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Search of human proteins with 27436867
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27436867 slit and trk like 4 protein [Homo sapiens]
(837 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27436867 slit and trk like 4 protein [Homo sapiens] 1691 0.0
gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens] 680 0.0
gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens] 656 0.0
gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens] 656 0.0
gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens] 656 0.0
gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens] 656 0.0
gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens] 656 0.0
gi|221136965 SLIT and NTRK-like family, member 2 [Homo sapiens] 656 0.0
gi|221136961 SLIT and NTRK-like family, member 2 [Homo sapiens] 656 0.0
gi|221136957 SLIT and NTRK-like family, member 2 [Homo sapiens] 656 0.0
gi|33504581 SLIT and NTRK-like family, member 2 [Homo sapiens] 656 0.0
gi|40217825 slit and trk like 6 [Homo sapiens] 619 e-177
gi|40217820 slit and trk like 3 protein [Homo sapiens] 587 e-167
gi|40217817 slit and trk like 1 protein [Homo sapiens] 538 e-153
gi|11321571 slit homolog 3 [Homo sapiens] 142 1e-33
gi|225579152 insulin-like growth factor binding protein, acid la... 123 8e-28
gi|4826772 insulin-like growth factor binding protein, acid labi... 123 8e-28
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 122 2e-27
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 122 2e-27
gi|188528675 slit homolog 1 [Homo sapiens] 118 2e-26
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom... 103 9e-22
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ... 102 2e-21
gi|198041768 synleurin [Homo sapiens] 98 3e-20
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho... 98 4e-20
gi|13194201 reticulon 4 receptor precursor [Homo sapiens] 97 6e-20
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 96 2e-19
gi|4759146 slit homolog 2 [Homo sapiens] 94 7e-19
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 92 2e-18
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 92 3e-18
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec... 92 3e-18
>gi|27436867 slit and trk like 4 protein [Homo sapiens]
Length = 837
Score = 1691 bits (4378), Expect = 0.0
Identities = 837/837 (100%), Positives = 837/837 (100%)
Query: 1 MFLWLFLILSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSN 60
MFLWLFLILSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSN
Sbjct: 1 MFLWLFLILSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSN 60
Query: 61 FYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELK 120
FYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELK
Sbjct: 61 FYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELK 120
Query: 121 ILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASL 180
ILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASL
Sbjct: 121 ILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASL 180
Query: 181 THLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEA 240
THLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEA
Sbjct: 181 THLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEA 240
Query: 241 ICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLV 300
ICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLV
Sbjct: 241 ICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLV 300
Query: 301 TKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVN 360
TKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVN
Sbjct: 301 TKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVN 360
Query: 361 CQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDV 420
CQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDV
Sbjct: 361 CQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDV 420
Query: 421 FHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYL 480
FHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYL
Sbjct: 421 FHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYL 480
Query: 481 NNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLV 540
NNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLV
Sbjct: 481 NNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLV 540
Query: 541 ALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITF 600
ALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITF
Sbjct: 541 ALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITF 600
Query: 601 TTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPD 660
TTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPD
Sbjct: 601 TTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPD 660
Query: 661 CGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVV 720
CGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVV
Sbjct: 661 CGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVV 720
Query: 721 MRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIR 780
MRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIR
Sbjct: 721 MRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIR 780
Query: 781 YPEKQPDKKSKKSLIGGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI 837
YPEKQPDKKSKKSLIGGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI
Sbjct: 781 YPEKQPDKKSKKSLIGGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI 837
>gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens]
Length = 958
Score = 680 bits (1755), Expect = 0.0
Identities = 397/941 (42%), Positives = 557/941 (59%), Gaps = 110/941 (11%)
Query: 1 MFLWLFLILSALISSTNADSDISVEIC-NVCSCVSVENVLYVNCEKVSVYRPNQLKPPWS 59
M L +++L+ S D EIC N C C + +L V+CE + +++ PP
Sbjct: 22 MLQTLAFAVTSLVLSCAETIDYYGEICDNACPCEEKDGILTVSCENRGIISLSEISPPRF 81
Query: 60 NFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 119
YHL N LN LYPN F+N++ A LHLG+N +Q+IE GAF GL L++LHLNNN+L
Sbjct: 82 PIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKL 141
Query: 120 KILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFAS 179
++LR DTFLG+ENLEYLQ DYN I IE AF KLH L+VLILNDNL+S LP+N+FRF
Sbjct: 142 ELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVP 201
Query: 180 LTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGE 239
LTHLD+RGNR++ LPY+G+L+H+ +VVELQLE+NPWNCSC+L+ LK WL+++ Y+ +G+
Sbjct: 202 LTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLKDWLDSISYSALVGD 261
Query: 240 AICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRL 299
+CETP L+GR L E +KQELCP SD+++R P TT HTT S++ +
Sbjct: 262 VVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQTPLS-----TTGYLHTTPASVNSV 316
Query: 300 VT----------KPPK-TTNPSKI----SGIVAGKALSNRNLSQIVSYQTRVPPLTPCPA 344
T KPPK T P+K + K L N ++YQT+ P CP
Sbjct: 317 ATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGPSIAYQTKSPVPLECPT 376
Query: 345 PCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLD 404
C C SDLGL+VNCQE+ I+S++EL PKP N KK+++ N I V +DF + GLD
Sbjct: 377 ACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGLD 436
Query: 405 LLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEI 464
LLHLG+N+I++I+ F +LTNLRRLYLNGN+IERL PE+F GL +LQYL+L+YNLI+EI
Sbjct: 437 LLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREI 496
Query: 465 SAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLT 524
+GTFD +PNLQLL+LNNNLL+++P +FSG L RLNLR+N F LPVSGVLDQL+SL
Sbjct: 497 QSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLI 556
Query: 525 QIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPK-- 582
QIDL NPWDCTCD+V +KLWVE+L G++V E+ C+ P +FA +++S+K+E+LCP
Sbjct: 557 QIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSIKSELLCPDYS 616
Query: 583 --LLNKPS-------APFTSPAPAITFTTPLGPIRSPPGG---PVPLSILILSILVVLIL 630
+++ P+ A ++ PA+ + P GG VPLS+LILS+L+V I+
Sbjct: 617 DVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAGGGASSVPLSVLILSLLLVFIM 676
Query: 631 TVFVAFCLLVFVLRRNKKPTVKHEGLGNPDCGSMQLQL-----------RKHDHKTNKKD 679
+VFVA L V V++R KK H N D S +Q H H ++
Sbjct: 677 SVFVAAGLFVLVMKRRKKNQSDHTSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGP 736
Query: 680 GL---STEA-----FIPQTIEQMSKSHTCGLKESETGFMFSD------------------ 713
L T A +IP + M K+ +E + + D
Sbjct: 737 ALPKVKTPAGHVYEYIPHPLGHMCKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQ 796
Query: 714 ---PPGQ--------KVVMRNVADKEKDLLHV-DTRKRLSTIDELDELF-PSRDSNVFIQ 760
PP Q ++ ++ ++ ++ H+ +STI+ ++L P +D++ F +
Sbjct: 797 QPPPPPQQPQQQPPPQLQLQPGEEERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYR 856
Query: 761 NFLESKK------------EYNSIGVS--------GFEIRYPEK-----QPDKKSKKSLI 795
LE K EY S +++R P + D + ++ ++
Sbjct: 857 GILEPDKHCSTTPAGNSLPEYPKFPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVL 916
Query: 796 GGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNK 836
S + VE ++EY ELKAKL PDYL+VLE+QT ++
Sbjct: 917 YSPPSAVFVEPNRNEYLELKAKLNVEPDYLEVLEKQTTFSQ 957
>gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 656 bits (1692), Expect = 0.0
Identities = 373/868 (42%), Positives = 515/868 (59%), Gaps = 60/868 (6%)
Query: 3 LWLFLILSALISSTNADSDISVEICNV-CSCVSVENVLYVNCEKVSVYRPNQLKPPWSNF 61
+W +L+ + +IC + C C ENVL +NCE + L+PP
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 62 YHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKI 121
Y L N L LYPN F+N+S+AV+LHLGNN LQ I GAF GL LK+LHLNNN+L+I
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 122 LRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLT 181
LR DTFLG+E+LEYLQADYN I IE GAF+KL+KLKVLILNDNL+ LP N+FRF LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 182 HLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAI 241
HLD+RGNR++ +P+ GVLEHIG ++E+QLE+NPWNC+CDLLPLKAWL+ + +++GE +
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTI--TVFVGEIV 242
Query: 242 CETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLV- 300
CETP L+G+ + + +Q+LCP + SD R G T + RL
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQR---------------GSHADTHVQRLSP 287
Query: 301 --------TKPPKTTNPSKISGIVAGKALSNRN---LSQIVSYQTRVPPLTPCPAPCFCK 349
T+ PK + P K+ + +++ I+ YQT+ P CP+ C C
Sbjct: 288 TMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCT 347
Query: 350 THPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLG 409
+ SD GL+VNCQE+ ++S+L PKP + KKL++ GN ++ V +D ++ LDLLHLG
Sbjct: 348 SQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLG 407
Query: 410 SNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTF 469
+N+I VI+ F NLT+LRRLYLNGN +E LYP +F GL +LQYLYLEYN+IKEI TF
Sbjct: 408 NNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTF 467
Query: 470 DSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLE 529
D++ NLQLL+LNNNLL+SLP IF G L RLNLRNN F +LPV GVLDQL + QIDL+
Sbjct: 468 DALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQ 527
Query: 530 GNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSA 589
NPWDCTCD++ LK W E + +++ E+ CE+P + A LK L E +C P +
Sbjct: 528 ENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAIC------PDS 581
Query: 590 PFTSPAPAITFT----TPLGPIRSPPGGP-----VPLSILILSILVVLILTVFVAFCLLV 640
P S ++ TP SP P VPLS+LIL +LVV IL+V L V
Sbjct: 582 PNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFV 641
Query: 641 FVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTC 700
FVL+R K N D S QLQ ++ +T+ K +IP + QM ++
Sbjct: 642 FVLKRRKGVPSVPRNTNNLDVSSFQLQYGSYNTETHDKTDGHVYNYIPPPVGQMCQNPIY 701
Query: 701 GLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQ 760
KE + + + Q+ N+ +K+++ +S + L++ R+ + Q
Sbjct: 702 MQKEGDPVAYYRNL--QEFSYSNLEEKKEE--PATPAYTISATELLEKQATPREPELLYQ 757
Query: 761 NFLESKKEYNSIGVSGFEI-RYPEKQ--PDKKSK--------KSLIGGNHSKIVVEQRKS 809
N E KE S G+ + P++Q P +S+ K+++ G K V Q K
Sbjct: 758 NIAERVKELPSAGLVHYNFCTLPKRQFAPSYESRRQNQDRINKTVLYGTPRKCFVGQSKP 817
Query: 810 EYFELKAKLQSSPDYLQVLEEQTALNKI 837
+ L+AK QS PDYL+VLE+QTA++++
Sbjct: 818 NHPLLQAKPQSEPDYLEVLEKQTAISQL 845
>gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 656 bits (1692), Expect = 0.0
Identities = 373/868 (42%), Positives = 515/868 (59%), Gaps = 60/868 (6%)
Query: 3 LWLFLILSALISSTNADSDISVEICNV-CSCVSVENVLYVNCEKVSVYRPNQLKPPWSNF 61
+W +L+ + +IC + C C ENVL +NCE + L+PP
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 62 YHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKI 121
Y L N L LYPN F+N+S+AV+LHLGNN LQ I GAF GL LK+LHLNNN+L+I
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 122 LRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLT 181
LR DTFLG+E+LEYLQADYN I IE GAF+KL+KLKVLILNDNL+ LP N+FRF LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 182 HLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAI 241
HLD+RGNR++ +P+ GVLEHIG ++E+QLE+NPWNC+CDLLPLKAWL+ + +++GE +
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTI--TVFVGEIV 242
Query: 242 CETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLV- 300
CETP L+G+ + + +Q+LCP + SD R G T + RL
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQR---------------GSHADTHVQRLSP 287
Query: 301 --------TKPPKTTNPSKISGIVAGKALSNRN---LSQIVSYQTRVPPLTPCPAPCFCK 349
T+ PK + P K+ + +++ I+ YQT+ P CP+ C C
Sbjct: 288 TMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCT 347
Query: 350 THPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLG 409
+ SD GL+VNCQE+ ++S+L PKP + KKL++ GN ++ V +D ++ LDLLHLG
Sbjct: 348 SQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLG 407
Query: 410 SNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTF 469
+N+I VI+ F NLT+LRRLYLNGN +E LYP +F GL +LQYLYLEYN+IKEI TF
Sbjct: 408 NNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTF 467
Query: 470 DSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLE 529
D++ NLQLL+LNNNLL+SLP IF G L RLNLRNN F +LPV GVLDQL + QIDL+
Sbjct: 468 DALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQ 527
Query: 530 GNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSA 589
NPWDCTCD++ LK W E + +++ E+ CE+P + A LK L E +C P +
Sbjct: 528 ENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAIC------PDS 581
Query: 590 PFTSPAPAITFT----TPLGPIRSPPGGP-----VPLSILILSILVVLILTVFVAFCLLV 640
P S ++ TP SP P VPLS+LIL +LVV IL+V L V
Sbjct: 582 PNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFV 641
Query: 641 FVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTC 700
FVL+R K N D S QLQ ++ +T+ K +IP + QM ++
Sbjct: 642 FVLKRRKGVPSVPRNTNNLDVSSFQLQYGSYNTETHDKTDGHVYNYIPPPVGQMCQNPIY 701
Query: 701 GLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQ 760
KE + + + Q+ N+ +K+++ +S + L++ R+ + Q
Sbjct: 702 MQKEGDPVAYYRNL--QEFSYSNLEEKKEE--PATPAYTISATELLEKQATPREPELLYQ 757
Query: 761 NFLESKKEYNSIGVSGFEI-RYPEKQ--PDKKSK--------KSLIGGNHSKIVVEQRKS 809
N E KE S G+ + P++Q P +S+ K+++ G K V Q K
Sbjct: 758 NIAERVKELPSAGLVHYNFCTLPKRQFAPSYESRRQNQDRINKTVLYGTPRKCFVGQSKP 817
Query: 810 EYFELKAKLQSSPDYLQVLEEQTALNKI 837
+ L+AK QS PDYL+VLE+QTA++++
Sbjct: 818 NHPLLQAKPQSEPDYLEVLEKQTAISQL 845
>gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 656 bits (1692), Expect = 0.0
Identities = 373/868 (42%), Positives = 515/868 (59%), Gaps = 60/868 (6%)
Query: 3 LWLFLILSALISSTNADSDISVEICNV-CSCVSVENVLYVNCEKVSVYRPNQLKPPWSNF 61
+W +L+ + +IC + C C ENVL +NCE + L+PP
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 62 YHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKI 121
Y L N L LYPN F+N+S+AV+LHLGNN LQ I GAF GL LK+LHLNNN+L+I
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 122 LRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLT 181
LR DTFLG+E+LEYLQADYN I IE GAF+KL+KLKVLILNDNL+ LP N+FRF LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 182 HLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAI 241
HLD+RGNR++ +P+ GVLEHIG ++E+QLE+NPWNC+CDLLPLKAWL+ + +++GE +
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTI--TVFVGEIV 242
Query: 242 CETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLV- 300
CETP L+G+ + + +Q+LCP + SD R G T + RL
