Search of human proteins with 30425394

Search of human proteins with 30425394

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30425394 hypothetical protein LOC128876 [Homo sapiens]
         (747 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30425394 hypothetical protein LOC128876 [Homo sapiens]            1507   0.0  
gi|40254997 hypothetical protein LOC84985 isoform a [Homo sapiens]    251   1e-66
gi|46255017 hypothetical protein LOC84985 isoform b [Homo sapiens]    240   4e-63
gi|61676089 hypothetical protein LOC222584 [Homo sapiens]             195   1e-49
gi|157311635 FAM83H [Homo sapiens]                                    188   2e-47
gi|115392150 hypothetical protein LOC644815 [Homo sapiens]            177   4e-44
gi|116235448 hypothetical protein LOC81610 [Homo sapiens]             176   7e-44
gi|153251792 hypothetical protein LOC54854 [Homo sapiens]             171   2e-42
gi|156564372 hypothetical protein LOC113828 [Homo sapiens]            154   4e-37
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    44   7e-04
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    42   0.002
gi|238859651 pleckstrin homology domain containing family A memb...    41   0.005
gi|46370084 transcription factor 12 isoform b [Homo sapiens]           41   0.005
gi|4507391 transcription factor 12 isoform b [Homo sapiens]            41   0.005
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...    41   0.005
gi|210032509 hypothetical protein LOC100130302 [Homo sapiens]          40   0.006
gi|40807452 peroxisome proliferator-activated receptor gamma, co...    40   0.010
gi|46370082 transcription factor 12 isoform a [Homo sapiens]           40   0.010
gi|46370080 transcription factor 12 isoform a [Homo sapiens]           40   0.010
gi|156564386 deltex 2 isoform b [Homo sapiens]                         39   0.013
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho...    39   0.018
gi|149158690 HLA-B associated transcript-2 [Homo sapiens]              39   0.023
gi|19924099 synapsin I isoform Ia [Homo sapiens]                       39   0.023
gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sap...    39   0.023
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]       39   0.023
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         38   0.030
gi|19924097 synapsin I isoform Ib [Homo sapiens]                       38   0.039
gi|208022661 hypothetical protein LOC57701 [Homo sapiens]              38   0.039
gi|22094135 DOT1-like, histone H3 methyltransferase [Homo sapiens]     37   0.051
gi|163965366 nascent polypeptide-associated complex alpha subuni...    37   0.051

>gi|30425394 hypothetical protein LOC128876 [Homo sapiens]
          Length = 747

 Score = 1507 bits (3901), Expect = 0.0
 Identities = 747/747 (100%), Positives = 747/747 (100%)

Query: 1   MFGGPGPGVLGAQGMAGPLRGRVEELKLPWWRESSPLVLRHSEAARLAADALLERGEAAY 60
           MFGGPGPGVLGAQGMAGPLRGRVEELKLPWWRESSPLVLRHSEAARLAADALLERGEAAY
Sbjct: 1   MFGGPGPGVLGAQGMAGPLRGRVEELKLPWWRESSPLVLRHSEAARLAADALLERGEAAY 60

Query: 61  LRVISEERELPFLSALDVDYMTSHVRGGPELSEAQGQEASGPDRLSLLSEVTSGTYFPMA 120
           LRVISEERELPFLSALDVDYMTSHVRGGPELSEAQGQEASGPDRLSLLSEVTSGTYFPMA
Sbjct: 61  LRVISEERELPFLSALDVDYMTSHVRGGPELSEAQGQEASGPDRLSLLSEVTSGTYFPMA 120

Query: 121 SDIDPPDLDLGWPEVPQATGFSPTQAVVHFQRDKAKNIKDLLRFLFSQAHTVVAVVMDIF 180
           SDIDPPDLDLGWPEVPQATGFSPTQAVVHFQRDKAKNIKDLLRFLFSQAHTVVAVVMDIF
Sbjct: 121 SDIDPPDLDLGWPEVPQATGFSPTQAVVHFQRDKAKNIKDLLRFLFSQAHTVVAVVMDIF 180

Query: 181 TDMELLCDLMEASSRRGVPVYLLLAQEHLRHFLEMCYKMDLNGEHLPNMRVRSTCGDTYC 240
           TDMELLCDLMEASSRRGVPVYLLLAQEHLRHFLEMCYKMDLNGEHLPNMRVRSTCGDTYC
Sbjct: 181 TDMELLCDLMEASSRRGVPVYLLLAQEHLRHFLEMCYKMDLNGEHLPNMRVRSTCGDTYC 240

Query: 241 SKAGRRFTGQALEKFVLIDCEQVVAGSYSFTWLCSQAHTSMVLQLRGRIVEDFDREFRCL 300
           SKAGRRFTGQALEKFVLIDCEQVVAGSYSFTWLCSQAHTSMVLQLRGRIVEDFDREFRCL
Sbjct: 241 SKAGRRFTGQALEKFVLIDCEQVVAGSYSFTWLCSQAHTSMVLQLRGRIVEDFDREFRCL 300

Query: 301 YAESQPVEGFCGGEDPLSPRALRPPPVALAFRPDVPSPTSSLPSSTSLSSIKQSPLMGRS 360
           YAESQPVEGFCGGEDPLSPRALRPPPVALAFRPDVPSPTSSLPSSTSLSSIKQSPLMGRS
Sbjct: 301 YAESQPVEGFCGGEDPLSPRALRPPPVALAFRPDVPSPTSSLPSSTSLSSIKQSPLMGRS 360

Query: 361 SYLALPGGGDCSDTGVVSSSLGPARREASGQPSLHRQLSDPNHGSPPGLYRANLGKLGAY 420
           SYLALPGGGDCSDTGVVSSSLGPARREASGQPSLHRQLSDPNHGSPPGLYRANLGKLGAY
Sbjct: 361 SYLALPGGGDCSDTGVVSSSLGPARREASGQPSLHRQLSDPNHGSPPGLYRANLGKLGAY 420

Query: 421 PWSQSSPALNHNSTSPLTLAVGSPLLPRSRPLLQFHRGAPALSRFPENGLPGSQEPSPLR 480
           PWSQSSPALNHNSTSPLTLAVGSPLLPRSRPLLQFHRGAPALSRFPENGLPGSQEPSPLR
Sbjct: 421 PWSQSSPALNHNSTSPLTLAVGSPLLPRSRPLLQFHRGAPALSRFPENGLPGSQEPSPLR 480

Query: 481 GRWVPGTTLETVEEKEKKASPSQSRGQLDLLVPFPRAREVGDPDSGVTPNSGPLRPGEQA 540
           GRWVPGTTLETVEEKEKKASPSQSRGQLDLLVPFPRAREVGDPDSGVTPNSGPLRPGEQA
Sbjct: 481 GRWVPGTTLETVEEKEKKASPSQSRGQLDLLVPFPRAREVGDPDSGVTPNSGPLRPGEQA 540

Query: 541 PEDRRLSPSQADSQLDLLSRALGTGGAPELGSLRPGDRALEDRRLSLNQSRGQSDLLMQY 600
           PEDRRLSPSQADSQLDLLSRALGTGGAPELGSLRPGDRALEDRRLSLNQSRGQSDLLMQY
Sbjct: 541 PEDRRLSPSQADSQLDLLSRALGTGGAPELGSLRPGDRALEDRRLSLNQSRGQSDLLMQY 600

Query: 601 PKAQGSRVPLETNSSARPARRAPDERRQTLGHSQLDLITKFGPFRGEGPGPNGLPISSPA 660
           PKAQGSRVPLETNSSARPARRAPDERRQTLGHSQLDLITKFGPFRGEGPGPNGLPISSPA
Sbjct: 601 PKAQGSRVPLETNSSARPARRAPDERRQTLGHSQLDLITKFGPFRGEGPGPNGLPISSPA 660

Query: 661 RTAGAGSGDEKRLTLGHSKLDLITKYHQLHGARQGTEPGGPKGGHLNGGNSDLVRDEKRL 720
           RTAGAGSGDEKRLTLGHSKLDLITKYHQLHGARQGTEPGGPKGGHLNGGNSDLVRDEKRL
Sbjct: 661 RTAGAGSGDEKRLTLGHSKLDLITKYHQLHGARQGTEPGGPKGGHLNGGNSDLVRDEKRL 720

Query: 721 TLGHSKLDLITKYNKSKFKQLRSRFES 747
           TLGHSKLDLITKYNKSKFKQLRSRFES
Sbjct: 721 TLGHSKLDLITKYNKSKFKQLRSRFES 747


>gi|40254997 hypothetical protein LOC84985 isoform a [Homo sapiens]
          Length = 434

 Score =  251 bits (642), Expect = 1e-66
 Identities = 157/415 (37%), Positives = 225/415 (54%), Gaps = 36/415 (8%)

Query: 17  GPLRGRVEELKLPWWRESSPLVLRHSEAARLAADALLERGEAAYLRVISEERELPFLSAL 76
           G +R R+E++K  W R +       +E+ARLA DALL+ G  AY RV+S+E E+ FLS++
Sbjct: 8   GKIRKRLEDVKSQWVRPARA-DFSDNESARLATDALLDGGSEAYWRVLSQEGEVDFLSSV 66

Query: 77  DVDYMTSHVRGGPELSEAQGQEASGPDRLSLLSEVTSGTYFPMASDIDPPDLDLGWPEVP 136
           +  Y+ +  R  P   +  G   +GP  L   S + SGTYFP+AS+   P L   W    
Sbjct: 67  EAQYIQAQAREPPCPPDTLGGAEAGPKGLDS-SSLQSGTYFPVASEGSEPALLHSWASAE 125

