Search of human proteins with 30023818

Search of human proteins with 30023818

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30023818 tripartite motif protein 50A [Homo sapiens]
         (487 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30023818 tripartite motif protein 50A [Homo sapiens]              1012   0.0  
gi|38524612 tripartite motif-containing 74 [Homo sapiens]             478   e-135
gi|65285121 tripartite motif-containing 73 [Homo sapiens]             472   e-133
gi|56605981 tripartite motif-containing 72 [Homo sapiens]             273   3e-73
gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]   228   1e-59
gi|217035095 tripartite motif-containing 62 [Homo sapiens]            219   4e-57
gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]   218   8e-57
gi|112421127 tripartite motif-containing 58 [Homo sapiens]            213   3e-55
gi|88999601 tripartite motif-containing 69 isoform a [Homo sapiens]   210   2e-54
gi|5730009 ret finger protein [Homo sapiens]                          207   2e-53
gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens]    200   2e-51
gi|21630277 tripartite motif-containing 11 [Homo sapiens]             186   5e-47
gi|15208660 tripartite motif protein 21 [Homo sapiens]                185   9e-47
gi|37622899 ring finger protein 137 [Homo sapiens]                    179   7e-45
gi|22749269 ring finger protein 129 [Homo sapiens]                    170   2e-42
gi|157426898 tripartite motif-containing 10 isoform 1 [Homo sapi...   170   2e-42
gi|18079262 tripartite motif-containing 6 isoform 2 [Homo sapiens]    170   3e-42
gi|51477692 tripartite motif-containing 6 isoform 1 [Homo sapiens]    170   3e-42
gi|14719418 tripartite motif protein TRIM5 isoform alpha [Homo s...   162   5e-40
gi|94536782 tripartite motif-containing 35 isoform 2 [Homo sapiens]   159   7e-39
gi|31542779 tripartite motif family-like 1 [Homo sapiens]             157   2e-38
gi|42516572 tripartite motif-containing 41 isoform 1 [Homo sapiens]   157   3e-38
gi|37595541 tripartite motif-containing 69 isoform b [Homo sapiens]   156   4e-38
gi|68160933 tripartite motif-containing 17 isoform 1 [Homo sapiens]   154   2e-37
gi|7705825 tripartite motif-containing 17 isoform 1 [Homo sapiens]    154   2e-37
gi|51477687 tripartite motif protein 34 isoform 1 [Homo sapiens]      151   1e-36
gi|18087807 tripartite motif protein 34 isoform 1 [Homo sapiens]      151   1e-36
gi|51477690 tripartite motif-containing 6 and tripartite motif-c...   151   1e-36
gi|117938316 tripartite motif-containing 22 [Homo sapiens]            150   3e-36
gi|15011941 tripartite motif protein TRIM4 isoform beta [Homo sa...   149   7e-36

>gi|30023818 tripartite motif protein 50A [Homo sapiens]
          Length = 487

 Score = 1012 bits (2616), Expect = 0.0
 Identities = 487/487 (100%), Positives = 487/487 (100%)

Query: 1   MAWQVSLLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAV 60
           MAWQVSLLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAV
Sbjct: 1   MAWQVSLLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAV 60

Query: 61  DGSSSLPNVSLARVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHH 120
           DGSSSLPNVSLARVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHH
Sbjct: 61  DGSSSLPNVSLARVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHH 120

Query: 121 PVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQ 180
           PVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQ
Sbjct: 121 PVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQ 180

Query: 181 ELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHKF 240
           ELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHKF
Sbjct: 181 ELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHKF 240

Query: 241 IRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPEPLKLDP 300
           IRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPEPLKLDP
Sbjct: 241 IRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPEPLKLDP 300

Query: 301 ATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYWEVVVGSKSD 360
           ATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYWEVVVGSKSD
Sbjct: 301 ATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYWEVVVGSKSD 360

Query: 361 WRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGHPHRIGLYLHY 420
           WRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGHPHRIGLYLHY
Sbjct: 361 WRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGHPHRIGLYLHY 420

Query: 421 EQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPSGPGPLS 480
           EQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPSGPGPLS
Sbjct: 421 EQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPSGPGPLS 480

Query: 481 PEQPTKL 487
           PEQPTKL
Sbjct: 481 PEQPTKL 487


>gi|38524612 tripartite motif-containing 74 [Homo sapiens]
          Length = 250

 Score =  478 bits (1229), Expect = e-135
 Identities = 234/250 (93%), Positives = 238/250 (95%)

Query: 1   MAWQVSLLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAV 60
           MAWQVSLLELEDWLQCPICLEVFKE LMLQCGHSYCKGCLVSLS HLD ++RCP+C Q V
Sbjct: 1   MAWQVSLLELEDWLQCPICLEVFKESLMLQCGHSYCKGCLVSLSYHLDTKVRCPMCWQVV 60

Query: 61  DGSSSLPNVSLARVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHH 120
           DGSSSLPNVSLA VIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHH
Sbjct: 61  DGSSSLPNVSLAWVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHH 120

Query: 121 PVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQ 180
           PVTPVSTV SRMKEELAAL SELKQEQKKVDELIAKLV NRTRIVNESDVFSWVIRREFQ
Sbjct: 121 PVTPVSTVCSRMKEELAALFSELKQEQKKVDELIAKLVKNRTRIVNESDVFSWVIRREFQ 180

Query: 181 ELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHKF 240
           EL H VDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHH+F
Sbjct: 181 ELRHPVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHEF 240

Query: 241 IRKFHSMASR 250
           I KFHSMASR
Sbjct: 241 IWKFHSMASR 250


>gi|65285121 tripartite motif-containing 73 [Homo sapiens]
          Length = 250

 Score =  472 bits (1215), Expect = e-133
 Identities = 233/250 (93%), Positives = 237/250 (94%)

Query: 1   MAWQVSLLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAV 60
           MAWQVSLLELED LQCPICLEVFKE LMLQCGHSYCKGCLVSLS HLD ++RCP+C Q V
Sbjct: 1   MAWQVSLLELEDRLQCPICLEVFKESLMLQCGHSYCKGCLVSLSYHLDTKVRCPMCWQVV 60

Query: 61  DGSSSLPNVSLARVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHH 120
           DGSSSLPNVSLA VIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHH
Sbjct: 61  DGSSSLPNVSLAWVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHH 120

Query: 121 PVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQ 180
           PVTPVSTV SRMKEELAAL SELKQEQKKVDELIAKLV NRTRIVNESDVFSWVIRREFQ
Sbjct: 121 PVTPVSTVCSRMKEELAALFSELKQEQKKVDELIAKLVKNRTRIVNESDVFSWVIRREFQ 180

Query: 181 ELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHKF 240
           EL H VDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHH+F
Sbjct: 181 ELRHPVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHEF 240

Query: 241 IRKFHSMASR 250
           I KFHSMASR
Sbjct: 241 IWKFHSMASR 250


>gi|56605981 tripartite motif-containing 72 [Homo sapiens]
          Length = 477

 Score =  273 bits (698), Expect = 3e-73
 Identities = 162/484 (33%), Positives = 246/484 (50%), Gaps = 35/484 (7%)

Query: 10  LEDWLQCPICLEVFKEPLMLQCGHSYCKGCL--VSLSCHLDAELRCPVCRQAVDGSSSLP 67
           L   L CP+CL++F  P+  +CGHS+C+ CL  V+     D  + CP C+      +   
Sbjct: 8   LHQELSCPLCLQLFDAPVTAECGHSFCRACLGRVAGEPAADGTVLCPCCQAPTRPQALST 67

Query: 68  NVSLARVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVST 127
           N+ LAR++E L          C  H +PLS++CE+D+ L+CG+C  LGSH+ H + P + 
Sbjct: 68  NLQLARLVEGLAQVPQGH---CEEHLDPLSIYCEQDRALVCGVCASLGSHRGHRLLPAAE 124

Query: 128 VYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQE------ 181
            ++R+K +L     +L++   + ++ +A L +    +      F   +  +  +      
Sbjct: 125 AHARLKTQLPQQKLQLQEACMRKEKSVAVLEHQLVEVEETVRQFRGAVGEQLGKMRVFLA 184

Query: 182 -LHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHKF 240
            L   +D E  R     G   R  + SL+  LEQ       L Q E VLE+  ++   +F
Sbjct: 185 ALEGSLDCEAERVRGEAGVALRRELGSLNSYLEQ-------LRQMEKVLEEVADKPQTEF 237

Query: 241 IRKFHSMASR-----AEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPEP 295
           + K+  + SR     AE P    L+     IS        D K  VW+++FR ++PA E 
Sbjct: 238 LMKYCLVTSRLQKILAESPPPARLDIQLPIIS-------DDFKFQVWRKMFRALMPALEE 290

Query: 296 LKLDPATAHPLLELSKGNTVVQCG-LLAQRRASQPERFDYSTCVLASRGFSCGRHYWEVV 354
           L  DP++AHP L +S     V+C    A      P +FD +  V+A +  S G HYWEV 
Sbjct: 291 LTFDPSSAHPSLVVSSSGRRVECSEQKAPPAGEDPRQFDKAVAVVAHQQLSEGEHYWEVD 350

Query: 355 VGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAG---HP 411
           VG K  W LGVI   A R+G+L+  P  G+WL+GL+EG++ EA    + P  +      P
Sbjct: 351 VGDKPRWALGVIAAEAPRRGRLHAVPSQGLWLLGLREGKILEAHVEAKEPRALRSPERRP 410

Query: 412 HRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCWHERGSNSLPMVLP 471
            RIGLYL +  G L+F+DA   D L PL+ F       +YP  D CWH++G N+ P++L 
Sbjct: 411 TRIGLYLSFGDGVLSFYDASDADALVPLFAFHERLPRPVYPFFDVCWHDKGKNAQPLLLV 470