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQR---------------GSHADTHVQRLSP 287
Query: 301 --------TKPPKTTNPSKISGIVAGKALSNRN---LSQIVSYQTRVPPLTPCPAPCFCK 349
T+ PK + P K+ + +++ I+ YQT+ P CP+ C C
Sbjct: 288 TMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCT 347
Query: 350 THPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLG 409
+ SD GL+VNCQE+ ++S+L PKP + KKL++ GN ++ V +D ++ LDLLHLG
Sbjct: 348 SQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLG 407
Query: 410 SNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTF 469
+N+I VI+ F NLT+LRRLYLNGN +E LYP +F GL +LQYLYLEYN+IKEI TF
Sbjct: 408 NNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTF 467
Query: 470 DSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLE 529
D++ NLQLL+LNNNLL+SLP IF G L RLNLRNN F +LPV GVLDQL + QIDL+
Sbjct: 468 DALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQ 527
Query: 530 GNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSA 589
NPWDCTCD++ LK W E + +++ E+ CE+P + A LK L E +C P +
Sbjct: 528 ENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAIC------PDS 581
Query: 590 PFTSPAPAITFT----TPLGPIRSPPGGP-----VPLSILILSILVVLILTVFVAFCLLV 640
P S ++ TP SP P VPLS+LIL +LVV IL+V L V
Sbjct: 582 PNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFV 641
Query: 641 FVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTC 700
FVL+R K N D S QLQ ++ +T+ K +IP + QM ++
Sbjct: 642 FVLKRRKGVPSVPRNTNNLDVSSFQLQYGSYNTETHDKTDGHVYNYIPPPVGQMCQNPIY 701
Query: 701 GLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQ 760
KE + + + Q+ N+ +K+++ +S + L++ R+ + Q
Sbjct: 702 MQKEGDPVAYYRNL--QEFSYSNLEEKKEE--PATPAYTISATELLEKQATPREPELLYQ 757
Query: 761 NFLESKKEYNSIGVSGFEI-RYPEKQ--PDKKSK--------KSLIGGNHSKIVVEQRKS 809
N E KE S G+ + P++Q P +S+ K+++ G K V Q K
Sbjct: 758 NIAERVKELPSAGLVHYNFCTLPKRQFAPSYESRRQNQDRINKTVLYGTPRKCFVGQSKP 817
Query: 810 EYFELKAKLQSSPDYLQVLEEQTALNKI 837
+ L+AK QS PDYL+VLE+QTA++++
Sbjct: 818 NHPLLQAKPQSEPDYLEVLEKQTAISQL 845
>gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 656 bits (1692), Expect = 0.0
Identities = 373/868 (42%), Positives = 515/868 (59%), Gaps = 60/868 (6%)
Query: 3 LWLFLILSALISSTNADSDISVEICNV-CSCVSVENVLYVNCEKVSVYRPNQLKPPWSNF 61
+W +L+ + +IC + C C ENVL +NCE + L+PP
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 62 YHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKI 121
Y L N L LYPN F+N+S+AV+LHLGNN LQ I GAF GL LK+LHLNNN+L+I
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 122 LRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLT 181
LR DTFLG+E+LEYLQADYN I IE GAF+KL+KLKVLILNDNL+ LP N+FRF LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 182 HLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAI 241
HLD+RGNR++ +P+ GVLEHIG ++E+QLE+NPWNC+CDLLPLKAWL+ + +++GE +
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTI--TVFVGEIV 242
Query: 242 CETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLV- 300
CETP L+G+ + + +Q+LCP + SD R G T + RL
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQR---------------GSHADTHVQRLSP 287
Query: 301 --------TKPPKTTNPSKISGIVAGKALSNRN---LSQIVSYQTRVPPLTPCPAPCFCK 349
T+ PK + P K+ + +++ I+ YQT+ P CP+ C C
Sbjct: 288 TMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCT 347
Query: 350 THPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLG 409
+ SD GL+VNCQE+ ++S+L PKP + KKL++ GN ++ V +D ++ LDLLHLG
Sbjct: 348 SQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLG 407
Query: 410 SNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTF 469
+N+I VI+ F NLT+LRRLYLNGN +E LYP +F GL +LQYLYLEYN+IKEI TF
Sbjct: 408 NNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTF 467
Query: 470 DSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLE 529
D++ NLQLL+LNNNLL+SLP IF G L RLNLRNN F +LPV GVLDQL + QIDL+
Sbjct: 468 DALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQ 527
Query: 530 GNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSA 589
NPWDCTCD++ LK W E + +++ E+ CE+P + A LK L E +C P +
Sbjct: 528 ENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAIC------PDS 581
Query: 590 PFTSPAPAITFT----TPLGPIRSPPGGP-----VPLSILILSILVVLILTVFVAFCLLV 640
P S ++ TP SP P VPLS+LIL +LVV IL+V L V
Sbjct: 582 PNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFV 641
Query: 641 FVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTC 700
FVL+R K N D S QLQ ++ +T+ K +IP + QM ++
Sbjct: 642 FVLKRRKGVPSVPRNTNNLDVSSFQLQYGSYNTETHDKTDGHVYNYIPPPVGQMCQNPIY 701
Query: 701 GLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQ 760
KE + + + Q+ N+ +K+++ +S + L++ R+ + Q
Sbjct: 702 MQKEGDPVAYYRNL--QEFSYSNLEEKKEE--PATPAYTISATELLEKQATPREPELLYQ 757
Query: 761 NFLESKKEYNSIGVSGFEI-RYPEKQ--PDKKSK--------KSLIGGNHSKIVVEQRKS 809
N E KE S G+ + P++Q P +S+ K+++ G K V Q K
Sbjct: 758 NIAERVKELPSAGLVHYNFCTLPKRQFAPSYESRRQNQDRINKTVLYGTPRKCFVGQSKP 817
Query: 810 EYFELKAKLQSSPDYLQVLEEQTALNKI 837
+ L+AK QS PDYL+VLE+QTA++++
Sbjct: 818 NHPLLQAKPQSEPDYLEVLEKQTAISQL 845
>gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 656 bits (1692), Expect = 0.0
Identities = 373/868 (42%), Positives = 515/868 (59%), Gaps = 60/868 (6%)
Query: 3 LWLFLILSALISSTNADSDISVEICNV-CSCVSVENVLYVNCEKVSVYRPNQLKPPWSNF 61
+W +L+ + +IC + C C ENVL +NCE + L+PP
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 62 YHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKI 121
Y L N L LYPN F+N+S+AV+LHLGNN LQ I GAF GL LK+LHLNNN+L+I
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 122 LRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLT 181
LR DTFLG+E+LEYLQADYN I IE GAF+KL+KLKVLILNDNL+ LP N+FRF LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 182 HLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAI 241
HLD+RGNR++ +P+ GVLEHIG ++E+QLE+NPWNC+CDLLPLKAWL+ + +++GE +
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTI--TVFVGEIV 242
Query: 242 CETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLV- 300
CETP L+G+ + + +Q+LCP + SD R G T + RL
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQR---------------GSHADTHVQRLSP 287
Query: 301 --------TKPPKTTNPSKISGIVAGKALSNRN---LSQIVSYQTRVPPLTPCPAPCFCK 349
T+ PK + P K+ + +++ I+ YQT+ P CP+ C C
Sbjct: 288 TMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCT 347
Query: 350 THPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLG 409
+ SD GL+VNCQE+ ++S+L PKP + KKL++ GN ++ V +D ++ LDLLHLG
Sbjct: 348 SQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLG 407
Query: 410 SNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTF 469
+N+I VI+ F NLT+LRRLYLNGN +E LYP +F GL +LQYLYLEYN+IKEI TF
Sbjct: 408 NNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTF 467
Query: 470 DSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLE 529
D++ NLQLL+LNNNLL+SLP IF G L RLNLRNN F +LPV GVLDQL + QIDL+
Sbjct: 468 DALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQ 527
Query: 530 GNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSA 589
NPWDCTCD++ LK W E + +++ E+ CE+P + A LK L E +C P +
Sbjct: 528 ENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAIC------PDS 581
Query: 590 PFTSPAPAITFT----TPLGPIRSPPGGP-----VPLSILILSILVVLILTVFVAFCLLV 640
P S ++ TP SP P VPLS+LIL +LVV IL+V L V
Sbjct: 582 PNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFV 641
Query: 641 FVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTC 700
FVL+R K N D S QLQ ++ +T+ K +IP + QM ++
Sbjct: 642 FVLKRRKGVPSVPRNTNNLDVSSFQLQYGSYNTETHDKTDGHVYNYIPPPVGQMCQNPIY 701
Query: 701 GLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQ 760
KE + + + Q+ N+ +K+++ +S + L++ R+ + Q
Sbjct: 702 MQKEGDPVAYYRNL--QEFSYSNLEEKKEE--PATPAYTISATELLEKQATPREPELLYQ 757
Query: 761 NFLESKKEYNSIGVSGFEI-RYPEKQ--PDKKSK--------KSLIGGNHSKIVVEQRKS 809
N E KE S G+ + P++Q P +S+ K+++ G K V Q K
Sbjct: 758 NIAERVKELPSAGLVHYNFCTLPKRQFAPSYESRRQNQDRINKTVLYGTPRKCFVGQSKP 817
Query: 810 EYFELKAKLQSSPDYLQVLEEQTALNKI 837
+ L+AK QS PDYL+VLE+QTA++++
Sbjct: 818 NHPLLQAKPQSEPDYLEVLEKQTAISQL 845
>gi|221136965 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 656 bits (1692), Expect = 0.0
Identities = 373/868 (42%), Positives = 515/868 (59%), Gaps = 60/868 (6%)
Query: 3 LWLFLILSALISSTNADSDISVEICNV-CSCVSVENVLYVNCEKVSVYRPNQLKPPWSNF 61
+W +L+ + +IC + C C ENVL +NCE + L+PP
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 62 YHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKI 121
Y L N L LYPN F+N+S+AV+LHLGNN LQ I GAF GL LK+LHLNNN+L+I
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 122 LRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLT 181
LR DTFLG+E+LEYLQADYN I IE GAF+KL+KLKVLILNDNL+ LP N+FRF LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 182 HLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAI 241
HLD+RGNR++ +P+ GVLEHIG ++E+QLE+NPWNC+CDLLPLKAWL+ + +++GE +
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTI--TVFVGEIV 242
Query: 242 CETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLV- 300
CETP L+G+ + + +Q+LCP + SD R G T + RL
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQR---------------GSHADTHVQRLSP 287
Query: 301 --------TKPPKTTNPSKISGIVAGKALSNRN---LSQIVSYQTRVPPLTPCPAPCFCK 349
T+ PK + P K+ + +++ I+ YQT+ P CP+ C C
Sbjct: 288 TMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCT 347
Query: 350 THPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLG 409
+ SD GL+VNCQE+ ++S+L PKP + KKL++ GN ++ V +D ++ LDLLHLG
Sbjct: 348 SQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLG 407
Query: 410 SNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTF 469
+N+I VI+ F NLT+LRRLYLNGN +E LYP +F GL +LQYLYLEYN+IKEI TF
Sbjct: 408 NNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTF 467
Query: 470 DSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLE 529
D++ NLQLL+LNNNLL+SLP IF G L RLNLRNN F +LPV GVLDQL + QIDL+
Sbjct: 468 DALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQ 527
Query: 530 GNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSA 589
NPWDCTCD++ LK W E + +++ E+ CE+P + A LK L E +C P +
Sbjct: 528 ENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAIC------PDS 581
Query: 590 PFTSPAPAITFT----TPLGPIRSPPGGP-----VPLSILILSILVVLILTVFVAFCLLV 640
P S ++ TP SP P VPLS+LIL +LVV IL+V L V
Sbjct: 582 PNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFV 641
Query: 641 FVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTC 700
FVL+R K N D S QLQ ++ +T+ K +IP + QM ++
Sbjct: 642 FVLKRRKGVPSVPRNTNNLDVSSFQLQYGSYNTETHDKTDGHVYNYIPPPVGQMCQNPIY 701
Query: 701 GLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQ 760
KE + + + Q+ N+ +K+++ +S + L++ R+ + Q
Sbjct: 702 MQKEGDPVAYYRNL--QEFSYSNLEEKKEE--PATPAYTISATELLEKQATPREPELLYQ 757
Query: 761 NFLESKKEYNSIGVSGFEI-RYPEKQ--PDKKSK--------KSLIGGNHSKIVVEQRKS 809
N E KE S G+ + P++Q P +S+ K+++ G K V Q K
Sbjct: 758 NIAERVKELPSAGLVHYNFCTLPKRQFAPSYESRRQNQDRINKTVLYGTPRKCFVGQSKP 817
Query: 810 EYFELKAKLQSSPDYLQVLEEQTALNKI 837
+ L+AK QS PDYL+VLE+QTA++++
Sbjct: 818 NHPLLQAKPQSEPDYLEVLEKQTAISQL 845
>gi|221136961 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 656 bits (1692), Expect = 0.0
Identities = 373/868 (42%), Positives = 515/868 (59%), Gaps = 60/868 (6%)
Query: 3 LWLFLILSALISSTNADSDISVEICNV-CSCVSVENVLYVNCEKVSVYRPNQLKPPWSNF 61
+W +L+ + +IC + C C ENVL +NCE + L+PP
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 62 YHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKI 121
Y L N L LYPN F+N+S+AV+LHLGNN LQ I GAF GL LK+LHLNNN+L+I
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 122 LRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLT 181
LR DTFLG+E+LEYLQADYN I IE GAF+KL+KLKVLILNDNL+ LP N+FRF LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 182 HLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAI 241
HLD+RGNR++ +P+ GVLEHIG ++E+QLE+NPWNC+CDLLPLKAWL+ + +++GE +
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTI--TVFVGEIV 242
Query: 242 CETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLV- 300
CETP L+G+ + + +Q+LCP + SD R G T + RL
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQR---------------GSHADTHVQRLSP 287
Query: 301 --------TKPPKTTNPSKISGIVAGKALSNRN---LSQIVSYQTRVPPLTPCPAPCFCK 349
T+ PK + P K+ + +++ I+ YQT+ P CP+ C C
Sbjct: 288 TMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCT 347
Query: 350 THPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLG 409
+ SD GL+VNCQE+ ++S+L PKP + KKL++ GN ++ V +D ++ LDLLHLG
Sbjct: 348 SQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLG 407
Query: 410 SNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTF 469
+N+I VI+ F NLT+LRRLYLNGN +E LYP +F GL +LQYLYLEYN+IKEI TF
Sbjct: 408 NNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTF 467
Query: 470 DSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLE 529
D++ NLQLL+LNNNLL+SLP IF G L RLNLRNN F +LPV GVLDQL + QIDL+
Sbjct: 468 DALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQ 527
Query: 530 GNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSA 589
NPWDCTCD++ LK W E + +++ E+ CE+P + A LK L E +C P +
Sbjct: 528 ENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAIC------PDS 581
Query: 590 PFTSPAPAITFT----TPLGPIRSPPGGP-----VPLSILILSILVVLILTVFVAFCLLV 640
P S ++ TP SP P VPLS+LIL +LVV IL+V L V
Sbjct: 582 PNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFV 641
Query: 641 FVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTC 700
FVL+R K N D S QLQ ++ +T+ K +IP + QM ++
Sbjct: 642 FVLKRRKGVPSVPRNTNNLDVSSFQLQYGSYNTETHDKTDGHVYNYIPPPVGQMCQNPIY 701
Query: 701 GLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQ 760
KE + + + Q+ N+ +K+++ +S + L++ R+ + Q
Sbjct: 702 MQKEGDPVAYYRNL--QEFSYSNLEEKKEE--PATPAYTISATELLEKQATPREPELLYQ 757
Query: 761 NFLESKKEYNSIGVSGFEI-RYPEKQ--PDKKSK--------KSLIGGNHSKIVVEQRKS 809
N E KE S G+ + P++Q P +S+ K+++ G K V Q K
Sbjct: 758 NIAERVKELPSAGLVHYNFCTLPKRQFAPSYESRRQNQDRINKTVLYGTPRKCFVGQSKP 817
Query: 810 EYFELKAKLQSSPDYLQVLEEQTALNKI 837
+ L+AK QS PDYL+VLE+QTA++++
Sbjct: 818 NHPLLQAKPQSEPDYLEVLEKQTAISQL 845
>gi|221136957 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 656 bits (1692), Expect = 0.0
Identities = 373/868 (42%), Positives = 515/868 (59%), Gaps = 60/868 (6%)
Query: 3 LWLFLILSALISSTNADSDISVEICNV-CSCVSVENVLYVNCEKVSVYRPNQLKPPWSNF 61
+W +L+ + +IC + C C ENVL +NCE + L+PP
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 62 YHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKI 121
Y L N L LYPN F+N+S+AV+LHLGNN LQ I GAF GL LK+LHLNNN+L+I
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 122 LRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLT 181
LR DTFLG+E+LEYLQADYN I IE GAF+KL+KLKVLILNDNL+ LP N+FRF LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 182 HLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAI 241
HLD+RGNR++ +P+ GVLEHIG ++E+QLE+NPWNC+CDLLPLKAWL+ + +++GE +
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTI--TVFVGEIV 242
Query: 242 CETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLV- 300
CETP L+G+ + + +Q+LCP + SD R G T + RL
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQR---------------GSHADTHVQRLSP 287
Query: 301 --------TKPPKTTNPSKISGIVAGKALSNRN---LSQIVSYQTRVPPLTPCPAPCFCK 349
T+ PK + P K+ + +++ I+ YQT+ P CP+ C C
Sbjct: 288 TMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCT 347
Query: 350 THPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLG 409
+ SD GL+VNCQE+ ++S+L PKP + KKL++ GN ++ V +D ++ LDLLHLG
Sbjct: 348 SQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLG 407
Query: 410 SNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTF 469
+N+I VI+ F NLT+LRRLYLNGN +E LYP +F GL +LQYLYLEYN+IKEI TF
Sbjct: 408 NNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTF 467
Query: 470 DSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLE 529
D++ NLQLL+LNNNLL+SLP IF G L RLNLRNN F +LPV GVLDQL + QIDL+
