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Search of human proteins with 30061491
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30061491 erythrocyte membrane protein band 4.1-like 1
isoform b [Homo sapiens]
(779 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 1563 0.0
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 1539 0.0
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 694 0.0
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 620 e-177
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 580 e-165
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 578 e-165
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 578 e-165
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 525 e-149
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 484 e-136
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 322 1e-87
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 280 5e-75
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 265 2e-70
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 265 2e-70
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 265 2e-70
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 256 6e-68
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 255 1e-67
gi|117500790 FERM domain containing 3 [Homo sapiens] 254 2e-67
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 243 6e-64
gi|34916000 FERM domain containing 7 [Homo sapiens] 239 5e-63
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 225 1e-58
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 223 4e-58
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 155 1e-37
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i... 154 4e-37
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 154 4e-37
gi|161702986 ezrin [Homo sapiens] 150 3e-36
gi|21614499 ezrin [Homo sapiens] 150 3e-36
gi|4505257 moesin [Homo sapiens] 142 2e-33
gi|4506467 radixin [Homo sapiens] 142 2e-33
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 139 1e-32
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 139 1e-32
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 1563 bits (4046), Expect = 0.0
Identities = 779/779 (100%), Positives = 779/779 (100%)
Query: 1 MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVL 60
MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVL
Sbjct: 1 MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVL 60
Query: 61 FDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQ 120
FDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQ
Sbjct: 61 FDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQ 120
Query: 121 LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF 180
LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF
Sbjct: 121 LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF 180
Query: 181 APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGV 240
APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGV
Sbjct: 181 APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGV 240
Query: 241 CANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKR 300
CANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKR
Sbjct: 241 CANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKR 300
Query: 301 LWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS 360
LWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS
Sbjct: 301 LWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS 360
Query: 361 KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKEL 420
KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKEL
Sbjct: 361 KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKEL 420
Query: 421 KFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKA 480
KFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKA
Sbjct: 421 KFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKA 480
Query: 481 NERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTS 540
NERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTS
Sbjct: 481 NERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTS 540
Query: 541 SLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGG 600
SLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGG
Sbjct: 541 SLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGG 600
Query: 601 IEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQENSLKS 660
IEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQENSLKS
Sbjct: 601 IEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQENSLKS 660
Query: 661 GKGAAAMIPGPQTVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSET 720
GKGAAAMIPGPQTVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSET
Sbjct: 661 GKGAAAMIPGPQTVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSET 720
Query: 721 RIEKRIIITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES 779
RIEKRIIITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES
Sbjct: 721 RIEKRIIITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES 779
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 1539 bits (3984), Expect = 0.0
Identities = 779/819 (95%), Positives = 779/819 (95%), Gaps = 40/819 (4%)
Query: 1 MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVL 60
MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVL
Sbjct: 63 MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVL 122
Query: 61 FDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQ 120
FDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQ
Sbjct: 123 FDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQ 182
Query: 121 LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF 180
LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF
Sbjct: 183 LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF 242
Query: 181 APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGV 240
APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGV
Sbjct: 243 APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGV 302
Query: 241 CANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKR 300
CANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKR
Sbjct: 303 CANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKR 362
Query: 301 LWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS 360
LWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS
Sbjct: 363 LWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS 422
Query: 361 KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKEL 420
KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKEL
Sbjct: 423 KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKEL 482
Query: 421 K------------FLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSP 468
K FLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSP
Sbjct: 483 KPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSP 542
Query: 469 ASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE 528
ASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE
Sbjct: 543 ASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE 602
Query: 529 RKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLN 588
RKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLN
Sbjct: 603 RKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLN 662
Query: 589 KGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVS 648
KGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVS
Sbjct: 663 KGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVS 722
Query: 649 AMDNTQ----------------------------ENSLKSGKGAAAMIPGPQTVATEIRS 680
AMDNTQ ENSLKSGKGAAAMIPGPQTVATEIRS
Sbjct: 723 AMDNTQQVDGSASVGREFIATTPSITTETISTTMENSLKSGKGAAAMIPGPQTVATEIRS 782
Query: 681 LSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQAL 740
LSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQAL
Sbjct: 783 LSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQAL 842
Query: 741 ALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES 779
ALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES
Sbjct: 843 ALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES 881
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 694 bits (1791), Expect = 0.0
Identities = 409/843 (48%), Positives = 509/843 (60%), Gaps = 119/843 (14%)
Query: 15 RTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKD 74
+T KA+K+ QK+ KK K+ C+VTLLD +EY C++EKH +GQVLFD VCEHLNLLEKD
Sbjct: 198 QTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKD 257
Query: 75 YFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQL 134
YFGL F ++ QKNWLDP+KEIK+Q+R+ PW F F VKFYPPDP+QLTEDITRY+LCLQL
Sbjct: 258 YFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQL 317
Query: 135 RADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIME 194
R DI +GRLPCSFVTHALLGSY +QAELGDYD EEH +SE +FAP QT+ELEE++ E
Sbjct: 318 RQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAE 377
Query: 195 LHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRI 254
LHKT+RG++P +A+ FLENAK+LSMYGVDLHHAKDSEG+DI LGVCANGLLIY+DRLRI
Sbjct: 378 LHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRI 437
Query: 255 NRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL 314
NRFAWPKILKISYKRSNFYIK+RP E EQFESTIGFKLPNHR+AKRLWKVC+EHHTF+RL
Sbjct: 438 NRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL 497
Query: 315 VSPEPPPKG-FLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAE 373
VSPE PPK FL +GSKFRYSGRTQAQTRQAS LIDRPAP FER+SSKR +SRSLDGA
Sbjct: 498 VSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR--VSRSLDGAP 555
Query: 374 F---------SRPASVSENHDAGP---------DGDKRDE-------------DGESGGQ 402
P + E GP DGD R E +G+
Sbjct: 556 IGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKKNSL 615
Query: 403 RSEAEEGEVRTPTKIKELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERER 462
R E + VR + L+ LDK ++ +LKHQASI+ELKR E + R +WE+ R
Sbjct: 616 RVEGDNIYVRHSNLM--LEELDKAQEDILKHQASISELKRNFMESTPE--PRPNEWEKRR 671
Query: 463 RLP-SSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLK 521
P S S T E+ G +E+V E G + +
Sbjct: 672 ITPLSLQTQGSSHETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGPGEIRKVE---- 727
Query: 522 DNHLAIERKCSSITVSSTSSLEAEVDFTVIGDY--HGSAFEDFSRSLPELDRD------- 572
+ +K S+ S +SS +E + +G+Y H E R E + +
Sbjct: 728 ----PVTQKDSTSLSSESSSSSSESEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEEPRP 783
Query: 573 -------------------------------KSDSDTEGLLFSRDLNKGAPSQD-DESGG 600
+ + + + + +++GA QD E
Sbjct: 784 AAKVVEREEAVPEASPVTQAGASVITVETVIQENVGAQKIPGEKSVHEGALKQDMGEEAE 843
Query: 601 IEDSPDRGACSTPD---MPQF----EP--VKTETMTVSSLAIRKKIEPEAVLQTRVSAMD 651
E G S D +PQ EP VKTE +T+S + R +I + V +
Sbjct: 844 EEPQKVNGEVSHVDIDVLPQIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTETKT 903
Query: 652 NTQEN-SLKSGKGAAAMIPGPQTVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVT 710
T E+ + G G L + T+E++ST+TTTH+T
Sbjct: 904 ITYESPQIDGGAGG---------------------DSGTLLTAQTITSESVSTTTTTHIT 942
Query: 711 KTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPE 770
KTVKGG SETRIEKRI+ITGD D+D DQALA AI+EA+ QHPDM VT+ VV++ET+ + E
Sbjct: 943 KTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEE 1002
Query: 771 ERD 773
D
Sbjct: 1003 GED 1005
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 620 bits (1599), Expect = e-177
Identities = 316/478 (66%), Positives = 371/478 (77%), Gaps = 15/478 (3%)
Query: 8 EADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEH 67
E D LS++++ SK +SP KI KK KS C+V LLD SEY C+VEK RGQVLFD VCEH
Sbjct: 83 EDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEH 142
Query: 68 LNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITR 127
LNLLEKDYFGLT+ DA++QKNWLDP+KEIKKQ+RS W+F+F VKFYPPDPAQL+EDITR
Sbjct: 143 LNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITR 202
Query: 128 YYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRE 187
YYLCLQLR DI++GRLPCSFVT ALLGSY VQ+ELGDYD +E +Y+SE RFAPN T+E
Sbjct: 203 YYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKE 262
Query: 188 LEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLI 247
LE++++ELHK++RGMTP EAE+HFLENAKKLSMYGVDLHHAKDSEG++IMLGVCA+GLLI
Sbjct: 263 LEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLI 322
Query: 248 YRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIE 307
YRDRLRINRFAWPK+LKISYKR+NFYIKIRPGE+EQFESTIGFKLPNHR+AKRLWKVC+E
Sbjct: 323 YRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVE 382
Query: 308 HHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSR 367
HHTFFRL+ PE PPK FL +GSKFRYSGRTQAQTR+ASALIDRPAP+FERSSSKRYTMSR
Sbjct: 383 HHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSR 442
Query: 368 SLDG----AEFSRPASVSENH---DAGPDGDKRDEDGESGGQRSEAEE----GEVRTPTK 416
SLDG +++ +S+ + P+ +E E +R + EE +R K
Sbjct: 443 SLDGEVGTGQYATTKGISQTNLITTVTPEKKAEEERDEEEDKRRKGEEVTPISAIRHEGK 502
Query: 417 IKELKFLDKPEDVLLKHQA--SINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPS 472
L P H A S EL+R KE + KL + R LP PA S
Sbjct: 503 SPGLGTDSCPLSPPSTHCAPTSPTELRRRCKENDCKL--PGYEPSRAEHLPGEPALDS 558
Score = 145 bits (366), Expect = 1e-34
Identities = 142/463 (30%), Positives = 213/463 (46%), Gaps = 100/463 (21%)
Query: 361 KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDE--DGESGGQRSEAEEGEVRTPTKIK 418
K ++S SLD S++ + D ++ D DGE+ S+ EE K +
Sbjct: 670 KAASLSASLDN-------DPSDSSEEETDSERTDTAADGETTATESDQEED---AELKAQ 719
Query: 419 ELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKG--- 475
EL +K +D L+KHQ +I+ELKRT E ++ + E E+RL +SP + +
Sbjct: 720 EL---EKTQDDLMKHQTNISELKRTFLETSTDTAVTN---EWEKRLSTSPVRLAARQEDA 773
Query: 476 ------TPEKANERAG--LREGSE-----EKVKPPRP-------------RAPESDTGDE 509
PE+ + +G L +GSE E + P + E+ T
Sbjct: 774 PMIEPLVPEETKQSSGEKLMDGSEIFSLLESARKPTEFIGGVTSTSQSWVQKMETKTESS 833
Query: 510 DQDQE--------------RDTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYH 555
+ E ++TV +++ + +S + + A+ FT I
