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Search of human proteins with 25188201
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
(608 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 1225 0.0
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 506 e-143
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 460 e-129
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 460 e-129
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 441 e-124
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 441 e-124
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 436 e-122
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 436 e-122
gi|19115964 phospholipase C delta 3 [Homo sapiens] 435 e-122
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 312 5e-85
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 312 5e-85
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 298 7e-81
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 298 7e-81
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 297 2e-80
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 245 7e-65
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 244 2e-64
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 244 2e-64
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 244 2e-64
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 176 7e-44
gi|11386139 phospholipase C beta 3 [Homo sapiens] 175 1e-43
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 174 3e-43
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 174 3e-43
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 172 1e-42
gi|38570146 synaptotagmin VII [Homo sapiens] 41 0.003
gi|114520609 neural precursor cell expressed, developmentally do... 40 0.006
gi|238550198 synaptotagmin III [Homo sapiens] 39 0.014
gi|238550196 synaptotagmin III [Homo sapiens] 39 0.014
gi|14150054 synaptotagmin III [Homo sapiens] 39 0.014
gi|211059429 synaptotagmin II [Homo sapiens] 37 0.069
gi|31543670 synaptotagmin II [Homo sapiens] 37 0.069
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 1225 bits (3170), Expect = 0.0
Identities = 608/608 (100%), Positives = 608/608 (100%)
Query: 1 MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEF 60
MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEF
Sbjct: 1 MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEF 60
Query: 61 RAIYRIITHREEIIEIFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPI 120
RAIYRIITHREEIIEIFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPI
Sbjct: 61 RAIYRIITHREEIIEIFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPI 120
Query: 121 EEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLL 180
EEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLL
Sbjct: 121 EEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLL 180
Query: 181 GPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTS 240
GPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTS
Sbjct: 181 GPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTS 240
Query: 241 DYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKK 300
DYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKK
Sbjct: 241 DYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKK 300
Query: 301 IGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEK 360
IGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEK
Sbjct: 301 IGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEK 360
Query: 361 FKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNP 420
FKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNP
Sbjct: 361 FKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNP 420
Query: 421 QEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGM 480
QEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGM
Sbjct: 421 QEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGM 480
Query: 481 PITLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETF 540
PITLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETF
Sbjct: 481 PITLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETF 540
Query: 541 TFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASL 600
TFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASL
Sbjct: 541 TFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASL 600
Query: 601 FVYVWYVR 608
FVYVWYVR
Sbjct: 601 FVYVWYVR 608
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 506 bits (1303), Expect = e-143
Identities = 268/606 (44%), Positives = 375/606 (61%), Gaps = 14/606 (2%)
Query: 12 DDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHRE 71
D + GK++ ++ QRLL +++ + +F+ D + G + EEF Y+ +T R
Sbjct: 147 DKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRA 206
Query: 72 EIIEIFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSL 131