Sbjct: 468 DALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQ 527
Query: 530 GNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSA 589
NPWDCTCD++ LK W E + +++ E+ CE+P + A LK L E +C P +
Sbjct: 528 ENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAIC------PDS 581
Query: 590 PFTSPAPAITFT----TPLGPIRSPPGGP-----VPLSILILSILVVLILTVFVAFCLLV 640
P S ++ TP SP P VPLS+LIL +LVV IL+V L V
Sbjct: 582 PNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFV 641
Query: 641 FVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTC 700
FVL+R K N D S QLQ ++ +T+ K +IP + QM ++
Sbjct: 642 FVLKRRKGVPSVPRNTNNLDVSSFQLQYGSYNTETHDKTDGHVYNYIPPPVGQMCQNPIY 701
Query: 701 GLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQ 760
KE + + + Q+ N+ +K+++ +S + L++ R+ + Q
Sbjct: 702 MQKEGDPVAYYRNL--QEFSYSNLEEKKEE--PATPAYTISATELLEKQATPREPELLYQ 757
Query: 761 NFLESKKEYNSIGVSGFEI-RYPEKQ--PDKKSK--------KSLIGGNHSKIVVEQRKS 809
N E KE S G+ + P++Q P +S+ K+++ G K V Q K
Sbjct: 758 NIAERVKELPSAGLVHYNFCTLPKRQFAPSYESRRQNQDRINKTVLYGTPRKCFVGQSKP 817
Query: 810 EYFELKAKLQSSPDYLQVLEEQTALNKI 837
+ L+AK QS PDYL+VLE+QTA++++
Sbjct: 818 NHPLLQAKPQSEPDYLEVLEKQTAISQL 845
>gi|33504581 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 656 bits (1692), Expect = 0.0
Identities = 373/868 (42%), Positives = 515/868 (59%), Gaps = 60/868 (6%)
Query: 3 LWLFLILSALISSTNADSDISVEICNV-CSCVSVENVLYVNCEKVSVYRPNQLKPPWSNF 61
+W +L+ + +IC + C C ENVL +NCE + L+PP
Sbjct: 5 VWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRI 64
Query: 62 YHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKI 121
Y L N L LYPN F+N+S+AV+LHLGNN LQ I GAF GL LK+LHLNNN+L+I
Sbjct: 65 YQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEI 124
Query: 122 LRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLT 181
LR DTFLG+E+LEYLQADYN I IE GAF+KL+KLKVLILNDNL+ LP N+FRF LT
Sbjct: 125 LREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLT 184
Query: 182 HLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAI 241
HLD+RGNR++ +P+ GVLEHIG ++E+QLE+NPWNC+CDLLPLKAWL+ + +++GE +
Sbjct: 185 HLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTI--TVFVGEIV 242
Query: 242 CETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLV- 300
CETP L+G+ + + +Q+LCP + SD R G T + RL
Sbjct: 243 CETPFRLHGKDVTQLTRQDLCPRKSASDSSQR---------------GSHADTHVQRLSP 287
Query: 301 --------TKPPKTTNPSKISGIVAGKALSNRN---LSQIVSYQTRVPPLTPCPAPCFCK 349
T+ PK + P K+ + +++ I+ YQT+ P CP+ C C
Sbjct: 288 TMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCT 347
Query: 350 THPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLG 409
+ SD GL+VNCQE+ ++S+L PKP + KKL++ GN ++ V +D ++ LDLLHLG
Sbjct: 348 SQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLG 407
Query: 410 SNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTF 469
+N+I VI+ F NLT+LRRLYLNGN +E LYP +F GL +LQYLYLEYN+IKEI TF
Sbjct: 408 NNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTF 467
Query: 470 DSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLE 529
D++ NLQLL+LNNNLL+SLP IF G L RLNLRNN F +LPV GVLDQL + QIDL+
Sbjct: 468 DALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQ 527
Query: 530 GNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSA 589
NPWDCTCD++ LK W E + +++ E+ CE+P + A LK L E +C P +
Sbjct: 528 ENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAIC------PDS 581
Query: 590 PFTSPAPAITFT----TPLGPIRSPPGGP-----VPLSILILSILVVLILTVFVAFCLLV 640
P S ++ TP SP P VPLS+LIL +LVV IL+V L V
Sbjct: 582 PNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFV 641
Query: 641 FVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTC 700
FVL+R K N D S QLQ ++ +T+ K +IP + QM ++
Sbjct: 642 FVLKRRKGVPSVPRNTNNLDVSSFQLQYGSYNTETHDKTDGHVYNYIPPPVGQMCQNPIY 701
Query: 701 GLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQ 760
KE + + + Q+ N+ +K+++ +S + L++ R+ + Q
Sbjct: 702 MQKEGDPVAYYRNL--QEFSYSNLEEKKEE--PATPAYTISATELLEKQATPREPELLYQ 757
Query: 761 NFLESKKEYNSIGVSGFEI-RYPEKQ--PDKKSK--------KSLIGGNHSKIVVEQRKS 809
N E KE S G+ + P++Q P +S+ K+++ G K V Q K
Sbjct: 758 NIAERVKELPSAGLVHYNFCTLPKRQFAPSYESRRQNQDRINKTVLYGTPRKCFVGQSKP 817
Query: 810 EYFELKAKLQSSPDYLQVLEEQTALNKI 837
+ L+AK QS PDYL+VLE+QTA++++
Sbjct: 818 NHPLLQAKPQSEPDYLEVLEKQTAISQL 845
>gi|40217825 slit and trk like 6 [Homo sapiens]
Length = 841
Score = 619 bits (1596), Expect = e-177
Identities = 352/864 (40%), Positives = 501/864 (57%), Gaps = 55/864 (6%)
Query: 1 MFLWLFLILSALISSTNADSDISV-----EICNVCSCVSVENVLYVNCEKVSVYRPNQLK 55
M LW+ L S+L++ + S V ++C+C + + +NCE + +++
Sbjct: 1 MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEIS 60
Query: 56 PPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLN 115
P S + L+ NN L +L+ N F ++A+S+HLG N + +IE GAF GL LKQLH+N
Sbjct: 61 VPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHIN 120
Query: 116 NNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIF 175
+N L+IL+ DTF G+ENLE+LQAD N I IE AF+KL++LKVLILNDN I LP NIF
Sbjct: 121 HNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIF 180
Query: 176 RFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNI 235
RF LTHLD+RGN++Q LPY+G LEHIGR+++LQLEDN W C+CDLL LK WLENMP
Sbjct: 181 RFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQS 240
Query: 236 YIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTS 295
IG+ +C +P G +L K+ +CP PP E+ + + H TS
Sbjct: 241 IIGDVVCNSPPFFKGSILSRLKKESICPT-----------PPVYEEHEDPSGSLHLAATS 289
Query: 296 LHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTP---CPAPCFCKTHP 352
KTT+ K+ G ++ Y T+ P CP PC CK
Sbjct: 290 SINDSRMSTKTTSILKLPTKAPG----------LIPYITKPSTQLPGPYCPIPCNCKVL- 338
Query: 353 SDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQ 412
S GL ++CQE+NI+S+S+L P P N +KL + GN I + SD ++ L++LHLG+N+
Sbjct: 339 SPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNR 398
Query: 413 ITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSM 472
I V++ F NLT L++LYLNGN + +L +F GLHNL+YLYLEYN IKEI GTF+ M
Sbjct: 399 IEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPM 458
Query: 473 PNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNP 532
P L++LYLNNNLL+ LP +IFSG PL ++NL+ N+F +LPVS +LD L LTQIDLE NP
Sbjct: 459 PKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNP 518
Query: 533 WDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFT 592
WDC+CDLV L+ W++KLS V ++ C +P ELK+L +EILCP L+N PS P
Sbjct: 519 WDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQ 578
Query: 593 S-----PAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNK 647
+ PA T T +RS VPLS+LIL +L++ I VF A ++V VL R +
Sbjct: 579 TSYLMVTTPATTTNTADTILRSLTDA-VPLSVLILGLLIMFITIVFCAAGIVVLVLHRRR 637
Query: 648 KPTVKHEGLGNPDCGSMQLQLRKHDHK-----TNKKDGLSTEAFIPQTIEQMSKSHTCGL 702
+ K D + LQ + HK T + E + + + +S + G
Sbjct: 638 RYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGP 697
Query: 703 KESETGFMFSDPPGQ--KVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQ 760
K E ++ G K + R++ ++E + + T ++ E +D++ +
Sbjct: 698 KHLEEEEERNEKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYR 757
Query: 761 NFLESKKEYNSIGVSGF------------EIRYPEKQPDKKSKKSLIGGNHSKIVVEQRK 808
N LE ++E +G++ + E YP + K ++L+ K++VEQ K
Sbjct: 758 NILEKERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTK 817
Query: 809 SEYFELKAKLQSSPDYLQVLEEQT 832
+EYFELKA L + PDYL+VLE+QT
Sbjct: 818 NEYFELKANLHAEPDYLEVLEQQT 841
>gi|40217820 slit and trk like 3 protein [Homo sapiens]
Length = 977
Score = 587 bits (1512), Expect = e-167
Identities = 312/675 (46%), Positives = 436/675 (64%), Gaps = 34/675 (5%)
Query: 3 LWLFLILSALISSTNA-----DSDISVEIC-NVCSCVSVENVLYVNCEKVSVYRPNQLKP 56
LW+ L+ + + T DS+ E C + C C E++ +++C+ +Q+
Sbjct: 15 LWIILLSTIALGWTTPIPLIEDSEEIDEPCFDPCYCEVKESLFHIHCDSKGFTNISQITE 74
Query: 57 PWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNN 116
WS + L Q N + LY N+FL+ ++AVS++LGNN LQ+I+ GAF GL LK+L+L+
Sbjct: 75 FWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHE 134
Query: 117 NELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR 176
N+L + R DTFLG+E+LEYLQADYN+IK IE GAF L KL+VLILNDNLI LP N+F+
Sbjct: 135 NKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFK 194
Query: 177 FASLTHLDIRGNRIQKLPYIGVLEHIGR-VVELQLEDNPWNCSCDLLPLKAWLENMPYNI 235
SLTHLD+RGNR++ L Y G+L+HIGR ++ELQLE+NPWNC+C+++ LK+WLE +PY
Sbjct: 195 AVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTA 254
Query: 236 YIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPP---SQLENGYTTPNG--- 289
+G+ CETP +G+ L+E K ELCP+ + S+ + + P S EN + T
Sbjct: 255 LVGDITCETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENAWPTKPSSML 314
Query: 290 ---HTTQTSL-HRLVTKPPKTTN-------PSKISGIVAGKALSNRNLSQIVSYQTRVPP 338
H T +S+ ++ K PK T PS + G N I YQTR P
Sbjct: 315 SSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGP-----NQPPIAPYQTRPPI 369
Query: 339 LTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFT 398
CP C C H +DLGL+VNC+E+ ++SEL+P+PLNAKKL+++ N I+ + SDF
Sbjct: 370 PIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFW 429
Query: 399 DFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEY 458
+F LDLLHLG+N+I+ ++ F NL NL+ L+LNGN IE+L P +F GL +L YLY E+
Sbjct: 430 NFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEF 489
Query: 459 NLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLD 518
N+I+EI F MPNL+LL+LNNNLL++LP F+G LARLNLR N F+YLPV+GVL+
Sbjct: 490 NVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLE 549
Query: 519 QLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEI 578
L ++ QIDL NPWDCTCDLV K W+E +S VV ++ C +P + ++++++ E+
Sbjct: 550 HLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRTIELEV 609
Query: 579 LCPKLLNKPSAPFTSPAPA----ITFTTPLGPIR-SPPGGPVPLSILILSILVVLILTVF 633
LCP++L+ A + P I T P SPPGGPVPLS+LILS+LV+ VF
Sbjct: 610 LCPEMLHVAPAGESPAQPGDSHLIGAPTSASPYEFSPPGGPVPLSVLILSLLVLFFSAVF 669
Query: 634 VAFCLLVFVLRRNKK 648
VA L +VLRR +K
Sbjct: 670 VAAGLFAYVLRRRRK 684
Score = 47.8 bits (112), Expect = 4e-05
Identities = 24/55 (43%), Positives = 37/55 (67%), Gaps = 1/55 (1%)
Query: 779 IRYPEKQPDKKSKKSLIGGNHSKIVVEQ-RKSEYFELKAKLQSSPDYLQVLEEQT 832
++YP+ Q D + K++L+ Q +KS+Y EL+AKLQ+ PDYL+VLE+ T
Sbjct: 920 MQYPDLQQDARLKETLLFSAGKGFTDHQTQKSDYLELRAKLQTKPDYLEVLEKTT 974
>gi|40217817 slit and trk like 1 protein [Homo sapiens]
Length = 696
Score = 538 bits (1386), Expect = e-153
Identities = 289/672 (43%), Positives = 410/672 (61%), Gaps = 14/672 (2%)
Query: 1 MFLWLFLILSAL-ISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWS 59
M LW+ L+ ++L ++ N D+ E +CSC +E L+V+CEK + P S
Sbjct: 1 MLLWILLLETSLCFAAGNVTGDVCKE--KICSCNEIEGDLHVDCEKKGFTSLQRFTAPTS 58
Query: 60 NFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 119
FYHL N L L+PN F NF +AVSLH+ NN L I GAFLGL +K+LH+NNN++
Sbjct: 59 QFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKI 118
Query: 120 KILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFAS 179
K R TFLG+++LEYLQAD+NL++ I+ GAF L+KL+VLILNDNLIS LP N+F++
Sbjct: 119 KSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVP 178
Query: 180 LTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGE 239
+THLD+RGNR++ LPY VLE I + E+ LEDNPW+C+CDLL LK WLEN+P N IG
Sbjct: 179 ITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGR 238
Query: 240 AICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRL 299
+CE P+ L G+ L ET +Q+LCP+ D + PP+Q E P +T+
Sbjct: 239 VVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLP-APPAQEETFAPGPLPTPFKTNGQED 297
Query: 300 VTKPPKTTN-PSKISGIVAGKALSNRNLSQIVSYQTRVPPLT---PCPAPCFCKTHPSDL 355
P N +KI G + R + I + +R PL PCP C C P
Sbjct: 298 HATPGSAPNGGTKIPG---NWQIKIRPTAAIATGSSRNKPLANSLPCPGGCSCDHIPGS- 353
Query: 356 GLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITV 415
GL +NC +N+ S+++L PK N ++L + N I + S F D++ L LL LG+N I
Sbjct: 354 GLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIAT 413
Query: 416 IKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNL 475
++ + F NL +LR LY++ N ++ L E F+GL NL+YL +EYN I+ I GTF++MP L
Sbjct: 414 VENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKL 473
Query: 476 QLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDC 535
++L LNNNLL+SLPV +F+G L++L+L NN FMYLPV+GVLDQL S+ QIDL GNPW+C
Sbjct: 474 RILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWEC 533
Query: 536 TCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPA 595
+C +V K W E+L +++ +LKCETPV F + L N+ +CP+L + S TS +
Sbjct: 534 SCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYARISPTLTSHS 593
Query: 596 PAITFTTPLGPIRSP--PGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKH 653
T G + V +S+L+ +L+V + + F +LVF+LR K+ +
Sbjct: 594 KNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRD 653
Query: 654 EGLGNPDCGSMQ 665
+ S+Q
Sbjct: 654 ANSSASEINSLQ 665
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 142 bits (359), Expect = 1e-33
Identities = 131/520 (25%), Positives = 210/520 (40%), Gaps = 102/520 (19%)
Query: 60 NFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 119
N L+ N + + F + LHL +N++ IE GAF L L++L LN N+L
Sbjct: 62 NAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKL 121
Query: 120 KILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FA 178
++L F L L N I+ I R AF + +K L L++N IS + D FR
Sbjct: 122 QVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALR 181
Query: 179 SLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIG 238
L L + N I ++ + H+ ++ L+L N C C L L WL +G
Sbjct: 182 DLEILTLNNNNISRI-LVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRT---VG 237
Query: 239 E-AICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLH 297
+ +C P L G + + K+E Y P H+
Sbjct: 238 QFTLCMAPVHLRGFNVADVQKKE-----------------------YVCPAPHSE----- 269
Query: 298 RLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGL 357
P + N + IS CP+PC C +
Sbjct: 270 ------PPSCNANSIS----------------------------CPSPCTCSNN------ 289
Query: 358 SVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIK 417
V+C+ K + + +P+ + ++ + NSIK + FT ++ L + + NQI+ I
Sbjct: 290 IVDCRGKGLMEIPANLPEGI--VEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIA 347
Query: 418 GDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQL 477
D F L +L L L GN+I + +F GL +LQ L L N I + TF + NL L
Sbjct: 348 PDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNL 407
Query: 478 LYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTC 537
L L +N L+++ G+ LQS+ + L NP+ C C
Sbjct: 408 LSLYDNKLQTIS------------------------KGLFAPLQSIQTLHLAQNPFVCDC 443
Query: 538 DLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNE 577
L L +++ + I +C +P + AN + +K++
Sbjct: 444 HLKWLADYLQ--DNPIETSGARCSSPRRLANKRISQIKSK 481
Score = 106 bits (264), Expect = 1e-22
Identities = 100/399 (25%), Positives = 177/399 (44%), Gaps = 46/399 (11%)
Query: 86 VSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKY 145
V + L N ++ I GAF LK++ ++ N++ + D F G+++L L N I
Sbjct: 310 VEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITE 369
Query: 146 IERGAFNKLHKLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRIQKLPYIGVLEHIGR 204
I +G F+ L L++L+LN N I+ L N F+ +L L + N++Q + G+ +
Sbjct: 370 IAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISK-GLFAPLQS 428
Query: 205 VVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPM 264
+ L L NP+ C C L L +L++ P I A C +P L + + + ++
Sbjct: 429 IQTLHLAQNPFVCDCHLKWLADYLQDNP--IETSGARCSSPRRLANKRISQIKSKKFRCS 486
Query: 265 GTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNR 324
G+ D+ R ++ + P K + G + SN+
Sbjct: 487 GS-EDYRSRFSSECFMD------------------LVCPEK----CRCEGTIVD--CSNQ 521
Query: 325 NLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHV 384
L +I P + +DL L+ N E ++ + + K N +K+++
Sbjct: 522 KLVRI---------------PSHLPEYVTDLRLNDN--EVSVLEATGIFKKLPNLRKINL 564
Query: 385 NGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEI 444
+ N IK+V F + L L NQ+ + G VF L+ L+ L L N I + +
Sbjct: 565 SNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDT 624
