BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|26638650 large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform b [Homo sapiens] (1178 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|26638650 large conductance calcium-activated potassium channe... 2373 0.0 gi|238624132 large conductance calcium-activated potassium chann... 2353 0.0 gi|62388890 large conductance calcium-activated potassium channe... 2352 0.0 gi|238624130 large conductance calcium-activated potassium chann... 2276 0.0 gi|157074214 potassium channel, subfamily U, member 1 [Homo sapi... 890 0.0 gi|41349443 potassium channel, subfamily T, member 2 [Homo sapiens] 124 4e-28 gi|240255505 potassium channel, subfamily T, member 1 [Homo sapi... 118 4e-26 gi|27436974 potassium voltage-gated channel, Shab-related subfam... 65 5e-10 gi|20070166 potassium voltage-gated channel, subfamily F, member... 65 5e-10 gi|4826784 potassium voltage-gated channel, Shab-related subfami... 63 2e-09 gi|18375613 dachshund homolog 1 isoform b [Homo sapiens] 62 4e-09 gi|18375611 dachshund homolog 1 isoform a [Homo sapiens] 62 4e-09 gi|18375609 dachshund homolog 1 isoform c [Homo sapiens] 62 4e-09 gi|88758576 Shaw-related voltage-gated potassium channel protein... 59 2e-08 gi|24497462 Shaw-related voltage-gated potassium channel protein... 59 2e-08 gi|24497464 Shaw-related voltage-gated potassium channel protein... 59 2e-08 gi|27436996 potassium voltage-gated channel, subfamily G, member... 59 4e-08 gi|27436984 potassium voltage-gated channel, Shal-related subfam... 58 6e-08 gi|27436986 potassium voltage-gated channel, Shal-related subfam... 58 6e-08 gi|9789987 potassium voltage-gated channel, Shal-related subfami... 56 2e-07 gi|21217561 Shaw-related voltage-gated potassium channel protein... 56 2e-07 gi|21217563 Shaw-related voltage-gated potassium channel protein... 56 2e-07 gi|24497458 Shaw-related voltage-gated potassium channel protein... 56 2e-07 gi|27436988 potassium voltage-gated channel, subfamily G, member... 55 3e-07 gi|24497460 Shaw-related voltage-gated potassium channel protein... 55 5e-07 gi|4826786 Shaw-related voltage-gated potassium channel protein ... 54 1e-06 gi|163792201 Shaw-related voltage-gated potassium channel protei... 54 1e-06 gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens] 54 1e-06 gi|27436981 potassium voltage-gated channel, Shal-related subfam... 53 2e-06 gi|45383011 potassium voltage-gated channel, delayed-rectifier, ... 52 3e-06 >gi|26638650 large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform b [Homo sapiens] Length = 1178 Score = 2373 bits (6149), Expect = 0.0 Identities = 1178/1178 (100%), Positives = 1178/1178 (100%) Query: 1 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS 60 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS Sbjct: 1 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS 60 Query: 61 VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH 120 VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH Sbjct: 61 VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH 120 Query: 121 CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL 180 CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL Sbjct: 121 CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL 180 Query: 181 VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL 240 VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL Sbjct: 181 VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL 240 Query: 241 WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL 300 WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL Sbjct: 241 WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL 300 Query: 301 VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA 360 VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA Sbjct: 301 VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA 360 Query: 361 KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES 420 KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES Sbjct: 361 KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES 420 Query: 421 VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK 480 VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK Sbjct: 421 VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK 480 Query: 481 IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW 540 IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW Sbjct: 481 IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW 540 Query: 541 NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE 600 NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE Sbjct: 541 NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE 600 Query: 601 MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG 660 MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG Sbjct: 601 MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG 660 Query: 661 FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNS 720 FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNS Sbjct: 661 FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNS 720 Query: 721 PNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVL 780 PNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVL Sbjct: 721 PNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVL 780 Query: 781 SGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPK 840 SGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPK Sbjct: 781 SGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPK 840 Query: 841 VSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDS 900 VSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDS Sbjct: 841 VSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDS 900 Query: 901 IGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDD 960 IGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDD Sbjct: 901 IGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDD 960 Query: 961 DDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAE 1020 DDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAE Sbjct: 961 DDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAE 1020 Query: 1021 ENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIY 1080 ENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIY Sbjct: 1021 ENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIY 1080 Query: 1081 RLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQS 1140 RLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQS Sbjct: 1081 RLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQS 1140 Query: 1141 SSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL 1178 SSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL Sbjct: 1141 SSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL 1178 >gi|238624132 large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform d [Homo sapiens] Length = 1219 Score = 2353 bits (6097), Expect = 0.0 Identities = 1178/1219 (96%), Positives = 1178/1219 (96%), Gaps = 41/1219 (3%) Query: 1 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS 60 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS Sbjct: 1 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS 60 Query: 61 VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH 120 VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH Sbjct: 61 VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH 120 Query: 121 CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL 180 CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL Sbjct: 121 CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL 180 Query: 181 VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL 240 VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL Sbjct: 181 VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL 240 Query: 241 WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL 300 WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL Sbjct: 241 WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL 300 Query: 301 VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA 360 VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA Sbjct: 301 VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA 360 Query: 361 KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES 420 KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES Sbjct: 361 KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES 420 Query: 421 VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK 480 VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK Sbjct: 421 VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK 480 Query: 481 IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW 540 IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW Sbjct: 481 IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW 540 Query: 541 NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE 600 NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE Sbjct: 541 NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE 600 Query: 601 MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG 660 MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG Sbjct: 601 MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG 660 Query: 661 FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNS 720 FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNS Sbjct: 661 FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNS 720 Query: 721 PNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVIL---------- 770 PNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVIL Sbjct: 721 PNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILVTGWMPYLGP 780 Query: 771 -------------------------------TRSEAAMTVLSGHVVVCIFGDVSSALIGL 799 TRSEAAMTVLSGHVVVCIFGDVSSALIGL Sbjct: 781 RVLMTCLDIGVVCMPTDIQSTSPASIKKFKETRSEAAMTVLSGHVVVCIFGDVSSALIGL 840 Query: 800 RNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNI 859 RNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNI Sbjct: 841 RNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNI 900 Query: 860 NLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRS 919 NLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRS Sbjct: 901 NLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRS 960 Query: 920 SPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTA 979 SPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTA Sbjct: 961 SPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTA 1020 Query: 980 FAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDR 1039 FAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDR Sbjct: 1021 FAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDR 1080 Query: 1040 CRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVI 1099 CRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVI Sbjct: 1081 CRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVI 1140 Query: 1100 TNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQN 1159 TNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQN Sbjct: 1141 TNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQN 1200 Query: 1160 RPKSRESRDKQKYVQEERL 1178 RPKSRESRDKQKYVQEERL Sbjct: 1201 RPKSRESRDKQKYVQEERL 1219 >gi|62388890 large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform a [Homo sapiens] Length = 1182 Score = 2352 bits (6094), Expect = 0.0 Identities = 1170/1174 (99%), Positives = 1170/1174 (99%), Gaps = 4/1174 (0%) Query: 1 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS 60 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS Sbjct: 1 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS 60 Query: 61 VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH 120 VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH Sbjct: 61 VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH 120 Query: 121 CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL 180 CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL Sbjct: 121 CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL 180 Query: 181 VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL 240 VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL Sbjct: 181 VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL 240 Query: 241 WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL 300 WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL Sbjct: 241 WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL 300 Query: 301 VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA 360 VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA Sbjct: 301 VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA 360 Query: 361 KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES 420 KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES Sbjct: 361 KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES 420 Query: 421 VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK 480 VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK Sbjct: 421 VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK 480 Query: 481 IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW 540 IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW Sbjct: 481 IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW 540 Query: 541 NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE 600 NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE Sbjct: 541 NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE 600 Query: 601 MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRES----RILINPGNHLKIQE 656 MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRES RILINPGNHLKIQE Sbjct: 601 MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRSRKRILINPGNHLKIQE 660 Query: 657 GTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGG 716 GTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGG Sbjct: 661 GTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGG 720 Query: 717 MRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAA 776 MRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAA Sbjct: 721 MRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAA 780 Query: 777 MTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLH 836 MTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLH Sbjct: 781 MTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLH 840 Query: 837 NFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQ 896 NFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQ Sbjct: 841 NFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQ 900 Query: 897 FDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFL 956 FDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFL Sbjct: 901 FDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFL 960 Query: 957 DQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEA 1016 DQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEA Sbjct: 961 DQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEA 1020 Query: 1017 LIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLC 1076 LIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLC Sbjct: 1021 LIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLC 1080 Query: 1077 FGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSH 1136 FGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSH Sbjct: 1081 FGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSH 1140 Query: 1137 SSQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQ 1170 SSQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQ Sbjct: 1141 SSQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQ 1174 >gi|238624130 large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform c [Homo sapiens] Length = 1236 Score = 2276 bits (5897), Expect = 0.0 Identities = 1155/1241 (93%), Positives = 1162/1241 (93%), Gaps = 68/1241 (5%) Query: 1 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS 60 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS Sbjct: 1 MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS 60 Query: 61 VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH 120 VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH Sbjct: 61 VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH 120 Query: 121 CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL 180 CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL Sbjct: 121 CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL 180 Query: 181 VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL 240 VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL Sbjct: 181 VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL 240 Query: 241 WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL 300 WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL Sbjct: 241 WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL 300 Query: 301 VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA 360 VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA Sbjct: 301 VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA 360 Query: 361 KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES 420 KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES Sbjct: 361 KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES 420 Query: 421 VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK 480 VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK Sbjct: 421 VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK 480 Query: 481 IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW 540 IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW Sbjct: 481 IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW 540 Query: 541 NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE 600 NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE Sbjct: 541 NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE 600 Query: 601 MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG 660 MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG Sbjct: 601 MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG 660 Query: 661 FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQR------- 713 FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKR P K+ +R Sbjct: 661 FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKR-----PKMSIYKRMRRACCFDCG 715 Query: 714 ---------NGGMRNSPNT------------------------------SPKL------M 728 +G +R + +T SPK M Sbjct: 716 RSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGM 775 Query: 729 RHDP-----------LLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAM 777 R+ P LLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAM Sbjct: 776 RNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAM 835 Query: 778 TVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHN 837 TVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHN Sbjct: 836 TVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHN 895 Query: 838 FPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQF 897 FPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQF Sbjct: 896 FPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQF 955 Query: 898 DDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLD 957 DDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLD Sbjct: 956 DDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLD 1015 Query: 958 QDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEAL 1017 QDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEAL Sbjct: 1016 QDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEAL 1075 Query: 1018 IAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCF 1077 IAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCF Sbjct: 1076 IAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCF 1135 Query: 1078 GIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHS 1137 GIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHS Sbjct: 1136 GIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHS 1195 Query: 1138 SQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL 1178 SQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL Sbjct: 1196 SQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL 1236 >gi|157074214 potassium channel, subfamily U, member 1 [Homo sapiens] Length = 1149 Score = 890 bits (2300), Expect = 0.0 Identities = 477/1085 (43%), Positives = 671/1085 (61%), Gaps = 63/1085 (5%) Query: 89 AFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQ-----ADGTLK 143 AF+ SS VTFF GL I+L++R + W ++ + +I G+ GT+ Sbjct: 26 AFILSSFVTFFSGLIILLIFRLI---W--------RSVKKWQIIKGTGIILELFTSGTIA 74 Query: 144 PVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPI 203 + + + +D +++SAQT G+VLV+LVF LSIG+L+IYFI+S++P+ Sbjct: 75 ------RSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIYFINSADPV 128 Query: 204 ESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVY 263 SC + Y+D T+ ID+ FN FF YFGLRF+AA+DK+ FWLE+NS+VD FT+PP F+S Y Sbjct: 129 GSCSS-YEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYY 187 Query: 264 LNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVEN 323 L +WLGLRFLRALRL++ +ILQ L +KTSNS+K LLSI +STW TAAGFIHLVEN Sbjct: 188 LKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAGFIHLVEN 247 Query: 324 SGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASY 383 SGDPW +N+Q ++Y+E +YL+M T STVG+GDV AKT+LGR F++FF LG L +FA+Y Sbjct: 248 SGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANY 307 Query: 384 VPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFL 443 +PE++EL N++KY SY A+ G+K IVVCG+IT++SV+ FL++FL ++N EIVFL Sbjct: 308 IPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEINTEIVFL 367 Query: 444 HNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDA 503 P+LELE +FK + F GS + DL RV +ESA+ACLI+AN C+D AED Sbjct: 368 GETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCSDSHAEDI 427 Query: 504 SNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSC 563 SNIMRV+SIKNY RII Q+LQ HNK +L IPSWNW GD+ IC AELKLGFIAQ C Sbjct: 428 SNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKLGFIAQGC 487 Query: 564 LAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCF 623 L GL T L +LF ++ + + TW+K++L + N++ T+ LS F G+SFP V LCF Sbjct: 488 LVPGLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFPEVARLCF 547 Query: 624 VKLKLLMIAIEYKSANRES--RILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACH 681 +K+ LL+IAIEYKS + +++NP ++I++ TLGFFIA K+V+RA FYC CH Sbjct: 548 LKMHLLLIAIEYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRALFYCSVCH 607 Query: 682 DDITDPKRIKKCGCK---RLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGN 738 DD+ P+ I CGCK R PS KK + R S SP P + Sbjct: 608 DDVFIPELITNCGCKSRSRQHITVPSVKRMKKCLKGISSRISGQDSP------PRVSAST 661 Query: 739 DQIDN---------MDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIF 789 I N ++ + + DS+GMFHWC P ++KV L R+ + H+V C+F Sbjct: 662 SSISNFTTRTLQHDVEQDSDQLDSSGMFHWCKPTSLDKVTLKRTGKSKYKFRNHIVACVF 721 Query: 790 GDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPL 849 GD SA +GLRN VMPLRASN+ ELK IVF+GS++YL+REW L NFP++ ILPG L Sbjct: 722 GDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILPGCAL 781 Query: 850 SRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQ 909 DL A NI C MC +LS + +L D E I+A+L I S+Q D S + S+ Sbjct: 782 YSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVSE 841 Query: 910 GFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQ---DDDDDPDT 966 PG + S +PI+TEL N +N+ F++Q + +T Sbjct: 842 --ETPGYTNGHNEKSNCR------------KVPILTELKNPSNIHFIEQLGGLEGSLQET 887 Query: 967 ELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRG 1026 L+L+ F+ GT F+ S LDSL++ ++N ++L L++ LVTGG + +LE + ++ Sbjct: 888 NLHLSTAFSTGTVFSGSFLDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGV 947 Query: 1027 GYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAH 1086 S L+ R+RC++ L+L + +D+ +G LFC +L + +LC G+YR+ D Sbjct: 948 ADSCTSLLSGRNRCKLGLLSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEE 1007 Query: 1087 LSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLS-HSSHSSQSSSKKS 1145 P KR+VIT P EF+L+P+DL+FC + F + S S+ + + ++ Sbjct: 1008 ELNPE--NKRFVITRPANEFKLLPSDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKASQT 1065 Query: 1146 SSVHS 1150 + HS Sbjct: 1066 TETHS 1070 >gi|41349443 potassium channel, subfamily T, member 2 [Homo sapiens] Length = 1135 Score = 124 bits (312), Expect = 4e-28 Identities = 128/489 (26%), Positives = 210/489 (42%), Gaps = 61/489 (12%) Query: 215 LQIDMAFNVFFLLYFGLRFIAANDKLW-------FWLEVNSVVDFF------TVPPVFVS 261 LQ+ +A F L +++ +W F LE+ + V F ++ +FV Sbjct: 107 LQVSVALISLFETIL-LGYLSYKGNIWEQILRIPFILEIINAVPFIISIFWPSLRNLFVP 165 Query: 262 VYLNRSWLGLRFLRAL-----RLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAG 316 V+LN WL L + R IQ ++ F +L L++ L I T + G Sbjct: 166 VFLN-CWLAKHALENMINDLHRAIQRTQSAMFNQVLI------LISTLLCLIFTCI--CG 216 Query: 317 FIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGG 376 HL E G + L ++ +Y +VT STVG+GDV +T +LF+V I Sbjct: 217 IQHL-ERIG---------KKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVA 266 Query: 377 LAMFASYVPEIIELIGNRKKYGGSYSA--VSGRKHIVVC-GHITLESVSNFLKDFL-HKD 432 L + ++ L R+K GG+YS KH+V+C + ++ + +FL +F H Sbjct: 267 LVVLPIQFEQLAYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPR 326 Query: 433 RDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILAN 492 D V I+ + + +V + QGS L DL R K++ A+AC IL++ Sbjct: 327 LQDYYVVILCPTEMDVQVRRVLQIPMWSQRVIYLQGSALKDQDLLRAKMDDAEACFILSS 386 Query: 493 KYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLA 552 + D + D I+R ++K++ P + Q+L+ NK H+ K D +C Sbjct: 387 RCEVDRTSSDHQTILRAWAVKDFAPNCPLYVQILKPENKFHI--------KFADHVVCEE 438 Query: 553 ELKLGFIAQSCLAQGLSTMLANLF--SMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSA- 609 E K +A +C+ ST++ L S + + WQK Y NE+Y L + Sbjct: 439 EFKYAMLALNCICPATSTLITLLVHTSRGQEGQQSPEQWQKMYGRCSGNEVYHIVLEEST 498 Query: 610 ----FVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIAS 665 + G SF K + +I + + IL+NPG + + F+I + Sbjct: 499 FFAEYEGKSFTYASFHAHKKFGVCLIGVRRED---NKNILLNPGPRYIMNSTDICFYI-N 554 Query: 666 DAKEVKRAF 674 KE AF Sbjct: 555 ITKEENSAF 563 Score = 37.0 bits (84), Expect = 0.11 Identities = 21/89 (23%), Positives = 43/89 (48%), Gaps = 16/89 (17%) Query: 940 NIPIITELVNDTNVQFLD----------------QDDDDDPDTELYLTQPFACGTAFAVS 983 ++ IITEL + N++F+ ++ + + PFA G F++S Sbjct: 832 SLSIITELTHPANMRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVFSIS 891 Query: 984 VLDSLMSATYFNDNILTLIRTLVTGGATP 1012 +LD+L+ ++ D ++++ R L+ TP Sbjct: 892 MLDTLLYQSFVKDYMISITRLLLGLDTTP 920 >gi|240255505 potassium channel, subfamily T, member 1 [Homo sapiens] Length = 1235 Score = 118 bits (295), Expect = 4e-26 Identities = 126/489 (25%), Positives = 210/489 (42%), Gaps = 53/489 (10%) Query: 213 FTLQIDMAFNVFFLLYFGLRFIAANDKLW-------FWLEVNSVVDFFTV---PPV---F 259 + +Q+ +A + FL L +++ +W F LE+ + + F PP+ F Sbjct: 177 WAIQVIVAI-ISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLF 235 Query: 260 VSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIH 319 + V+LN WL L + IL+ + + I LL + + G H Sbjct: 236 IPVFLN-CWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTG---TCGIQH 291 Query: 320 LVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAM 379 L E +G+ N LT + Y +VT STVGYGDV K +L +V I L + Sbjct: 292 L-ERAGE------NLSLLTSF---YFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVV 341 Query: 380 FASYVPEIIELIGNRKKYGGSYSA--VSGRKHIVVC-GHITLESVSNFLKDFL-HKDRDD 435 E++ L R+K GG+YS KH+V+C + ++ + +FL +F H D Sbjct: 342 LPLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQD 401 Query: 436 VNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYC 495 V I+ + + +V + QGS L DL R K+++ +AC IL+++ Sbjct: 402 YYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNE 461 Query: 496 ADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELK 555 D A D I+R ++K++ P + Q+L+ NK H+ K D +C E K Sbjct: 462 VDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHV--------KFADHVVCEEECK 513 Query: 556 LGFIAQSCLAQGLSTMLANLFSMRSFIKIEE--DTWQKYYLEGVSNEMYTEYLSSA---- 609 +A +C+ ST++ L + +E + WQ+ Y NE+Y + + Sbjct: 514 YAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFR 573 Query: 610 -FVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPG-NHLKIQEGTLGFFIASDA 667 + G SF K + +I ++ + IL+NPG H+ T F + Sbjct: 574 EYEGKSFTYAAFHAHKKYGVCLIGLKRED---NKSILLNPGPRHILAASDTC--FYINIT 628 Query: 668 KEVKRAFFY 676 KE AF + Sbjct: 629 KEENSAFIF 637 Score = 38.5 bits (88), Expect = 0.038 Identities = 47/217 (21%), Positives = 89/217 (41%), Gaps = 29/217 (13%) Query: 798 GLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAV 857 GL N ++PLRA EL IV + + E + FP V + G+ + L Sbjct: 813 GLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQC 872 Query: 858 NINLCDMCVILSANQN-NIDDTSLQDKECILASLNIKSM-QFDDSIGVLQANSQGFTPPG 915 I D V++ + ++ + D + I+ N+++M + S+ + Sbjct: 873 GIIYADNLVVVDKESTMSAEEDYMADAKTIV---NVQTMFRLFPSLSITT---------- 919 Query: 916 MDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFA 975 + + P N + S + ++ E N +N+ F+ PFA Sbjct: 920 -ELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFM-------------FRLPFA 965 Query: 976 CGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATP 1012 G F++S+LD+L+ ++ D ++T+ R L+ TP Sbjct: 966 AGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTP 1002 Score = 34.7 bits (78), Expect = 0.55 Identities = 25/73 (34%), Positives = 42/73 (57%), Gaps = 12/73 (16%) Query: 1092 QCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSI 1151 Q T YV+ NPP + L P+D+++ L++ D L+H + SSQ S+KSS H + Sbjct: 1174 QNTLSYVLINPPPDTRLEPSDIVY-LIRSD--------PLAHVASSSQ--SRKSSCSHKL 1222 Query: 1152 PSTANRQNRPKSR 1164 S+ N + R +++ Sbjct: 1223 -SSCNPETRDETQ 1234 >gi|27436974 potassium voltage-gated channel, Shab-related subfamily, member 2 [Homo sapiens] Length = 911 Score = 64.7 bits (156), Expect = 5e-10 Identities = 45/180 (25%), Positives = 85/180 (47%), Gaps = 20/180 (11%) Query: 224 FFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG-LRFLRALRLIQF 282 +F + + LRF+++ +K F+ +V+D + P +V+++L S L+F R++Q Sbjct: 243 WFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQI 302 Query: 283 SEILQFLNILKTSN--------------SIKLVNLLSIFISTWLTAAGFIHLVENSGDPW 328 I++ L ILK + S + LL +F++ + + + Sbjct: 303 FRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDA 362 Query: 329 ENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEII 388 F + A +W + TM+TVGYGD+Y KT LG++ + G+ + A +P I+ Sbjct: 363 TKFTSIPASFWWATI-----TMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIV 417 >gi|20070166 potassium voltage-gated channel, subfamily F, member 1 [Homo sapiens] Length = 494 Score = 64.7 bits (156), Expect = 5e-10 Identities = 65/258 (25%), Positives = 111/258 (43%), Gaps = 29/258 (11%) Query: 153 AAEVGWMTSVKD-WAGVMISAQTLTGRVLVVLVFALSIGALVIYF---IDSSNPIESCQN 208 AAE W K W + + RV+ VL F L + + V+ I +++ N Sbjct: 156 AAEGRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCMGTIPELQVLDAEGN 215 Query: 209 FYKDFTLQ-IDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRS 267 + TL+ ++ A +F L + LR ++ +KL F L ++VD + P +VS+ L Sbjct: 216 RVEHPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTH- 274 Query: 268 WLGLRFLRALRLIQFSEILQFLNILKT-----------------SNSIKLVNLLSIFIST 310 LG R + + Q + L+ + I + S K + LL ++++ Sbjct: 275 -LGARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAV 333 Query: 311 WLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMV 370 + + P F++ +W ++TM+TVGYGD+Y KTTLG+L Sbjct: 334 GIFVFSALGYTMEQSHPETLFKSIPQSFWWA-----IITMTTVGYGDIYPKTTLGKLNAA 388 Query: 371 FFILGGLAMFASYVPEII 388 L G+ A + II Sbjct: 389 ISFLCGVIAIALPIHPII 406 >gi|4826784 potassium voltage-gated channel, Shab-related subfamily, member 1 [Homo sapiens] Length = 858 Score = 62.8 bits (151), Expect = 2e-09 Identities = 44/180 (24%), Positives = 84/180 (46%), Gaps = 20/180 (11%) Query: 224 FFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG-LRFLRALRLIQF 282 +F + + LRF+++ K F+ + +D + P +V+++L S L+F R++Q Sbjct: 239 WFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQI 298 Query: 283 SEILQFLNILKTSN--------------SIKLVNLLSIFISTWLTAAGFIHLVENSGDPW 328 I++ L ILK + S + LL +F++ + + + Sbjct: 299 FRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDD 358 Query: 329 ENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEII 388 F++ A +W + TM+TVGYGD+Y KT LG++ + G+ + A +P I+ Sbjct: 359 