Query: 472 PPSG 475
            P G
Sbjct: 471 GPEG 474


>gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]
          Length = 488

 Score =  228 bits (580), Expect = 1e-59
 Identities = 145/486 (29%), Positives = 229/486 (47%), Gaps = 36/486 (7%)

Query: 6   SLLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAVDGSSS 65
           +L  L+    C +CLE  KEP++++CGH++CK C+      L+ +  CPVCR+     S 
Sbjct: 19  ALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSL 78

Query: 66  LPNVSLARVIEALRLPGDPEPKV-----CVHHRNPLSLFCEKDQELICGLCGLLGSHQHH 120
            PN  L  ++E  +     + K+     C  H   LSLFC +DQE +C +C +  +H+ H
Sbjct: 79  RPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAH 138

Query: 121 PVTPVSTVYSRMKEELAALISELKQ-----------EQKKVDELIAKLVNNRTRIVNESD 169
            V P+       KE+L   +  L+Q           E+KK  EL   + + R +I+    
Sbjct: 139 TVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQIL---- 194

Query: 170 VFSWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVL 229
                  REF+ELH  +DEE+   L  +    + ++  L          R  LA     +
Sbjct: 195 -------REFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEV 247

Query: 230 EQFGNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKV 289
           E    +   + ++   S   + E  + + +E     I  +        +    +++ +++
Sbjct: 248 EGKCLQSGFEMLKDVKSTLEKCE--KVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQL 305

Query: 290 LPAPEPLKLDPATAHPLLELSKGNTVVQCGLLAQRRASQ-PERFDYSTCVLASRGFSCGR 348
           +     + LDP TAHP L LS+    V+      R     P RF +  CVLA+ GF+ GR
Sbjct: 306 IA---DVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGR 362

Query: 349 HYWEVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVA 408
           HYWEV VG K+ W +GV + + SRKG+L   PE G W + L  G  Y A   P  PL + 
Sbjct: 363 HYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIK 422

Query: 409 GHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCWHERGSNSLPM 468
             P R+G++L YE G L+F++     D   +YTF   F  KL+P+          N+ P+
Sbjct: 423 VKPKRVGIFLDYEAGTLSFYNV---TDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPL 479

Query: 469 VLPPPS 474
            + PP+
Sbjct: 480 TIRPPT 485


>gi|217035095 tripartite motif-containing 62 [Homo sapiens]
          Length = 475

 Score =  219 bits (558), Expect = 4e-57
 Identities = 140/471 (29%), Positives = 222/471 (47%), Gaps = 19/471 (4%)

Query: 10  LEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAE--LRCPVCRQAVDGSSSLP 67
           L+D L C ICL ++++P+ L C H +C+ C+       +A+    CP CR+     +  P
Sbjct: 5   LKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEPALAP 64

Query: 68  NVSLARVIEALR-------LPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHH 120
           ++ LA ++E          L      + C  H + + LFC  D+ L+C  C     H+ H
Sbjct: 65  SLKLANIVERYSSFPLDAILNARRAARPCQAH-DKVKLFCLTDRALLCFFCDEPALHEQH 123

Query: 121 PVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQ 180
            VT +   +  ++ EL   +  L+  +++  E +  L        + +      I   F+
Sbjct: 124 QVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAFE 183

Query: 181 ELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQ-AQGTRERLAQAECVLEQFGNEDHHK 239
            LH L+ E +   LE +   T   +  ++ ++++ +Q  R+    A+ + E+    D H 
Sbjct: 184 RLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHT 243

Query: 240 FIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPEPLKLD 299
           F+     +AS +E  + +  E   +   F    +   ++ T+WK LF+ + P P  L LD
Sbjct: 244 FLA---GVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLD 300

Query: 300 PATAHPLLELSKGNTVVQCGLL-AQRRASQPERFDYSTCVLASRGFSCGRHYWEVVVGSK 358
           P TAH  L LS   T+V  G L  Q     P+RFD    VL S  FS G HYWEVVV  K
Sbjct: 301 PGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEK 360

Query: 359 SDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGHPHRIGLYL 418
           + W +G+    ASRKG +   P  G + I + +G  Y A   P   L V     ++G++L
Sbjct: 361 TQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFL 420

Query: 419 HYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCW-HERGSNSLPM 468
            Y+QG L F++A   DD+  LYTF+  F GKL         H  G N  P+
Sbjct: 421 DYDQGLLIFYNA---DDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPL 468


>gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]
          Length = 518

 Score =  218 bits (556), Expect = 8e-57
 Identities = 154/516 (29%), Positives = 236/516 (45%), Gaps = 66/516 (12%)

Query: 6   SLLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAVDGSSS 65
           +L  L+    C +CLE  KEP++++CGH++CK C+      L+ +  CPVCR+     S 
Sbjct: 19  ALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSL 78

Query: 66  LPNVSLARVIEALRLPGDPEPKV-----CVHHRNPLSLFCEKDQELICGLCGLLGSHQHH 120
            PN  L  ++E  +     + K+     C  H   LSLFC +DQE +C +C +  +H+ H
Sbjct: 79  RPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAH 138

Query: 121 PVTPVSTVYSRMKEELAALISELKQ-----------EQKKVDELIAKLVNNRTRIVNESD 169
            V P+       KE+L   +  L+Q           E+KK  EL   + + R +I+    
Sbjct: 139 TVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQIL---- 194

Query: 170 VFSWVIRREFQELHHLVDEEKARCLEGIG-----------------GHTRGLVASLDMQL 212
                  REF+ELH  +DEE+   L  +                  G  R  +A L  ++
Sbjct: 195 -------REFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEV 247

Query: 213 EQA--QGTRERLAQAECVLEQ-----FGNE------DHHKFIRKFHSMASRAEMPQARPL 259
           E    Q   E L   +  LE+     FG          HK +       +R E  + + +
Sbjct: 248 EGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCE--KVKTM 305

Query: 260 EGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPEPLKLDPATAHPLLELSKGNTVVQCG 319
           E     I  +        +    +++ ++++     + LDP TAHP L LS+    V+  
Sbjct: 306 EVTSVSIELEKNFSNFPRQYFALRKILKQLIA---DVTLDPETAHPNLVLSEDRKSVKFV 362

Query: 320 LLAQRRASQ-PERFDYSTCVLASRGFSCGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNR 378
               R     P RF +  CVLA+ GF+ GRHYWEV VG K+ W +GV + + SRKG+L  
Sbjct: 363 ETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTP 422

Query: 379 SPEHGVWLIGLKEGRVYEAFACPRVPLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRP 438
            PE G W + L  G  Y A   P  PL +   P R+G++L YE G L+F++     D   
Sbjct: 423 LPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNV---TDRSH 479

Query: 439 LYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPS 474
           +YTF   F  KL+P+          N+ P+ + PP+
Sbjct: 480 IYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPT 515


>gi|112421127 tripartite motif-containing 58 [Homo sapiens]
          Length = 486

 Score =  213 bits (542), Expect = 3e-55
 Identities = 151/494 (30%), Positives = 229/494 (46%), Gaps = 46/494 (9%)

Query: 1   MAWQVSLLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAE----LRCPVC 56
           MAW      L +  +CP+CL+  +EP+ + CGHS+C  C+       D        CP C
Sbjct: 1   MAWAPPGERLREDARCPVCLDFLQEPVSVDCGHSFCLRCISEFCEKSDGAQGGVYACPQC 60

Query: 57  RQAVDGSSSLPNVSLARVIEALR---LPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGL 113
           R     S   PN  LA ++E++R   L   P  + C  H   LS FCE+D+  +C +C  
Sbjct: 61  RGPFRPSGFRPNRQLAGLVESVRRLGLGAGPGARRCARHGEDLSRFCEEDEAALCWVCDA 120

Query: 114 LGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKL-VNNRTRIVNES-DVF 171
              H+ H   P+       + +L   +  +++E +  D L  +  V  +T I  E  ++ 
Sbjct: 121 GPEHRTHRTAPLQEAAGSYQVKLQMALELMRKELE--DALTQEANVGKKTVIWKEKVEMQ 178

Query: 172 SWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQ 231
               R EF++    + +E+ R L       R L A     L++ + ++ RL Q    L++
Sbjct: 179 RQRFRLEFEKHRGFLAQEEQRQL-------RRLEAEERATLQRLRESKSRLVQQSKALKE 231

Query: 232 FGNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLP 291
             +E           +  R + P    LEG    +S    + + + +    +      +P
Sbjct: 232 LADE-----------LQERCQRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIP 280

Query: 292 APEPL--------KLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRG 343
               L        KLDPATAHP L L+     VQ G   +   + PERFD   C+L  + 
Sbjct: 281 GRRELLRKFQVDVKLDPATAHPSLLLTADLRSVQDGEPWRDVPNNPERFDTWPCILGLQS 340

Query: 344 FSCGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRV 403
           FS GRHYWEV+VG  ++W LGV + T  RKG+   SPE+GVW + L +G  Y   A P V
Sbjct: 341 FSSGRHYWEVLVGEGAEWGLGVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSV 400

Query: 404 PLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCWHERGS 463
           PL     P  IG++L YE GE++F++     D   +YTF   F G L P    C      
Sbjct: 401 PLLQLESPRCIGIFLDYEAGEISFYNV---TDGSYIYTFNQLFSGLLRPYFFIC------ 451

Query: 464 NSLPMVLPPPSGPG 477
           ++ P++LPP +  G
Sbjct: 452 DATPLILPPTTIAG 465


>gi|88999601 tripartite motif-containing 69 isoform a [Homo sapiens]
          Length = 500

 Score =  210 bits (535), Expect = 2e-54
 Identities = 143/478 (29%), Positives = 220/478 (46%), Gaps = 35/478 (7%)

