ N       G +PL +AA  GHV  VKLL   G++++AQ + N  T L LA  
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233

Query: 537  RGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP--THQGW 594
            +G+   +  LL   A  +   ++G  PL  AA+ G   + ++LL  GA +  P       
Sbjct: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293

Query: 595  TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654
            T L +AA KGH +   LL    A++        TPL LA+  G   VV  L+Q GAD +A
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353

Query: 655  AEQSGWTPLHLAVQRSTFLSVINLLEHHAN 684
            A+    TPL ++  R   + V+  L    N
Sbjct: 1354 ADNRKITPL-MSAFRKGHVKVVQYLVKEVN 1382



 Score =  127 bits (318), Expect = 5e-29
 Identities = 115/367 (31%), Positives = 168/367 (45%), Gaps = 9/367 (2%)

Query: 321 NEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRL 380
           NE+    LM++ S  +++ A  L D    +         E K + L     +G ++ VR 
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN----EFKESALTLACYKGHLDMVRF 390

Query: 381 LLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGD 440
           LL    D + +T   +T L+ A  D   ++  LLL  GA  N   +   +PL  AA  G 
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450

Query: 441 DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH-EAEGKTPLH 499
              A LL++ GA ++    EG+TPL  AA+   E +  LL+++ A+ N   E   +T L 
Sbjct: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 510

Query: 500 VAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559
           +A   G   +   L   GA+++       TPL  A + G +  +++LL SGA   A   +
Sbjct: 511 LACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTAT 567

Query: 560 GYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANM 619
           G   L  A   G   +  +LL+ GA LE  +  G TPL  AA  GHL  +  L    AN+
Sbjct: 568 GDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANV 627

Query: 620 GALGAVN-WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINL 678
               A N  T + LA   G  AVV  LL  GADP    + G T L  A +      V  L
Sbjct: 628 NRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687

Query: 679 LEHHANV 685
           L++  NV
Sbjct: 688 LDYPNNV 694



 Score =  117 bits (293), Expect = 4e-26
 Identities = 89/289 (30%), Positives = 142/289 (49%), Gaps = 2/289 (0%)

Query: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494
           A  +GD    R LLD G  V+    EG + L LA    +  +A++L++  A+      +G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271

Query: 495 K-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553
             TPL  A+  G++ +VKLL    A++++Q     T L  A   G V  ++ LL  GA  
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331

Query: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ-GWTPLHLAAYKGHLEIIHLL 612
           +  +++G+ PL  AA+ G   + ++LL +GA +   +++   + L LA YKGHL+++  L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391

Query: 613 AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTF 672
            E+ A+         T L  A   G   V   LL  GA  N    S  +PL LA      
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451

Query: 673 LSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
                L+E  AN+   N  G+TP   AA +G+  ++ +L+  GA ++ Q
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 55/161 (34%), Positives = 78/161 (48%), Gaps = 2/161 (1%)

Query: 358  IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
            I  N+ T L     QG  E V LLL  + +V+ +  +G TPL+ AA     ++  +LL  
Sbjct: 1220 IETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1279

Query: 418  GADANR--VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN 475
            GAD N   V       L  AA  G      LL+  GA +D + ++G TPL LA+     +
Sbjct: 1280 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFD 1339

Query: 476  VARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQ 516
            V +LLV   AD +  +    TPL  A   GHV +V+ L  +
Sbjct: 1340 VVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 39/134 (29%), Positives = 60/134 (44%), Gaps = 1/134 (0%)

Query: 628  TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687
            T L LA   G E +VS L+   A     ++ G+TPL LA        V  LL+   ++ A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 688  RN-KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEG 746
            ++ +   TP  LA   G   ++ +L+  GA  + ++    TPL LA       I+  L  
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176

Query: 747  KEPSVATLGGSKPG 760
                + +  GSK G
Sbjct: 1177 AGAEINSRTGSKLG 1190


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  154 bits (389), Expect = 3e-37
 Identities = 123/353 (34%), Positives = 167/353 (47%), Gaps = 6/353 (1%)

Query: 373 GSVEQVRLLLAHEVDVDCQTASG-YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431
           G  E  ++LLA   +V+ +   G  TPL+ A+     D+  LLL H AD N     G   
Sbjct: 249 GYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA 308

Query: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491
           L +A   G     ++LL+ GA ++     G TPL  AA      VAR+L+   A  N H 
Sbjct: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368

Query: 492 AEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
            E K + L +A Y GH+ +V+ L   GA+ + +   + T L  A   G V   + LL SG
Sbjct: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428

Query: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
           A  +    S   PL  AA  G   +  +L+  GA+LE    +G+TPL  AA +GH E++ 
Sbjct: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488

Query: 611 LLAESHANMGA-LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669
           LL    AN+ A       T L LA   G   V   L++ GAD    E    TPL  A Q 
Sbjct: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLMEASQE 545

Query: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722
                V  LL   ANVHA    G T    A   G+T +  VL++AGA LD Q+
Sbjct: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 598



 Score =  133 bits (335), Expect = 5e-31
 Identities = 103/326 (31%), Positives = 148/326 (45%), Gaps = 32/326 (9%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
           +TPL    + G ++ V+LLL H+ DV+ Q+A+G T L  A      D+  +LL  GA+  
Sbjct: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332

Query: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENVARLLV 481
             +E+G  PL  AA  G    AR+LLDHGA ++    E   + L LA      ++ R L+
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392

Query: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
              AD      E  T L  A   GHV + +LL   GA+++    +  +PL LA   G V 
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452

Query: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW------- 594
               L++ GA  + ++  GY PL  AA  G   +  +LL  GA++   T +         
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 595 ------------------------TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
                                   TPL  A+ +GHLE++  L  S AN+ A  A   T L
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572

Query: 631 HLAARHGEEAVVSALLQCGADPNAAE 656
             A  +G   V   LLQ GAD +  E
Sbjct: 573 TYACENGHTDVADVLLQAGADLDKQE 598



 Score =  131 bits (330), Expect = 2e-30
 Identities = 110/365 (30%), Positives = 173/365 (47%), Gaps = 6/365 (1%)

