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Search of human proteins with 30061489
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30061489 erythrocyte membrane protein band 4.1-like 1
isoform a [Homo sapiens]
(881 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 1766 0.0
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 1539 0.0
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 707 0.0
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 634 0.0
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 582 e-166
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 582 e-166
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 531 e-151
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 526 e-149
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 496 e-140
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 322 1e-87
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 282 1e-75
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 265 2e-70
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 265 2e-70
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 262 9e-70
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 256 6e-68
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 255 1e-67
gi|117500790 FERM domain containing 3 [Homo sapiens] 254 2e-67
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 243 7e-64
gi|34916000 FERM domain containing 7 [Homo sapiens] 240 4e-63
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 224 2e-58
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 223 5e-58
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 155 2e-37
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i... 154 5e-37
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 154 5e-37
gi|161702986 ezrin [Homo sapiens] 153 8e-37
gi|21614499 ezrin [Homo sapiens] 153 8e-37
gi|4505257 moesin [Homo sapiens] 146 7e-35
gi|4506467 radixin [Homo sapiens] 143 8e-34
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 139 1e-32
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 139 1e-32
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 1766 bits (4574), Expect = 0.0
Identities = 881/881 (100%), Positives = 881/881 (100%)
Query: 1 MTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQS 60
MTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQS
Sbjct: 1 MTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQS 60
Query: 61 LDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQ 120
LDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQ
Sbjct: 61 LDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQ 120
Query: 121 VLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDP 180
VLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDP
Sbjct: 121 VLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDP 180
Query: 181 AQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSEL 240
AQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSEL
Sbjct: 181 AQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSEL 240
Query: 241 RFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIML 300
RFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIML
Sbjct: 241 RFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIML 300
Query: 301 GVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSA 360
GVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSA
Sbjct: 301 GVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSA 360
Query: 361 KRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERS 420
KRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERS
Sbjct: 361 KRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERS 420
Query: 421 SSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIK 480
SSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIK
Sbjct: 421 SSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIK 480
Query: 481 ELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPS 540
ELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPS
Sbjct: 481 ELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPS 540
Query: 541 SPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLA 600
SPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLA
Sbjct: 541 SPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLA 600
Query: 601 IERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRD 660
IERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRD
Sbjct: 601 IERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRD 660
Query: 661 LNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTR 720
LNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTR
Sbjct: 661 LNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTR 720
Query: 721 VSAMDNTQQVDGSASVGREFIATTPSITTETISTTMENSLKSGKGAAAMIPGPQTVATEI 780
VSAMDNTQQVDGSASVGREFIATTPSITTETISTTMENSLKSGKGAAAMIPGPQTVATEI
Sbjct: 721 VSAMDNTQQVDGSASVGREFIATTPSITTETISTTMENSLKSGKGAAAMIPGPQTVATEI 780
Query: 781 RSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQ 840
RSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQ
Sbjct: 781 RSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQ 840
Query: 841 ALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES 881
ALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES
Sbjct: 841 ALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES 881
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 1539 bits (3984), Expect = 0.0
Identities = 779/819 (95%), Positives = 779/819 (95%), Gaps = 40/819 (4%)
Query: 63 MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVL 122
MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVL
Sbjct: 1 MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVL 60
Query: 123 FDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQ 182
FDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQ
Sbjct: 61 FDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQ 120
Query: 183 LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF 242
LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF
Sbjct: 121 LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF 180
Query: 243 APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGV 302
APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGV
Sbjct: 181 APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGV 240
Query: 303 CANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKR 362
CANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKR
Sbjct: 241 CANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKR 300
Query: 363 LWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS 422
LWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS
Sbjct: 301 LWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS 360
Query: 423 KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKEL 482
KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKEL
Sbjct: 361 KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKEL 420
Query: 483 KPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSP 542
K FLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSP
Sbjct: 421 K------------FLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSP 468
Query: 543 ASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE 602
ASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE
Sbjct: 469 ASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE 528
Query: 603 RKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLN 662
RKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLN
Sbjct: 529 RKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLN 588
Query: 663 KGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVS 722
KGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVS
Sbjct: 589 KGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVS 648
Query: 723 AMDNTQQVDGSASVGREFIATTPSITTETISTTMENSLKSGKGAAAMIPGPQTVATEIRS 782
AMDNTQ ENSLKSGKGAAAMIPGPQTVATEIRS
Sbjct: 649 AMDNTQ----------------------------ENSLKSGKGAAAMIPGPQTVATEIRS 680
Query: 783 LSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQAL 842
LSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQAL
Sbjct: 681 LSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQAL 740
Query: 843 ALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES 881
ALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES
Sbjct: 741 ALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES 779
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 707 bits (1825), Expect = 0.0
Identities = 422/881 (47%), Positives = 537/881 (60%), Gaps = 76/881 (8%)
Query: 40 PEANSNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPS------KAQKSPQKIAKK 93
P + E P++ ++ E+ + ++D E G ++R T KA+K+ QK+ KK
Sbjct: 156 PSVSKVEMQPTELVSKEREEKVKETQEDKLEG-GAAKRETKEVQTNELKAEKASQKVTKK 214
Query: 94 YKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLD 153
K+ C+VTLLD +EY C++EKH +GQVLFD VCEHLNLLEKDYFGL F ++ QKNWLD
Sbjct: 215 TKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLD 274
Query: 154 PSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHA 213
P+KEIK+Q+R+ PW F F VKFYPPDP+QLTEDITRY+LCLQLR DI +GRLPCSFVTHA
Sbjct: 275 PAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHA 334
Query: 214 LLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHF 273
LLGSY +QAELGDYD EEH +SE +FAP QT+ELEE++ ELHKT+RG++P +A+ F
Sbjct: 335 LLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQF 394
Query: 274 LENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSN 333
LENAK+LSMYGVDLHHAKDSEG+DI LGVCANGLLIY+DRLRINRFAWPKILKISYKRSN
Sbjct: 395 LENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSN 454
Query: 334 FYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSK 392
FYIK+RP E EQFESTIGFKLPNHR+AKRLWKVC+EHHTF+RLVSPE PPK FL +GSK
Sbjct: 455 FYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSK 514
Query: 393 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEF---------SRPASVS 443
FRYSGRTQAQTRQAS LIDRPAP FER+SSKR +SRSLDGA P +
Sbjct: 515 FRYSGRTQAQTRQASTLIDRPAPHFERTSSKR--VSRSLDGAPIGVMDQSLMKDFPGAAG 572
Query: 444 ENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELK-----------PEQETTPRH 492
E GP + G+R EVR+PTK L+ RH
Sbjct: 573 EISAYGPGLVSIAVVQDGDGRR------EVRSPTKAPHLQLIEGKKNSLRVEGDNIYVRH 626
Query: 493 KQ---EFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLP-SSPASPSPK 548
E LDK ++ +LKHQASI+ELKR E + R +WE+ R P S S
Sbjct: 627 SNLMLEELDKAQEDILKHQASISELKRNFMESTPE--PRPNEWEKRRITPLSLQTQGSSH 684
Query: 549 GTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSI 608
T E+ G +E+V E G + + + +K S+
Sbjct: 685 ETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGPGEIRKVE--------PVTQKDSTS 736
Query: 609 TVSSTSSLEAEVDFTVIGDY--HGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAP 666
S +SS +E + +G+Y H E R E + + + + A
Sbjct: 737 LSSESSSSSSESEEEDVGEYRPHHRVTEGTIREEQEYEEEVEE----------EPRPAAK 786
Query: 667 SQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTR-VSAMD 725
+ E E SP A ++ + E V E + + K + A+ Q A +
Sbjct: 787 VVEREEAVPEASPVTQAGAS--VITVETVIQENVGAQKIPGEKSVHEGALKQDMGEEAEE 844
Query: 726 NTQQVDGSAS-----VGREFIATTPSITTETISTTMENSLKSGKGAAAMIPGPQTVATEI 780
Q+V+G S V + I + +T T+ ++ + + + +P QT I
Sbjct: 845 EPQKVNGEVSHVDIDVLPQIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTETKTI 904
Query: 781 RSLSPII----GKD--VLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDE 834
SP I G D L + T+E++ST+TTTH+TKTVKGG SETRIEKRI+ITGD
Sbjct: 905 TYESPQIDGGAGGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVITGDG 964
Query: 835 DVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERD 875
D+D DQALA AI+EA+ QHPDM VT+ VV++ET+ + E D
Sbjct: 965 DIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED 1005
Score = 31.2 bits (69), Expect = 4.4
Identities = 36/131 (27%), Positives = 52/131 (39%), Gaps = 16/131 (12%)
Query: 1 MTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQS 60
MTTE G SEVKK Q A P A + +++ E+ Q AE
Sbjct: 1 MTTEVGSVSEVKKDS----SQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQ 56
Query: 61 LDM----EEKDYSEADGLSERTTP-SKAQKSPQKIA-------KKYKSAICRVTLLDASE 108
+ EK+ SE+ G+S P K QKS + K+ A+ +LD E
Sbjct: 57 SSLRRQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEE 116
Query: 109 YECEVEKHGRG 119
E ++ +G
Sbjct: 117 PLPEEQRQAKG 127
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 634 bits (1635), Expect = 0.0
Identities = 338/570 (59%), Positives = 400/570 (70%), Gaps = 36/570 (6%)
Query: 1 MTTETGPDSEVKKAQEEAPQQPEAA---AAVTTPVTP--------------AGHGHPEAN 43
MTTE+G DSE K QE PQ+ A A P P A H P
Sbjct: 1 MTTESGSDSESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRR 60
Query: 44 SNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTL 103
+ R A+Q E E D LS++++ SK +SP KI KK KS C+V L
Sbjct: 61 EVTDKEQEFAARAAKQL----EYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVIL 116
Query: 104 LDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIR 163
LD SEY C+VEK RGQVLFD VCEHLNLLEKDYFGLT+ DA++QKNWLDP+KEIKKQ+R
Sbjct: 117 LDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVR 176
Query: 164 SSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAE 223
S W+F+F VKFYPPDPAQL+EDITRYYLCLQLR DI++GRLPCSFVT ALLGSY VQ+E
Sbjct: 177 SGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSE 236
Query: 224 LGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMY 283
LGDYD +E +Y+SE RFAPN T+ELE++++ELHK++RGMTP EAE+HFLENAKKLSMY
Sbjct: 237 LGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMY 296
Query: 284 GVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEY 343
GVDLHHAKDSEG++IMLGVCA+GLLIYRDRLRINRFAWPK+LKISYKR+NFYIKIRPGE+
Sbjct: 297 GVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEF 356
Query: 344 EQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQT 403
EQFESTIGFKLPNHR+AKRLWKVC+EHHTFFRL+ PE PPK FL +GSKFRYSGRTQAQT
Sbjct: 357 EQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQT 416
Query: 404 RQASALIDRPAPFFERSSSKRYTMSRSLDG----AEFSRPASVSENH---DAGPDGDKRD 456
R+ASALIDRPAP+FERSSSKRYTMSRSLDG +++ +S+ + P+ +
Sbjct: 417 RRASALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYATTKGISQTNLITTVTPEKKAEE 476
Query: 457 EDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKR 516
E E +R + EE T I ++ E ++ P S EL+R
Sbjct: 477 ERDEEEDKRRKGEE-----VTPISAIRHEGKSPGLGTDSCPLSPPSTHCA-PTSPTELRR 530
Query: 517 TLKEPNSKLIHRDRDWERERRLPSSPASPS 546
KE + KL + R LP PA S
Sbjct: 531 RCKENDCKL--PGYEPSRAEHLPGEPALDS 558
Score = 146 bits (368), Expect = 9e-35
Identities = 137/438 (31%), Positives = 209/438 (47%), Gaps = 53/438 (12%)
Query: 456 DEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELK 515
++ +S + +++E + + + +QE K + L+K +D L+KHQ +I+ELK
Sbjct: 680 NDPSDSSEEETDSERTDTAADGETTATESDQEEDAELKAQELEKTQDDLMKHQTNISELK 739
Query: 516 RTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRA 575
RT E ++ + E E+RL +SP R R+ ++P P
Sbjct: 740 RTFLETSTDTAVTN---EWEKRLSTSPV-------------RLAARQEDAPMIEPLVPEE 783
Query: 576 PESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAEVD-FTVIGDYHGSAFE 634
+ +G++ D L+ RK + TS+ ++ V + G E
Sbjct: 784 TKQSSGEKLMDGSEIFSLLES-----ARKPTEFIGGVTSTSQSWVQKMETKTESSGIETE 838
Query: 635 DFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEP 694
LP L +K +T + R ++ + D S DS D A P F
Sbjct: 839 PTVHHLP-LSTEKVVQETVLVEERRVVH----ASGDASYSAGDSGDAAA-----QPAFTG 888