Query: 14  LQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAVDGSSSLPNVSLAR 73
           L CP+C + F++PLML CGH++C+ C+         E  CP C+     ++   N  L +
Sbjct: 39  LHCPLCNDWFRDPLMLSCGHNFCEACIQDFWRLQAKETFCPECKMLCQYNNCTFNPVLDK 98

Query: 74  VIEALR----LPGDPEPKVCVHHRNPLSLFCEKDQELICGLC--GLLGSHQHHPVTPVST 127
           ++E ++    L G P+   C  H   L LF + D +LIC  C    L   Q      +S 
Sbjct: 99  LVEKIKKLPLLKGHPQ---CPEHGENLKLFSKPDGKLICFQCKDARLSVGQSKEFLQISD 155

Query: 128 VYSRMKEELAALISELKQEQKKVD-------ELIAKLVNNRTRIVNESDVFSWVIRREFQ 180
                 EELA    +L+   K++        E IA    N+  +          +  EF 
Sbjct: 156 AVHFFTEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQQH-------VSMEFL 208

Query: 181 ELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQG----TRERLAQAECVLEQFGNED 236
           +LH  +  ++   L  +    + L   +++ L Q Q      ++ L   +   EQ  + D
Sbjct: 209 KLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFD 268

Query: 237 HHKFIRKF-HSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPEP 295
             K I    HS+    ++   R L           G ++  I+  VW+ +   + P   P
Sbjct: 269 FLKDITTLLHSLEQGMKVLATRELISR----KLNLGQYKGPIQYMVWREMQDTLCPGLSP 324

Query: 296 LKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYWEVVV 355
           L LDP TAHP L LSK  T V  G + +     PERFD S  VL SRGF+ G+ YWEV V
Sbjct: 325 LTLDPKTAHPNLVLSKSQTSVWHGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEV 384

Query: 356 GSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGHPHRIG 415
             K+ W +GV++ +  RKG    +PE G WL+ L+     +A   P   L +  +  ++G
Sbjct: 385 AKKTKWTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVG 444

Query: 416 LYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPP 473
           +YL YE G+L+F++A     +  +YTF   F  KLYP    C ++ G N  P+ +  P
Sbjct: 445 IYLDYEGGQLSFYNA---KTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHILHP 499


>gi|5730009 ret finger protein [Homo sapiens]
          Length = 513

 Score =  207 bits (526), Expect = 2e-53
 Identities = 142/491 (28%), Positives = 226/491 (46%), Gaps = 31/491 (6%)

Query: 10  LEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAVDGSSSLPNV 69
           L+    CP+CL+ F EP+ML CGH+ C  CL       +  + CP CR+        PN 
Sbjct: 10  LQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETFPQRHMRPNR 69

Query: 70  SLARVIEALRL-----PGDP--EPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPV 122
            LA V + ++      P  P  E  VC  HR PL L+CE+DQ  IC +C     H+ H V
Sbjct: 70  HLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSV 129

Query: 123 TPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQEL 182
            P+       KE++   +  LK+ +       A+    R  +++ + +    I  EF++L
Sbjct: 130 LPLEEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQL 189

Query: 183 HHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHKFIR 242
           +H + E + R L  +      +  S++  + Q       L+     LE+   +   + ++
Sbjct: 190 YHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTRELLQ 249

Query: 243 KFHSMASRAEMPQARPLEGAFSPISFKPGLH---QADIKLTVWKRLFRKVLPAPEP---- 295
                 SRAE  + R  E   +P   +  +H   Q  + LT   + F + + +       
Sbjct: 250 DIGDTLSRAE--RIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQE 307

Query: 296 ----------LKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFS 345
                     + LDP TA+P L LS     V+   L Q     PERF+   CVL S  F 
Sbjct: 308 LREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFI 367

Query: 346 CGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPL 405
            GRHYWEV VG K+ W +GV + +  RKG +  +P++G W + L  G+ Y A   P   L
Sbjct: 368 AGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTAL 427

Query: 406 PVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTF-QADFQGKLYPILDTCWHERGSN 464
           P+     R+G++L Y+ GE++F++     +    +TF  A F G + P      +  G +
Sbjct: 428 PLRTPLQRVGIFLDYDAGEVSFYNV---TERCHTFTFSHATFCGPVRPYFSLS-YSGGKS 483

Query: 465 SLPMVLPPPSG 475
           + P+++ P SG
Sbjct: 484 AAPLIICPMSG 494


>gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens]
          Length = 511

 Score =  200 bits (509), Expect = 2e-51
 Identities = 146/487 (29%), Positives = 224/487 (45%), Gaps = 45/487 (9%)

Query: 9   ELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLV---------SLSCHLDAE---LRCPVC 56
           EL+    C ICLE+F+EP+ ++CGHS+C+ C+          S+     A    L CP C
Sbjct: 22  ELQGEATCSICLELFREPVSVECGHSFCRACIGRCWERPGAGSVGAATRAPPFPLPCPQC 81

Query: 57  RQAVDGSSSLPNVSLARVIEALR-------LPGDPEPKV---------CVHHRNPLSLFC 100
           R+    S   PN  LA V   LR        PG+   +          C  H  P  L+C
Sbjct: 82  REPARPSQLRPNRQLAAVATLLRRFSLPAAAPGEHGSQAAAARAAAARCGQHGEPFKLYC 141

Query: 101 EKDQELICGLCGLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNN 160
           + D   IC +C     H+ H V P+       KE L + +  LK+E +  +   +     
Sbjct: 142 QDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESRLRVLKKELEDCEVFRSTEKKE 201

Query: 161 RTRIVNESDVFSWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRE 220
              ++ +       +  EFQ L   + E++ R L  +   +R +    +  L Q      
Sbjct: 202 SKELLKQMAAEQEKVGAEFQALRAFLVEQEGRLLGRLEELSREVAQKQNENLAQLGVEIT 261

Query: 221 RLAQAECVLEQFGNEDHHKFIRKFHSMASR-AEMPQARPLEGAFSPISFKPGLHQADIKL 279
           +L++    +++   +    F+++F S  SR + +P  +P   +      K  +    +K 
Sbjct: 262 QLSKLSSQIQETAQKPDLDFLQEFKSTLSRCSNVPGPKPTTVSSE---MKNKVWNVSLKT 318

Query: 280 TVWKRLFRKV-------LPAPEP--LKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPE 330
            V K + +K        L   E   L LDP TA+P L LS     V+ G  AQ   + P 
Sbjct: 319 FVLKGMLKKFKEDLRGELEKEEKVELTLDPDTANPRLILSLDLKGVRLGERAQDLPNHPC 378

Query: 331 RFDYSTCVLASRGFSCGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLK 390
           RFD +T VLAS GFS GRH+WEV VGSK  W  GV + +  RKG    +PE GVW + L 
Sbjct: 379 RFDTNTRVLASCGFSSGRHHWEVEVGSKDGWAFGVARESVRRKGLTPFTPEEGVWALQLN 438

Query: 391 EGRVYEAFACPRVPLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKL 450
            G+ +   +  R PL   GH  R+ + L  E G ++F+     +D+R LYTF+ +FQ ++
Sbjct: 439 GGQYWAVTSPERSPLS-CGHLSRVRVALDLEVGAVSFYAV---EDMRHLYTFRVNFQERV 494

Query: 451 YPILDTC 457
           +P+   C
Sbjct: 495 FPLFSVC 501


>gi|21630277 tripartite motif-containing 11 [Homo sapiens]
          Length = 468

 Score =  186 bits (471), Expect = 5e-47
 Identities = 148/484 (30%), Positives = 224/484 (46%), Gaps = 52/484 (10%)

Query: 10  LEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAVDGSSSLPNV 69
           L++   C ICL+ F +P+M  CGH++C+ C+       +    CP CR+     +  PN 
Sbjct: 10  LQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELSPQRNLRPNR 69

Query: 70  SLARVIEALRL--PGDPEPK-VCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVS 126
            LA++ E  R   P  P P+ VC  HR PL+ FC  +  L+C  C   G H  H V P+ 
Sbjct: 70  PLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEHWAHRVRPLQ 129

Query: 127 TVYSRMKEELAALISELKQE-------QKKVDE---LIAKLVNN-RTRIVNESDVFSWVI 175
                +K +L   +  L+++       Q + DE   L  K+V + R  ++ E +    ++
Sbjct: 130 DAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLGEFERLRRLL 189

Query: 176 RREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAE--CVLEQFG 233
             E Q+L   ++EE+   L  +    R   A L    +Q+    E +A+ E  C L   G
Sbjct: 190 AEEEQQLLQRLEEEELEVLPRL----REGAAHLG---QQSAHLAELIAELEGRCQLPALG 242

Query: 234 N-EDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPA 292
             +D    +R+   +  + + P+  P+E     +   PGL +         R FR     
Sbjct: 243 LLQDIKDALRRVQDV--KLQPPEVVPME--LRTVCRVPGLVET-------LRRFRG---- 287

Query: 293 PEPLKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYWE 352
              + LDP TA+P L LS+    VQ G L Q     PERFD   CVL    F+ GRHYWE
Sbjct: 288 --DVTLDPDTANPELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWE 345

Query: 353 VVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGHPH 412
           V VG ++ W LGV +   +RK K   S  +G W++ +  G  Y   +  R   P+   P 
Sbjct: 346 VEVGDRTSWALGVCRENVNRKEKGELSAGNGFWIL-VFLGSYYN--SSERALAPLRDPPR 402

