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Search of human proteins with 27477109
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
(862 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 1793 0.0
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 1079 0.0
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 979 0.0
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 685 0.0
gi|114520609 neural precursor cell expressed, developmentally do... 526 e-149
gi|114520607 neural precursor cell expressed, developmentally do... 526 e-149
gi|222352183 neural precursor cell expressed, developmentally do... 523 e-148
gi|21361472 neural precursor cell expressed, developmentally dow... 523 e-148
gi|222352094 neural precursor cell expressed, developmentally do... 523 e-148
gi|222352092 neural precursor cell expressed, developmentally do... 523 e-148
gi|222352090 neural precursor cell expressed, developmentally do... 523 e-148
gi|222352088 neural precursor cell expressed, developmentally do... 523 e-148
gi|222352086 neural precursor cell expressed, developmentally do... 523 e-148
gi|222352084 neural precursor cell expressed, developmentally do... 523 e-148
gi|222352082 neural precursor cell expressed, developmentally do... 523 e-148
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 489 e-138
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 472 e-133
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 466 e-131
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 375 e-103
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 374 e-103
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 336 5e-92
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 298 1e-80
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 219 1e-56
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 202 8e-52
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 201 2e-51
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 201 2e-51
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 201 2e-51
gi|7657152 hect domain and RLD 3 [Homo sapiens] 184 4e-46
gi|35493952 ubiquitin protein ligase E3B [Homo sapiens] 182 1e-45
gi|35493959 ubiquitin protein ligase E3B [Homo sapiens] 182 1e-45
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 1793 bits (4643), Expect = 0.0
Identities = 862/862 (100%), Positives = 862/862 (100%)
Query: 1 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT 60
MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
Sbjct: 1 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT 60
Query: 61 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL 120
NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
Sbjct: 61 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL 120
Query: 121 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGS 180
QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGS
Sbjct: 121 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGS 180
Query: 181 DDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD 240
DDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD
Sbjct: 181 DDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD 240
Query: 241 GSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR 300
GSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR
Sbjct: 241 GSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR 300
Query: 301 VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ 360
VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ
Sbjct: 301 VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ 360
Query: 361 LQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT 420
LQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT
Sbjct: 361 LQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT 420
Query: 421 RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ 480
RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ
Sbjct: 421 RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ 480
Query: 481 IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF 540
IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF
Sbjct: 481 IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF 540
Query: 541 PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI 600
PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI
Sbjct: 541 PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI 600
Query: 601 GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDL 660
GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDL
Sbjct: 601 GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDL 660
Query: 661 EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF 720
EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF
Sbjct: 661 EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF 720
Query: 721 NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDN 780
NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDN
Sbjct: 721 NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDN 780
Query: 781 EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK 840
EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK
Sbjct: 781 EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK 840
Query: 841 SYEQLKEKLLFAIEETEGFGQE 862
SYEQLKEKLLFAIEETEGFGQE
Sbjct: 841 SYEQLKEKLLFAIEETEGFGQE 862
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 1079 bits (2790), Expect = 0.0
Identities = 547/910 (60%), Positives = 648/910 (71%), Gaps = 72/910 (7%)
Query: 19 QLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSK 78
QLQ+TV SAKLK KKNWFG + Y EV VDG+ KT K +++++PKW + LTV VTP +
Sbjct: 19 QLQVTVSSAKLKR-KKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTT 77
Query: 79 LHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLG-GDKEPTETIGDLSI 137
L F+VWSH+TLK+D LLG A +D+ + L +N KLE V L+L +K G+L++
Sbjct: 78 LEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLKLSLENKNGIAQTGELTV 137
Query: 138 CLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENR----- 192
LDGL +E E +TN ++ + +N D E T E +N
Sbjct: 138 VLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTST 197
Query: 193 RVSGNNSPSLSNGGFKPSRPP----RPSRPPPPTP--RRPA--SVNGSPSATSESDGSST 244
V + + NG PS P RP P P P PA +VNG S+ + +D +S
Sbjct: 198 LVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTVNGESSSFAPTDNASV 257
Query: 245 GSLPPTNTNTNTSEGATSGLI-----------------IPLT------------------ 269
P + S TS + IP T
Sbjct: 258 TGTPVVSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSN 317
Query: 270 ------ISGGSGPRP---LNPVTQAP-------LPPGWEQRVDQHGRVYYVDHVEKRTTW 313
+P ++PV Q LP GWEQR D HGR YYVDH + TTW
Sbjct: 318 SRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTW 377
Query: 314 DRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQF 373
+RP+PLPPGWERRVD+ R+YYVDH TRTTTWQRPT+ESVRN+EQWQ QR+QLQGAMQQF
Sbjct: 378 ERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQF 437
Query: 374 NQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQ 433
NQR++Y A+ + E DP GPLPPGWEKR DS RVYFVNHNT+ TQWEDPR+QG
Sbjct: 438 NQRYLYS-----ASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGL 492
Query: 434 LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNG-PQIAYVRDFKAKVQ 492
NE+PLPEGWE+R+T +G+ YFVDHN RTTT+ DPR GKS++ G PQIAY R F+ K+
Sbjct: 493 QNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLA 552
Query: 493 YFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVA 552
+FR+ CQ A+P H+KI V+R+TLFEDSFQQIM+ P DLRRRL+VIF GEEGLDYGG+A
Sbjct: 553 HFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLA 612
Query: 553 REWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGK 612
REWFFLLSHEVLNPMYCLFEYAGK+NYCLQINPAS INPDHL YF FIGRFIAMALFHGK
Sbjct: 613 REWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGK 672
Query: 613 FIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILG 672
FIDTGFSLPFYKR+L+K + +KDLESID EFYNSLIW+++NNIEEC LEMYFSVD EILG
Sbjct: 673 FIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILG 732
Query: 673 EIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYF 732
++ SHDLK G NILVTEENK+EYI ++ EWR SRGV+EQT+AF +GFNE++P Q+LQYF
Sbjct: 733 KVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYF 792
Query: 733 DAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTG 792
D KELEV+LCGMQE+DL DWQR+ +YRHY R SKQI+WFWQFVKE DNE RMRLLQFVTG
Sbjct: 793 DEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTG 852
Query: 793 TCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFA 852
TCRLP+GGFA+LMGSNGPQKFCIEKVGK+ WLPRSHTCFNRLDLPPYKSYEQLKEKLLFA
Sbjct: 853 TCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFA 912
Query: 853 IEETEGFGQE 862
IEETEGFGQE
Sbjct: 913 IEETEGFGQE 922
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 979 bits (2530), Expect = 0.0
Identities = 515/888 (57%), Positives = 631/888 (71%), Gaps = 44/888 (4%)
Query: 1 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGP--SPYVEVTVDG---QSKKTE 55
M+ + S + KSQL + V+SAK K + + P + YVEV VDG ++KKT
Sbjct: 1 MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQ---PRINSYVEVAVDGLPSETKKTG 57
Query: 56 KCNNTNSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEE 115
K ++ W + + + VT S L +VWS TL+++ LLGTA++++ LK+N K+E
Sbjct: 58 KRIGSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNE-LLGTASVNLSNVLKNNGGKMEN 116
Query: 116 VVVTLQLGGD-KEPTETIGDLSICLDGLQLESEVVTNGE--TTCSESASQNDDGSRSKDE 172
+ +TL L + K + G+L+I LDG ++ V NG T S+ S++ G+ E
Sbjct: 117 MQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPE 176
Query: 173 TR---VSTN--GSDDPEDAGAGENRRVS---GNNSPSLSNGGFKPSRPPRPSRPPPPTPR 224
R STN G +G + R + G SP SR +P + +
Sbjct: 177 NRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGAR------SRHRQPVKNSGHSGL 230
Query: 225 RPASVNGSPS-ATSESDGSSTG-SLPPTNTNTNTSEGATSGLIIPLTISGG-----SGPR 277
+VN P+ AT + S G + PP + T T+ L P T + G SG +
Sbjct: 231 ANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQ 290
Query: 278 PLNPVTQAP--LPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYY 335
L QAP LP GWEQR +GRVYYVDH K TTW+RP LPPGWE+R D GR YY
Sbjct: 291 QLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP--LPPGWEKRTDPRGRFYY 348
Query: 336 VDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDP 395
VDH TRTTTWQRPT E VRNYEQWQ QR+QLQGAMQ F+QRF+Y + +S S + DP
Sbjct: 349 VDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQS-----SSASTDHDP 403
Query: 396 LGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYF 455
LGPLPPGWEKR D NGRVY+VNHNTR TQWEDPR+QG + E LP GWEM++T +G+ YF
Sbjct: 404 LGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYF 462
Query: 456 VDHNRRTTTYIDPRTG-KSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRK 514
VDHN RTTT+ DPR G +S G AY R F+ K FRF C A+P H+KI+V+R+