Query: 695 VKTETMTVSSLAIRKKIEPE---AVL-QTRVSAMDNTQQVDGSASVG-REFIATTP---- 745
+K + + + +++ E AVL Q +A +Q + SA++ E + P
Sbjct: 889 IKGKEGSALTEGAKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFES 948
Query: 746 -SITTETIS--TTMENSLK---SGKGAAAMIPGPQTVATEIRSLSPIIGKD----VLTST 795
++ TETIS + +K S K + +T+ E + P G D VL S
Sbjct: 949 STVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESSQVDP--GTDLEPGVLMSA 1006
Query: 796 YGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPD 855
T+ET ST+TTTH+TKTVKGG SETRIEKRI+ITGD D+D DQALA AIKEAK QHPD
Sbjct: 1007 QTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPD 1066
Query: 856 MLVTKAVVYRETDPSPEE 873
M VTK VV++ET+ +PE+
Sbjct: 1067 MSVTKVVVHKETEITPED 1084
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 582 bits (1499), Expect = e-166
Identities = 295/460 (64%), Positives = 350/460 (76%), Gaps = 25/460 (5%)
Query: 40 PEANSNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPS------KAQKSPQKIAKK 93
P + E P++ ++ E+ + ++D E G ++R T KA+K+ QK+ KK
Sbjct: 156 PSVSKVEMQPTELVSKEREEKVKETQEDKLEG-GAAKRETKEVQTNELKAEKASQKVTKK 214
Query: 94 YKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLD 153
K+ C+VTLLD +EY C++EKH +GQVLFD VCEHLNLLEKDYFGL F ++ QKNWLD
Sbjct: 215 TKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLD 274
Query: 154 PSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHA 213
P+KEIK+Q+R+ PW F F VKFYPPDP+QLTEDITRY+LCLQLR DI +GRLPCSFVTHA
Sbjct: 275 PAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHA 334
Query: 214 LLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHF 273
LLGSY +QAELGDYD EEH +SE +FAP QT+ELEE++ ELHKT+RG++P +A+ F
Sbjct: 335 LLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQF 394
Query: 274 LENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSN 333
LENAK+LSMYGVDLHHAKDSEG+DI LGVCANGLLIY+DRLRINRFAWPKILKISYKRSN
Sbjct: 395 LENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSN 454
Query: 334 FYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSK 392
FYIK+RP E EQFESTIGFKLPNHR+AKRLWKVC+EHHTF+RLVSPE PPK FL +GSK
Sbjct: 455 FYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSK 514
Query: 393 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEF---------SRPASVS 443
FRYSGRTQAQTRQAS LIDRPAP FER+SSKR +SRSLDGA P +
Sbjct: 515 FRYSGRTQAQTRQASTLIDRPAPHFERTSSKR--VSRSLDGAPIGVMDQSLMKDFPGAAG 572
Query: 444 ENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELK 483
E GP + G+R EVR+PTK L+
Sbjct: 573 EISAYGPGLVSIAVVQDGDGRR------EVRSPTKAPHLQ 606
Score = 89.4 bits (220), Expect = 1e-17
Identities = 50/103 (48%), Positives = 64/103 (62%), Gaps = 4/103 (3%)
Query: 777 ATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVT----KTVKGGFSETRIEKRIIITG 832
A EI + P + + E S + H+ KTVKGG SETRIEKRI+ITG
Sbjct: 571 AGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKTVKGGISETRIEKRIVITG 630
Query: 833 DEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERD 875
D D+D DQALA AI+EA+ QHPDM VT+ VV++ET+ + E D
Sbjct: 631 DGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED 673
Score = 31.2 bits (69), Expect = 4.4
Identities = 36/131 (27%), Positives = 52/131 (39%), Gaps = 16/131 (12%)
Query: 1 MTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQS 60
MTTE G SEVKK Q A P A + +++ E+ Q AE
Sbjct: 1 MTTEVGSVSEVKKDS----SQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQ 56
Query: 61 LDM----EEKDYSEADGLSERTTP-SKAQKSPQKIA-------KKYKSAICRVTLLDASE 108
+ EK+ SE+ G+S P K QKS + K+ A+ +LD E
Sbjct: 57 SSLRRQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEE 116
Query: 109 YECEVEKHGRG 119
E ++ +G
Sbjct: 117 PLPEEQRQAKG 127
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 582 bits (1499), Expect = e-166
Identities = 295/460 (64%), Positives = 350/460 (76%), Gaps = 25/460 (5%)
Query: 40 PEANSNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPS------KAQKSPQKIAKK 93
P + E P++ ++ E+ + ++D E G ++R T KA+K+ QK+ KK
Sbjct: 156 PSVSKVEMQPTELVSKEREEKVKETQEDKLEG-GAAKRETKEVQTNELKAEKASQKVTKK 214
Query: 94 YKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLD 153
K+ C+VTLLD +EY C++EKH +GQVLFD VCEHLNLLEKDYFGL F ++ QKNWLD
Sbjct: 215 TKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLD 274
Query: 154 PSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHA 213
P+KEIK+Q+R+ PW F F VKFYPPDP+QLTEDITRY+LCLQLR DI +GRLPCSFVTHA
Sbjct: 275 PAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHA 334
Query: 214 LLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHF 273
LLGSY +QAELGDYD EEH +SE +FAP QT+ELEE++ ELHKT+RG++P +A+ F
Sbjct: 335 LLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQF 394
Query: 274 LENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSN 333
LENAK+LSMYGVDLHHAKDSEG+DI LGVCANGLLIY+DRLRINRFAWPKILKISYKRSN
Sbjct: 395 LENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSN 454
Query: 334 FYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSK 392
FYIK+RP E EQFESTIGFKLPNHR+AKRLWKVC+EHHTF+RLVSPE PPK FL +GSK
Sbjct: 455 FYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSK 514
Query: 393 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEF---------SRPASVS 443
FRYSGRTQAQTRQAS LIDRPAP FER+SSKR +SRSLDGA P +
Sbjct: 515 FRYSGRTQAQTRQASTLIDRPAPHFERTSSKR--VSRSLDGAPIGVMDQSLMKDFPGAAG 572
Query: 444 ENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELK 483
E GP + G+R EVR+PTK L+
Sbjct: 573 EISAYGPGLVSIAVVQDGDGRR------EVRSPTKAPHLQ 606
Score = 89.4 bits (220), Expect = 1e-17
Identities = 50/103 (48%), Positives = 64/103 (62%), Gaps = 4/103 (3%)
Query: 777 ATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVT----KTVKGGFSETRIEKRIIITG 832
A EI + P + + E S + H+ KTVKGG SETRIEKRI+ITG
Sbjct: 571 AGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKTVKGGISETRIEKRIVITG 630
Query: 833 DEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERD 875
D D+D DQALA AI+EA+ QHPDM VT+ VV++ET+ + E D
Sbjct: 631 DGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED 673
Score = 31.2 bits (69), Expect = 4.4
Identities = 36/131 (27%), Positives = 52/131 (39%), Gaps = 16/131 (12%)
Query: 1 MTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQS 60
MTTE G SEVKK Q A P A + +++ E+ Q AE
Sbjct: 1 MTTEVGSVSEVKKDS----SQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQ 56
Query: 61 LDM----EEKDYSEADGLSERTTP-SKAQKSPQKIA-------KKYKSAICRVTLLDASE 108
+ EK+ SE+ G+S P K QKS + K+ A+ +LD E
Sbjct: 57 SSLRRQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEE 116
Query: 109 YECEVEKHGRG 119
E ++ +G
Sbjct: 117 PLPEEQRQAKG 127
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 531 bits (1369), Expect = e-151
Identities = 283/491 (57%), Positives = 344/491 (70%), Gaps = 43/491 (8%)
Query: 99 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 158
C+V+LLD + YEC VEKH +GQ L VCEHLNLLE+DYFGL D + K WLD +KEI
Sbjct: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEI 62
Query: 159 KKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 218
KKQ+R PWNF F VKFYPPDPAQLTEDITRYYLCLQLR DI+ GRLPCSF T ALLGSY
Sbjct: 63 KKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSY 122
Query: 219 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 278
+Q+ELGDYD E H +YVS+ + APNQT+ELEE++MELHK+YR MTP +A++ FLENAK
Sbjct: 123 TIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAK 182
Query: 279 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 338
KLSMYGVDLH AKD EG+DI+LGVC++GLL+Y+D+LRINRF WPK+LKISYKRS+F+IKI
Sbjct: 183 KLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKI 242
Query: 339 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSKFRYSG 397
RPGE EQ+ESTIGFKLP++R+AK+LWKVC+EHHTFFRL S + PK FL +GSKFRYSG
Sbjct: 243 RPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSG 302