Sbjct: 834 GIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKE 893
Query: 556 GSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPS--QDDESGGIEDSPDRGACSTP 613
GSA L E +++ + + ++ A Q+++S I S +
Sbjct: 894 GSA-------LTEGAKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISE-----TLE 941
Query: 614 DMPQFEP--VKTETMTVSSLA---IRKKIEPEAVLQTRVSAMDNTQENSLKSGKGAAAMI 668
P FE VKTET++ S++ ++ +I + V T E+S +
Sbjct: 942 QKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS--------QVD 993
Query: 669 PGPQTVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIII 728
PG L P VL S T+ET ST+TTTH+TKTVKGG SETRIEKRI+I
Sbjct: 994 PGTD--------LEP----GVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVI 1041
Query: 729 TGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEE 771
TGD D+D DQALA AIKEAK QHPDM VTK VV++ET+ +PE+
Sbjct: 1042 TGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEITPED 1084
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 580 bits (1494), Expect = e-165
Identities = 357/748 (47%), Positives = 444/748 (59%), Gaps = 123/748 (16%)
Query: 37 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 96
C+V+LLD + YEC VEKH +GQ L VCEHLNLLE+DYFGL D + K WLD +KEI
Sbjct: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEI 62
Query: 97 KKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 156
KKQ+R PWNF F VKFYPPDPAQLTEDITRYYLCLQLR DI+ GRLPCSF T ALLGSY
Sbjct: 63 KKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSY 122
Query: 157 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 216
+Q+ELGDYD E H +YVS+ + APNQT+ELEE++MELHK+YR MTP +A++ FLENAK
Sbjct: 123 TIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAK 182
Query: 217 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 276
KLSMYGVDLH AKD EG+DI+LGVC++GLL+Y+D+LRINRF WPK+LKISYKRS+F+IKI
Sbjct: 183 KLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKI 242
Query: 277 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSKFRYSG 335
RPGE EQ+ESTIGFKLP++R+AK+LWKVC+EHHTFFRL S + PK FL +GSKFRYSG
Sbjct: 243 RPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSG 302
Query: 336 RTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDE 395
RTQAQTRQASALIDRPAP FER++SKR SRSLDG A+ ++ D P R
Sbjct: 303 RTQAQTRQASALIDRPAPHFERTASKR--ASRSLDG------AAAVDSADRSP----RPT 350
Query: 396 DGESGGQRSEAEEGEVRTPTKIKELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRD 455
+ Q AE G + K + V+ K Q K T+K K
Sbjct: 351 SAPAITQGQVAEGGVLDASAK----------KTVVPKAQ------KETVKAEVKK----- 389
Query: 456 RDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQER 515
E E P A P P A E + +V P ++ E D E
Sbjct: 390 ---EDE---PPEQAEPEP--------TEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGE- 434
Query: 516 DTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFE---DFSRSLPELDRD 572
++++ ++L +E + + I +H S E +F S+PE
Sbjct: 435 -NIYIRHSNLMLE--------------DLDKSQEEIKKHHASISELKKNFMESVPEPRPS 479
Query: 573 KSDSDTEGLLFSRDLN--------KGAPSQDDESGGIEDSPD--RGACSTPDMPQFEPVK 622
+ D R LN +G P ++ I D+ + + T D+P V
Sbjct: 480 EWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVP---IVH 536
Query: 623 TETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQENSLKSGKGAAAMIPGPQTVATEIRSLS 682
TET T++ A + T +NS + PG A I S +
Sbjct: 537 TETKTITYEAAQ------------------TDDNS-------GDLDPGVLLTAQTITSET 571
Query: 683 PIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALAL 742
P + T +T T KTVKGG SETRIEKRI+ITGD D+D DQ L
Sbjct: 572 P--------------SSTTTTQIT----KTVKGGISETRIEKRIVITGDADIDHDQVLVQ 613
Query: 743 AIKEAKLQHPDMLVTKAVVYRETDPSPE 770
AIKEAK QHPDM VTK VV++ET+ + E
Sbjct: 614 AIKEAKEQHPDMSVTKVVVHQETEIADE 641
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 578 bits (1491), Expect = e-165
Identities = 287/420 (68%), Positives = 334/420 (79%), Gaps = 18/420 (4%)
Query: 15 RTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKD 74
+T KA+K+ QK+ KK K+ C+VTLLD +EY C++EKH +GQVLFD VCEHLNLLEKD
Sbjct: 198 QTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKD 257
Query: 75 YFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQL 134
YFGL F ++ QKNWLDP+KEIK+Q+R+ PW F F VKFYPPDP+QLTEDITRY+LCLQL
Sbjct: 258 YFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQL 317
Query: 135 RADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIME 194
R DI +GRLPCSFVTHALLGSY +QAELGDYD EEH +SE +FAP QT+ELEE++ E
Sbjct: 318 RQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAE 377
Query: 195 LHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRI 254
LHKT+RG++P +A+ FLENAK+LSMYGVDLHHAKDSEG+DI LGVCANGLLIY+DRLRI
Sbjct: 378 LHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRI 437
Query: 255 NRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL 314
NRFAWPKILKISYKRSNFYIK+RP E EQFESTIGFKLPNHR+AKRLWKVC+EHHTF+RL
Sbjct: 438 NRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL 497
Query: 315 VSPEPPPKG-FLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAE 373
VSPE PPK FL +GSKFRYSGRTQAQTRQAS LIDRPAP FER+SSKR +SRSLDGA
Sbjct: 498 VSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR--VSRSLDGAP 555
Query: 374 F---------SRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLD 424
P + E GP + G+R EVR+PTK L+ ++
Sbjct: 556 IGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRR------EVRSPTKAPHLQLIE 609
Score = 89.4 bits (220), Expect = 1e-17
Identities = 50/103 (48%), Positives = 64/103 (62%), Gaps = 4/103 (3%)
Query: 675 ATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVT----KTVKGGFSETRIEKRIIITG 730
A EI + P + + E S + H+ KTVKGG SETRIEKRI+ITG
Sbjct: 571 AGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKTVKGGISETRIEKRIVITG 630
Query: 731 DEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERD 773
D D+D DQALA AI+EA+ QHPDM VT+ VV++ET+ + E D
Sbjct: 631 DGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED 673
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 578 bits (1491), Expect = e-165
Identities = 287/420 (68%), Positives = 334/420 (79%), Gaps = 18/420 (4%)
Query: 15 RTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKD 74
+T KA+K+ QK+ KK K+ C+VTLLD +EY C++EKH +GQVLFD VCEHLNLLEKD
Sbjct: 198 QTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKD 257
Query: 75 YFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQL 134
YFGL F ++ QKNWLDP+KEIK+Q+R+ PW F F VKFYPPDP+QLTEDITRY+LCLQL
Sbjct: 258 YFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQL 317
Query: 135 RADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIME 194
R DI +GRLPCSFVTHALLGSY +QAELGDYD EEH +SE +FAP QT+ELEE++ E
Sbjct: 318 RQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAE 377
Query: 195 LHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRI 254
LHKT+RG++P +A+ FLENAK+LSMYGVDLHHAKDSEG+DI LGVCANGLLIY+DRLRI
Sbjct: 378 LHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRI 437
Query: 255 NRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL 314
