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Search of human proteins with 12232397
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
(748 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 1560 0.0
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 1160 0.0
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 1146 0.0
gi|222352183 neural precursor cell expressed, developmentally do... 509 e-144
gi|21361472 neural precursor cell expressed, developmentally dow... 509 e-144
gi|222352094 neural precursor cell expressed, developmentally do... 509 e-144
gi|222352092 neural precursor cell expressed, developmentally do... 509 e-144
gi|222352090 neural precursor cell expressed, developmentally do... 509 e-144
gi|222352088 neural precursor cell expressed, developmentally do... 509 e-144
gi|222352086 neural precursor cell expressed, developmentally do... 509 e-144
gi|222352084 neural precursor cell expressed, developmentally do... 509 e-144
gi|222352082 neural precursor cell expressed, developmentally do... 509 e-144
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 491 e-138
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 489 e-138
gi|114520609 neural precursor cell expressed, developmentally do... 486 e-137
gi|114520607 neural precursor cell expressed, developmentally do... 486 e-137
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 484 e-136
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 432 e-121
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 363 e-100
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 359 6e-99
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 332 6e-91
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 266 5e-71
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 194 3e-49
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 193 6e-49
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 193 6e-49
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 193 6e-49
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 183 4e-46
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 176 5e-44
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 176 5e-44
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 169 7e-42
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 1560 bits (4039), Expect = 0.0
Identities = 748/748 (100%), Positives = 748/748 (100%)
Query: 1 MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPK 60
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPK
Sbjct: 1 MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPK 60
Query: 61 WNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKL 120
WNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKL
Sbjct: 61 WNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKL 120
Query: 121 GPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHIT 180
GPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHIT
Sbjct: 121 GPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHIT 180
Query: 181 RTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRN 240
RTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRN
Sbjct: 181 RTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRN 240
Query: 241 YMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLP 300
YMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLP
Sbjct: 241 YMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLP 300
Query: 301 PGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDT 360
PGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDT
Sbjct: 301 PGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDT 360
Query: 361 ECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK 420
ECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK
Sbjct: 361 ECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK 420
Query: 421 RLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHL 480
RLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHL
Sbjct: 421 RLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHL 480
Query: 481 SYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILEND 540
SYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILEND
Sbjct: 481 SYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILEND 540
Query: 541 ITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLA 600
ITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLA
Sbjct: 541 ITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLA 600
Query: 601 LQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAV 660
LQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAV
Sbjct: 601 LQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAV 660
Query: 661 EFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRI 720
EFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRI
Sbjct: 661 EFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRI 720
Query: 721 DIPPYESYEKLYEKLLTAIEETCGFAVE 748
DIPPYESYEKLYEKLLTAIEETCGFAVE
Sbjct: 721 DIPPYESYEKLYEKLLTAIEETCGFAVE 748
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 1160 bits (3002), Expect = 0.0
Identities = 573/766 (74%), Positives = 636/766 (83%), Gaps = 53/766 (6%)
Query: 1 MSNPGGRRNGP-VKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDP 59
MSNPG RRNG +K+RLTVLCAKNL KKDFFRLPDPFAK+VVDGSGQCHSTDTVKNTLDP
Sbjct: 1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP 60
Query: 60 KWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCK 119
KWNQHYDLY+GK+DS+TISVWNHKKIHKKQGAGFLGCVRLLSNAI+RLKDTGYQRLDLCK
Sbjct: 61 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK 120
Query: 120 LGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHI 179
L P+D D VRGQIVVSLQ+RDRIGTGG VVDC L +N+ G +
Sbjct: 121 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENE------------GTVY----- 163
Query: 180 TRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCG---------QSSDPRLAE 230
E S PGRPLSCF++E P + + GA G S D RL
Sbjct: 164 --------------EDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQA 209
Query: 231 RRVRSQRHRNYM----SRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPR 286
+R+R+ R + +R H H P+LPEGYEQRTT QGQVYFLHTQTGVSTWHDPR+PR
Sbjct: 210 QRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPR 269
Query: 287 DLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKD 346
DL+++NC+ELGPLPPGWE+R+T +GR+YFVDHNNRTTQFTDPR LH ++N Q QLK+
Sbjct: 270 DLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPR----LHHIMNHQCQLKE 325
Query: 347 QQQQ-QVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEE 405
Q + S + E L RY+RDLVQKLK+LR ELS QQPQAGHCRIEVSREEIFEE
Sbjct: 326 PSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEE 385
Query: 406 SYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIY 465
SYRQ+MKMRPKDL KRLM+KFRGEEGLDYGGVAREWLYLL HEMLNPYYGLFQYS D+IY
Sbjct: 386 SYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIY 445
Query: 466 TLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELV 525
LQINPDS++NP+HLSYFHFVGRIMG+AVFHGHYI+GGFT+PFYKQLLGK I L D+E V
Sbjct: 446 MLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESV 505
Query: 526 DPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLY 585
DP+LH SLVWILENDIT VLDHTFCVEHNA+G I+QHELKPNG+++PV EENKKEYVRLY
Sbjct: 506 DPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLY 565
Query: 586 VNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH 645
VNWRF+RGIEAQFLALQKGFNE+IPQHLLK FD+KELELII GL KID+NDWK NTRLKH
Sbjct: 566 VNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH 625
Query: 646 CTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQ---GAAGPRLFTIHQ 702
C DSNIV+WFW+AVE FDEERRARLLQFVTGS+RVPLQGFKALQ GAAGPRLFTIH
Sbjct: 626 CVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHL 685
Query: 703 IDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 748
IDA T+NLPKAHTCFNRIDIPPYESYEKLYEKLLTA+EETCGFAVE
Sbjct: 686 IDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 731
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 1146 bits (2965), Expect = 0.0
Identities = 573/792 (72%), Positives = 636/792 (80%), Gaps = 79/792 (9%)
Query: 1 MSNPGGRRNGP-VKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDP 59
MSNPG RRNG +K+RLTVLCAKNL KKDFFRLPDPFAK+VVDGSGQCHSTDTVKNTLDP
Sbjct: 1 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP 60
Query: 60 KWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCK 119
KWNQHYDLY+GK+DS+TISVWNHKKIHKKQGAGFLGCVRLLSNAI+RLKDTGYQRLDLCK
Sbjct: 61 KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK 120
Query: 120 LGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHI 179
L P+D D VRGQIVVSLQ+RDRIGTGG VVDC L +N+ G +
Sbjct: 121 LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENE------------GTVY----- 163
Query: 180 TRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCG---------QSSDPRLAE 230
E S PGRPLSCF++E P + + GA G S D RL
Sbjct: 164 --------------EDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQA 209
Query: 231 RRVRSQRHRNYM----SRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRV-- 284
+R+R+ R + +R H H P+LPEGYEQRTT QGQVYFLHTQTGVSTWHDPR+
Sbjct: 210 QRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS 269
Query: 285 ------------------------PRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNN 320
PRDL+++NC+ELGPLPPGWE+R+T +GR+YFVDHNN
Sbjct: 270 PSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNN 329
Query: 321 RTTQFTDPRLSANLHLVLNRQNQLKDQQQQ-QVVSLCPDDTECLTVPRYKRDLVQKLKIL 379
RTTQFTDPR LH ++N Q QLK+ Q + S + E L RY+RDLVQKLK+L
Sbjct: 330 RTTQFTDPR----LHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVL 385
Query: 380 RQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAR 439
R ELS QQPQAGHCRIEVSREEIFEESYRQ+MKMRPKDL KRLM+KFRGEEGLDYGGVAR
Sbjct: 386 RHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAR 445
Query: 440 EWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHY 499
EWLYLL HEMLNPYYGLFQYS D+IY LQINPDS++NP+HLSYFHFVGRIMG+AVFHGHY
Sbjct: 446 EWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHY 505