Query: 398 RTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGP------- 450
RTQAQTRQASALIDRPAP FER++SKR SRSLDGA A S + P
Sbjct: 303 RTQAQTRQASALIDRPAPHFERTASKR--ASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
Query: 451 -DGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQ-ETTP------------------ 490
+G D + +A++ V+ K ++ PEQ E P
Sbjct: 361 AEGGVLDASAKK-TVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYI 419
Query: 491 RHKQ---EFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERE-------RRLPS 540
RH E LDK ++ + KH ASI+ELK+ E S R +W++ R L
Sbjct: 420 RHSNLMLEDLDKSQEEIKKHHASISELKKNFME--SVPEPRPSEWDKRLSTHSPFRTLNI 477
Query: 541 SPASPSPKGTP 551
+ P+ +G P
Sbjct: 478 NGQIPTGEGPP 488
Score = 89.0 bits (219), Expect = 2e-17
Identities = 50/103 (48%), Positives = 64/103 (62%), Gaps = 2/103 (1%)
Query: 772 GPQTVATEIRSLSPIIG--KDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRII 829
GP V T+ ++S K + + T + + T +TVKGG SETRIEKRI+
Sbjct: 486 GPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIV 545
Query: 830 ITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPE 872
ITGD D+D DQ L AIKEAK QHPDM VTK VV++ET+ + E
Sbjct: 546 ITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 588
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 526 bits (1355), Expect = e-149
Identities = 284/509 (55%), Positives = 342/509 (67%), Gaps = 60/509 (11%)
Query: 99 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 158
C+V+LLD + YEC VEKH +GQ L VCEHLNLLE+DYFGL D + K WLD +KEI
Sbjct: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEI 62
Query: 159 KKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 218
KKQ+R PWNF F VKFYPPDPAQLTEDITRYYLCLQLR DI+ GRLPCSF T ALLGSY
Sbjct: 63 KKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSY 122
Query: 219 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 278
+Q+ELGDYD E H +YVS+ + APNQT+ELEE++MELHK+YR MTP +A++ FLENAK
Sbjct: 123 TIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAK 182
Query: 279 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 338
KLSMYGVDLH AKD EG+DI+LGVC++GLL+Y+D+LRINRF WPK+LKISYKRS+F+IKI
Sbjct: 183 KLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKI 242
Query: 339 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSKFRYSG 397
RPGE EQ+ESTIGFKLP++R+AK+LWKVC+EHHTFFRL S + PK FL +GSKFRYSG
Sbjct: 243 RPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSG 302
Query: 398 RTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGA-------EFSRPASV-------- 442
RTQAQTRQASALIDRPAP FER++SKR SRSLDGA RP S
Sbjct: 303 RTQAQTRQASALIDRPAPHFERTASKR--ASRSLDGAAAVDSADRSPRPTSAPAITQGQV 360
Query: 443 -----------------SENHDAGPDGDKRDEDGESG------GQRSEAEEGEVRTPT-- 477
++ + K DE E + E EV PT
Sbjct: 361 AEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSN 420
Query: 478 -----KIKELKPEQETTPRHKQ---EFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRD 529
K +E + RH E LDK ++ + KH ASI+ELK+ E S R
Sbjct: 421 GDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFME--SVPEPRP 478
Query: 530 RDWERE-------RRLPSSPASPSPKGTP 551
+W++ R L + P+ +G P
Sbjct: 479 SEWDKRLSTHSPFRTLNINGQIPTGEGPP 507
Score = 107 bits (266), Expect = 6e-23
Identities = 77/196 (39%), Positives = 105/196 (53%), Gaps = 23/196 (11%)
Query: 693 EPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDN---------TQQVDGSASVGREFIAT 743
E +K ++S L KK E+V + R S D T ++G G
Sbjct: 453 EEIKKHHASISEL---KKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEG---- 505
Query: 744 TPSITTETISTTME-NSLKSG---KGAAAMIPGPQTVATEIRSLSPIIGK---DVLTSTY 796
P + T+T++ + N++KS K + +T+ E G VL +
Sbjct: 506 PPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQ 565
Query: 797 GATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDM 856
T+ET S++TTT +TKTVKGG SETRIEKRI+ITGD D+D DQ L AIKEAK QHPDM
Sbjct: 566 TITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDM 625
Query: 857 LVTKAVVYRETDPSPE 872
VTK VV++ET+ + E
Sbjct: 626 SVTKVVVHQETEIADE 641
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 496 bits (1277), Expect = e-140
Identities = 277/532 (52%), Positives = 350/532 (65%), Gaps = 71/532 (13%)
Query: 50 SQQDTRPAEQSLDMEEKDYS--EADGLSE--------RTTPSKAQ---KSPQKIAKKYKS 96
S +T+PA++ L E+ D+ E +GL E + SKA+ K+ QK +K+++
Sbjct: 151 SSAETQPAQEEL-REDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRN 209
Query: 97 AICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSK 156
C+V+LLD + YEC VE WLD +K
Sbjct: 210 MHCKVSLLDDTVYECVVE-----------------------------------TWLDSAK 234
Query: 157 EIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLG 216
EIKKQ+R PWNF F VKFYPPDPAQLTEDITRYYLCLQLR DI+ GRLPCSF T ALLG
Sbjct: 235 EIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 294
Query: 217 SYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLEN 276
SY +Q+ELGDYD E H +YVS+ + APNQT+ELEE++MELHK+YR MTP +A++ FLEN
Sbjct: 295 SYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 354
Query: 277 AKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYI 336
AKKLSMYGVDLH AKD EG+DI+LGVC++GLL+Y+D+LRINRF WPK+LKISYKRS+F+I
Sbjct: 355 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 414
Query: 337 KIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG-FLVMGSKFRY 395
KIRPGE EQ+ESTIGFKLP++R+AK+LWKVC+EHHTFFRL S + PK FL +GSKFRY
Sbjct: 415 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRY 474
Query: 396 SGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGP----- 450
SGRTQAQTRQASALIDRPAP FER++SKR SRSLDGA A S + P
Sbjct: 475 SGRTQAQTRQASALIDRPAPHFERTASKR--ASRSLDGAAAVDSADRSPRPTSAPAITQG 532
Query: 451 ---DGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQ-ETTPRHKQEFLDKPEDVLLK 506
+G D + +A++ V+ K ++ PEQ E P + LDK ++ + K
Sbjct: 533 QVAEGGVLDASAKK-TVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDLDKSQEEIKK 591
Query: 507 HQASINELKRTLKEPNSKLIHRDRDWERE-------RRLPSSPASPSPKGTP 551
H ASI+ELK+ E S R +W++ R L + P+ +G P
Sbjct: 592 HHASISELKKNFME--SVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPP 641
Score = 107 bits (266), Expect = 6e-23
Identities = 77/196 (39%), Positives = 105/196 (53%), Gaps = 23/196 (11%)
Query: 693 EPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDN---------TQQVDGSASVGREFIAT 743
E +K ++S L KK E+V + R S D T ++G G
Sbjct: 587 EEIKKHHASISEL---KKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEG---- 639
Query: 744 TPSITTETISTTME-NSLKSG---KGAAAMIPGPQTVATEIRSLSPIIGK---DVLTSTY 796
P + T+T++ + N++KS K + +T+ E G VL +
Sbjct: 640 PPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQ 699
Query: 797 GATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDM 856
T+ET S++TTT +TKTVKGG SETRIEKRI+ITGD D+D DQ L AIKEAK QHPDM
Sbjct: 700 TITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDM 759
Query: 857 LVTKAVVYRETDPSPE 872
VTK VV++ET+ + E
Sbjct: 760 SVTKVVVHQETEIADE 775
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 322 bits (824), Expect = 1e-87
Identities = 171/399 (42%), Positives = 247/399 (61%), Gaps = 11/399 (2%)
Query: 92 KKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKN- 150
+++ +C + LLD + +V KH +GQVL D+V +HL+L E+DYFGL D DS N
Sbjct: 24 RQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLAD-DSTDNP 82
Query: 151 -WLDPSKEIKKQI-RSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCS 208
WLDP+K I+KQ+ R SP++ F VKF+ DP +L E+ TRY LQ++ DI+TGRLPC
Sbjct: 83 RWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCP 142
Query: 209 FVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGE 268
T ALL S+AVQ+ELGDYD E++ Y+S+ F PNQ ++ E+ I +LH+ + G++P E
Sbjct: 143 SNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAE 202
Query: 269 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKIS 328