NRFAWPKILKISYKRSNFYIK+RP E EQFESTIGFKLPNHR+AKRLWKVC+EHHTF+RL
Sbjct: 438 NRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRL 497
Query: 315 VSPEPPPKG-FLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAE 373
VSPE PPK FL +GSKFRYSGRTQAQTRQAS LIDRPAP FER+SSKR +SRSLDGA
Sbjct: 498 VSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR--VSRSLDGAP 555
Query: 374 F---------SRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLD 424
P + E GP + G+R EVR+PTK L+ ++
Sbjct: 556 IGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRR------EVRSPTKAPHLQLIE 609
Score = 89.4 bits (220), Expect = 1e-17
Identities = 50/103 (48%), Positives = 64/103 (62%), Gaps = 4/103 (3%)
Query: 675 ATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVT----KTVKGGFSETRIEKRIIITG 730
A EI + P + + E S + H+ KTVKGG SETRIEKRI+ITG
Sbjct: 571 AGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKTVKGGISETRIEKRIVITG 630
Query: 731 DEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERD 773
D D+D DQALA AI+EA+ QHPDM VT+ VV++ET+ + E D
Sbjct: 631 DGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED 673
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 525 bits (1352), Expect = e-149
Identities = 278/490 (56%), Positives = 334/490 (68%), Gaps = 53/490 (10%)
Query: 37 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 96
C+V+LLD + YEC VEKH +GQ L VCEHLNLLE+DYFGL D + K WLD +KEI
Sbjct: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEI 62
Query: 97 KKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 156
KKQ+R PWNF F VKFYPPDPAQLTEDITRYYLCLQLR DI+ GRLPCSF T ALLGSY
Sbjct: 63 KKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSY 122
Query: 157 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 216
+Q+ELGDYD E H +YVS+ + APNQT+ELEE++MELHK+YR MTP +A++ FLENAK
Sbjct: 123 TIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAK 182
Query: 217 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 276
KLSMYGVDLH AKD EG+DI+LGVC++GLL+Y+D+LRINRF WPK+LKISYKRS+F+IKI
Sbjct: 183 KLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKI 242
Query: 277 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSKFRYSG 335
RPGE EQ+ESTIGFKLP++R+AK+LWKVC+EHHTFFRL S + PK FL +GSKFRYSG
Sbjct: 243 RPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSG 302
Query: 336 RTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGA-------EFSRPAS--------- 379
RTQAQTRQASALIDRPAP FER++SKR SRSLDGA RP S
Sbjct: 303 RTQAQTRQASALIDRPAPHFERTASKR--ASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
Query: 380 -------VSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKE------------- 419
S P K E + E+ E K+
Sbjct: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYIR 420
Query: 420 -----LKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERE-------RRLPSS 467
L+ LDK ++ + KH ASI+ELK+ E S R +W++ R L +
Sbjct: 421 HSNLMLEDLDKSQEEIKKHHASISELKKNFME--SVPEPRPSEWDKRLSTHSPFRTLNIN 478
Query: 468 PASPSPKGTP 477
P+ +G P
Sbjct: 479 GQIPTGEGPP 488
Score = 89.4 bits (220), Expect = 1e-17
Identities = 64/158 (40%), Positives = 84/158 (53%), Gaps = 9/158 (5%)
Query: 619 EPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNT-QENSLKSGKGAAAMIP---GPQTV 674
E +K ++S L KK E+V + R S D +S IP GP V
Sbjct: 434 EEIKKHHASISEL---KKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLV 490
Query: 675 ATEIRSLSPIIG--KDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDE 732
T+ ++S K + + T + + T +TVKGG SETRIEKRI+ITGD
Sbjct: 491 KTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIVITGDA 550
Query: 733 DVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPE 770
D+D DQ L AIKEAK QHPDM VTK VV++ET+ + E
Sbjct: 551 DIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 588
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 484 bits (1247), Expect = e-136
Identities = 264/497 (53%), Positives = 327/497 (65%), Gaps = 70/497 (14%)
Query: 12 LSERTTPSKAQ---KSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHL 68
+ E + SKA+ K+ QK +K+++ C+V+LLD + YEC VE
Sbjct: 184 VKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVE---------------- 227
Query: 69 NLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRY 128
WLD +KEIKKQ+R PWNF F VKFYPPDPAQLTEDITRY
Sbjct: 228 -------------------TWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRY 268
Query: 129 YLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL 188
YLCLQLR DI+ GRLPCSF T ALLGSY +Q+ELGDYD E H +YVS+ + APNQT+EL
Sbjct: 269 YLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKEL 328
Query: 189 EERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIY 248
EE++MELHK+YR MTP +A++ FLENAKKLSMYGVDLH AKD EG+DI+LGVC++GLL+Y
Sbjct: 329 EEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVY 388
Query: 249 RDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEH 308
+D+LRINRF WPK+LKISYKRS+F+IKIRPGE EQ+ESTIGFKLP++R+AK+LWKVC+EH
Sbjct: 389 KDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEH 448
Query: 309 HTFFRLVSPEPPPKG-FLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSR 367
HTFFRL S + PK FL +GSKFRYSGRTQAQTRQASALIDRPAP FER++SKR SR
Sbjct: 449 HTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKR--ASR 506
Query: 368 SLDGAEFSRPASVSENHDAGP--------DG------------DKRDEDGESGGQRSEAE 407
SLDGA A S + P +G K ++ + E E
Sbjct: 507 SLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE 566
Query: 408 EGEVRTPTKIKELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERE------ 461
E P + K LDK ++ + KH ASI+ELK+ E S R +W++
Sbjct: 567 PPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFME--SVPEPRPSEWDKRLSTHSP 624
Query: 462 -RRLPSSPASPSPKGTP 477
R L + P+ +G P
Sbjct: 625 FRTLNINGQIPTGEGPP 641
Score = 108 bits (269), Expect = 2e-23
Identities = 79/218 (36%), Positives = 114/218 (52%), Gaps = 25/218 (11%)
Query: 558 AFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQ 617
A++D +S E+ + + F + + PS+ D+ SP R +P
Sbjct: 578 AWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTH-SPFRTLNINGQIPT 636
Query: 618 FEP---VKTETMTVS--SLAIRKKIEPEAVLQTRVSAMDNTQENSLKSGKGAAAMIPGPQ 672
E VKT+T+T+S + A++ +I + V T E + ++ + + PG
Sbjct: 637 GEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYE-AAQTDDNSGDLDPG-- 693
Query: 673 TVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDE 732
VL + T+ET S++TTT +TKTVKGG SETRIEKRI+ITGD
Sbjct: 694 ----------------VLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDA 737
Query: 733 DVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPE 770
D+D DQ L AIKEAK QHPDM VTK VV++ET+ + E
Sbjct: 738 DIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 775
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 322 bits (824), Expect = 1e-87
Identities = 171/399 (42%), Positives = 247/399 (61%), Gaps = 11/399 (2%)
Query: 30 KKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKN- 88
+++ +C + LLD + +V KH +GQVL D+V +HL+L E+DYFGL D DS N
Sbjct: 24 RQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLAD-DSTDNP 82