E+ E+F ++S + + L FL +EQ + + +A E+I +YEP + + H +S+
Sbjct: 207 EVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGKLRHVLSM 266
Query: 132 EGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSA 191
+GF Y+ S++ +F C +YQDMT PLN YFI SSHNTYLV DQL G S + GY+ A
Sbjct: 267 DGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLVGDQLCGQSSVEGYIRA 326
Query: 192 LVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENH 251
L +GCRC+E+D WDG EPVVYHG+TLTS++LFK V+ + +YAF TSDYPV+LSLE H
Sbjct: 327 LKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSLETH 386
Query: 252 CSTAQQEVMADNLQATFGESLLSDMLDD-FPDTLPSPEALKFKILVKNKKIGTLKETHER 310
CS QQ+ MA +L GE LLS LD P LPSPE L+ KILVK KK+ TL+E E
Sbjct: 387 CSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKILVKGKKL-TLEEDLEY 445
Query: 311 KGSDKRGDNQDKETGVK---------KLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKF 361
+ + + ++ E ++ + + KKK K + ALS LVIY K+ F
Sbjct: 446 EEEEAEPELEESELALESQFETEPEPQEQNLQNKDKKKKSKPILCPALSSLVIYLKSVSF 505
Query: 362 KSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQ 421
+SF HS+ + F E +S ET+A++L K +EF+ H ++R+YP R DSSN+NPQ
Sbjct: 506 RSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQ 565
Query: 422 EFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSN-IKEGM 480
E WN GCQMVA+N QT GL MD+ +G F NGG GY+LKP FLR+ +S F+P I
Sbjct: 566 ELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHPEKPISPFK 625
Query: 481 PITLTIRLISGIQLPLTHSSSNKG--DSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNE 538
TL I++ISG QLP + D LV +++FGV D +Q+T ++ N F+P W +
Sbjct: 626 AQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQ 685
Query: 539 TFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPA 598
T F + VPELA++RFVV + N+F+GQYTLP CM +GYR I L S+ G SL PA
Sbjct: 686 TLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPA 745
Query: 599 SLFVYV 604
S+FVY+
Sbjct: 746 SIFVYI 751
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 460 bits (1184), Expect = e-129
Identities = 254/600 (42%), Positives = 352/600 (58%), Gaps = 7/600 (1%)
Query: 12 DDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHRE 71
D + K++ ++ Q L++L+I+ + ++IF++ D + + EE A Y+++T R
Sbjct: 153 DKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRV 212
Query: 72 EIIEIFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSL 131
EI F + + + L L FL +Q A+A +I++YEP E + QM+
Sbjct: 213 EIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTK 272
Query: 132 EGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSA 191
+GF Y+ S + F R+VYQDM PL+ Y +SSSHNTYL+ DQL GPS Y+ A
Sbjct: 273 DGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRA 332
Query: 192 LVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENH 251
L KGCRCLE+DCWDG EP++YHGYT TSK+LF V++AI YAF S YPV+LSLENH
Sbjct: 333 LCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENH 392
Query: 252 CSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERK 311
C+ QQ VMA +L A G LL+ LD ++LPSPE LK KIL+K KK+G L
Sbjct: 393 CTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEG 452
Query: 312 GSDKRGDNQDKETGVKKLPGV--MLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQH-SR 368
G + + + E + V + K K KL++A LSD+VIY K+ F F
Sbjct: 453 GPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGT 512
Query: 369 LYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGC 428
Q F E S E +A +L + + F+ H ++RIYP R DSSN++P E WN GC
Sbjct: 513 PGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGC 572
Query: 429 QMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEG---MPITLT 485
Q+VALNFQTPG MD+ G+F DNG GY+LKP FLR+ FNP + +G L
Sbjct: 573 QIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLN 632
Query: 486 IRLISGIQLPLTHSSSNK-GDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFII 544
IR+ISG QLP + + N D V +E+ GV D +QT VI N F+P W+ F F +
Sbjct: 633 IRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEV 692
Query: 545 HVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFVYV 604
VP+LALIRF+VE + N+F+GQ T+PL + +GYR + L S+ G+ A+LFV +
Sbjct: 693 VVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKI 752
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 460 bits (1184), Expect = e-129
Identities = 254/600 (42%), Positives = 352/600 (58%), Gaps = 7/600 (1%)
Query: 12 DDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHRE 71
D + K++ ++ Q L++L+I+ + ++IF++ D + + EE A Y+++T R
Sbjct: 174 DKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRV 233
Query: 72 EIIEIFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSL 131
EI F + + + L L FL +Q A+A +I++YEP E + QM+
Sbjct: 234 EIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTK 293
Query: 132 EGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSA 191
+GF Y+ S + F R+VYQDM PL+ Y +SSSHNTYL+ DQL GPS Y+ A