Query: 413 RIGLYLHYEQGELTFFDADRPDDLRPLYTF-QADFQGKLYPILDTCWHERGSNSLPMVLP 471
           R+G++L YE G L+F+ A    D   L+ F +  F G L P+         S+  PM + 
Sbjct: 403 RVGIFLDYEAGHLSFYSA---TDGSLLFIFPEIPFSGTLRPLFSPL----SSSPTPMTIC 455

Query: 472 PPSG 475
            P G
Sbjct: 456 RPKG 459


>gi|15208660 tripartite motif protein 21 [Homo sapiens]
          Length = 475

 Score =  185 bits (469), Expect = 9e-47
 Identities = 138/480 (28%), Positives = 222/480 (46%), Gaps = 24/480 (5%)

Query: 1   MAWQVSLLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAV 60
           MA    L  + + + CPICL+ F EP+ ++CGHS+C+ C+  +         CPVCRQ  
Sbjct: 1   MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVG--KGGGSVCPVCRQRF 58

Query: 61  DGSSSLPNVSLARVIEALRLPGDP-----EPKVCVHHRNPLSLFCEKDQELICGLCGLLG 115
              +  PN  LA ++  L+          + + C  H   L LFCEKD + +C +C    
Sbjct: 59  LLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSR 118

Query: 116 SHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVI 175
            H+ H + P+       +E+L   + EL+++Q+  ++L  ++   R       +     I
Sbjct: 119 KHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRI 178

Query: 176 RREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRE-RLAQAECVLEQFGN 234
             EF +  + + EE+ R L+ +    R  +  L        G +E +LAQ    L++  +
Sbjct: 179 HAEFVQQKNFLVEEEQRQLQELEKDEREQLRIL--------GEKEAKLAQQSQALQELIS 230

Query: 235 EDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVL-PAP 293
           E      R+ HS A          LE + S       +   +++        +K+L    
Sbjct: 231 E----LDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCA 286

Query: 294 EPLKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYWEV 353
             + LDP TA+P L LS+    V+ G   Q      ERFD    VL ++ F  G+HYWEV
Sbjct: 287 VHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEV 346

Query: 354 VVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGHPHR 413
            V  K  W LGV + +  RKG    S + G W I L   + YEA   P+ PL +   P +
Sbjct: 347 DVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQ 406

Query: 414 IGLYLHYEQGELTFFDADRPDDLRPLYTF-QADFQGKLYPILDTCWHERGSNSLPMVLPP 472
           +G++L YE G ++F++      L  +Y+F +  F G L P     +++ G N+ P+ L P
Sbjct: 407 VGIFLDYEAGMVSFYNITDHGSL--IYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCP 464


>gi|37622899 ring finger protein 137 [Homo sapiens]
          Length = 485

 Score =  179 bits (453), Expect = 7e-45
 Identities = 137/477 (28%), Positives = 219/477 (45%), Gaps = 36/477 (7%)

Query: 16  CPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELR-----CPVCRQAVDGSSSLPNVS 70
           CPIC+   +EP+ + CGHS+C  CL  L   +  E +     CP+CR  V   +  PN  
Sbjct: 16  CPICMTFLREPMSIDCGHSFCHSCLSGL-WEIPGESQNWGYTCPLCRAPVQPRNLRPNWQ 74

Query: 71  LARVIEALRL----PG-DPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPV 125
           LA V+E +RL    PG   +  +C  H   L +FC++D  ++C  C     H+ H V P+
Sbjct: 75  LANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAHSVVPM 134

Query: 126 STVYSRMKEELAALISELKQEQKKVDELIA----KLVNNRTRIVNESDVFSWVIRREFQE 181
             V    K EL   +  LK+EQ++  +L      +    + ++        W    EF++
Sbjct: 135 EDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVW----EFEK 190

Query: 182 LHHLVDEEKARCLEGIGGHTRGLVASLDMQ----LEQAQGTRERLAQAECVLEQFGNEDH 237
              L+ E+K      +G      +ASL  +    +++ +     L Q   VL +   E  
Sbjct: 191 YQRLL-EKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELK 249

Query: 238 HKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPA-PEPL 296
            +  R    M    +    R    +      +P     ++K        R++L      +
Sbjct: 250 ERSQRPVRWMLQDIQEVLNRSKSWSLQ----QPEPISLELKTDCRVLGLREILKTYAADV 305

Query: 297 KLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYWEVVVG 356
           +LDP TA+  L +S+    V  G   Q+    PERF     VL S+  S GRHYWEV VG
Sbjct: 306 RLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYWEVEVG 365

Query: 357 SKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFA--CPRVPLPVAGHPHRI 414
            +S+W LGV K    RK  +  SP +G W+I L++G  Y A     P + LPV   P R+
Sbjct: 366 DRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVP--PRRV 423

Query: 415 GLYLHYEQGELTFFDADRPDDLRPLYTF-QADFQGKLYPILDTCWHERGSNSLPMVL 470
           G+++ YE  +++F++    D    ++TF +  F G+L P    C+    +N+ P+ +
Sbjct: 424 GIFVDYEAHDISFYNV--TDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAI 478


>gi|22749269 ring finger protein 129 [Homo sapiens]
          Length = 471

 Score =  170 bits (431), Expect = 2e-42
 Identities = 134/479 (27%), Positives = 212/479 (44%), Gaps = 29/479 (6%)

Query: 1   MAWQVSLLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAV 60
           M +  +L+ L++   CPICLE  K+P+ + CGH++C+ CL      LD    CPVCR   
Sbjct: 1   MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCF 60

Query: 61  DGSSSLPNVSLARVIEALRL--------PGDPEPKVCVHHRNPLSLFCEKDQELICGLCG 112
              S   N  L  + E  +             E  +C  H   L+LFC KD E++C  C 
Sbjct: 61  PYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCS 120

Query: 113 LLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFS 172
               HQ H + P+    S  +E L   +  L+   ++V+++I    +    +  + +   
Sbjct: 121 FSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKR 180

Query: 173 WVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQF 232
             I  EF+++   +  E+   L  I      ++A L+  L +       L+     L+  
Sbjct: 181 EEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVE-------LSDYVSTLKHL 233

Query: 233 GNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTV-WKRLFRKVLP 291
             E   K ++    + ++A+    +  +    P  F   L +    L   +  L R + P
Sbjct: 234 LREVEGKSVQSNLELLTQAKSMHHK-YQNLKCPELFSFRLTKYGFSLPPQYSGLDRIIKP 292

Query: 292 APEPLKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYW 351
               + LD  TAHP L +S+    V+     +     P RF     VL S+ FS GRHYW
Sbjct: 293 FQVDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYW 352

Query: 352 EVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIG--LKEGRVYEAFACPRVPLPVAG 409
           EV VG+K  W LGV +    R  +   S   G W IG  +K G V       ++ LPV  
Sbjct: 353 EVEVGNKPKWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQL-LPVV- 410

Query: 410 HPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCWHERGSNSLPM 468
            P +IG++L YE G+L+F++    +D   LYTF   F   ++P   T     G++S P+
Sbjct: 411 KPSKIGIFLDYELGDLSFYNM---NDRSILYTFNDCFTEAVWPYFYT-----GTDSEPL 461


>gi|157426898 tripartite motif-containing 10 isoform 1 [Homo
           sapiens]
          Length = 481

 Score =  170 bits (431), Expect = 2e-42
 Identities = 133/492 (27%), Positives = 214/492 (43%), Gaps = 39/492 (7%)

Query: 1   MAWQVSLLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCH-----LDAELRCPV 55
           MA   S+  L D + CPIC    +EP+ + CGH++C+ CL    C      L+    CP+
Sbjct: 1   MASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRY-CEIPGPDLEESPTCPL 59

Query: 56  CRQAVDGSSSLPNVSLARVIEAL-RLP-----GDPEPKVCVHHRNPLSLFCEKDQELICG 109
           C++     S  PN  LA V+E + RL      G  E  VC  H   +  FCE D+  +C 
Sbjct: 60  CKEPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEHGEKIYFFCEDDEMQLCV 119

Query: 110 LCGLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESD 169
           +C   G H  H +  +    +  +E++   +  L++E++++ E+ ++       ++ +  
Sbjct: 120 VCREAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQVS 179

Query: 170 VFSWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVL 229
                +  EF  L   ++E+++  L  +      ++   D       G   R +     L
Sbjct: 180 TKRQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEEL 239

Query: 230 EQFGNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQA-------------D 276
           E+       + +    S   R E  + R       P++  P L Q              +
Sbjct: 240 EEKNERPARELLTDIRSTLIRCETRKCR------KPVAVSPELGQRIRDFPQQALPLQRE 293

Query: 277 IKLTVWKRLFRKVLPAPEPLKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYST 336
           +K+ + K  F ++   P  + LDP T+HP L LS+ +   Q     Q     P+RFD +T
Sbjct: 294 MKMFLEKLCF-ELDYEPAHISLDPQTSHPKLLLSEDHQRAQFSYKWQNSPDNPQRFDRAT 352

Query: 337 CVLASRGFSCGRHYWEVVV--GSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRV 394
           CVLA  G + GRH W V +         +GV+     RKG+L   PE GVW + L  G V
Sbjct: 353 CVLAHTGITGGRHTWVVSIDLAHGGSCTVGVVSEDVQRKGELRLRPEEGVWAVRLAWGFV 412

Query: 395 YEAFACPRVPLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPIL 454
               + P   L +   P ++ + L YE G +TF +A   +   P+YTF A F  K+ P  
Sbjct: 413 SALGSFP-TRLTLKEQPRQVRVSLDYEVGWVTFTNAVTRE---PIYTFTASFTRKVIPFF 468

Query: 455 DTCWHERGSNSL 466
              W    S SL
Sbjct: 469 G-LWGRGSSFSL 479


>gi|18079262 tripartite motif-containing 6 isoform 2 [Homo sapiens]
          Length = 488