Sbjct: 463 VDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQ 522
Query: 515 TLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYA 574
TLFEDSFQQIM+ P DLRRRL++I GEEGLDYGG+AREWFFLLSHEVLNPMYCLFEYA
Sbjct: 523 TLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYA 582
Query: 575 GKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLK 634
GK+NYCLQINPAS INPDHL YFRFIGRFIAMAL+HGKFIDTGF+LPFYKR+LNK LK
Sbjct: 583 GKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLK 642
Query: 635 DLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKE 694
DLESIDPEFYNS++W+KENN+EEC LE+YF D EILG++ +H+LK G +I VTEENKE
Sbjct: 643 DLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKE 702
Query: 695 EYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQR 754
EYI ++ +WR +RGVEEQT+AF +GFNE+ P ++L+YFD KELE++LCGMQEID++DWQ+
Sbjct: 703 EYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQK 762
Query: 755 HAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFC 814
IYRHY + SKQI WFWQ VKE+DNEKR+RLLQFVTGTCRLPVGGFA+L+GSNGPQKFC
Sbjct: 763 STIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFC 822
Query: 815 IEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 862
I+KVGKE WLPRSHTCFNRLDLPPYKSYEQL+EKLL+AIEETEGFGQE
Sbjct: 823 IDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE 870
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 685 bits (1767), Expect = 0.0
Identities = 315/430 (73%), Positives = 369/430 (85%), Gaps = 1/430 (0%)
Query: 434 LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTG-KSALDNGPQIAYVRDFKAKVQ 492
+ E LP GWEM++T +G+ YFVDHN RTTT+ DPR G +S G AY R F+ K
Sbjct: 2 IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYH 61
Query: 493 YFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVA 552
FRF C A+P H+KI+V+R+TLFEDSFQQIM+ P DLRRRL++I GEEGLDYGG+A
Sbjct: 62 QFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIA 121
Query: 553 REWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGK 612
REWFFLLSHEVLNPMYCLFEYAGK+NYCLQINPAS INPDHL YFRFIGRFIAMAL+HGK
Sbjct: 122 REWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGK 181
Query: 613 FIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILG 672
FIDTGF+LPFYKR+LNK LKDLESIDPEFYNS++W+KENN+EEC LE+YF D EILG
Sbjct: 182 FIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILG 241
Query: 673 EIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYF 732
++ +H+LK G +I VTEENKEEYI ++ +WR +RGVEEQT+AF +GFNE+ P ++L+YF
Sbjct: 242 KVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYF 301
Query: 733 DAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTG 792
D KELE++LCGMQEID++DWQ+ IYRHY + SKQI WFWQ VKE+DNEKR+RLLQFVTG
Sbjct: 302 DEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTG 361
Query: 793 TCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFA 852
TCRLPVGGFA+L+GSNGPQKFCI+KVGKE WLPRSHTCFNRLDLPPYKSYEQL+EKLL+A
Sbjct: 362 TCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYA 421
Query: 853 IEETEGFGQE 862
IEETEGFGQE
Sbjct: 422 IEETEGFGQE 431
Score = 41.6 bits (96), Expect = 0.003
Identities = 20/36 (55%), Positives = 25/36 (69%), Gaps = 2/36 (5%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQ--RPTLES 352
LPPGWE + + G Y+VDH TRTTT++ RP ES
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFES 42
Score = 38.9 bits (89), Expect = 0.021
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 282 VTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEP 318
+ + LPPGWE + G Y+VDH + TT+ P P
Sbjct: 2 IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 38
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 526 bits (1356), Expect = e-149
Identities = 269/557 (48%), Positives = 364/557 (65%), Gaps = 26/557 (4%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFI 378
LPPGWE + D GR YYVDH +RTTTW +PT+++ E QL SQ Q
Sbjct: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQAT--VETSQLTSSQSSAGPQSQASTSD 407
Query: 379 YGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQ--GQLNE 436
G Q +Q E + G LP GWE R NGR +F++HNT+ T WEDPR + L
Sbjct: 408 SGQQ----VTQPSEIEQ-GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRG 462
Query: 437 K----------PLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRD 486
K PLP GWE R DG ++++HN + T + DPR A+ GP + Y RD
Sbjct: 463 KTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAI-TGPAVPYSRD 521
Query: 487 FKAKVQYFRFWCQ-QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQD-LRRRLWVIFPGEE 544
+K K ++FR + Q +P ++ + R T+ EDS+++IM D L+ RLW+ F GE+
Sbjct: 522 YKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEK 581
Query: 545 GLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRF 603
GLDYGGVAREWFFL+S E+ NP Y LFEY+ DNY LQINP S + N DHL YF+FIGR
Sbjct: 582 GLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRV 641
Query: 604 IAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMY 663
MA++HGK +D F PFYK +L+KP+ L D+ES+D E+YNSL W+ EN+ E DL
Sbjct: 642 AGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLR-- 699
Query: 664 FSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEI 723
F +D+E+ G+ H+LK G I+VT +NK+EYI +V +WR +++Q AF EGF E+
Sbjct: 700 FIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFEL 759
Query: 724 LPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEK 782
+PQ ++ FD ELE+L+CG+ ++D+NDW+ H Y++ Y+ + I WFW+ V +D+EK
Sbjct: 760 IPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEK 819
Query: 783 RMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSY 842
R+RLLQFVTGT R+P+ GFA+L GSNGPQ F +E+ G LPR+HTCFNRLDLPPY+S+
Sbjct: 820 RIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESF 879
Query: 843 EQLKEKLLFAIEETEGF 859
E+L +KL AIE T+GF
Sbjct: 880 EELWDKLQMAIENTQGF 896
Score = 75.1 bits (183), Expect = 3e-13
Identities = 68/232 (29%), Positives = 96/232 (41%), Gaps = 44/232 (18%)
Query: 274 SGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRI 333
SG N L PGW +DQ ++ ++ P PLPPGWE R D +GR
Sbjct: 155 SGSEDDNAEQAEELEPGWVV-LDQPDAACHLQQQQE------PSPLPPGWEERQDILGRT 207
Query: 334 YYVDHFTRTTTWQRPT-LESVRNYEQWQLQ---------RSQLQGAMQQFNQRFIYGNQD 383
YYV+H +R T W+RPT +++ + E +Q R Q+ + + R N +
Sbjct: 208 YYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWE 267
Query: 384 LF----ATSQSKEFDPLGPLPPGWEKRT----DSNGRVYFV------------NHNTR-- 421
+ AT S + P P + T + N R+ NH++R
Sbjct: 268 IIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRG 327
Query: 422 ----ITQWEDPRSQGQL-NEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
T E P L LP GWE + G Y+VDHN RTTT+ P
Sbjct: 328 SLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKP 379
Score = 73.9 bits (180), Expect = 6e-13
Identities = 38/102 (37%), Positives = 51/102 (50%), Gaps = 22/102 (21%)
Query: 274 SGPRPLNP--VTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPE-------------- 317
SG + P + Q LP GWE R +GR +++DH K TTW+ P
Sbjct: 408 SGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLD 467
Query: 318 ------PLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESV 353
PLPPGWE R GRI+Y++H + T W+ P LE+V
Sbjct: 468 TSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENV 509
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 526 bits (1356), Expect = e-149
Identities = 269/557 (48%), Positives = 364/557 (65%), Gaps = 26/557 (4%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFI 378
LPPGWE + D GR YYVDH +RTTTW +PT+++ E QL SQ Q
Sbjct: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQAT--VETSQLTSSQSSAGPQSQASTSD 754
Query: 379 YGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQ--GQLNE 436
G Q +Q E + G LP GWE R NGR +F++HNT+ T WEDPR + L
Sbjct: 755 SGQQ----VTQPSEIEQ-GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRG 809
Query: 437 K----------PLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRD 486
K PLP GWE R DG ++++HN + T + DPR A+ GP + Y RD
Sbjct: 810 KTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAI-TGPAVPYSRD 868
Query: 487 FKAKVQYFRFWCQ-QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQD-LRRRLWVIFPGEE 544
+K K ++FR + Q +P ++ + R T+ EDS+++IM D L+ RLW+ F GE+
Sbjct: 869 YKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEK 928
Query: 545 GLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRF 603
GLDYGGVAREWFFL+S E+ NP Y LFEY+ DNY LQINP S + N DHL YF+FIGR
Sbjct: 929 GLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRV 988
Query: 604 IAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMY 663
MA++HGK +D F PFYK +L+KP+ L D+ES+D E+YNSL W+ EN+ E DL
Sbjct: 989 AGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLR-- 1046
Query: 664 FSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEI 723
F +D+E+ G+ H+LK G I+VT +NK+EYI +V +WR +++Q AF EGF E+
Sbjct: 1047 FIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFEL 1106
Query: 724 LPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEK 782
+PQ ++ FD ELE+L+CG+ ++D+NDW+ H Y++ Y+ + I WFW+ V +D+EK
Sbjct: 1107 IPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEK 1166
Query: 783 RMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSY 842
R+RLLQFVTGT R+P+ GFA+L GSNGPQ F +E+ G LPR+HTCFNRLDLPPY+S+
Sbjct: 1167 RIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESF 1226
Query: 843 EQLKEKLLFAIEETEGF 859
E+L +KL AIE T+GF
Sbjct: 1227 EELWDKLQMAIENTQGF 1243
Score = 73.9 bits (180), Expect = 6e-13
Identities = 38/102 (37%), Positives = 51/102 (50%), Gaps = 22/102 (21%)
Query: 274 SGPRPLNP--VTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPE-------------- 317
SG + P + Q LP GWE R +GR +++DH K TTW+ P
Sbjct: 755 SGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLD 814
Query: 318 ------PLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESV 353
PLPPGWE R GRI+Y++H + T W+ P LE+V
Sbjct: 815 TSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENV 856
Score = 73.6 bits (179), Expect = 8e-13
Identities = 74/260 (28%), Positives = 104/260 (40%), Gaps = 54/260 (20%)
Query: 255 NTSEGATSGLIIPLTISGGSGP---------RPLNPVTQAPLPPGWEQRVDQHGRVYYVD 305
N S+G S L+I SG G R PGW +DQ ++
Sbjct: 475 NCSKGGPSQLLIKFA-SGNEGKVDNLSRDSNRDCTNELSNSCKPGWVV-LDQPDAACHLQ 532
Query: 306 HVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPT-LESVRNYEQWQLQ-- 362
++ P PLPPGWE R D +GR YYV+H +R T W+RPT +++ + E +Q
Sbjct: 533 QQQE------PSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ 586
Query: 363 -------RSQLQGAMQQFNQRFIYGNQDLF----ATSQSKEFDPLGPLPPGWEKRT---- 407
R Q+ + + R N ++ AT S + P P + T
Sbjct: 587 AQRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAE 646
Query: 408 DSNGRVYFV------------NHNTR------ITQWEDPRSQGQL-NEKPLPEGWEMRFT 448
+ N R+ NH++R T E P L LP GWE +
Sbjct: 647 ELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQD 706