Query: 89 -WLDPSKEIKKQI-RSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCS 146
WLDP+K I+KQ+ R SP++ F VKF+ DP +L E+ TRY LQ++ DI+TGRLPC
Sbjct: 83 RWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCP 142
Query: 147 FVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGE 206
T ALL S+AVQ+ELGDYD E++ Y+S+ F PNQ ++ E+ I +LH+ + G++P E
Sbjct: 143 SNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAE 202
Query: 207 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKIS 266
AE ++L A+ L +YGV+ H+A+D +IM+GV + G+LIY++R+R+N F W KI+KIS
Sbjct: 203 AEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKIS 262
Query: 267 YKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGF-- 324
+K F+I++R +E E+ +GF + N+R+ K LWK C+EHHTFFRL P PP K F
Sbjct: 263 FKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFA 322
Query: 325 --LVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSE 382
+GSKFRY GRT+ Q+ Q F RS SK ++R L E S+S+
Sbjct: 323 HYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSK--PLARKLMDWEVVSRNSISD 380
Query: 383 NHDAGPDGDKRDEDGESGGQRSE-AEEGEVRTPTKIKEL 420
+ R G + S +EG P+ + L
Sbjct: 381 DRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHL 419
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 280 bits (715), Expect = 5e-75
Identities = 156/382 (40%), Positives = 226/382 (59%), Gaps = 11/382 (2%)
Query: 13 SERTTPSKAQKSPQKI--AKKYKSAI-CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLN 69
+E+ +AQ++ I A KS I CRV+LLD ++ ++ K +GQ LFD + HL+
Sbjct: 18 AEKERLREAQRAATHIPAAGDSKSIITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLD 77
Query: 70 LLEKDYFGLTFCDADSQKNWLDPSKEIKKQIR-SSPWNFAFTVKFYPPDPAQLTEDITRY 128
L+E DYFGL F D+ +WLD +K IKKQ++ SP+ VKFY +P L E++TRY
Sbjct: 78 LIESDYFGLRFMDSAQVAHWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRY 137
Query: 129 YLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL 188
LQL+ DI++G+L C F T L +Y +QAELGDYD EH VSE RF P QT E+
Sbjct: 138 LFVLQLKQDILSGKLDCPFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEM 197
Query: 189 EERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIY 248
E I E K YRG TP +AE ++L AK L MYGVD+H K +G D LG+ G+L++
Sbjct: 198 ELAIFEKWKEYRGQTPAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVF 257
Query: 249 RDRLRINRFAWPKILKISYKRSNFYIKI--RPGEYEQFESTIGFKLPNHRSAKRLWKVCI 306
+I F WPKI ++ +K++ + + + ++ E T F+L + ++ K LWK +
Sbjct: 258 EGDTKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAV 317
Query: 307 EHHTFFRLVSP---EPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRY 363
EHH FFRL P GF+ +GS+FRYSG+T+ QT + + R + FER SKRY
Sbjct: 318 EHHAFFRLRGPVQKSSHRSGFIRLGSRFRYSGKTEYQTTKTNKA--RRSTSFERRPSKRY 375
Query: 364 TMSRSLDGAEFSRPASVSENHD 385
+ A ++P +S +++
Sbjct: 376 SRRTLQMKACATKPEELSVHNN 397
>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
1 [Homo sapiens]
Length = 518
Score = 265 bits (676), Expect = 2e-70
Identities = 142/337 (42%), Positives = 199/337 (59%), Gaps = 8/337 (2%)
Query: 37 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 96
CRV LLD +E ++ KH +GQ LFD + HL+L+E DYFGL F D+ +WLD +K I
Sbjct: 87 CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146
Query: 97 KKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 155
KKQ++ P + F VK+Y +P L E+ TRY LQLR DI++G+L C + T L +
Sbjct: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206
Query: 156 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENA 215
+QAELG+ + EH VSE RF PNQT +E I + K RG +P +AE+ +L A
Sbjct: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKA 266
Query: 216 KKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK 275
K L MYGVD+H + +G + LG+ G+LI+ +I F WPKI K+ +K+S +
Sbjct: 267 KWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLV 326
Query: 276 IRPGEYE--QFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSP---EPPPKGFLVMGSK 330
+ + + + E T F+L + R+ K LWK +EHH FFRL +P + F+ +GS+
Sbjct: 327 VVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSR 386
Query: 331 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSR 367
FR+SGRT+ Q S L R FER SKRY R
Sbjct: 387 FRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421
>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
2 [Homo sapiens]
Length = 900
Score = 265 bits (676), Expect = 2e-70
Identities = 142/337 (42%), Positives = 199/337 (59%), Gaps = 8/337 (2%)
Query: 37 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 96
CRV LLD +E ++ KH +GQ LFD + HL+L+E DYFGL F D+ +WLD +K I
Sbjct: 87 CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146
Query: 97 KKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 155
KKQ++ P + F VK+Y +P L E+ TRY LQLR DI++G+L C + T L +
Sbjct: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206
Query: 156 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENA 215
+QAELG+ + EH VSE RF PNQT +E I + K RG +P +AE+ +L A
Sbjct: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKA 266
Query: 216 KKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK 275
K L MYGVD+H + +G + LG+ G+LI+ +I F WPKI K+ +K+S +
Sbjct: 267 KWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLV 326
Query: 276 IRPGEYE--QFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSP---EPPPKGFLVMGSK 330
+ + + + E T F+L + R+ K LWK +EHH FFRL +P + F+ +GS+
Sbjct: 327 VVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSR 386
Query: 331 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSR 367
FR+SGRT+ Q S L R FER SKRY R
Sbjct: 387 FRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 265 bits (676), Expect = 2e-70
Identities = 169/504 (33%), Positives = 249/504 (49%), Gaps = 46/504 (9%)
Query: 37 CRVTLLDASEYECEVEKHG-----RGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLD 91
C V LLD S+ ++ G +G V+ D V H+NL+E DYFGL +CD Q WLD
Sbjct: 13 CEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLD 72
Query: 92 PSK---EIKKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSF 147
P+K E K+ I + P + F +KFY DP +L E+ITRY LQ++ D++ GRLPC
Sbjct: 73 PAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPV 132
Query: 148 VTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEA 207
T A LG+YA+Q+ELGDYD +H YVSE RF P+Q ELEE I +HKT G P EA
Sbjct: 133 NTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSEA 192
Query: 208 EIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISY 267
E+++L AK L MYGVDLH + LG+ G+++Y+++ ++ ++ WP+I K+ +
Sbjct: 193 ELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHF 252
Query: 268 KRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVM 327
K + F +++ + E++ F+ + + K LWK +EHHTFFR+ PE
Sbjct: 253 KETQFELRVLGKDCN--ETSFFFEARSKTACKHLWKCSVEHHTFFRM--PENESNSLSRK 308
Query: 328 GSKF-------RYSGRTQAQ-TRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPAS 379
SKF RYSGRT Q +R S + RP RS SK Y P
Sbjct: 309 LSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTY-------------PKR 355