AE ++L A+ L +YGV+ H+A+D +IM+GV + G+LIY++R+R+N F W KI+KIS
Sbjct: 203 AEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKIS 262
Query: 329 YKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGF-- 386
+K F+I++R +E E+ +GF + N+R+ K LWK C+EHHTFFRL P PP K F
Sbjct: 263 FKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFA 322
Query: 387 --LVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSE 444
+GSKFRY GRT+ Q+ Q F RS SK ++R L E S+S+
Sbjct: 323 HYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSK--PLARKLMDWEVVSRNSISD 380
Query: 445 NHDAGPDGDKRDEDGESGGQRSE-AEEGEVRTPTKIKEL 482
+ R G + S +EG P+ + L
Sbjct: 381 DRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHL 419
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 282 bits (721), Expect = 1e-75
Identities = 167/443 (37%), Positives = 248/443 (55%), Gaps = 19/443 (4%)
Query: 75 SERTTPSKAQKSPQKI--AKKYKSAI-CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLN 131
+E+ +AQ++ I A KS I CRV+LLD ++ ++ K +GQ LFD + HL+
Sbjct: 18 AEKERLREAQRAATHIPAAGDSKSIITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLD 77
Query: 132 LLEKDYFGLTFCDADSQKNWLDPSKEIKKQIR-SSPWNFAFTVKFYPPDPAQLTEDITRY 190
L+E DYFGL F D+ +WLD +K IKKQ++ SP+ VKFY +P L E++TRY
Sbjct: 78 LIESDYFGLRFMDSAQVAHWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRY 137
Query: 191 YLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL 250
LQL+ DI++G+L C F T L +Y +QAELGDYD EH VSE RF P QT E+
Sbjct: 138 LFVLQLKQDILSGKLDCPFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEM 197
Query: 251 EERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIY 310
E I E K YRG TP +AE ++L AK L MYGVD+H K +G D LG+ G+L++
Sbjct: 198 ELAIFEKWKEYRGQTPAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVF 257
Query: 311 RDRLRINRFAWPKILKISYKRSNFYIKI--RPGEYEQFESTIGFKLPNHRSAKRLWKVCI 368
+I F WPKI ++ +K++ + + + ++ E T F+L + ++ K LWK +
Sbjct: 258 EGDTKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAV 317
Query: 369 EHHTFFRLVSP---EPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRY 425
EHH FFRL P GF+ +GS+FRYSG+T+ QT + + R + FER SKRY
Sbjct: 318 EHHAFFRLRGPVQKSSHRSGFIRLGSRFRYSGKTEYQTTKTNKA--RRSTSFERRPSKRY 375
Query: 426 TMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRS----EAEEGEVRTPTKIKE 481
+ A ++P +S +++ + ++ G RS P +I+
Sbjct: 376 SRRTLQMKACATKPEELSVHNNVSTQSNGSQ---QAWGMRSALPVSPSISSAPVPVEIEN 432
Query: 482 LKPEQETTPRHKQEFLDKPEDVL 504
L P+ T +H ++ + D+L
Sbjct: 433 L-PQSPGTDQHDRKCIPLNIDLL 454
>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
1 [Homo sapiens]
Length = 518
Score = 265 bits (676), Expect = 2e-70
Identities = 142/337 (42%), Positives = 199/337 (59%), Gaps = 8/337 (2%)
Query: 99 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 158
CRV LLD +E ++ KH +GQ LFD + HL+L+E DYFGL F D+ +WLD +K I
Sbjct: 87 CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146
Query: 159 KKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 217
KKQ++ P + F VK+Y +P L E+ TRY LQLR DI++G+L C + T L +
Sbjct: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206
Query: 218 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENA 277
+QAELG+ + EH VSE RF PNQT +E I + K RG +P +AE+ +L A
Sbjct: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKA 266
Query: 278 KKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK 337
K L MYGVD+H + +G + LG+ G+LI+ +I F WPKI K+ +K+S +
Sbjct: 267 KWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLV 326
Query: 338 IRPGEYE--QFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSP---EPPPKGFLVMGSK 392
+ + + + E T F+L + R+ K LWK +EHH FFRL +P + F+ +GS+
Sbjct: 327 VVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSR 386
Query: 393 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSR 429
FR+SGRT+ Q S L R FER SKRY R
Sbjct: 387 FRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421
>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
2 [Homo sapiens]
Length = 900
Score = 265 bits (676), Expect = 2e-70
Identities = 142/337 (42%), Positives = 199/337 (59%), Gaps = 8/337 (2%)
Query: 99 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 158
CRV LLD +E ++ KH +GQ LFD + HL+L+E DYFGL F D+ +WLD +K I
Sbjct: 87 CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146
Query: 159 KKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 217
KKQ++ P + F VK+Y +P L E+ TRY LQLR DI++G+L C + T L +
Sbjct: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206
Query: 218 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENA 277
+QAELG+ + EH VSE RF PNQT +E I + K RG +P +AE+ +L A
Sbjct: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKA 266
Query: 278 KKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK 337
K L MYGVD+H + +G + LG+ G+LI+ +I F WPKI K+ +K+S +
Sbjct: 267 KWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLV 326
Query: 338 IRPGEYE--QFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSP---EPPPKGFLVMGSK 392
+ + + + E T F+L + R+ K LWK +EHH FFRL +P + F+ +GS+
Sbjct: 327 VVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSR 386
Query: 393 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSR 429
FR+SGRT+ Q S L R FER SKRY R
Sbjct: 387 FRFSGRTEYQATHGSRL--RRTSTFERKPSKRYPSRR 421
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 262 bits (670), Expect = 9e-70
Identities = 171/517 (33%), Positives = 253/517 (48%), Gaps = 60/517 (11%)
Query: 99 CRVTLLDASEYECEVEKHG-----RGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLD 153
C V LLD S+ ++ G +G V+ D V H+NL+E DYFGL +CD Q WLD
Sbjct: 13 CEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLD 72
Query: 154 PSK---EIKKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSF 209
P+K E K+ I + P + F +KFY DP +L E+ITRY LQ++ D++ GRLPC
Sbjct: 73 PAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPV 132
Query: 210 VTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEA 269
T A LG+YA+Q+ELGDYD +H YVSE RF P+Q ELEE I +HKT G P EA
Sbjct: 133 NTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSEA 192
Query: 270 EIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISY 329
E+++L AK L MYGVDLH + LG+ G+++Y+++ ++ ++ WP+I K+ +
Sbjct: 193 ELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHF 252
Query: 330 KRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVM 389
K + F +++ + E++ F+ + + K LWK +EHHTFFR+ PE
Sbjct: 253 KETQFELRVLGKDCN--ETSFFFEARSKTACKHLWKCSVEHHTFFRM--PENESNSLSRK 308
Query: 390 GSKF-------RYSGRTQAQ-TRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPAS 441
SKF RYSGRT Q +R S + RP RS SK Y P
Sbjct: 309 LSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTY-------------PKR 355
Query: 442 VSENHDAGPDGDKRDEDGESGGQRSEAEEGEVR--TPTKIKELKPEQETTPRHKQEFLDK 499
+++ A + R G+ EG ++ P+ +K K K + +
Sbjct: 356 IAQTQPAESNSISRITANMENGE----NEGTIKIIAPSPVKSFK---------KAKNENS 402
Query: 500 PEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLP----SSPASPSPKGTPEKAN 555
P+ K A E P S L + D + + P +P+ S + +
Sbjct: 403 PDTQRSKSHAPWEE-----NGPQSGLYNSPSDRTKSPKFPYTRRRNPSCGSDNDSVQPVR 457
Query: 556 ERAGLREGSEEKVKPPRPRAPESDT--GDEDQDQERD 590
R G + +K R +T G E ++ R+
Sbjct: 458 RRKAHNSGEDSDLKQRRRSRSRCNTSSGSESENSNRE 494
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 256 bits (654), Expect = 6e-68
Identities = 148/357 (41%), Positives = 207/357 (57%), Gaps = 8/357 (2%)
Query: 78 TTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDY 137
+T + QK P + K S ++ +LD ++ EV + G+VL D VC HLNL+E DY
Sbjct: 23 STLERGQKPPPTPSGKLVSI--KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDY 80
Query: 138 FGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFA-FTVKFYPPDPAQLTEDITRYYLCLQL 196