Query: 445 FSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNN 483
F+GL +++ L L N I I+ G F ++ +L + L +N
Sbjct: 625 FAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSN 663
Score = 96.3 bits (238), Expect = 1e-19
Identities = 108/461 (23%), Positives = 186/461 (40%), Gaps = 80/461 (17%)
Query: 131 ENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFL-PDNIFRFASLTHLDIRGNR 189
E + ++ + N IK I GAF + KLK + ++ N IS + PD SLT L + GN+
Sbjct: 307 EGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNK 366
Query: 190 IQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLY 249
I ++ G+ + + + L L N NC L + + + N+ LY
Sbjct: 367 ITEIAK-GLFDGLVSLQLLLLNANKINC----LRVNTFQDLQNLNLL----------SLY 411
Query: 250 GRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNP 309
L+ +K P+ ++ + N L L NP
Sbjct: 412 DNKLQTISKGLFAPL-------------QSIQTLHLAQNPFVCDCHLKWLADY--LQDNP 456
Query: 310 SKISGIVAG--KALSNRNLSQIVSYQTRVPPLTP--------------CPAPCFCKTHPS 353
+ SG + L+N+ +SQI S + R CP C C+
Sbjct: 457 IETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCE---- 512
Query: 354 DLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQI 413
G V+C + + + +P+ + +L+ N S+ + F L ++L +N+I
Sbjct: 513 --GTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEA-TGIFKKLPNLRKINLSNNKI 569
Query: 414 TVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMP 473
++ F +++ L L GNQ+E ++ +F GL L+ L L NLI +S TF +
Sbjct: 570 KEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLS 629
Query: 474 NLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPW 533
+++LL L +N + ++ G L SL+ I+L NP+
Sbjct: 630 SVRLLSLYDNRITTI------------------------TPGAFTTLVSLSTINLLSNPF 665
Query: 534 DCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSL 574
+C C L L W+ K IV +C+ P I ++ +
Sbjct: 666 NCNCHLAWLGKWLRKRR--IVSGNPRCQKPFFLKEIPIQDV 704
Score = 84.3 bits (207), Expect = 4e-16
Identities = 72/277 (25%), Positives = 116/277 (41%), Gaps = 61/277 (22%)
Query: 337 PPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSD 396
PP CP C C SV+C ++++ IP+ NA++L ++ N+I + D
Sbjct: 29 PPAVACPTKCTCSA------ASVDCHGLGLRAVPRGIPR--NAERLDLDRNNITRITKMD 80
Query: 397 FTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEI------------ 444
F + L +LHL NQ++VI+ F +L L RL LN N+++ L PE+
Sbjct: 81 FAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVL-PELLFQSTPKLTRLD 139
Query: 445 -------------FSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVY 491
F G+ +++ L L+ N I I G F ++ +L++L LNNN + + V
Sbjct: 140 LSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVT 199
Query: 492 IFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSD 551
F+ P R + L N C C L L W+ +
Sbjct: 200 SFNHMPKIR------------------------TLRLHSNHLYCDCHLAWLSDWLRQRR- 234
Query: 552 GIVVKELKCETPVQFANIELKSL-KNEILCPKLLNKP 587
V + C PV + + K E +CP ++P
Sbjct: 235 -TVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEP 270
Score = 68.9 bits (167), Expect = 2e-11
Identities = 94/433 (21%), Positives = 157/433 (36%), Gaps = 85/433 (19%)
Query: 36 ENVLYVNCEKVSVYR-PNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNK 94
E ++ + E+ S+ P + ++ N ++ + P+ F SL L NK
Sbjct: 307 EGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNK 366
Query: 95 LQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKL 154
+ I G F GL +L+ L LN N++ LR +TF ++NL L N ++ I +G F L
Sbjct: 367 ITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPL 426
Query: 155 HKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNP 214
++ L L NP
Sbjct: 427 QSIQTL------------------------------------------------HLAQNP 438
Query: 215 WNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRI 274
+ C C L L +L++ P I A C +P L + + + ++ G+ D R
Sbjct: 439 FVCDCHLKWLADYLQDNP--IETSGARCSSPRRLANKRISQIKSKKFRCSGSE---DYRS 493
Query: 275 LPPSQLENGYTTP-----NGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLS-- 327
S+ P G S +LV PS + V L++ +S
Sbjct: 494 RFSSECFMDLVCPEKCRCEGTIVDCSNQKLV------RIPSHLPEYVTDLRLNDNEVSVL 547
Query: 328 QIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSE-LIPKPLNAKKLHVNG 386
+ ++P L +N I+ + E + ++L + G
Sbjct: 548 EATGIFKKLPNLR-----------------KINLSNNKIKEVREGAFDGAASVQELMLTG 590
Query: 387 NSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFS 446
N ++ V F GL L L SN I + D F L+++R L L N+I + P F+
Sbjct: 591 NQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFT 650
Query: 447 GLHNLQYLYLEYN 459
L +L + L N
Sbjct: 651 TLVSLSTINLLSN 663
Score = 68.6 bits (166), Expect = 2e-11
Identities = 89/398 (22%), Positives = 152/398 (38%), Gaps = 55/398 (13%)
Query: 41 VNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPN-TFLNFSHAVSLHLGNNKLQNIE 99
V+C + R P + LN +N +++L F + ++L NNK++ +
Sbjct: 516 VDCSNQKLVRIPSHLPEYVTDLRLN--DNEVSVLEATGIFKKLPNLRKINLSNNKIKEVR 573
Query: 100 GGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKV 159
GAF G +++++L L N+L+ + F G+ L+ L NLI + F L +++
Sbjct: 574 EGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRL 633
Query: 160 LILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSC 219
L L DN I+ + F +L L + L NP+NC+C
Sbjct: 634 LSLYDNRITTITPG--AFTTLVSLS----------------------TINLLSNPFNCNC 669
Query: 220 DLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQ 279
L L WL I G C+ P LKE Q++ DF S
Sbjct: 670 HLAWLGKWLRKR--RIVSGNPRCQKPF-----FLKEIPIQDVAI----QDFTCDGNEESS 718
Query: 280 LENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPL 339
+ P T ++ R K + P + V L +L+ + + + L
Sbjct: 719 CQLSPRCPEQCTCMETVVRCSNKGLRAL-PRGMPKDVTELYLEGNHLTAVPRELSALRHL 777
Query: 340 TPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTD 399
T + + + N N+ +S LI ++ N ++ + V F
Sbjct: 778 T------LIDLSNNSISMLTNYTFSNMSHLSTLI----------LSYNRLRCIPVHAFNG 821
Query: 400 FEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQI 437
L +L L N I+ + F++LT+L L L N +
Sbjct: 822 LRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 859
Score = 65.1 bits (157), Expect = 3e-10
Identities = 72/269 (26%), Positives = 113/269 (42%), Gaps = 40/269 (14%)
Query: 310 SKISGIVAGKALSNRNLSQIVS-YQTRVPPLTP--------------CPAPCFCKTHPSD 354
S + G V+ + + +++S Y R+ +TP P C H +
Sbjct: 614 SNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAW 673
Query: 355 LGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFT----DFEGLDLLHLGS 410
LG + +++ I S + KP K++ I+DV + DFT + L
Sbjct: 674 LGKWL--RKRRIVSGNPRCQKPFFLKEI-----PIQDVAIQDFTCDGNEESSCQLSPRCP 726
Query: 411 NQITVIKGDVFHNLTNLR-----------RLYLNGNQIERLYPEIFSGLHNLQYLYLEYN 459
Q T ++ V + LR LYL GN + + P S L +L + L N
Sbjct: 727 EQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAV-PRELSALRHLTLIDLSNN 785
Query: 460 LIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLAR-LNLRNNKFMYLPVSGVLD 518
I ++ TF +M +L L L+ N L+ +PV+ F+G R L L N +P G +
Sbjct: 786 SISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVP-EGSFN 844
Query: 519 QLQSLTQIDLEGNPWDCTCDLVALKLWVE 547
L SL+ + L NP C C L L WV+
Sbjct: 845 DLTSLSHLALGTNPLHCDCSLRWLSEWVK 873
Score = 55.5 bits (132), Expect = 2e-07
Identities = 50/155 (32%), Positives = 68/155 (43%), Gaps = 31/155 (20%)
Query: 106 LSALKQL---HLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLIL 162
LSAL+ L L+NN + +L TF + +L L YN ++ I AFN L L+VL L
Sbjct: 771 LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTL 830
Query: 163 NDNLISFLPDNIFR-FASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDL 221
+ N IS +P+ F SL+H L L NP +C C L
Sbjct: 831 HGNDISSVPEGSFNDLTSLSH-------------------------LALGTNPLHCDCSL 865
Query: 222 LPLKAWLENMPYNIYIGEAICETPSDLYGRLLKET 256
L W++ Y G A C +P + RLL T
Sbjct: 866 RWLSEWVK-AGYK-EPGIARCSSPEPMADRLLLTT 898
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 123 bits (308), Expect = 8e-28
Identities = 138/550 (25%), Positives = 225/550 (40%), Gaps = 70/550 (12%)
Query: 59 SNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNE 118
S+ LN Q L L P L + LHL N+L+++ G F AL L L+NN
Sbjct: 136 SSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNR 195
Query: 119 LKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-F 177
L L F G+ +L L +N + + AF L L+ L+L N +++L +F
Sbjct: 196 LSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGL 255
Query: 178 ASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCD--LLPLKA--WLENMPY 233
A L LD+ N ++ + V + R+ +L L+ N L LKA WL+ + +
Sbjct: 256 AELRELDLSRNALRAIK-ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD-LSH 313
Query: 234 NIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQ 293
N G + +T L G + + + + + D+ L QL + +
Sbjct: 314 NRVAG-LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSF 372
Query: 294 TSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPS 353
L +L T + +++ + AG L N++
Sbjct: 373 EGLGQLEVL---TLDHNQLQEVKAGAFLGLTNVAV------------------------- 404
Query: 354 DLGLSVNCQEKNIQSMSELIPKPLNA-KKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQ 412
+ LS NC ++++ E + + L LH+ G+ + + FT GL L L N
Sbjct: 405 -MNLSGNC----LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNG 459
Query: 413 ITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSM 472
+ I+ L L L L NQ+ L +F GL L+YL L N + E+ A +
Sbjct: 460 LVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPL 519
Query: 473 PNLQLLYLNNNLLKSLPVYIFSGAPLAR---LNLRNNKFMYLPVSGVLDQLQSLTQIDLE 529
L +++N L++LP + APL R L+LRNN + Q L ++ LE
Sbjct: 520 QRAFWLDVSHNRLEALPNSLL--APLGRLRYLSLRNNS-----LRTFTPQPPGLERLWLE 572
Query: 530 GNPWDCTCDLVALK-----------LWVEKLSDG-------IVVKELKCETPVQFANIEL 571
GNPWDC C L AL+ +V+ + +G + C +P + ++L
Sbjct: 573 GNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDL 632
Query: 572 KSLKNEILCP 581
+ L P
Sbjct: 633 RDLSEAHFAP 642
Score = 75.5 bits (184), Expect = 2e-13
Identities = 59/191 (30%), Positives = 81/191 (42%), Gaps = 28/191 (14%)
Query: 342 CPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFE 401
CPA C C LSV C +N+ + + +P
Sbjct: 79 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPG-------------------------- 112
Query: 402 GLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 461
G L L N ++ + F NL++L L L G Q+ L P+ GL NL +L+LE N +
Sbjct: 113 GTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQL 172
Query: 462 KEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSG-APLARLNLRNNKFMYLPVSGVLDQL 520
+ ++ GTF P L L L+NN L L +F G L LNL N LP L
Sbjct: 173 RSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP-DAAFRGL 231
Query: 521 QSLTQIDLEGN 531
SL ++ L GN
Sbjct: 232 GSLRELVLAGN 242
Score = 71.2 bits (173), Expect = 4e-12
Identities = 58/196 (29%), Positives = 90/196 (45%), Gaps = 9/196 (4%)
Query: 51 PNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALK 110
P Q+ + L+ + + L + P+TF S L L +N L IE + GL+ L
Sbjct: 416 PEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELL 475
Query: 111 QLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFL 170
+L L +N+L L F G+ LEYL N + + A L + L ++ N + L
Sbjct: 476 ELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEAL 535
Query: 171 PDNIFR-FASLTHLDIRGNRIQKL-PYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAW- 227
P+++ L +L +R N ++ P LE L LE NPW+C C L L+ +
Sbjct: 536 PNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLE------RLWLEGNPWDCGCPLKALRDFA 589
Query: 228 LENMPYNIYIGEAICE 243
L+N +AICE
Sbjct: 590 LQNPSAVPRFVQAICE 605
Score = 61.6 bits (148), Expect = 3e-09
Identities = 55/166 (33%), Positives = 74/166 (44%), Gaps = 3/166 (1%)
Query: 29 VCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSL 88
VCS + L V C ++ R P + L+ N L+ + P F N S L
Sbjct: 84 VCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNN--LSSVPPAAFQNLSSLGFL 141
Query: 89 HLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIER 148
+L +L ++E A LGL L LHL N+L+ L TF L L N + +E
Sbjct: 142 NLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLED 201
Query: 149 GAFNKLHKLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRIQKL 193
G F L L L L N ++ LPD FR SL L + GNR+ L
Sbjct: 202 GLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 247
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 123 bits (308), Expect = 8e-28
Identities = 138/550 (25%), Positives = 225/550 (40%), Gaps = 70/550 (12%)
Query: 59 SNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNE 118
S+ LN Q L L P L + LHL N+L+++ G F AL L L+NN
Sbjct: 98 SSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNR 157
Query: 119 LKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-F 177
L L F G+ +L L +N + + AF L L+ L+L N +++L +F
Sbjct: 158 LSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGL 217
Query: 178 ASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCD--LLPLKA--WLENMPY 233
A L LD+ N ++ + V + R+ +L L+ N L LKA WL+ + +
Sbjct: 218 AELRELDLSRNALRAIK-ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD-LSH 275
Query: 234 NIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQ 293
N G + +T L G + + + + + D+ L QL + +
Sbjct: 276 NRVAG-LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSF 334
Query: 294 TSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPS 353
L +L T + +++ + AG L N++
Sbjct: 335 EGLGQLEVL---TLDHNQLQEVKAGAFLGLTNVAV------------------------- 366
Query: 354 DLGLSVNCQEKNIQSMSELIPKPLNA-KKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQ 412
+ LS NC ++++ E + + L LH+ G+ + + FT GL L L N
Sbjct: 367 -MNLSGNC----LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNG 421
Query: 413 ITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSM 472
+ I+ L L L L NQ+ L +F GL L+YL L N + E+ A +
Sbjct: 422 LVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPL 481
Query: 473 PNLQLLYLNNNLLKSLPVYIFSGAPLAR---LNLRNNKFMYLPVSGVLDQLQSLTQIDLE 529
L +++N L++LP + APL R L+LRNN + Q L ++ LE
Sbjct: 482 QRAFWLDVSHNRLEALPNSLL--APLGRLRYLSLRNNS-----LRTFTPQPPGLERLWLE 534
Query: 530 GNPWDCTCDLVALK-----------LWVEKLSDG-------IVVKELKCETPVQFANIEL 571
GNPWDC C L AL+ +V+ + +G + C +P + ++L
Sbjct: 535 GNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDL 594
Query: 572 KSLKNEILCP 581
+ L P
Sbjct: 595 RDLSEAHFAP 604
Score = 75.5 bits (184), Expect = 2e-13
Identities = 59/191 (30%), Positives = 81/191 (42%), Gaps = 28/191 (14%)
Query: 342 CPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFE 401
CPA C C LSV C +N+ + + +P
Sbjct: 41 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPG-------------------------- 74
Query: 402 GLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 461
G L L N ++ + F NL++L L L G Q+ L P+ GL NL +L+LE N +
Sbjct: 75 GTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQL 134
Query: 462 KEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSG-APLARLNLRNNKFMYLPVSGVLDQL 520
+ ++ GTF P L L L+NN L L +F G L LNL N LP L
Sbjct: 135 RSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP-DAAFRGL 193
Query: 521 QSLTQIDLEGN 531
SL ++ L GN
Sbjct: 194 GSLRELVLAGN 204
Score = 71.2 bits (173), Expect = 4e-12
Identities = 58/196 (29%), Positives = 90/196 (45%), Gaps = 9/196 (4%)
Query: 51 PNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALK 110
P Q+ + L+ + + L + P+TF S L L +N L IE + GL+ L
Sbjct: 378 PEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELL 437
Query: 111 QLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFL 170
+L L +N+L L F G+ LEYL N + + A L + L ++ N + L
Sbjct: 438 ELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEAL 497
Query: 171 PDNIFR-FASLTHLDIRGNRIQKL-PYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAW- 227
P+++ L +L +R N ++ P LE L LE NPW+C C L L+ +
Sbjct: 498 PNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLE------RLWLEGNPWDCGCPLKALRDFA 551
Query: 228 LENMPYNIYIGEAICE 243
L+N +AICE
Sbjct: 552 LQNPSAVPRFVQAICE 567
Score = 61.6 bits (148), Expect = 3e-09
Identities = 55/166 (33%), Positives = 74/166 (44%), Gaps = 3/166 (1%)
Query: 29 VCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSL 88
VCS + L V C ++ R P + L+ N L+ + P F N S L