Query: 500 IDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEI 559
I+GGFT+PFYKQLLGK I L D+E VDP+LH SLVWILENDIT VLDHTFCVEHNA+G I
Sbjct: 506 INGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRI 565
Query: 560 IQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDE 619
+QHELKPNG+++PV EENKKEYVRLYVNWRF+RGIEAQFLALQKGFNE+IPQHLLK FD+
Sbjct: 566 LQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQ 625
Query: 620 KELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSS 679
KELELII GL KID+NDWK NTRLKHC DSNIV+WFW+AVE FDEERRARLLQFVTGS+
Sbjct: 626 KELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGST 685
Query: 680 RVPLQGFKALQ---GAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLL 736
RVPLQGFKALQ GAAGPRLFTIH IDA T+NLPKAHTCFNRIDIPPYESYEKLYEKLL
Sbjct: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745
Query: 737 TAIEETCGFAVE 748
TA+EETCGFAVE
Sbjct: 746 TAVEETCGFAVE 757
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 509 bits (1311), Expect = e-144
Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%)
Query: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203
LP GWEER+ A GR Y+NH RTT W RP +E + G RP S
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260
V + P+ G + ++ L+ + N H T LP G+E R
Sbjct: 326 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 385
Query: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315
G+ +F+ T +TW DPR+ R +++N +LGPLPPGWE R GR ++
Sbjct: 386 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 445
Query: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373
+DHN++ TQ+ DPRL +T P Y R+
Sbjct: 446 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 477
Query: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432
QK R++L + +++ R IFEESYR++M ++ D+ K RL I+F E+GL
Sbjct: 478 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 537
Query: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491
DYGGVAREW +LLS EM NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ G
Sbjct: 538 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 597
Query: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551
+AVFHG +DG F PFYK +LGK ITL+DME VD + +NSL WILEND T LD FC+
Sbjct: 598 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 656
Query: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611
+ +G+ Q +LKPNG I V ENK+EY+ L + WRF+ ++ Q A +GF E++P
Sbjct: 657 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 716
Query: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670
L+K FDE ELEL++CGLG +DVNDW+ ++ K+ P+ +++WFWKAV D E+R R
Sbjct: 717 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 776
Query: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730
LLQFVTG+SRVP+ GF L G+ GP+LFTI Q + LP+AHTCFNR+D+PPYE++E
Sbjct: 777 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 835
Query: 731 LYEKLLTAIEETCGF 745
L EKLL A+E GF
Sbjct: 836 LREKLLMAVENAQGF 850
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/168 (27%), Positives = 67/168 (39%), Gaps = 33/168 (19%)
Query: 99 LLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS------ 152
LL ++ + G+ RL + + N GQ + RD + G +VVD +
Sbjct: 11 LLRPRSHKSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQH 65
Query: 153 --RLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENT 210
L LP GWEE+ GR Y+NH RTTQW RP+ +S D N
Sbjct: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI 116
Query: 211 PISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYE 258
+ + A RR RS+RH + D+PE +E
Sbjct: 117 -----------RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE 153
Score = 47.8 bits (112), Expect = 4e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 33.9 bits (76), Expect = 0.57
Identities = 11/33 (33%), Positives = 19/33 (57%)
Query: 250 PPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDP 282
PP LP G+E++ G+ Y+++ + WH P
Sbjct: 71 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 509 bits (1311), Expect = e-144
Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%)
Query: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203
LP GWEER+ A GR Y+NH RTT W RP +E + G RP S
Sbjct: 367 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 426
Query: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260
V + P+ G + ++ L+ + N H T LP G+E R
Sbjct: 427 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 486
Query: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315
G+ +F+ T +TW DPR+ R +++N +LGPLPPGWE R GR ++
Sbjct: 487 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 546
Query: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373
+DHN++ TQ+ DPRL +T P Y R+
Sbjct: 547 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 578
Query: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432
QK R++L + +++ R IFEESYR++M ++ D+ K RL I+F E+GL
Sbjct: 579 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 638
Query: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491
DYGGVAREW +LLS EM NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ G
Sbjct: 639 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 698
Query: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551
+AVFHG +DG F PFYK +LGK ITL+DME VD + +NSL WILEND T LD FC+
Sbjct: 699 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 757
Query: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611
+ +G+ Q +LKPNG I V ENK+EY+ L + WRF+ ++ Q A +GF E++P
Sbjct: 758 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 817
Query: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670
L+K FDE ELEL++CGLG +DVNDW+ ++ K+ P+ +++WFWKAV D E+R R
Sbjct: 818 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 877
Query: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730
LLQFVTG+SRVP+ GF L G+ GP+LFTI Q + LP+AHTCFNR+D+PPYE++E
Sbjct: 878 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 936
Query: 731 LYEKLLTAIEETCGF 745
L EKLL A+E GF
Sbjct: 937 LREKLLMAVENAQGF 951
Score = 87.0 bits (214), Expect = 6e-17
Identities = 106/406 (26%), Positives = 154/406 (37%), Gaps = 122/406 (30%)
Query: 14 LRLTVLCAKNLVKKDFFRLPDPFAKV---VVDGSGQCH--STDTVKNTLDPKWNQHYDLY 68
LR+ V+ +L KKD F DP+ K+ V D + + T T+K TL+PKWN+ +
Sbjct: 22 LRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFR 81
Query: 69 IGKSDS-VTISVWNHKKIHKKQGAGFLGCVR----------------------LLSNAIN 105
+ S+ + V++ ++ + FLG V LL +
Sbjct: 82 VNPSNHRLLFEVFDENRLTRDD---FLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSH 138
Query: 106 RLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS--------RLFDN 157
+ + G+ RL + + N GQ + RD + G +VVD + L
Sbjct: 139 KSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPP 193
Query: 158 DLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNG 217
LP GWEE+ GR Y+NH RTTQW RP+ +S D N
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI------- 237
Query: 218 ATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVS 277
+ + A RR RS+RH + D+PE +E T +V G++
Sbjct: 238 ----RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE---TISEEVNIAGDSLGLA 290
Query: 278 TWHDP------RVPRDLS-----------NINCE------------------------EL 296
P P++LS + N E E
Sbjct: 291 LPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ 350
Query: 297 GPLPP--------------GWEIRNTATGRVYFVDHNNRTTQFTDP 328
G LPP GWE R A GR Y+V+HNNRTT +T P
Sbjct: 351 GHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 396
Score = 47.8 bits (112), Expect = 4e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 226
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 509 bits (1311), Expect = e-144
Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%)
Query: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203
LP GWEER+ A GR Y+NH RTT W RP +E + G RP S
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
Query: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260
V + P+ G + ++ L+ + N H T LP G+E R
Sbjct: 306 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 365
Query: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315
G+ +F+ T +TW DPR+ R +++N +LGPLPPGWE R GR ++
Sbjct: 366 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 425
Query: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373
+DHN++ TQ+ DPRL +T P Y R+
Sbjct: 426 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 457
Query: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432
QK R++L + +++ R IFEESYR++M ++ D+ K RL I+F E+GL
Sbjct: 458 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 517
Query: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491
DYGGVAREW +LLS EM NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ G
Sbjct: 518 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 577
Query: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551
+AVFHG +DG F PFYK +LGK ITL+DME VD + +NSL WILEND T LD FC+
Sbjct: 578 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 636
Query: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611
+ +G+ Q +LKPNG I V ENK+EY+ L + WRF+ ++ Q A +GF E++P
Sbjct: 637 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 696
Query: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670
L+K FDE ELEL++CGLG +DVNDW+ ++ K+ P+ +++WFWKAV D E+R R
Sbjct: 697 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 756
Query: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730
LLQFVTG+SRVP+ GF L G+ GP+LFTI Q + LP+AHTCFNR+D+PPYE++E
Sbjct: 757 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 815
Query: 731 LYEKLLTAIEETCGF 745
L EKLL A+E GF
Sbjct: 816 LREKLLMAVENAQGF 830
Score = 63.5 bits (153), Expect = 7e-10
Identities = 78/293 (26%), Positives = 107/293 (36%), Gaps = 91/293 (31%)
Query: 99 LLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS------ 152
LL ++ + G+ RL + + N GQ + RD + G +VVD +
Sbjct: 11 LLRPRSHKSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQH 65
Query: 153 --RLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENT 210
L LP GWEE+ GR Y+NH RTTQW RP+ +S D N
Sbjct: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI 116