Query: 371 AQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA-HGADANRVDEDGW 429
           + G V  VR LL     V+  T  G + L +A      +L  +LLA H    +R ++   
Sbjct: 214 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 273

Query: 430 APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNL 489
            PL  A+  G     +LLL H A V++Q   G T L  A    F ++ ++L++  A+   
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333

Query: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLR-TPLHLAVERGKVRAIQHLLK 548
           H   G TPL  AA  GHV + ++L   GA ++      + + L LA  +G +  ++ LL+
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 549 SGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEI 608
           +GA  +      +  L  A   G   + ++LL  GA + +P     +PL LAA  GH+E+
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453

Query: 609 IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA-AEQSGWTPLHLAV 667
             LL E  AN+  +    +TPL  AAR G E +V+ LL  GA+ NA  E++  T L LA 
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513

Query: 668 QRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCT 727
                     L++  A++        TP   A+ +G+  ++K L+ +GA +        T
Sbjct: 514 CGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDT 570

Query: 728 PLQLA 732
            L  A
Sbjct: 571 ALTYA 575



 Score =  117 bits (293), Expect = 4e-26
 Identities = 89/289 (30%), Positives = 142/289 (49%), Gaps = 2/289 (0%)

Query: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494
           A  +GD    R LLD G  V+    EG + L LA    +  +A++L++  A+      +G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271

Query: 495 K-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553
             TPL  A+  G++ +VKLL    A++++Q     T L  A   G V  ++ LL  GA  
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331

Query: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ-GWTPLHLAAYKGHLEIIHLL 612
           +  +++G+ PL  AA+ G   + ++LL +GA +   +++   + L LA YKGHL+++  L
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391

Query: 613 AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTF 672
            E+ A+         T L  A   G   V   LL  GA  N    S  +PL LA      
Sbjct: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451

Query: 673 LSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
                L+E  AN+   N  G+TP   AA +G+  ++ +L+  GA ++ Q
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 78/268 (29%), Positives = 124/268 (46%), Gaps = 8/268 (2%)

Query: 321 NEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRL 380
           NE+    LM++ S  +++ A  L D    +         E K + L     +G ++ VR 
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN----EFKESALTLACYKGHLDMVRF 390

Query: 381 LLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGD 440
           LL    D + +T   +T L+ A  D   ++  LLL  GA  N   +   +PL  AA  G 
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450

Query: 441 DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH-EAEGKTPLH 499
              A LL++ GA ++    EG+TPL  AA+   E +  LL+++ A+ N   E   +T L 
Sbjct: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 510

Query: 500 VAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559
           +A   G   +   L   GA+++       TPL  A + G +  +++LL SGA   A   +
Sbjct: 511 LACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTAT 567

Query: 560 GYGPLHTAAARGKYLICKMLLRYGASLE 587
           G   L  A   G   +  +LL+ GA L+
Sbjct: 568 GDTALTYACENGHTDVADVLLQAGADLD 595



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 22/63 (34%), Positives = 35/63 (55%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           TPL     +G +E V+ LLA   +V   TA+G T L  A ++   D+  +LL  GAD ++
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 596

Query: 424 VDE 426
            ++
Sbjct: 597 QED 599


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  154 bits (389), Expect = 3e-37
 Identities = 123/353 (34%), Positives = 167/353 (47%), Gaps = 6/353 (1%)

Query: 373 GSVEQVRLLLAHEVDVDCQTASG-YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431
           G  E  ++LLA   +V+ +   G  TPL+ A+     D+  LLL H AD N     G   
Sbjct: 238 GYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA 297

Query: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491
           L +A   G     ++LL+ GA ++     G TPL  AA      VAR+L+   A  N H 
Sbjct: 298 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 357

Query: 492 AEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
            E K + L +A Y GH+ +V+ L   GA+ + +   + T L  A   G V   + LL SG
Sbjct: 358 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 417

Query: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
           A  +    S   PL  AA  G   +  +L+  GA+LE    +G+TPL  AA +GH E++ 
Sbjct: 418 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 477

Query: 611 LLAESHANMGA-LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669
           LL    AN+ A       T L LA   G   V   L++ GAD    E    TPL  A Q 
Sbjct: 478 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLMEASQE 534

Query: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722
                V  LL   ANVHA    G T    A   G+T +  VL++AGA LD Q+
Sbjct: 535 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 587



 Score =  133 bits (335), Expect = 5e-31
 Identities = 103/326 (31%), Positives = 148/326 (45%), Gaps = 32/326 (9%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
           +TPL    + G ++ V+LLL H+ DV+ Q+A+G T L  A      D+  +LL  GA+  
Sbjct: 262 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 321

Query: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENVARLLV 481
             +E+G  PL  AA  G    AR+LLDHGA ++    E   + L LA      ++ R L+
Sbjct: 322 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 381

Query: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
              AD      E  T L  A   GHV + +LL   GA+++    +  +PL LA   G V 
Sbjct: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441

Query: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW------- 594
               L++ GA  + ++  GY PL  AA  G   +  +LL  GA++   T +         
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501

Query: 595 ------------------------TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
                                   TPL  A+ +GHLE++  L  S AN+ A  A   T L
Sbjct: 502 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561

Query: 631 HLAARHGEEAVVSALLQCGADPNAAE 656
             A  +G   V   LLQ GAD +  E
Sbjct: 562 TYACENGHTDVADVLLQAGADLDKQE 587



 Score =  131 bits (330), Expect = 2e-30
 Identities = 110/365 (30%), Positives = 173/365 (47%), Gaps = 6/365 (1%)

Query: 371 AQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA-HGADANRVDEDGW 429
           + G V  VR LL     V+  T  G + L +A      +L  +LLA H    +R ++   
Sbjct: 203 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 262

Query: 430 APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNL 489
            PL  A+  G     +LLL H A V++Q   G T L  A    F ++ ++L++  A+   
Sbjct: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322

Query: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLR-TPLHLAVERGKVRAIQHLLK 548
           H   G TPL  AA  GHV + ++L   GA ++      + + L LA  +G +  ++ LL+
Sbjct: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382

Query: 549 SGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEI 608
           +GA  +      +  L  A   G   + ++LL  GA + +P     +PL LAA  GH+E+
Sbjct: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 442