Sbjct: 46 VCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNN--LSSVPPAAFQNLSSLGFL 103
Query: 89 HLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIER 148
+L +L ++E A LGL L LHL N+L+ L TF L L N + +E
Sbjct: 104 NLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLED 163
Query: 149 GAFNKLHKLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRIQKL 193
G F L L L L N ++ LPD FR SL L + GNR+ L
Sbjct: 164 GLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 209
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 122 bits (305), Expect = 2e-27
Identities = 125/518 (24%), Positives = 204/518 (39%), Gaps = 109/518 (21%)
Query: 30 CSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLH 89
C+C V V+V P PW N L N + L + FLN S ++L
Sbjct: 35 CTCSRASQVECTGARIVAVPTPL----PW-NAMSLQILNTHITELNESPFLNISALIALR 89
Query: 90 LGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERG 149
+ N+L I GAF L +L+ L L NN+L++L F G+++LE L N + I+
Sbjct: 90 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 149
Query: 150 AFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQ 209
F++ LK L L+ N + ++PD G +H+ + +L
Sbjct: 150 HFSQCSNLKELQLHGNHLEYIPD------------------------GAFDHLVGLTKLN 185
Query: 210 LEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSD 269
L N +I + + +L L E ++ PMGT
Sbjct: 186 LGKNSLT-------------------HISPRVFQHLGNLQVLRLYENRLTDI-PMGTFDG 225
Query: 270 F-DVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQ 328
+++ L Q + G +P +L RL LSN ++SQ
Sbjct: 226 LVNLQELALQQNQIGLLSPGLFHNNHNLQRLY--------------------LSNNHISQ 265
Query: 329 IVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNS 388
+ P P L++ S+ P P N ++L + N
Sbjct: 266 L--------------PPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP-NLRELWLYDNH 310
Query: 389 IKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGL 448
I + + F++ L +L L NQI+ I F+ LT LR L L+ N ++ L +F L
Sbjct: 311 ISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRML 370
Query: 449 HNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKF 508
NLQ + L+ N ++++ F ++ L + L NN L++LP+
Sbjct: 371 ANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPL------------------ 412
Query: 509 MYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWV 546
G+ D L L ++ L NPW C D++ L+ W+
Sbjct: 413 ------GIFDHLGKLCELRLYDNPWRCDSDILPLRNWL 444
Score = 105 bits (261), Expect = 2e-22
Identities = 66/219 (30%), Positives = 109/219 (49%), Gaps = 25/219 (11%)
Query: 60 NFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 119
N L NN ++ L P+ F+ L L N L+ + G F + L++L L +N +
Sbjct: 252 NLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHI 311
Query: 120 KILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FA 178
L + F + L+ L N I +I GAFN L +L+ L L+ N + L N+FR A
Sbjct: 312 SSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLA 371
Query: 179 SLTHLDIRGNRIQKLP-----------------------YIGVLEHIGRVVELQLEDNPW 215
+L ++ ++ NR+++LP +G+ +H+G++ EL+L DNPW
Sbjct: 372 NLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPW 431
Query: 216 NCSCDLLPLKAW-LENMPYNIYIGEAICETPSDLYGRLL 253
C D+LPL+ W L N P +C +P+++ G+ L
Sbjct: 432 RCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSL 470
Score = 69.3 bits (168), Expect = 1e-11
Identities = 50/171 (29%), Positives = 78/171 (45%), Gaps = 8/171 (4%)
Query: 342 CPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFE 401
CP+ C C V C I ++ P P NA L + I +++ S F +
Sbjct: 31 CPSECTCSR-----ASQVECTGARIVAVPT--PLPWNAMSLQILNTHITELNESPFLNIS 83
Query: 402 GLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 461
L L + N+++ I F NL +LR L L N+++ L +F GL +L+ L L N +
Sbjct: 84 ALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQL 143
Query: 462 KEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSG-APLARLNLRNNKFMYL 511
+I F NL+ L L+ N L+ +P F L +LNL N ++
Sbjct: 144 LQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHI 194
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 122 bits (305), Expect = 2e-27
Identities = 125/518 (24%), Positives = 204/518 (39%), Gaps = 109/518 (21%)
Query: 30 CSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLH 89
C+C V V+V P PW N L N + L + FLN S ++L
Sbjct: 29 CTCSRASQVECTGARIVAVPTPL----PW-NAMSLQILNTHITELNESPFLNISALIALR 83
Query: 90 LGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERG 149
+ N+L I GAF L +L+ L L NN+L++L F G+++LE L N + I+
Sbjct: 84 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143
Query: 150 AFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQ 209
F++ LK L L+ N + ++PD G +H+ + +L
Sbjct: 144 HFSQCSNLKELQLHGNHLEYIPD------------------------GAFDHLVGLTKLN 179
Query: 210 LEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSD 269
L N +I + + +L L E ++ PMGT
Sbjct: 180 LGKNSLT-------------------HISPRVFQHLGNLQVLRLYENRLTDI-PMGTFDG 219
Query: 270 F-DVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQ 328
+++ L Q + G +P +L RL LSN ++SQ
Sbjct: 220 LVNLQELALQQNQIGLLSPGLFHNNHNLQRLY--------------------LSNNHISQ 259
Query: 329 IVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNS 388
+ P P L++ S+ P P N ++L + N
Sbjct: 260 L--------------PPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP-NLRELWLYDNH 304
Query: 389 IKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGL 448
I + + F++ L +L L NQI+ I F+ LT LR L L+ N ++ L +F L
Sbjct: 305 ISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRML 364
Query: 449 HNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKF 508
NLQ + L+ N ++++ F ++ L + L NN L++LP+
Sbjct: 365 ANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPL------------------ 406
Query: 509 MYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWV 546
G+ D L L ++ L NPW C D++ L+ W+
Sbjct: 407 ------GIFDHLGKLCELRLYDNPWRCDSDILPLRNWL 438
Score = 105 bits (261), Expect = 2e-22
Identities = 66/219 (30%), Positives = 109/219 (49%), Gaps = 25/219 (11%)
Query: 60 NFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 119
N L NN ++ L P+ F+ L L N L+ + G F + L++L L +N +
Sbjct: 246 NLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHI 305
Query: 120 KILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FA 178
L + F + L+ L N I +I GAFN L +L+ L L+ N + L N+FR A
Sbjct: 306 SSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLA 365
Query: 179 SLTHLDIRGNRIQKLP-----------------------YIGVLEHIGRVVELQLEDNPW 215
+L ++ ++ NR+++LP +G+ +H+G++ EL+L DNPW
Sbjct: 366 NLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPW 425
Query: 216 NCSCDLLPLKAW-LENMPYNIYIGEAICETPSDLYGRLL 253
C D+LPL+ W L N P +C +P+++ G+ L
Sbjct: 426 RCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSL 464
Score = 69.3 bits (168), Expect = 1e-11
Identities = 50/171 (29%), Positives = 78/171 (45%), Gaps = 8/171 (4%)
Query: 342 CPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFE 401
CP+ C C V C I ++ P P NA L + I +++ S F +
Sbjct: 25 CPSECTCSR-----ASQVECTGARIVAVPT--PLPWNAMSLQILNTHITELNESPFLNIS 77
Query: 402 GLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 461
L L + N+++ I F NL +LR L L N+++ L +F GL +L+ L L N +
Sbjct: 78 ALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQL 137
Query: 462 KEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSG-APLARLNLRNNKFMYL 511
+I F NL+ L L+ N L+ +P F L +LNL N ++
Sbjct: 138 LQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHI 188
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 118 bits (296), Expect = 2e-26
Identities = 120/481 (24%), Positives = 204/481 (42%), Gaps = 74/481 (15%)
Query: 110 KQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISF 169
++L LN N + + + F G++ L LQ N I +ERGAF+ + +L+ L LN N +
Sbjct: 64 ERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHM 123
Query: 170 LPDNIFRF-ASLTHLDIRGNRIQKLP---YIGVLEHIGRVVELQLEDNPWNCSCDLLPLK 225
LP+ +F+ +L+ LD+ N IQ +P + G + + LQL+ N +C
Sbjct: 124 LPELLFQNNQALSRLDLSENAIQAIPRKAFRGATD----LKNLQLDKNQISC-------- 171
Query: 226 AWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYT 285
+E + L G + N + + S + L +L + +
Sbjct: 172 --IEEGAFRA------------LRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Query: 286 TPNGHTTQTSLHRLVTKPP-----KTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLT 340
+ H S L +P + + P+ + G+ + + RVP T
Sbjct: 218 FCDCHLAWLS-QWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCT 276
Query: 341 ----PCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSD 396
CPA C C G+ V+C+ K + ++ +P+ + +L +NG IK +
Sbjct: 277 LSSGSCPAMCTCSN-----GI-VDCRGKGLTAIPANLPETMTEIRLELNG--IKSIPPGA 328
Query: 397 FTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYL 456
F+ + L + L +NQI I D F L +L L L GN+I L +F GL+ LQ L L
Sbjct: 329 FSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLL 388
Query: 457 EYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGV 516
N I I F + NL LL L +N ++SL G
Sbjct: 389 NANKINCIRPDAFQDLQNLSLLSLYDNKIQSL------------------------AKGT 424
Query: 517 LDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKN 576
L+++ + L NP+ C C+L L ++ ++ I +C +P + AN + +K+
Sbjct: 425 FTSLRAIQTLHLAQNPFICDCNLKWLADFLR--TNPIETSGARCASPRRLANKRIGQIKS 482
Query: 577 E 577
+
Sbjct: 483 K 483
Score = 116 bits (290), Expect = 1e-25
Identities = 100/398 (25%), Positives = 174/398 (43%), Gaps = 42/398 (10%)
Query: 88 LHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIE 147
+ L N +++I GAF L+++ L+NN++ + D F G+ +L L N I +
Sbjct: 314 IRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLP 373
Query: 148 RGAFNKLHKLKVLILNDNLISFL-PDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVV 206
RG F L+ L++L+LN N I+ + PD +L+ L + N+IQ L G + +
Sbjct: 374 RGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAK-GTFTSLRAIQ 432
Query: 207 ELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGT 266
L L NP+ C C+L L +L P I A C +P L + + + ++
Sbjct: 433 TLHLAQNPFICDCNLKWLADFLRTNP--IETSGARCASPRRLANKRIGQIKSKKF----- 485
Query: 267 GSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNL 326
+ Y P T+ + + + K N+
Sbjct: 486 ----------RCSAKEQYFIPG------------TEDYQLNSECNSDVVCPHKCRCEANV 523
Query: 327 SQIVSYQ-TRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVN 385
+ S + T++P P S L +N E +I + + K + KK++++
Sbjct: 524 VECSSLKLTKIPERIP----------QSTAELRLNNNEISILEATGMFKKLTHLKKINLS 573
Query: 386 GNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIF 445
N + +++ F + LHL +NQ+ I+ +F L LR L L N+I ++ + F
Sbjct: 574 NNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSF 633
Query: 446 SGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNN 483
+GL N++ L L N I +S G FD++ +L L L N
Sbjct: 634 TGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLAN 671
Score = 101 bits (251), Expect = 3e-21
Identities = 115/451 (25%), Positives = 171/451 (37%), Gaps = 100/451 (22%)
Query: 60 NFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 119
N L N + ++ N F L L N++ +E GAF + L++L LN N+L
Sbjct: 62 NTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQL 121
Query: 120 KIL------------RAD------------TFLGIENLEYLQADYNLIKYIERGAFNKLH 155
+L R D F G +L+ LQ D N I IE GAF L
Sbjct: 122 HMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALR 181
Query: 156 KLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPW 215
L+VL LN+N I+ +P + F H+ ++ +L N
Sbjct: 182 GLEVLTLNNNNITTIPVSSF------------------------NHMPKLRTFRLHSNHL 217
Query: 216 NCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRIL 275
C C L L WL P + C P+ L G + E K E G G + +
Sbjct: 218 FCDCHLAWLSQWLRQRPTIGLFTQ--CSGPASLRGLNVAEVQKSEFSCSGQG---EAGRV 272
Query: 276 PPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIV--AGKALSNRNLSQIVSYQ 333
P L +G + P T +GIV GK L
Sbjct: 273 PTCTLSSG-SCPAMCTCS-------------------NGIVDCRGKGL------------ 300
Query: 334 TRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPL-NAKKLHVNGNSIKDV 392
T +P P + + + I+S+ P +++ ++ N I ++
Sbjct: 301 TAIPANLP------------ETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEI 348
Query: 393 DVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQ 452
F L+ L L N+IT + VF L L+ L LN N+I + P+ F L NL
Sbjct: 349 APDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLS 408
Query: 453 YLYLEYNLIKEISAGTFDSMPNLQLLYLNNN 483
L L N I+ ++ GTF S+ +Q L+L N
Sbjct: 409 LLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN 439
Score = 82.4 bits (202), Expect = 2e-15
Identities = 57/184 (30%), Positives = 89/184 (48%), Gaps = 34/184 (18%)
Query: 342 CPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFE 401
CPA C C G +V+C +Q++ + IP+ N ++L +NGN+I + +DF +
Sbjct: 34 CPALCTCT------GTTVDCHGTGLQAIPKNIPR--NTERLELNGNNITRIHKNDFAGLK 85
Query: 402 GLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEI----------------- 444
L +L L NQI ++ F ++ L RL LN NQ+ L PE+
Sbjct: 86 QLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHML-PELLFQNNQALSRLDLSENA 144
Query: 445 --------FSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGA 496
F G +L+ L L+ N I I G F ++ L++L LNNN + ++PV F+
Sbjct: 145 IQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHM 204
Query: 497 PLAR 500
P R
Sbjct: 205 PKLR 208
Score = 80.5 bits (197), Expect = 6e-15
Identities = 65/233 (27%), Positives = 104/233 (44%), Gaps = 33/233 (14%)
Query: 17 NADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYP 76
N++ + V + C C + NV V C + + + + P + LN NN ++IL
Sbjct: 504 NSECNSDVVCPHKCRCEA--NV--VECSSLKLTKIPERIPQSTAELRLN--NNEISILEA 557
Query: 77 N-TFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEY 135
F +H ++L NNK+ IE GAF G +++ +LHL N+L+ +R+ F G++ L
Sbjct: 558 TGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRT 617
Query: 136 LQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPY 195
L N I I +F L +++L L DN I+ + F + +Q L
Sbjct: 618 LMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAF------------DTLQSLST 665
Query: 196 IGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDL 248
+ +L NP+NC+C L L WL I G C+ P L
Sbjct: 666 LNLLA------------NPFNCNCQLAWLGGWLRKR--KIVTGNPRCQNPDFL 704
Score = 75.9 bits (185), Expect = 1e-13
Identities = 96/413 (23%), Positives = 153/413 (37%), Gaps = 82/413 (19%)
Query: 57 PWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNN 116
P+ ++ NN + + P+ F SL L NK+ ++ G F GL L+ L LN
Sbjct: 331 PYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNA 390
Query: 117 NELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR 176
N++ +R D F ++NL L N I+ + +G F L ++ L
Sbjct: 391 NKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTL---------------- 434
Query: 177 FASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIY 236
L NP+ C C+L L +L P I
Sbjct: 435 --------------------------------HLAQNPFICDCNLKWLADFLRTNP--IE 460
Query: 237 IGEAICETPSDLYGRLLKE--------TNKQELCPMGTGSDFDVRILPPSQLENGYTTPN 288
A C +P L + + + + K++ GT D+ + S+ + P
Sbjct: 461 TSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGT-EDYQLN----SECNSDVVCP- 514
Query: 289 GHTTQTSLHRLVTKPPKTTN-PSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCF 347
H + + + K T P +I A L+N +S + + F
Sbjct: 515 -HKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEA------------TGMF 561
Query: 348 CK-THPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLL 406
K TH + LS N K + + +LH+ N ++ + F +GL L
Sbjct: 562 KKLTHLKKINLSNN---KVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTL 618
Query: 407 HLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYN 459
L +N+I+ I D F L N+R L L NQI + P F L +L L L N
Sbjct: 619 MLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLAN 671
Score = 70.1 bits (170), Expect = 8e-12
Identities = 93/383 (24%), Positives = 152/383 (39%), Gaps = 66/383 (17%)
Query: 111 QLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFL 170
+L LNNNE+ IL A G F KL LK + L++N +S +
Sbjct: 544 ELRLNNNEISILEAT-----------------------GMFKKLTHLKKINLSNNKVSEI 580
Query: 171 PDNIFR-FASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLE 229
D F AS++ L + N+++ + G+ + + L L +N SC L