Query: 137 QATGFSPTQAVVHFQRDKAKNIKDLLRFLFSQAHTVVAVVMDIFTDMELLCDLMEASSRR 196
           +      + A V+FQ  K  NI+DL+R   ++   V+ ++MD+FTD+E+ CD++EA+++R
Sbjct: 126 KPYLKEKSSATVYFQTVKHNNIRDLVRRCITRTSQVLVILMDVFTDVEIFCDILEAANKR 185

Query: 197 GVPVYLLLAQEHLRHFLEMCYKMDLNGEHLPNMRVRSTCGDTYCSKAGRRFTGQALEKFV 256
           GV V +LL Q  ++ F EMC K+ ++  HL N+ +RS  G+ YC+K+GR+F GQ  EKF+
Sbjct: 186 GVFVCVLLDQGGVKLFQEMCDKVQISDSHLKNISIRSVEGEIYCAKSGRKFAGQIREKFI 245

Query: 257 LIDCEQVVAGSYSFTWLCSQAHTSMVLQLRGRIVEDFDREFRCLYAESQPVEGFCGGEDP 316
           + D   V++GSYSFTWLC   H +++ +  G+ VE FD EFR LYA S+PV G       
Sbjct: 246 ISDWRFVLSGSYSFTWLCGHVHRNILSKFTGQAVELFDEEFRHLYASSKPVMGL------ 299

Query: 317 LSPRALRP-PPVALAFRPDVPSPTSSLPSSTSLSSIKQSPLMGRSSYLALPGGGDCSDTG 375
            SPR + P PP A      + S + S    TS      +P  GRS+       G    T 
Sbjct: 300 KSPRLVAPVPPGAAPANGRLSSSSGSASDRTS-----SNPFSGRSA-------GSHPGTR 347

Query: 376 VVSSSLGPARREAS---------------GQPSLHRQLSDPNHGSPPGLYRANLG 415
            VS+S GP    A                G PS    LS   H  PP    +NLG
Sbjct: 348 SVSASSGPCSPAAPHPPPPPRFQPHQGPWGAPSPQAHLSPRPHDGPPAAVYSNLG 402


>gi|46255017 hypothetical protein LOC84985 isoform b [Homo sapiens]
          Length = 367

 Score =  240 bits (612), Expect = 4e-63
 Identities = 138/346 (39%), Positives = 204/346 (58%), Gaps = 14/346 (4%)

Query: 17  GPLRGRVEELKLPWWRESSPLVLRHSEAARLAADALLERGEAAYLRVISEERELPFLSAL 76
           G +R R+E++K  W R +       +E+ARLA DALL+ G  AY RV+S+E E+ FLS++
Sbjct: 8   GKIRKRLEDVKSQWVRPARA-DFSDNESARLATDALLDGGSEAYWRVLSQEGEVDFLSSV 66

Query: 77  DVDYMTSHVRGGPELSEAQGQEASGPDRLSLLSEVTSGTYFPMASDIDPPDLDLGWPEVP 136
           +  Y+ +  R  P   +  G   +GP  L   S + SGTYFP+AS+   P L   W    
Sbjct: 67  EAQYIQAQAREPPCPPDTLGGAEAGPKGLDS-SSLQSGTYFPVASEGSEPALLHSWASAE 125

Query: 137 QATGFSPTQAVVHFQRDKAKNIKDLLRFLFSQAHTVVAVVMDIFTDMELLCDLMEASSRR 196
           +      + A V+FQ  K  NI+DL+R   ++   V+ ++MD+FTD+E+ CD++EA+++R
Sbjct: 126 KPYLKEKSSATVYFQTVKHNNIRDLVRRCITRTSQVLVILMDVFTDVEIFCDILEAANKR 185

Query: 197 GVPVYLLLAQEHLRHFLEMCYKMDLNGEHLPNMRVRSTCGDTYCSKAGRRFTGQALEKFV 256
           GV V +LL Q  ++ F EMC K+ ++  HL N+ +RS  G+ YC+K+GR+F GQ  EKF+
Sbjct: 186 GVFVCVLLDQGGVKLFQEMCDKVQISDSHLKNISIRSVEGEIYCAKSGRKFAGQIREKFI 245

Query: 257 LIDCEQVVAGSYSFTWLCSQAHTSMVLQLRGRIVEDFDREFRCLYAESQPVEGFCGGEDP 316
           + D   V++GSYSFTWLC   H +++ +  G+ VE FD EFR LYA S+PV G       
Sbjct: 246 ISDWRFVLSGSYSFTWLCGHVHRNILSKFTGQAVELFDEEFRHLYASSKPVMGL------ 299

Query: 317 LSPRALRP-PPVALAFRPDVPSPTSSLPSSTSLSSIKQSPLMGRSS 361
            SPR + P PP A      + S + S    TS      +P  GRS+
Sbjct: 300 KSPRLVAPVPPGAAPANGRLSSSSGSASDRTS-----SNPFSGRSA 340


>gi|61676089 hypothetical protein LOC222584 [Homo sapiens]
          Length = 1011

 Score =  195 bits (496), Expect = 1e-49
 Identities = 109/265 (41%), Positives = 163/265 (61%), Gaps = 9/265 (3%)

Query: 41  HSEAARLAADALLERGEAAYLRVISEERELPFLSALDVDYMTSHVRGGPELSEAQGQEAS 100
           + E  R+A D L+E G  AY   + +ER   FL+  +++Y+  +V+   + S A G + S
Sbjct: 24  YKEWYRVAIDILIEHGLEAYQEFLVQERVSDFLAEEEINYILKNVQKVAQ-STAHGTDDS 82

Query: 101 GPDRLSLLSEVTSGTYFPMASDIDPPDLDLGWPEV-PQATGFSPTQAVVHFQRDKAKNIK 159
             D LS      SGTY+P+ SD++ P+LDLGWP V P   G +    + H  R     IK
Sbjct: 83  CDDTLS------SGTYWPVESDVEAPNLDLGWPYVMPGLLGGTHIDLLFHPPRAHLLTIK 136

Query: 160 DLLRFLFSQAHTVVAVVMDIFTDMELLCDLMEASSRRGVPVYLLLAQEHLRHFLEMCYKM 219
           + +R +  +A  V+A+VMDIFTD+++  +++EAS+R GV VY+LL + +  HFL M  K 
Sbjct: 137 ETIRKMIKEARKVIALVMDIFTDVDIFKEIVEASTR-GVSVYILLDESNFNHFLNMTEKQ 195

Query: 220 DLNGEHLPNMRVRSTCGDTYCSKAGRRFTGQALEKFVLIDCEQVVAGSYSFTWLCSQAHT 279
             + + L N+RVR+  G  Y SK G +F G+  +KF+L+DC++V+ GSYS+ W   +AH 
Sbjct: 196 GCSVQRLRNIRVRTVKGQDYLSKTGAKFHGKMEQKFLLVDCQKVMYGSYSYMWSFEKAHL 255

Query: 280 SMVLQLRGRIVEDFDREFRCLYAES 304
           SMV  + G++VE FD EFR LYA S
Sbjct: 256 SMVQIITGQLVESFDEEFRTLYARS 280


>gi|157311635 FAM83H [Homo sapiens]
          Length = 1179

 Score =  188 bits (477), Expect = 2e-47
 Identities = 117/303 (38%), Positives = 172/303 (56%), Gaps = 12/303 (3%)

Query: 41  HSEAARLAADALLERGEAAYLRVISEERELPFLSALDVDYMTSHVRGGPELSEAQGQEAS 100
           + E  RLA DAL E G  AY R ++ E    FL   ++++++ H+R  P+    +  E S
Sbjct: 24  YKEYYRLAVDALAEGGSEAYSRFLATEGAPDFLCPEELEHVSRHLRP-PQYVTREPPEGS 82

Query: 101 GPDRLSLLSEVTSGTYFPMASDIDPPDLDLGWPEVPQATGFSPTQAVVHFQRDK--AKNI 158
               L +  + +SGTY+P+ SD   P+LDLGWP      GF  T+     Q     + +I
Sbjct: 83  ---LLDVDMDGSSGTYWPVNSDQAVPELDLGWP---LTFGFQGTEVTTLVQPPPPDSPSI 136

Query: 159 KDLLRFLFSQAHTVVAVVMDIFTDMELLCDLMEASSRRGVPVYLLLAQEHLRHFLEMCYK 218
           KD  R +   A  VVAVVMD+FTD++LL +++EA++RR VPVY+LL + + +HFL+M  K
Sbjct: 137 KDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARR-VPVYILLDEMNAQHFLDMADK 195

Query: 219 MDLNGEHLPNMRVRSTCGDTYCSKAGRRFTGQALEKFVLIDCEQVVAGSYSFTWLCSQAH 278
             +N  H+  +RVR+  G TY  + G+ F G   EKF+L+DC  V++GSYSF W   + H
Sbjct: 196 CRVNLHHVDFLRVRTVAGPTYYCRTGKSFKGHVKEKFLLVDCAVVMSGSYSFMWSFEKIH 255

Query: 279 TSMVLQLRGRIVEDFDREFRCLYAESQPVEGFCGGEDPLSPRALRPPPVA--LAFRPDVP 336
            S+    +G +V  FD EFR L+A+S+P+         +   AL P   A  L   P V 
Sbjct: 256 RSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAAALARMDAYALAPYAGAGPLVGVPGVG 315

Query: 337 SPT 339
           +PT
Sbjct: 316 APT 318


>gi|115392150 hypothetical protein LOC644815 [Homo sapiens]
          Length = 823