Query: 449 VDGIPYFVDHNRRTTTYIDP 468
G Y+VDHN RTTT+ P
Sbjct: 707 ERGRSYYVDHNSRTTTWTKP 726
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 523 bits (1346), Expect = e-148
Identities = 276/591 (46%), Positives = 367/591 (62%), Gaps = 56/591 (9%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLE------------SVRNYEQWQLQRSQ- 365
LP GWE R D GR YYV+H RTTTW RP ++ S + + Q++R +
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 366 -----------LQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP-----------LPPGW 403
L+GA +R + +D + QS + P LPPGW
Sbjct: 326 LSSPTVTLSAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGW 382
Query: 404 EKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK---PLPEGWEMRFTVDGI 452
E R NGR +F++HNT+ T WEDPR S+ LN PLP GWE R +DG
Sbjct: 383 EMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGR 442
Query: 453 PYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLA-MPQHIKITV 511
+++DHN + T + DPR A+ GP + Y R+FK K YFR ++ A +P ++ +
Sbjct: 443 TFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKL 501
Query: 512 TRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCL 570
R +FE+S+++IMS P L+ RLW+ F E+GLDYGGVAREWFFLLS E+ NP Y L
Sbjct: 502 HRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGL 561
Query: 571 FEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNK 629
FEY+ DNY LQINP S + N DHL YF FIGR +A+FHGK +D F PFYK +L K
Sbjct: 562 FEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGK 621
Query: 630 PVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVT 689
+ L D+ES+D E+YNSL W+ EN+ E DL F +D+E G+ DLKPNG I+VT
Sbjct: 622 QITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQTYQVDLKPNGSEIMVT 679
Query: 690 EENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDL 749
ENK EYI +V +WR V++Q AF EGF E+LP ++ FD ELE+L+CG+ ++D+
Sbjct: 680 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 739
Query: 750 NDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN 808
NDW++H+IY++ Y I WFW+ V +D EKR+RLLQFVTGT R+P+ GFA+L GSN
Sbjct: 740 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 799
Query: 809 GPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859
GPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 800 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 67.4 bits (163), Expect = 5e-11
Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375
P PLPPGWE +VDN+GR YYV+H RTT W RP+L V + +++ + A ++F
Sbjct: 71 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 130
Query: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404
R + ++DL E G +P WE
Sbjct: 131 R-RHISEDL-----EPEPSEGGDVPEPWE 153
Score = 58.2 bits (139), Expect = 3e-08
Identities = 24/43 (55%), Positives = 30/43 (69%)
Query: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428
+ SQ +E P PLPPGWE++ D+ GR Y+VNHN R TQW P
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 50.8 bits (120), Expect = 5e-06
Identities = 19/31 (61%), Positives = 23/31 (74%)
Query: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316
PLPPGWE++VD GR YYV+H + T W RP
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 38.9 bits (89), Expect = 0.021
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
+ H + D SQ Q L PLP GWE + G Y+V+HN RTT + P
Sbjct: 49 MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 523 bits (1346), Expect = e-148
Identities = 276/591 (46%), Positives = 367/591 (62%), Gaps = 56/591 (9%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLE------------SVRNYEQWQLQRSQ- 365
LP GWE R D GR YYV+H RTTTW RP ++ S + + Q++R +
Sbjct: 367 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 426
Query: 366 -----------LQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP-----------LPPGW 403
L+GA +R + +D + QS + P LPPGW
Sbjct: 427 LSSPTVTLSAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGW 483
Query: 404 EKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK---PLPEGWEMRFTVDGI 452
E R NGR +F++HNT+ T WEDPR S+ LN PLP GWE R +DG
Sbjct: 484 EMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGR 543
Query: 453 PYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLA-MPQHIKITV 511
+++DHN + T + DPR A+ GP + Y R+FK K YFR ++ A +P ++ +
Sbjct: 544 TFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKL 602
Query: 512 TRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCL 570
R +FE+S+++IMS P L+ RLW+ F E+GLDYGGVAREWFFLLS E+ NP Y L
Sbjct: 603 HRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGL 662
Query: 571 FEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNK 629
FEY+ DNY LQINP S + N DHL YF FIGR +A+FHGK +D F PFYK +L K
Sbjct: 663 FEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGK 722
Query: 630 PVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVT 689
+ L D+ES+D E+YNSL W+ EN+ E DL F +D+E G+ DLKPNG I+VT
Sbjct: 723 QITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQTYQVDLKPNGSEIMVT 780
Query: 690 EENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDL 749
ENK EYI +V +WR V++Q AF EGF E+LP ++ FD ELE+L+CG+ ++D+
Sbjct: 781 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 840
Query: 750 NDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN 808
NDW++H+IY++ Y I WFW+ V +D EKR+RLLQFVTGT R+P+ GFA+L GSN
Sbjct: 841 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 900
Query: 809 GPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859
GPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 901 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951
Score = 67.4 bits (163), Expect = 5e-11
Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375
P PLPPGWE +VDN+GR YYV+H RTT W RP+L V + +++ + A ++F
Sbjct: 192 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 251
Query: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404
R + ++DL E G +P WE
Sbjct: 252 R-RHISEDL-----EPEPSEGGDVPEPWE 274
Score = 58.2 bits (139), Expect = 3e-08
Identities = 24/43 (55%), Positives = 30/43 (69%)
Query: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428
+ SQ +E P PLPPGWE++ D+ GR Y+VNHN R TQW P
Sbjct: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 50.8 bits (120), Expect = 5e-06
Identities = 19/31 (61%), Positives = 23/31 (74%)
Query: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316
PLPPGWE++VD GR YYV+H + T W RP
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 38.9 bits (89), Expect = 0.021
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
+ H + D SQ Q L PLP GWE + G Y+V+HN RTT + P
Sbjct: 170 MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 523 bits (1346), Expect = e-148
Identities = 276/591 (46%), Positives = 367/591 (62%), Gaps = 56/591 (9%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLE------------SVRNYEQWQLQRSQ- 365
LP GWE R D GR YYV+H RTTTW RP ++ S + + Q++R +
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
Query: 366 -----------LQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP-----------LPPGW 403
L+GA +R + +D + QS + P LPPGW
Sbjct: 306 LSSPTVTLSAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGW 362
Query: 404 EKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK---PLPEGWEMRFTVDGI 452
E R NGR +F++HNT+ T WEDPR S+ LN PLP GWE R +DG
Sbjct: 363 EMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGR 422
Query: 453 PYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLA-MPQHIKITV 511
+++DHN + T + DPR A+ GP + Y R+FK K YFR ++ A +P ++ +
Sbjct: 423 TFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKL 481
Query: 512 TRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCL 570
R +FE+S+++IMS P L+ RLW+ F E+GLDYGGVAREWFFLLS E+ NP Y L
Sbjct: 482 HRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGL 541
Query: 571 FEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNK 629
FEY+ DNY LQINP S + N DHL YF FIGR +A+FHGK +D F PFYK +L K
Sbjct: 542 FEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGK 601
Query: 630 PVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVT 689
+ L D+ES+D E+YNSL W+ EN+ E DL F +D+E G+ DLKPNG I+VT
Sbjct: 602 QITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQTYQVDLKPNGSEIMVT 659
Query: 690 EENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDL 749
ENK EYI +V +WR V++Q AF EGF E+LP ++ FD ELE+L+CG+ ++D+
Sbjct: 660 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 719
Query: 750 NDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN 808
NDW++H+IY++ Y I WFW+ V +D EKR+RLLQFVTGT R+P+ GFA+L GSN
Sbjct: 720 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 779
Query: 809 GPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859
GPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 780 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
Score = 67.4 bits (163), Expect = 5e-11
Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375
P PLPPGWE +VDN+GR YYV+H RTT W RP+L V + +++ + A ++F
Sbjct: 71 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 130
Query: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404
R + ++DL E G +P WE
Sbjct: 131 R-RHISEDL-----EPEPSEGGDVPEPWE 153
Score = 58.2 bits (139), Expect = 3e-08
Identities = 24/43 (55%), Positives = 30/43 (69%)
Query: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428
+ SQ +E P PLPPGWE++ D+ GR Y+VNHN R TQW P
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 50.8 bits (120), Expect = 5e-06
Identities = 19/31 (61%), Positives = 23/31 (74%)
Query: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316
PLPPGWE++VD GR YYV+H + T W RP
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 38.9 bits (89), Expect = 0.021
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
+ H + D SQ Q L PLP GWE + G Y+V+HN RTT + P
Sbjct: 49 MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 523 bits (1346), Expect = e-148
Identities = 276/591 (46%), Positives = 367/591 (62%), Gaps = 56/591 (9%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLE------------SVRNYEQWQLQRSQ- 365
LP GWE R D GR YYV+H RTTTW RP ++ S + + Q++R +
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
Query: 366 -----------LQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP-----------LPPGW 403
L+GA +R + +D + QS + P LPPGW
Sbjct: 306 LSSPTVTLSAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGW 362
Query: 404 EKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK---PLPEGWEMRFTVDGI 452
E R NGR +F++HNT+ T WEDPR S+ LN PLP GWE R +DG
Sbjct: 363 EMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGR 422
Query: 453 PYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLA-MPQHIKITV 511
+++DHN + T + DPR A+ GP + Y R+FK K YFR ++ A +P ++ +
Sbjct: 423 TFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKL 481
Query: 512 TRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCL 570