Sbjct: 581 EDGAFEGAASVSELHLTANQLESIRS-GMFRGLDGLRTLMLRNN--RISCIHNDSFTGLR 637
Query: 230 NMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNG 289
N+ RLL + Q + + G+ FD L N P
Sbjct: 638 NV-------------------RLLSLYDNQ-ITTVSPGA-FDT--LQSLSTLNLLANPFN 674
Query: 290 HTTQTSL-------HRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPC 342
Q + ++VT P+ NP + I + + P C
Sbjct: 675 CNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQC 734
Query: 343 PAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEG 402
P C C L V C K+++++ + IPK N +L+++GN V + F+
Sbjct: 735 PQECAC------LDTVVRCSNKHLRALPKGIPK--NVTELYLDGNQFTLVP-GQLSTFKY 785
Query: 403 LDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIK 462
L L+ L +N+I+ + F N++ L L L+ N ++ + P F GL +L+ L L N I
Sbjct: 786 LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIS 845
Query: 463 EISAGTFDSMPNLQLLYLNNNLL 485
+ G F + +L L + N L
Sbjct: 846 TLQEGIFADVTSLSHLAIGANPL 868
Score = 51.2 bits (121), Expect = 4e-06
Identities = 52/177 (29%), Positives = 73/177 (41%), Gaps = 35/177 (19%)
Query: 84 HAVSLHLGNNKLQNIEGGAFLGLSALKQLHL---NNNELKILRADTFLGIENLEYLQADY 140
+ L+L N+ + G LS K L L +NN++ L +F + L L Y
Sbjct: 762 NVTELYLDGNQFTLVPGQ----LSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSY 817
Query: 141 NLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRIQKLPYIGVL 199
N ++ I AF L L++L L+ N IS L + IF SL+HL I
Sbjct: 818 NALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGA------------ 865
Query: 200 EHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKET 256
NP C C L L +W++ Y G A C P D+ G+LL T
Sbjct: 866 -------------NPLYCDCHLRWLSSWVKT-GYK-EPGIARCAGPQDMEGKLLLTT 907
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/78 (32%), Positives = 41/78 (52%)
Query: 64 LNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILR 123
++ NN ++ L ++F N S +L L N LQ I AF GL +L+ L L+ N++ L+
Sbjct: 789 VDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQ 848
Query: 124 ADTFLGIENLEYLQADYN 141
F + +L +L N
Sbjct: 849 EGIFADVTSLSHLAIGAN 866
>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
sapiens]
Length = 660
Score = 103 bits (256), Expect = 9e-22
Identities = 84/283 (29%), Positives = 132/283 (46%), Gaps = 37/283 (13%)
Query: 359 VNCQEKNIQSMSEL-IPKPLNAKKLHVNGNSIKDVDVSD--FTDFEGLDLL-----HLGS 410
++ QE NIQ++S + + L ++LH++ NSI V V D F + L LL HL S
Sbjct: 114 LHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSS 173
Query: 411 ----------------NQITVIKGDVFHNLTNLRRLYLNGNQIER--LYPEIFSGLHNLQ 452
N+I VI F NLT+L RL ++GN + + FS L L+
Sbjct: 174 VPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLK 233
Query: 453 YLYLEYNLIKEISAGTFDSMPNLQL--LYLNNNLLKSLPVYIFSGA-PLARLNLRNNKFM 509
E+++++ + +P L LYL +N + +P+ FS L RL++ NN+
Sbjct: 234 ----EFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLR 289
Query: 510 YLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANI 569
L GV D L +L Q+ NPW C C + + W++ + + V+ C+ P Q +
Sbjct: 290 ML-TQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGM 348
Query: 570 ELKSLKNEIL-CPKLLNKPSAPFTSPAPAITFTTPLGPIRSPP 611
++ L +L CP P P +PAP+ T P S P
Sbjct: 349 AVRELNMNLLSCP--TTTPGLPLFTPAPSTASPTTQPPTLSIP 389
Score = 76.3 bits (186), Expect = 1e-13
Identities = 76/294 (25%), Positives = 119/294 (40%), Gaps = 53/294 (18%)
Query: 64 LNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNI--EGGAFLGLSALKQLHLNNN---- 117
L+ Q N + + LHL +N + + E GAF +LK L L+ N
Sbjct: 114 LHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSS 173
Query: 118 -------ELKILRAD----------TFLGIENLEYLQADYNLI--KYIERGAFNKLHKLK 158
+L+ LR D F + +LE L D NL+ K I G F+ L KLK
Sbjct: 174 VPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLK 233
Query: 159 V----------------------LILNDNLISFLPDNIF-RFASLTHLDIRGNRIQKLPY 195
L L DN I+ +P F L LDI N+++ L
Sbjct: 234 EFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQ 293
Query: 196 IGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKE 255
GV +++ + +L +NPW C C + + WL+ +P ++ + +C+ P + G ++E
Sbjct: 294 -GVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRE 352
Query: 256 TNKQEL-CPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTN 308
N L CP T + + P+ TT + + R T P TT+
Sbjct: 353 LNMNLLSCPTTTPG---LPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTS 403
Score = 46.6 bits (109), Expect = 1e-04
Identities = 56/223 (25%), Positives = 93/223 (41%), Gaps = 61/223 (27%)
Query: 334 TRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVD 393
++V L CP+ C C + V C E+++ S+ IP
Sbjct: 28 SQVSKLLACPSVCRCDRN------FVYCNERSLTSVPLGIP------------------- 62
Query: 394 VSDFTDFEGLDLLHLGSNQITVIKGDV-FHNLTNLRRLYLNGNQIERL---YPEIFSGLH 449
EG+ +L+L +NQI HN+ ++ +YL GNQ++ P+ LH
Sbjct: 63 -------EGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLH 115
Query: 450 ------------------NLQYLYLEYNLIKEISA--GTFDSMPNLQLLYLNNNLLKSLP 489
L+ L+L+ N I + G F +L+LL+L+ N L S+P
Sbjct: 116 LQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVP 175
Query: 490 VYIFSGAPLARLNLRNNKFMYLPVSGVLDQ-LQSLTQIDLEGN 531
V G P+ LR ++ +S + Q L SL ++ ++GN
Sbjct: 176 V----GLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGN 214
Score = 38.5 bits (88), Expect = 0.026
Identities = 32/112 (28%), Positives = 52/112 (46%), Gaps = 2/112 (1%)
Query: 57 PWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNN 116
P ++ L Q+N +N + F N L + NN+L+ + G F LS LKQL N
Sbjct: 250 PGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARN 309
Query: 117 NELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLIS 168
N E L+Y+ + N+ ++ +G ++ + V LN NL+S
Sbjct: 310 NPW-FCDCSIKWVTEWLKYIPSSLNVRGFMCQGP-EQVRGMAVRELNMNLLS 359
>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
sapiens]
Length = 581
Score = 102 bits (253), Expect = 2e-21
Identities = 91/326 (27%), Positives = 146/326 (44%), Gaps = 24/326 (7%)
Query: 382 LHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLY 441
LH+ NS++ + V F D L+LL LG N+I + +VF + L+ L+L NQ +L
Sbjct: 162 LHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLN 221
Query: 442 PEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLP-VYIFSGAP-LA 499
+F L +LQ LYL++N I I + +LQ L L+ N +++ +F P L
Sbjct: 222 LALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQ 281
Query: 500 RLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELK 559
RLNL +NK ++ +LD SL I L GN W+C+ ++ +L W++ G+ +
Sbjct: 282 RLNLDSNKLTFIG-QEILDSWISLNDISLAGNIWECSRNICSLVNWLKSFK-GLRENTII 339
Query: 560 CETPVQFANIE-LKSLKNEILCPK----------LLNKPSAPFTSPAPAITFTTPLGPI- 607
C +P + + + ++KN +C K L KP+ P P PL P
Sbjct: 340 CASPKELQGVNVIDAVKNYSICGKSTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTV 399
Query: 608 -RSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPDCGSMQL 666
+ PG +S ++ +V + +LV +L V + QL
Sbjct: 400 GATEPGPETDADAEHISFHKIIAGSVALFLSVLVILL-------VIYVSWKRYPASMKQL 452
Query: 667 QLRKHDHKTNKKDGLSTEAFIPQTIE 692
Q R + KK S + P T E
Sbjct: 453 QQRSLMRRHRKKKRQSLKQMTPSTQE 478
Score = 75.9 bits (185), Expect = 1e-13
Identities = 64/213 (30%), Positives = 98/213 (46%), Gaps = 30/213 (14%)
Query: 342 CPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIP---------------------KPLNAK 380
CP C C+ G V C+ + +Q + I K LN
Sbjct: 34 CPKGCRCE------GKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQL 87
Query: 381 K-LHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIER 439
L+++ N I ++D + F L L L SN+I+ + F +TNLR L L+ NQ+
Sbjct: 88 TWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHS 147
Query: 440 LYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSG-APL 498
L E F GL L L+L N ++ I F NL+LL L N ++SL +F+G L
Sbjct: 148 LGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRL 207
Query: 499 ARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGN 531
L+L +N+F L ++ + +L SL + L+ N
Sbjct: 208 KELHLEHNQFSKLNLA-LFPRLVSLQNLYLQWN 239
Score = 68.9 bits (167), Expect = 2e-11
Identities = 54/170 (31%), Positives = 83/170 (48%), Gaps = 3/170 (1%)
Query: 64 LNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILR 123
L+ + N L L N F + L+L +N + NI+ AF G+ LK+L L++N +
Sbjct: 66 LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFL 125
Query: 124 ADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FASLTH 182
+TF + NL L YN + + F L KL L L N + +P IF+ +L
Sbjct: 126 NNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLEL 185
Query: 183 LDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWN-CSCDLLPLKAWLENM 231
LD+ NRI+ L V + R+ EL LE N ++ + L P L+N+
Sbjct: 186 LDLGYNRIRSLAR-NVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNL 234
Score = 67.0 bits (162), Expect = 7e-11
Identities = 58/219 (26%), Positives = 104/219 (47%), Gaps = 10/219 (4%)
Query: 64 LNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILR 123
L+ ++N L + F + + L LG N+++++ F G+ LK+LHL +N+ L
Sbjct: 162 LHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLN 221
Query: 124 ADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLI-SFLPDNIFR-FASLT 181
F + +L+ L +N I I + L+ L L+ N I +F ++F+ +L
Sbjct: 222 LALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQ 281
Query: 182 HLDIRGNRIQKLPYIG--VLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGE 239
L++ N KL +IG +L+ + ++ L N W CS ++ L WL++ +
Sbjct: 282 RLNLDSN---KLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLKSFK-GLRENT 337
Query: 240 AICETPSDLYG-RLLKETNKQELCPMGTGSDFDV-RILP 276
IC +P +L G ++ +C T FD+ R LP
Sbjct: 338 IICASPKELQGVNVIDAVKNYSICGKSTTERFDLARALP 376
Score = 48.5 bits (114), Expect = 3e-05
Identities = 33/110 (30%), Positives = 52/110 (47%), Gaps = 1/110 (0%)
Query: 86 VSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKY 145
+ L L N LQ ++ F GL+ L L+L++N + + + F GI L+ L N I Y
Sbjct: 64 LGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISY 123
Query: 146 IERGAFNKLHKLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRIQKLP 194
F + L+ L L+ N + L FR L L +R N ++ +P
Sbjct: 124 FLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIP 173
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 98.2 bits (243), Expect = 3e-20
Identities = 67/208 (32%), Positives = 98/208 (47%), Gaps = 30/208 (14%)
Query: 382 LHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLY 441
L ++ N+I + S F E L L+LGSN +T + + F L +LRRL L+ N IE +
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
Query: 442 PEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFS------- 494
P F GL NL+YL L+ + I+ ++ F + NL+ L L++N L++L FS
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
Query: 495 -------------------GAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDC 535
GA L LNL N L VL L SL + NPW+C
Sbjct: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALH-PRVLKPLSSLIHLQANSNPWEC 363
Query: 536 TCDLVALKLWVEKLSDGIVVKELKCETP 563
C L+ L+ W L+ + + C+ P
Sbjct: 364 NCKLLGLRDW---LASSAITLNIYCQNP 388
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/222 (28%), Positives = 106/222 (47%), Gaps = 34/222 (15%)
Query: 64 LNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILR 123
L+ NN + + + F + + L+LG+N L + AF L +L++L L++N ++ ++
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
Query: 124 ADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRF------ 177
F G+ NLEYL + I+ + R F+ ++ LK LIL+ N + L + F
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
Query: 178 --------------------ASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNC 217
ASL L++ N + L + VL+ + ++ LQ NPW C
Sbjct: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTAL-HPRVLKPLSSLIHLQANSNPWEC 363
Query: 218 SCDLLPLKAWLEN--MPYNIYIGEAICETPSDLYGRLLKETN 257
+C LL L+ WL + + NIY C+ P + GR L+ N
Sbjct: 364 NCKLLGLRDWLASSAITLNIY-----CQNPPSMRGRALRYIN 400
Score = 86.7 bits (213), Expect = 8e-17
Identities = 58/177 (32%), Positives = 92/177 (51%), Gaps = 4/177 (2%)
Query: 356 GLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITV 415
G +NC+ + S+ + P+ + L++ GN+I ++ S+ T L L+L ++ I
Sbjct: 41 GRQINCRNLGLSSIPKNFPE--STVFLYLTGNNISYINESELTGLHSLVALYLDNSNILY 98
Query: 416 IKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNL 475
+ F L +L L+LN N I+RL P IF GL NL+ LYL+YN + + G F+ + ++
Sbjct: 99 VYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSV 158
Query: 476 QLLYLNNNLLKSLPVYIFSGAPLAR-LNLRNNKFMYLPVSGVLDQLQSLTQIDLEGN 531
Q L L N L L F G R L+L NN + + SG L++L + L N
Sbjct: 159 QYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESG-FQHLENLACLYLGSN 214
Score = 63.2 bits (152), Expect = 1e-09
Identities = 41/135 (30%), Positives = 63/135 (46%), Gaps = 1/135 (0%)
Query: 60 NFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 119
+ Y L NNF+ L P F + +L+L N++ + G F L +++ L+L N L
Sbjct: 109 HLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRL 168
Query: 120 KILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FA 178
+L + TF+G+ L L N I I F L L L L N ++ +P N F
Sbjct: 169 TVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLK 228
Query: 179 SLTHLDIRGNRIQKL 193
SL L + N I+ +
Sbjct: 229 SLRRLSLSHNPIEAI 243
Score = 61.6 bits (148), Expect = 3e-09
Identities = 45/177 (25%), Positives = 83/177 (46%), Gaps = 3/177 (1%)
Query: 39 LYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNI 98
LY+ +S ++L S L N+ + +YP F+ H L L NN ++ +
Sbjct: 65 LYLTGNNISYINESELTGLHS-LVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRL 123
Query: 99 EGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLK 158
+ G F GL L+ L+L N++ + F + +++YL N + + G F + L+
Sbjct: 124 DPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALR 183
Query: 159 VLILNDNLISFLPDNIFR-FASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNP 214
+L L++N I + ++ F+ +L L + N + K+P E + + L L NP
Sbjct: 184 ILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVP-SNAFEVLKSLRRLSLSHNP 239
Score = 55.1 bits (131), Expect = 3e-07
Identities = 33/109 (30%), Positives = 58/109 (53%), Gaps = 1/109 (0%)
Query: 86 VSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKY 145
V L+L N + I GL +L L+L+N+ + + F+ + +L +L + N IK
Sbjct: 63 VFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKR 122
Query: 146 IERGAFNKLHKLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRIQKL 193
++ G F L L+ L L N +SF+P +F S+ +L+++ NR+ L
Sbjct: 123 LDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVL 171
Score = 52.8 bits (125), Expect = 1e-06
Identities = 38/135 (28%), Positives = 66/135 (48%), Gaps = 1/135 (0%)
Query: 60 NFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 119
N +L Q N ++ + F + L+L N+L + G F+G+ AL+ L L+NN +
Sbjct: 133 NLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNI 192
Query: 120 KILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FA 178
+ F +ENL L N + + AF L L+ L L+ N I + F+ A
Sbjct: 193 LRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLA 252
Query: 179 SLTHLDIRGNRIQKL 193
+L +L ++ +RI+ +
Sbjct: 253 NLEYLLLKNSRIRNV 267
>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
sapiens]
Length = 674
Score = 97.8 bits (242), Expect = 4e-20
Identities = 74/249 (29%), Positives = 125/249 (50%), Gaps = 34/249 (13%)
Query: 359 VNCQEKNIQSMSE--LIPKPLNAKKLHVNGNSIKDVDVSD--FTDFEGLDLLHLGSNQIT 414
++ Q+ N+++++ L PL +KLH++ NS+ V + + F D + L LL L N ++
Sbjct: 132 LHLQDNNVRTIARDSLARIPL-LEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLS 190
Query: 415 VIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI--KEISAGTFDSM 472
I + H L LR L+ N+I + F GL++L+ L L+ NL+ + I+ TF +
Sbjct: 191 SIPSGLPHTLEELR---LDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRL 247
Query: 473 PNL----------------------QLLYLNNNLLKSLPVYIFSGA-PLARLNLRNNKFM 509
NL Q LYL +N + +P + L RL+L NN
Sbjct: 248 QNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLT 307
Query: 510 YLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANI 569
LP G+ D L +L Q+ L NPW C C+L+ L+ WV+ + + V+ L C+ P + +
Sbjct: 308 TLP-RGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGM 366