 Score =  177 bits (448), Expect = 4e-44
 Identities = 114/330 (34%), Positives = 184/330 (55%), Gaps = 27/330 (8%)

Query: 31  WRES-SPLVLRHSEAARLAADALLERGEAAYLRVISEERELPFLSALDVDYMTSHV---- 85
           WR S S     +SE  RLA +AL+ RG  A+  V+  E    FLS L++  +   +    
Sbjct: 16  WRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYD 75

Query: 86  ------RG-----GPELSEA-QGQEASGPDRLSLLSE-VTSGTYFPMASDIDPPDLDLGW 132
                 RG     GPE +    G+EASG D + + +E + S  Y+P  SD   P LDLGW
Sbjct: 76  PGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGW 135

Query: 133 PEVPQATGFSPTQAVVHFQRDKAKNIKDLLRFLFSQAHTVVAVVMDIFTDMELLCDLMEA 192
           P+     G +     +    D   +IK+++R + SQA  V+AVVMD+FTD+++  DL++A
Sbjct: 136 PDTIAYRGVTRASVYMQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDA 195

Query: 193 SSRRGVPVYLLLAQEHLRHFLEMCYKMDLNGEHLPNMRVRSTCGDTYCSKAGRRFTGQAL 252
             +R V VY+++ + ++++FL MC +  ++  HL N+RVRS+ G  + +++  +F G   
Sbjct: 196 GFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKNLRVRSSGGTEFFTRSATKFKGALA 255

Query: 253 EKFVLIDCEQVVAGSYSFTWLCSQAHTSMVLQLRGRIVEDFDREFRCLYAESQPV--EGF 310
           +KF+ +D ++ V GSYSFTW  ++   +++  L G++VE FDR+F+ LY  S  V  +G 
Sbjct: 256 QKFMFVDGDRAVCGSYSFTWSAARTDRNVISVLSGQVVEMFDRQFQELYLMSHSVSLKGI 315

Query: 311 CGGEDPLSPRALRPPPVAL-AFRPDVPSPT 339
              ++P       P P+ L +  P VP+ T
Sbjct: 316 PMEKEP------EPEPIVLPSVVPLVPAGT 339


>gi|116235448 hypothetical protein LOC81610 [Homo sapiens]
          Length = 615

 Score =  176 bits (446), Expect = 7e-44
 Identities = 104/271 (38%), Positives = 149/271 (54%), Gaps = 7/271 (2%)

Query: 42  SEAARLAADALLERGEAAYLRVISEERELPFLSALDVDYMTSHVRGGPELSEAQGQEASG 101
           SE+ RLA + L+  G  A+   +  ER   FL+  +V  +        E  E     A+ 
Sbjct: 59  SESRRLALEELVAGGPEAFAAFLRRERLARFLNPDEVHAILRAAERPGE--EGAAAAAAA 116

Query: 102 PDRLSLLSEVTSGTYFPMASDIDPPDLDLGWPEVPQATGFSPTQAVVHFQRDKAKN---- 157
            D      + +SGTYFP  SD++PP L+LGWP   Q      T+   HFQ   A      
Sbjct: 117 EDSFGSSHDCSSGTYFPEQSDLEPPLLELGWPAFYQGAYRGATRVETHFQPRGAGEGGPY 176

Query: 158 -IKDLLRFLFSQAHTVVAVVMDIFTDMELLCDLMEASSRRGVPVYLLLAQEHLRHFLEMC 216
             KD LR     A  V+AVVMD+FTD+++  DL E   ++GV VY+LL Q  L  FL+MC
Sbjct: 177 GCKDALRQQLRSAREVIAVVMDVFTDIDIFRDLQEICRKQGVAVYILLDQALLSQFLDMC 236

Query: 217 YKMDLNGEHLPNMRVRSTCGDTYCSKAGRRFTGQALEKFVLIDCEQVVAGSYSFTWLCSQ 276
             + ++ E    M VR+  G+ Y +++G +  G+  EKF LID  +V  GSYSFTW   +
Sbjct: 237 MDLKVHPEQEKLMTVRTITGNIYYARSGTKIIGKVHEKFTLIDGIRVATGSYSFTWTDGK 296

Query: 277 AHTSMVLQLRGRIVEDFDREFRCLYAESQPV 307
            ++S ++ L G++VE FD EFR LYA+S+P+
Sbjct: 297 LNSSNLVILSGQVVEHFDLEFRILYAQSKPI 327


>gi|153251792 hypothetical protein LOC54854 [Homo sapiens]
          Length = 478

 Score =  171 bits (433), Expect = 2e-42
 Identities = 118/329 (35%), Positives = 170/329 (51%), Gaps = 32/329 (9%)

Query: 41  HSEAARLAADALLERGEAAYLRVISEERELPFLSALDVDYMTSHVRGGPELSEAQGQEAS 100
           +SE  RLA +ALL +G  A+   +  E   PFLSA +V  + +      E      QE S
Sbjct: 27  YSEGQRLALEALLSKGAEAFQTCVQREELWPFLSADEVQGLAA----AAEDWTVAKQEPS 82

Query: 101 GPDRLSLLSEVTSGT--YFPMASDIDPPDLDLGWPEVPQATGFSPTQAVVHFQRDKAKNI 158
           G    +  ++V +G+  Y+P  S+   P L LGWP      G +  Q       +    +
Sbjct: 83  GMAEGATTTDVDAGSLSYWPGQSEQPAPVLRLGWPVDSAWKGITRAQLYTQPPGEGQPPL 142

Query: 159 KDLLRFLFSQAHTVVAVVMDIFTDMELLCDLMEASSRRGVPVYLLLAQEHLRHFLEMCYK 218
           K+L+R     AH +VAVVMD+FTD +LL DL++A++RR VPVYLLL ++ L  FLE+  +
Sbjct: 143 KELVRLEIQAAHKLVAVVMDVFTDPDLLLDLVDAATRRWVPVYLLLDRQQLPAFLELAQQ 202

Query: 219 MDLNGEHLPNMRVRSTCGDTYCSKAGRRFTGQALEKFVLIDCEQVVAGSYSFTWLCSQAH 278
           + +N  +  N+ VR   G ++ S+  R+ +G   EKFVL+D E+V++GSYSFTW  ++ H
Sbjct: 203 LGVNPWNTENVDVRVVRGCSFQSRWRRQVSGTVREKFVLLDGERVISGSYSFTWSDARLH 262

Query: 279 TSMVLQLRGRIVEDFDREFRCLYAESQP-----------VEGFCGGEDP--------LSP 319
             +V  L G IV+ F  EFR LYA S P           + G   G  P        ++P
Sbjct: 263 RGLVTLLTGEIVDAFSLEFRTLYAASCPLPPAPPQKPSVIGGLQRGRSPHRVSRRRSVAP 322

Query: 320 RALRPPPVALAFR-------PDVPSPTSS 341
            +  PP   LA R       P  P P  S
Sbjct: 323 ASPPPPDGPLAHRLAACRVSPATPGPALS 351


>gi|156564372 hypothetical protein LOC113828 [Homo sapiens]
          Length = 500

 Score =  154 bits (388), Expect = 4e-37
 Identities = 97/275 (35%), Positives = 150/275 (54%), Gaps = 9/275 (3%)

Query: 41  HSEAARLAADALLERGEAAYLRVISEERELPFLSALDVDYMT---SHVRGGPELSEAQGQ 97
           + E  R A +ALL  GE AY   + EE+   FLS+ +   +    S        + A+G+
Sbjct: 27  YCERRRAALEALLGGGEQAYRERLKEEQLRDFLSSPERQALRAAWSPYEDAVPAANARGK 86

Query: 98  EASGPDRLSLLSEVTSG---TYFPMASDIDPPDLDLGWPEVPQATGFSPTQAVVHFQRD- 153
            +    +    +   SG    Y+P  SD + P LDLGW +     G S      H  +D 
Sbjct: 87  -SKAKAKAPAPAPAESGESLAYWPDRSDTEVPPLDLGWTDTGFYRGVSRVTLFTHPPKDE 145

Query: 154 KAKNIKDLLRFLFSQAHTVVAVVMDIFTDMELLCDLMEASSRRGVPVYLLLAQEHLRHFL 213
           KA ++K ++R +  QA  V+AVVMD+FTD ++  D+++A+ +R VPVY++L +  +++FL
Sbjct: 146 KAPHLKQVVRQMIQQAQKVIAVVMDLFTDGDIFQDIVDAACKRRVPVYIILDEAGVKYFL 205

Query: 214 EMCYKMDLNGEHLPNMRVRSTCGDTYCSKAGRRFTGQALEKFVLIDCEQVVAGSYSFTWL 273
           EMC  + L    + N+RVRS  G  +    G R  G    +F+++D ++V  GSY FTW 
Sbjct: 206 EMCQDLQLTDFRIRNIRVRSVTGVGFYMPMG-RIKGTLSSRFLMVDGDKVATGSYRFTWS 264

Query: 274 CSQAHTSMVLQLRGRIVEDFDREFRCLYAESQPVE 308
            S    +++L L G+ VE FD EFR LYA S+ V+
Sbjct: 265 SSHVDRNLLLLLTGQNVEPFDTEFRELYAISEEVD 299


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 116/445 (26%), Positives = 158/445 (35%), Gaps = 79/445 (17%)

Query: 316 PLSPRALRPP--PVALAFRP--DVPSPTSSLPSSTSLSSIKQSPLMGRSSYLALPGGGDC 371
           PLSP A  PP  P ALA  P    PSP +S P S   +   Q+P       L  P     
Sbjct: 346 PLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPP 405