R +FE+S+++IMS P L+ RLW+ F E+GLDYGGVAREWFFLLS E+ NP Y L
Sbjct: 482 HRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGL 541
Query: 571 FEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNK 629
FEY+ DNY LQINP S + N DHL YF FIGR +A+FHGK +D F PFYK +L K
Sbjct: 542 FEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGK 601
Query: 630 PVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVT 689
+ L D+ES+D E+YNSL W+ EN+ E DL F +D+E G+ DLKPNG I+VT
Sbjct: 602 QITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQTYQVDLKPNGSEIMVT 659
Query: 690 EENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDL 749
ENK EYI +V +WR V++Q AF EGF E+LP ++ FD ELE+L+CG+ ++D+
Sbjct: 660 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 719
Query: 750 NDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN 808
NDW++H+IY++ Y I WFW+ V +D EKR+RLLQFVTGT R+P+ GFA+L GSN
Sbjct: 720 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 779
Query: 809 GPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859
GPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 780 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
Score = 67.4 bits (163), Expect = 5e-11
Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375
P PLPPGWE +VDN+GR YYV+H RTT W RP+L V + +++ + A ++F
Sbjct: 71 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 130
Query: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404
R + ++DL E G +P WE
Sbjct: 131 R-RHISEDL-----EPEPSEGGDVPEPWE 153
Score = 58.2 bits (139), Expect = 3e-08
Identities = 24/43 (55%), Positives = 30/43 (69%)
Query: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428
+ SQ +E P PLPPGWE++ D+ GR Y+VNHN R TQW P
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 50.8 bits (120), Expect = 5e-06
Identities = 19/31 (61%), Positives = 23/31 (74%)
Query: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316
PLPPGWE++VD GR YYV+H + T W RP
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 38.9 bits (89), Expect = 0.021
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
+ H + D SQ Q L PLP GWE + G Y+V+HN RTT + P
Sbjct: 49 MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 523 bits (1346), Expect = e-148
Identities = 276/591 (46%), Positives = 367/591 (62%), Gaps = 56/591 (9%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLE------------SVRNYEQWQLQRSQ- 365
LP GWE R D GR YYV+H RTTTW RP ++ S + + Q++R +
Sbjct: 359 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 418
Query: 366 -----------LQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP-----------LPPGW 403
L+GA +R + +D + QS + P LPPGW
Sbjct: 419 LSSPTVTLSAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGW 475
Query: 404 EKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK---PLPEGWEMRFTVDGI 452
E R NGR +F++HNT+ T WEDPR S+ LN PLP GWE R +DG
Sbjct: 476 EMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGR 535
Query: 453 PYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLA-MPQHIKITV 511
+++DHN + T + DPR A+ GP + Y R+FK K YFR ++ A +P ++ +
Sbjct: 536 TFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKL 594
Query: 512 TRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCL 570
R +FE+S+++IMS P L+ RLW+ F E+GLDYGGVAREWFFLLS E+ NP Y L
Sbjct: 595 HRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGL 654
Query: 571 FEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNK 629
FEY+ DNY LQINP S + N DHL YF FIGR +A+FHGK +D F PFYK +L K
Sbjct: 655 FEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGK 714
Query: 630 PVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVT 689
+ L D+ES+D E+YNSL W+ EN+ E DL F +D+E G+ DLKPNG I+VT
Sbjct: 715 QITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQTYQVDLKPNGSEIMVT 772
Query: 690 EENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDL 749
ENK EYI +V +WR V++Q AF EGF E+LP ++ FD ELE+L+CG+ ++D+
Sbjct: 773 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 832
Query: 750 NDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN 808
NDW++H+IY++ Y I WFW+ V +D EKR+RLLQFVTGT R+P+ GFA+L GSN
Sbjct: 833 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 892
Query: 809 GPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859
GPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 893 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 943
Score = 67.4 bits (163), Expect = 5e-11
Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375
P PLPPGWE +VDN+GR YYV+H RTT W RP+L V + +++ + A ++F
Sbjct: 184 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 243
Query: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404
R + ++DL E G +P WE
Sbjct: 244 R-RHISEDL-----EPEPSEGGDVPEPWE 266
Score = 58.2 bits (139), Expect = 3e-08
Identities = 24/43 (55%), Positives = 30/43 (69%)
Query: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428
+ SQ +E P PLPPGWE++ D+ GR Y+VNHN R TQW P
Sbjct: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 50.8 bits (120), Expect = 5e-06
Identities = 19/31 (61%), Positives = 23/31 (74%)
Query: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316
PLPPGWE++VD GR YYV+H + T W RP
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 38.9 bits (89), Expect = 0.021
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
+ H + D SQ Q L PLP GWE + G Y+V+HN RTT + P
Sbjct: 162 MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 523 bits (1346), Expect = e-148
Identities = 276/591 (46%), Positives = 367/591 (62%), Gaps = 56/591 (9%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLE------------SVRNYEQWQLQRSQ- 365
LP GWE R D GR YYV+H RTTTW RP ++ S + + Q++R +
Sbjct: 379 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 438
Query: 366 -----------LQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP-----------LPPGW 403
L+GA +R + +D + QS + P LPPGW
Sbjct: 439 LSSPTVTLSAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGW 495
Query: 404 EKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK---PLPEGWEMRFTVDGI 452
E R NGR +F++HNT+ T WEDPR S+ LN PLP GWE R +DG
Sbjct: 496 EMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGR 555
Query: 453 PYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLA-MPQHIKITV 511
+++DHN + T + DPR A+ GP + Y R+FK K YFR ++ A +P ++ +
Sbjct: 556 TFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKL 614
Query: 512 TRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCL 570
R +FE+S+++IMS P L+ RLW+ F E+GLDYGGVAREWFFLLS E+ NP Y L
Sbjct: 615 HRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGL 674
Query: 571 FEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNK 629
FEY+ DNY LQINP S + N DHL YF FIGR +A+FHGK +D F PFYK +L K
Sbjct: 675 FEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGK 734
Query: 630 PVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVT 689
+ L D+ES+D E+YNSL W+ EN+ E DL F +D+E G+ DLKPNG I+VT
Sbjct: 735 QITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQTYQVDLKPNGSEIMVT 792
Query: 690 EENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDL 749
ENK EYI +V +WR V++Q AF EGF E+LP ++ FD ELE+L+CG+ ++D+
Sbjct: 793 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 852
Query: 750 NDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN 808
NDW++H+IY++ Y I WFW+ V +D EKR+RLLQFVTGT R+P+ GFA+L GSN
Sbjct: 853 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 912
Query: 809 GPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859
GPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 913 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 963
Score = 67.4 bits (163), Expect = 5e-11
Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375
P PLPPGWE +VDN+GR YYV+H RTT W RP+L V + +++ + A ++F
Sbjct: 184 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 243
Query: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404
R + ++DL E G +P WE
Sbjct: 244 R-RHISEDL-----EPEPSEGGDVPEPWE 266
Score = 58.2 bits (139), Expect = 3e-08
Identities = 24/43 (55%), Positives = 30/43 (69%)
Query: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428
+ SQ +E P PLPPGWE++ D+ GR Y+VNHN R TQW P
Sbjct: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 50.8 bits (120), Expect = 5e-06
Identities = 19/31 (61%), Positives = 23/31 (74%)
Query: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316
PLPPGWE++VD GR YYV+H + T W RP
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 38.9 bits (89), Expect = 0.021
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
+ H + D SQ Q L PLP GWE + G Y+V+HN RTT + P
Sbjct: 162 MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 523 bits (1346), Expect = e-148
Identities = 276/591 (46%), Positives = 367/591 (62%), Gaps = 56/591 (9%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLE------------SVRNYEQWQLQRSQ- 365
LP GWE R D GR YYV+H RTTTW RP ++ S + + Q++R +
Sbjct: 387 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 446
Query: 366 -----------LQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP-----------LPPGW 403
L+GA +R + +D + QS + P LPPGW
Sbjct: 447 LSSPTVTLSAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGW 503
Query: 404 EKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK---PLPEGWEMRFTVDGI 452
E R NGR +F++HNT+ T WEDPR S+ LN PLP GWE R +DG
Sbjct: 504 EMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGR 563
Query: 453 PYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLA-MPQHIKITV 511
+++DHN + T + DPR A+ GP + Y R+FK K YFR ++ A +P ++ +
Sbjct: 564 TFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKL 622
Query: 512 TRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCL 570
R +FE+S+++IMS P L+ RLW+ F E+GLDYGGVAREWFFLLS E+ NP Y L
Sbjct: 623 HRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGL 682
Query: 571 FEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNK 629
FEY+ DNY LQINP S + N DHL YF FIGR +A+FHGK +D F PFYK +L K
Sbjct: 683 FEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGK 742
Query: 630 PVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVT 689
+ L D+ES+D E+YNSL W+ EN+ E DL F +D+E G+ DLKPNG I+VT
Sbjct: 743 QITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQTYQVDLKPNGSEIMVT 800
Query: 690 EENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDL 749
ENK EYI +V +WR V++Q AF EGF E+LP ++ FD ELE+L+CG+ ++D+
Sbjct: 801 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 860
Query: 750 NDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN 808
NDW++H+IY++ Y I WFW+ V +D EKR+RLLQFVTGT R+P+ GFA+L GSN
Sbjct: 861 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 920
Query: 809 GPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859
GPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 921 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 971