Query: 211 PISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFL 270
+ + A RR RS+RH + D+PE +E T +V
Sbjct: 117 -----------RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE---TISEEVNIA 162
Query: 271 HTQTGVSTWHDP------RVPRDLS-----------NINCE------------------- 294
G++ P P++LS + N E
Sbjct: 163 GDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSV 222
Query: 295 -----ELGPLPP--------------GWEIRNTATGRVYFVDHNNRTTQFTDP 328
E G LPP GWE R A GR Y+V+HNNRTT +T P
Sbjct: 223 TDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
Score = 47.8 bits (112), Expect = 4e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 509 bits (1311), Expect = e-144
Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%)
Query: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203
LP GWEER+ A GR Y+NH RTT W RP +E + G RP S
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
Query: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260
V + P+ G + ++ L+ + N H T LP G+E R
Sbjct: 306 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 365
Query: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315
G+ +F+ T +TW DPR+ R +++N +LGPLPPGWE R GR ++
Sbjct: 366 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 425
Query: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373
+DHN++ TQ+ DPRL +T P Y R+
Sbjct: 426 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 457
Query: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432
QK R++L + +++ R IFEESYR++M ++ D+ K RL I+F E+GL
Sbjct: 458 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 517
Query: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491
DYGGVAREW +LLS EM NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ G
Sbjct: 518 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 577
Query: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551
+AVFHG +DG F PFYK +LGK ITL+DME VD + +NSL WILEND T LD FC+
Sbjct: 578 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 636
Query: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611
+ +G+ Q +LKPNG I V ENK+EY+ L + WRF+ ++ Q A +GF E++P
Sbjct: 637 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 696
Query: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670
L+K FDE ELEL++CGLG +DVNDW+ ++ K+ P+ +++WFWKAV D E+R R
Sbjct: 697 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 756
Query: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730
LLQFVTG+SRVP+ GF L G+ GP+LFTI Q + LP+AHTCFNR+D+PPYE++E
Sbjct: 757 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 815
Query: 731 LYEKLLTAIEETCGF 745
L EKLL A+E GF
Sbjct: 816 LREKLLMAVENAQGF 830
Score = 63.5 bits (153), Expect = 7e-10
Identities = 78/293 (26%), Positives = 107/293 (36%), Gaps = 91/293 (31%)
Query: 99 LLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS------ 152
LL ++ + G+ RL + + N GQ + RD + G +VVD +
Sbjct: 11 LLRPRSHKSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQH 65
Query: 153 --RLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENT 210
L LP GWEE+ GR Y+NH RTTQW RP+ +S D N
Sbjct: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI 116
Query: 211 PISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFL 270
+ + A RR RS+RH + D+PE +E T +V
Sbjct: 117 -----------RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE---TISEEVNIA 162
Query: 271 HTQTGVSTWHDP------RVPRDLS-----------NINCE------------------- 294
G++ P P++LS + N E
Sbjct: 163 GDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSV 222
Query: 295 -----ELGPLPP--------------GWEIRNTATGRVYFVDHNNRTTQFTDP 328
E G LPP GWE R A GR Y+V+HNNRTT +T P
Sbjct: 223 TDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
Score = 47.8 bits (112), Expect = 4e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 509 bits (1311), Expect = e-144
Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%)
Query: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203
LP GWEER+ A GR Y+NH RTT W RP +E + G RP S
Sbjct: 359 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 418
Query: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260
V + P+ G + ++ L+ + N H T LP G+E R
Sbjct: 419 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 478
Query: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315
G+ +F+ T +TW DPR+ R +++N +LGPLPPGWE R GR ++
Sbjct: 479 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 538
Query: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373
+DHN++ TQ+ DPRL +T P Y R+
Sbjct: 539 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 570
Query: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432
QK R++L + +++ R IFEESYR++M ++ D+ K RL I+F E+GL
Sbjct: 571 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 630
Query: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491
DYGGVAREW +LLS EM NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ G
Sbjct: 631 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 690
Query: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551
+AVFHG +DG F PFYK +LGK ITL+DME VD + +NSL WILEND T LD FC+
Sbjct: 691 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 749
Query: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611
+ +G+ Q +LKPNG I V ENK+EY+ L + WRF+ ++ Q A +GF E++P
Sbjct: 750 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 809
Query: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670
L+K FDE ELEL++CGLG +DVNDW+ ++ K+ P+ +++WFWKAV D E+R R
Sbjct: 810 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 869
Query: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730
LLQFVTG+SRVP+ GF L G+ GP+LFTI Q + LP+AHTCFNR+D+PPYE++E
Sbjct: 870 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 928
Query: 731 LYEKLLTAIEETCGF 745
L EKLL A+E GF
Sbjct: 929 LREKLLMAVENAQGF 943
Score = 87.0 bits (214), Expect = 6e-17
Identities = 106/406 (26%), Positives = 154/406 (37%), Gaps = 122/406 (30%)
Query: 14 LRLTVLCAKNLVKKDFFRLPDPFAKV---VVDGSGQCH--STDTVKNTLDPKWNQHYDLY 68
LR+ V+ +L KKD F DP+ K+ V D + + T T+K TL+PKWN+ +
Sbjct: 14 LRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFR 73
Query: 69 IGKSDS-VTISVWNHKKIHKKQGAGFLGCVR----------------------LLSNAIN 105
+ S+ + V++ ++ + FLG V LL +
Sbjct: 74 VNPSNHRLLFEVFDENRLTRDD---FLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSH 130
Query: 106 RLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS--------RLFDN 157
+ + G+ RL + + N GQ + RD + G +VVD + L
Sbjct: 131 KSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPP 185
Query: 158 DLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNG 217
LP GWEE+ GR Y+NH RTTQW RP+ +S D N
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI------- 229
Query: 218 ATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVS 277
+ + A RR RS+RH + D+PE +E T +V G++
Sbjct: 230 ----RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE---TISEEVNIAGDSLGLA 282
Query: 278 TWHDP------RVPRDLS-----------NINCE------------------------EL 296
P P++LS + N E E
Sbjct: 283 LPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ 342
Query: 297 GPLPP--------------GWEIRNTATGRVYFVDHNNRTTQFTDP 328
G LPP GWE R A GR Y+V+HNNRTT +T P
Sbjct: 343 GHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 388
Score = 47.8 bits (112), Expect = 4e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 218
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 509 bits (1311), Expect = e-144
Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%)
Query: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203
LP GWEER+ A GR Y+NH RTT W RP +E + G RP S
Sbjct: 379 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 438
Query: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260
V + P+ G + ++ L+ + N H T LP G+E R
Sbjct: 439 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 498
Query: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315
G+ +F+ T +TW DPR+ R +++N +LGPLPPGWE R GR ++
Sbjct: 499 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 558
Query: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373
+DHN++ TQ+ DPRL +T P Y R+
Sbjct: 559 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 590
Query: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432
QK R++L + +++ R IFEESYR++M ++ D+ K RL I+F E+GL
Sbjct: 591 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 650
Query: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491
DYGGVAREW +LLS EM NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ G
Sbjct: 651 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 710
Query: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551
+AVFHG +DG F PFYK +LGK ITL+DME VD + +NSL WILEND T LD FC+
Sbjct: 711 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 769
Query: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611
+ +G+ Q +LKPNG I V ENK+EY+ L + WRF+ ++ Q A +GF E++P
Sbjct: 770 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 829
Query: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670
L+K FDE ELEL++CGLG +DVNDW+ ++ K+ P+ +++WFWKAV D E+R R
Sbjct: 830 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 889
Query: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730
LLQFVTG+SRVP+ GF L G+ GP+LFTI Q + LP+AHTCFNR+D+PPYE++E
Sbjct: 890 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 948
Query: 731 LYEKLLTAIEETCGF 745
L EKLL A+E GF
Sbjct: 949 LREKLLMAVENAQGF 963
Score = 72.8 bits (177), Expect = 1e-12
Identities = 75/281 (26%), Positives = 114/281 (40%), Gaps = 64/281 (22%)
Query: 14 LRLTVLCAKNLVKKDFFRLPDPFAKV---VVDGSGQCH--STDTVKNTLDPKWNQHYDLY 68
LR+ V+ +L KKD F DP+ K+ V D + + T T+K TL+PKWN+ +
Sbjct: 14 LRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFR 73
Query: 69 IGKSDS-VTISVWNHKKIHKKQGAGFLGCVR----------------------LLSNAIN 105
+ S+ + V++ ++ + FLG V LL +
Sbjct: 74 VNPSNHRLLFEVFDENRLTRDD---FLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSH 130
Query: 106 RLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS--------RLFDN 157
+ + G+ RL + + N GQ + RD + G +VVD + L