Query: 570 ELKSLKNEI 578
+K + +E+
Sbjct: 367 AIKDITSEM 375
Score = 79.0 bits (193), Expect = 2e-14
Identities = 64/221 (28%), Positives = 106/221 (47%), Gaps = 10/221 (4%)
Query: 88 LHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRA--DTFLGIENLEYLQADYNLIKY 145
L L +N++ I AF GL++L++L L+ N L R DTF ++NL L N +
Sbjct: 203 LRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAA 262
Query: 146 IERGAFNKLHKLKVLILNDNLISFLPDN-IFRFASLTHLDIRGNRIQKLPYIGVLEHIGR 204
+ L+ L L DN IS +P N + + L LD+ N + LP G+ + +G
Sbjct: 263 PPLNLPSA--HLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPR-GLFDDLGN 319
Query: 205 VVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKE-TNKQELCP 263
+ +L L +NPW C C+L+ L+ W++ + + +C+ P + G +K+ T++ + C
Sbjct: 320 LAQLLLRNNPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDEC- 378
Query: 264 MGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPP 304
TG V + + + T Q SL L K P
Sbjct: 379 FETGPQGGVANAAAKTTASNHASAT--TPQGSLFTLKAKRP 417
Score = 33.1 bits (74), Expect = 1.1
Identities = 24/80 (30%), Positives = 35/80 (43%), Gaps = 4/80 (5%)
Query: 42 NCEKVSVYRPNQLKPPWS----NFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQN 97
N ++S+ R + PP + + L Q+N ++ + NT L L NN L
Sbjct: 249 NLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTT 308
Query: 98 IEGGAFLGLSALKQLHLNNN 117
+ G F L L QL L NN
Sbjct: 309 LPRGLFDDLGNLAQLLLRNN 328
>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
Length = 473
Score = 97.1 bits (240), Expect = 6e-20
Identities = 70/203 (34%), Positives = 96/203 (47%), Gaps = 6/203 (2%)
Query: 68 NNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTF 127
N L + P TF +LHL LQ + G F GL+AL+ L+L +N L+ L DTF
Sbjct: 115 NAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTF 174
Query: 128 LGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FASLTHLDIR 186
+ NL +L N I + AF LH L L+L+ N ++ + + FR L L +
Sbjct: 175 RDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLF 234
Query: 187 GNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPS 246
N + LP L + + L+L DNPW C C PL AWL+ + E C P
Sbjct: 235 ANNLSALP-TEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQK--FRGSSSEVPCSLPQ 291
Query: 247 DLYGRLLKETNKQEL--CPMGTG 267
L GR LK +L C + TG
Sbjct: 292 RLAGRDLKRLAANDLQGCAVATG 314
Score = 95.1 bits (235), Expect = 2e-19
Identities = 76/283 (26%), Positives = 120/283 (42%), Gaps = 56/283 (19%)
Query: 341 PCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDF 400
PCP C C P ++ +C ++ +Q++ IP ++++ ++GN I V + F
Sbjct: 26 PCPGACVCYNEPK---VTTSCPQQGLQAVPVGIPAA--SQRIFLHGNRISHVPAASFRAC 80
Query: 401 EGLDLLHLGSN-------------------------QITVIKGDVFHNLTNLRRLYLNGN 435
L +L L SN Q+ + FH L L L+L+
Sbjct: 81 RNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRC 140
Query: 436 QIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSG 495
++ L P +F GL LQYLYL+ N ++ + TF + NL L+L+ N + S+P F G
Sbjct: 141 GLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRG 200
Query: 496 A-PLARLNLRNNKF----------------MYLPVSGV-------LDQLQSLTQIDLEGN 531
L RL L N+ +YL + + L L++L + L N
Sbjct: 201 LHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
Query: 532 PWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSL 574
PW C C L W++K E+ C P + A +LK L
Sbjct: 261 PWVCDCRARPLWAWLQKFRGS--SSEVPCSLPQRLAGRDLKRL 301
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 95.5 bits (236), Expect = 2e-19
Identities = 66/220 (30%), Positives = 108/220 (49%), Gaps = 7/220 (3%)
Query: 368 SMSELIPKPLNA----KKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHN 423
++SEL P+ + ++L + N+I + +S F L L L N + V+ +F +
Sbjct: 228 NISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAH 287
Query: 424 LTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNN 483
L L L NQ+E + F+ L NL+ L L YN I + AG F + L LYL +N
Sbjct: 288 TPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSN 347
Query: 484 LLKSLPVYIFSG-APLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVAL 542
L +L +F + L L+L N+ LP G+ D +L + L GNPW C C L L
Sbjct: 348 NLTALHPALFQNLSKLELLSLSKNQLTTLP-EGIFDTNYNLFNLALHGNPWQCDCHLAYL 406
Query: 543 KLWVEKLSDGIVVKELKCETPVQFANIELKSL-KNEILCP 581
W+++ +D ++ + C P + +L + +++CP
Sbjct: 407 FNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVCP 446
Score = 83.6 bits (205), Expect = 7e-16
Identities = 58/200 (29%), Positives = 92/200 (46%), Gaps = 3/200 (1%)
Query: 67 QNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADT 126
Q N + L + F + + L L N L+ + G F L L L +N+L+ + T
Sbjct: 249 QRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGT 308
Query: 127 FLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FASLTHLDI 185
F + NL L YN I ++ G F L +L L L N ++ L +F+ + L L +
Sbjct: 309 FAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSL 368
Query: 186 RGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETP 245
N++ LP G+ + + L L NPW C C L L WL+ + + C P
Sbjct: 369 SKNQLTTLPE-GIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGP 427
Query: 246 SDLYGRLLKETN-KQELCPM 264
+ L G+++ N KQ +CP+
Sbjct: 428 AYLKGQVVPALNEKQLVCPV 447
Score = 76.3 bits (186), Expect = 1e-13
Identities = 61/217 (28%), Positives = 102/217 (47%), Gaps = 19/217 (8%)
Query: 322 SNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMS------ELIPK 375
SN NL+++V T++ C+ P G ++ + S +
Sbjct: 71 SNPNLTKVVFLNTQL-----------CQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSN 119
Query: 376 PLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGN 435
+ KL +N N ++ + F L+ LHL NQ+ + +F LT+L+ L L N
Sbjct: 120 LTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQN 179
Query: 436 QIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSG 495
+ +L E+F L +LQ L L N + + G F + +LQ L+L++N + LP +FS
Sbjct: 180 LLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQ 239
Query: 496 A-PLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGN 531
L RL L+ N +LP+S + L +LT + L+ N
Sbjct: 240 LFCLERLWLQRNAITHLPLS-IFASLGNLTFLSLQWN 275
Score = 72.4 bits (176), Expect = 2e-12
Identities = 52/176 (29%), Positives = 89/176 (50%), Gaps = 3/176 (1%)
Query: 358 SVNCQEKNIQSMSELIPKPL-NAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVI 416
S++ Q +Q++ + +PL + K L++ N + + F L L L +N ++ +
Sbjct: 149 SLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGL 208
Query: 417 KGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQ 476
VF L +L+ L+L+ N I L P++FS L L+ L+L+ N I + F S+ NL
Sbjct: 209 PQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLT 268
Query: 477 LLYLNNNLLKSLPVYIFSGAP-LARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGN 531
L L N+L+ LP +F+ P L L+L +N+ + G L +L + L N
Sbjct: 269 FLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQ-LETVAEGTFAHLSNLRSLMLSYN 323
Score = 65.9 bits (159), Expect = 2e-10
Identities = 44/128 (34%), Positives = 67/128 (52%), Gaps = 2/128 (1%)
Query: 68 NNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTF 127
++FLN L N F N + L L N L+ + G F L+AL+ LHL N+L+ L F
Sbjct: 107 SSFLN-LSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLF 165
Query: 128 LGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIF-RFASLTHLDIR 186
+ +L+ L NL+ + F+ L L+ L L++N +S LP +F + SL L +
Sbjct: 166 QPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLD 225
Query: 187 GNRIQKLP 194
N I +LP
Sbjct: 226 SNNISELP 233
Score = 64.7 bits (156), Expect = 3e-10
Identities = 51/154 (33%), Positives = 76/154 (49%), Gaps = 7/154 (4%)
Query: 64 LNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILR 123
LNF N L L F + + SLHL N+LQ + F L+ LK L+L N L L
Sbjct: 128 LNF--NMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185
Query: 124 ADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIF-RFASLTH 182
+ F + +L+ L+ N + + +G F KL L+ L L+ N IS LP +F + L
Sbjct: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245
Query: 183 LDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWN 216
L ++ N I LP + + +G + L L+ WN
Sbjct: 246 LWLQRNAITHLP-LSIFASLGNLTFLSLQ---WN 275
Score = 59.3 bits (142), Expect = 1e-08
Identities = 47/155 (30%), Positives = 69/155 (44%), Gaps = 2/155 (1%)
Query: 60 NFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 119
N + F N L P+ F L + + N+ F L++L +L LN N L
Sbjct: 74 NLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNML 133
Query: 120 KILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FA 178
+ L F + LE L N ++ + R F L LK L L NL++ LP+ +F
Sbjct: 134 EALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLT 193
Query: 179 SLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDN 213
SL L + N + LP GV +G + EL L+ N
Sbjct: 194 SLQTLKLSNNALSGLPQ-GVFGKLGSLQELFLDSN 227
Score = 56.2 bits (134), Expect = 1e-07
Identities = 45/164 (27%), Positives = 70/164 (42%), Gaps = 2/164 (1%)
Query: 51 PNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALK 110
P +L P ++ LN N L L F + +L L NN L + G F L +L+
Sbjct: 161 PRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQ 220
Query: 111 QLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFL 170
+L L++N + L F + LE L N I ++ F L L L L N++ L
Sbjct: 221 ELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVL 280
Query: 171 PDNIFRFA-SLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDN 213
P +F L L + N+++ + G H+ + L L N
Sbjct: 281 PAGLFAHTPCLVGLSLTHNQLETVAE-GTFAHLSNLRSLMLSYN 323
Score = 47.0 bits (110), Expect = 7e-05
Identities = 45/176 (25%), Positives = 71/176 (40%), Gaps = 33/176 (18%)
Query: 338 PLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDF 397
P PCP C C V C ++ + ++ IP P + V
Sbjct: 18 PAQPCPMGCDCFVQ------EVFCSDEELATVPLDIP-PYTKNIIFVE------------ 58
Query: 398 TDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLE 457
T F L+ GSN NL ++ Q+ + P+ F GL L+ L +
Sbjct: 59 TSFTTLETRAFGSNP-------------NLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVT 105
Query: 458 YNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSG-APLARLNLRNNKFMYLP 512
+ +S F ++ +L L LN N+L++LP +F A L L+L+ N+ LP
Sbjct: 106 GSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALP 161
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 93.6 bits (231), Expect = 7e-19
Identities = 115/470 (24%), Positives = 193/470 (41%), Gaps = 90/470 (19%)
Query: 131 ENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFL-PDNIFRFASLTHLDIRGNR 189
E + ++ + N IK I GAF+ KL+ + L++N IS L PD SL L + GN+
Sbjct: 300 ETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNK 359
Query: 190 IQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLY 249
I +LP + E + + L L N NC L + A+ + N+ LY
Sbjct: 360 ITELPK-SLFEGLFSLQLLLLNANKINC----LRVDAFQDLHNLNLL----------SLY 404
Query: 250 GRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNP 309
NK + GT S P ++ + N L L TNP
Sbjct: 405 D------NKLQTIAKGTFS-------PLRAIQTMHLAQNPFICDCHLKWLADY--LHTNP 449
Query: 310 SKISGI--VAGKALSNRNLSQIVSYQTRVP-------PLTP---------------CPAP 345
+ SG + + L+N+ + QI S + R P T CP
Sbjct: 450 IETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEK 509
Query: 346 CFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSD-FTDFEGLD 404
C C+ G +V+C + + + E IP+ +L +N N ++ + F L
Sbjct: 510 CRCE------GTTVDCSNQKLNKIPEHIPQ--YTAELRLNNNEFTVLEATGIFKKLPQLR 561
Query: 405 LLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEI 464
++ +N+IT I+ F + + + L N++E + ++F GL +L+ L L N I +
Sbjct: 562 KINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCV 621
Query: 465 SAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLT 524
+F + +++LL L +N + ++ AP G D L SL+
Sbjct: 622 GNDSFIGLSSVRLLSLYDNQITTV-------AP-----------------GAFDTLHSLS 657
Query: 525 QIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSL 574
++L NP++C C L L W+ K IV +C+ P I ++ +
Sbjct: 658 TLNLLANPFNCNCYLAWLGEWLRK--KRIVTGNPRCQKPYFLKEIPIQDV 705
Score = 93.2 bits (230), Expect = 9e-19
Identities = 112/437 (25%), Positives = 162/437 (37%), Gaps = 99/437 (22%)
Query: 60 NFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 119
N L+ N + + F H L L NK+ IE GAF L L++L LN N L
Sbjct: 56 NTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHL 115
Query: 120 ------------KILRAD------------TFLGIENLEYLQADYNLIKYIERGAFNKLH 155
K+ R D F G +++ LQ DYN I IE GAF L
Sbjct: 116 QLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALR 175
Query: 156 KLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPW 215
L+VL LN+N NI R + + H+ ++ +L N
Sbjct: 176 DLEVLTLNNN-------NITRLS-----------------VASFNHMPKLRTFRLHSNNL 211
Query: 216 NCSCDLLPLKAWLENMP-YNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRI 274
C C L L WL P +Y C PS L G + E K+E
Sbjct: 212 YCDCHLAWLSDWLRQRPRVGLY---TQCMGPSHLRGHNVAEVQKREF------------- 255
Query: 275 LPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSN------RNLSQ 328
+GH + + V P S GK L+ +++
Sbjct: 256 -----------VCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITE 304
Query: 329 IVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIP------KPLNAKKL 382
I Q + + P + K DL + +SEL P + LN+ L
Sbjct: 305 IRLEQNTIKVIPPGAFSPYKKLRRIDL---------SNNQISELAPDAFQGLRSLNSLVL 355
Query: 383 HVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYP 442
+ GN I ++ S F L LL L +N+I ++ D F +L NL L L N+++ +
Sbjct: 356 Y--GNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAK 413
Query: 443 EIFSGLHNLQYLYLEYN 459
FS L +Q ++L N
Sbjct: 414 GTFSPLRAIQTMHLAQN 430
Score = 92.8 bits (229), Expect = 1e-18
Identities = 91/397 (22%), Positives = 166/397 (41%), Gaps = 38/397 (9%)
Query: 88 LHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIE 147
+ L N ++ I GAF L+++ L+NN++ L D F G+ +L L N I +
Sbjct: 305 IRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELP 364
Query: 148 RGAFNKLHKLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRIQKLPYIGVLEHIGRVV 206
+ F L L++L+LN N I+ L + F+ +L L + N++Q + G + +
Sbjct: 365 KSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAK-GTFSPLRAIQ 423
Query: 207 ELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGT 266
+ L NP+ C C L L +L P I A C +P L + + + ++
Sbjct: 424 TMHLAQNPFICDCHLKWLADYLHTNP--IETSGARCTSPRRLANKRIGQIKSKKF----- 476
Query: 267 GSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNL 326
+ Y P ++ L + G SN+ L
Sbjct: 477 ----------RCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVD--CSNQKL 524
Query: 327 SQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNG 386
++I + +P T L +N E + + + K +K++ +
Sbjct: 525 NKIPEH---IPQYT--------------AELRLNNNEFTVLEATGIFKKLPQLRKINFSN 567
Query: 387 NSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFS 446
N I D++ F G++ + L SN++ ++ +F L +L+ L L N+I + + F
Sbjct: 568 NKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFI 627
Query: 447 GLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNN 483
GL +++ L L N I ++ G FD++ +L L L N
Sbjct: 628 GLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLAN 664
Score = 83.6 bits (205), Expect = 7e-16
Identities = 60/236 (25%), Positives = 106/236 (44%), Gaps = 34/236 (14%)
Query: 342 CPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFE 401
CPA C C + V+C+ K + + +P+ + ++ + N+IK + F+ ++
Sbjct: 273 CPAACTCSNN------IVDCRGKGLTEIPTNLPETIT--EIRLEQNTIKVIPPGAFSPYK 324
Query: 402 GLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 461
L + L +NQI+ + D F L +L L L GN+I L +F GL +LQ L L N I
Sbjct: 325 KLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKI 384
Query: 462 KEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQ 521
+ F + NL LL L +N L+++ G L+
Sbjct: 385 NCLRVDAFQDLHNLNLLSLYDNKLQTI------------------------AKGTFSPLR 420
Query: 522 SLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNE 577
++ + L NP+ C C L L ++ ++ I +C +P + AN + +K++
Sbjct: 421 AIQTMHLAQNPFICDCHLKWLADYLH--TNPIETSGARCTSPRRLANKRIGQIKSK 474
Score = 82.8 bits (203), Expect = 1e-15
Identities = 61/208 (29%), Positives = 100/208 (48%), Gaps = 35/208 (16%)