Query: 372 SDTGVVSSSLGPARREASGQPSLHRQLSDPNHGSPPGLYRANLGKLGAYPWSQSSPALNH 431
           S    V +   P         +     + P+  +PP         L   P   +SP ++ 
Sbjct: 406 SPP--VQAPFSPPASPPVSPSATPPSQAPPSLAAPP---------LQVPPSPPASPPMSP 454

Query: 432 NSTSP--LTLAVGSPLLPRSRPLLQFHRGAPALSRFPENGLPGSQEPSPLRGRWVPGTTL 489
           ++T P      + +P L  ++P  Q     PAL+  P   LP      P +  + P  +L
Sbjct: 455 SATPPPQAPPPLAAPPLQLAKPPPQ---APPALATPPLQALPSPPASFPGQAPFSPSASL 511

Query: 490 --ETVEEKEKKASPSQSRGQLDL--------LVPFPRAREVGDPDSGVTPNSGP-----L 534
               +     +A P  +   L +         +  PR      PD+ V   SGP     L
Sbjct: 512 PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSV---SGPRLTLAL 568

Query: 535 RPGEQAPEDRRLSPSQADSQLDLLSRALGTGGAPELGSLRPGDRALEDRRLSLNQSRGQS 594
            PG   P  R  SPS   S  DL   +      PE   LR  D   E    +       +
Sbjct: 569 APGPPPPPSR--SPSSTLSGPDLAGHSSSATSTPE--ELRGYDSGPEGGAAA--SPPPDA 622

Query: 595 DLLMQYPKA--QGSRVPLETNSSARPARRAPDERRQTLGHSQLD-LITKF---GPFRGEG 648
           +L   +P A  +G   PL    + R A  AP       G    D L T +   GP     
Sbjct: 623 ELAACHPAAWSRGPAPPL----AFRGAPGAPLPWPPATGPGSADGLCTIYETEGP-ESAT 677

Query: 649 PGPNGL-PISSPART---------AGAGSGDEKRLTLGHSKL---------DLITKYHQL 689
           P P  L P  SP  +         AGA S   K+  LG   L          L+++   L
Sbjct: 678 PAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLL 737

Query: 690 HGAR-----QGTEPGGPKGGHLNGG 709
             A       G  PGG +GG + GG
Sbjct: 738 AAAEGAAGGSGGGPGGAEGGGVTGG 762


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 83/295 (28%), Positives = 110/295 (37%), Gaps = 52/295 (17%)

Query: 309  GFCGGEDPLSPRA-------LRPPPVALAFRPDVPSPTSSLPSSTSLSSIKQSPLMGRSS 361
            G  G  DP SP A       + PPP A    P+ P P   LP S        SP+   S 
Sbjct: 962  GAKGDSDPESPLAAPILETPISPPPEANCTDPE-PVPPMILPPSPG------SPVGPASP 1014

Query: 362  YLALPGGGDCSDTGVVSSSLGPARREASGQPSLHRQLSDPNHGSPPGLY-----RANLGK 416
             L  P    CS   ++  SL P     S        LS P+  SP G        A L +
Sbjct: 1015 ILMEPLPPQCSP--LLQHSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHE 1072

Query: 417  LGAYPWSQSS-PALNHNSTSPLTLAVGSPLLPRSRPLLQFHRGAPALSRFPENGLPGSQE 475
            +     S+   PAL  ++TSPL   +G    P   P       APAL  F  +GL   ++
Sbjct: 1073 METEKVSEPECPALEPSATSPLPSPMGDLSCPAPSP-------APALDDF--SGL--GED 1121

Query: 476  PSPLRGRWVPGTTLETVEEKEKKASPSQSRGQLDLLVP-----------FPRAREVGDPD 524
             +PL G   PG+  E  +     A  S+ +G   LL P           +P  ++     
Sbjct: 1122 TAPLDGIDAPGSQPEPGQTPGSLA--SELKGSPVLLDPEELAPVTPMEVYPECKQTAGQG 1179

Query: 525  SGVTPNSGPLRPGEQAPEDRRLSPSQADSQLDLLSR----ALGTGGAPELGSLRP 575
            S       P  P   AP    L  S   +++  LS+    A   G  P LGS  P
Sbjct: 1180 SPCEEQEEPRAP--VAPTPPTLIKSDIVNEISNLSQGDASASFPGSEPLLGSPDP 1232



 Score = 34.3 bits (77), Expect = 0.43
 Identities = 68/297 (22%), Positives = 100/297 (33%), Gaps = 35/297 (11%)

Query: 313  GEDPLSPRALRPPPVALAFRPDVPSPTSSLPSSTSLSSIKQSPLMGRSSYLA---LPGGG 369
            G  PL P ++ PPP      P +    S     TS    ++ P  G  S LA   LPG  
Sbjct: 2606 GLSPLRPPSVLPPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATAELPGTQ 2665

Query: 370  DCSDTGVVSSSLGPARREASGQPSLHRQLSDPN----HGSPPGLYRANLGKLGAYPWSQS 425
            D   +G+  + L   R+    +  L RQ    N               +G  G++    S
Sbjct: 2666 DPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAEPS 2725

Query: 426  SPALNHNS--------TSPLTLAVGSPLLPRSRPLL--QFHRGAPALSRFPENGLPGSQ- 474
            SPA    S        T   +  VG P    S P+L          LSR P    P S  
Sbjct: 2726 SPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPATPSSMD 2785

Query: 475  --------------EPSPLRGRWVPGTTLETVEEKEKKASPSQSRGQLDLLVPFPRAREV 520
                          + +P  G        + + ++++  + +  R  +    P     E+
Sbjct: 2786 VNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPSTPGPEL 2845

Query: 521  GDPDSGVTPNSG--PLRPGEQAPEDRRLSPSQADSQLDLLSRALGTGGAPELGSLRP 575
            G    G +P +G     PG   P      P+Q       + + LG GG P  G   P
Sbjct: 2846 GRQALG-SPLAGISTRLPGPGEPVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQGPP 2901



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 57/250 (22%), Positives = 76/250 (30%), Gaps = 53/250 (21%)

Query: 316 PLSPRALRPPPVALAFRPDVPSPTSSLPSSTSLSSIKQSPLMGRSSYLALPGGGDCSDTG 375
           PL    L PPP          SP S  P S+  S +++SPL                   
Sbjct: 488 PLEESPLSPPPEE--------SPLSPPPESSPFSPLEESPL------------------- 520

Query: 376 VVSSSLGPARREASGQPSLHRQLSDPNHGSP--PGLYRANLGKLGAYPWSQSSPALNHNS 433
                      E+   P+L   LS P   SP  P    + L        +   P  +  S
Sbjct: 521 -------SPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLS 573

Query: 434 TSPLTLAVGSPLLPRSRPLLQFHRGAPALSRFPENGLPGSQEPSPLRGRWVPGTTLETVE 493
             P    +  P  P   P+      +     F E+ L    E SPL             E
Sbjct: 574 PPPEESPMSPP--PEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPE 631

Query: 494 EKEKKASPSQS----RGQLDLLVPFPRAREVGDPDSGVTPNSGPLRPGEQ------APED 543
           +      P +S      ++  L P P    +  P     P   PL P  +       PE 
Sbjct: 632 DSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPP-----PEESPLSPPPEESPTSPPPEA 686

Query: 544 RRLSPSQADS 553
            RLSP   DS
Sbjct: 687 SRLSPPPEDS 696



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 3/49 (6%)

Query: 314  EDPLSPRALRPPPVALAFRP--DVPS-PTSSLPSSTSLSSIKQSPLMGR 359
            + PL+PR   PPP +    P   +PS P S +P+S    S  QSPL  R
Sbjct: 2380 QPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPR 2428



 Score = 30.0 bits (66), Expect = 8.2
 Identities = 25/77 (32%), Positives = 37/77 (48%), Gaps = 7/77 (9%)

Query: 314  EDPLSPRALRPPPVALAFRPDVPSPTSSLPSSTSLSSIKQS-PLMGRSSYLALPGGGDCS 372
            E+P +P A  PP +    + D+ +  S+L    + +S   S PL+G        GGG  S
Sbjct: 1186 EEPRAPVAPTPPTL---IKSDIVNEISNLSQGDASASFPGSEPLLGSPDP---EGGGSLS 1239

Query: 373  DTGVVSSSLGPARREAS 389
                VS+ + PAR E S
Sbjct: 1240 MELGVSTDVSPARDEGS 1256


>gi|238859651 pleckstrin homology domain containing family A member
           4 isoform 1 [Homo sapiens]
          Length = 779

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 45/173 (26%), Positives = 67/173 (38%), Gaps = 32/173 (18%)

Query: 469 GLPGSQEPSPLRGRWVPGTTLETVEEKEKKASPSQSRGQLDLLVPFPRAREVGDPDSG-- 526
           GL G Q+P P      P   L+  E  E+++ P      L+L  P     + G P  G  
Sbjct: 493 GLGGPQKPPPHTEPDSPSPVLQGEESSERESLPES----LELSSPRSPETDWGRPPGGDK 548

Query: 527 --VTPNSG---PLRPGEQAPEDRRLSPSQADSQLDLLSRALGTGGAPELGSLRPGDRALE 581
              +P+ G   P      +PE R L                    +P+LG+  P  R   
Sbjct: 549 DLASPHLGLGSPRVSRASSPEGRHLP-------------------SPQLGTKAPVARPRM 589