Query: 609 IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA-AEQSGWTPLHLAV 667
             LL E  AN+  +    +TPL  AAR G E +V+ LL  GA+ NA  E++  T L LA 
Sbjct: 443 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 502

Query: 668 QRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCT 727
                     L++  A++        TP   A+ +G+  ++K L+ +GA +        T
Sbjct: 503 CGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDT 559

Query: 728 PLQLA 732
            L  A
Sbjct: 560 ALTYA 564



 Score =  118 bits (295), Expect = 2e-26
 Identities = 106/355 (29%), Positives = 165/355 (46%), Gaps = 24/355 (6%)

Query: 388 VDCQTASGYTPLLIAAQDQQPDL---------CALLLAHGA----------DANRVDEDG 428
           VD +T +    LL AA    P++         CAL  A  A          +A +VD   
Sbjct: 138 VDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRS 197

Query: 429 WAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPN 488
            A    A  +GD    R LLD G  V+    EG + L LA    +  +A++L++  A+  
Sbjct: 198 LAE---ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 254

Query: 489 LHEAEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL 547
               +G  TPL  A+  G++ +VKLL    A++++Q     T L  A   G V  ++ LL
Sbjct: 255 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 314

Query: 548 KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ-GWTPLHLAAYKGHL 606
             GA  +  +++G+ PL  AA+ G   + ++LL +GA +   +++   + L LA YKGHL
Sbjct: 315 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374

Query: 607 EIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLA 666
           +++  L E+ A+         T L  A   G   V   LL  GA  N    S  +PL LA
Sbjct: 375 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 434

Query: 667 VQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
                      L+E  AN+   N  G+TP   AA +G+  ++ +L+  GA ++ Q
Sbjct: 435 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 489



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 78/268 (29%), Positives = 124/268 (46%), Gaps = 8/268 (2%)

Query: 321 NEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRL 380
           NE+    LM++ S  +++ A  L D    +         E K + L     +G ++ VR 
Sbjct: 324 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN----EFKESALTLACYKGHLDMVRF 379

Query: 381 LLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGD 440
           LL    D + +T   +T L+ A  D   ++  LLL  GA  N   +   +PL  AA  G 
Sbjct: 380 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 439

Query: 441 DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH-EAEGKTPLH 499
              A LL++ GA ++    EG+TPL  AA+   E +  LL+++ A+ N   E   +T L 
Sbjct: 440 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 499

Query: 500 VAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559
           +A   G   +   L   GA+++       TPL  A + G +  +++LL SGA   A   +
Sbjct: 500 LACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTAT 556

Query: 560 GYGPLHTAAARGKYLICKMLLRYGASLE 587
           G   L  A   G   +  +LL+ GA L+
Sbjct: 557 GDTALTYACENGHTDVADVLLQAGADLD 584



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 22/63 (34%), Positives = 35/63 (55%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           TPL     +G +E V+ LLA   +V   TA+G T L  A ++   D+  +LL  GAD ++
Sbjct: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 585

Query: 424 VDE 426
            ++
Sbjct: 586 QED 588


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  154 bits (388), Expect = 4e-37
 Identities = 115/334 (34%), Positives = 164/334 (49%), Gaps = 13/334 (3%)

Query: 359 YENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASG----YTPLLIAAQDQQPDLCALL 414
           YE + TPLHF VA G+V  V +L ++E    C   S      TPL  AA      +  LL
Sbjct: 219 YEGR-TPLHFAVADGNVTVVDVLTSYE---SCNITSYDNLFRTPLHWAALLGHAQIVHLL 274

Query: 415 LAHGADAN-RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNF 473
           L          D  G  PLH+AAQ+    T ++ L H +  D  + EG T    AA    
Sbjct: 275 LERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGS 334

Query: 474 ENVARLLVSRQADPNLHEAE--GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPL 531
           ++V R ++S ++D +++ A+  G T LH AA  GHVS VKLL    A++DA      TPL
Sbjct: 335 DDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPL 394

Query: 532 HLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTH 591
             A E G    IQ L+K GA  D +DQ G+  LH AA  G   +C++L+    +  +  +
Sbjct: 395 FRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDY 454

Query: 592 QGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGAD 651
            G TPL  AAY G++  + +L E++A+         T LH +  +G    +  LL   A 
Sbjct: 455 AGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAF 514

Query: 652 PNAAE--QSGWTPLHLAVQRSTFLSVINLLEHHA 683
           PN  E  +  +TPL  A+       +  +LEH A
Sbjct: 515 PNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score =  139 bits (351), Expect = 8e-33
 Identities = 135/497 (27%), Positives = 221/497 (44%), Gaps = 66/497 (13%)

Query: 304 LARKVSCKLSLRQPG-EVNE-DISQEL---MDSDSGNYLKRALQLSDRKNLVPRDEELCI 358
           LA ++ C  +L + G +VN+ D SQ     + +  GNY    L L+ R N + +D E   
Sbjct: 57  LADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLE--- 113

Query: 359 YENKVTPLHFLVAQGSVEQVRLLLAHEV--DVDCQTASGYTPLLIAAQDQQPDLCALLLA 416
              ++TPLH      S + + LLL      +VD Q  +  T L  +A    P+   LL+ 
Sbjct: 114 ---EMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK 170

Query: 417 HGADANRVDEDGWAPLHFAAQNGDDG---TARLLLDHG---ACVDAQEREGWTPLHLAAQ 470
           H ++    D +G  PLH+AA + D     T R +LD     + ++ Q+ EG TPLH A  
Sbjct: 171 HDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVA 230

Query: 471 NNFENVARLLVSRQA-DPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAE----LDAQQR 525
           +    V  +L S ++ +   ++   +TPLH AA  GH  +V LL  +        D+Q  
Sbjct: 231 DGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGA 290

Query: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS 585
              TPLH A +      ++  LK  +V D  D  G      AA +G   + + +L   + 
Sbjct: 291 ---TPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347

Query: 586 LEL--PTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVS 643
           +++      G T LH AA  GH+  + LL E++A + A   +  TPL  A   G + V+ 
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407

Query: 644 ALLQCGA---------------------------------DPNAAEQSGWTPLHLAVQRS 670
            L++ GA                                 +PN  + +G TPL  A    
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467