Sbjct: 294 DGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRA 353
Query: 192 LVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENH 251
L KGCRCLE+DCWDG EP++YHGYT TSK+LF V++AI YAF S YPV+LSLENH
Sbjct: 354 LCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENH 413
Query: 252 CSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERK 311
C+ QQ VMA +L A G LL+ LD ++LPSPE LK KIL+K KK+G L
Sbjct: 414 CTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEG 473
Query: 312 GSDKRGDNQDKETGVKKLPGV--MLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQH-SR 368
G + + + E + V + K K KL++A LSD+VIY K+ F F
Sbjct: 474 GPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGT 533
Query: 369 LYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGC 428
Q F E S E +A +L + + F+ H ++RIYP R DSSN++P E WN GC
Sbjct: 534 PGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGC 593
Query: 429 QMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEG---MPITLT 485
Q+VALNFQTPG MD+ G+F DNG GY+LKP FLR+ FNP + +G L
Sbjct: 594 QIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLN 653
Query: 486 IRLISGIQLPLTHSSSNK-GDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFII 544
IR+ISG QLP + + N D V +E+ GV D +QT VI N F+P W+ F F +
Sbjct: 654 IRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEV 713
Query: 545 HVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFVYV 604
VP+LALIRF+VE + N+F+GQ T+PL + +GYR + L S+ G+ A+LFV +
Sbjct: 714 VVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKI 773
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 441 bits (1134), Expect = e-124
Identities = 238/576 (41%), Positives = 354/576 (61%), Gaps = 22/576 (3%)
Query: 41 KQIFKDNDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRKILLASNLAQFLTQEQ 100
K++ K D+ +T EEF ++ + R EI + +S N++ L +L FL EQ
Sbjct: 313 KELHKSKDKAGT-EVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQ 371
Query: 101 YAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHP 160
A +++ I+ EII KYEP +E ++ +S++GFT Y+ S +C +F E +KV QDM P
Sbjct: 372 GVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQP 431
Query: 161 LNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLT 220
L+ YFI+SSHNTYL+ DQ GPSD+ GY+ AL GCR +E+D WDG NEPV+Y G+T+T
Sbjct: 432 LSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMT 491
Query: 221 SKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDF 280
S+++F++VI I+KYAF S+YP++L LENHCS QQ+VM +++ G+ L + +
Sbjct: 492 SQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVE 551
Query: 281 PDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKK- 339
LPSP+ LK KIL+K KK+ + S GD D++ G + + ++
Sbjct: 552 ESYLPSPDVLKGKILIKAKKLSS-------NCSGVEGDVTDEDEGAEMSQRMGKENMEQP 604
Query: 340 ----TRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEF 395
++ ++ LS+LV K+ +FK FQ S Q++ E S E A K + +F
Sbjct: 605 NNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDF 664
Query: 396 IFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGS 455
+ + ++F+ R++P R DSSN NPQ+FW GCQ+VA+NFQTPGL MDL G F NG
Sbjct: 665 VNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNC 724
Query: 456 GYILKPHFLRESKSYFNPSNIKEGM----PITLTIRLISGIQLPLTHSSSNKGDSL---V 508
GY+L+P +RE S+F+ +N K+ + P L I++ISG P S KGD + V
Sbjct: 725 GYVLRPAIMREEVSFFS-ANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYV 783
Query: 509 IIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFIIHVPELALIRFVVEGQGLIAGNEFL 568
+E+ G+P D +Q+T+ + +N +P ++E+F F I++PELA++RFVV I G+EF+
Sbjct: 784 YVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYI-GDEFI 842
Query: 569 GQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFVYV 604
GQYT+P C+ GYR +PL S GE L ASLFV+V
Sbjct: 843 GQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHV 878
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 441 bits (1134), Expect = e-124
Identities = 238/576 (41%), Positives = 354/576 (61%), Gaps = 22/576 (3%)
Query: 41 KQIFKDNDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRKILLASNLAQFLTQEQ 100
K++ K D+ +T EEF ++ + R EI + +S N++ L +L FL EQ
Sbjct: 187 KELHKSKDKAGT-EVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQ 245
Query: 101 YAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHP 160
A +++ I+ EII KYEP +E ++ +S++GFT Y+ S +C +F E +KV QDM P
Sbjct: 246 GVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQP 305
Query: 161 LNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLT 220
L+ YFI+SSHNTYL+ DQ GPSD+ GY+ AL GCR +E+D WDG NEPV+Y G+T+T
Sbjct: 306 LSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMT 365
Query: 221 SKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDF 280
S+++F++VI I+KYAF S+YP++L LENHCS QQ+VM +++ G+ L + +
Sbjct: 366 SQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVE 425
Query: 281 PDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKK- 339