Query: 582 DRRLSLNQSRGQSDLLMQYPKAQGSRVPLETNSSARPARRAPD-ERRQTLGHS 633
             +  L + R   +    +P+    R+ L    +  PARR PD E+R  +GHS
Sbjct: 590 SAQEQLERMRRNQECGRPFPRPTSPRL-LTLGRTLSPARRQPDVEQRPVVGHS 641


>gi|46370084 transcription factor 12 isoform b [Homo sapiens]
          Length = 682

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 67/252 (26%), Positives = 96/252 (38%), Gaps = 34/252 (13%)

Query: 315 DPLSPRALRPPPVALAFRPDVPSPTSS--LPSSTSLSSIKQSPLMGRSSYLALPGGGDCS 372
           DPL  + +R  P  L      PSP S      S S  S K    M  S++    G  + S
Sbjct: 176 DPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSS 235

Query: 373 DTGVVSSSLGPARREASGQPSLHRQLSDPNHGSPPGLYRANLGKLGAYPWSQSSPALNH- 431
           D  + SSS G               +S P  G   G   +++ +  +Y    S   L++ 
Sbjct: 236 D--LWSSSNG---------------MSQPGFGGILGTSTSHMSQSSSYGNLHSHDRLSYP 278

Query: 432 -NSTSPLTLAVGSPLLPRSRPLLQFHRGAPALSRF--PENGLPGSQEPSPLRGRWVPGTT 488
            +S SP  +    P      P+  FHRG+ + S +    +  P +   S L  R     +
Sbjct: 279 PHSVSPTDINTSLP------PMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGS 332

Query: 489 LETVEEKEKKASPSQSRGQLDLLVPFPRAREVGDPDSGVTPNSGPLRPGEQAPEDRRLSP 548
            +T +   K  +   S        P   +  VG P S +T  S   RPG QAP     SP
Sbjct: 333 SQTGDALGKALASIYSPDHTSSSFPSNPSTPVGSP-SPLTGTSQWPRPGGQAPS----SP 387

Query: 549 SQADSQLDLLSR 560
           S  +S   L SR
Sbjct: 388 SYENSLHSLQSR 399


>gi|4507391 transcription factor 12 isoform b [Homo sapiens]
          Length = 682

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 67/252 (26%), Positives = 96/252 (38%), Gaps = 34/252 (13%)

Query: 315 DPLSPRALRPPPVALAFRPDVPSPTSS--LPSSTSLSSIKQSPLMGRSSYLALPGGGDCS 372
           DPL  + +R  P  L      PSP S      S S  S K    M  S++    G  + S
Sbjct: 176 DPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSS 235

Query: 373 DTGVVSSSLGPARREASGQPSLHRQLSDPNHGSPPGLYRANLGKLGAYPWSQSSPALNH- 431
           D  + SSS G               +S P  G   G   +++ +  +Y    S   L++ 
Sbjct: 236 D--LWSSSNG---------------MSQPGFGGILGTSTSHMSQSSSYGNLHSHDRLSYP 278

Query: 432 -NSTSPLTLAVGSPLLPRSRPLLQFHRGAPALSRF--PENGLPGSQEPSPLRGRWVPGTT 488
            +S SP  +    P      P+  FHRG+ + S +    +  P +   S L  R     +
Sbjct: 279 PHSVSPTDINTSLP------PMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGS 332

Query: 489 LETVEEKEKKASPSQSRGQLDLLVPFPRAREVGDPDSGVTPNSGPLRPGEQAPEDRRLSP 548
            +T +   K  +   S        P   +  VG P S +T  S   RPG QAP     SP
Sbjct: 333 SQTGDALGKALASIYSPDHTSSSFPSNPSTPVGSP-SPLTGTSQWPRPGGQAPS----SP 387

Query: 549 SQADSQLDLLSR 560
           S  +S   L SR
Sbjct: 388 SYENSLHSLQSR 399


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 66/260 (25%), Positives = 90/260 (34%), Gaps = 27/260 (10%)

Query: 316 PLSPRALRPPPVALAFRPDVPSPTSSLPSSTSLSSIKQSPLMGRSSYLA-------LPGG 368
           P  P  L PPP  L   P  P P S+ P ST  SS++++   GRS+ LA       L   
Sbjct: 5   PPPPPPLPPPPPPLGAPP--PPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKV 62

Query: 369 GDCSDTGV--VSSSLGPARREASGQPSLHRQLSDPNHGS----------PPGLYRANLGK 416
              +D     + SS G   +E  G  +     + P  G           P G      GK
Sbjct: 63  TQINDRSAPQIESSKG-TNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGK 121

Query: 417 LGAYPWSQS-SPALNHNSTSPLTLAVGSPLLPRSRPLLQFHRGAPALSRFPENGLPGSQE 475
            G  P S++ SP L + + S   +   SP L  +       R AP     P    P    
Sbjct: 122 TGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPP 181

Query: 476 PSPLRGRWVPGTTLETVEEKEKKASPSQSRGQLDLLVPFPRAREVGDPDSGVTPNSGPLR 535
           P P     +P     +   K    SP     + +L V  P       P     P + P  
Sbjct: 182 PPPP----LPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPL 237

Query: 536 PGEQAPEDRRLSPSQADSQL 555
           P      D+ + P  A   L
Sbjct: 238 PPASVLSDKAVKPQLAPLHL 257


>gi|210032509 hypothetical protein LOC100130302 [Homo sapiens]
          Length = 887

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 63/304 (20%), Positives = 108/304 (35%), Gaps = 27/304 (8%)

Query: 324 PPPVALAFRPDVPSPTSSLPSSTSL-----SSIKQSPLMGRSSYLALPGGGDCSDTGVVS 378
           PPP     R  +PS +  + S  S       S  + P    ++  A       +     +
Sbjct: 461 PPP-----RTQLPSSSGKISSGNSFPPQQAGSPLKRPFSAAAAIAAAAAAAAAAAAAAAA 515

Query: 379 SSLGPARREASGQPSLHRQLSDPNHGSPPGLYRANLGKLGAYPWSQSSPALNHNSTSPLT 438
           ++  PA   A+               + P    A    + A P + +S A +H+    + 
Sbjct: 516 AAPAPALAAAAAPALAAAAAPALAAAAAPAPAPAAAPAVAAAPAAAASAAPSHSQKPSVP 575

Query: 439 LAVGSPLLPRSRPLLQFHRGAPALS-RFPENGLPGSQEPSPLRGRWVPGTTLETVEEKEK 497
           L   S   P ++P  +F + APA+  R    GL       P++G    G++ + V+    
Sbjct: 576 LIQASRPCPAAQPPTKFIKIAPAIQLRTGSTGLKAINVEGPVQGAQALGSSFKPVQAPGS 635

Query: 498 KASPSQSRGQLDLLVPFPRAREVGDPDSGVTPNSGPLRPGEQAPEDRRLSPSQADSQLDL 557
            A         DL       +  G P     P  G ++    AP    L+  +    L L
Sbjct: 636 GAPAPAGISGSDL-------QSSGGPLPDARP--GAVQASSPAPLQFFLNTPEGLRPLTL 686

Query: 558 LSRALGTGGAPELGSLRPGDRALEDRRLSLNQSRGQSDLLMQYPKAQGSRVPLETNSSAR 617
           L         P+  ++  G +    + +SL Q +  +      P  QGS + L T   A 
Sbjct: 687 LQ-------VPQGSAVLTGPQQQSHQLVSLQQLQQPTAAHPPQPGPQGSALGLSTQGQAF 739

Query: 618 PARR 621
           PA++
Sbjct: 740 PAQQ 743


>gi|40807452 peroxisome proliferator-activated receptor gamma,
            coactivator-related 1 [Homo sapiens]
          Length = 1664

 Score = 39.7 bits (91), Expect = 0.010
 Identities = 69/250 (27%), Positives = 93/250 (37%), Gaps = 23/250 (9%)

Query: 309  GFCGGEDPLSPRALRPPPVALAFRPDVPSPTSSLPSSTSLSSIKQSPLMGRSSYLALPGG 368
            G  G    L P  L+PP + L+  P +P P +       L S    P +  S Y  LP  
Sbjct: 884  GGLGMPPSLPPPPLQPPSLPLSMGPVLPDPFTHY---APLPSWPCYPHVSPSGYPCLP-- 938

Query: 369  GDCSDTGVVSSSLGPARREASGQPSLHRQLSDPNHGSPPGLYRANLGKLGAYPWSQSSPA 428
                   +VS + G      +  P+     + P     P       G LG  P  Q +P 
Sbjct: 939  -PPPTVPLVSGTPG----AYAVPPTCSVPWAPPPAPVSPYSSTCTYGPLGWGPGPQHAPF 993

Query: 429  LNHNSTSPLTLAVGSPLLPRSRPLLQFHRGAPALSRFPENGLPGSQEPS---PLRGRWVP 485
             +     PL  A     +P+ +      RG PA    PEN LP S  P     L G   P
Sbjct: 994  WSTVPPPPLPPASIGRAVPQPK---MESRGTPAGP--PENVLPLSMAPPLSLGLPGHGAP 1048

Query: 486  GTTLETVEEKEKKASPSQSRGQLDLLVPFPRAREVGDPDS-GVT---PNSGPLRPGEQAP 541
             T    VE K   ASP   + ++  LV  P+ + +    + GVT   P S  L+P  Q  
Sbjct: 1049 QTEPTKVEVKPVPASP-HPKHKVSALVQSPQMKALACVSAEGVTVEEPASERLKPETQET 1107

Query: 542  EDRRLSPSQA 551
              R   P  A
Sbjct: 1108 RPREKPPLPA 1117


>gi|46370082 transcription factor 12 isoform a [Homo sapiens]
          Length = 706