Query: 671 TFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA---QLDVQDGVSCT 727
               +  L+E++A+ + ++K G T  H +   G    +K+L++  A   Q++  +    T
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQME-NNEERYT 526

Query: 728 PLQLALRSRKQGIMSFL 744
           PL  AL   +  ++ F+
Sbjct: 527 PLDYALLGERHEVIQFM 543



 Score =  130 bits (327), Expect = 5e-30
 Identities = 110/383 (28%), Positives = 174/383 (45%), Gaps = 17/383 (4%)

Query: 379 RLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQN 438
           RL++ +    D +   G TPL+      + D    LL  GAD N+ D      LH AAQ 
Sbjct: 32  RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91

Query: 439 GDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQA--DPNLHEAEGKT 496
           G+    +LLL   A    ++ E  TPLHL  ++       LL+   A  + +  +   +T
Sbjct: 92  GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151

Query: 497 PLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAV---ERGKVRAIQHLLKSGAVP 553
            LH +AY+ +   VKLL    + +       + PLH A    +   V  ++ +L +    
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211

Query: 554 DAL---DQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW--TPLHLAAYKGHLEI 608
             L   D  G  PLH A A G   +  +L  Y  S  + ++     TPLH AA  GH +I
Sbjct: 212 SLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPLHWAALLGHAQI 270

Query: 609 IHLLAESHANMGAL--GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLA 666
           +HLL E + + G +   +   TPLH AA+      V   L+  +  + ++  G T    A
Sbjct: 271 VHLLLERNKS-GTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWA 329

Query: 667 VQRST--FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGV 724
             + +   L  +  L+   +++  +K G T  H AAL G+ + +K+L+E  AQ+D  D +
Sbjct: 330 AGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVM 389

Query: 725 SCTPLQLALR-SRKQGIMSFLEG 746
             TPL  A     K  I + ++G
Sbjct: 390 KHTPLFRACEMGHKDVIQTLIKG 412



 Score =  117 bits (294), Expect = 3e-26
 Identities = 121/446 (27%), Positives = 175/446 (39%), Gaps = 82/446 (18%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           TPL + V    ++    LL    DV+    S  T L +AAQ        LLL   A+  +
Sbjct: 50  TPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQ 109

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGAC--VDAQEREGWTPLHLAAQNNFENVARLLV 481
            D +   PLH   ++       LLL   A   VD Q++   T LH +A  N     +LL+
Sbjct: 110 KDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLI 169

Query: 482 SRQA--------------------DP-------------------NLHEAEGKTPLHVAA 502
              +                    DP                   N  + EG+TPLH A 
Sbjct: 170 KHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAV 229

Query: 503 YFGHVSLVKLLTS-QGAELDAQQRNLRTPLHLAVERGKVRAIQHLL---KSGAVPDALDQ 558
             G+V++V +LTS +   + +     RTPLH A   G  + +  LL   KSG +P   D 
Sbjct: 230 ADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPS--DS 287

Query: 559 SGYGPLHTAA-------------------------------ARGK----YLICKMLLRYG 583
            G  PLH AA                               A GK     L   + L+  
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347

Query: 584 ASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVS 643
             + +    G T LH AA  GH+  + LL E++A + A   +  TPL  A   G + V+ 
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407

Query: 644 ALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKG 703
            L++ GA  +  +Q G + LH A           L+E+  N + ++  G TP   AA  G
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467

Query: 704 NTAILKVLVEAGAQLDVQDGVSCTPL 729
               + VL+E  A  ++QD    T L
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTAL 493



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 84/301 (27%), Positives = 127/301 (42%), Gaps = 51/301 (16%)

Query: 498 LHVAAYFGHV-SLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDAL 556
           +H AA  G   +L +L+    A  D + +  RTPL   V   ++     LLK+GA  +  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 557 DQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL----------------- 599
           D S    LH AA +G Y   K+LL   A+      +  TPLHL                 
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 600 ------------------AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAV 641
                             +AY  + E + LL +  +N+G        PLH AA H + + 
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 642 VSALLQCGADP-------NAAEQSGWTPLHLAVQRSTFLSVINLLEHH--ANVHARNKVG 692
           V   ++C  D        N  +  G TPLH AV     ++V+++L  +   N+ + + + 
Sbjct: 198 VHT-VRCILDAAPTESLLNWQDYEGRTPLHFAVADGN-VTVVDVLTSYESCNITSYDNLF 255

Query: 693 WTPAHLAALKGNTAILKVLVEAGAQLDV-QDGVSCTPLQLALRSR-KQGIMSFLEGKEPS 750
            TP H AAL G+  I+ +L+E      +  D    TPL  A +S   + +  FL  K PS
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL--KHPS 313

Query: 751 V 751
           V
Sbjct: 314 V 314



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 65/232 (28%), Positives = 104/232 (44%), Gaps = 9/232 (3%)

Query: 526 NLRTPLHLAVERGKVRAIQHLLK-SGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGA 584
           +L + +H A   G   A+Q L+  + A+ D  DQ G  PL       +      LL+ GA
Sbjct: 13  SLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGA 72

Query: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644
            +    H   T LHLAA KG+   + LL    AN         TPLHL  RH     ++ 
Sbjct: 73  DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132

Query: 645 LLQCGA--DPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAA-L 701
           LL+  A  + +  +++  T LH +   +    V  L++H +N+   +  G  P H AA  
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192

Query: 702 KGNTAI--LKVLVEAG---AQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKE 748
           K  +A+  ++ +++A    + L+ QD    TPL  A+      ++  L   E
Sbjct: 193 KDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYE 244


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  154 bits (388), Expect = 4e-37
 Identities = 115/334 (34%), Positives = 164/334 (49%), Gaps = 13/334 (3%)

Query: 359 YENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASG----YTPLLIAAQDQQPDLCALL 414
           YE + TPLHF VA G+V  V +L ++E    C   S      TPL  AA      +  LL
Sbjct: 219 YEGR-TPLHFAVADGNVTVVDVLTSYE---SCNITSYDNLFRTPLHWAALLGHAQIVHLL 274