Sbjct: 131 KSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPP 185
Query: 158 DLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNG 217
LP GWEE+ GR Y+NH RTTQW RP+ +S D N
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI------- 229
Query: 218 ATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYE 258
+ + A RR RS+RH + D+PE +E
Sbjct: 230 ----RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE 266
Score = 47.8 bits (112), Expect = 4e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 218
Score = 33.9 bits (76), Expect = 0.57
Identities = 11/33 (33%), Positives = 19/33 (57%)
Query: 250 PPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDP 282
PP LP G+E++ G+ Y+++ + WH P
Sbjct: 184 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 509 bits (1311), Expect = e-144
Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%)
Query: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203
LP GWEER+ A GR Y+NH RTT W RP +E + G RP S
Sbjct: 387 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 446
Query: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260
V + P+ G + ++ L+ + N H T LP G+E R
Sbjct: 447 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 506
Query: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315
G+ +F+ T +TW DPR+ R +++N +LGPLPPGWE R GR ++
Sbjct: 507 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 566
Query: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373
+DHN++ TQ+ DPRL +T P Y R+
Sbjct: 567 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 598
Query: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432
QK R++L + +++ R IFEESYR++M ++ D+ K RL I+F E+GL
Sbjct: 599 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 658
Query: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491
DYGGVAREW +LLS EM NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ G
Sbjct: 659 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 718
Query: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551
+AVFHG +DG F PFYK +LGK ITL+DME VD + +NSL WILEND T LD FC+
Sbjct: 719 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 777
Query: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611
+ +G+ Q +LKPNG I V ENK+EY+ L + WRF+ ++ Q A +GF E++P
Sbjct: 778 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 837
Query: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670
L+K FDE ELEL++CGLG +DVNDW+ ++ K+ P+ +++WFWKAV D E+R R
Sbjct: 838 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 897
Query: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730
LLQFVTG+SRVP+ GF L G+ GP+LFTI Q + LP+AHTCFNR+D+PPYE++E
Sbjct: 898 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 956
Query: 731 LYEKLLTAIEETCGF 745
L EKLL A+E GF
Sbjct: 957 LREKLLMAVENAQGF 971
Score = 72.8 bits (177), Expect = 1e-12
Identities = 75/281 (26%), Positives = 114/281 (40%), Gaps = 64/281 (22%)
Query: 14 LRLTVLCAKNLVKKDFFRLPDPFAKV---VVDGSGQCH--STDTVKNTLDPKWNQHYDLY 68
LR+ V+ +L KKD F DP+ K+ V D + + T T+K TL+PKWN+ +
Sbjct: 22 LRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFR 81
Query: 69 IGKSDS-VTISVWNHKKIHKKQGAGFLGCVR----------------------LLSNAIN 105
+ S+ + V++ ++ + FLG V LL +
Sbjct: 82 VNPSNHRLLFEVFDENRLTRDD---FLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSH 138
Query: 106 RLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS--------RLFDN 157
+ + G+ RL + + N GQ + RD + G +VVD + L
Sbjct: 139 KSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPP 193
Query: 158 DLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNG 217
LP GWEE+ GR Y+NH RTTQW RP+ +S D N
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI------- 237
Query: 218 ATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYE 258
+ + A RR RS+RH + D+PE +E
Sbjct: 238 ----RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE 274
Score = 47.8 bits (112), Expect = 4e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 226
Score = 33.9 bits (76), Expect = 0.57
Identities = 11/33 (33%), Positives = 19/33 (57%)
Query: 250 PPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDP 282
PP LP G+E++ G+ Y+++ + WH P
Sbjct: 192 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 509 bits (1311), Expect = e-144
Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%)
Query: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203
LP GWEER+ A GR Y+NH RTT W RP +E + G RP S
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260
V + P+ G + ++ L+ + N H T LP G+E R
Sbjct: 326 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 385
Query: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315
G+ +F+ T +TW DPR+ R +++N +LGPLPPGWE R GR ++
Sbjct: 386 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 445
Query: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373
+DHN++ TQ+ DPRL +T P Y R+
Sbjct: 446 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 477
Query: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432
QK R++L + +++ R IFEESYR++M ++ D+ K RL I+F E+GL
Sbjct: 478 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 537
Query: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491
DYGGVAREW +LLS EM NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ G
Sbjct: 538 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 597
Query: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551
+AVFHG +DG F PFYK +LGK ITL+DME VD + +NSL WILEND T LD FC+
Sbjct: 598 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 656
Query: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611
+ +G+ Q +LKPNG I V ENK+EY+ L + WRF+ ++ Q A +GF E++P
Sbjct: 657 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 716
Query: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670
L+K FDE ELEL++CGLG +DVNDW+ ++ K+ P+ +++WFWKAV D E+R R
Sbjct: 717 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 776
Query: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730
LLQFVTG+SRVP+ GF L G+ GP+LFTI Q + LP+AHTCFNR+D+PPYE++E
Sbjct: 777 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 835
Query: 731 LYEKLLTAIEETCGF 745
L EKLL A+E GF
Sbjct: 836 LREKLLMAVENAQGF 850
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/168 (27%), Positives = 67/168 (39%), Gaps = 33/168 (19%)
Query: 99 LLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS------ 152
LL ++ + G+ RL + + N GQ + RD + G +VVD +
Sbjct: 11 LLRPRSHKSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQH 65
Query: 153 --RLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENT 210
L LP GWEE+ GR Y+NH RTTQW RP+ +S D N
Sbjct: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI 116
Query: 211 PISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYE 258
+ + A RR RS+RH + D+PE +E
Sbjct: 117 -----------RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE 153
Score = 47.8 bits (112), Expect = 4e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 33.9 bits (76), Expect = 0.57
Identities = 11/33 (33%), Positives = 19/33 (57%)
Query: 250 PPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDP 282
PP LP G+E++ G+ Y+++ + WH P
Sbjct: 71 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 509 bits (1311), Expect = e-144
Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%)
Query: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203
LP GWEER+ A GR Y+NH RTT W RP +E + G RP S
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260
V + P+ G + ++ L+ + N H T LP G+E R
Sbjct: 326 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 385
Query: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315
G+ +F+ T +TW DPR+ R +++N +LGPLPPGWE R GR ++
Sbjct: 386 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 445
Query: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373
+DHN++ TQ+ DPRL +T P Y R+
Sbjct: 446 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 477
Query: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432
QK R++L + +++ R IFEESYR++M ++ D+ K RL I+F E+GL
Sbjct: 478 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 537
Query: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491
DYGGVAREW +LLS EM NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ G
Sbjct: 538 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 597
Query: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551
+AVFHG +DG F PFYK +LGK ITL+DME VD + +NSL WILEND T LD FC+
Sbjct: 598 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 656
Query: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611
+ +G+ Q +LKPNG I V ENK+EY+ L + WRF+ ++ Q A +GF E++P
Sbjct: 657 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 716
Query: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670
L+K FDE ELEL++CGLG +DVNDW+ ++ K+ P+ +++WFWKAV D E+R R
Sbjct: 717 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 776
Query: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730
LLQFVTG+SRVP+ GF L G+ GP+LFTI Q + LP+AHTCFNR+D+PPYE++E
Sbjct: 777 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 835
Query: 731 LYEKLLTAIEETCGF 745
L EKLL A+E GF
Sbjct: 836 LREKLLMAVENAQGF 850
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/168 (27%), Positives = 67/168 (39%), Gaps = 33/168 (19%)
Query: 99 LLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS------ 152
LL ++ + G+ RL + + N GQ + RD + G +VVD +
Sbjct: 11 LLRPRSHKSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQH 65
Query: 153 --RLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENT 210
L LP GWEE+ GR Y+NH RTTQW RP+ +S D N
Sbjct: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI 116
Query: 211 PISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYE 258
+ + A RR RS+RH + D+PE +E
Sbjct: 117 -----------RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE 153
Score = 47.8 bits (112), Expect = 4e-05
Identities = 20/33 (60%), Positives = 24/33 (72%)
Query: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
PLPPGWE + GR Y+V+HNNRTTQ+ P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 33.9 bits (76), Expect = 0.57