 Score = 39.7 bits (91), Expect = 0.010
 Identities = 66/252 (26%), Positives = 96/252 (38%), Gaps = 34/252 (13%)

Query: 315 DPLSPRALRPPPVALAFRPDVPSPTSS--LPSSTSLSSIKQSPLMGRSSYLALPGGGDCS 372
           DPL  + +R  P  L      PSP S      S S  S K    M  S++    G  + S
Sbjct: 176 DPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSS 235

Query: 373 DTGVVSSSLGPARREASGQPSLHRQLSDPNHGSPPGLYRANLGKLGAYPWSQSSPALNH- 431
           D  + SSS G               +S P  G   G   +++ +  +Y    S   L++ 
Sbjct: 236 D--LWSSSNG---------------MSQPGFGGILGTSTSHMSQSSSYGNLHSHDRLSYP 278

Query: 432 -NSTSPLTLAVGSPLLPRSRPLLQFHRGAPALSRF--PENGLPGSQEPSPLRGRWVPGTT 488
            +S SP  +    P      P+  FHRG+ + S +    +  P +   S L  R     +
Sbjct: 279 PHSVSPTDINTSLP------PMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGS 332

Query: 489 LETVEEKEKKASPSQSRGQLDLLVPFPRAREVGDPDSGVTPNSGPLRPGEQAPEDRRLSP 548
            +T +   K  +   S        P   +  VG P S +T  S   RPG QAP     SP
Sbjct: 333 SQTGDALGKALASIYSPDHTSSSFPSNPSTPVGSP-SPLTGTSQWPRPGGQAPS----SP 387

Query: 549 SQADSQLDLLSR 560
           S  +S   L +R
Sbjct: 388 SYENSLHSLKNR 399


>gi|46370080 transcription factor 12 isoform a [Homo sapiens]
          Length = 706

 Score = 39.7 bits (91), Expect = 0.010
 Identities = 66/252 (26%), Positives = 96/252 (38%), Gaps = 34/252 (13%)

Query: 315 DPLSPRALRPPPVALAFRPDVPSPTSS--LPSSTSLSSIKQSPLMGRSSYLALPGGGDCS 372
           DPL  + +R  P  L      PSP S      S S  S K    M  S++    G  + S
Sbjct: 176 DPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSS 235

Query: 373 DTGVVSSSLGPARREASGQPSLHRQLSDPNHGSPPGLYRANLGKLGAYPWSQSSPALNH- 431
           D  + SSS G               +S P  G   G   +++ +  +Y    S   L++ 
Sbjct: 236 D--LWSSSNG---------------MSQPGFGGILGTSTSHMSQSSSYGNLHSHDRLSYP 278

Query: 432 -NSTSPLTLAVGSPLLPRSRPLLQFHRGAPALSRF--PENGLPGSQEPSPLRGRWVPGTT 488
            +S SP  +    P      P+  FHRG+ + S +    +  P +   S L  R     +
Sbjct: 279 PHSVSPTDINTSLP------PMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGS 332

Query: 489 LETVEEKEKKASPSQSRGQLDLLVPFPRAREVGDPDSGVTPNSGPLRPGEQAPEDRRLSP 548
            +T +   K  +   S        P   +  VG P S +T  S   RPG QAP     SP
Sbjct: 333 SQTGDALGKALASIYSPDHTSSSFPSNPSTPVGSP-SPLTGTSQWPRPGGQAPS----SP 387

Query: 549 SQADSQLDLLSR 560
           S  +S   L +R
Sbjct: 388 SYENSLHSLKNR 399


>gi|156564386 deltex 2 isoform b [Homo sapiens]
          Length = 575

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 42/153 (27%), Positives = 56/153 (36%), Gaps = 17/153 (11%)

Query: 393 SLHRQLSDPNHGSPPGLYRANLGKLGAYPWSQSSPALNHNSTSPLTLAVGSPLLPRSRPL 452
           S H+ LS    G   G YR ++  L AYP  Q  P   H + S           P ++P 
Sbjct: 197 SCHQCLSGSRTGPVSGRYRHSMTNLPAYPVPQHPP---HRTAS--VFGTHQAFAPYNKPS 251

Query: 453 LQFHRGAPALSRFPENG-LPGSQEPSPLRGRWV---------PGTTLETVEEKEKKASPS 502
           L   R AP L+     G  P S    PL    +         PG++          + PS
Sbjct: 252 LSGARSAPRLNTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPS 311

Query: 503 QSRGQLDLLVP--FPRAREVGDPDSGVTPNSGP 533
            S G +   VP   P+   V    +G TP   P
Sbjct: 312 SSPGSVPATVPMQMPKPSRVQQALAGATPKPEP 344


>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
           sapiens]
          Length = 847

 Score = 38.9 bits (89), Expect = 0.018
 Identities = 64/256 (25%), Positives = 82/256 (32%), Gaps = 37/256 (14%)

Query: 316 PLSPRALRPPPVALAFRPDVPS---PTSSLPSSTSLSSIKQSPLMGRSSYLALPGGGDCS 372
           P +P AL   P   +  P+ P    P     SS +   I+++ L G +   +L  G D  
Sbjct: 603 PSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQ 662

Query: 373 DTGVVSSSLG------------PARREASGQPSLHRQLSDPNHGSPPGLYRANLGKLGAY 420
             G      G            P   E    P +   L  P+    P     +LG     
Sbjct: 663 PPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLG----I 718

Query: 421 PWSQSSPALNHNSTSPLTLAVGSPL-LPRSRPLLQFHRGAPALSRFPENGLPGSQEPSPL 479
           P  Q S         P    V  P    RS P      G P   R P  GL     PSPL
Sbjct: 719 PVGQRSAKSPRREEEPRGGTVSPPPGTSRSAP------GTPGTPRSPPLGLISRPRPSPL 772

Query: 480 RGRWVPGTTLETVEEKEKKASPSQSRGQLDLLVPFP-RAREVGDPDSGVTPNSGPLRPGE 538
           R R  P + +          SP           P P RA     PDS    +S P  P +
Sbjct: 773 RSRIDPWSFVSAGPRPSPLPSPQ----------PAPRRAPWTLFPDSDPFWDSPPANPFQ 822

Query: 539 QAPEDRRLSPSQADSQ 554
             P+D R       +Q
Sbjct: 823 GGPQDCRAQTKDMGAQ 838


>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
          Length = 2157

 Score = 38.5 bits (88), Expect = 0.023
 Identities = 68/259 (26%), Positives = 91/259 (35%), Gaps = 53/259 (20%)

Query: 318 SPRALRPPPVAL---AFRPDVPSPTSSLPSSTSLSSIKQSP--LMGRSSYLALPGGGDCS 372
           +P+A  PPP AL   A     P P  +      +      P  L GR          D  
Sbjct: 692 APQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPL-------DFY 744

Query: 373 DTGVVSSSLGPARREASGQPSL-----HRQLSDPNHGSPPGLYRANLGKLGAYPWSQSSP 427
             GV  S L P  R  SG  S      H        G+PP      L  +G      ++P
Sbjct: 745 PPGVHPSGLVPRERSDSGGSSSEPFDRHAPAMLRERGTPP--VDPKLAWVGDV--FTATP 800

Query: 428 ALNHNSTSPLTLAVG---------SPLLPRSRPLLQFHRGAPALSRFPENGLPGS----- 473
           A     TSPL  A           +P +P   P L  + G      FPENG PG      
Sbjct: 801 AEPRPLTSPLRQAADEDDKGMRSETPPVPPPPPYLASYPG------FPENGAPGPPISRF 854

Query: 474 --QEPSPLRGRWVPGTTLETVEEKEKKASPSQSRGQLDLLVPFPRAREVGDPDSGVTPNS 531
             +EP P    W PG+     +E  K  +P   +       P     ++  P++G  P  
Sbjct: 855 PLEEPGPRPLPWPPGS-----DEVAKIQTPPPKKEP-----PKEETAQLTGPEAGRKPAR 904

Query: 532 GPLRPGEQAPEDRRLSPSQ 550
           G    G+  P  RR S ++
Sbjct: 905 GVGSGGQGPPPPRRESRTE 923


>gi|19924099 synapsin I isoform Ia [Homo sapiens]
          Length = 705

 Score = 38.5 bits (88), Expect = 0.023
 Identities = 68/250 (27%), Positives = 88/250 (35%), Gaps = 43/250 (17%)

Query: 446 LPRSRPLLQFHRGAPALSRFPENGLPGSQEPSPLRGRWVPGTTLETVEEKEKKASPSQSR 505
           LP  R   Q   G PA  R P  G P    P P R     G  L+       +  P Q +
Sbjct: 442 LPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQR----QGPPLQ-------QRPPPQGQ 490

Query: 506 GQLDLLVPFPRAREVGDPDSGVTPNSGPLRPGEQAPEDRRLSPSQADSQLDLLSRALGTG 565
             L  L P P    +  P    +P S P +P  QA       P+Q   +    SR +  G
Sbjct: 491 QHLSGLGP-PAGSPL--PQRLPSPTSAPQQPASQA-----APPTQGQGR---QSRPVAGG 539

Query: 566 -GAPELGSLRPGDRALEDRRLSLNQSRGQSDLL-MQYPKAQGSRVPLETNSSARPARRAP 623
            GAP   + RP       R+    Q+  Q+ +     PKA G+  P        P ++ P
Sbjct: 540 PGAPP--AARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGA--PPGGQQRQGPPQKPP 595