 Score =  170 bits (430), Expect = 3e-42
 Identities = 139/501 (27%), Positives = 228/501 (45%), Gaps = 52/501 (10%)

Query: 7   LLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHL----DAELRCPVCRQAVDG 62
           L+++ + + CPICLE+  EPL + CGHS+C+ C+           + E  CPVC+ +   
Sbjct: 6   LVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQP 65

Query: 63  SSSLPNVSLARVIEALRL----PGDPEPKV-CVHHRNPLSLFCEKDQELICGLCGLLGSH 117
            +  PN  LA ++  LR     PG     V C  H   L LFC++D ++IC LC     H
Sbjct: 66  GNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERSQEH 125

Query: 118 QHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRR 177
           + H    V  V    +E+    + +LK E+++ ++L A +   +T   N+ +     I+ 
Sbjct: 126 RGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQT 185

Query: 178 EFQELHHLVDEEKARCLEGI-GGHTRGL----VASLDMQLEQAQGTRERLAQAECVLEQF 232
           EF +L +++D  + R L+ +     +GL     A  D+ + Q Q  RE ++     LE+ 
Sbjct: 186 EFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDL-VHQTQSLRELISD----LERR 240

Query: 233 GNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPA 292
                 + ++    +  R+E    R  E    P   +      D+K  +  R+ R++   
Sbjct: 241 CQGSTMELLQDVSDVTERSEFWTLRKPEAL--PTKLRSMFRAPDLKRML--RVCRELTDV 296

Query: 293 PE---PLKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFD--YSTCVLASRGFSCG 347
                 + L+P TA+  L L+K    V+       + S P   +  Y   VL S+ FS G
Sbjct: 297 QSYWVDVTLNPHTANLNLVLAKNRRQVR---FVGAKVSGPSCLEKHYDCSVLGSQHFSSG 353

Query: 348 RHYWEVVVGSKSDWRLGVIKGTASRKGKLNR-----------SPEHGVWLIGLKEGRVYE 396
           +HYWEV V  K+ W LGV   +       N             P+ G W+IGL+    Y 
Sbjct: 354 KHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYR 413

Query: 397 AF--ACPRVPLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTF-QADFQGKLYPI 453
           A+  + P + L +   P R+G++L YE G ++F++        P+YTF +  F   L P 
Sbjct: 414 AYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHG--FPIYTFSKYYFPTTLCPY 471

Query: 454 LDTCWHERGSNSLPMVLPPPS 474
            + C     +  +PM L  PS
Sbjct: 472 FNPC-----NCVIPMTLRRPS 487


>gi|51477692 tripartite motif-containing 6 isoform 1 [Homo sapiens]
          Length = 516

 Score =  170 bits (430), Expect = 3e-42
 Identities = 139/501 (27%), Positives = 228/501 (45%), Gaps = 52/501 (10%)

Query: 7   LLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHL----DAELRCPVCRQAVDG 62
           L+++ + + CPICLE+  EPL + CGHS+C+ C+           + E  CPVC+ +   
Sbjct: 34  LVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQP 93

Query: 63  SSSLPNVSLARVIEALRL----PGDPEPKV-CVHHRNPLSLFCEKDQELICGLCGLLGSH 117
            +  PN  LA ++  LR     PG     V C  H   L LFC++D ++IC LC     H
Sbjct: 94  GNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERSQEH 153

Query: 118 QHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRR 177
           + H    V  V    +E+    + +LK E+++ ++L A +   +T   N+ +     I+ 
Sbjct: 154 RGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQT 213

Query: 178 EFQELHHLVDEEKARCLEGI-GGHTRGL----VASLDMQLEQAQGTRERLAQAECVLEQF 232
           EF +L +++D  + R L+ +     +GL     A  D+ + Q Q  RE ++     LE+ 
Sbjct: 214 EFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDL-VHQTQSLRELISD----LERR 268

Query: 233 GNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPA 292
                 + ++    +  R+E    R  E    P   +      D+K  +  R+ R++   
Sbjct: 269 CQGSTMELLQDVSDVTERSEFWTLRKPEAL--PTKLRSMFRAPDLKRML--RVCRELTDV 324

Query: 293 PE---PLKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFD--YSTCVLASRGFSCG 347
                 + L+P TA+  L L+K    V+       + S P   +  Y   VL S+ FS G
Sbjct: 325 QSYWVDVTLNPHTANLNLVLAKNRRQVR---FVGAKVSGPSCLEKHYDCSVLGSQHFSSG 381

Query: 348 RHYWEVVVGSKSDWRLGVIKGTASRKGKLNR-----------SPEHGVWLIGLKEGRVYE 396
           +HYWEV V  K+ W LGV   +       N             P+ G W+IGL+    Y 
Sbjct: 382 KHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYR 441

Query: 397 AF--ACPRVPLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTF-QADFQGKLYPI 453
           A+  + P + L +   P R+G++L YE G ++F++        P+YTF +  F   L P 
Sbjct: 442 AYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHG--FPIYTFSKYYFPTTLCPY 499

Query: 454 LDTCWHERGSNSLPMVLPPPS 474
            + C     +  +PM L  PS
Sbjct: 500 FNPC-----NCVIPMTLRRPS 515


>gi|14719418 tripartite motif protein TRIM5 isoform alpha [Homo
           sapiens]
          Length = 493

 Score =  162 bits (411), Expect = 5e-40
 Identities = 135/499 (27%), Positives = 224/499 (44%), Gaps = 43/499 (8%)

Query: 7   LLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVS--LSCHLD-AELRCPVCRQAVDGS 63
           L+ +++ + CPICLE+  +PL L CGHS+C+ CL +      LD  E  CPVCR +    
Sbjct: 6   LVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKKSMLDKGESSCPVCRISYQPE 65

Query: 64  SSLPNVSLARVIEALR----LPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQH 119
           +  PN  +A ++E LR     P   +   C  H   L LFC++D ++IC LC     H+ 
Sbjct: 66  NIRPNRHVANLVEKLREVKLSPEGQKVDHCARHGEKLLLFCQEDGKVICWLCERSQEHRG 125

Query: 120 HPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREF 179
           H   P   V    + +L A +  L+Q+Q++ +EL A +   +     +       +  +F
Sbjct: 126 HHTFPTEEVAQEYQVKLQAALEMLRQKQQEAEELEADIREEKASWKTQIQYDKTNVLADF 185

Query: 180 QELHHLVDEEKARCLEGIGGHTRGLVASL----DMQLEQAQGTRERLAQAE-----CVLE 230
           ++L  ++D E++  L+ +      ++ SL       ++Q Q  RE ++  E      V+E
Sbjct: 186 EQLRDILDWEESNELQNLEKEEEDILKSLTNSETEMVQQTQSLRELISDLEHRLQGSVME 245

Query: 231 QFGNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVL 290
                D    I++  ++  +      +     F     K G+ +   +LT  +R +  V 
Sbjct: 246 LLQGVD--GVIKRTENVTLKKPETFPKNQRRVFRAPDLK-GMLEVFRELTDVRRYWVDVT 302

Query: 291 PAPEPLKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHY 350
            AP  +      +    ++S     +  G    R  +    F+Y T +L S+  + G+HY
Sbjct: 303 VAPNNISC-AVISEDKRQVSSPKPQIIYGARGTRYQTF-VNFNYCTGILGSQSITSGKHY 360

Query: 351 WEVVVGSKSDWRLGVIKG-----TASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPR--- 402
           WEV V  K+ W LGV  G       + +   N  P++G W+IGL+EG    AF       
Sbjct: 361 WEVDVSKKTAWILGVCAGFQPDAMCNIEKNENYQPKYGYWVIGLEEGVKCSAFQDSSFHT 420

Query: 403 ------VPLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTF-QADFQGKLYPILD 455
                 VPL V   P R+G++L YE   ++FF+      L  +Y F    F   ++P L+
Sbjct: 421 PSVPFIVPLSVIICPDRVGVFLDYEACTVSFFNITNHGFL--IYKFSHCSFSQPVFPYLN 478

Query: 456 TCWHERGSNSLPMVLPPPS 474
                     +PM L  PS
Sbjct: 479 P-----RKCGVPMTLCSPS 492


>gi|94536782 tripartite motif-containing 35 isoform 2 [Homo sapiens]
          Length = 493

 Score =  159 bits (401), Expect = 7e-39
 Identities = 137/469 (29%), Positives = 202/469 (43%), Gaps = 55/469 (11%)

Query: 14  LQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAVDGSSSLPNVSLAR 73
           L C +C + F++ + L+CGH++C+GC VS    +     CPVC+     +    N +L  
Sbjct: 19  LLCAVCYDPFRDAVTLRCGHNFCRGC-VSRCWEVQVSPTCPVCKDRASPADLRTNHTLNN 77

Query: 74  VIEAL--------RLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPV 125
           ++E L        R       +VC  HR  LSLFC +D+EL+C  C     HQ H V PV
Sbjct: 78  LVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLCCSCQADPRHQGHRVQPV 137

Query: 126 STVYSRMKEELAALISELKQEQK------KVDELIAKLVNNRTRIVNESDVFSWVIRREF 179
                  + +   +   L+++ K      +  E IAK  +N+     E+      IR+EF
Sbjct: 138 KDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAK--HNQV----EAAWLEGRIRQEF 191

Query: 180 QELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHK 239
            +L   +  E+   L+ +   TR      D +++Q     E LA     L+    ED   
Sbjct: 192 DKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIERLQMEMKEDDVS 251

Query: 240 FIRKFHSMASRAEMPQARPLEGAFSPISFKPGL------HQADIKLTVWKRLFRKVLPAP 293
           F+ K  S        + R L     P   +PG+      +   ++  VWK++   V   P
Sbjct: 252 FLMKHKS--------RKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVESVP 303