Identities = 11/33 (33%), Positives = 19/33 (57%)
Query: 250 PPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDP 282
PP LP G+E++ G+ Y+++ + WH P
Sbjct: 71 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 491 bits (1263), Expect = e-138
Identities = 270/639 (42%), Positives = 375/639 (58%), Gaps = 45/639 (7%)
Query: 122 PNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITR 181
PN N T + + +G Q + + + LP GWE+R +GR+ Y++H T+
Sbjct: 265 PNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTK 324
Query: 182 TTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSD-PRLAERRVRSQRHRN 240
TT WERP P E + R +VD NT + T + + +R + Q
Sbjct: 325 TTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQ 384
Query: 241 YMSRTHL---------HTP-PDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSN 290
+ S+ L H P LP G+E+R G+VY+++ T + W DPR +
Sbjct: 385 HFSQRFLYQSSSASTDHDPLGPLPPGWEKRQ-DNGRVYYVNHNTRTTQWEDPRTQGMIQE 443
Query: 291 INCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQ 350
LPPGWE++ T+ G YFVDHN RTT F DPR
Sbjct: 444 ------PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFE----------------- 480
Query: 351 QVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQV 410
T+ + Y R K R L H +I VSR+ +FE+S++Q+
Sbjct: 481 -------SGTKQGSPGAYDRSFRWKYHQFRF-LCHSNALPSHVKISVSRQTLFEDSFQQI 532
Query: 411 MKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQIN 470
M M+P DL +RL I RGEEGLDYGG+AREW +LLSHE+LNP Y LF+Y+ + Y LQIN
Sbjct: 533 MNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQIN 592
Query: 471 PDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLH 530
P S++NP+HL+YF F+GR + MA++HG +ID GFTLPFYK++L K TL D+E +DP+ +
Sbjct: 593 PASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFY 652
Query: 531 NSLVWILENDITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWR 589
NS+VWI EN++ L+ F + G++ HELK G+SI V EENK+EY+ L +WR
Sbjct: 653 NSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWR 712
Query: 590 FLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPD 649
F RG+E Q A GFNEV P L+ FDEKELEL++CG+ +ID++DW+ +T +H T +
Sbjct: 713 FTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKN 772
Query: 650 SNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNN 709
S ++WFW+ V+ D E+R RLLQFVTG+ R+P+ GF L G+ GP+ F I ++ T
Sbjct: 773 SKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-W 831
Query: 710 LPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 748
LP++HTCFNR+D+PPY+SYE+L EKLL AIEET GF E
Sbjct: 832 LPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE 870
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 489 bits (1260), Expect = e-138
Identities = 261/595 (43%), Positives = 362/595 (60%), Gaps = 56/595 (9%)
Query: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGA 218
LP GWE R GRI Y++H TRTT W+RPT + R + + + + G
Sbjct: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESV------RNYEQWQLQRSQLQGAM-- 370
Query: 219 TCGQSSDPRLAERRVRSQRHRNYMSRTHLHTP-PDLPEGYEQRTTQQGQVYFLHTQTGVS 277
+ +R + + S++ P LP G+E+RT G+VYF++ T ++
Sbjct: 371 -------QQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRIT 423
Query: 278 TWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLV 337
W DPR L+ PLP GWE+R T G YFVDHN RTT + DPR +
Sbjct: 424 QWEDPRSQGQLNE------KPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKS---A 474
Query: 338 LNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILR---QELSQQQPQAGHCR 394
L+ Q+ Y RD K++ R Q+L+ Q H +
Sbjct: 475 LDNGPQIA----------------------YVRDFKAKVQYFRFWCQQLAMPQ----HIK 508
Query: 395 IEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYY 454
I V+R+ +FE+S++Q+M P+DL +RL + F GEEGLDYGGVAREW +LLSHE+LNP Y
Sbjct: 509 ITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMY 568
Query: 455 GLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLG 514
LF+Y+ D Y LQINP S +NP+HL YF F+GR + MA+FHG +ID GF+LPFYK++L
Sbjct: 569 CLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILN 628
Query: 515 KSITLDDMELVDPDLHNSLVWILENDITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPV 573
K + L D+E +DP+ +NSL+W+ EN+I L+ F V+ GEI H+LKPNG +I V
Sbjct: 629 KPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILV 688
Query: 574 NEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKID 633
EENK+EY+R+ WR RG+E Q A +GFNE++PQ L+ FD KELE+++CG+ +ID
Sbjct: 689 TEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEID 748
Query: 634 VNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAA 693
+NDW+ + +H S + WFW+ V+ D E+R RLLQFVTG+ R+P+ GF L G+
Sbjct: 749 LNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN 808
Query: 694 GPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 748
GP+ F I ++ N LP++HTCFNR+D+PPY+SYE+L EKLL AIEET GF E
Sbjct: 809 GPQKFCIEKVGK-ENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 862
Score = 85.1 bits (209), Expect = 2e-16
Identities = 98/378 (25%), Positives = 149/378 (39%), Gaps = 64/378 (16%)
Query: 13 KLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKS 72
+L++TV+ AK K + P P+ +V VDG Q T+ NT PKW Q + +
Sbjct: 19 QLQITVISAKLKENKKNWFGPSPYVEVTVDG--QSKKTEKCNNTNSPKWKQPLTVIVTPV 76
Query: 73 DSVTISVWNHKKIHKKQ--GAGFLGCVRLLSNAINRLKDT------GYQR--------LD 116
+ VW+H+ + G L L + +L++ G + L
Sbjct: 77 SKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLS 136
Query: 117 LCKLGPN-DNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPD-----GWEERRTAS 170
+C G +++ V +S + G + D +R+ N D E RR +
Sbjct: 137 ICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSG 196
Query: 171 GRIQYLNH----ITRTTQWERPT-----RPASEYSSP-------GRPLSCFVDENTPISG 214
L++ +R + RP RPAS SP G NT +
Sbjct: 197 NNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNT 256
Query: 215 TNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQT 274
+ GAT G ++ R N + T LP G+EQR Q G+VY++
Sbjct: 257 SEGATSGLIIPLTISGGS--GPRPLNPV------TQAPLPPGWEQRVDQHGRVYYVDHVE 308
Query: 275 GVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSA-- 332
+TW P PLPPGWE R GR+Y+VDH RTT + P L +
Sbjct: 309 KRTTWDRPE--------------PLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVR 354
Query: 333 NLHLVLNRQNQLKDQQQQ 350
N +++QL+ QQ
Sbjct: 355 NYEQWQLQRSQLQGAMQQ 372
Score = 48.1 bits (113), Expect = 3e-05
Identities = 39/134 (29%), Positives = 52/134 (38%), Gaps = 56/134 (41%)
Query: 152 SRLFD--NDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDEN 209
S+ FD LP GWE+R ++GR+ ++NH TR TQWE
Sbjct: 390 SKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWE----------------------- 426
Query: 210 TPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYF 269
DPR S+ L+ P LPEG+E R T G YF
Sbjct: 427 ---------------DPR---------------SQGQLNEKP-LPEGWEMRFTVDGIPYF 455
Query: 270 LHTQTGVSTWHDPR 283
+ +T+ DPR
Sbjct: 456 VDHNRRTTTYIDPR 469
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 486 bits (1252), Expect = e-137
Identities = 266/597 (44%), Positives = 362/597 (60%), Gaps = 60/597 (10%)
Query: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGA 218
LP GWEE++ GR Y++H +RTT W +PT A+ +S L+ P S + +
Sbjct: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQ---LTSSQSSAGPQSQASTS 406
Query: 219 TCGQS-SDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVS 277
GQ + P E+ LP+G+E R G+ +F+ T +
Sbjct: 407 DSGQQVTQPSEIEQGF-------------------LPKGWEVRHAPNGRPFFIDHNTKTT 447
Query: 278 TWHDPR--VPRDL----SNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLS 331
TW DPR +P L S +LGPLPPGWE R GR+++++HN + TQ+ DPRL
Sbjct: 448 TWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRL- 506
Query: 332 ANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAG 391
+ V P VP Y RD +K + R++L +Q
Sbjct: 507 ------------------ENVAITGP------AVP-YSRDYKRKYEFFRRKLKKQNDIPN 541
Query: 392 HCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGLDYGGVAREWLYLLSHEML 450
+++ R + E+SYR++M ++ D K RL I+F GE+GLDYGGVAREW +L+S EM
Sbjct: 542 KFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMF 601
Query: 451 NPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFY 509
NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ GMAV+HG +DG F PFY
Sbjct: 602 NPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFY 661
Query: 510 KQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGK 569
K +L K ITL DME VD + +NSL WILEND T LD F ++ +G+ QHELK G
Sbjct: 662 KMMLHKPITLHDMESVDSEYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGGS 720
Query: 570 SIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGL 629
I V +NKKEY+ L + WRF+ I+ Q A ++GF E+IPQ L+K FDE ELEL++CGL
Sbjct: 721 EIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGL 780
Query: 630 GKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKA 688
G +DVNDW+ +T+ K+ + + +++WFWKAV D E+R RLLQFVTG+SRVP+ GF
Sbjct: 781 GDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAE 840
Query: 689 LQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745
L G+ GP+ FT+ Q LP+AHTCFNR+D+PPYES+E+L++KL AIE T GF
Sbjct: 841 LYGSNGPQSFTVEQW-GTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 896
Score = 50.4 bits (119), Expect = 6e-06
Identities = 37/144 (25%), Positives = 57/144 (39%), Gaps = 48/144 (33%)
Query: 144 TGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLS 203
+G QV S + LP GWE R +GR +++H T+TT WE
Sbjct: 408 SGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWE----------------- 450
Query: 204 CFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPD---LPEGYEQR 260
DPRL + + +T L T D LP G+E+R
Sbjct: 451 ---------------------DPRL-------KIPAHLRGKTSLDTSNDLGPLPPGWEER 482
Query: 261 TTQQGQVYFLHTQTGVSTWHDPRV 284
T G++++++ + W DPR+
Sbjct: 483 THTDGRIFYINHNIKRTQWEDPRL 506
Score = 50.1 bits (118), Expect = 8e-06
Identities = 29/89 (32%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 294 EELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVV 353
+E PLPPGWE R GR Y+V+H +R TQ+ P NL N QL+ Q+
Sbjct: 188 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTR 247
Query: 354 SLCPDDTECLTVPRYKRDLVQKLKILRQE 382
++TE + R+ + +I+R++
Sbjct: 248 RQISEETESVD----NRESSENWEIIRED 272