Query: 624 DERRQTLGHSQLDLITKFGP-----FRGEGPGPNGLPISS----------PARTAGAGSG 668
                T   SQ   + + GP      R  GPGP G P             P  TA AG  
Sbjct: 596 GPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGP 655

Query: 669 DEKRLTLGHS 678
              +L    S
Sbjct: 656 PHPQLNKSQS 665


>gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sapiens]
          Length = 2365

 Score = 38.5 bits (88), Expect = 0.023
 Identities = 77/321 (23%), Positives = 106/321 (33%), Gaps = 59/321 (18%)

Query: 318  SPRALRPP---PVALAFRPDVPSPTSSLPSSTSLSSIKQSPLMGRSSYLALPGGGDCSDT 374
            +PRA  PP   P  LAF    PSP SS  S  S    +    + R  Y  L         
Sbjct: 1223 APRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVL--------- 1273

Query: 375  GVVSSSLGPARREASGQPSLHRQLSDPNHGSPPGLYRANLGKL-----------GAYPW- 422
                + L P RR A  QP    Q S       PG  RA + +L           GA+   
Sbjct: 1274 ----ADLPPPRRLAQRQPGPQAQCSSGGRTHSPG--RAEVERLFGQERRKSEAAGAFQAQ 1327

Query: 423  --------SQSSPALNHNSTSPLTLAVGSPLLPRSRPLLQFHRGAPALSRFPENGLPGSQ 474
                    SQ    L    +SP      + L  +   L +  +  P     PE    G +
Sbjct: 1328 DEGRSQQPSQGQSQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDR 1387

Query: 475  EPSPLRGRWVPGTTLETVEEKEKKASPSQSRGQLDLLVPFPRAREVGDPDSGVTPNSGPL 534
            +   L+G  +P  T     E+E +       GQ     P    +   +P           
Sbjct: 1388 Q---LQGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVWQSQEEP----------- 1433

Query: 535  RPGEQAPEDRRLSPSQADSQLDLLSRALGTGGAPELGSLRPGDRALEDRRLSLNQSRGQS 594
             PG Q P  R L  S +  +  L        G P LG+ +  + A         +S GQ 
Sbjct: 1434 -PGSQGPH-RHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQP 1491

Query: 595  DL-----LMQYPKAQGSRVPL 610
            +        + P+  G R PL
Sbjct: 1492 EAWEEKPTHELPRELGKRSPL 1512


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score = 38.5 bits (88), Expect = 0.023
 Identities = 56/200 (28%), Positives = 80/200 (40%), Gaps = 41/200 (20%)

Query: 443 SPLLPRSRPLLQFHRGAPALSRFPENGLPGSQEPSPLRGRWVPGTTLETVEEKEKKASPS 502
           SP++  SR      R     SR P + L G  +    R +       ET +EK+   SPS
Sbjct: 277 SPIINESRS-----RDRGKKSRSPVD-LRGKSKDRRSRSKERKSKRSETDKEKKPIKSPS 330

Query: 503 QSRGQLDLLVPFPRAREVGDPDSGVTPNSGPLRPGEQAPEDRRLSPSQAD----SQLDLL 558
           +                  D  SG    S   RPG ++P+ R LSP   D    S+  LL
Sbjct: 331 K------------------DASSGKENRSPSRRPG-RSPKRRSLSPKPRDKSRRSRSPLL 371

Query: 559 -----------SRALGTGGAPELGSLRPGDRALEDRRLSLNQSRGQSDLLMQYPKAQGSR 607
                      SR L  G   +  SL    R  E RRLS  ++R + D+L +  +++ + 
Sbjct: 372 NDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDAS 431

Query: 608 VPLETNSSARPARRAPDERR 627
            P+   S  R   R+P  RR
Sbjct: 432 -PINRWSPTRRRSRSPIRRR 450


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 38.1 bits (87), Expect = 0.030
 Identities = 39/117 (33%), Positives = 48/117 (41%), Gaps = 22/117 (18%)

Query: 469  GLPGSQEPSPLRGRWVPGTTLETVEEKEKKASPSQSRGQLDLLVP----------FPRAR 518
            G PG Q P P   R +PG  +  VEEKE      Q RG    LVP           P  R
Sbjct: 2736 GRPG-QPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASPGSPSVR 2794

Query: 519  EVGDPDSGVTPNSGPLRPGEQAPEDRRLSPSQ----ADSQLDLLSRALGTGGAPELG 571
             +  P+S   P  GP    E AP     +P Q    A   ++L    +  GG+PE G
Sbjct: 2795 SMSGPESS-PPIGGPC---EAAPSSSLPTPPQQPFIARRHIEL---GVTGGGSPENG 2844



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 62/243 (25%), Positives = 86/243 (35%), Gaps = 33/243 (13%)

Query: 333  PDVPSPTSSLPSSTSLSSIKQSPLMGRSSY-LALPGGG--DCSDTGVVSSSLGPARREAS 389
            P +  P  + PSS SL +  Q P + R    L + GGG  +  D  +++ +    +R   
Sbjct: 2803 PPIGGPCEAAPSS-SLPTPPQQPFIARRHIELGVTGGGSPENGDGALLAITPPAVKRRRG 2861

Query: 390  GQPSLHRQLSDPNHGSPPGLYRANLGKL-GAYPWSQSSPALNHNSTSPLTLAVGSP---- 444
              P  +R  +D   G          GK  GA P              P TL V  P    
Sbjct: 2862 RPPKKNRSPADAGRGVDEAPSSTLKGKTNGADP-----------VPGPETLIVADPVLEP 2910

Query: 445  -LLPRSRPL--LQFHRGAPALSRFPENGLPGSQEPSPLRGRWVPGTTLETVE-EKEKKAS 500
             L+P  +PL     HR  P LS   +        P   R   +PGT     +   E +  
Sbjct: 2911 QLIPGPQPLGPQPVHRPNPLLSPVEKR---RRGRPPKARDLPIPGTISSAGDGNSESRTQ 2967

Query: 501  PSQSRGQLDLLVPF---PRAREVGDPDSGVTPNSGPLRPGEQAPEDRRLSPSQADSQLDL 557
            P      L  L P    P A       +     S P R   + P++    PS   SQL +
Sbjct: 2968 PPPHPSPLTPLPPLLVCPTATVANTVTTVTISTSPPKRKRGRPPKN---PPSPRPSQLPV 3024

Query: 558  LSR 560
            L R
Sbjct: 3025 LDR 3027



 Score = 30.0 bits (66), Expect = 8.2
 Identities = 103/404 (25%), Positives = 141/404 (34%), Gaps = 58/404 (14%)

Query: 333  PDVPSPTSS-LPSSTSLSSIKQSPLMGRSSYLALPGGGDCSDTGVVSSSLGPARREASGQ 391
            P + +PTSS +P   S  +   SP++  +S LA P     +     +S L PA   +   
Sbjct: 1524 PLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQAL 1583

Query: 392  PSLHRQLSDPNHG---SPPGLYRANLGKL----GAYPWSQSS----PALNHNSTSPLTLA 440
             +    ++ P        P    A L  L    GA P   SS    P +  +ST   +LA
Sbjct: 1584 ATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLA 1643

Query: 441  VGSPLLPRSRPLL-----QFHRGAPALSRFPENGLPGSQEP-------SPLRGRWVPGTT 488
              SP+ P   P+L     Q    AP  S  P    P S +        +P  G   P  T
Sbjct: 1644 SASPV-PAPTPVLAPSSTQTMLPAPVPSPLPS---PASTQTLALAPALAPTLGGSSPSQT 1699

Query: 489  LETVEEKEKKASPSQ--SRGQLDLLVPFPRARE--VGDPDSGVT--------PNSGPLRP 536
            L       +   P+Q  S      LVP P         P  G T        P   P  P
Sbjct: 1700 LSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASP 1759

Query: 537  GEQAPEDRRLSPSQADSQLDLLSRA------LGTGGAPELGSLRPGDRALEDRRLSLNQS 590
               AP    L+ + A S   LL+ A      L     P LG       AL         S
Sbjct: 1760 VGPAPA-HTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPASTQSPAS 1818

Query: 591  RGQSDLLMQYPKAQGSR-VPLETNSSARPARRAPDERRQTLGH-SQLDLITKFGPFRGEG 648
            +  S ++     A G+  +P+   S    ++  PD      G  S     T FG     G
Sbjct: 1819 QASSLVV----SASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSPPSTATSFG-----G 1869

Query: 649  PGPNGLPISSPARTAGAGSGDEKRLTLGHSKLDLITKYHQLHGA 692
            P P   P   P       S +EKR      +L+ I +  + HGA
Sbjct: 1870 PRPRRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGA 1913


>gi|19924097 synapsin I isoform Ib [Homo sapiens]
          Length = 669

 Score = 37.7 bits (86), Expect = 0.039
 Identities = 61/217 (28%), Positives = 80/217 (36%), Gaps = 33/217 (15%)

Query: 446 LPRSRPLLQFHRGAPALSRFPENGLPGSQEPSPLRGRWVPGTTLETVEEKEKKASPSQSR 505
           LP  R   Q   G PA  R P  G P    P P R     G  L+       +  P Q +
Sbjct: 442 LPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQR----QGPPLQ-------QRPPPQGQ 490

Query: 506 GQLDLLVPFPRAREVGDPDSGVTPNSGPLRPGEQAPEDRRLSPSQADSQLDLLSRALGTG 565
             L  L P P    +  P    +P S P +P  QA       P+Q   +    SR +  G
Sbjct: 491 QHLSGLGP-PAGSPL--PQRLPSPTSAPQQPASQA-----APPTQGQGR---QSRPVAGG 539