LPSP+ LK KIL+K KK+ + S GD D++ G + + ++
Sbjct: 426 ESYLPSPDVLKGKILIKAKKLSS-------NCSGVEGDVTDEDEGAEMSQRMGKENMEQP 478
Query: 340 ----TRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEF 395
++ ++ LS+LV K+ +FK FQ S Q++ E S E A K + +F
Sbjct: 479 NNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDF 538
Query: 396 IFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGS 455
+ + ++F+ R++P R DSSN NPQ+FW GCQ+VA+NFQTPGL MDL G F NG
Sbjct: 539 VNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNC 598
Query: 456 GYILKPHFLRESKSYFNPSNIKEGM----PITLTIRLISGIQLPLTHSSSNKGDSL---V 508
GY+L+P +RE S+F+ +N K+ + P L I++ISG P S KGD + V
Sbjct: 599 GYVLRPAIMREEVSFFS-ANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYV 657
Query: 509 IIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFIIHVPELALIRFVVEGQGLIAGNEFL 568
+E+ G+P D +Q+T+ + +N +P ++E+F F I++PELA++RFVV I G+EF+
Sbjct: 658 YVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYI-GDEFI 716
Query: 569 GQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFVYV 604
GQYT+P C+ GYR +PL S GE L ASLFV+V
Sbjct: 717 GQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHV 752
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 436 bits (1120), Expect = e-122
Identities = 240/602 (39%), Positives = 377/602 (62%), Gaps = 18/602 (2%)
Query: 13 DFRGGKINLEKTQ-RLLEKLDIRCSYIHVKQIFKDNDRLKQG---RITIEEFRAIYRIIT 68
D G I LE T L+++L+ ++ FK+ + K+ R+T EEF + +
Sbjct: 252 DVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELC 311
Query: 69 HREEIIEIFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQ 128
R E+ + S+N++ L A++L FL EQ +++ I +II++YE EE R+
Sbjct: 312 TRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDICLDIIRRYELSEEGRQKGF 371
Query: 129 MSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGY 188
++++GFT+Y+ S EC +F E +KV QDMT PL+ Y+I++SHNTYL+ DQ GP+D+ GY
Sbjct: 372 LAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGY 431
Query: 189 VSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSL 248
+ AL GCR +E+D DG+ NEP++ + +T+ + F++VI+ I+K+AF+ S+YP++L L
Sbjct: 432 IRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCL 491
Query: 249 ENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETH 308
NHCS QQ+VMA ++ FG L ++ LPSPE LK I+VK KK+ + +
Sbjct: 492 GNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMIIVKGKKLPSDPDVL 551
Query: 309 ERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSR 368
E + +D +D+E + + V ++K ++++ LSDLV K+ +++ F+ S
Sbjct: 552 EGEVTD-----EDEEAEMSRRMSVDYNGEQK--QIRLCRELSDLVSICKSVQYRDFELSM 604
Query: 369 LYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGC 428
Q + E S ET+A +++ +F+ + +KF++RIYP A R DSSN NPQ+FWN GC
Sbjct: 605 KSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGC 664
Query: 429 QMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYF--NPSNIKEGM-PITLT 485
Q+VA+NFQTPG MDL G FL NGG GY+L+P +R+ SYF N I G+ P+ L
Sbjct: 665 QIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALH 724
Query: 486 IRLISGIQLPLTHSSSNKGDSL---VIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTF 542
I++ISG P + KGD + V IE+ G+P D +Q+T+ +++N+ +P ++ETF F
Sbjct: 725 IKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEF 784
Query: 543 IIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFV 602
+++PELA+IRFVV I G+EF+GQYT+P C+ GYR +PL S +G+ +E +LFV
Sbjct: 785 QVNLPELAMIRFVVLDDDYI-GDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFV 843
Query: 603 YV 604
++
Sbjct: 844 HI 845
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 436 bits (1120), Expect = e-122
Identities = 240/602 (39%), Positives = 377/602 (62%), Gaps = 18/602 (2%)
Query: 13 DFRGGKINLEKTQ-RLLEKLDIRCSYIHVKQIFKDNDRLKQG---RITIEEFRAIYRIIT 68
D G I LE T L+++L+ ++ FK+ + K+ R+T EEF + +
Sbjct: 154 DVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELC 213
Query: 69 HREEIIEIFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQ 128
R E+ + S+N++ L A++L FL EQ +++ I +II++YE EE R+
Sbjct: 214 TRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDICLDIIRRYELSEEGRQKGF 273
Query: 129 MSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGY 188
++++GFT+Y+ S EC +F E +KV QDMT PL+ Y+I++SHNTYL+ DQ GP+D+ GY
Sbjct: 274 LAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGY 333
Query: 189 VSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSL 248
+ AL GCR +E+D DG+ NEP++ + +T+ + F++VI+ I+K+AF+ S+YP++L L
Sbjct: 334 IRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCL 393
Query: 249 ENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETH 308
NHCS QQ+VMA ++ FG L ++ LPSPE LK I+VK KK+ + +
Sbjct: 394 GNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMIIVKGKKLPSDPDVL 453
Query: 309 ERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSR 368
E + +D +D+E + + V ++K ++++ LSDLV K+ +++ F+ S