FGL F D WLD K I KQIR F VKF+PPD QL E++TRY LQ+
Sbjct: 81 FGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQV 140
Query: 197 RADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIME 256
+ D+ GRL C+ + ALL S+ VQ+E+GD+D E ++++ ++ P Q LE++I+E
Sbjct: 141 KQDLAQGRLTCNDTSAALLISHIVQSEIGDFD-EALDREHLAKNKYIPQQDA-LEDKIVE 198
Query: 257 LHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRI 316
H + G TP E++ LE A++L MYG+ LH AKD EG I L V G+L+++ +I
Sbjct: 199 FHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKI 258
Query: 317 NRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL 376
N F W K+ K+S+KR F IK+RP ++ T+ F + + K WK+C+EHH FFRL
Sbjct: 259 NAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRL 318
Query: 377 V-SPEPPPKGFLV-MGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSL 431
P+P PK L GS FR+SGRTQ Q FER SK +++ RSL
Sbjct: 319 FEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSI-RSL 374
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 255 bits (652), Expect = 1e-67
Identities = 133/341 (39%), Positives = 196/341 (57%), Gaps = 11/341 (3%)
Query: 86 SPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDA 145
S + + ++Y C V LLD SEY C +++ +GQ LFDL+C HLNLLEKDYFG+ F D
Sbjct: 9 SSRSLEREYS---CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDP 65
Query: 146 DSQKNWLDPSKEIKKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGR 204
D Q++WL+ +K + KQ+RS P + F VKFYP DPA L E+ITRY + LQ++ D+ GR
Sbjct: 66 DKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGR 125
Query: 205 LPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKT-YRG 263
L C ALL +Y +QAE+GDYD+ +H Y S+ +F P + +LE +I E+HKT G
Sbjct: 126 LLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSG 185
Query: 264 MTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPK 323
TP +E++FL A+ L YGVD H KD G L G ++ + R++ W +
Sbjct: 186 QTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNE 245
Query: 324 ILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEP-- 381
+ K+ ++ FY+ + + E+ + + + P + K LWK IE+ F++L
Sbjct: 246 VTKLKFEGKTFYLYV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVR 303
Query: 382 --PPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERS 420
GS+FRYSGR + ++SA I R P R+
Sbjct: 304 TVSSSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRA 344
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 254 bits (649), Expect = 2e-67
Identities = 130/340 (38%), Positives = 196/340 (57%), Gaps = 9/340 (2%)
Query: 99 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 158
C + LLD SE C +++ +GQ L D +C + +LLEKDYFG+ + D + Q++WL+P+K I
Sbjct: 34 CTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSI 93
Query: 159 KKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 217
KQ+++ P + F VKFYP +P ++ E++TRY L LQ++ DI GRL CSF A LG+
Sbjct: 94 FKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGA 153
Query: 218 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKT-YRGMTPGEAEIHFLEN 276
VQAELGDYD +EH NY+SE P Q+++LE +I+E+HK RG +P AE + L
Sbjct: 154 CIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLK 213
Query: 277 AKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYI 336
A L YGVD H KDS G LG A G ++++ RI+ WP + K+ ++ FY+
Sbjct: 214 AHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYV 273
Query: 337 KIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEP----PPKGFLVMGSK 392
G ++ ++ + F + K LWK +E+ F++ GS+
Sbjct: 274 ---IGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSR 330
Query: 393 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLD 432
FRYSG+ + +AS+ I R P R++ + S SL+
Sbjct: 331 FRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLN 370
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 243 bits (619), Expect = 7e-64
Identities = 141/337 (41%), Positives = 193/337 (57%), Gaps = 9/337 (2%)
Query: 100 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 159
RV LLD + ++E GQVL V + LNL+E DYFG+ F + S WL+P K I
Sbjct: 47 RVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPII 106
Query: 160 KQIRSSPWNFAF--TVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGS 217
+QIR P N VKF+PPDP QL E+ TRY LQL+ D++ RL C+ T ALL S
Sbjct: 107 RQIRR-PKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTS 165
Query: 218 YAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENA 277
+ +Q+E+GDYD E ++ + P Q LE +I+E H+ + G TP E++ LE A
Sbjct: 166 HLLQSEIGDYD-ETLDREHLKVNEYLPGQQHCLE-KILEFHQKHVGQTPAESDFQVLEIA 223
Query: 278 KKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK 337
+KL MYG+ H A D EG I L V G+L+++ +IN F W K+ K+S+KR F IK
Sbjct: 224 RKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIK 283
Query: 338 IRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG---FLVMGSKFR 394
+ P + ++ T+ F L + K WK+C+E+HTFFRL+ +P PK F GS FR
Sbjct: 284 LHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLD-QPKPKAKAVFFSRGSSFR 342
Query: 395 YSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSL 431
YSGRTQ Q +ER SK +T R+L
Sbjct: 343 YSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRAL 379
>gi|34916000 FERM domain containing 7 [Homo sapiens]
Length = 714
Score = 240 bits (613), Expect = 4e-63
Identities = 149/409 (36%), Positives = 217/409 (53%), Gaps = 17/409 (4%)
Query: 100 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 159
+V LD S+ V++ G+ LF+L C HLNL EK+YFGL FC WL+ K I
Sbjct: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64
Query: 160 KQIRS-SPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY 218
KQ+++ F F VKF+P DP L E++TRY LQ++ D+ GRLPCS AL+ S+
Sbjct: 65 KQVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSH 124
Query: 219 AVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAK 278
+Q+ELGD+ EE ++++ R+ PNQ LE +IM H+ + G +P E++I L+ A+
Sbjct: 125 ILQSELGDFH-EETDRKHLAQTRYLPNQDC-LEGKIMHFHQKHIGRSPAESDILLLDIAR 182
Query: 279 KLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKI 338
KL MYG+ H A D EG+ I L V G+L+ R +IN F W KI K+S+KR +F IK+
Sbjct: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
Query: 339 RPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL-VSPEPPPKGFLV-MGSKFRYS 396
+ T+ F + + + K WK C+E+H FFRL P+ PK L GS FRYS
Sbjct: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRLSEEPKSKPKTLLCSKGSSFRYS 302
Query: 397 GRTQAQT-------RQASALIDR---PAPFFERSSSKRYTMSRSLDGAEFSRPASVSENH 446
GRTQ Q R S +R P+ + ER + + + +
Sbjct: 303 GRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRSSPDLLSDVSKQVEDLRLAYGGGY 362
Query: 447 DAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQE 495
+G E +R+ A EV T+++ KPE + T H+ +
Sbjct: 363 YQNVNGVHASEPVLESRRRNSAL--EVTFATELEHSKPEADPTLLHQSQ 409
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 224 bits (572), Expect = 2e-58
Identities = 128/348 (36%), Positives = 189/348 (54%), Gaps = 11/348 (3%)
Query: 92 KKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCD--ADSQK 149
K IC + LD +V K GQVL D+V HL + EK+YFGL D DS +
Sbjct: 24 KTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPR 83
Query: 150 NWLDPSKEIKKQIRSS-PWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCS 208
WL+ SK I+KQ++ P F V+F+ PDP L ++ TR+ LQL+ DI GRL C
Sbjct: 84 -WLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCP 142
Query: 209 FVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGE 268
+ +L SYAVQ+ GDY++ H Y+S+ F P+Q + ++ LH+ + G+ E
Sbjct: 143 LNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSE 202
Query: 269 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKIS 328
AE ++ A+ L YGV+LH +D +D+M+G+ + G+ +YR + + + W ILKIS
Sbjct: 203 AESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKIS 262
Query: 329 YKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFL- 387