Query: 294 EPLKLDPATAHPLLELSKGNT-VVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYWE 352
                DP TA   L +S   T V   G   Q     PERF  + C+L SR FS G H WE
Sbjct: 304 --FSFDPNTAAGWLSVSDDLTSVTNHGYRVQ--VENPERFSSAPCLLGSRVFSQGSHAWE 359

Query: 353 VVVGSKSDWRLGVIK-----GTASRKGKLNRSPEHGVWLIGLKEGRVYEAFAC----PRV 403
           V +G    WR+GV++     G              G W +   +G   E   C    P  
Sbjct: 360 VALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQG--VEGDHCVTSDPAT 417

Query: 404 PLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYP 452
              V   P R+ + L  E+GEL+F+DA+R      LYTF A F G++ P
Sbjct: 418 SPLVLAIPRRLRVELECEEGELSFYDAERHCH---LYTFHARF-GEVRP 462


>gi|31542779 tripartite motif family-like 1 [Homo sapiens]
          Length = 468

 Score =  157 bits (398), Expect = 2e-38
 Identities = 130/474 (27%), Positives = 215/474 (45%), Gaps = 35/474 (7%)

Query: 10  LEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAVDGSSSLPN- 68
           L + L C ICL+ F  P+  +CGHS+C  CL+      +  L CP C + ++G     N 
Sbjct: 10  LREELTCFICLDYFSSPVTTECGHSFCLVCLLRSWEEHNTPLSCPECWRTLEGPHFQSNE 69

Query: 69  -----VSLARVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVT 123
                 S+AR + +  L  + E     + R P +     D E   G   +  SH  + V 
Sbjct: 70  RLGRLASIARQLRSQVLQSEDEQGS--YGRMPTTAKALSDDEQ-GGSAFVAQSHGANRVH 126

Query: 124 PVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQELH 183
             S      +E+L  +++ L+  +K+   ++            E+     V+  E+ ++H
Sbjct: 127 LSSEAEEHHREKLQEILNLLRVRRKEAQAVLTHEKERVKLCQEETKTCKQVVVSEYMKMH 186

Query: 184 HLVDEEKARCLEGIGGHTRGLVASL-DMQLEQAQGTRERLAQAECVLEQFGNEDHHKFIR 242
             + EE+   L+ +    +  +  L + +++  Q  R  L++    +E        + + 
Sbjct: 187 QFLKEEEQLQLQLLEQEEKENMRKLRNNEIKLTQQIRS-LSKMIAQIESSSQSSAFESLE 245

Query: 243 KFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPEPLKLDPAT 302
           +      R+E    +  E   + +S          ++T  K + RK       + LDPAT
Sbjct: 246 EVRGALERSEPLLLQCPEATTTELSL--------CRITGMKEMLRKF---STEITLDPAT 294

Query: 303 AHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYWEVVVGSKSDWR 362
           A+  L LS+    V+ G   Q+    PERFD S  VL ++ F+ GRHYWEV VG+K++W 
Sbjct: 295 ANAYLVLSEDLKSVKYGGSRQQLPDNPERFDQSATVLGTQIFTSGRHYWEVEVGNKTEWE 354

Query: 363 LGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGHPHR-----IGLY 417
           +G+ K + SRKG L + P     LIGLK G  Y  +    V  P+ G   R     +G++
Sbjct: 355 VGICKDSVSRKGNLPKPPGDLFSLIGLKIGDDYSLW----VSSPLKGQHVREPVCKVGVF 410

Query: 418 LHYEQGELTFFDADRPDDLRPLYTF-QADFQGKLYPILDTCWHERGSNSLPMVL 470
           L YE G + F++     D   +Y+F QA FQ  L PI   C    G+N+ P+ +
Sbjct: 411 LDYESGHIAFYNG---TDESLIYSFPQASFQEALRPIFSPCLPNEGTNTDPLTI 461


>gi|42516572 tripartite motif-containing 41 isoform 1 [Homo sapiens]
          Length = 630

 Score =  157 bits (396), Expect = 3e-38
 Identities = 126/442 (28%), Positives = 188/442 (42%), Gaps = 58/442 (13%)

Query: 53  CPVCRQAVDGSSSLPNVSLARVIEALR----LPGD----PEPKVCVHHRNPLSLFCEKDQ 104
           CP CR++    S  PN+ LA +++ +R     PG      +  +C  H+  L LFCE D+
Sbjct: 183 CPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALKLFCEVDE 242

Query: 105 ELICGLCGLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRI 164
           E IC +C    SH+ H V P+  V    K +L   +  L++  + V ++ AK     T +
Sbjct: 243 EAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTEL 302

Query: 165 VNESDVFSWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQ 224
            ++       +  EF  L   + EE+A       G  R L    + QL +A     RLA+
Sbjct: 303 KSQMKSELAAVASEFGRLTRFLAEEQA-------GLERRLREMHEAQLGRAGAAASRLAE 355

Query: 225 AECVLEQFGNEDHHK-------FIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQ--A 275
               L +   E   +        ++      +R E  Q +P E  +SP   +P  H    
Sbjct: 356 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPE-VWSPDPCQPHSHDFLT 414

Query: 276 DIKLTVWKRLFRKVLPAPEPLKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYS 335
           D  +    R+F +   A   L LDP TAHP L LS     V+     Q  A  P+RF   
Sbjct: 415 DAIVRKMSRMFCQA--ARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSAD 472

Query: 336 TCVLASRGFSCGRHYWEVVVGSKSDWRLGVIKGTASRKGK-------------------- 375
            CVL ++GF  GRHYWEV VG +  W +G  + +   K K                    
Sbjct: 473 CCVLGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHH 532

Query: 376 ------LNRSP--EHGVWLIGLKEGRVYEAFACPRVPLPVAGHPHRIGLYLHYEQGELTF 427
                 L + P  +  VW +G    R     +  +  L  +  P R G+YL YE G L F
Sbjct: 533 RRRRLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGF 592

Query: 428 FDADRPDDLRPLYTFQADFQGK 449
           ++A   + L  ++TF A F G+
Sbjct: 593 YNA---ETLAHVHTFSAAFLGE 611



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 17/49 (34%), Positives = 29/49 (59%)

Query: 10 LEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQ 58
          L++   C ICL+ F +P+ + CGH++C+ C+  L    D E R  + R+
Sbjct: 14 LQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDEEDRDELDRE 62


>gi|37595541 tripartite motif-containing 69 isoform b [Homo sapiens]
          Length = 341

 Score =  156 bits (395), Expect = 4e-38
 Identities = 107/354 (30%), Positives = 165/354 (46%), Gaps = 26/354 (7%)

Query: 132 MKEELAALISELKQEQKKVD-------ELIAKLVNNRTRIVNESDVFSWVIRREFQELHH 184
           M+EELA    +L+   K++        E IA    N+  +          +  EF +LH 
Sbjct: 1   MEEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQQH-------VSMEFLKLHQ 53

Query: 185 LVDEEKARCLEGIGGHTRGLVASLDMQLEQAQG----TRERLAQAECVLEQFGNEDHHKF 240
            +  ++   L  +    + L   +++ L Q Q      ++ L   +   EQ  + D  K 
Sbjct: 54  FLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKD 113

Query: 241 IRKF-HSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPEPLKLD 299
           I    HS+    ++   R L           G ++  I+  VW+ +   + P   PL LD
Sbjct: 114 ITTLLHSLEQGMKVLATRELISR----KLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLD 169

Query: 300 PATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYWEVVVGSKS 359
           P TAHP L LSK  T V  G + +     PERFD S  VL SRGF+ G+ YWEV V  K+
Sbjct: 170 PKTAHPNLVLSKSQTSVWHGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKT 229

Query: 360 DWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGHPHRIGLYLH 419
            W +GV++ +  RKG    +PE G WL+ L+     +A   P   L +  +  ++G+YL 
Sbjct: 230 KWTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLD 289

Query: 420 YEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPP 473
           YE G+L+F++A     +  +YTF   F  KLYP    C ++ G N  P+ +  P
Sbjct: 290 YEGGQLSFYNA---KTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHILHP 340


>gi|68160933 tripartite motif-containing 17 isoform 1 [Homo sapiens]
          Length = 477

 Score =  154 bits (389), Expect = 2e-37
 Identities = 133/475 (28%), Positives = 202/475 (42%), Gaps = 60/475 (12%)

Query: 9   ELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHL----------DAELRCPVCRQ 58
           +L++   C ICL+ F +P+M  CGH++C+ C + LS                  CP CR+
Sbjct: 9   KLQEEATCSICLDYFTDPVMTTCGHNFCRAC-IQLSWEKARGKKGRRKRKGSFPCPECRE 67

Query: 59  AVDGSSSLPNVSLARVIE-ALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSH 117
                + LPN  L +V E A + PG  +  +C  H  PL LFC+KDQ  IC +C     H
Sbjct: 68  MSPQRNLLPNRLLTKVAEMAQQHPGLQKQDLCQEHHEPLKLFCQKDQSPICVVCRESREH 127

Query: 118 QHHPVTPVSTVYSRMKEELAALISELKQ-----------EQKKVDELIAKLVNNRTRIVN 166
           + H V P        K +L   +  L++           E++ + E   K+   R RIV 
Sbjct: 128 RLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERIVL 187

Query: 167 ESDVFSWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQ----GTRERL 222
           E +  +  +  E Q L   ++ E+    E      R  VA LD Q    +       ER 
Sbjct: 188 EFEKMNLYLVEEEQRLLQALETEE----EETASRLRESVACLDRQGHSLELLLLQLEERS 243