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 486 bits (1252), Expect = e-137
Identities = 266/597 (44%), Positives = 362/597 (60%), Gaps = 60/597 (10%)
Query: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGA 218
LP GWEE++ GR Y++H +RTT W +PT A+ +S L+ P S + +
Sbjct: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQ---LTSSQSSAGPQSQASTS 753
Query: 219 TCGQS-SDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVS 277
GQ + P E+ LP+G+E R G+ +F+ T +
Sbjct: 754 DSGQQVTQPSEIEQGF-------------------LPKGWEVRHAPNGRPFFIDHNTKTT 794
Query: 278 TWHDPR--VPRDL----SNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLS 331
TW DPR +P L S +LGPLPPGWE R GR+++++HN + TQ+ DPRL
Sbjct: 795 TWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRL- 853
Query: 332 ANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAG 391
+ V P VP Y RD +K + R++L +Q
Sbjct: 854 ------------------ENVAITGP------AVP-YSRDYKRKYEFFRRKLKKQNDIPN 888
Query: 392 HCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGLDYGGVAREWLYLLSHEML 450
+++ R + E+SYR++M ++ D K RL I+F GE+GLDYGGVAREW +L+S EM
Sbjct: 889 KFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMF 948
Query: 451 NPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFY 509
NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ GMAV+HG +DG F PFY
Sbjct: 949 NPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFY 1008
Query: 510 KQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGK 569
K +L K ITL DME VD + +NSL WILEND T LD F ++ +G+ QHELK G
Sbjct: 1009 KMMLHKPITLHDMESVDSEYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGGS 1067
Query: 570 SIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGL 629
I V +NKKEY+ L + WRF+ I+ Q A ++GF E+IPQ L+K FDE ELEL++CGL
Sbjct: 1068 EIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGL 1127
Query: 630 GKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKA 688
G +DVNDW+ +T+ K+ + + +++WFWKAV D E+R RLLQFVTG+SRVP+ GF
Sbjct: 1128 GDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAE 1187
Query: 689 LQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745
L G+ GP+ FT+ Q LP+AHTCFNR+D+PPYES+E+L++KL AIE T GF
Sbjct: 1188 LYGSNGPQSFTVEQW-GTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
Score = 50.4 bits (119), Expect = 6e-06
Identities = 37/144 (25%), Positives = 57/144 (39%), Gaps = 48/144 (33%)
Query: 144 TGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLS 203
+G QV S + LP GWE R +GR +++H T+TT WE
Sbjct: 755 SGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWE----------------- 797
Query: 204 CFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPD---LPEGYEQR 260
DPRL + + +T L T D LP G+E+R
Sbjct: 798 ---------------------DPRL-------KIPAHLRGKTSLDTSNDLGPLPPGWEER 829
Query: 261 TTQQGQVYFLHTQTGVSTWHDPRV 284
T G++++++ + W DPR+
Sbjct: 830 THTDGRIFYINHNIKRTQWEDPRL 853
Score = 50.1 bits (118), Expect = 8e-06
Identities = 29/89 (32%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 294 EELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVV 353
+E PLPPGWE R GR Y+V+H +R TQ+ P NL N QL+ Q+
Sbjct: 535 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTR 594
Query: 354 SLCPDDTECLTVPRYKRDLVQKLKILRQE 382
++TE + R+ + +I+R++
Sbjct: 595 RQISEETESVD----NRESSENWEIIRED 619
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 484 bits (1246), Expect = e-136
Identities = 269/604 (44%), Positives = 362/604 (59%), Gaps = 46/604 (7%)
Query: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTR--PASEYSSPGRPLSCFVDENTPISGTN 216
LP GWE+R+ GR Y++H TRTT WERP P E R +VD NT +
Sbjct: 351 LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQ 410
Query: 217 GATCG------QSSDPRLAERRVRSQRHRNYM-SRTHLHTPPD----LPEGYEQRTTQQG 265
T Q R + Q ++ Y+ S + L D LP G+E+R
Sbjct: 411 RPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTD 470
Query: 266 QVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQF 325
+VYF++ T + W DPR + EE PLP GWEIR T G YFVDHN RTT F
Sbjct: 471 RVYFVNHNTKTTQWEDPRT----QGLQNEE--PLPEGWEIRYTREGVRYFVDHNTRTTTF 524
Query: 326 TDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQ 385
DPR N ++ + Q Y+R KL R L Q
Sbjct: 525 KDPR---------NGKSSVTKGGPQIA---------------YERGFRWKLAHFRY-LCQ 559
Query: 386 QQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLL 445
H +I VSR+ +FE+S++Q+M ++P DL +RL + FRGEEGLDYGG+AREW +LL
Sbjct: 560 SNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLL 619
Query: 446 SHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFT 505
SHE+LNP Y LF+Y+ + Y LQINP S +NP+HLSYF F+GR + MA+FHG +ID GF+
Sbjct: 620 SHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFS 679
Query: 506 LPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGV-LDHTFCVEHNAYGEIIQHEL 564
LPFYK++L K +T+ D+E +D + +NSL+WI +N+I L+ F V+ G++ H+L
Sbjct: 680 LPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDL 739
Query: 565 KPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELEL 624
K G +I V EENK EY+ L WRF RG++ Q A GFNEV+P L+ FDEKELE+
Sbjct: 740 KLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEV 799
Query: 625 IICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQ 684
++CG+ ++D+ DW+ NT +H T +S + WFW+ V+ D E R RLLQFVTG+ R+PL
Sbjct: 800 MLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLG 859
Query: 685 GFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCG 744
GF L G+ GP+ F I ++ T LP++HTCFNR+D+PPY+SYE+L EKLL AIEET G
Sbjct: 860 GFAELMGSNGPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEG 918
Query: 745 FAVE 748
F E
Sbjct: 919 FGQE 922
Score = 38.5 bits (88), Expect = 0.023
Identities = 22/84 (26%), Positives = 45/84 (53%), Gaps = 3/84 (3%)
Query: 2 SNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKW 61
S+ +G ++L++TV AK KK++F + +VVVDG + T ++ +PKW
Sbjct: 8 SDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAI-YTEVVVDG--EITKTAKSSSSSNPKW 64
Query: 62 NQHYDLYIGKSDSVTISVWNHKKI 85
++ + + ++ VW+H+ +
Sbjct: 65 DEQLTVNVTPQTTLEFQVWSHRTL 88
Score = 35.0 bits (79), Expect = 0.25
Identities = 16/44 (36%), Positives = 24/44 (54%)
Query: 156 DNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG 199
+ LP+GWE R T G +++H TRTT ++ P S + G
Sbjct: 495 EEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGG 538
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 432 bits (1112), Expect = e-121
Identities = 220/451 (48%), Positives = 296/451 (65%), Gaps = 27/451 (5%)
Query: 299 LPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPD 358
LPPGWE++ T+ G YFVDHN RTT F DPR
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFE------------------------S 42
Query: 359 DTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDL 418
T+ + Y R K R L H +I VSR+ +FE+S++Q+M M+P DL
Sbjct: 43 GTKQGSPGAYDRSFRWKYHQFRF-LCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDL 101
Query: 419 WKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPE 478
+RL I RGEEGLDYGG+AREW +LLSHE+LNP Y LF+Y+ + Y LQINP S++NP+
Sbjct: 102 RRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPD 161
Query: 479 HLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILE 538
HL+YF F+GR + MA++HG +ID GFTLPFYK++L K TL D+E +DP+ +NS+VWI E
Sbjct: 162 HLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE 221
Query: 539 NDITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQ 597
N++ L+ F + G++ HELK G+SI V EENK+EY+ L +WRF RG+E Q
Sbjct: 222 NNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQ 281
Query: 598 FLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFW 657
A GFNEV P L+ FDEKELEL++CG+ +ID++DW+ +T +H T +S ++WFW
Sbjct: 282 TKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFW 341
Query: 658 KAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCF 717
+ V+ D E+R RLLQFVTG+ R+P+ GF L G+ GP+ F I ++ T LP++HTCF
Sbjct: 342 QVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCF 400
Query: 718 NRIDIPPYESYEKLYEKLLTAIEETCGFAVE 748
NR+D+PPY+SYE+L EKLL AIEET GF E
Sbjct: 401 NRLDLPPYKSYEQLREKLLYAIEETEGFGQE 431
Score = 33.5 bits (75), Expect = 0.74
Identities = 19/45 (42%), Positives = 26/45 (57%), Gaps = 5/45 (11%)
Query: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASE----YSSPG 199
LP GWE + T+ G +++H TRTT ++ P RP E SPG
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDP-RPGFESGTKQGSPG 50
Score = 33.1 bits (74), Expect = 0.97
Identities = 14/33 (42%), Positives = 20/33 (60%)
Query: 251 PDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPR 283
P LP G+E + T +G YF+ T +T+ DPR
Sbjct: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR 37
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 363 bits (931), Expect = e-100
Identities = 181/385 (47%), Positives = 255/385 (66%), Gaps = 5/385 (1%)
Query: 368 YKRDLVQKLKILRQELSQQQ--PQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMI 424
YKRD KL+ ++L + G ++ + R+ + E+++ Q+M KDL + +L +
Sbjct: 1189 YKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYV 1248
Query: 425 KFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFH 484
F GEEGLDY G +RE+ +L+S E+ NPYYGLF+YS +D YT+QI+P SA H +F
Sbjct: 1249 TFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFR 1308
Query: 485 FVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGV 544
F GRI+G+A+ H + +D FT PFYK LL L D+E +D + H SL W+ +NDI +
Sbjct: 1309 FSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDI 1368
Query: 545 LDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKG 604
LD TF V +G+I + ELKP G +IPV E+NKKEY+ V WR RG+ Q +L +G
Sbjct: 1369 LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRG 1428
Query: 605 FNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIV-KWFWKAVEFF 663
F EV+ L+ FD +ELEL+I G +ID++DW+ NT + D++IV +WFW AVE F
Sbjct: 1429 FYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERF 1488
Query: 664 DEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIP 723
+ E+R RLLQFVTG+S +P +GF +L+G+ GPR F + + T LP+AHTCFNR+D+P
Sbjct: 1489 NNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKIT-ALPRAHTCFNRLDLP 1547
Query: 724 PYESYEKLYEKLLTAIEETCGFAVE 748
PY S+ LYEKLLTA+EET F +E