TKFKSIPASFWWATI-----TMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIV 413 >gi|18375613 dachshund homolog 1 isoform b [Homo sapiens] Length = 558 Score = 61.6 bits (148), Expect = 4e-09 Identities = 41/73 (56%), Positives = 47/73 (64%), Gaps = 15/73 (20%) Query: 3 NGGGGGGG-------------SSGGGGGGGGSSLR--MSSNIHANHLSLDASSSSSSSSS 47 NGGGGGGG S+G GGGGGG S ++S+ N + +SSSSSSSSS Sbjct: 91 NGGGGGGGGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSS 150 Query: 48 SSSSSSSSSSSSS 60 SSSSSSSSSSSSS Sbjct: 151 SSSSSSSSSSSSS 163 Score = 59.7 bits (143), Expect = 2e-08 Identities = 36/77 (46%), Positives = 44/77 (57%), Gaps = 19/77 (24%) Query: 3 NGGGGGGGSSGGGGGGGGSSLRMSSNIH-------------------ANHLSLDASSSSS 43 +GGGGG +GGGGGGGG + N+ A+ ++AS+ SS Sbjct: 82 SGGGGGSSGNGGGGGGGGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSS 141 Query: 44 SSSSSSSSSSSSSSSSS 60 SSSSSSSSSSSSSSSSS Sbjct: 142 SSSSSSSSSSSSSSSSS 158 Score = 48.9 bits (115), Expect = 3e-05 Identities = 28/52 (53%), Positives = 34/52 (65%) Query: 2 ANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSS 53 +NG GGGGG GGG S+ +S ++ S +SSSSSSSSSSSSSSS Sbjct: 112 SNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSS 163 >gi|18375611 dachshund homolog 1 isoform a [Homo sapiens] Length = 706 Score = 61.6 bits (148), Expect = 4e-09 Identities = 41/73 (56%), Positives = 47/73 (64%), Gaps = 15/73 (20%) Query: 3 NGGGGGGG-------------SSGGGGGGGGSSLR--MSSNIHANHLSLDASSSSSSSSS 47 NGGGGGGG S+G GGGGGG S ++S+ N + +SSSSSSSSS Sbjct: 91 NGGGGGGGGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSS 150 Query: 48 SSSSSSSSSSSSS 60 SSSSSSSSSSSSS Sbjct: 151 SSSSSSSSSSSSS 163 Score = 59.7 bits (143), Expect = 2e-08 Identities = 36/77 (46%), Positives = 44/77 (57%), Gaps = 19/77 (24%) Query: 3 NGGGGGGGSSGGGGGGGGSSLRMSSNIH-------------------ANHLSLDASSSSS 43 +GGGGG +GGGGGGGG + N+ A+ ++AS+ SS Sbjct: 82 SGGGGGSSGNGGGGGGGGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSS 141 Query: 44 SSSSSSSSSSSSSSSSS 60 SSSSSSSSSSSSSSSSS Sbjct: 142 SSSSSSSSSSSSSSSSS 158 Score = 48.9 bits (115), Expect = 3e-05 Identities = 28/52 (53%), Positives = 34/52 (65%) Query: 2 ANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSS 53 +NG GGGGG GGG S+ +S ++ S +SSSSSSSSSSSSSSS Sbjct: 112 SNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSS 163 >gi|18375609 dachshund homolog 1 isoform c [Homo sapiens] Length = 504 Score = 61.6 bits (148), Expect = 4e-09 Identities = 41/73 (56%), Positives = 47/73 (64%), Gaps = 15/73 (20%) Query: 3 NGGGGGGG-------------SSGGGGGGGGSSLR--MSSNIHANHLSLDASSSSSSSSS 47 NGGGGGGG S+G GGGGGG S ++S+ N + +SSSSSSSSS Sbjct: 91 NGGGGGGGGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSS 150 Query: 48 SSSSSSSSSSSSS 60 SSSSSSSSSSSSS Sbjct: 151 SSSSSSSSSSSSS 163 Score = 59.7 bits (143), Expect = 2e-08 Identities = 36/77 (46%), Positives = 44/77 (57%), Gaps = 19/77 (24%) Query: 3 NGGGGGGGSSGGGGGGGGSSLRMSSNIH-------------------ANHLSLDASSSSS 43 +GGGGG +GGGGGGGG + N+ A+ ++AS+ SS Sbjct: 82 SGGGGGSSGNGGGGGGGGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSS 141 Query: 44 SSSSSSSSSSSSSSSSS 60 SSSSSSSSSSSSSSSSS Sbjct: 142 SSSSSSSSSSSSSSSSS 158 Score = 48.9 bits (115), Expect = 3e-05 Identities = 28/52 (53%), Positives = 34/52 (65%) Query: 2 ANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSS 53 +NG GGGGG GGG S+ +S ++ S +SSSSSSSSSSSSSSS Sbjct: 112 SNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSS 163 >gi|88758576 Shaw-related voltage-gated potassium channel protein 4 isoform c [Homo sapiens] Length = 626 Score = 59.3 bits (142), Expect = 2e-08 Identities = 56/194 (28%), Positives = 88/194 (45%), Gaps = 31/194 (15%) Query: 223 VFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLN-------RSWLG----L 271 ++F L F +R + D L F + +++DF + P ++ V L+ R LG + Sbjct: 290 LWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVV 349 Query: 272 RFLRALRLIQFSEILQFLNIL------KTSNSIKLVNLLSIFISTWLTAAGFIHLVENSG 325 RF+R LR+ + + L +L T+ + L+ L++ + L A I+ E G Sbjct: 350 RFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGV---LIFATMIYYAERIG 406 Query: 326 ----DPWENFQN---NQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLA 378 DP N N + +W V VTM+T+GYGD+Y KT G L L G+ Sbjct: 407 ARPSDPRGNDHTDFKNIPIGFWWAV----VTMTTLGYGDMYPKTWSGMLVGALCALAGVL 462 Query: 379 MFASYVPEIIELIG 392 A VP I+ G Sbjct: 463 TIAMPVPVIVNNFG 476 >gi|24497462 Shaw-related voltage-gated potassium channel protein 4 isoform a [Homo sapiens] Length = 635 Score = 59.3 bits (142), Expect = 2e-08 Identities = 56/194 (28%), Positives = 88/194 (45%), Gaps = 31/194 (15%) Query: 223 VFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLN-------RSWLG----L 271 ++F L F +R + D L F + +++DF + P ++ V L+ R LG + Sbjct: 290 LWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVV 349 Query: 272 RFLRALRLIQFSEILQFLNIL------KTSNSIKLVNLLSIFISTWLTAAGFIHLVENSG 325 RF+R LR+ + + L +L T+ + L+ L++ + L A I+ E G Sbjct: 350 RFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGV---LIFATMIYYAERIG 406 Query: 326 ----DPWENFQN---NQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLA 378 DP N N + +W V VTM+T+GYGD+Y KT G L L G+ Sbjct: 407 ARPSDPRGNDHTDFKNIPIGFWWAV----VTMTTLGYGDMYPKTWSGMLVGALCALAGVL 462 Query: 379 MFASYVPEIIELIG 392 A VP I+ G Sbjct: 463 TIAMPVPVIVNNFG 476 >gi|24497464 Shaw-related voltage-gated potassium channel protein 4 isoform b [Homo sapiens] Length = 582 Score = 59.3 bits (142), Expect = 2e-08 Identities = 56/194 (28%), Positives = 88/194 (45%), Gaps = 31/194 (15%) Query: 223 VFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLN-------RSWLG----L 271 ++F L F +R + D L F + +++DF + P ++ V L+ R LG + Sbjct: 290 LWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVV 349 Query: 272 RFLRALRLIQFSEILQFLNIL------KTSNSIKLVNLLSIFISTWLTAAGFIHLVENSG 325 RF+R LR+ + + L +L T+ + L+ L++ + L A I+ E G Sbjct: 350 RFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGV---LIFATMIYYAERIG 406 Query: 326 ----DPWENFQN---NQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLA 378 DP N N + +W V VTM+T+GYGD+Y KT G L L G+ Sbjct: 407 ARPSDPRGNDHTDFKNIPIGFWWAV----VTMTTLGYGDMYPKTWSGMLVGALCALAGVL 462 Query: 379 MFASYVPEIIELIG 392 A VP I+ G Sbjct: 463 TIAMPVPVIVNNFG 476 >gi|27436996 potassium voltage-gated channel, subfamily G, member 4 [Homo sapiens] Length = 519 Score = 58.5 bits (140), Expect = 4e-08 Identities = 48/182 (26%), Positives = 84/182 (46%), Gaps = 30/182 (16%) Query: 224 FFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSV-----------------YLNR 