Query: 380 VSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTK-IKELKFLDKPEDVLLKHQASIN 438
+++ A + R G+ + +P K K+ K + P+ K A
Sbjct: 356 IAQTQPAESNSISRITANMENGENEGTIKIIAPSPVKSFKKAKNENSPDTQRSKSHAPWE 415
Query: 439 ELKRTLKEPNSKLIHRDRDWERERRLP----SSPASPSPKGTPEKANERAGLREGSEEKV 494
E P S L + D + + P +P+ S + + R G + +
Sbjct: 416 E-----NGPQSGLYNSPSDRTKSPKFPYTRRRNPSCGSDNDSVQPVRRRKAHNSGEDSDL 470
Query: 495 KPPRPRAPESDT--GDEDQDQERD 516
K R +T G E ++ R+
Sbjct: 471 KQRRRSRSRCNTSSGSESENSNRE 494
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 256 bits (654), Expect = 6e-68
Identities = 148/357 (41%), Positives = 207/357 (57%), Gaps = 8/357 (2%)
Query: 16 TTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDY 75
+T + QK P + K S ++ +LD ++ EV + G+VL D VC HLNL+E DY
Sbjct: 23 STLERGQKPPPTPSGKLVSI--KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDY 80
Query: 76 FGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFA-FTVKFYPPDPAQLTEDITRYYLCLQL 134
FGL F D WLD K I KQIR F VKF+PPD QL E++TRY LQ+
Sbjct: 81 FGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQV 140
Query: 135 RADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIME 194
+ D+ GRL C+ + ALL S+ VQ+E+GD+D E ++++ ++ P Q LE++I+E
Sbjct: 141 KQDLAQGRLTCNDTSAALLISHIVQSEIGDFD-EALDREHLAKNKYIPQQDA-LEDKIVE 198
Query: 195 LHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRI 254
H + G TP E++ LE A++L MYG+ LH AKD EG I L V G+L+++ +I
Sbjct: 199 FHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKI 258
Query: 255 NRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL 314
N F W K+ K+S+KR F IK+RP ++ T+ F + + K WK+C+EHH FFRL
Sbjct: 259 NAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRL 318
Query: 315 V-SPEPPPKGFLV-MGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSL 369
P+P PK L GS FR+SGRTQ Q FER SK +++ RSL
Sbjct: 319 FEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSI-RSL 374
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 255 bits (652), Expect = 1e-67
Identities = 133/341 (39%), Positives = 196/341 (57%), Gaps = 11/341 (3%)
Query: 24 SPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDA 83
S + + ++Y C V LLD SEY C +++ +GQ LFDL+C HLNLLEKDYFG+ F D
Sbjct: 9 SSRSLEREYS---CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDP 65
Query: 84 DSQKNWLDPSKEIKKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGR 142
D Q++WL+ +K + KQ+RS P + F VKFYP DPA L E+ITRY + LQ++ D+ GR
Sbjct: 66 DKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGR 125
Query: 143 LPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKT-YRG 201
L C ALL +Y +QAE+GDYD+ +H Y S+ +F P + +LE +I E+HKT G
Sbjct: 126 LLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSG 185
Query: 202 MTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPK 261
TP +E++FL A+ L YGVD H KD G L G ++ + R++ W +
Sbjct: 186 QTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNE 245
Query: 262 ILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEP-- 319
+ K+ ++ FY+ + + E+ + + + P + K LWK IE+ F++L
Sbjct: 246 VTKLKFEGKTFYLYV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVR 303
Query: 320 --PPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERS 358
GS+FRYSGR + ++SA I R P R+
Sbjct: 304 TVSSSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRA 344
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 254 bits (649), Expect = 2e-67
Identities = 130/340 (38%), Positives = 196/340 (57%), Gaps = 9/340 (2%)
Query: 37 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 96
C + LLD SE C +++ +GQ L D +C + +LLEKDYFG+ + D + Q++WL+P+K I
Sbjct: 34 CTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSI 93
Query: 97 KKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 155
KQ+++ P + F VKFYP +P ++ E++TRY L LQ++ DI GRL CSF A LG+
Sbjct: 94 FKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGA 153
Query: 156 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKT-YRGMTPGEAEIHFLEN 214
VQAELGDYD +EH NY+SE P Q+++LE +I+E+HK RG +P AE + L
Sbjct: 154 CIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLK 213
Query: 215 AKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYI 274
A L YGVD H KDS G LG A G ++++ RI+ WP + K+ ++ FY+
Sbjct: 214 AHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYV 273
Query: 275 KIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEP----PPKGFLVMGSK 330
G ++ ++ + F + K LWK +E+ F++ GS+
Sbjct: 274 ---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSR 330
Query: 331 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLD 370
FRYSG+ + +AS+ I R P R++ + S SL+
Sbjct: 331 FRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLN 370
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 243 bits (619), Expect = 6e-64
Identities = 141/337 (41%), Positives = 193/337 (57%), Gaps = 9/337 (2%)
Query: 38 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 97
RV LLD + ++E GQVL V + LNL+E DYFG+ F + S WL+P K I
Sbjct: 47 RVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPII 106
Query: 98 KQIRSSPWNFAF--TVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 155
+QIR P N VKF+PPDP QL E+ TRY LQL+ D++ RL C+ T ALL S
Sbjct: 107 RQIRR-PKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTS 165
Query: 156 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENA 215
+ +Q+E+GDYD E ++ + P Q LE +I+E H+ + G TP E++ LE A
Sbjct: 166 HLLQSEIGDYD-ETLDREHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAESDFQVLEIA 223
Query: 216 KKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK 275
+KL MYG+ H A D EG I L V G+L+++ +IN F W K+ K+S+KR F IK
Sbjct: 224 RKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIK 283
Query: 276 IRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG---FLVMGSKFR 332
+ P + ++ T+ F L + K WK+C+E+HTFFRL+ +P PK F GS FR
Sbjct: 284 LHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLD-QPKPKAKAVFFSRGSSFR 342
Query: 333 YSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSL 369
YSGRTQ Q +ER SK +T R+L
Sbjct: 343 YSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRAL 379
>gi|34916000 FERM domain containing 7 [Homo sapiens]
Length = 714
Score = 239 bits (611), Expect = 5e-63
Identities = 131/306 (42%), Positives = 183/306 (59%), Gaps = 5/306 (1%)
Query: 38 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 97
+V LD S+ V++ G+ LF+L C HLNL EK+YFGL FC WL+ K I
Sbjct: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
Query: 98 KQIRS-SPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 156
KQ+++ F F VKF+P DP L E++TRY LQ++ D+ GRLPCS AL+ S+
Sbjct: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
Query: 157 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 216
+Q+ELGD+ EE ++++ R+ PNQ LE +IM H+ + G +P E++I L+ A+
Sbjct: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182
Query: 217 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 276
KL MYG+ H A D EG+ I L V G+L+ R +IN F W KI K+S+KR +F IK+