Sbjct: 1548 PYPSFSMLYEKLLTAVEETSTFGLE 1572
Score = 73.6 bits (179), Expect = 6e-13
Identities = 65/218 (29%), Positives = 88/218 (40%), Gaps = 48/218 (22%)
Query: 156 DNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPAS------------------EYSS 197
D LP WE R + GRI Y++H+ RTT W+RPT P + Y S
Sbjct: 806 DEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQS 865
Query: 198 PGRPLSCFVDENTPISGTNGAT-CGQSSDPRLAERRVRSQR---HRNYMSRTHL--HTPP 251
R ++ P TN G+ +D A R + H SR L +PP
Sbjct: 866 IRRTMT----NERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPP 921
Query: 252 --------------DLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP--RDLS---NIN 292
P Y T + + T+ T H R RDL N+
Sbjct: 922 VKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMI-TKVRRDTHHFERYQHNRDLVGFLNMF 980
Query: 293 CEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
+ LP GWE+++ G+ +FVDHN+RTT F DPRL
Sbjct: 981 ANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
Score = 44.3 bits (103), Expect = 4e-04
Identities = 25/68 (36%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 282 PRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQ 341
P V +D+S + LPP WE R + GR+++VDH NRTT + P + VL R
Sbjct: 793 PSVRQDVSRYQRVDEA-LPPNWEARIDSHGRIFYVDHVNRTTTWQRP-TAPPAPQVLQRS 850
Query: 342 NQLKDQQQ 349
N ++ +Q
Sbjct: 851 NSIQQMEQ 858
Score = 32.7 bits (73), Expect = 1.3
Identities = 12/34 (35%), Positives = 22/34 (64%)
Query: 252 DLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP 285
+LP G+E + QG+ +F+ + +T+ DPR+P
Sbjct: 986 ELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLP 1019
Score = 31.2 bits (69), Expect = 3.7
Identities = 16/49 (32%), Positives = 24/49 (48%), Gaps = 4/49 (8%)
Query: 158 DLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFV 206
+LP GWE + G+ +++H +RTT + P P RP S V
Sbjct: 986 ELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQS----SRPTSALV 1030
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 359 bits (921), Expect = 6e-99
Identities = 182/385 (47%), Positives = 253/385 (65%), Gaps = 5/385 (1%)
Query: 368 YKRDLVQKLKILRQELSQQQPQAGHCRIE--VSREEIFEESYRQVMKMRPKDLWK-RLMI 424
Y+RD KL+ ++L + G +I+ + R+ + E ++ QVM K+L + +L +
Sbjct: 1223 YRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYV 1282
Query: 425 KFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFH 484
F GEEGLDY G +RE+ +LLS E+ NPYYGLF+YS +D YT+QI+P SA HL +F
Sbjct: 1283 TFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFR 1342
Query: 485 FVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGV 544
F GRI+G+A+ H + +D FT PFYK LL L D+E +D + H SL W+ +N+IT +
Sbjct: 1343 FSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI 1402
Query: 545 LDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKG 604
LD TF V +G++ + ELK G + V E+NKKEY+ V WR RG+ Q AL +G
Sbjct: 1403 LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRG 1462
Query: 605 FNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSN-IVKWFWKAVEFF 663
F EV+ L+ FD +ELEL+I G +ID+NDW+ NT + D + +++WFW AVE F
Sbjct: 1463 FYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERF 1522
Query: 664 DEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIP 723
+ E+R RLLQFVTG+S VP +GF AL+G+ G R F I + T +LP+AHTCFNR+D+P
Sbjct: 1523 NNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKIT-SLPRAHTCFNRLDLP 1581
Query: 724 PYESYEKLYEKLLTAIEETCGFAVE 748
PY SY LYEKLLTA+EET F +E
Sbjct: 1582 PYPSYSMLYEKLLTAVEETSTFGLE 1606
Score = 46.6 bits (109), Expect = 8e-05
Identities = 18/38 (47%), Positives = 25/38 (65%)
Query: 156 DNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPAS 193
D LP WE R + GR+ Y++H+ RTT W+RPT A+
Sbjct: 828 DEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAAT 865
Score = 46.2 bits (108), Expect = 1e-04
Identities = 18/32 (56%), Positives = 23/32 (71%)
Query: 299 LPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
LP GWEI+ G+ +FVDHN+R T F DPR+
Sbjct: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
Score = 45.8 bits (107), Expect = 1e-04
Identities = 31/84 (36%), Positives = 40/84 (47%), Gaps = 8/84 (9%)
Query: 254 PEGYEQRTT-----QQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNT 308
PEG E ++G+ LH VS R P +E PLPP WE R
Sbjct: 784 PEGLESPVAGPSNRREGECPILHNSQPVSQLPSLR-PEHHHYPTIDE--PLPPNWEARID 840
Query: 309 ATGRVYFVDHNNRTTQFTDPRLSA 332
+ GRV++VDH NRTT + P +A
Sbjct: 841 SHGRVFYVDHVNRTTTWQRPTAAA 864
Score = 36.6 bits (83), Expect = 0.087
Identities = 18/54 (33%), Positives = 34/54 (62%), Gaps = 2/54 (3%)
Query: 234 RSQRHRNYMSRTHLH--TPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP 285
R Q +R+ ++ ++ T +LP G+E +T QQG+ +F+ + +T+ DPR+P
Sbjct: 999 RYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIP 1052
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 332 bits (852), Expect = 6e-91
Identities = 175/374 (46%), Positives = 232/374 (62%), Gaps = 3/374 (0%)
Query: 371 DLVQKLKILRQELSQQQP--QAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRG 428
D K K RQEL + + + V R+ +FE+SYR++ + P+++ RL I F G
Sbjct: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEG 4052
Query: 429 EEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGR 488
EEG D GG+ REW ++S EM NP Y LF+ S D T INP S NP HLSYF FVGR
Sbjct: 4053 EEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGR 4112
Query: 489 IMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGV-LDH 547
I+ AV+ ++ FT FYK +LGKS+ DME D + LV++LEND++ + D
Sbjct: 4113 IVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDL 4172
Query: 548 TFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNE 607
TF E +G +LKPNG +I V EENKKEYV L R I Q A +GF E
Sbjct: 4173 TFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYE 4232
Query: 608 VIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEER 667
+IP+ L+ F E+ELEL+I GL ID++D K NT +S ++WFW+A+ FD+
Sbjct: 4233 IIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQAD 4292
Query: 668 RARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYES 727
RA+ LQFVTG+S+VPLQGF AL+G G + F IH+ D T+ LP AHTCFN++D+P YES
Sbjct: 4293 RAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYES 4352
Query: 728 YEKLYEKLLTAIEE 741
+EKL LL AI+E
Sbjct: 4353 FEKLRHMLLLAIQE 4366
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 266 bits (680), Expect = 5e-71
Identities = 148/350 (42%), Positives = 209/350 (59%), Gaps = 6/350 (1%)
Query: 397 VSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGL 456
V R+ IF S V K L + + ++F GEEG+ G V REW +LS+E++NP Y L
Sbjct: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYAL 615
Query: 457 FQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKS 516
F S D T Q N +S VNP+HL+YF F G+I+G+A+ H ++ FT FYK +LG
Sbjct: 616 FTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP 674
Query: 517 ITLDDMELVDPDLHNSLVWILENDITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVNE 575
+ D+ +DP+ +L WIL+NDI+ + L+ TF VE + +G + + LKP G SI V +
Sbjct: 675 VNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQ 734
Query: 576 ENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVN 635
NK EYV+L R R I+ Q A +GF+ IP L++ FDE ELEL++ G+ +IDV+
Sbjct: 735 NNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVS 794
Query: 636 DWKVNTR-LKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAG 694
DW NT + +++WFW+ VE +E R LLQFVTGSSRVP GF + G +G
Sbjct: 795 DWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSG 854
Query: 695 PRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCG 744
+ FTI + N LP + TC N + +P Y S E L ++LL A+ CG
Sbjct: 855 LQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALH--CG 902
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 194 bits (493), Expect = 3e-49
Identities = 127/398 (31%), Positives = 204/398 (51%), Gaps = 35/398 (8%)
Query: 374 QKLKILRQEL-----SQQQPQAG--HCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKF 426
Q + I RQ L +Q+P ++V R + +S ++ + R DL K+L + F
Sbjct: 391 QMINIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELTRKRA-DLKKKLKVTF 449
Query: 427 RGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFV 486
GE GLD GG+ +EW LL ++ +P YG+F Y +D + S+ ++ S F V
Sbjct: 450 VGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDS----HCHWFSSFKCDNYSEFRLV 505
Query: 487 GRIMGMAVFHGHYIDGGFTLPFYKQLLGK--------------SITLDDMELVDPDLHNS 532
G +MG+AV++ +D F YK+LL ++T+DD+ + P+L +
Sbjct: 506 GILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHG 565
Query: 533 LVWIL--ENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRF 590
L +L E ++ TF V +G I + LKP G I V +N+KEYV+LY ++
Sbjct: 566 LSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLL 625
Query: 591 LRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDS 650
+ I QF A GF+ V + L +E+E+++CG +D++ + +T+
Sbjct: 626 NKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTD 685
Query: 651 NIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNL 710
+K+FW V F + + +LL F TGS RVP+ G L F I + + TN L
Sbjct: 686 LTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLN-------FKISKNETSTNCL 738
Query: 711 PKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 748
P AHTCFN++ +PPY+S + L +KL+ I + GF +E
Sbjct: 739 PVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE 776
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 193 bits (490), Expect = 6e-49
Identities = 123/373 (32%), Positives = 198/373 (53%), Gaps = 19/373 (5%)
Query: 383 LSQQQPQAGHCRIEVSREEIFEESY---RQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAR 439
L Q Q + R++V R+ I +++ + P DL K+L ++F GE+G+D GGV++
Sbjct: 510 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 569
Query: 440 EWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHY 499
E+ L+ E+ NP G+F Y + NP S E F +G ++G+A+++
Sbjct: 570 EFFQLVVEEIFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCI 625
Query: 500 IDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILE--NDITGVLDHTFCVEH-NAY 556
+D F + Y++L+GK T D+ P L+ SL +LE ++ + TF + + +
Sbjct: 626 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 685