266 +F L F LRF+ A DK F+ +++D + P +VS+ YL + Sbjct: 272 WFSLEFCLRFVQAQDKCQFFQGPLNIIDILAISPYYVSLAVSEEPPEDGERPSGSSYLEK 331 Query: 267 SWLGLRFLRALRLIQFSEI------LQFLNILKTSNSIKLVNLLSIFISTWLTA-AGFIH 319 L LR LRALR++ + LQ L L + LL +F++ +T + ++ Sbjct: 332 VGLVLRVLRALRILYVMRLARHSLGLQTLG-LTVRRCTREFGLLLLFLAVAITLFSPLVY 390 Query: 320 LVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAM 379 + E F + A +W +++M+TVGYGD+ ++ G++ + IL G+ + Sbjct: 391 VAEKESGRVLEFTSIPASYWW-----AIISMTTVGYGDMVPRSVPGQMVALSSILSGILI 445 Query: 380 FA 381 A Sbjct: 446 MA 447 >gi|27436984 potassium voltage-gated channel, Shal-related subfamily, member 3 isoform 1 [Homo sapiens] Length = 655 Score = 57.8 bits (138), Expect = 6e-08 Identities = 47/191 (24%), Positives = 82/191 (42%), Gaps = 13/191 (6%) Query: 206 CQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLN 265 C Y +D A + F + + LR AA + F V S++D + P ++ + + Sbjct: 218 CGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMT 277 Query: 266 RS------WLGLRFLRALRLIQFSEILQFLNIL--KTSNSIKLVNLLSIFISTWLTAAGF 317 + ++ LR R R+ +FS Q L IL + + L ++ + Sbjct: 278 NNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFAT 337 Query: 318 IHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGL 377 + G F + A ++W + VTM+T+GYGD+ KT G++F L G+ Sbjct: 338 VMFYAEKGSSASKFTSIPA-SFWYTI----VTMTTLGYGDMVPKTIAGKIFGSICSLSGV 392 Query: 378 AMFASYVPEII 388 + A VP I+ Sbjct: 393 LVIALPVPVIV 403 >gi|27436986 potassium voltage-gated channel, Shal-related subfamily, member 3 isoform 2 [Homo sapiens] Length = 636 Score = 57.8 bits (138), Expect = 6e-08 Identities = 47/191 (24%), Positives = 82/191 (42%), Gaps = 13/191 (6%) Query: 206 CQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLN 265 C Y +D A + F + + LR AA + F V S++D + P ++ + + Sbjct: 218 CGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMT 277 Query: 266 RS------WLGLRFLRALRLIQFSEILQFLNIL--KTSNSIKLVNLLSIFISTWLTAAGF 317 + ++ LR R R+ +FS Q L IL + + L ++ + Sbjct: 278 NNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFAT 337 Query: 318 IHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGL 377 + G F + A ++W + VTM+T+GYGD+ KT G++F L G+ Sbjct: 338 VMFYAEKGSSASKFTSIPA-SFWYTI----VTMTTLGYGDMVPKTIAGKIFGSICSLSGV 392 Query: 378 AMFASYVPEII 388 + A VP I+ Sbjct: 393 LVIALPVPVIV 403 >gi|9789987 potassium voltage-gated channel, Shal-related subfamily, member 2 [Homo sapiens] Length = 630 Score = 55.8 bits (133), Expect = 2e-07 Identities = 45/180 (25%), Positives = 80/180 (44%), Gaps = 13/180 (7%) Query: 217 IDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYL------NRSWLG 270 +D A + F + + LR AA + F V S++D + P ++ + + + +++ Sbjct: 232 LDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVT 291 Query: 271 LRFLRALRLIQFSEILQFLNIL--KTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPW 328 LR R R+ +FS Q L IL + + L ++ + + G Sbjct: 292 LRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSA 351 Query: 329 ENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEII 388 F + A +W + VTM+T+GYGD+ KT G++F L G+ + A VP I+ Sbjct: 352 SKFTSIPA-AFWYTI----VTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIV 406 >gi|21217561 Shaw-related voltage-gated potassium channel protein 2 isoform KV3.2a [Homo sapiens] Length = 613 Score = 55.8 bits (133), Expect = 2e-07 Identities = 51/191 (26%), Positives = 88/191 (46%), Gaps = 25/191 (13%) Query: 223 VFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLN-------RSWLG----L 271 V+F F +R + + +KL F + +++DF + P ++ V L+ + LG + Sbjct: 291 VWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVV 350 Query: 272 RFLRALRLIQFSEILQFLNIL------KTSNSIKLVNLLSIFISTWLTAAGFIHLV---E 322 RF+R LR+ + + L +L T+ + L+ L++ + + T + V Sbjct: 351 RFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQP 410 Query: 323 NSGDPWENFQ-NNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFA 381 N E+ Q N + +W V VTM+T+GYGD+Y +T G L L G+ A Sbjct: 411 NDPSASEHTQFKNIPIGFWWAV----VTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIA 466 Query: 382 SYVPEIIELIG 392 VP I+ G Sbjct: 467 MPVPVIVNNFG 477 >gi|21217563 Shaw-related voltage-gated potassium channel protein 2 isoform KV3.2b [Homo sapiens] Length = 638 Score = 55.8 bits (133), Expect = 2e-07 Identities = 51/191 (26%), Positives = 88/191 (46%), Gaps = 25/191 (13%) Query: 223 VFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLN-------RSWLG----L 271 V+F F +R + + +KL F + +++DF + P ++ V L+ + LG + Sbjct: 291 VWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVV 350 Query: 272 RFLRALRLIQFSEILQFLNIL------KTSNSIKLVNLLSIFISTWLTAAGFIHLV---E 322 RF+R LR+ + + L +L T+ + L+ L++ + + T + V Sbjct: 351 RFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQP 410 Query: 323 NSGDPWENFQ-NNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFA 381 N E+ Q N + +W V VTM+T+GYGD+Y +T G L L G+ A Sbjct: 411 NDPSASEHTQFKNIPIGFWWAV----VTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIA 466 Query: 382 SYVPEIIELIG 392 VP I+ G Sbjct: 467 MPVPVIVNNFG 477 >gi|24497458 Shaw-related voltage-gated potassium channel protein 2 isoform KV3.2c [Homo sapiens] Length = 558 Score = 55.8 bits (133), Expect = 2e-07 Identities = 51/191 (26%), Positives = 88/191 (46%), Gaps = 25/191 (13%) Query: 223 VFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLN-------RSWLG----L 271 V+F F +R + + +KL F + +++DF + P ++ V L+ + LG + Sbjct: 291 VWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVV 350 Query: 272 RFLRALRLIQFSEILQFLNIL------KTSNSIKLVNLLSIFISTWLTAAGFIHLV---E 322 RF+R LR+ + + L +L T+ + L+ L++ + + T + V Sbjct: 351 RFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQP 410 Query: 323 NSGDPWENFQ-NNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFA 381 N E+ Q N + +W V VTM+T+GYGD+Y +T G L L G+ A Sbjct: 411 NDPSASEHTQFKNIPIGFWWAV----VTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIA 466 Query: 382 SYVPEIIELIG 392 VP I+ G Sbjct: 467 MPVPVIVNNFG 477 >gi|27436988 potassium voltage-gated channel, subfamily G, member 1 [Homo sapiens] Length = 513 Score = 55.5 bits (132), Expect = 3e-07 Identities = 50/188 (26%), Positives = 85/188 (45%), Gaps = 30/188 (15%) Query: 224 FFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSV-----------------YLNR 266 +F L F LR I A K F +++D + P ++++ YL++ Sbjct: 278 WFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDK 337 Query: 267 SWLGLRFLRALRLIQFSEI------LQFLNILKTSNSIKLVNLLSIFISTWLTA-AGFIH 319 L LR LRALR++ + LQ L L + LL +F+ + A ++ Sbjct: 338 VGLVLRVLRALRILYVMRLARHSLGLQTLG-LTARRCTREFGLLLLFLCVAIALFAPLLY 396 Query: 320 LVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAM 379 ++EN F + A +W ++TM+TVGYGD+ ++T G++ + IL G+ + Sbjct: 397 VIENEMADSPEFTSIPACYWWA-----VITMTTVGYGDMVPRSTPGQVVALSSILSGILL 451 Query: 380 FASYVPEI 387 A V I Sbjct: 452 MAFPVTSI 459 >gi|24497460 Shaw-related voltage-gated potassium channel protein 3 [Homo sapiens] Length = 757 Score = 54.7 bits (130), Expect = 5e-07 Identities = 53/192 (27%), Positives = 89/192 (46%), Gaps = 27/192 (14%) Query: 223 VFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLN-------RSWLG----L 271 V+F F +R DK+ F +++D + P ++ V L+ + LG + Sbjct: 357 VWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVV 416 Query: 272 RFLRALRLIQFSEILQFLNIL------KTSNSIKLVNLLSIFISTWLTAAGFIHLVENSG 325 RF+R LR+ + + L +L T+ + L+ L++ + L A I+ E G Sbjct: 417 RFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGV---LIFATMIYYAERIG 473 Query: 326 -DPWENFQNNQALTYWECV----YLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMF 380 DP + +N TY++ + + +VTM+T+GYGD+Y KT G L L G+ Sbjct: 474 ADPDDILGSNH--TYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTI 531 Query: 381 ASYVPEIIELIG 392 A VP I+ G Sbjct: 532 AMPVPVIVNNFG 543 >gi|4826786 Shaw-related voltage-gated potassium channel protein 1 isoform B [Homo sapiens] Length = 511 Score = 53.5 bits (127), Expect = 1e-06 Identities = 50/202 (24%), Positives = 89/202 (44%), Gaps = 27/202 (13%) Query: 213 FTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLN------- 265 F I+ V+F F +R I +K+ F +++DF + P ++ V L+ Sbjct: 244 FLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAA 303 Query: 266 RSWLG----LRFLRALRLIQFSEILQFLNIL------KTSNSIKLVNLLSIFISTWLTAA 315 + LG +RF+R LR+ + + L +L T+ + L+ L++ + + T Sbjct: 304 KDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMI 363 Query: 316 GFIHLV-----ENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMV 370 + + + S +F+N +W +VTM+T+GYGD+Y +T G L Sbjct: 364 YYAERIGAQPNDPSASEHTHFKNIPIGFWWA-----VVTMTTLGYGDMYPQTWSGMLVGA 418 Query: 371 FFILGGLAMFASYVPEIIELIG 392 L G+ A VP I+ G Sbjct: 419 LCALAGVLTIAMPVPVIVNNFG 440 >gi|163792201 Shaw-related voltage-gated potassium channel protein 1 isoform A [Homo sapiens] Length = 585 Score = 53.5 bits (127), Expect = 1e-06 Identities = 50/202 (24%), Positives = 89/202 (44%), Gaps = 27/202 (13%) Query: 213 FTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLN------- 265 F I+ V+F F +R I +K+ F +++DF + P ++ V L+ Sbjct: 244 FLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAA 303 Query: 266 RSWLG----LRFLRALRLIQFSEILQFLNIL------KTSNSIKLVNLLSIFISTWLTAA 315 + LG +RF+R LR+ + + L +L T+ + L+ L++ + + T Sbjct: 304 KDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMI 363 Query: 316 GFIHLV-----ENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMV 370 + + + S +F+N +W +VTM+T+GYGD+Y +T G L Sbjct: 364 YYAERIGAQPNDPSASEHTHFKNIPIGFWWA-----VVTMTTLGYGDMYPQTWSGMLVGA 418 Query: 371 FFILGGLAMFASYVPEIIELIG 392 L G+ A VP I+ G Sbjct: 419 LCALAGVLTIAMPVPVIVNNFG 440 >gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens] Length = 500 Score = 53.5 bits (127), Expect = 1e-06 Identities = 41/170 (24%), Positives = 72/170 (42%), Gaps = 22/170 (12%) Query: 229 FGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLN---------------RSWLGLRF 273 F LRF+ D+ F +V +++D + P ++++ + R LR Sbjct: 257 FVLRFLCVRDRCRFLRKVPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRL 316 Query: 274 LRALRLIQFSEILQFLNIL--KTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENF 331 LRALR+++ L L + + V LL +F+S ++ + P F Sbjct: 317 LRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTF 376 Query: 332 QNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFA 381 + +W +M+TVGYGD+ TT G++ IL G+ + A Sbjct: 377 TSVPCAWWWATT-----SMTTVGYGDIRPDTTTGKIVAFMCILSGILVLA 421 >gi|27436981 potassium voltage-gated channel, Shal-related subfamily, member 1 [Homo sapiens] Length = 647 Score = 52.8 bits (125), Expect = 2e-06 Identities = 45/180 (25%), Positives = 79/180 (43%), Gaps = 13/180 (7%) Query: 217 IDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRS------WLG 270 +D A + F + LR AA + F V S++D + P ++ + + ++ ++ Sbjct: 234 MDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVT 293 Query: 271 LRFLRALRLIQFSEILQFLNIL--KTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPW 328 LR R R+ +FS Q L IL + + L ++ + + G Sbjct: 294 LRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNK 353 Query: 329 ENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEII 388 NF + A +W + VTM+T+GYGD+ T G++F L G+ + A VP I+ Sbjct: 354 TNFTSIPA-AFWYTI----VTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIV 408 >gi|45383011 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2 [Homo sapiens] Length = 477 Score = 52.0 bits (123), Expect = 3e-06 Identities = 54/232 (23%), Positives = 98/232 (42%), Gaps = 25/232 (10%) Query: 165 WAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIE---SCQNFYKDFTLQIDMAF 221 W + ++ RV +L + +G+++ ++S + S N +D +I F Sbjct: 174 WLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHF 233 Query: 222 NV-FFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRAL-RL 279 + +F RF A D L F+ +++D ++ P ++++ +N L L R+ Sbjct: 234 GIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRV 293 Query: 280 IQFSEILQFLNILKTSN--------------SIKLVNLLSIFISTWLTAAGFIHLVENSG 325 Q +++ ILK + S K V LL +++S ++ + Sbjct: 294 AQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTI--- 350 Query: 326 DPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGL 377 E +N T C + V+M+TVGYGDV TT G+L IL G+ Sbjct: 351 ---EKEENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGI 399 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.135 0.407 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 43,406,918 Number of Sequences: 37866 Number of extensions: 1906527 Number of successful extensions: 31547 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 377 Number of HSP's successfully gapped in prelim test: 82 Number of HSP's that attempted gapping in prelim test: 18850 Number of HSP's gapped (non-prelim): 6951 length of query: 1178 length of database: 18,247,518 effective HSP length: 113 effective length of query: 1065 effective length of database: 13,968,660 effective search space: 14876622900 effective search space used: 14876622900 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.