Sbjct: 454 EGEVTD-----EDEEAEMSRRMSVDYNGEQK--QIRLCRELSDLVSICKSVQYRDFELSM 506
Query: 369 LYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGC 428
Q + E S ET+A +++ +F+ + +KF++RIYP A R DSSN NPQ+FWN GC
Sbjct: 507 KSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGC 566
Query: 429 QMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYF--NPSNIKEGM-PITLT 485
Q+VA+NFQTPG MDL G FL NGG GY+L+P +R+ SYF N I G+ P+ L
Sbjct: 567 QIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALH 626
Query: 486 IRLISGIQLPLTHSSSNKGDSL---VIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTF 542
I++ISG P + KGD + V IE+ G+P D +Q+T+ +++N+ +P ++ETF F
Sbjct: 627 IKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEF 686
Query: 543 IIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFV 602
+++PELA+IRFVV I G+EF+GQYT+P C+ GYR +PL S +G+ +E +LFV
Sbjct: 687 QVNLPELAMIRFVVLDDDYI-GDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFV 745
Query: 603 YV 604
++
Sbjct: 746 HI 747
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 435 bits (1119), Expect = e-122
Identities = 241/597 (40%), Positives = 354/597 (59%), Gaps = 11/597 (1%)
Query: 12 DDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHRE 71
D + K++ ++ + LL +++ + ++ +FK+ D R+ E R + R
Sbjct: 195 DSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEGAEIEEFLRRLLKRP 254
Query: 72 EIIEIFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSL 131
E+ EIF+ YS ++L A L +FL ++Q + A A ++IQ YE E ++ M+L
Sbjct: 255 ELEEIFHQYSGEDRVLSAPELLEFL-EDQGEEGATLARAQQLIQTYELNETAKQHELMTL 313
Query: 132 EGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSA 191
+GF Y+ S E N V+QDM PL YFISSSHNTYL Q+ GPS YV A
Sbjct: 314 DGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRA 373
Query: 192 LVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENH 251
+GCRC+E+DCW+G EPV+YHG+TLTSK+LF+ V+QA+ +AF S YPV+LSLENH
Sbjct: 374 FAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENH 433
Query: 252 CSTAQQEVMADNLQATFGESLLSDMLDD-FPDTLPSPEALKFKILVKNKKIGTLKETHER 310
C QQ MA +L G+ L++ LD P+ LPSPE LK ++LVK KK+ + R
Sbjct: 434 CGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKLPAARSEDGR 493
Query: 311 KGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLY 370
SD+ + +D E +++ + K +I+ LS L +Y A + ++ +
Sbjct: 494 ALSDREEEEEDDEEEEEEVEAAAQRRLAK----QISPELSALAVYCHATRLRTLHPAPNA 549
Query: 371 QQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQM 430
Q + +S+ E +A+KL + + F+ H + +TR+YP R +S+N++PQE WN GCQ+
Sbjct: 550 PQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQL 609
Query: 431 VALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMP-ITLTIRLI 489
VALNFQTPG MDL G+FL NG GY+LKP LR+ S F+P G P TL+I+++
Sbjct: 610 VALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPE--YPGPPRTTLSIQVL 667
Query: 490 SGIQLPLTHSSSNKG--DSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFIIHVP 547
+ QLP ++ D LV IE+ GVP D +Q+T + N F+PRW +T F + P
Sbjct: 668 TAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAP 727
Query: 548 ELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFVYV 604
ELAL+RFVVE + N+F+GQ+TLPL + +GYR I L S+ G SL PA+LF+ +
Sbjct: 728 ELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQI 784
>gi|12083581 phosphoinositide-specific phospholipase C beta 1
isoform a [Homo sapiens]
Length = 1216
Score = 312 bits (800), Expect = 5e-85
Identities = 212/609 (34%), Positives = 328/609 (53%), Gaps = 65/609 (10%)
Query: 47 NDRLKQGRITIEEFRAIYRIITHREEIIEIFNTY-SENRKILLASNLAQFLTQEQYAAEM 105
ND + Q T E +R + R EI IF+ + ++++ L + F+ +Q +
Sbjct: 199 NDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRL 258
Query: 106 SKAI--------AFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDM 157
++ + +I+KYEP + + Q+S++GF RY+ E + E + +DM
Sbjct: 259 NEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDM 318
Query: 158 THPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDG--AQNEPVVYH 215
+ PL+ YFI+SSHNTYL + QL G S + Y L+ GCRC+E+DCW G A+ EPV+ H
Sbjct: 319 SQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITH 378
Query: 216 GYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHC-STAQQEVMADNLQATFGESLLS 274
G+T+T+++ FK VI+AI + AF TS +P++LS ENH S QQ MA+ + FG++LL
Sbjct: 379 GFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLM 438
Query: 275 DMLDDFP----DTLPSPEALKFKILVKNKK------IGTLKETHERKGS----------- 313
+ L+ +P LPSP L +KILVKNKK G+ K+ + S
Sbjct: 439 EPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE 498
Query: 314 ---------DKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSF 364
D D+ D + KK + + + +S+LV Y + KF+SF
Sbjct: 499 PSSPGAGEADTESDDDDDDDDCKK---SSMDEGTAGSEAMATEEMSNLVNYIQPVKFESF 555
Query: 365 QHSRLYQQFNENNSIGETQA-RKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEF 423