Score = 67.4 bits (163), Expect = 5e-11
Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375
P PLPPGWE +VDN+GR YYV+H RTT W RP+L V + +++ + A ++F
Sbjct: 192 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 251
Query: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404
R + ++DL E G +P WE
Sbjct: 252 R-RHISEDL-----EPEPSEGGDVPEPWE 274
Score = 58.2 bits (139), Expect = 3e-08
Identities = 24/43 (55%), Positives = 30/43 (69%)
Query: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428
+ SQ +E P PLPPGWE++ D+ GR Y+VNHN R TQW P
Sbjct: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 50.8 bits (120), Expect = 5e-06
Identities = 19/31 (61%), Positives = 23/31 (74%)
Query: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316
PLPPGWE++VD GR YYV+H + T W RP
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 38.9 bits (89), Expect = 0.021
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
+ H + D SQ Q L PLP GWE + G Y+V+HN RTT + P
Sbjct: 170 MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 523 bits (1346), Expect = e-148
Identities = 276/591 (46%), Positives = 367/591 (62%), Gaps = 56/591 (9%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLE------------SVRNYEQWQLQRSQ- 365
LP GWE R D GR YYV+H RTTTW RP ++ S + + Q++R +
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 366 -----------LQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP-----------LPPGW 403
L+GA +R + +D + QS + P LPPGW
Sbjct: 326 LSSPTVTLSAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGW 382
Query: 404 EKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK---PLPEGWEMRFTVDGI 452
E R NGR +F++HNT+ T WEDPR S+ LN PLP GWE R +DG
Sbjct: 383 EMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGR 442
Query: 453 PYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLA-MPQHIKITV 511
+++DHN + T + DPR A+ GP + Y R+FK K YFR ++ A +P ++ +
Sbjct: 443 TFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKL 501
Query: 512 TRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCL 570
R +FE+S+++IMS P L+ RLW+ F E+GLDYGGVAREWFFLLS E+ NP Y L
Sbjct: 502 HRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGL 561
Query: 571 FEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNK 629
FEY+ DNY LQINP S + N DHL YF FIGR +A+FHGK +D F PFYK +L K
Sbjct: 562 FEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGK 621
Query: 630 PVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVT 689
+ L D+ES+D E+YNSL W+ EN+ E DL F +D+E G+ DLKPNG I+VT
Sbjct: 622 QITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQTYQVDLKPNGSEIMVT 679
Query: 690 EENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDL 749
ENK EYI +V +WR V++Q AF EGF E+LP ++ FD ELE+L+CG+ ++D+
Sbjct: 680 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 739
Query: 750 NDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN 808
NDW++H+IY++ Y I WFW+ V +D EKR+RLLQFVTGT R+P+ GFA+L GSN
Sbjct: 740 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 799
Query: 809 GPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859
GPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 800 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 67.4 bits (163), Expect = 5e-11
Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375
P PLPPGWE +VDN+GR YYV+H RTT W RP+L V + +++ + A ++F
Sbjct: 71 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 130
Query: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404
R + ++DL E G +P WE
Sbjct: 131 R-RHISEDL-----EPEPSEGGDVPEPWE 153
Score = 58.2 bits (139), Expect = 3e-08
Identities = 24/43 (55%), Positives = 30/43 (69%)
Query: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428
+ SQ +E P PLPPGWE++ D+ GR Y+VNHN R TQW P
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 50.8 bits (120), Expect = 5e-06
Identities = 19/31 (61%), Positives = 23/31 (74%)
Query: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316
PLPPGWE++VD GR YYV+H + T W RP
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 38.9 bits (89), Expect = 0.021
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
+ H + D SQ Q L PLP GWE + G Y+V+HN RTT + P
Sbjct: 49 MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 523 bits (1346), Expect = e-148
Identities = 276/591 (46%), Positives = 367/591 (62%), Gaps = 56/591 (9%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLE------------SVRNYEQWQLQRSQ- 365
LP GWE R D GR YYV+H RTTTW RP ++ S + + Q++R +
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 366 -----------LQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP-----------LPPGW 403
L+GA +R + +D + QS + P LPPGW
Sbjct: 326 LSSPTVTLSAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGW 382
Query: 404 EKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK---PLPEGWEMRFTVDGI 452
E R NGR +F++HNT+ T WEDPR S+ LN PLP GWE R +DG
Sbjct: 383 EMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGR 442
Query: 453 PYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLA-MPQHIKITV 511
+++DHN + T + DPR A+ GP + Y R+FK K YFR ++ A +P ++ +
Sbjct: 443 TFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKL 501
Query: 512 TRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCL 570
R +FE+S+++IMS P L+ RLW+ F E+GLDYGGVAREWFFLLS E+ NP Y L
Sbjct: 502 HRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGL 561
Query: 571 FEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNK 629
FEY+ DNY LQINP S + N DHL YF FIGR +A+FHGK +D F PFYK +L K
Sbjct: 562 FEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGK 621
Query: 630 PVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVT 689
+ L D+ES+D E+YNSL W+ EN+ E DL F +D+E G+ DLKPNG I+VT
Sbjct: 622 QITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQTYQVDLKPNGSEIMVT 679
Query: 690 EENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDL 749
ENK EYI +V +WR V++Q AF EGF E+LP ++ FD ELE+L+CG+ ++D+
Sbjct: 680 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 739
Query: 750 NDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN 808
NDW++H+IY++ Y I WFW+ V +D EKR+RLLQFVTGT R+P+ GFA+L GSN
Sbjct: 740 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 799
Query: 809 GPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859
GPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 800 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 67.4 bits (163), Expect = 5e-11
Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375
P PLPPGWE +VDN+GR YYV+H RTT W RP+L V + +++ + A ++F
Sbjct: 71 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 130
Query: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404
R + ++DL E G +P WE
Sbjct: 131 R-RHISEDL-----EPEPSEGGDVPEPWE 153
Score = 58.2 bits (139), Expect = 3e-08
Identities = 24/43 (55%), Positives = 30/43 (69%)
Query: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428
+ SQ +E P PLPPGWE++ D+ GR Y+VNHN R TQW P
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 50.8 bits (120), Expect = 5e-06
Identities = 19/31 (61%), Positives = 23/31 (74%)
Query: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316
PLPPGWE++VD GR YYV+H + T W RP
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 38.9 bits (89), Expect = 0.021
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
+ H + D SQ Q L PLP GWE + G Y+V+HN RTT + P
Sbjct: 49 MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 489 bits (1260), Expect = e-138
Identities = 261/595 (43%), Positives = 362/595 (60%), Gaps = 56/595 (9%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESV------RNYEQWQLQRSQLQGAM-- 370
LP GWE R GRI Y++H TRTT W+RPT + R + + + + G
Sbjct: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGA 218
Query: 371 -------QQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRIT 423
+ +R + + S++ P LP G+E+RT G+VYF++ T ++
Sbjct: 219 TCGQSSDPRLAERRVRSQRHRNYMSRTHLHTP-PDLPEGYEQRTTQQGQVYFLHTQTGVS 277
Query: 424 QWEDPRSQGQLNE------KPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKS---A 474
W DPR L+ PLP GWE+R T G YFVDHN RTT + DPR +
Sbjct: 278 TWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLV 337
Query: 475 LDNGPQIA----------------------YVRDFKAKVQYFRFWCQQLAMPQ----HIK 508
L+ Q+ Y RD K++ R Q+L+ Q H +
Sbjct: 338 LNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILR---QELSQQQPQAGHCR 394
Query: 509 ITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMY 568
I V+R+ +FE+S++Q+M P+DL +RL + F GEEGLDYGGVAREW +LLSHE+LNP Y
Sbjct: 395 IEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYY 454
Query: 569 CLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILN 628
LF+Y+ D Y LQINP S +NP+HL YF F+GR + MA+FHG +ID GF+LPFYK++L
Sbjct: 455 GLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLG 514
Query: 629 KPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILV 688
K + L D+E +DP+ +NSL+W+ EN+I L+ F V+ GEI H+LKPNG +I V
Sbjct: 515 KSITLDDMELVDPDLHNSLVWILENDITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPV 573
Query: 689 TEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEID 748
EENK+EY+R+ WR RG+E Q A +GFNE++PQ L+ FD KELE+++CG+ +ID
Sbjct: 574 NEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKID 633
Query: 749 LNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN 808
+NDW+ + +H S + WFW+ V+ D E+R RLLQFVTG+ R+P+ GF L G+
Sbjct: 634 VNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAA 693
Query: 809 GPQKFCIEKVGK-ENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 862
GP+ F I ++ N LP++HTCFNR+D+PPY+SYE+L EKLL AIEET GF E
Sbjct: 694 GPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 748
Score = 85.1 bits (209), Expect = 3e-16
Identities = 98/378 (25%), Positives = 149/378 (39%), Gaps = 64/378 (16%)
Query: 19 QLQITVISAKLKENKKNWFGPSPYVEVTVDG--QSKKTEKCNNTNSPKWKQPLTVIVTPV 76
+L++TV+ AK K + P P+ +V VDG Q T+ NT PKW Q + +
Sbjct: 13 KLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKS 72
Query: 77 SKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLS 136
+ VW+H+ + G L L + +L++ G + L
Sbjct: 73 DSVTISVWNHKKIHKKQ--GAGFLGCVRLLSNAINRLKDT------GYQR--------LD 116
Query: 137 ICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSG 196
+C G +++ V +S + G + D +R+ N D E RR +
Sbjct: 117 LCKLGPN-DNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPD-----GWEERRTAS 170
Query: 197 NNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNT 256
L++ +R + RP RPAS SP G NT +
Sbjct: 171 GRIQYLNH----ITRTTQWERPT-----RPASEYSSP-------GRPLSCFVDENTPISG 214
Query: 257 SEGATSGLIIPLTISGGS--GPRPLNPV------TQAPLPPGWEQRVDQHGRVYYVDHVE 308
+ GAT G ++ R N + T LP G+EQR Q G+VY++
Sbjct: 215 TNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQT 274