Query: 223 AQAECVLEQFGNEDHHKFIRKFHSMASRAEM-PQARPLEGAFSPISFKPGLHQADIKLTV 281
            Q    + Q   E      RK +      E+ P  RP       +   PG      ++ V
Sbjct: 244 TQGPLQMLQDMKEP---LSRKNNVSVQCPEVAPPTRP-----RTVCRVPG------QIEV 289

Query: 282 WKRLFRKVLPAPEPLKLDPATAHPLLELSKGNTVVQCGLLAQRRA-SQPERFDYSTCVLA 340
            +     V+P       D  +A+P L L +       G   +       +RF    C + 
Sbjct: 290 LRGFLEDVVP-------DATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVG 342

Query: 341 SRGFSCGRHYWEVVVGSKSD--WRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAF 398
              FS GRHYWEV +    D  W LGV +   SRK ++ + PE+G W++ L +G  Y + 
Sbjct: 343 QTAFSSGRHYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLST 402

Query: 399 ACPRVPLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTF-QADFQGKLYP 452
                P+ +   P  +G++L +E GE++F+      D   L+T+ QA F G L P
Sbjct: 403 FSALTPVMLMEPPSHMGIFLDFEAGEVSFYSV---SDGSHLHTYSQATFPGPLQP 454


>gi|7705825 tripartite motif-containing 17 isoform 1 [Homo sapiens]
          Length = 477

 Score =  154 bits (389), Expect = 2e-37
 Identities = 133/475 (28%), Positives = 202/475 (42%), Gaps = 60/475 (12%)

Query: 9   ELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHL----------DAELRCPVCRQ 58
           +L++   C ICL+ F +P+M  CGH++C+ C + LS                  CP CR+
Sbjct: 9   KLQEEATCSICLDYFTDPVMTTCGHNFCRAC-IQLSWEKARGKKGRRKRKGSFPCPECRE 67

Query: 59  AVDGSSSLPNVSLARVIE-ALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSH 117
                + LPN  L +V E A + PG  +  +C  H  PL LFC+KDQ  IC +C     H
Sbjct: 68  MSPQRNLLPNRLLTKVAEMAQQHPGLQKQDLCQEHHEPLKLFCQKDQSPICVVCRESREH 127

Query: 118 QHHPVTPVSTVYSRMKEELAALISELKQ-----------EQKKVDELIAKLVNNRTRIVN 166
           + H V P        K +L   +  L++           E++ + E   K+   R RIV 
Sbjct: 128 RLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERIVL 187

Query: 167 ESDVFSWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQ----GTRERL 222
           E +  +  +  E Q L   ++ E+    E      R  VA LD Q    +       ER 
Sbjct: 188 EFEKMNLYLVEEEQRLLQALETEE----EETASRLRESVACLDRQGHSLELLLLQLEERS 243

Query: 223 AQAECVLEQFGNEDHHKFIRKFHSMASRAEM-PQARPLEGAFSPISFKPGLHQADIKLTV 281
            Q    + Q   E      RK +      E+ P  RP       +   PG      ++ V
Sbjct: 244 TQGPLQMLQDMKEP---LSRKNNVSVQCPEVAPPTRP-----RTVCRVPG------QIEV 289

Query: 282 WKRLFRKVLPAPEPLKLDPATAHPLLELSKGNTVVQCGLLAQRRA-SQPERFDYSTCVLA 340
            +     V+P       D  +A+P L L +       G   +       +RF    C + 
Sbjct: 290 LRGFLEDVVP-------DATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVG 342

Query: 341 SRGFSCGRHYWEVVVGSKSD--WRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAF 398
              FS GRHYWEV +    D  W LGV +   SRK ++ + PE+G W++ L +G  Y + 
Sbjct: 343 QTAFSSGRHYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLST 402

Query: 399 ACPRVPLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTF-QADFQGKLYP 452
                P+ +   P  +G++L +E GE++F+      D   L+T+ QA F G L P
Sbjct: 403 FSALTPVMLMEPPSHMGIFLDFEAGEVSFYSV---SDGSHLHTYSQATFPGPLQP 454


>gi|51477687 tripartite motif protein 34 isoform 1 [Homo sapiens]
          Length = 488

 Score =  151 bits (381), Expect = 1e-36
 Identities = 145/525 (27%), Positives = 225/525 (42%), Gaps = 100/525 (19%)

Query: 7   LLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLS----CHLDAELRCPVCRQAVDG 62
           LL +++ + CPICLE+  EPL L CGHS C+ C+   +      +  +  CPVC  +   
Sbjct: 6   LLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSF 65

Query: 63  SSSLPNVSLARVIEALR---LPGDPEPK--VCVHHRNPLSLFCEKDQELICGLCGLLGSH 117
                N  LA ++E L+   L  D   K  +C HH   L LFC++D+++IC LC     H
Sbjct: 66  EHLQANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICWLCERSQEH 125

Query: 118 QHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRR 177
           + H       V+   +E+L A++  LK+E+++ ++L A +   +T    +       I+ 
Sbjct: 126 RGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQRIQT 185

Query: 178 EFQELHHLVDEEKARCLEGIGGHTRGLVASL----DMQLEQAQGTRERLAQAECVLEQFG 233
           EF +L  +++ E+ R L+ +    +  +       D  ++Q Q  RE ++  EC      
Sbjct: 186 EFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVEC------ 239

Query: 234 NEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAP 293
                       S  S  E+ Q   + G                 +  W  ++R   P  
Sbjct: 240 -----------RSQWSTMELLQ--DMSG-----------------IMKWSEIWRLKKPKM 269

Query: 294 EPLKLDPATAHP----LLELSKGNTVVQC----------GLLAQRRASQPER-------- 331
              KL      P    +L++ +  T V+C           L      S+ +R        
Sbjct: 270 VSKKLKTVFHAPDLSRMLQMFRELTAVRCYWVDVTLNSVNLNLNLVLSEDQRQVISVPIW 329

Query: 332 -FD-YSTCVLASRGFSCGRHYWEVVVGSKSDWRLGVIKGTASRKGK------LNRS---- 379
            F  Y+  VL S+ FS G+HYWEV V  K+ W LGV   T SR  K       NR     
Sbjct: 330 PFQCYNYGVLGSQYFSSGKHYWEVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYT 389

Query: 380 ---PEHGVWLIGLKEGRVYEAF-----ACPRV-PLPVAGHPHRIGLYLHYEQGELTFFDA 430
              P  G W+IGL+    Y  F     + P V  L +A  P R+G++L YE G ++FF+ 
Sbjct: 390 KYRPLFGYWVIGLQNKCKYGVFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNV 449

Query: 431 DRPDDLRPLYTF-QADFQGKLYPILDTCWHERGSNSLPMVLPPPS 474
                L  +Y F +  F   +YP  +  W    +   PM L PPS
Sbjct: 450 TSHGSL--IYKFSKCCFSQPVYPYFNP-W----NCPAPMTLCPPS 487


>gi|18087807 tripartite motif protein 34 isoform 1 [Homo sapiens]
          Length = 488

 Score =  151 bits (381), Expect = 1e-36
 Identities = 145/525 (27%), Positives = 225/525 (42%), Gaps = 100/525 (19%)

Query: 7   LLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLS----CHLDAELRCPVCRQAVDG 62
           LL +++ + CPICLE+  EPL L CGHS C+ C+   +      +  +  CPVC  +   
Sbjct: 6   LLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSF 65

Query: 63  SSSLPNVSLARVIEALR---LPGDPEPK--VCVHHRNPLSLFCEKDQELICGLCGLLGSH 117
                N  LA ++E L+   L  D   K  +C HH   L LFC++D+++IC LC     H
Sbjct: 66  EHLQANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICWLCERSQEH 125

Query: 118 QHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRR 177
           + H       V+   +E+L A++  LK+E+++ ++L A +   +T    +       I+ 
Sbjct: 126 RGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQRIQT 185

Query: 178 EFQELHHLVDEEKARCLEGIGGHTRGLVASL----DMQLEQAQGTRERLAQAECVLEQFG 233
           EF +L  +++ E+ R L+ +    +  +       D  ++Q Q  RE ++  EC      
Sbjct: 186 EFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVEC------ 239

Query: 234 NEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAP 293
                       S  S  E+ Q   + G                 +  W  ++R   P  
Sbjct: 240 -----------RSQWSTMELLQ--DMSG-----------------IMKWSEIWRLKKPKM 269

Query: 294 EPLKLDPATAHP----LLELSKGNTVVQC----------GLLAQRRASQPER-------- 331
              KL      P    +L++ +  T V+C           L      S+ +R        
Sbjct: 270 VSKKLKTVFHAPDLSRMLQMFRELTAVRCYWVDVTLNSVNLNLNLVLSEDQRQVISVPIW 329

Query: 332 -FD-YSTCVLASRGFSCGRHYWEVVVGSKSDWRLGVIKGTASRKGK------LNRS---- 379
            F  Y+  VL S+ FS G+HYWEV V  K+ W LGV   T SR  K       NR     
Sbjct: 330 PFQCYNYGVLGSQYFSSGKHYWEVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYT 389

Query: 380 ---PEHGVWLIGLKEGRVYEAF-----ACPRV-PLPVAGHPHRIGLYLHYEQGELTFFDA 430
              P  G W+IGL+    Y  F     + P V  L +A  P R+G++L YE G ++FF+ 
Sbjct: 390 KYRPLFGYWVIGLQNKCKYGVFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNV 449

Query: 431 DRPDDLRPLYTF-QADFQGKLYPILDTCWHERGSNSLPMVLPPPS 474
                L  +Y F +  F   +YP  +  W    +   PM L PPS
Sbjct: 450 TSHGSL--IYKFSKCCFSQPVYPYFNP-W----NCPAPMTLCPPS 487


>gi|51477690 tripartite motif-containing 6 and tripartite
           motif-containing 34 [Homo sapiens]
          Length = 842