Query: 415 LAHGADAN-RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNF 473
           L          D  G  PLH+AAQ+    T ++ L H +  D  + EG T    AA    
Sbjct: 275 LERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGS 334

Query: 474 ENVARLLVSRQADPNLHEAE--GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPL 531
           ++V R ++S ++D +++ A+  G T LH AA  GHVS VKLL    A++DA      TPL
Sbjct: 335 DDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPL 394

Query: 532 HLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTH 591
             A E G    IQ L+K GA  D +DQ G+  LH AA  G   +C++L+    +  +  +
Sbjct: 395 FRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDY 454

Query: 592 QGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGAD 651
            G TPL  AAY G++  + +L E++A+         T LH +  +G    +  LL   A 
Sbjct: 455 AGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAF 514

Query: 652 PNAAE--QSGWTPLHLAVQRSTFLSVINLLEHHA 683
           PN  E  +  +TPL  A+       +  +LEH A
Sbjct: 515 PNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score =  139 bits (351), Expect = 8e-33
 Identities = 135/497 (27%), Positives = 221/497 (44%), Gaps = 66/497 (13%)

Query: 304 LARKVSCKLSLRQPG-EVNE-DISQEL---MDSDSGNYLKRALQLSDRKNLVPRDEELCI 358
           LA ++ C  +L + G +VN+ D SQ     + +  GNY    L L+ R N + +D E   
Sbjct: 57  LADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLE--- 113

Query: 359 YENKVTPLHFLVAQGSVEQVRLLLAHEV--DVDCQTASGYTPLLIAAQDQQPDLCALLLA 416
              ++TPLH      S + + LLL      +VD Q  +  T L  +A    P+   LL+ 
Sbjct: 114 ---EMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK 170

Query: 417 HGADANRVDEDGWAPLHFAAQNGDDG---TARLLLDHG---ACVDAQEREGWTPLHLAAQ 470
           H ++    D +G  PLH+AA + D     T R +LD     + ++ Q+ EG TPLH A  
Sbjct: 171 HDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVA 230

Query: 471 NNFENVARLLVSRQA-DPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAE----LDAQQR 525
           +    V  +L S ++ +   ++   +TPLH AA  GH  +V LL  +        D+Q  
Sbjct: 231 DGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGA 290

Query: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS 585
              TPLH A +      ++  LK  +V D  D  G      AA +G   + + +L   + 
Sbjct: 291 ---TPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347

Query: 586 LEL--PTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVS 643
           +++      G T LH AA  GH+  + LL E++A + A   +  TPL  A   G + V+ 
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407

Query: 644 ALLQCGA---------------------------------DPNAAEQSGWTPLHLAVQRS 670
            L++ GA                                 +PN  + +G TPL  A    
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467

Query: 671 TFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA---QLDVQDGVSCT 727
               +  L+E++A+ + ++K G T  H +   G    +K+L++  A   Q++  +    T
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQME-NNEERYT 526

Query: 728 PLQLALRSRKQGIMSFL 744
           PL  AL   +  ++ F+
Sbjct: 527 PLDYALLGERHEVIQFM 543



 Score =  130 bits (327), Expect = 5e-30
 Identities = 110/383 (28%), Positives = 174/383 (45%), Gaps = 17/383 (4%)

Query: 379 RLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQN 438
           RL++ +    D +   G TPL+      + D    LL  GAD N+ D      LH AAQ 
Sbjct: 32  RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91

Query: 439 GDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQA--DPNLHEAEGKT 496
           G+    +LLL   A    ++ E  TPLHL  ++       LL+   A  + +  +   +T
Sbjct: 92  GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151

Query: 497 PLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAV---ERGKVRAIQHLLKSGAVP 553
            LH +AY+ +   VKLL    + +       + PLH A    +   V  ++ +L +    
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211

Query: 554 DAL---DQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW--TPLHLAAYKGHLEI 608
             L   D  G  PLH A A G   +  +L  Y  S  + ++     TPLH AA  GH +I
Sbjct: 212 SLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPLHWAALLGHAQI 270

Query: 609 IHLLAESHANMGAL--GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLA 666
           +HLL E + + G +   +   TPLH AA+      V   L+  +  + ++  G T    A
Sbjct: 271 VHLLLERNKS-GTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWA 329

Query: 667 VQRST--FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGV 724
             + +   L  +  L+   +++  +K G T  H AAL G+ + +K+L+E  AQ+D  D +
Sbjct: 330 AGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVM 389

Query: 725 SCTPLQLALR-SRKQGIMSFLEG 746
             TPL  A     K  I + ++G
Sbjct: 390 KHTPLFRACEMGHKDVIQTLIKG 412



 Score =  117 bits (294), Expect = 3e-26
 Identities = 121/446 (27%), Positives = 175/446 (39%), Gaps = 82/446 (18%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           TPL + V    ++    LL    DV+    S  T L +AAQ        LLL   A+  +
Sbjct: 50  TPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQ 109

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGAC--VDAQEREGWTPLHLAAQNNFENVARLLV 481
            D +   PLH   ++       LLL   A   VD Q++   T LH +A  N     +LL+
Sbjct: 110 KDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLI 169

Query: 482 SRQA--------------------DP-------------------NLHEAEGKTPLHVAA 502
              +                    DP                   N  + EG+TPLH A 
Sbjct: 170 KHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAV 229

Query: 503 YFGHVSLVKLLTS-QGAELDAQQRNLRTPLHLAVERGKVRAIQHLL---KSGAVPDALDQ 558
             G+V++V +LTS +   + +     RTPLH A   G  + +  LL   KSG +P   D 
Sbjct: 230 ADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPS--DS 287

Query: 559 SGYGPLHTAA-------------------------------ARGK----YLICKMLLRYG 583
            G  PLH AA                               A GK     L   + L+  
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347

Query: 584 ASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVS 643
             + +    G T LH AA  GH+  + LL E++A + A   +  TPL  A   G + V+ 
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQ 407

Query: 644 ALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKG 703
            L++ GA  +  +Q G + LH A           L+E+  N + ++  G TP   AA  G
Sbjct: 408 TLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGG 467