Query: 557 GEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLK- 615
G + ++LK NG IP+ EN+KE+V LY ++ + +E QF A ++GF+ V + LK
Sbjct: 686 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 745
Query: 616 TFDEKELELIICGLGKIDVNDWKVNTRLK-HCTPDSNIVKWFWKAVEFFDEERRARLLQF 674
F +E+EL+ICG +D + T T DS +++ FW+ V F +E++ LQF
Sbjct: 746 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 805
Query: 675 VTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEK 734
TG+ R P+ G G I + T LP +HTCFN + +P Y S EKL E+
Sbjct: 806 TTGTDRAPV-------GGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 858
Query: 735 LLTAIEETCGFAV 747
LL AI GF +
Sbjct: 859 LLKAITYAKGFGM 871
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 193 bits (490), Expect = 6e-49
Identities = 123/373 (32%), Positives = 198/373 (53%), Gaps = 19/373 (5%)
Query: 383 LSQQQPQAGHCRIEVSREEIFEESY---RQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAR 439
L Q Q + R++V R+ I +++ + P DL K+L ++F GE+G+D GGV++
Sbjct: 490 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 549
Query: 440 EWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHY 499
E+ L+ E+ NP G+F Y + NP S E F +G ++G+A+++
Sbjct: 550 EFFQLVVEEIFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCI 605
Query: 500 IDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILE--NDITGVLDHTFCVEH-NAY 556
+D F + Y++L+GK T D+ P L+ SL +LE ++ + TF + + +
Sbjct: 606 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 665
Query: 557 GEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLK- 615
G + ++LK NG IP+ EN+KE+V LY ++ + +E QF A ++GF+ V + LK
Sbjct: 666 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 725
Query: 616 TFDEKELELIICGLGKIDVNDWKVNTRLK-HCTPDSNIVKWFWKAVEFFDEERRARLLQF 674
F +E+EL+ICG +D + T T DS +++ FW+ V F +E++ LQF
Sbjct: 726 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 785
Query: 675 VTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEK 734
TG+ R P+ G G I + T LP +HTCFN + +P Y S EKL E+
Sbjct: 786 TTGTDRAPV-------GGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 838
Query: 735 LLTAIEETCGFAV 747
LL AI GF +
Sbjct: 839 LLKAITYAKGFGM 851
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 193 bits (490), Expect = 6e-49
Identities = 123/373 (32%), Positives = 198/373 (53%), Gaps = 19/373 (5%)
Query: 383 LSQQQPQAGHCRIEVSREEIFEESY---RQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAR 439
L Q Q + R++V R+ I +++ + P DL K+L ++F GE+G+D GGV++
Sbjct: 513 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 572
Query: 440 EWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHY 499
E+ L+ E+ NP G+F Y + NP S E F +G ++G+A+++
Sbjct: 573 EFFQLVVEEIFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCI 628
Query: 500 IDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILE--NDITGVLDHTFCVEH-NAY 556
+D F + Y++L+GK T D+ P L+ SL +LE ++ + TF + + +
Sbjct: 629 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 688
Query: 557 GEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLK- 615
G + ++LK NG IP+ EN+KE+V LY ++ + +E QF A ++GF+ V + LK
Sbjct: 689 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 748
Query: 616 TFDEKELELIICGLGKIDVNDWKVNTRLK-HCTPDSNIVKWFWKAVEFFDEERRARLLQF 674
F +E+EL+ICG +D + T T DS +++ FW+ V F +E++ LQF
Sbjct: 749 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 808
Query: 675 VTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEK 734
TG+ R P+ G G I + T LP +HTCFN + +P Y S EKL E+
Sbjct: 809 TTGTDRAPV-------GGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 861
Query: 735 LLTAIEETCGFAV 747
LL AI GF +
Sbjct: 862 LLKAITYAKGFGM 874
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 183 bits (465), Expect = 4e-46
Identities = 127/394 (32%), Positives = 197/394 (50%), Gaps = 34/394 (8%)
Query: 375 KLKILRQELSQQQPQAGHCRI--EVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGL 432
K+ ++EL Q + H ++ +VSR + E S + D K + F+ EE L
Sbjct: 442 KVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEAL 501
Query: 433 DYGGVAREWLYLLSHEMLNPYYGLF-QYSRDDIYTLQINPDSAVNPEHL--SYFHFVGRI 489
D+GG REW L+ + + LF ++S ++ + NP+ P HL + F GR+
Sbjct: 502 DWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPN---RPAHLRLKMYEFAGRL 558
Query: 490 MGMAVFH----GHY---IDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDIT 542
+G ++ G Y + FT F Q++G + E DP+ + S V + N+
Sbjct: 559 VGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDM 618
Query: 543 GVLDHTFCVE-HNAYGEIIQH-ELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLA 600
++ F E +N G++ + EL G PV NK Y+ L +R ++ +
Sbjct: 619 SEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEH 678
Query: 601 LQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPD--SNIVKWFWK 658
KG NE++P++LL FDE ELEL++CG G I V+D+K + + + +++WFW
Sbjct: 679 FLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWT 738
Query: 659 AVEFFDEERRARLLQFVTGSSRVPLQGFKAL----QGAAGPRLFTIHQIDACTNNLPKAH 714
V +E ARLLQF TGSS++P GF AL Q A P T LP AH
Sbjct: 739 VVSSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTHST----------LPTAH 788
Query: 715 TCFNRIDIPPYESYEKLYEKLLTAIEETC-GFAV 747
TCFN++ +P Y+SYE+++ L AI E C GF +
Sbjct: 789 TCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGM 822
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 176 bits (447), Expect = 5e-44
Identities = 112/355 (31%), Positives = 181/355 (50%), Gaps = 15/355 (4%)
Query: 397 VSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGL 456
V RE I ++ + K + D K L + F GE+ +D GGV +E+ L+ E+L+P YG+
Sbjct: 705 VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 764
Query: 457 FQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKS 516
F+Y D ++ S E FH +G I G+A+++ +D F L YK+LL K
Sbjct: 765 FRYYEDS----RLIWFSDKTFEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 820
Query: 517 ITLDDMELVDPDLHNSLVWIL---ENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPV 573
+LDD++ + PD+ S+ +L E+DI F + +G EL NG V
Sbjct: 821 PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAV 880
Query: 574 NEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKID 633
N++N++E+V YV++ F + + + F A GF++V +L F EL+ ++ G D
Sbjct: 881 NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYD 940
Query: 634 VNDWKVNTRLK-HCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGA 692
+ + NT K + +K FW+ E++ + L F+TGS R+P+ G K+L+
Sbjct: 941 WKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLK-- 998
Query: 693 AGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 747
I LP +HTCFN +D+P Y E L KL+ AI+ GF++
Sbjct: 999 -----LVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1048
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 176 bits (447), Expect = 5e-44
Identities = 112/355 (31%), Positives = 181/355 (50%), Gaps = 15/355 (4%)
Query: 397 VSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGL 456
V RE I ++ + K + D K L + F GE+ +D GGV +E+ L+ E+L+P YG+
Sbjct: 713 VRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGM 772
Query: 457 FQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKS 516
F+Y D ++ S E FH +G I G+A+++ +D F L YK+LL K
Sbjct: 773 FRYYEDS----RLIWFSDKTFEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKK 828
Query: 517 ITLDDMELVDPDLHNSLVWIL---ENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPV 573
+LDD++ + PD+ S+ +L E+DI F + +G EL NG V
Sbjct: 829 PSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAV 888
Query: 574 NEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKID 633
N++N++E+V YV++ F + + + F A GF++V +L F EL+ ++ G D
Sbjct: 889 NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYD 948
Query: 634 VNDWKVNTRLK-HCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGA 692
+ + NT K + +K FW+ E++ + L F+TGS R+P+ G K+L+
Sbjct: 949 WKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLK-- 1006
Query: 693 AGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 747
I LP +HTCFN +D+P Y E L KL+ AI+ GF++
Sbjct: 1007 -----LVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1056
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 169 bits (429), Expect = 7e-42
Identities = 118/377 (31%), Positives = 186/377 (49%), Gaps = 17/377 (4%)
Query: 380 RQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRG-----EEGLDY 434
+QE+ P + + R I+E++Y ++ DL KR+ + E G+D
Sbjct: 710 KQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDG 769
Query: 435 GGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAV 494
GG+ RE+L L NP G F+ + + + V +++F+GR++G A+
Sbjct: 770 GGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKAL 829
Query: 495 FHGHYIDGGFTLPFYKQLLGKSITLDDMEL--VDPDLHNSLVWI--LENDITGVLDHTFC 550
+ ++ F F +LLG S +D L +DP+++ +L+++ E+D+ L F
Sbjct: 830 YENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEE-LGLNFT 888
Query: 551 VEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIP 610
V +N GE ELK GK IPV N+ Y+ L ++R R I LA ++G V+
Sbjct: 889 VVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVS 948
Query: 611 QHLLKTFDEKELELIICGLG-KIDVNDWKVNTRLK-HCTPDSNIVKWFWKAVEFFDEERR 668
L+ FD++E++++I G I + D K T + D ++K FW+ VE F +E +
Sbjct: 949 LEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEK 1008
Query: 669 ARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESY 728
+LL+FVT SR PL GFK L A F IH + LP A TC N + +P +
Sbjct: 1009 RKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGSDLERLPTASTCMNLLKLPEFYDE 1063
Query: 729 EKLYEKLLTAIEETCGF 745
L KLL AIE GF
Sbjct: 1064 TLLRSKLLYAIECAAGF 1080
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,571,605
Number of Sequences: 37866
Number of extensions: 1481604
Number of successful extensions: 4218
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 95
Number of HSP's that attempted gapping in prelim test: 3509
Number of HSP's gapped (non-prelim): 457
length of query: 748
length of database: 18,247,518
effective HSP length: 110
effective length of query: 638
effective length of database: 14,082,258
effective search space: 8984480604
effective search space used: 8984480604
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.