Sbjct: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
Query: 277 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL-VSPEPPPKGFLV-MGSKFRYS 334
+ T+ F + + + K WK C+E+H FFRL P+ PK L GS FRYS
Sbjct: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302
Query: 335 GRTQAQ 340
GRTQ Q
Sbjct: 303 GRTQRQ 308
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 225 bits (573), Expect = 1e-58
Identities = 141/422 (33%), Positives = 212/422 (50%), Gaps = 39/422 (9%)
Query: 30 KKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCD--ADSQK 87
K IC + LD +V K GQVL D+V HL + EK+YFGL D DS +
Sbjct: 24 KTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPR 83
Query: 88 NWLDPSKEIKKQIRSS-PWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCS 146
WL+ SK I+KQ++ P F V+F+ PDP L ++ TR+ LQL+ DI GRL C
Sbjct: 84 -WLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCP 142
Query: 147 FVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGE 206
+ +L SYAVQ+ GDY++ H Y+S+ F P+Q + ++ LH+ + G+ E
Sbjct: 143 LNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSE 202
Query: 207 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKIS 266
AE ++ A+ L YGV+LH +D +D+M+G+ + G+ +YR + + + W ILKIS
Sbjct: 203 AESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKIS 262
Query: 267 YKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFL- 325
+KR F+I R + E E + F + N+RS K LWK C+EHHTFF+ P K L
Sbjct: 263 FKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLS 322
Query: 326 ---VMGSK-FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVS 381
MGS+ + S Q + ++ PA RS S + ++SL SR ++
Sbjct: 323 QYWTMGSRNTKKSVNNQYCKKVIGGMVWNPA--MRRSLSVEHLETKSLP----SRSPPIT 376
Query: 382 ENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTP------TKIKELKFLDKPEDVLLKHQA 435
N RS E+R P E+ ++ + EDV ++
Sbjct: 377 PN------------------WRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKG 418
Query: 436 SI 437
S+
Sbjct: 419 SL 420
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 223 bits (569), Expect = 4e-58
Identities = 119/308 (38%), Positives = 173/308 (56%), Gaps = 8/308 (2%)
Query: 30 KKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCD--ADSQK 87
K IC + LD +V K GQVL D+V HL + EK+YFGL D DS +
Sbjct: 24 KTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPR 83
Query: 88 NWLDPSKEIKKQIRSS-PWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCS 146
WL+ SK I+KQ++ P F V+F+ PDP L ++ TR+ LQL+ DI GRL C
Sbjct: 84 -WLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCP 142
Query: 147 FVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGE 206
+ +L SYAVQ+ GDY++ H Y+S+ F P+Q + ++ LH+ + G+ E
Sbjct: 143 LNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSE 202
Query: 207 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKIS 266
AE ++ A+ L YGV+LH +D +D+M+G+ + G+ +YR + + + W ILKIS
Sbjct: 203 AESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKIS 262
Query: 267 YKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFL- 325
+KR F+I R + E E + F + N+RS K LWK C+EHHTFF+ P K L
Sbjct: 263 FKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLS 322
Query: 326 ---VMGSK 330
MGS+
Sbjct: 323 QYWTMGSR 330
>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
isoform 3 [Homo sapiens]
Length = 782
Score = 155 bits (392), Expect = 1e-37
Identities = 97/312 (31%), Positives = 152/312 (48%), Gaps = 35/312 (11%)
Query: 137 DIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELH 196
DI GRL C + +L SYAVQ+ GDY++ H Y+S+ F P+Q + ++ LH
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 197 KTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINR 256
+ + G+ EAE ++ A+ L YGV+LH +D +D+M+G+ + G+ +YR + +
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 257 FAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVS 316
+ W ILKIS+KR F+I R + E E + F + N+RS K LWK C+EHHTFF+
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
Query: 317 PEPPPKGFL----VMGSK-FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDG 371
P K L MGS+ + S Q + ++ PA RS S + ++SL
Sbjct: 182 LLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPA--MRRSLSVEHLETKSLP- 238
Query: 372 AEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTP------TKIKELKFLDK 425
SR ++ N RS E+R P E+ ++ +
Sbjct: 239 ---SRSPPITPN------------------WRSPRLRHEIRKPRHSSADNLANEMTYITE 277
Query: 426 PEDVLLKHQASI 437
EDV ++ S+
Sbjct: 278 TEDVFYTYKGSL 289
>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
Length = 737
Score = 154 bits (388), Expect = 4e-37
Identities = 75/198 (37%), Positives = 113/198 (57%), Gaps = 4/198 (2%)
Query: 137 DIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELH 196
DI GRL C + +L SYAVQ+ GDY++ H Y+S+ F P+Q + ++ LH
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 197 KTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINR 256
+ + G+ EAE ++ A+ L YGV+LH +D +D+M+G+ + G+ +YR + +
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 257 FAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVS 316
+ W ILKIS+KR F+I R + E E + F + N+RS K LWK C+EHHTFF+
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
Query: 317 PEPPPKGFL----VMGSK 330
P K L MGS+
Sbjct: 182 LLPQEKNVLSQYWTMGSR 199
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 154 bits (388), Expect = 4e-37
Identities = 89/289 (30%), Positives = 149/289 (51%), Gaps = 16/289 (5%)
Query: 36 ICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKE 95
+ R+ LL+ E + GQ + V + L L E YF L + + +Q+ W+D K
Sbjct: 24 VARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKP 83
Query: 96 IKKQIRSSPWN--FAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALL 153
+KKQ+ F V FY P +QL ++ITRY LQL+ DI+ G +PC+ L
Sbjct: 84 LKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQL 143
Query: 154 GSYAVQAELGDYDAEEHVGNYVSELRFAP-------NQTRELEERIMELHKTYRGMTPGE 206
AVQA+ GD+D E +++ + P E +++ LH+ YRG+T +
Sbjct: 144 AGLAVQADFGDFDQYES-QDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPD 202
Query: 207 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLI-YRDRLRINRFAWPKILKI 265
AE+ +++ +++ YG + + AKDS+G DI +G C G+ + +++ F W I +
Sbjct: 203 AEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANM 262
Query: 266 SYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL 314
S+ +S F + E E TI F+ + +AK +W++C+ H F+RL
Sbjct: 263 SHNKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLCVARHKFYRL 306
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 150 bits (380), Expect = 3e-36
Identities = 100/289 (34%), Positives = 147/289 (50%), Gaps = 19/289 (6%)
Query: 38 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 97
RVT +DA E E ++ + G+ LFD V + + L E YFGL + D WL K++
Sbjct: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS 66
Query: 98 KQI--RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVTHALLG 154
Q + +P F F KFYP D A+ L +DIT+ LQ++ I++ + C T LLG
Sbjct: 67 AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLG 126