Query: 704 NTAILKVLVEAGAQLDVQDGVSCTPL 729
               + VL+E  A  ++QD    T L
Sbjct: 468 YINCMAVLMENNADPNIQDKEGRTAL 493



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 84/301 (27%), Positives = 127/301 (42%), Gaps = 51/301 (16%)

Query: 498 LHVAAYFGHV-SLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDAL 556
           +H AA  G   +L +L+    A  D + +  RTPL   V   ++     LLK+GA  +  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 557 DQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL----------------- 599
           D S    LH AA +G Y   K+LL   A+      +  TPLHL                 
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 600 ------------------AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAV 641
                             +AY  + E + LL +  +N+G        PLH AA H + + 
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197

Query: 642 VSALLQCGADP-------NAAEQSGWTPLHLAVQRSTFLSVINLLEHH--ANVHARNKVG 692
           V   ++C  D        N  +  G TPLH AV     ++V+++L  +   N+ + + + 
Sbjct: 198 VHT-VRCILDAAPTESLLNWQDYEGRTPLHFAVADGN-VTVVDVLTSYESCNITSYDNLF 255

Query: 693 WTPAHLAALKGNTAILKVLVEAGAQLDV-QDGVSCTPLQLALRSR-KQGIMSFLEGKEPS 750
            TP H AAL G+  I+ +L+E      +  D    TPL  A +S   + +  FL  K PS
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL--KHPS 313

Query: 751 V 751
           V
Sbjct: 314 V 314



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 65/232 (28%), Positives = 104/232 (44%), Gaps = 9/232 (3%)

Query: 526 NLRTPLHLAVERGKVRAIQHLLK-SGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGA 584
           +L + +H A   G   A+Q L+  + A+ D  DQ G  PL       +      LL+ GA
Sbjct: 13  SLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGA 72

Query: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644
            +    H   T LHLAA KG+   + LL    AN         TPLHL  RH     ++ 
Sbjct: 73  DVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132

Query: 645 LLQCGA--DPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAA-L 701
           LL+  A  + +  +++  T LH +   +    V  L++H +N+   +  G  P H AA  
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192

Query: 702 KGNTAI--LKVLVEAG---AQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKE 748
           K  +A+  ++ +++A    + L+ QD    TPL  A+      ++  L   E
Sbjct: 193 KDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYE 244


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  150 bits (379), Expect = 4e-36
 Identities = 109/375 (29%), Positives = 177/375 (47%)

Query: 370 VAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGW 429
           V + ++  ++ LL    DVD +   G TPL+IAA+    ++   L+ +GA+ N  D D W
Sbjct: 13  VEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW 72

Query: 430 APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNL 489
             L  A++ G       LL  G  ++ ++  GWT L  A      +V  LL+S  A+P++
Sbjct: 73  TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV 132

Query: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS 549
                  P+  AA  GH  +V LL   GA+++   +   TPL  A  +G +  ++HLL  
Sbjct: 133 TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAM 192

Query: 550 GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEII 609
           GA  D    +    L  A   G     K +L+   ++ L    G T L +A+ +GH EI+
Sbjct: 193 GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIV 252

Query: 610 HLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669
             L ++   +        T L  A R G   +V ALLQ  AD +   Q   T L+ AV++
Sbjct: 253 QDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312

Query: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729
                V ++L+ + +     K G TP   A    N  ++++L++ GA++   D    TPL
Sbjct: 313 GNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPL 372

Query: 730 QLALRSRKQGIMSFL 744
            +A+R R + +   L
Sbjct: 373 HIAIRGRSRKLAELL 387



 Score =  148 bits (373), Expect = 2e-35
 Identities = 106/349 (30%), Positives = 163/349 (46%), Gaps = 1/349 (0%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           TPL     QG++E V+ L+ +  + + +    +T L+ A+++    +   LL  G +   
Sbjct: 40  TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEH 99

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
            D  GW  L +A   G      LLL HGA           P+  AA     ++  LL+  
Sbjct: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159

Query: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
            A  N  +  G TPL  AA  GH+  VK L + GA++D +  N  T L +AV+ G  +++
Sbjct: 160 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219

Query: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
           + +LK     +  D+ G   L  A+  G   I + LL  G  + +P   G T L  A   
Sbjct: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRG 279

Query: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663
           GH+EI+  L + +A++   G  N T L+ A   G   +V  +LQC  D     + G TPL
Sbjct: 280 GHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL 339

Query: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLV 712
             A +      V  LL+  A V A +K G TP H+ A++G +  L  L+
Sbjct: 340 IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI-AIRGRSRKLAELL 387



 Score =  113 bits (283), Expect = 6e-25
 Identities = 89/308 (28%), Positives = 141/308 (45%), Gaps = 9/308 (2%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           T L +   +G  + V LLL+H  +          P++ AA     D+  LLL +GA  N 
Sbjct: 106 TALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC 165

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
            D+ G  PL +AA+ G     + LL  GA VD +     T L +A +  +    + ++ R
Sbjct: 166 SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKR 225

Query: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
             + NL + +G T L +A+  GH  +V+ L   G  ++   R+  T L  AV  G V  +
Sbjct: 226 NPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIV 285

Query: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
           + LL+  A  D   Q     L+ A  +G   + + +L+     E+ T  G TPL  A   
Sbjct: 286 RALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKM 345

Query: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGAD------PNAAEQ 657
            ++E++ LL +  A + A+     TPLH+A R     +   LL+   D      PN A  
Sbjct: 346 RNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKA-- 403

Query: 658 SGWTPLHL 665
            G TP ++
Sbjct: 404 -GETPYNI 410



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 64/238 (26%), Positives = 115/238 (48%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
           V P+ +   +G  + V LLL +   V+C    G TPL+ AA+    +    LLA GAD +
Sbjct: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD 197

Query: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482
           +   +    L  A + G   + + +L     V+  +++G T L +A++     + + L+ 
Sbjct: 198 QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD 257

Query: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542
                N+ +  G T L  A   GHV +V+ L  + A++D + ++ +T L+ AVE+G    
Sbjct: 258 AGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATM 317

Query: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
           ++ +L+     +   + G  PL  A       + ++LL  GA +     +G TPLH+A
Sbjct: 318 VRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 69/246 (28%), Positives = 115/246 (46%), Gaps = 3/246 (1%)