+ S+ + E +S ET+ +L+K V EF+ + + ++RIYPK TR DSSN+ PQ F
Sbjct: 556 EISKKRNKSFEMSSFVETKGLEQLTKSPV-EFVEYNKMQLSRIYPKGTRVDSSNYMPQLF 614
Query: 424 WNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNP--SNIKEGMP 481
WN GCQMVALNFQT L M + G + NG SGY LKP F+R +F+P I +G+
Sbjct: 615 WNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIV 674
Query: 482 I-TLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQ--QTRVIKKNAFSPRWNE 538
TL++++ISG L S K + V +++FG+P D ++ +T+ + NA +P W E
Sbjct: 675 ANTLSVKIISGQFL-----SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEE 729
Query: 539 ---TFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESL 595
F ++ +P LA +R V + G +F+G LP+ + GY I L + + L
Sbjct: 730 EPIVFKKVV-LPTLACLRIAVYEE----GGKFIGHRILPVQAIRPGYHYICLRNERNQPL 784
Query: 596 EPASLFVYV 604
++FVY+
Sbjct: 785 TLPAVFVYI 793
>gi|33356544 phosphoinositide-specific phospholipase C beta 1
isoform b [Homo sapiens]
Length = 1173
Score = 312 bits (800), Expect = 5e-85
Identities = 212/609 (34%), Positives = 328/609 (53%), Gaps = 65/609 (10%)
Query: 47 NDRLKQGRITIEEFRAIYRIITHREEIIEIFNTY-SENRKILLASNLAQFLTQEQYAAEM 105
ND + Q T E +R + R EI IF+ + ++++ L + F+ +Q +
Sbjct: 199 NDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRL 258
Query: 106 SKAI--------AFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDM 157
++ + +I+KYEP + + Q+S++GF RY+ E + E + +DM
Sbjct: 259 NEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDM 318
Query: 158 THPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDG--AQNEPVVYH 215
+ PL+ YFI+SSHNTYL + QL G S + Y L+ GCRC+E+DCW G A+ EPV+ H
Sbjct: 319 SQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITH 378
Query: 216 GYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHC-STAQQEVMADNLQATFGESLLS 274
G+T+T+++ FK VI+AI + AF TS +P++LS ENH S QQ MA+ + FG++LL
Sbjct: 379 GFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLM 438
Query: 275 DMLDDFP----DTLPSPEALKFKILVKNKK------IGTLKETHERKGS----------- 313
+ L+ +P LPSP L +KILVKNKK G+ K+ + S
Sbjct: 439 EPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE 498
Query: 314 ---------DKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSF 364
D D+ D + KK + + + +S+LV Y + KF+SF
Sbjct: 499 PSSPGAGEADTESDDDDDDDDCKK---SSMDEGTAGSEAMATEEMSNLVNYIQPVKFESF 555
Query: 365 QHSRLYQQFNENNSIGETQA-RKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEF 423
+ S+ + E +S ET+ +L+K V EF+ + + ++RIYPK TR DSSN+ PQ F
Sbjct: 556 EISKKRNKSFEMSSFVETKGLEQLTKSPV-EFVEYNKMQLSRIYPKGTRVDSSNYMPQLF 614
Query: 424 WNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNP--SNIKEGMP 481
WN GCQMVALNFQT L M + G + NG SGY LKP F+R +F+P I +G+
Sbjct: 615 WNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIV 674
Query: 482 I-TLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQ--QTRVIKKNAFSPRWNE 538
TL++++ISG L S K + V +++FG+P D ++ +T+ + NA +P W E
Sbjct: 675 ANTLSVKIISGQFL-----SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEE 729
Query: 539 ---TFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESL 595
F ++ +P LA +R V + G +F+G LP+ + GY I L + + L
Sbjct: 730 EPIVFKKVV-LPTLACLRIAVYEE----GGKFIGHRILPVQAIRPGYHYICLRNERNQPL 784
Query: 596 EPASLFVYV 604
++FVY+
Sbjct: 785 TLPAVFVYI 793
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 298 bits (764), Expect = 7e-81
Identities = 210/637 (32%), Positives = 321/637 (50%), Gaps = 99/637 (15%)
Query: 47 NDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRK-ILLASNLAQFLTQEQYAAEM 105
ND ++ + E+F + + I R +I ++F + ++ L L FL + Q +
Sbjct: 196 NDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRL 255
Query: 106 SKAI--------AFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDM 157
++ + A +II+ YEP E+++K +S +GF RY+ S E + ++YQ+M
Sbjct: 256 NEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEM 315
Query: 158 THPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGA--QNEPVVYH 215
HPL YFISSSHNTYL Q G S + Y L+ GCRC+E+DCWDG EP++ H
Sbjct: 316 DHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITH 375
Query: 216 GYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSD 275
G + + +LFK VIQAI + AF+TS+YPV+LS ENHCS QQ M+ + FG+ LL
Sbjct: 376 GKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQ 435
Query: 276 MLDDFP----DTLPSPEALKFKIL---------VKNKKIGTLKETHERKGS--------- 313
L+ P LPSP LK KIL V+ K++ L+ E S
Sbjct: 436 ALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGESASPANILED 495
Query: 314 ---------------------------DKRGDNQDKETGVKKLPGVMLFKKKKT------ 340
D G + VKK G++ + ++
Sbjct: 496 DNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKK--GLVTVEDEQAWMASYK 553
Query: 341 ---RKLKIALALSDLVIYTKAEKFKSF----QHSRLYQQFNENNSIGETQARKLSKLRVH 393
I LS ++ Y + KF+ F + + Y + N S+G L L+ H
Sbjct: 554 YVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG------LGYLKTH 607