Query: 309 KRTTWDRPE--------------PLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVR 354
+TW P PLPPGWE R GR+Y+VDH RTT + P L +
Sbjct: 275 GVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSA-- 332
Query: 355 NYEQWQLQRSQLQGAMQQ 372
N +++QL+ QQ
Sbjct: 333 NLHLVLNRQNQLKDQQQQ 350
Score = 48.1 bits (113), Expect = 3e-05
Identities = 39/134 (29%), Positives = 52/134 (38%), Gaps = 56/134 (41%)
Query: 390 SKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWE----------------------- 426
S+ FD LP GWE+R ++GR+ ++NH TR TQWE
Sbjct: 152 SRLFD--NDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDEN 209
Query: 427 ---------------DPR---------------SQGQLNEKP-LPEGWEMRFTVDGIPYF 455
DPR S+ L+ P LPEG+E R T G YF
Sbjct: 210 TPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYF 269
Query: 456 VDHNRRTTTYIDPR 469
+ +T+ DPR
Sbjct: 270 LHTQTGVSTWHDPR 283
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 472 bits (1215), Expect = e-133
Identities = 246/520 (47%), Positives = 329/520 (63%), Gaps = 40/520 (7%)
Query: 381 NQDLFATSQSKEFDPLG----PLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNE 436
N D+ + Q+ + P G LP G+E+RT G+VYF++ T ++ W DPR LN
Sbjct: 214 NPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNS 273
Query: 437 K------PLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRT-------------------- 470
PLP GWE+R TV G YFVDHN RTT + DPR
Sbjct: 274 VNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLP 333
Query: 471 --GKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQ--HIKITVTRKTLFEDSFQQIMS 526
G + P Y RD K++ R L PQ H +I V+R+ +FE+S++QIM
Sbjct: 334 SEGSLEDEELPAQRYERDLVQKLKVLRHELS-LQQPQAGHCRIEVSREEIFEESYRQIMK 392
Query: 527 FSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPA 586
P+DL++RL V F GEEGLDYGGVAREW +LL HE+LNP Y LF+Y+ + Y LQINP
Sbjct: 393 MRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPD 452
Query: 587 SYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNS 646
S INPDHL YF F+GR + +A+FHG +I+ GF++PFYK++L KP+ L DLES+DPE + S
Sbjct: 453 SSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKS 512
Query: 647 LIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLS 706
L+W+ EN+I L+ F V+ G I H+LKPNG N+ VTEENK+EY+R+ WR
Sbjct: 513 LVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFM 571
Query: 707 RGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSK 766
RG+E Q A +GFNE++PQ L+ FD KELE+++ G+ +IDLNDW+ + +H S
Sbjct: 572 RGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSN 631
Query: 767 QIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSN---GPQKFCIEKV-GKEN 822
+ WFWQ V+ D E+R RLLQFVTG+ R+P+ GF L GS GP+ F I + +
Sbjct: 632 IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTD 691
Query: 823 WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 862
LP++HTCFNR+D+PPY+SYE+L EKLL A+EET GF E
Sbjct: 692 NLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 731
Score = 70.5 bits (171), Expect = 6e-12
Identities = 71/307 (23%), Positives = 111/307 (36%), Gaps = 18/307 (5%)
Query: 19 QLQITVISAKLKENKKNWFGPSPYVEVTVDG--QSKKTEKCNNTNSPKWKQPLTVIVTPV 76
++++TV+ AK K + P P+ ++ VDG Q T+ NT PKW Q + V
Sbjct: 14 KIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKT 73
Query: 77 SKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLS 136
+ VW+H+ + G L L + +L++ P++T
Sbjct: 74 DSITISVWNHKKIHKK--QGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRG 131
Query: 137 ICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSG 196
+ LQ + T G +N+ T +G P E +
Sbjct: 132 QIVVSLQTRDRIGTGGSVVDCRGLLENEG-------TVYEDSGPGRPLSCFMEEPAPYTD 184
Query: 197 NNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGS-PSATSESDGSSTGSLPPTNTNTN 255
+ + G + P + R V GS + + G + LP
Sbjct: 185 STGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRT 244
Query: 256 TSEGATSGLIIPLTISGGSG---PRPLNPVT---QAPLPPGWEQRVDQHGRVYYVDHVEK 309
T +G L +S PR LN V PLPPGWE R GR+Y+VDH +
Sbjct: 245 TVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNR 304
Query: 310 RTTWDRP 316
T + P
Sbjct: 305 TTQFTDP 311
Score = 63.5 bits (153), Expect = 8e-10
Identities = 35/89 (39%), Positives = 46/89 (51%), Gaps = 15/89 (16%)
Query: 284 QAP-LPPGWEQRVDQHGRVYYVDHVEKRTTWDRPE--------------PLPPGWERRVD 328
Q+P LP G+EQR G+VY++ +TW P PLPPGWE R
Sbjct: 232 QSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRST 291
Query: 329 NMGRIYYVDHFTRTTTWQRPTLESVRNYE 357
GRIY+VDH RTT + P L + N++
Sbjct: 292 VSGRIYFVDHNNRTTQFTDPRLHHIMNHQ 320
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 466 bits (1199), Expect = e-131
Identities = 246/551 (44%), Positives = 338/551 (61%), Gaps = 36/551 (6%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRF- 377
LP G+E+R G++Y++ T +TW P + S + G F F
Sbjct: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS---------PSGTIPGGDAAFLYEFL 286
Query: 378 IYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEK 437
+ G+ S D LGPLPPGWE R+ +GR+YFV+HN R TQ+ DPR +N +
Sbjct: 287 LQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQ 346
Query: 438 PLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFW 497
+++ +P P G + P Y RD K++ R
Sbjct: 347 -----CQLKEPSQPLPL-------------PSEGSLEDEELPAQRYERDLVQKLKVLRHE 388
Query: 498 CQQLAMPQ--HIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREW 555
L PQ H +I V+R+ +FE+S++QIM P+DL++RL V F GEEGLDYGGVAREW
Sbjct: 389 L-SLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREW 447
Query: 556 FFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFID 615
+LL HE+LNP Y LF+Y+ + Y LQINP S INPDHL YF F+GR + +A+FHG +I+
Sbjct: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYIN 507
Query: 616 TGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIK 675
GF++PFYK++L KP+ L DLES+DPE + SL+W+ EN+I L+ F V+ G I
Sbjct: 508 GGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHNAFGRIL 566
Query: 676 SHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAK 735
H+LKPNG N+ VTEENK+EY+R+ WR RG+E Q A +GFNE++PQ L+ FD K
Sbjct: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626
Query: 736 ELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCR 795
ELE+++ G+ +IDLNDW+ + +H S + WFWQ V+ D E+R RLLQFVTG+ R
Sbjct: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTR 686
Query: 796 LPVGGFADLMGSN---GPQKFCIEKV-GKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLF 851
+P+ GF L GS GP+ F I + + LP++HTCFNR+D+PPY+SYE+L EKLL
Sbjct: 687 VPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLT 746
Query: 852 AIEETEGFGQE 862
A+EET GF E
Sbjct: 747 AVEETCGFAVE 757
Score = 75.1 bits (183), Expect = 3e-13
Identities = 73/326 (22%), Positives = 120/326 (36%), Gaps = 30/326 (9%)
Query: 19 QLQITVISAKLKENKKNWFGPSPYVEVTVDG--QSKKTEKCNNTNSPKWKQPLTVIVTPV 76
++++TV+ AK K + P P+ ++ VDG Q T+ NT PKW Q + V
Sbjct: 14 KIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKT 73
Query: 77 SKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLS 136
+ VW+H+ + G L L + +L++ P++T
Sbjct: 74 DSITISVWNHKKIHKKQ--GAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRG 131
Query: 137 ICLDGLQLESEVVTNGETTCSESASQND------------------DGSRSKDETRVSTN 178
+ LQ + T G +N+ + + D T +
Sbjct: 132 QIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAG 191
Query: 179 GSDDPEDAGAGENRRVSGNN--SPSLSNGGFKPSRPPRPSRPP--PPTPRRPASVNGSPS 234
G + +++R+ +P + P P + P P + +V G
Sbjct: 192 GGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVY 251
Query: 235 ATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGG-SGPRPLNPVT---QAPLPPG 290
G ST P + + T G + + + G S PR LN V PLPPG
Sbjct: 252 FLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPG 311
Query: 291 WEQRVDQHGRVYYVDHVEKRTTWDRP 316
WE R GR+Y+VDH + T + P
Sbjct: 312 WEVRSTVSGRIYFVDHNNRTTQFTDP 337
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 375 bits (962), Expect = e-103
Identities = 190/385 (49%), Positives = 259/385 (67%), Gaps = 6/385 (1%)
Query: 483 YVRDFKAKVQYFRFWCQQLAM---PQHIKITVTRKTLFEDSFQQIMSFSPQDLRR-RLWV 538
Y RDF+AK++ F + P IK+ + R L E +F Q+M++S ++L+R +L+V
Sbjct: 1223 YRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYV 1282
Query: 539 IFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFR 598
F GEEGLDY G +RE+FFLLS E+ NP Y LFEY+ D Y +QI+P S +HL++FR
Sbjct: 1283 TFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFR 1342
Query: 599 FIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEEC 658
F GR + +AL H +D F+ PFYK +L P L DLE +D EF+ SL W+K+NNI +
Sbjct: 1343 FSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI 1402
Query: 659 DLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFE 718
L++ F+V++E+ G++ +LK G N VTE+NK+EYI + +WR+ RGV +QT+A
Sbjct: 1403 -LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVR 1461
Query: 719 GFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYR-HYARTSKQIMWFWQFVKE 777
GF E++ + + FDA+ELE+++ G EIDLNDW+ + YR Y I WFW V+
Sbjct: 1462 GFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVER 1521
Query: 778 IDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLP 837
+NE+R+RLLQFVTGT +P GFA L GSNG ++FCIEK GK LPR+HTCFNRLDLP
Sbjct: 1522 FNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLP 1581
Query: 838 PYKSYEQLKEKLLFAIEETEGFGQE 862
PY SY L EKLL A+EET FG E
Sbjct: 1582 PYPSYSMLYEKLLTAVEETSTFGLE 1606
Score = 69.3 bits (168), Expect = 1e-11
Identities = 35/76 (46%), Positives = 48/76 (63%), Gaps = 5/76 (6%)
Query: 317 EPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQR 376
EPLPP WE R+D+ GR++YVDH RTTTWQRPT + + ++RS M+Q N+R
Sbjct: 829 EPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPD----GMRRSGSIQQMEQLNRR 884
Query: 377 FIYGNQDLFATSQSKE 392
+ Q AT +S+E
Sbjct: 885 Y-QNIQRTIATERSEE 899
Score = 65.1 bits (157), Expect = 3e-10
Identities = 57/200 (28%), Positives = 80/200 (40%), Gaps = 19/200 (9%)
Query: 165 DGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFK--PSRPPRPSRPPPPT 222
+G+R TR S+ S A E+ S + N F+ P P P T
Sbjct: 709 NGNRFASHTRFSSVDS-----AKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPEST 763
Query: 223 PRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLN-- 280
+ + + + S G P +N EG L +S RP +
Sbjct: 764 NGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHH 823
Query: 281 -PVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP--EPLPPGWER-----RVDNMGR 332
P PLPP WE R+D HGRV+YVDHV + TTW RP P G R +++ + R
Sbjct: 824 YPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNR 883
Query: 333 IYYVDHFTRTTTWQRPTLES 352
Y + RT +R +S
Sbjct: 884 RY--QNIQRTIATERSEEDS 901
Score = 47.8 bits (112), Expect = 4e-05
Identities = 18/31 (58%), Positives = 23/31 (74%)
Query: 398 PLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428
PLPP WE R DS+GRV++V+H R T W+ P
Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