Query: 155 SYAVQAELGDYDAEEHVGNYVSELRFAPNQTR--------ELEERIMELHKTYRGMTPGE 206
SYAVQA+ GDY+ E H Y+S R P + + E+RI H +RGM
Sbjct: 127 SYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDN 186
Query: 207 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFAWPKIL 263
A + +L+ A+ L MYG++ K+ +G D+ LGV A GL IY ++ F W +I
Sbjct: 187 AMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR 246
Query: 264 KISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 312
IS+ F IK + F F P R KR+ ++C+ +H +
Sbjct: 247 NISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILQLCMGNHELY 291
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 150 bits (380), Expect = 3e-36
Identities = 100/289 (34%), Positives = 147/289 (50%), Gaps = 19/289 (6%)
Query: 38 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 97
RVT +DA E E ++ + G+ LFD V + + L E YFGL + D WL K++
Sbjct: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS 66
Query: 98 KQI--RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVTHALLG 154
Q + +P F F KFYP D A+ L +DIT+ LQ++ I++ + C T LLG
Sbjct: 67 AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLG 126
Query: 155 SYAVQAELGDYDAEEHVGNYVSELRFAPNQTR--------ELEERIMELHKTYRGMTPGE 206
SYAVQA+ GDY+ E H Y+S R P + + E+RI H +RGM
Sbjct: 127 SYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDN 186
Query: 207 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFAWPKIL 263
A + +L+ A+ L MYG++ K+ +G D+ LGV A GL IY ++ F W +I
Sbjct: 187 AMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR 246
Query: 264 KISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 312
IS+ F IK + F F P R KR+ ++C+ +H +
Sbjct: 247 NISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILQLCMGNHELY 291
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 142 bits (357), Expect = 2e-33
Identities = 98/294 (33%), Positives = 149/294 (50%), Gaps = 19/294 (6%)
Query: 33 KSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDP 92
K+ RVT +DA E E ++ + G+ LFD V + + L E +FGL + D WL
Sbjct: 3 KTISVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
Query: 93 SKEIKKQI--RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVT 149
+K++ Q + SP F F KFYP D ++ L +DIT+ LQ++ I+ + C T
Sbjct: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
Query: 150 HALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHKTYRG 201
LL SYAVQ++ GD++ E H Y++ + P + E EERI H+ +RG
Sbjct: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
Query: 202 MTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFA 258
M +A + +L+ A+ L MYGV+ K+ +G ++ LGV A GL IY R+ F
Sbjct: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
Query: 259 WPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 312
W +I IS+ F IK + F F P R KR+ +C+ +H +
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNHELY 291
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 142 bits (357), Expect = 2e-33
Identities = 95/289 (32%), Positives = 149/289 (51%), Gaps = 19/289 (6%)
Query: 38 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 97
RVT +DA E E ++ + G+ LFD V + + L E +FGL + D+ WL +K++
Sbjct: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVT 66
Query: 98 KQI--RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVTHALLG 154
+Q + +P F F KF+P D ++ L ++IT+ LQ++ I+ + C T LL
Sbjct: 67 QQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLA 126
Query: 155 SYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHKTYRGMTPGE 206
SYAVQA+ GDY+ E H Y++ R P + E EERI H+ +RGM +
Sbjct: 127 SYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLRED 186
Query: 207 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFAWPKIL 263
+ + +L+ A+ L MYGV+ K+ +G ++ LGV A GL IY ++ F W +I
Sbjct: 187 SMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIR 246
Query: 264 KISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 312
IS+ F IK + F F P R KR+ +C+ +H +
Sbjct: 247 NISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNHELY 291
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 139 bits (350), Expect = 1e-32
Identities = 97/298 (32%), Positives = 151/298 (50%), Gaps = 22/298 (7%)
Query: 30 KKYKSAICRVTLLDAS-EYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKN 88
K+ K+ R+ +DA E+ CE++ +G+ LFDLVC L L E +FGL + D+
Sbjct: 17 KQPKTFTVRIVTMDAEMEFNCEMK--WKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVA- 73
Query: 89 WLDPSKEIKKQ--IRSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPC 145
WL K++ + P F F KFYP + + L ++IT++ LQ++ I+ ++ C
Sbjct: 74 WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 133
Query: 146 SFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHK 197
LL SYAVQA+ GDYD H ++++ P + L EERI +
Sbjct: 134 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYA 193
Query: 198 TYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN-- 255
+RG EAE+ +L+ A+ L MYGV+ ++ +G +++LGV A GL IY R+
Sbjct: 194 EHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPK 253
Query: 256 -RFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 312
F W +I ISY F IK + + F+ F R K + ++CI +H F
Sbjct: 254 ISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 307
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 139 bits (350), Expect = 1e-32
Identities = 97/298 (32%), Positives = 151/298 (50%), Gaps = 22/298 (7%)
Query: 30 KKYKSAICRVTLLDAS-EYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKN 88
K+ K+ R+ +DA E+ CE++ +G+ LFDLVC L L E +FGL + D+
Sbjct: 17 KQPKTFTVRIVTMDAEMEFNCEMK--WKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVA- 73
Query: 89 WLDPSKEIKKQ--IRSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPC 145
WL K++ + P F F KFYP + + L ++IT++ LQ++ I+ ++ C
Sbjct: 74 WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 133
Query: 146 SFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHK 197
LL SYAVQA+ GDYD H ++++ P + L EERI +
Sbjct: 134 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYA 193
Query: 198 TYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN-- 255
+RG EAE+ +L+ A+ L MYGV+ ++ +G +++LGV A GL IY R+
Sbjct: 194 EHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPK 253
Query: 256 -RFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 312
F W +I ISY F IK + + F+ F R K + ++CI +H F
Sbjct: 254 ISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 307
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,503,770
Number of Sequences: 37866
Number of extensions: 1620294
Number of successful extensions: 7164
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 193
Number of HSP's that attempted gapping in prelim test: 6669
Number of HSP's gapped (non-prelim): 540
length of query: 779
length of database: 18,247,518
effective HSP length: 110
effective length of query: 669
effective length of database: 14,082,258
effective search space: 9421030602
effective search space used: 9421030602
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.