Query: 357 CIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA 416
           C  +   TPL +   +G +E V+ LLA   DVD + A+  T L++A +         +L 
Sbjct: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224

Query: 417 HGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENV 476
              + N  D+DG   L  A++ G     + LLD G  V+  +R G T L  A +     +
Sbjct: 225 RNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEI 284

Query: 477 ARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVE 536
            R L+ + AD ++   + KT L+ A   G+ ++V+ +     + +   ++  TPL  A +
Sbjct: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344

Query: 537 RGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRY---GASLELPTHQG 593
              +  ++ LL  GA   A+D+ G  PLH A       + ++LLR    G  L  P   G
Sbjct: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAG 404

Query: 594 WTPLHL 599
            TP ++
Sbjct: 405 ETPYNI 410


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score =  150 bits (378), Expect = 6e-36
 Identities = 113/363 (31%), Positives = 174/363 (47%), Gaps = 21/363 (5%)

Query: 337 LKRALQLSDRKNLVPRDEELC------IYENKV--TPLHFLVAQGSVEQVRLLLAHEVDV 388
           L+R L  + R+N V R +EL          N V    LH+    G  + VRLLL HE  V
Sbjct: 15  LERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74

Query: 389 DCQTASG----------YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQN 438
           D + A G             LL++A      +  +L+  GA  +   +DG   LH AAQ 
Sbjct: 75  DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQK 134

Query: 439 GDDGTARLLLD--HGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKT 496
           G       +++      +D  ++ G T  H AA++   +    LV    D N+ + EG T
Sbjct: 135 GHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNT 194

Query: 497 PLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDAL 556
            LH+AA  GH+++++ L   G +L+ Q     T LH A        +Q LL++G+  +AL
Sbjct: 195 ALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNAL 254

Query: 557 DQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESH 616
            Q     LH AA  G   + ++L+  G    +  HQG +PLHLA       ++ LL  S 
Sbjct: 255 TQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSD 314

Query: 617 ANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVI 676
           +++ A+     TPLHLAA H  + +   LL  G D N  ++ G T L +AV RS  +S++
Sbjct: 315 SDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAV-RSNHVSLV 373

Query: 677 NLL 679
           +++
Sbjct: 374 DMI 376



 Score =  143 bits (360), Expect = 7e-34
 Identities = 104/329 (31%), Positives = 157/329 (47%), Gaps = 12/329 (3%)

Query: 428 GWAPLHFAAQNGDDGTARLLLDHGACVDAQEREG----------WTPLHLAAQNNFENVA 477
           G   LH+AA  G +   RLLL+H A VD ++  G             L L+A      + 
Sbjct: 48  GRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRIL 107

Query: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTS--QGAELDAQQRNLRTPLHLAV 535
           ++LV+  A  +    +G T LH AA  GHV ++  +    +   LD   +  RT  H A 
Sbjct: 108 QILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAA 167

Query: 536 ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWT 595
           E G++ A+  L+ SG   +  D+ G   LH AA RG   + + L+  G  LE    +G T
Sbjct: 168 EHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLT 227

Query: 596 PLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAA 655
            LH AA   H + + LL  + + + AL   N + LH AA  G E V   L+  G   N  
Sbjct: 228 ALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVV 287

Query: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAG 715
           +  G +PLHLAV+ +    V  L+   ++V+A +    TP HLAA      I  +L+ AG
Sbjct: 288 DHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAG 347

Query: 716 AQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
             L+++D    T L +A+RS    ++  +
Sbjct: 348 VDLNLRDKQGKTALAVAVRSNHVSLVDMI 376



 Score =  105 bits (262), Expect = 2e-22
 Identities = 57/186 (30%), Positives = 100/186 (53%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           T LH    +G +  ++ L+   +D++ Q A G T L  AA    PD   LLL  G+  N 
Sbjct: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
           + +   + LH+AA +G +  +R+L+  G C +  + +G +PLHLA ++NF  + RLL++ 
Sbjct: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313

Query: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
            +D N  +   +TPLH+AA      +  +L   G +L+ + +  +T L +AV    V  +
Sbjct: 314 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLV 373

Query: 544 QHLLKS 549
             ++K+
Sbjct: 374 DMIIKA 379



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 93/314 (29%), Positives = 134/314 (42%), Gaps = 20/314 (6%)

Query: 456 AQEREGWTPL----HLAAQNNFENVARL--LVSRQADPNLHEAEGKTPLHVAAYFGHVSL 509
           A E +G  PL    H AA+ N  NV R+  L+ R+ +       G+  LH AA  GH   
Sbjct: 6   AWETDGLLPLERQLHEAARQN--NVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQA 63

Query: 510 VKLLTSQGAELDAQ-------QRNL---RTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559
           V+LL    A +D +       +  L      L L+   G +R +Q L+ SGA      + 
Sbjct: 64  VRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKD 123

Query: 560 GYGPLHTAAARGKYLICKMLLR--YGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHA 617
           G   LH AA +G   +   ++      +L+     G T  H AA  G L+ +  L  S  
Sbjct: 124 GLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGC 183

Query: 618 NMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN 677
           +         T LHLAA  G  AV+  L+  G D       G T LH A   S    V  
Sbjct: 184 DHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQL 243

Query: 678 LLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRK 737
           LL   + V+A  +   +  H AAL G+  + +VL+ AG   +V D    +PL LA+R   
Sbjct: 244 LLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNF 303

Query: 738 QGIMSFLEGKEPSV 751
             ++  L   +  V
Sbjct: 304 PALVRLLINSDSDV 317



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 74/261 (28%), Positives = 117/261 (44%), Gaps = 2/261 (0%)

Query: 357 CIYENKVTPLHFLVAQGSVEQVRLLLA--HEVDVDCQTASGYTPLLIAAQDQQPDLCALL 414
           C  ++ +T LH    +G V  +  ++    +V +D     G T    AA+  Q D    L
Sbjct: 119 CESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFL 178

Query: 415 LAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFE 474
           +  G D N  D++G   LH AA  G     + L+D G  ++ Q  EG T LH AA  +  
Sbjct: 179 VGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHP 238