 Score =  151 bits (381), Expect = 1e-36
 Identities = 145/525 (27%), Positives = 225/525 (42%), Gaps = 100/525 (19%)

Query: 7   LLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLS----CHLDAELRCPVCRQAVDG 62
           LL +++ + CPICLE+  EPL L CGHS C+ C+   +      +  +  CPVC  +   
Sbjct: 360 LLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSF 419

Query: 63  SSSLPNVSLARVIEALR---LPGDPEPK--VCVHHRNPLSLFCEKDQELICGLCGLLGSH 117
                N  LA ++E L+   L  D   K  +C HH   L LFC++D+++IC LC     H
Sbjct: 420 EHLQANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICWLCERSQEH 479

Query: 118 QHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRR 177
           + H       V+   +E+L A++  LK+E+++ ++L A +   +T    +       I+ 
Sbjct: 480 RGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQRIQT 539

Query: 178 EFQELHHLVDEEKARCLEGIGGHTRGLVASL----DMQLEQAQGTRERLAQAECVLEQFG 233
           EF +L  +++ E+ R L+ +    +  +       D  ++Q Q  RE ++  EC      
Sbjct: 540 EFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVEC------ 593

Query: 234 NEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAP 293
                       S  S  E+ Q   + G                 +  W  ++R   P  
Sbjct: 594 -----------RSQWSTMELLQ--DMSG-----------------IMKWSEIWRLKKPKM 623

Query: 294 EPLKLDPATAHP----LLELSKGNTVVQC----------GLLAQRRASQPER-------- 331
              KL      P    +L++ +  T V+C           L      S+ +R        
Sbjct: 624 VSKKLKTVFHAPDLSRMLQMFRELTAVRCYWVDVTLNSVNLNLNLVLSEDQRQVISVPIW 683

Query: 332 -FD-YSTCVLASRGFSCGRHYWEVVVGSKSDWRLGVIKGTASRKGK------LNRS---- 379
            F  Y+  VL S+ FS G+HYWEV V  K+ W LGV   T SR  K       NR     
Sbjct: 684 PFQCYNYGVLGSQYFSSGKHYWEVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYT 743

Query: 380 ---PEHGVWLIGLKEGRVYEAF-----ACPRV-PLPVAGHPHRIGLYLHYEQGELTFFDA 430
              P  G W+IGL+    Y  F     + P V  L +A  P R+G++L YE G ++FF+ 
Sbjct: 744 KYRPLFGYWVIGLQNKCKYGVFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNV 803

Query: 431 DRPDDLRPLYTF-QADFQGKLYPILDTCWHERGSNSLPMVLPPPS 474
                L  +Y F +  F   +YP  +  W    +   PM L PPS
Sbjct: 804 TSHGSL--IYKFSKCCFSQPVYPYFNP-W----NCPAPMTLCPPS 841



 Score =  107 bits (266), Expect = 3e-23
 Identities = 60/198 (30%), Positives = 101/198 (51%), Gaps = 9/198 (4%)

Query: 7   LLELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHL----DAELRCPVCRQAVDG 62
           L+++ + + CPICLE+  EPL + CGHS+C+ C+           + E  CPVC+ +   
Sbjct: 34  LVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQP 93

Query: 63  SSSLPNVSLARVIEALRL----PGDPEPKV-CVHHRNPLSLFCEKDQELICGLCGLLGSH 117
            +  PN  LA ++  LR     PG     V C  H   L LFC++D ++IC LC     H
Sbjct: 94  GNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERSQEH 153

Query: 118 QHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRR 177
           + H    V  V    +E+    + +LK E+++ ++L A +   +T   N+ +     I+ 
Sbjct: 154 RGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQT 213

Query: 178 EFQELHHLVDEEKARCLE 195
           EF +L +++D  + R L+
Sbjct: 214 EFNQLRNILDRVEQRELK 231


>gi|117938316 tripartite motif-containing 22 [Homo sapiens]
          Length = 498

 Score =  150 bits (379), Expect = 3e-36
 Identities = 140/507 (27%), Positives = 229/507 (45%), Gaps = 56/507 (11%)

Query: 8   LELEDWLQCPICLEVFKEPLMLQCGHSYCKGCL---VSLSCHLD-AELRCPVCRQAVDGS 63
           +++E  + CPICLE+  EPL L CGHS+C+ C+   +  S  +   E  CPVC+      
Sbjct: 7   VDIEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIKESVIISRGESSCPVCQTRFQPG 66

Query: 64  SSLPNVSLARVIEALR----LPGDPEPK-VCVHHRNPLSLFCEKDQELICGLCGLLGSHQ 118
           +  PN  LA ++E ++     P + + + VC HH   L +FC++D ++IC +C L   HQ
Sbjct: 67  NLRPNRHLANIVERVKEVKMSPQEGQKRDVCEHHGKKLQIFCKEDGKVICWVCELSQEHQ 126

Query: 119 HHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRRE 178
            H    ++ V    +E+L   +  L +E ++ ++L   +   RT   N   +    I + 
Sbjct: 127 GHQTFRINEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKNYIQIERQKILKG 186

Query: 179 FQELHHLVDEEKARCL----EGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGN 234
           F E+  ++D E+ R L    EG       L A+ D  ++Q Q     ++  +  L     
Sbjct: 187 FNEMRVILDNEEQRELQKLEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQRRLRGSSV 246

Query: 235 E---DHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLP 291
           E   D    +++  S   +     ++ L+  F  +    G+ Q   +LT  +  +  V+ 
Sbjct: 247 EMLQDVIDVMKRSESWTLKKPKSVSKKLKSVFR-VPDLSGMLQVLKELTDVQYYWVDVM- 304

Query: 292 APEPLKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYW 351
                 L+P +A   + +S     V+       + S P  F  +  V   + FS G++YW
Sbjct: 305 ------LNPGSATSNVAISVDQRQVKTVRTCTFKNSNPCDFS-AFGVFGCQYFSSGKYYW 357

Query: 352 EVVVGSKSDWRLGV---IKGTASRKG-------KLNRS-------PEHGVWLIGLKEGRV 394
           EV V  K  W LGV   I     RK         +N S       P++G W+IGL+    
Sbjct: 358 EVDVSGKIAWILGVHSKISSLNKRKSSGFAFDPSVNYSKVYSRYRPQYGYWVIGLQNTCE 417

Query: 395 YEAF-----ACPRV-PLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQ-ADFQ 447
           Y AF     + P+V  L +A  P RIG++L YE G ++FF+      L  +Y F    F 
Sbjct: 418 YNAFEDSSSSDPKVLTLFMAVPPCRIGVFLDYEAGIVSFFNVTNHGAL--IYKFSGCRFS 475

Query: 448 GKLYPILDTCWHERGSNSLPMVLPPPS 474
              YP  +  W    +  +PM + PPS
Sbjct: 476 RPAYPYFNP-W----NCLVPMTVCPPS 497


>gi|15011941 tripartite motif protein TRIM4 isoform beta [Homo
           sapiens]
          Length = 474

 Score =  149 bits (375), Expect = 7e-36
 Identities = 116/468 (24%), Positives = 194/468 (41%), Gaps = 41/468 (8%)

Query: 9   ELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAVDGSSSLPN 68
           ++++ L CPICL+ F++P+ ++CGH++C+GCL            CP CR     ++  PN
Sbjct: 5   DIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPSAPAALRPN 64

Query: 69  VSLARVIEAL--RLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVS 126
            +LAR+ E    R  G   P +C  H  PL LFCE DQ  +C +C     HQ H + P+ 
Sbjct: 65  WALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQEHQTHAMAPID 124

Query: 127 TVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQELHHLV 186
             +   +E+L      L  + KKV  L    V N T+  ++       I  EF +LH+ +
Sbjct: 125 EAFESYREKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKSQRMRISTEFSKLHNFL 184

Query: 187 DEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHKFIRKFHS 246
            EE+   L+ +          L+   E      + +A  + ++ + G +     +    +
Sbjct: 185 VEEEDLFLQRLNKEEEETKKKLN---ENTLKLNQTIASLKKLILEVGEKSQAPTLELLQN 241

Query: 247 MASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPEPLKLDPATAHPL 306
                   + + +  +   +  K        ++ + K + ++   A   + L   TAHP 
Sbjct: 242 PKEVLTRSEIQDVNYSLEAVKVK-----TVCQIPLMKEMLKRFQVA---VNLAEDTAHPK 293

Query: 307 LELSKGNTVVQ------------------CGLLAQRRASQPERFDYSTCVLASRGFSCGR 348
           L  S+    V+                   G    ++ +  ERF +  CVL    F+ G+
Sbjct: 294 LVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCVLGKNVFTSGK 353

Query: 349 HYWEVVVGSKSDWRLGV----IKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVP 404
           HYWEV      +  +GV    + G   R      SP+ G+W I       +     P  P
Sbjct: 354 HYWEVESRDSLEVAVGVCREDVMGITDRS---KMSPDVGIWAIYWSAAGYWPLIGFPGTP 410

Query: 405 LPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYP 452
                  HR+G+YL    G ++F+ A    D   L+TF      +L P
Sbjct: 411 TQQEPALHRVGVYLDRGTGNVSFYSA---VDGVHLHTFSCSSVSRLRP 455


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,012,906
Number of Sequences: 37866
Number of extensions: 1118930
Number of successful extensions: 5257
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 250
Number of HSP's successfully gapped in prelim test: 141
Number of HSP's that attempted gapping in prelim test: 4441
Number of HSP's gapped (non-prelim): 566
length of query: 487
length of database: 18,247,518
effective HSP length: 106
effective length of query: 381
effective length of database: 14,233,722
effective search space: 5423048082
effective search space used: 5423048082
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.