+KR F+I R + E E + F + N+RS K LWK C+EHHTFF+ P K L
Sbjct: 263 FKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLS 322
Query: 388 ---VMGSK-FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSL 431
MGS+ + S Q + ++ PA RS S + ++SL
Sbjct: 323 QYWTMGSRNTKKSVNNQYCKKVIGGMVWNPA--MRRSLSVEHLETKSL 368
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 223 bits (569), Expect = 5e-58
Identities = 119/308 (38%), Positives = 173/308 (56%), Gaps = 8/308 (2%)
Query: 92 KKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCD--ADSQK 149
K IC + LD +V K GQVL D+V HL + EK+YFGL D DS +
Sbjct: 24 KTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPR 83
Query: 150 NWLDPSKEIKKQIRSS-PWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCS 208
WL+ SK I+KQ++ P F V+F+ PDP L ++ TR+ LQL+ DI GRL C
Sbjct: 84 -WLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCP 142
Query: 209 FVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGE 268
+ +L SYAVQ+ GDY++ H Y+S+ F P+Q + ++ LH+ + G+ E
Sbjct: 143 LNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSE 202
Query: 269 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKIS 328
AE ++ A+ L YGV+LH +D +D+M+G+ + G+ +YR + + + W ILKIS
Sbjct: 203 AESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKIS 262
Query: 329 YKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFL- 387
+KR F+I R + E E + F + N+RS K LWK C+EHHTFF+ P K L
Sbjct: 263 FKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLS 322
Query: 388 ---VMGSK 392
MGS+
Sbjct: 323 QYWTMGSR 330
>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
isoform 3 [Homo sapiens]
Length = 782
Score = 155 bits (391), Expect = 2e-37
Identities = 84/238 (35%), Positives = 129/238 (54%), Gaps = 7/238 (2%)
Query: 199 DIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELH 258
DI GRL C + +L SYAVQ+ GDY++ H Y+S+ F P+Q + ++ LH
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 259 KTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINR 318
+ + G+ EAE ++ A+ L YGV+LH +D +D+M+G+ + G+ +YR + +
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 319 FAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVS 378
+ W ILKIS+KR F+I R + E E + F + N+RS K LWK C+EHHTFF+
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
Query: 379 PEPPPKGFL----VMGSK-FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSL 431
P K L MGS+ + S Q + ++ PA RS S + ++SL
Sbjct: 182 LLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPA--MRRSLSVEHLETKSL 237
>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
Length = 737
Score = 154 bits (388), Expect = 5e-37
Identities = 75/198 (37%), Positives = 113/198 (57%), Gaps = 4/198 (2%)
Query: 199 DIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELH 258
DI GRL C + +L SYAVQ+ GDY++ H Y+S+ F P+Q + ++ LH
Sbjct: 2 DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLH 61
Query: 259 KTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINR 318
+ + G+ EAE ++ A+ L YGV+LH +D +D+M+G+ + G+ +YR + +
Sbjct: 62 EQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSF 121
Query: 319 FAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVS 378
+ W ILKIS+KR F+I R + E E + F + N+RS K LWK C+EHHTFF+
Sbjct: 122 YPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 181
Query: 379 PEPPPKGFL----VMGSK 392
P K L MGS+
Sbjct: 182 LLPQEKNVLSQYWTMGSR 199
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 154 bits (388), Expect = 5e-37
Identities = 89/289 (30%), Positives = 149/289 (51%), Gaps = 16/289 (5%)
Query: 98 ICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKE 157
+ R+ LL+ E + GQ + V + L L E YF L + + +Q+ W+D K
Sbjct: 24 VARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKP 83
Query: 158 IKKQIRSSPWN--FAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALL 215
+KKQ+ F V FY P +QL ++ITRY LQL+ DI+ G +PC+ L
Sbjct: 84 LKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQL 143
Query: 216 GSYAVQAELGDYDAEEHVGNYVSELRFAP-------NQTRELEERIMELHKTYRGMTPGE 268
AVQA+ GD+D E +++ + P E +++ LH+ YRG+T +
Sbjct: 144 AGLAVQADFGDFDQYES-QDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPD 202
Query: 269 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLI-YRDRLRINRFAWPKILKI 327
AE+ +++ +++ YG + + AKDS+G DI +G C G+ + +++ F W I +
Sbjct: 203 AEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANM 262
Query: 328 SYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRL 376
S+ +S F + E E TI F+ + +AK +W++C+ H F+RL
Sbjct: 263 SHNKSFFAL-----ELANKEETIQFQTEDMETAKYIWRLCVARHKFYRL 306
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 153 bits (386), Expect = 8e-37
Identities = 145/553 (26%), Positives = 233/553 (42%), Gaps = 58/553 (10%)
Query: 100 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 159
RVT +DA E E ++ + G+ LFD V + + L E YFGL + D WL K++
Sbjct: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS 66
Query: 160 KQI--RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVTHALLG 216
Q + +P F F KFYP D A+ L +DIT+ LQ++ I++ + C T LLG
Sbjct: 67 AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLG 126
Query: 217 SYAVQAELGDYDAEEHVGNYVSELRFAPNQTR--------ELEERIMELHKTYRGMTPGE 268
SYAVQA+ GDY+ E H Y+S R P + + E+RI H +RGM
Sbjct: 127 SYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDN 186
Query: 269 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFAWPKIL 325
A + +L+ A+ L MYG++ K+ +G D+ LGV A GL IY ++ F W +I
Sbjct: 187 AMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR 246
Query: 326 KISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG 385
IS+ F IK + F F P R KR+ ++C+ +H L P
Sbjct: 247 NISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILQLCMGNH---ELYMRRRKPDT 299
Query: 386 FLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSEN 445
V K QA+ + ++R E +R T+ R + + +
Sbjct: 300 IEVQQMK------AQAREEKHQKQLERQQ--LETEKKRRETVEREKEQMMREKEELMLRL 351
Query: 446 HDAGPDGDKRDEDGESGGQRS-EAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVL 504
D K + + QR+ + EE R + + L+ ++ R K+E + D +
Sbjct: 352 QDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQI 411
Query: 505 LKHQASINELKR------TLKEPNSKLIHRDRDWERERR----------------LPSSP 542
+ EL L+E + +W+ + + + P
Sbjct: 412 KSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPP 471
Query: 543 ASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE 602
P P P + + L+ +E +P A S G D E + + + ++
Sbjct: 472 PPPPPVYEPVSYHVQESLQ---DEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQ 528
Query: 603 RKCSSITVSSTSS 615
R+ +T+SS S
Sbjct: 529 RQL--LTLSSELS 539
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 153 bits (386), Expect = 8e-37
Identities = 145/553 (26%), Positives = 233/553 (42%), Gaps = 58/553 (10%)
Query: 100 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 159
RVT +DA E E ++ + G+ LFD V + + L E YFGL + D WL K++
Sbjct: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS 66
Query: 160 KQI--RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVTHALLG 216
Q + +P F F KFYP D A+ L +DIT+ LQ++ I++ + C T LLG
Sbjct: 67 AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLG 126
Query: 217 SYAVQAELGDYDAEEHVGNYVSELRFAPNQTR--------ELEERIMELHKTYRGMTPGE 268
SYAVQA+ GDY+ E H Y+S R P + + E+RI H +RGM
Sbjct: 127 SYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDN 186
Query: 269 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFAWPKIL 325
A + +L+ A+ L MYG++ K+ +G D+ LGV A GL IY ++ F W +I
Sbjct: 187 AMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR 246
Query: 326 KISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG 385
IS+ F IK + F F P R KR+ ++C+ +H L P
Sbjct: 247 NISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILQLCMGNH---ELYMRRRKPDT 299