Query: 394 --EFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLD 451
EF+ + ++ ++RIYPK R DSSN+ PQ FWN GCQMV+LN+QTP L M L GKF
Sbjct: 608 AIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEY 667
Query: 452 NGGSGYILKPHFLRESKSYFNP---SNIKEGMPITLTIRLISGIQLPLTHSSSNKGDSLV 508
NG GY+LKP F+R F+P + + + T ++++ISG L S K + V
Sbjct: 668 NGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFL-----SDKKIGTYV 722
Query: 509 IIEVFGVPNDQMKQQ--TRVIKKNAFSPRWN-ETFTF-IIHVPELALIRFVVEGQGLIAG 564
++++G+P D ++++ TR++ N +P +N E+F F + +P+LA++R V
Sbjct: 723 EVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDD----N 778
Query: 565 NEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASLF 601
N+ +GQ LPL + GYR I L + + L ++F
Sbjct: 779 NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 298 bits (764), Expect = 7e-81
Identities = 210/637 (32%), Positives = 321/637 (50%), Gaps = 99/637 (15%)
Query: 47 NDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRK-ILLASNLAQFLTQEQYAAEM 105
ND ++ + E+F + + I R +I ++F + ++ L L FL + Q +
Sbjct: 196 NDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRL 255
Query: 106 SKAI--------AFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDM 157
++ + A +II+ YEP E+++K +S +GF RY+ S E + ++YQ+M
Sbjct: 256 NEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEM 315
Query: 158 THPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGA--QNEPVVYH 215
HPL YFISSSHNTYL Q G S + Y L+ GCRC+E+DCWDG EP++ H
Sbjct: 316 DHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITH 375
Query: 216 GYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSD 275
G + + +LFK VIQAI + AF+TS+YPV+LS ENHCS QQ M+ + FG+ LL
Sbjct: 376 GKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQ 435
Query: 276 MLDDFP----DTLPSPEALKFKIL---------VKNKKIGTLKETHERKGS--------- 313
L+ P LPSP LK KIL V+ K++ L+ E S
Sbjct: 436 ALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGESASPANILED 495
Query: 314 ---------------------------DKRGDNQDKETGVKKLPGVMLFKKKKT------ 340
D G + VKK G++ + ++
Sbjct: 496 DNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKK--GLVTVEDEQAWMASYK 553
Query: 341 ---RKLKIALALSDLVIYTKAEKFKSF----QHSRLYQQFNENNSIGETQARKLSKLRVH 393
I LS ++ Y + KF+ F + + Y + N S+G L L+ H
Sbjct: 554 YVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG------LGYLKTH 607
Query: 394 --EFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLD 451
EF+ + ++ ++RIYPK R DSSN+ PQ FWN GCQMV+LN+QTP L M L GKF
Sbjct: 608 AIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEY 667
Query: 452 NGGSGYILKPHFLRESKSYFNP---SNIKEGMPITLTIRLISGIQLPLTHSSSNKGDSLV 508
NG GY+LKP F+R F+P + + + T ++++ISG L S K + V
Sbjct: 668 NGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFL-----SDKKIGTYV 722
Query: 509 IIEVFGVPNDQMKQQ--TRVIKKNAFSPRWN-ETFTF-IIHVPELALIRFVVEGQGLIAG 564
++++G+P D ++++ TR++ N +P +N E+F F + +P+LA++R V
Sbjct: 723 EVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDD----N 778
Query: 565 NEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASLF 601
N+ +GQ LPL + GYR I L + + L ++F
Sbjct: 779 NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 297 bits (760), Expect = 2e-80
Identities = 211/620 (34%), Positives = 308/620 (49%), Gaps = 77/620 (12%)
Query: 47 NDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRK-ILLASNLAQFLTQEQYAAEM 105
ND + +++ + R EI EIF +Y K + +L +F+ Q+Q + +
Sbjct: 195 NDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRL 254
Query: 106 SKAI--------AFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDM 157
+ + +I KYEP + Q+S EG ++ E + + ++ DM
Sbjct: 255 NSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDM 314
Query: 158 THPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDG--AQNEPVVYH 215
T PLN YFI+SSHNTYL + Q G S Y L+ GCRC+E+DCW G EP++ H
Sbjct: 315 TQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITH 374
Query: 216 GYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHC-STAQQEVMADNLQATFGESLLS 274
G+T+T+ + FK I+AI + AF TS YP++LS ENH S QQ MA+ + FG+ LL+
Sbjct: 375 GFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLT 434
Query: 275 DMLDDFP----DTLPSPEALKFKILVKNKK----------------------------IG 302
+ L+ FP LPSPE L+ KIL+KNKK G
Sbjct: 435 EPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEG 494
Query: 303 T---------LKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIAL--ALSD 351
T L+E + ++ N D+E +KK+ + T L++ +S
Sbjct: 495 TVWAGEEGTELEEEEVEEEEEEESGNLDEEE-IKKMQ-----SDEGTAGLEVTAYEEMSS 548
Query: 352 LVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKAT 411
LV Y + KF SF+ S + +S E +A L +F+ + ++ ++RIYPK T
Sbjct: 549 LVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGT 608
Query: 412 RADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYF 471
R DSSN+ PQ FWN GCQMVALNFQT LPM F NG SGY+LK F+R F
Sbjct: 609 RMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQF 668