Query: 318 GKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPL 377
G + + +L +++ +V P CPA C C G +V+C ++S+ IP+
Sbjct: 5 GWQMLSLSLGLVLAILNKVAPQA-CPAQCSCS------GSTVDCHGLALRSVPRNIPR-- 55
Query: 378 NAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQI 437
N ++L +NGN+I + +DF L +L L N+I+ I+ F +L L RL LN N +
Sbjct: 56 NTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHL 115
Query: 438 ERLYPEI-------------------------FSGLHNLQYLYLEYNLIKEISAGTFDSM 472
+ L+PE+ F G +++ L L+YN I I G F ++
Sbjct: 116 Q-LFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRAL 174
Query: 473 PNLQLLYLNNNLLKSLPVYIFSGAPLAR 500
+L++L LNNN + L V F+ P R
Sbjct: 175 RDLEVLTLNNNNITRLSVASFNHMPKLR 202
Score = 67.8 bits (164), Expect = 4e-11
Identities = 43/148 (29%), Positives = 75/148 (50%), Gaps = 9/148 (6%)
Query: 338 PLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDF 397
PL+ CP C C L V C K ++ + + IP+ + +L+++GN V +
Sbjct: 723 PLSRCPTECTC------LDTVVRCSNKGLKVLPKGIPRDVT--ELYLDGNQFTLVP-KEL 773
Query: 398 TDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLE 457
++++ L L+ L +N+I+ + F N+T L L L+ N++ + P F GL +L+ L L
Sbjct: 774 SNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLH 833
Query: 458 YNLIKEISAGTFDSMPNLQLLYLNNNLL 485
N I + G F+ + L L + N L
Sbjct: 834 GNDISVVPEGAFNDLSALSHLAIGANPL 861
Score = 64.3 bits (155), Expect = 4e-10
Identities = 85/401 (21%), Positives = 151/401 (37%), Gaps = 60/401 (14%)
Query: 41 VNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEG 100
V+C + + + P ++ LN N F + F ++ NNK+ +IE
Sbjct: 517 VDCSNQKLNKIPEHIPQYTAELRLN-NNEFTVLEATGIFKKLPQLRKINFSNNKITDIEE 575
Query: 101 GAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVL 160
GAF G S + ++ L +N L+ ++ F G+E+L+ L N I + +F L +++L
Sbjct: 576 GAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLL 635
Query: 161 ILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCD 220
L DN I+ + G + + + L L NP+NC+C
Sbjct: 636 SLYDNQITTVAP------------------------GAFDTLHSLSTLNLLANPFNCNCY 671
Query: 221 LLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQL 280
L L WL I G C+ P L +++ Q+ D L
Sbjct: 672 LAWLGEWLRKK--RIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPT 729
Query: 281 ENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISG---IVAGKALSN-RNLSQIVSYQTRV 336
E + L L P+ + G + K LSN ++L+ I R+
Sbjct: 730 ECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRI 789
Query: 337 PPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSD 396
L+ ++ +M++L+ L ++ N ++ +
Sbjct: 790 STLS----------------------NQSFSNMTQLL-------TLILSYNRLRCIPPRT 820
Query: 397 FTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQI 437
F + L LL L N I+V+ F++L+ L L + N +
Sbjct: 821 FDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPL 861
Score = 57.0 bits (136), Expect = 7e-08
Identities = 33/109 (30%), Positives = 53/109 (48%)
Query: 57 PWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNN 116
P+ ++ NN ++ L P+ F SL L NK+ + F GL +L+ L LN
Sbjct: 322 PYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNA 381
Query: 117 NELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDN 165
N++ LR D F + NL L N ++ I +G F+ L ++ + L N
Sbjct: 382 NKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN 430
Score = 44.7 bits (104), Expect = 4e-04
Identities = 44/168 (26%), Positives = 70/168 (41%), Gaps = 31/168 (18%)
Query: 109 LKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLIS 168
L + L+NN + L +F + L L YN ++ I F+ L L++L L+ N IS
Sbjct: 779 LTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDIS 838
Query: 169 FLPDNIFR-FASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAW 227
+P+ F ++L+HL I NP C C++ L W
Sbjct: 839 VVPEGAFNDLSALSHLAIGA-------------------------NPLYCDCNMQWLSDW 873
Query: 228 LENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRIL 275
+++ Y G A C P ++ +LL T ++ G DV IL
Sbjct: 874 VKS-EYK-EPGIARCAGPGEMADKLLLTTPSKKFTCQG---PVDVNIL 916
Score = 34.7 bits (78), Expect = 0.38
Identities = 21/69 (30%), Positives = 31/69 (44%)
Query: 59 SNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNE 118
+ Y L+ N + + F +L L N++ IE GAF L L+ L LNNN
Sbjct: 127 AKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNN 186
Query: 119 LKILRADTF 127
+ L +F
Sbjct: 187 ITRLSVASF 195
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 92.4 bits (228), Expect = 2e-18
Identities = 68/218 (31%), Positives = 107/218 (49%), Gaps = 23/218 (10%)
Query: 339 LTPCPAPCFC--------KTHPSDLGLS---------VNCQEKNIQSMSELIPKPLNA-- 379
L CP C C + SDLGLS + + ++ ++S+L+P PL +
Sbjct: 31 LRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR 90
Query: 380 --KKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQI 437
++L + GN++ + FT L +L L +NQ+ + + NL +L+ L L+ N I
Sbjct: 91 FLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHI 150
Query: 438 ERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSG-A 496
+ P FSGLH+L++L+L+ N + EI F S+ LQ + L N + +P Y F +
Sbjct: 151 SYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLS 210
Query: 497 PLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWD 534
L L+L NN+ L D L SL +DL N D
Sbjct: 211 SLVVLHLHNNRIHSLG-KKCFDGLHSLETLDLNYNNLD 247
Score = 89.0 bits (219), Expect = 2e-17
Identities = 110/432 (25%), Positives = 186/432 (43%), Gaps = 48/432 (11%)
Query: 63 HLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKIL 122
+L+ N ++ L PN + L L N L I GAF GL +LK L L NN+L+ +
Sbjct: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129
Query: 123 RADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FASLT 181
+ + +L+ L+ D N I Y+ F+ LH L+ L L+DN ++ +P FR ++L
Sbjct: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
Query: 182 HLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAI 241
+ + N+I +P ++ +V L L +N + ++ + G
Sbjct: 190 AMTLALNKIHHIPDY-AFGNLSSLVVLHLHNNR-------------IHSLGKKCFDGLHS 235
Query: 242 CETPSDLYGRL----LKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLH 297
ET Y L L +G S+ ++R +P E + G+ + ++H
Sbjct: 236 LETLDLNYNNLDEFPTAIRTLSNLKELGFHSN-NIRSIP----EKAFV---GNPSLITIH 287
Query: 298 RLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGL 357
P + S + + L+ SQI T P L T ++L
Sbjct: 288 -FYDNPIQFVGRSAFQHLPELRTLTLNGASQI----TEFPDL----------TGTANLE- 331
Query: 358 SVNCQEKNIQSMSELIPKPL-NAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVI 416
S+ I S+ + + L N + L ++ N ++ D+ F+ + L + L N+I I
Sbjct: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLE--DLPSFSVCQKLQKIDLRHNEIYEI 389
Query: 417 KGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQ 476
K D F L +LR L L N+I ++P FS L +L L L NL+ + +L+
Sbjct: 390 KVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLK 449
Query: 477 LLYLNNNLLKSL 488
L N+ L+SL
Sbjct: 450 L--TGNHALQSL 459
Score = 66.2 bits (160), Expect = 1e-10
Identities = 56/207 (27%), Positives = 91/207 (43%), Gaps = 6/207 (2%)
Query: 325 NLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHV 384
NLS +V + CF H + +++ N+ I N K+L
Sbjct: 208 NLSSLVVLHLHNNRIHSLGKKCFDGLHSLE---TLDLNYNNLDEFPTAIRTLSNLKELGF 264
Query: 385 NGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEI 444
+ N+I+ + F L +H N I + F +L LR L LNG +P++
Sbjct: 265 HSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDL 324
Query: 445 FSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLR 504
+G NL+ L L I + + +PNLQ+L L+ NLL+ LP + L +++LR
Sbjct: 325 -TGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVC-QKLQKIDLR 382
Query: 505 NNKFMYLPVSGVLDQLQSLTQIDLEGN 531
+N+ + V QL SL ++L N
Sbjct: 383 HNEIYEIKVD-TFQQLLSLRSLNLAWN 408
Score = 47.4 bits (111), Expect = 6e-05
Identities = 38/135 (28%), Positives = 61/135 (45%), Gaps = 2/135 (1%)
Query: 59 SNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNE 118
SN L F +N + + F+ +++H +N +Q + AF L L+ L LN
Sbjct: 257 SNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGAS 316
Query: 119 LKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFA 178
+I G NLE L I + + N+L L+VL L+ NL+ LP +
Sbjct: 317 -QITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP-SFSVCQ 374
Query: 179 SLTHLDIRGNRIQKL 193
L +D+R N I ++
Sbjct: 375 KLQKIDLRHNEIYEI 389
Score = 47.0 bits (110), Expect = 7e-05
Identities = 100/440 (22%), Positives = 161/440 (36%), Gaps = 78/440 (17%)
Query: 104 LGLSALKQ--------LHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLH 155
LGLS L L L+ N + L + + LE L+ N + YI +GAF L+
Sbjct: 55 LGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLY 114
Query: 156 KLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDN-- 213
LKVL+ ++ N+++ +P L+++ + L+L+ N
Sbjct: 115 SLKVLM-----------------------LQNNQLRHVP-TEALQNLRSLQSLRLDANHI 150
Query: 214 ---PWNCSCDLLPLK-AWLENMPYNIYIGEAICETP-------SDLYGRLLKETNKQELC 262
P +C L L+ WL++ A+ E P S L L +
Sbjct: 151 SYVPPSCFSGLHSLRHLWLDD--------NALTEIPVQAFRSLSALQAMTLALNKIHHIP 202
Query: 263 PMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALS 322
G+ + +L L N G LH L T N + + + LS
Sbjct: 203 DYAFGNLSSLVVL---HLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAI--RTLS 257
Query: 323 NRNLSQIVSYQTR-VPPLTPCPAPCFCKTHPSD-----LGLSV-----NCQEKNIQSMSE 371
N S R +P P H D +G S + + S+
Sbjct: 258 NLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQ 317
Query: 372 LIPKP-----LNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTN 426
+ P N + L + G I + + L +L L N + + F
Sbjct: 318 ITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQK 375
Query: 427 LRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLK 486
L+++ L N+I + + F L +L+ L L +N I I F ++P+L L L++NLL
Sbjct: 376 LQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLS 435
Query: 487 SLPVYIFSGAPLARLNLRNN 506
S P+ G L L L N
Sbjct: 436 SFPITGLHG--LTHLKLTGN 453
>gi|38202222 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 91.7 bits (226), Expect = 3e-18
Identities = 71/249 (28%), Positives = 121/249 (48%), Gaps = 34/249 (13%)
Query: 359 VNCQEKNIQSMS-ELIPKPLNAKKLHVNGNSIKDVDVSD--FTDFEGLDLLHLG------ 409
++ QE NI++++ + + K ++LH++ NS+ V + + F D L LL L
Sbjct: 109 LHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLST 168
Query: 410 ---------------SNQITVIKGDVFHNLTNLRRLYLNGNQIER--LYPEIFSGLHNLQ 452
N+I+ I LT+L+RL L+GN + L ++F L NL
Sbjct: 169 IPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLT 228
Query: 453 YLYLEYNLIKEISAGTFDSMP--NLQLLYLNNNLLKSLPVYIFSGA-PLARLNLRNNKFM 509
E +L++ ++P NL+ LYL +N + +P FS L RL++ NN
Sbjct: 229 ----ELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLS 284
Query: 510 YLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANI 569
LP G+ D L ++TQ+ L NPW C C + ++ W++ L + V+ L C+ P + +
Sbjct: 285 NLP-QGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGM 343
Query: 570 ELKSLKNEI 578
+K L E+
Sbjct: 344 AIKDLNAEL 352
Score = 79.0 bits (193), Expect = 2e-14
Identities = 49/175 (28%), Positives = 85/175 (48%), Gaps = 6/175 (3%)
Query: 88 LHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKI--LRADTFLGIENLEYLQADYNLIKY 145
L L +N++ I + GL++LK+L L+ N L L F + NL L N +
Sbjct: 180 LRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTA 239
Query: 146 IERGAFNKLHKLKVLILNDNLISFLPDNIFRFA-SLTHLDIRGNRIQKLPYIGVLEHIGR 204
L+ L L DN I+ +P N F + L LD+ N + LP G+ + +
Sbjct: 240 APVNLPGT--NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQ-GIFDDLDN 296
Query: 205 VVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQ 259
+ +L L +NPW C C + ++ WL+++P + + +C+ P + G +K+ N +
Sbjct: 297 ITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAE 351
Score = 44.3 bits (103), Expect = 5e-04
Identities = 42/148 (28%), Positives = 68/148 (45%), Gaps = 10/148 (6%)
Query: 64 LNFQNNFLNIL-YPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKIL 122
L QNN +N P+ N ++L +N L +K+LHL N ++ +
Sbjct: 63 LYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNL---PKYVKELHLQENNIRTI 119
Query: 123 RADTFLGIENLEYLQADYNLIK--YIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASL 180
D+ I LE L D N + IE GAF + L++L L+ N +S +P + R ++
Sbjct: 120 TYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPR--TI 177
Query: 181 THLDIRGNRIQKL--PYIGVLEHIGRVV 206
L + NRI + P + L + R+V
Sbjct: 178 EELRLDDNRISTISSPSLQGLTSLKRLV 205
Score = 40.4 bits (93), Expect = 0.007
Identities = 22/61 (36%), Positives = 29/61 (47%)
Query: 57 PWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNN 116
P +N L Q+N +N + PN F L + NN L N+ G F L + QL L N
Sbjct: 245 PGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRN 304
Query: 117 N 117
N
Sbjct: 305 N 305
>gi|7019383 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 91.7 bits (226), Expect = 3e-18
Identities = 71/249 (28%), Positives = 121/249 (48%), Gaps = 34/249 (13%)
Query: 359 VNCQEKNIQSMS-ELIPKPLNAKKLHVNGNSIKDVDVSD--FTDFEGLDLLHLG------ 409
++ QE NI++++ + + K ++LH++ NS+ V + + F D L LL L
Sbjct: 109 LHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLST 168
Query: 410 ---------------SNQITVIKGDVFHNLTNLRRLYLNGNQIER--LYPEIFSGLHNLQ 452
N+I+ I LT+L+RL L+GN + L ++F L NL
Sbjct: 169 IPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLT 228
Query: 453 YLYLEYNLIKEISAGTFDSMP--NLQLLYLNNNLLKSLPVYIFSGA-PLARLNLRNNKFM 509
E +L++ ++P NL+ LYL +N + +P FS L RL++ NN
Sbjct: 229 ----ELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLS 284
Query: 510 YLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANI 569
LP G+ D L ++TQ+ L NPW C C + ++ W++ L + V+ L C+ P + +
Sbjct: 285 NLP-QGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGM 343
Query: 570 ELKSLKNEI 578
+K L E+
Sbjct: 344 AIKDLNAEL 352
Score = 79.0 bits (193), Expect = 2e-14
Identities = 49/175 (28%), Positives = 85/175 (48%), Gaps = 6/175 (3%)
Query: 88 LHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKI--LRADTFLGIENLEYLQADYNLIKY 145
L L +N++ I + GL++LK+L L+ N L L F + NL L N +
Sbjct: 180 LRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTA 239
Query: 146 IERGAFNKLHKLKVLILNDNLISFLPDNIFRFA-SLTHLDIRGNRIQKLPYIGVLEHIGR 204
L+ L L DN I+ +P N F + L LD+ N + LP G+ + +
Sbjct: 240 APVNLPGT--NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQ-GIFDDLDN 296
Query: 205 VVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQ 259
+ +L L +NPW C C + ++ WL+++P + + +C+ P + G +K+ N +
Sbjct: 297 ITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAE 351
Score = 44.3 bits (103), Expect = 5e-04
Identities = 42/148 (28%), Positives = 68/148 (45%), Gaps = 10/148 (6%)
Query: 64 LNFQNNFLNIL-YPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKIL 122
L QNN +N P+ N ++L +N L +K+LHL N ++ +
Sbjct: 63 LYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNL---PKYVKELHLQENNIRTI 119
Query: 123 RADTFLGIENLEYLQADYNLIK--YIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASL 180
D+ I LE L D N + IE GAF + L++L L+ N +S +P + R ++
Sbjct: 120 TYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPR--TI 177
Query: 181 THLDIRGNRIQKL--PYIGVLEHIGRVV 206
L + NRI + P + L + R+V
Sbjct: 178 EELRLDDNRISTISSPSLQGLTSLKRLV 205
Score = 40.4 bits (93), Expect = 0.007
Identities = 22/61 (36%), Positives = 29/61 (47%)
Query: 57 PWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNN 116
P +N L Q+N +N + PN F L + NN L N+ G F L + QL L N
Sbjct: 245 PGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRN 304
Query: 117 N 117
N
Sbjct: 305 N 305
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,048,311
Number of Sequences: 37866
Number of extensions: 1603254
Number of successful extensions: 8445
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 227
Number of HSP's successfully gapped in prelim test: 70
Number of HSP's that attempted gapping in prelim test: 4790
Number of HSP's gapped (non-prelim): 1712
length of query: 837
length of database: 18,247,518
effective HSP length: 111
effective length of query: 726
effective length of database: 14,044,392
effective search space: 10196228592
effective search space used: 10196228592
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.