Query: 386 FLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSEN 445
V K QA+ + ++R E +R T+ R + + +
Sbjct: 300 IEVQQMK------AQAREEKHQKQLERQQ--LETEKKRRETVEREKEQMMREKEELMLRL 351
Query: 446 HDAGPDGDKRDEDGESGGQRS-EAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVL 504
D K + + QR+ + EE R + + L+ ++ R K+E + D +
Sbjct: 352 QDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQI 411
Query: 505 LKHQASINELKR------TLKEPNSKLIHRDRDWERERR----------------LPSSP 542
+ EL L+E + +W+ + + + P
Sbjct: 412 KSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPP 471
Query: 543 ASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE 602
P P P + + L+ +E +P A S G D E + + + ++
Sbjct: 472 PPPPPVYEPVSYHVQESLQ---DEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQ 528
Query: 603 RKCSSITVSSTSS 615
R+ +T+SS S
Sbjct: 529 RQL--LTLSSELS 539
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 146 bits (369), Expect = 7e-35
Identities = 139/536 (25%), Positives = 220/536 (41%), Gaps = 47/536 (8%)
Query: 95 KSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDP 154
K+ RVT +DA E E ++ + G+ LFD V + + L E +FGL + D WL
Sbjct: 3 KTISVRVTTMDA-ELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
Query: 155 SKEIKKQI--RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVT 211
+K++ Q + SP F F KFYP D ++ L +DIT+ LQ++ I+ + C T
Sbjct: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
Query: 212 HALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHKTYRG 263
LL SYAVQ++ GD++ E H Y++ + P + E EERI H+ +RG
Sbjct: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
Query: 264 MTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFA 320
M +A + +L+ A+ L MYGV+ K+ +G ++ LGV A GL IY R+ F
Sbjct: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
Query: 321 WPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPE 380
W +I IS+ F IK + F F P R KR+ +C+ +H L
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNH---ELYMRR 294
Query: 381 PPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPA 440
P V K AQ R+ E KR + + E +
Sbjct: 295 RKPDTIEVQQMK--------AQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEE 346
Query: 441 SVSENHDAGPDGDKRDEDGESGGQRS-EAEEGEVRTPTKIKELKPEQETTPRHKQEFLD- 498
+ K ++ E +R+ E E+ R ++ ++L E++ K+ L
Sbjct: 347 LMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQA 406
Query: 499 -----KPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWER----------ERRLPSSPA 543
K ++ L A + L+ K +W++ + R A
Sbjct: 407 SRDQKKTQEQLALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTA 466
Query: 544 SPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHL 599
+P NE+ E E R A D +E++ E + HL
Sbjct: 467 MSTPHVAEPAENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHL 522
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 143 bits (360), Expect = 8e-34
Identities = 131/495 (26%), Positives = 217/495 (43%), Gaps = 35/495 (7%)
Query: 100 RVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIK 159
RVT +DA E E ++ + G+ LFD V + + L E +FGL + D+ WL +K++
Sbjct: 8 RVTTMDA-ELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVT 66
Query: 160 KQI--RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVTHALLG 216
+Q + +P F F KF+P D ++ L ++IT+ LQ++ I+ + C T LL
Sbjct: 67 QQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLA 126
Query: 217 SYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHKTYRGMTPGE 268
SYAVQA+ GDY+ E H Y++ R P + E EERI H+ +RGM +
Sbjct: 127 SYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLRED 186
Query: 269 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFAWPKIL 325
+ + +L+ A+ L MYGV+ K+ +G ++ LGV A GL IY ++ F W +I
Sbjct: 187 SMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIR 246
Query: 326 KISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG 385
IS+ F IK + F F P R KR+ +C+ +H + + +P
Sbjct: 247 NISFNDKKFVIKPIDKKAPDFV----FYAPRLRINKRILALCMGNHELY-MRRRKPDTIE 301
Query: 386 FLVMGSKFRYSGRTQAQTRQASALIDRPAPFF-----ERSSSKRYTMSRSLDGAEFSRPA 440
M ++ R + Q Q +A ++ ER ++ + L E
Sbjct: 302 VQQMKAQAR-EEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIK 360
Query: 441 SVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKP 500
+ E + + D++ + + +E E E R + K +Q QE L
Sbjct: 361 AQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAE 420
Query: 501 EDVLLKHQASINELKRTLKEPNSKLIHR----DRDWERERR-----LPSSPASPSPKGTP 551
A + E K+ +E ++ H+ D E+ + + + P P P P
Sbjct: 421 LAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIP 480
Query: 552 EKANERAGLREGSEE 566
NE E + E
Sbjct: 481 PTENEHDEHDENNAE 495
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 139 bits (350), Expect = 1e-32
Identities = 97/298 (32%), Positives = 151/298 (50%), Gaps = 22/298 (7%)
Query: 92 KKYKSAICRVTLLDAS-EYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKN 150
K+ K+ R+ +DA E+ CE++ +G+ LFDLVC L L E +FGL + D+
Sbjct: 17 KQPKTFTVRIVTMDAEMEFNCEMK--WKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVA- 73
Query: 151 WLDPSKEIKKQ--IRSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPC 207
WL K++ + P F F KFYP + + L ++IT++ LQ++ I+ ++ C
Sbjct: 74 WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 133
Query: 208 SFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHK 259
LL SYAVQA+ GDYD H ++++ P + L EERI +
Sbjct: 134 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYA 193
Query: 260 TYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN-- 317
+RG EAE+ +L+ A+ L MYGV+ ++ +G +++LGV A GL IY R+
Sbjct: 194 EHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPK 253
Query: 318 -RFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 374
F W +I ISY F IK + + F+ F R K + ++CI +H F
Sbjct: 254 ISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 307
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 139 bits (350), Expect = 1e-32
Identities = 97/298 (32%), Positives = 151/298 (50%), Gaps = 22/298 (7%)
Query: 92 KKYKSAICRVTLLDAS-EYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKN 150
K+ K+ R+ +DA E+ CE++ +G+ LFDLVC L L E +FGL + D+
Sbjct: 17 KQPKTFTVRIVTMDAEMEFNCEMK--WKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVA- 73
Query: 151 WLDPSKEIKKQ--IRSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPC 207
WL K++ + P F F KFYP + + L ++IT++ LQ++ I+ ++ C
Sbjct: 74 WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 133
Query: 208 SFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHK 259
LL SYAVQA+ GDYD H ++++ P + L EERI +
Sbjct: 134 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYA 193
Query: 260 TYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN-- 317
+RG EAE+ +L+ A+ L MYGV+ ++ +G +++LGV A GL IY R+
Sbjct: 194 EHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPK 253
Query: 318 -RFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 374
F W +I ISY F IK + + F+ F R K + ++CI +H F
Sbjct: 254 ISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 307
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.368
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,271,372
Number of Sequences: 37866
Number of extensions: 1896291
Number of successful extensions: 9877
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 96
Number of HSP's successfully gapped in prelim test: 343
Number of HSP's that attempted gapping in prelim test: 8643
Number of HSP's gapped (non-prelim): 1393
length of query: 881
length of database: 18,247,518
effective HSP length: 111
effective length of query: 770
effective length of database: 14,044,392
effective search space: 10814181840
effective search space used: 10814181840
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.