Score = 45.1 bits (105), Expect = 3e-04
Identities = 18/31 (58%), Positives = 22/31 (70%)
Query: 439 LPEGWEMRFTVDGIPYFVDHNRRTTTYIDPR 469
LP GWE++ G +FVDHN R TT+IDPR
Sbjct: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPR 1050
Score = 43.1 bits (100), Expect = 0.001
Identities = 17/31 (54%), Positives = 23/31 (74%)
Query: 399 LPPGWEKRTDSNGRVYFVNHNTRITQWEDPR 429
LP GWE +TD G+ +FV+HN+R T + DPR
Sbjct: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPR 1050
Score = 38.5 bits (88), Expect = 0.027
Identities = 18/41 (43%), Positives = 25/41 (60%), Gaps = 1/41 (2%)
Query: 283 TQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPE-PLPPG 322
T+ LP GWE + DQ G+ ++VDH + TT+ P PL G
Sbjct: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNG 1056
Score = 36.6 bits (83), Expect = 0.10
Identities = 14/32 (43%), Positives = 21/32 (65%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTL 350
LP GWE + D G+ ++VDH +R TT+ P +
Sbjct: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
Score = 36.2 bits (82), Expect = 0.13
Identities = 15/33 (45%), Positives = 20/33 (60%)
Query: 436 EKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
++PLP WE R G ++VDH RTTT+ P
Sbjct: 828 DEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 374 bits (960), Expect = e-103
Identities = 188/385 (48%), Positives = 260/385 (67%), Gaps = 6/385 (1%)
Query: 483 YVRDFKAKVQYFRFWCQQLAM---PQHIKITVTRKTLFEDSFQQIMSFSPQDLRR-RLWV 538
Y RDF+AK++ F + P +K+ + R L ED+F QIM +S +DL+R +L+V
Sbjct: 1189 YKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYV 1248
Query: 539 IFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFR 598
F GEEGLDY G +RE+FFL+S E+ NP Y LFEY+ D Y +QI+P S +H ++FR
Sbjct: 1249 TFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFR 1308
Query: 599 FIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEEC 658
F GR + +AL H +D F+ PFYK +L L DLE +D EF+ SL W+K+N+I +
Sbjct: 1309 FSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDI 1368
Query: 659 DLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFE 718
L++ F+V++E+ G+I +LKP G NI VTE+NK+EYI + +WR+ RGV +QT++
Sbjct: 1369 -LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVR 1427
Query: 719 GFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKE 777
GF E++ + + FDA+ELE+++ G EIDL+DW+ + YR Y I WFW V+
Sbjct: 1428 GFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVER 1487
Query: 778 IDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLP 837
+NE+R+RLLQFVTGT +P GFA L GSNGP++FC+EK GK LPR+HTCFNRLDLP
Sbjct: 1488 FNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLP 1547
Query: 838 PYKSYEQLKEKLLFAIEETEGFGQE 862
PY S+ L EKLL A+EET FG E
Sbjct: 1548 PYPSFSMLYEKLLTAVEETSTFGLE 1572
Score = 88.2 bits (217), Expect = 3e-17
Identities = 84/295 (28%), Positives = 124/295 (42%), Gaps = 64/295 (21%)
Query: 224 RRPASVNGSPSATS---ESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLN 280
+R S+ G+ +A + +GS+ + T EGAT G S +G +PL
Sbjct: 738 QRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGG-------SQANGHQPLR 790
Query: 281 PVTQA------------PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPE--PLPPGWER- 325
+ LPP WE R+D HGR++YVDHV + TTW RP P P +R
Sbjct: 791 SLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRS 850
Query: 326 ----RVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGN 381
+++ + R Y RT T +RP E N + + A F + I +
Sbjct: 851 NSIQQMEQLNRRY--QSIRRTMTNERP--EENTNAIDGAGEEADFHQASADFRRENILPH 906
Query: 382 QDLFATSQSKE-----------------FDPLGPLPPGWEKRTDSNGRVYFVNHNTRIT- 423
+TS+S+ F L P + T++ + + R T
Sbjct: 907 ----STSRSRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTH 962
Query: 424 ---QWEDPRSQ-GQLN-----EKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPR 469
+++ R G LN + LP GWEM+ G +FVDHN RTTT+IDPR
Sbjct: 963 HFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPR 1017
Score = 48.1 bits (113), Expect = 3e-05
Identities = 84/351 (23%), Positives = 125/351 (35%), Gaps = 47/351 (13%)
Query: 159 SASQNDDGSRSKDETRVSTNGSDD-PEDAGAGENRRVSGNNS------PSLSNGGFKPSR 211
SA Q E T+G+D DA G R VS S PS + +PS
Sbjct: 559 SADQGSAELCGSQEVDQPTSGADTGTSDASGGSRRAVSETESLDQGSEPSQVSSETEPSD 618
Query: 212 PPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTIS 271
P R + RP + A S + S T L +T ++ E A P T +
Sbjct: 619 PAR-TESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRCSSLESAR----FPETPA 673
Query: 272 GGS-----GPRPLNPVTQAPLPPGWEQRVDQHGRVYYVD---------HVEKRTTWDRPE 317
S G P + P G ++ V G + V E T D+ E
Sbjct: 674 FSSQEEEDGACAAEPTSSGPAE-GSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEE 732
Query: 318 PLPPGWERRVDNMGRIYYVDHFTR---TTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFN 374
L W+RR G + + + + T E E+ SQ G +
Sbjct: 733 -LGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRS 791
Query: 375 QRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQL 434
+ QD+ + E LPP WE R DS+GR+++V+H R T W+ P +
Sbjct: 792 LPSV--RQDVSRYQRVDE-----ALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTA---- 840
Query: 435 NEKPLPEGWEMRFTVDGIPYF---VDHNRRTTTYIDPRTGKSALDNGPQIA 482
P P+ + ++ + RRT T P +A+D + A
Sbjct: 841 --PPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEA 889
Score = 39.7 bits (91), Expect = 0.012
Identities = 16/32 (50%), Positives = 23/32 (71%)
Query: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTL 350
LP GWE + D+ G+ ++VDH +RTTT+ P L
Sbjct: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 336 bits (862), Expect = 5e-92
Identities = 168/402 (41%), Positives = 257/402 (63%), Gaps = 10/402 (2%)
Query: 469 RTGKSALDNGP---QIAYVR--DFKAKVQYFRFWCQQL---AMPQHIKITVTRKTLFEDS 520
R + L +GP + Y+R DF K +YFR ++L + + + V R +FEDS
Sbjct: 3971 RQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDS 4030
Query: 521 FQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYC 580
++++ SP++++ RL+++F GEEG D GG+ REW+ ++S E+ NPMY LF + D
Sbjct: 4031 YRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVT 4090
Query: 581 LQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESID 640
INP+S+ NP+HL YF+F+GR +A A++ + ++ F+ FYK IL K V D+ES D
Sbjct: 4091 YTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESED 4150
Query: 641 PEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMV 700
FY L+++ EN++ ++ FS + + G + DLKPNG NILVTEENK+EY+ +V
Sbjct: 4151 YHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLV 4210
Query: 701 AEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH 760
+ R++ + +Q AF EGF EI+P++ + F +ELE+L+ G+ ID++D + + Y
Sbjct: 4211 CQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK 4270
Query: 761 YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGK 820
Y S QI WFW+ ++ D R + LQFVTGT ++P+ GFA L G NG QKF I + +
Sbjct: 4271 YQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDR 4330
Query: 821 E-NWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEE-TEGFG 860
+ LP +HTCFN+LDLP Y+S+E+L+ LL AI+E +EGFG
Sbjct: 4331 STDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFG 4372
Score = 33.1 bits (74), Expect = 1.1
Identities = 24/94 (25%), Positives = 41/94 (43%), Gaps = 1/94 (1%)
Query: 180 SDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSES 239
S+ ++G+G + + ++ S + + P P+ P P T PA V + +T
Sbjct: 3470 SEAQANSGSGASSTTTATSTTSTTTTTAASTTPTPPTAPTPVTS-APALVAATAISTIVV 3528
Query: 240 DGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGG 273
S+T + P T T T + T G P +S G
Sbjct: 3529 AASTTVTTPTTATTTVSISPTTKGSKSPAKVSDG 3562
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 298 bits (764), Expect = 1e-80
Identities = 154/347 (44%), Positives = 222/347 (63%), Gaps = 4/347 (1%)
Query: 509 ITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMY 568
+ V R ++F S + + + L++ + V F GEEG+ G V REWF +LS+E++NP Y
Sbjct: 555 LLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDY 613
Query: 569 CLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILN 628
LF + D Q N SY+NPDHL YFRF G+ + +AL H + ++ F+ FYK IL
Sbjct: 614 ALFTQSA-DGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672
Query: 629 KPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILV 688
PV +D+ SIDPE+ +L W+ +N+I + LE+ FSV+ ++ G ++ LKP GG+ILV
Sbjct: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732
Query: 689 TEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEID 748
T+ NK EY+++V E R++R ++ Q AF +GF+ +P +Q FD ELE+LL GM EID
Sbjct: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792
Query: 749 LNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGS 807
++DW ++ Y Y R I WFW+ V++I E+R+ LLQFVTG+ R+P GGFA++MG
Sbjct: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852
Query: 808 NGPQKFCIEKVG-KENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAI 853
+G Q F I V N LP S TC N L LP Y S E LK++LL A+
Sbjct: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 219 bits (557), Expect = 1e-56
Identities = 136/373 (36%), Positives = 204/373 (54%), Gaps = 30/373 (8%)
Query: 507 IKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNP 566
+ + V R L DS ++ DL+++L V F GE GLD GG+ +EWF LL ++ +P
Sbjct: 417 LNMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHP 475
Query: 567 MYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRI 626
Y +F Y KD++C S D+ FR +G + +A+++ +D F YK++
Sbjct: 476 DYGMFTYH-KDSHCHWF---SSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
Query: 627 L---------NKPVGL-----KDLESIDPEFYNSL--IWVKENNIEECDLEMYFSVDKEI 670
L N PVG+ DL I PE + L + E N+EE D F V +E
Sbjct: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEE-DFYSTFQVFQEE 590
Query: 671 LGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQ 730
G IKS++LKP G I VT +N++EY+++ ++ L++ + +Q AF+ GF+ + L
Sbjct: 591 FGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALM 650
Query: 731 YFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFV 790
+E+E+L+CG ++D++ QR Y YA+T I +FW V + + +LL F
Sbjct: 651 LLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
Query: 791 TGTCRLPVGGFADLMGSNGPQKFCIEK-VGKENWLPRSHTCFNRLDLPPYKSYEQLKEKL 849
TG+ R+PVGG ADL F I K N LP +HTCFN+L LPPYKS + LK+KL
Sbjct: 711 TGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
Query: 850 LFAIEETEGFGQE 862
+ I +EGFG E
Sbjct: 764 IIGISNSEGFGLE 776
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 202 bits (515), Expect = 8e-52
Identities = 136/391 (34%), Positives = 207/391 (52%), Gaps = 25/391 (6%)
Query: 487 FKAKVQYFRFWCQQLAMPQ-HIKIT--VTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGE 543
F+ KV +F+ +Q+ M + H K+T V+R L E S + +FS D + V+F E
Sbjct: 439 FQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDE 498
Query: 544 EGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHL--KYFRFIG 601
E LD+GG REWF L+ + + LF +N L ++P P HL K + F G