Query: 566 -GAPELGSLRPGDRALEDRRLSLNQSRGQSDLL-MQYPKAQGSRVPLETNSSARPARRAP 623
            GAP   + RP       R+    Q+  Q+ +     PKA G+  P        P ++ P
Sbjct: 540 PGAPP--AARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGA--PPGGQQRQGPPQKPP 595

Query: 624 DERRQTLGHSQLDLITKFGP-----FRGEGPGPNGLP 655
                T   SQ   + + GP      R  GPGP G P
Sbjct: 596 GPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRP 632


>gi|208022661 hypothetical protein LOC57701 [Homo sapiens]
          Length = 1334

 Score = 37.7 bits (86), Expect = 0.039
 Identities = 92/396 (23%), Positives = 124/396 (31%), Gaps = 81/396 (20%)

Query: 324 PPPVALAFRPDVPSPTSSLPSSTSLSSIKQSPLMGRSSYLALPGGGDCSDTGVVSSSLGP 383
           PP    A  P +PSP   L       + ++SP          PGG   S     +S +  
Sbjct: 438 PPSPGEAQGPLLPSPARGLKFLKLPPTSEKSPS---------PGGPQLSPQLPRNSRIPC 488

Query: 384 ARREASGQPS--LHRQLSDPNHGSPPGLYRANLGKLGAYPWSQSSPALNHNSTSPLTLAV 441
               + G PS  L R+       SP G           Y    S+      S    TL+ 
Sbjct: 489 RNSGSDGSPSPLLARRGLGGGELSPEGAQGLPTSPSPCYTTPDSTQLRPPQSALSTTLSP 548

Query: 442 GSPLLPRSRPLLQFHRGAPALSRFPENGLPGSQEPSPLRGRWVPGTTLETVEEKEKKASP 501
           G  + P    +L        LSR    G      PSPL+    P  TLE  +  E   SP
Sbjct: 549 GPVVSPCYENILD-------LSRSTFRGPSPEPPPSPLQVPTYPQLTLEVPQAPEVLRSP 601

Query: 502 SQSRGQLDLLVPFPRAREVGDPDSGVTPNSG--PLRPGEQAPEDRRLSPSQADSQLDLLS 559
                        P +   G P       +G     PG + P +    PSQ         
Sbjct: 602 GVPPSPC-----LPESYPYGSPQEKSLDKAGSESPHPGRRTPGNSSKKPSQ--------- 647

Query: 560 RALGTGGAPELGSLRPGDRALEDRRLSLNQSRGQSDLLMQYPKAQGSRVPLETNSSARPA 619
              G+G  P      PG   L DR  +L + +             G    L +  +  PA
Sbjct: 648 ---GSGRRPG----DPGSTPLRDRLAALGKLK------------TGPEGALGSEKNGVPA 688

Query: 620 R------RAPDERRQTLG------HSQLDLITKFGPFRGE-GPGPNGLPISSPARTAGAG 666
           R      R P +  ++ G      H  L+ +   G  RG    G N L    P      G
Sbjct: 689 RPGTEKTRGPGKSGESAGDMVPSIHRPLEQLEAKGGIRGAVALGTNSLKQQEPGLMGDPG 748

Query: 667 SGDEKRLTLGHSKLDLITKYHQLHGARQGTEPGGPK 702
           +    R+   HS            GAR   EP  P+
Sbjct: 749 A----RVYSSHSM-----------GARVDLEPVSPR 769


>gi|22094135 DOT1-like, histone H3 methyltransferase [Homo sapiens]
          Length = 1537

 Score = 37.4 bits (85), Expect = 0.051
 Identities = 90/361 (24%), Positives = 128/361 (35%), Gaps = 57/361 (15%)

Query: 345  STSLSSIKQSPLMGRSSYLALPGGGDCSDT-GVVSSSLGPARREASGQPSLHRQLSDPNH 403
            +T   S KQSP   + S L     GDC  + G  S   G  +R ++G PSL   +S    
Sbjct: 1050 TTGAGSAKQSP-SSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRR 1108

Query: 404  GSP--PGLYRANLGKLGAYPWSQSSPALNHNSTSPLTLAVGSP--LLPRSRPLLQFHRGA 459
              P   GL+    G     P + +S   N N    +T A+ SP   L  S    Q H   
Sbjct: 1109 ALPSVAGLFTQPSGS----PLNLNSMVSNINQPLEIT-AISSPETSLKSSPVPYQDHDQP 1163

Query: 460  PALSRFPENGLPGSQEPSPLRGRWVPGTTLE----TVEEK------EKKASPS--QSRGQ 507
            P L +            SPL     PG+  E     +E K      E K+ P   ++ G 
Sbjct: 1164 PVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGG 1223

Query: 508  LDLLVPFPRAREVGD----------PDSGVTPNS-GPLRPGEQAPEDR------RLSPSQ 550
            L    P P    V             D G+  ++  PL+      ++        L    
Sbjct: 1224 LAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPS 1283

Query: 551  ADSQLDLLSRALGTGGAPELGSLRPGDRALED--------RRLSLNQSRGQSDLLMQYPK 602
            AD++L    R    G       L PG                LSL+     + L  + P+
Sbjct: 1284 ADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPE 1343

Query: 603  AQGSRVPLETNSSARPARRAPD--ERRQTLGHSQLDLIT--KFGPFRGEGPGPNGLPISS 658
            A G   PL     + P++R  +  +    L   QLD +   K    RG+  G  GLP+  
Sbjct: 1344 AAGLSSPL-----SFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCG 1398

Query: 659  P 659
            P
Sbjct: 1399 P 1399


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 37.4 bits (85), Expect = 0.051
 Identities = 59/241 (24%), Positives = 87/241 (36%), Gaps = 34/241 (14%)

Query: 317  LSPRALRPPPVALAFRPDVPSPTSSLP-SSTSLSSIKQSPLMGRSSYLALPGGGDCSDTG 375
            +SP+  RPP    +  PD P    S P S    S + ++ L  + S           D+ 
Sbjct: 801  VSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGS----------KDSP 850

Query: 376  VVSSSLGPARREASGQPSLHRQLS------DPNHGSPPGLYRANLGKLG-AYPWSQSSPA 428
              + S  P   + +  PS    LS       P     P +      K G A P  + +PA
Sbjct: 851  ATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPA 910

Query: 429  LNHNSTSPLTLAVGSPLLPRSRPLLQFHRGAPALSRFPENGLPGSQEPSPLRGRWVPGTT 488
            L+  S+SP   A  +P  P+  P     +GAP          P +  PSP  G   P T 
Sbjct: 911  LSMTSSSP-KKARATP-APKGIPASPSPKGAPT--------PPAATPPSPKGG---PATP 957

Query: 489  LETVEEKEKKASPSQSRGQLDLLVPFPRAREVGDPDSGVTPNSGPLRPGEQ-APEDRRLS 547
                      A+P   +G      P P+        +  +P  GP  P  + AP    ++
Sbjct: 958  SPKWAPTPPAATPPSPKG--GPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVT 1015

Query: 548  P 548
            P
Sbjct: 1016 P 1016



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 65/306 (21%), Positives = 105/306 (34%), Gaps = 39/306 (12%)

Query: 318  SPRALRPPPVALAFRPDVPSPTSSLPSSTSLSSIKQSPLMGRSSYLALPGGGDCSDTGVV 377
            +P A+ PP          P  T + P  T  SS+K SP    S    +      +  G+ 
Sbjct: 1615 TPPAVTPPSPEKGPATPAPKGTPTSPPVTP-SSLKDSPTSPASVTCKMGATVPQASKGLP 1673

Query: 378  SSSLGPARREASGQPSLHRQLSDPNHGSPPGLYRANLGKLGAYPWSQSSPALNHNSTSPL 437
            +     A +E    P+     S P   +P              P     P+  + S  PL
Sbjct: 1674 AKKGPTALKEVLVAPAPE---STPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPL 1730

Query: 438  TLAVGSPLLPRSRPLLQFHRGAPALSRFPENGLPGSQEPSPLRGRWVPGTTLETVEEKEK 497
            +    +PLLP  +   +  +G  A           S  P   +G   P          E 
Sbjct: 1731 STVAPAPLLPVQKDSSKTAKGKDA-----------SHSP---KGPLAP---------PES 1767

Query: 498  KASPSQSRGQLDLLVPFPRAREVGDPDSGVTPNSGPLRPG--EQAPEDRRLSPSQADSQL 555
            KAS   +    + ++P P +  V    S   P S PL P      P  ++  PS     L
Sbjct: 1768 KASTPLTAAAFEKVLPKPESASVSAAPS--PPVSLPLAPSPVPTLPPKQQFLPSSPGLVL 1825

Query: 556  DLLSRALGTGGAPELGSLRPGDRALEDRRLSLNQSRGQSDLLMQYPKAQGSRVPLETNSS 615
            +  S+ L      EL  L P +         ++       +L+  P  + + +P+ T S+
Sbjct: 1826 ESPSKPLAPADEDELLPLIPPE--------PISGGVPFQSVLVNMPTPKSAGIPVPTPSA 1877

Query: 616  ARPARR 621
             +P  +
Sbjct: 1878 KQPVTK 1883


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,559,104
Number of Sequences: 37866
Number of extensions: 1965415
Number of successful extensions: 6258
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 212
Number of HSP's that attempted gapping in prelim test: 5956
Number of HSP's gapped (non-prelim): 501
length of query: 747
length of database: 18,247,518
effective HSP length: 110
effective length of query: 637
effective length of database: 14,082,258
effective search space: 8970398346
effective search space used: 8970398346
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.