Query: 475 NVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLA 534
           +  +LL+   +  N    +  + LH AA  G   + ++L   G   +       +PLHLA
Sbjct: 239 DCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLA 298

Query: 535 VERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW 594
           V       ++ L+ S +  +A+D     PLH AA      I  MLL  G  L L   QG 
Sbjct: 299 VRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGK 358

Query: 595 TPLHLAAYKGHLEIIHLLAES 615
           T L +A    H+ ++ ++ ++
Sbjct: 359 TALAVAVRSNHVSLVDMIIKA 379


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score =  144 bits (363), Expect = 3e-34
 Identities = 104/309 (33%), Positives = 144/309 (46%), Gaps = 11/309 (3%)

Query: 428 GWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADP 487
           GW  L  A   G  G    LL  GA V+ ++  G TPLHLA       + RLL+ R A  
Sbjct: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100

Query: 488 NLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL 547
              +  G+T LH AA+ GH  + +LL  +GA   A+     TPLH A   G       LL
Sbjct: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160

Query: 548 KS----GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
           ++     A  +A D  G+   H AAA G+  + ++L   GA L+         L +AA  
Sbjct: 161 EAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAA 213

Query: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663
           G    +  L    A + A      T L LAA  G    +  LL  GADP   ++ G + L
Sbjct: 214 GRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSAL 273

Query: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723
           H A  R   L+V  L+   A V AR+ +G TP H A+ +G+  +   L++ GAQ+D    
Sbjct: 274 HRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGW 333

Query: 724 VSCTPLQLA 732
           +  TPL LA
Sbjct: 334 LRKTPLHLA 342



 Score =  142 bits (358), Expect = 1e-33
 Identities = 107/298 (35%), Positives = 140/298 (46%), Gaps = 11/298 (3%)

Query: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
           TPLH  V +G    VRLLL     V     +G T L  AA      +  LLL  GA A  
Sbjct: 76  TPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAA 135

Query: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHG----ACVDAQEREGWTPLHLAAQNNFENVARL 479
               G  PLH+AA  G    A  LL+      A  +A++  GWT  H AA      V  L
Sbjct: 136 RSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLEL 195

Query: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
           L +  A  +         L VAA  G  + ++ L ++GA +DA+     T L LA   G+
Sbjct: 196 LAAGGAGLD-------GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGR 248

Query: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
            + I+ LL  GA P   D+ G   LH AAARG  L  ++L+  GA ++     G TPLH 
Sbjct: 249 SQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHH 308

Query: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657
           A+ +GH+E+   L +  A + A G +  TPLHLAA  G    V  LL  GA P    Q
Sbjct: 309 ASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366



 Score =  141 bits (355), Expect = 3e-33
 Identities = 119/328 (36%), Positives = 156/328 (47%), Gaps = 17/328 (5%)

Query: 370 VAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGW 429
           V +G    V  LL     V+ +  +G TPL +A       L  LLL  GA    VD  G 
Sbjct: 49  VWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGR 108

Query: 430 APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA-RLLVSRQADPN 488
             LH AA +G    A LLL  GA   A+   G TPLH AA      +A RLL +    P 
Sbjct: 109 TALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPA 168

Query: 489 LHEAE---GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQH 545
             EAE   G T  H AA  G +++++LL + GA LD         L +A   G+  A++ 
Sbjct: 169 AAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LLVAAAAGRGAALRF 221

Query: 546 LLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGH 605
           LL  GA  DA D +G   L  AAA G+    ++LL +GA   +    G + LH AA +GH
Sbjct: 222 LLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGH 281

Query: 606 LEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW---TP 662
           L  + LL    A + A   +  TPLH A+R G   V   LL  GA  +A   +GW   TP
Sbjct: 282 LLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDA---TGWLRKTP 338

Query: 663 LHLAVQRSTFLSVINLLEHHANVHARNK 690
           LHLA +R    +V  LL   A+   R +
Sbjct: 339 LHLAAERGHGPTVGLLLSRGASPTLRTQ 366



 Score =  132 bits (333), Expect = 9e-31
 Identities = 112/326 (34%), Positives = 144/326 (44%), Gaps = 11/326 (3%)

Query: 395 GYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACV 454
           G+  LL A       L   LL  GA     D  G  PLH A   G     RLLL  GA V
Sbjct: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100

Query: 455 DAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV-KLL 513
            A +R G T LH AA +    VA LL+ R A        G TPLH AA  GH  L  +LL
Sbjct: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160

Query: 514 TSQG---AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAAR 570
            + G   A  +A+     T  H A   G++  ++ L   GA  D       G L  AAA 
Sbjct: 161 EAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAA 213

Query: 571 GKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
           G+    + LL  GA ++     G T L LAA  G  + I +L    A+ G       + L
Sbjct: 214 GRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSAL 273

Query: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNK 690
           H AA  G    V  L+  GA+ +A +  G TPLH A +         LL+  A V A   
Sbjct: 274 HRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGW 333

Query: 691 VGWTPAHLAALKGNTAILKVLVEAGA 716
           +  TP HLAA +G+   + +L+  GA
Sbjct: 334 LRKTPLHLAAERGHGPTVGLLLSRGA 359



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 31/99 (31%), Positives = 45/99 (45%)

Query: 659 GWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQL 718
           GW  L  AV R     V  LL   A+V  R+  G TP HLA L+G+  ++++L++ GA +
Sbjct: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100

Query: 719 DVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGS 757
              D    T L  A       +   L  +  S A   G+
Sbjct: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGT 139



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 21/57 (36%), Positives = 26/57 (45%)

Query: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
           +TPLH    +G VE    LL     VD       TPL +AA+        LLL+ GA
Sbjct: 303 LTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.134    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,064,375
Number of Sequences: 37866
Number of extensions: 1248137
Number of successful extensions: 11513
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 816
Number of HSP's successfully gapped in prelim test: 310
Number of HSP's that attempted gapping in prelim test: 2845
Number of HSP's gapped (non-prelim): 4046
length of query: 765
length of database: 18,247,518
effective HSP length: 110
effective length of query: 655
effective length of database: 14,082,258
effective search space: 9223878990
effective search space used: 9223878990
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.