Sbjct: 499 EALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPN-RPAHLRLKMYEFAG 556
Query: 602 RFIAMALFHG-------KFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENN 654
R + L+ + + F+ F +I+ + K E+ DPEFY S + NN
Sbjct: 557 RLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNN 616
Query: 655 IEECDLEMYFSVDK-EILGEI-KSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQ 712
+ ++E+ F+ +K G++ K +L G VT NK Y+ ++A++RL+ V+E+
Sbjct: 617 -DMSEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEE 675
Query: 713 TQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIY--RHYARTSKQIMW 770
+ F +G NE++P+ L FD ELE+L+CG +I ++D++ HA+ + K + W
Sbjct: 676 VEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRW 735
Query: 771 FWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTC 830
FW V + E+ RLLQF TG+ +LP GGFA L S F I + LP +HTC
Sbjct: 736 FWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHSTLPTAHTC 790
Query: 831 FNRLDLPPYKSYEQLKEKLLFAIEE-TEGFG 860
FN+L LP Y SYE++ L AI E EGFG
Sbjct: 791 FNQLCLPTYDSYEEVHRMLQLAISEGCEGFG 821
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 201 bits (511), Expect = 2e-51
Identities = 124/364 (34%), Positives = 202/364 (55%), Gaps = 21/364 (5%)
Query: 506 HIKITVTRKTLFEDSF---QQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHE 562
++++ V R + +D+ + I +P DL+++L+V F GE+G+D GGV++E+F L+ E
Sbjct: 519 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 578
Query: 563 VLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPF 622
+ NP +F Y + NP+S+ F IG + +A+++ +D F +
Sbjct: 579 IFNPDIGMFTY-DESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVV 634
Query: 623 YKRILNKPVGLKDLESIDPEFYNSL--IWVKENNIEECDLEMYFSVDK-EILGEIKSHDL 679
Y++++ K +DL P Y SL + E N+E+ D+ + F + + ++ G +DL
Sbjct: 635 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVED-DMMITFQISQTDLFGNPMMYDL 693
Query: 680 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQY-FDAKELE 738
K NG I +T EN++E++ + +++ L++ VE+Q +AF GF+ + + L+Y F +E+E
Sbjct: 694 KENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIE 753
Query: 739 VLLCGMQEIDLNDWQRHAIY-RHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLP 797
+L+CG + +D + Y Y R S I FW+ V +E++ LQF TGT R P
Sbjct: 754 LLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAP 813
Query: 798 VGGFADLMGSNGPQKFCIEKVGKE-NWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEET 856
VGG G K I K G + LP SHTCFN L LP Y S E+LKE+LL AI
Sbjct: 814 VGGL-------GKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYA 866
Query: 857 EGFG 860
+GFG
Sbjct: 867 KGFG 870
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 201 bits (511), Expect = 2e-51
Identities = 124/364 (34%), Positives = 202/364 (55%), Gaps = 21/364 (5%)
Query: 506 HIKITVTRKTLFEDSF---QQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHE 562
++++ V R + +D+ + I +P DL+++L+V F GE+G+D GGV++E+F L+ E
Sbjct: 499 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 558
Query: 563 VLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPF 622
+ NP +F Y + NP+S+ F IG + +A+++ +D F +
Sbjct: 559 IFNPDIGMFTY-DESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVV 614
Query: 623 YKRILNKPVGLKDLESIDPEFYNSL--IWVKENNIEECDLEMYFSVDK-EILGEIKSHDL 679
Y++++ K +DL P Y SL + E N+E+ D+ + F + + ++ G +DL
Sbjct: 615 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVED-DMMITFQISQTDLFGNPMMYDL 673
Query: 680 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQY-FDAKELE 738
K NG I +T EN++E++ + +++ L++ VE+Q +AF GF+ + + L+Y F +E+E
Sbjct: 674 KENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIE 733
Query: 739 VLLCGMQEIDLNDWQRHAIY-RHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLP 797
+L+CG + +D + Y Y R S I FW+ V +E++ LQF TGT R P
Sbjct: 734 LLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAP 793
Query: 798 VGGFADLMGSNGPQKFCIEKVGKE-NWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEET 856
VGG G K I K G + LP SHTCFN L LP Y S E+LKE+LL AI
Sbjct: 794 VGGL-------GKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYA 846
Query: 857 EGFG 860
+GFG
Sbjct: 847 KGFG 850
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 201 bits (511), Expect = 2e-51
Identities = 124/364 (34%), Positives = 202/364 (55%), Gaps = 21/364 (5%)
Query: 506 HIKITVTRKTLFEDSF---QQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHE 562
++++ V R + +D+ + I +P DL+++L+V F GE+G+D GGV++E+F L+ E
Sbjct: 522 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 581
Query: 563 VLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPF 622
+ NP +F Y + NP+S+ F IG + +A+++ +D F +
Sbjct: 582 IFNPDIGMFTY-DESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVV 637
Query: 623 YKRILNKPVGLKDLESIDPEFYNSL--IWVKENNIEECDLEMYFSVDK-EILGEIKSHDL 679
Y++++ K +DL P Y SL + E N+E+ D+ + F + + ++ G +DL
Sbjct: 638 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVED-DMMITFQISQTDLFGNPMMYDL 696
Query: 680 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQY-FDAKELE 738
K NG I +T EN++E++ + +++ L++ VE+Q +AF GF+ + + L+Y F +E+E
Sbjct: 697 KENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIE 756
Query: 739 VLLCGMQEIDLNDWQRHAIY-RHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLP 797
+L+CG + +D + Y Y R S I FW+ V +E++ LQF TGT R P
Sbjct: 757 LLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAP 816
Query: 798 VGGFADLMGSNGPQKFCIEKVGKE-NWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEET 856
VGG G K I K G + LP SHTCFN L LP Y S E+LKE+LL AI
Sbjct: 817 VGGL-------GKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYA 869
Query: 857 EGFG 860
+GFG
Sbjct: 870 KGFG 873
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 184 bits (466), Expect = 4e-46
Identities = 116/363 (31%), Positives = 189/363 (52%), Gaps = 15/363 (4%)
Query: 501 LAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLS 560
LA + + V R L D+ +++ S DL++ L VIF GEE +D GGV +E+F LL
Sbjct: 696 LARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLL 755
Query: 561 HEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSL 620
E+LNP+Y +F Y +D+ L + ++ +H +F IG +A+++ +D F L
Sbjct: 756 KELLNPIYGMFTYY-QDSNLLWFSDTCFV--EH-NWFHLIGITCGLAIYNSTVVDLHFPL 811
Query: 621 PFYKRILNKPVGLKDLESIDPEFYNSLIWVKE---NNIEECDLEMYFSVDKEILGEIKSH 677
YK++LN GL+DL+ + P SL + + ++EE + F++ +E G I+
Sbjct: 812 ALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEE-TFCLNFTICRESYGVIEQK 870
Query: 678 DLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKEL 737
L P G N+ V ++N++E++ + V E AF GF ++ + L+ F EL
Sbjct: 871 KLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSEL 930
Query: 738 EVLLCGMQEIDLNDWQRHAIYR-HYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRL 796
++ G + + + AIY+ Y+ T + FW+ E EK+ + L F+TG+ R+
Sbjct: 931 RAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRI 990
Query: 797 PVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEET 856
P+ G A L Q E +LP +HTC+N LDLP Y S E L +L A++
Sbjct: 991 PIYGMASL------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNY 1044
Query: 857 EGF 859
EGF
Sbjct: 1045 EGF 1047
>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 182 bits (462), Expect = 1e-45
Identities = 120/391 (30%), Positives = 192/391 (49%), Gaps = 34/391 (8%)
Query: 502 AMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPG-----EEGLDYGGVAREWF 556
A P IT+ R + ED ++Q+ S ++ + V F E G+D GV +E+
Sbjct: 676 ASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFL 735
Query: 557 FLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDT 616
+ V +P LF+ D L +P SYI+ ++L+ F F+G+ + A++ G +D
Sbjct: 736 EEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDV 794
Query: 617 GFSLPFYKRILNKP-----VGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEIL 671
F+ F ++L + +L S+D EFY +L +K + + DL + S D++++
Sbjct: 795 PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
Query: 672 GEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQY 731
G++ H+L P G I VT ENK YI ++A +R+ ++ QT A GF I+ ++++
Sbjct: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
Query: 732 FDAKELEVLLCG-MQEIDLNDWQRHAI-YRHYARTSKQIMWFWQFV-KEIDNEKRMRLLQ 788
F EL+ L+ G EIDL D ++H + Y + + + I+W W + + ++R L+
Sbjct: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLK 974
Query: 789 FVTGTCRLPVGGFA--------------------DLMGSNGPQKFCIEKVGKENWLPRSH 828
FVT R P+ GFA D +GS F I K LP S
Sbjct: 975 FVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSS 1034
Query: 829 TCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859
TCFN L LP Y L+EKL +AI GF
Sbjct: 1035 TCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
>gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 182 bits (462), Expect = 1e-45
Identities = 120/391 (30%), Positives = 192/391 (49%), Gaps = 34/391 (8%)
Query: 502 AMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPG-----EEGLDYGGVAREWF 556
A P IT+ R + ED ++Q+ S ++ + V F E G+D GV +E+
Sbjct: 676 ASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFL 735
Query: 557 FLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDT 616
+ V +P LF+ D L +P SYI+ ++L+ F F+G+ + A++ G +D
Sbjct: 736 EEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDV 794
Query: 617 GFSLPFYKRILNKP-----VGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEIL 671
F+ F ++L + +L S+D EFY +L +K + + DL + S D++++
Sbjct: 795 PFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVM 854
Query: 672 GEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQY 731
G++ H+L P G I VT ENK YI ++A +R+ ++ QT A GF I+ ++++
Sbjct: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
Query: 732 FDAKELEVLLCG-MQEIDLNDWQRHAI-YRHYARTSKQIMWFWQFV-KEIDNEKRMRLLQ 788
F EL+ L+ G EIDL D ++H + Y + + + I+W W + + ++R L+
Sbjct: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLK 974
Query: 789 FVTGTCRLPVGGFA--------------------DLMGSNGPQKFCIEKVGKENWLPRSH 828
FVT R P+ GFA D +GS F I K LP S
Sbjct: 975 FVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSS 1034
Query: 829 TCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859
TCFN L LP Y L+EKL +AI GF
Sbjct: 1035 TCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,171,642
Number of Sequences: 37866
Number of extensions: 2078146
Number of successful extensions: 19947
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 261
Number of HSP's successfully gapped in prelim test: 693
Number of HSP's that attempted gapping in prelim test: 13823
Number of HSP's gapped (non-prelim): 4986
length of query: 862
length of database: 18,247,518
effective HSP length: 111
effective length of query: 751
effective length of database: 14,044,392
effective search space: 10547338392
effective search space used: 10547338392
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.