Query: 472 NP---SNIKEGMPITLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQTRVI- 527
NP I + TL+I +ISG L S + V +E+FG+P D ++ +
Sbjct: 669 NPFSVDRIDVVVATTLSITVISGQFL-----SERSVRTYVEVELFGLPGDPKRRYRTKLS 723
Query: 528 -KKNAFSPRW-NETFTF-IIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRR 584
N+ +P W E F F I +PELA +R V + GN+FLG +P+ +N GY
Sbjct: 724 PSTNSINPVWKEEPFVFEKILMPELASLRVAV----MEEGNKFLGHRIIPINALNSGYHH 779
Query: 585 IPLFSRMGESLEPASLFVYV 604
+ L S L +LF+++
Sbjct: 780 LCLHSESNMPLTMPALFIFL 799
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 245 bits (626), Expect = 7e-65
Identities = 132/308 (42%), Positives = 192/308 (62%), Gaps = 2/308 (0%)
Query: 17 GKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLK-QGRITIEEFRAIYRIITHREEIIE 75
G +++ + +LL KL++ VKQ+F++ D QG + EEF A Y++++ R ++
Sbjct: 187 GSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYL 246
Query: 76 IFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFT 135
+ TYS ++ L A++L +FL EQ A ++ +II+++EP E + + ++GFT
Sbjct: 247 LMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLLGIDGFT 306
Query: 136 RYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKG 195
Y S +F E V+QDMT PL+ YFI+SSHNTYLV DQL+ S + Y L G
Sbjct: 307 NYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAG 366
Query: 196 CRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTA 255
CRC+E+DCWDG EP+V+HGYTLTSK+LFK VI+ I+KYAF+ ++YPV+LS+ENHCS
Sbjct: 367 CRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVI 426
Query: 256 QQEVMADNLQATFGESL-LSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSD 314
QQ+ MA L G+ L LS + + TLPSP+ LK KILVK KK+ +G
Sbjct: 427 QQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISEDAEEGEV 486
Query: 315 KRGDNQDK 322
D+ D+
Sbjct: 487 SDEDSADE 494
Score = 188 bits (478), Expect = 1e-47
Identities = 121/317 (38%), Positives = 179/317 (56%), Gaps = 35/317 (11%)
Query: 297 KNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYT 356
K KK +++E E G D G T ++KKT +K++ ALSDLV YT
Sbjct: 589 KLKKAASVEEGDE--GQDSPGGQSRGAT-----------RQKKT--MKLSRALSDLVKYT 633
Query: 357 KAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSS 416
K+ + + +S ET+A ++ + + +++ ++ ++RIYP + R DSS
Sbjct: 634 KSVATHDIEMEAASSW--QVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSS 691
Query: 417 NFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNI 476
N+NPQ FWN GCQMVALN+Q+ G + L KF NGG GY+LKP + + FNP N
Sbjct: 692 NYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCM--CQGVFNP-NS 748
Query: 477 KEGMP----ITLTIRLISGIQLPLTHSS--SNKG---DSLVIIEVFGVPNDQMKQQTRVI 527
++ +P L +R+ISG QLP S ++G D V +E+ G+P D ++QTRV+
Sbjct: 749 EDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVV 808
Query: 528 KKNAFSPRWNETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPL 587
N F+P W ET F++H+PE+AL+RF+V I G +F+GQ TL M GYR + L
Sbjct: 809 DDNGFNPTWEETLVFMVHMPEIALVRFLVWDHDPI-GRDFIGQRTLAFSSMMPGYRHVYL 867
Query: 588 FSRMGESLEPASLFVYV 604
E +E AS+FV+V
Sbjct: 868 -----EGMEEASIFVHV 879
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 244 bits (623), Expect = 2e-64
Identities = 125/287 (43%), Positives = 187/287 (65%), Gaps = 2/287 (0%)
Query: 17 GKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLK-QGRITIEEFRAIYRIITHREEIIE 75
G +N+E+ +L+ KL++ V+Q+F++ D + QG +T EEF Y++++ R ++
Sbjct: 160 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYL 219
Query: 76 IFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFT 135
+ +YS+ + L LAQFL EQ ++ +II+K+E EE + + + +EGFT
Sbjct: 220 LLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFT 279
Query: 136 RYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKG 195
+M S C +F +VYQDM PL +Y+I+SSHNTYL DQLL S + Y L +G
Sbjct: 280 NFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEG 339
Query: 196 CRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTA 255
CRC+E+DCWDG EPVV+HGYTLTSK+LF+ V++ I+K+AF+ +++PV+LS+ENHCS
Sbjct: 340 CRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQ 399
Query: 256 QQEVMADNLQATFGESL-LSDMLDDFPDTLPSPEALKFKILVKNKKI 301
QQ +A L+ FG+ L LS + LPSP++LK KILVK KK+
Sbjct: 400 QQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKL 446
Score = 187 bits (475), Expect = 2e-47
Identities = 118/313 (37%), Positives = 169/313 (53%), Gaps = 29/313 (9%)
Query: 305 KETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSF 364
K T R S D +D + K G + ++ + +K+ LSDLV+YT S
Sbjct: 557 KTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTN-----SV 611
Query: 365 QHSRLYQQFNENN--SIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQE 422
+ N S ET+A ++ + + +F+ + +K +TRIYP A R DSSNFNP
Sbjct: 612 AAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLP 671
Query: 423 FWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMPI 482
+WN GCQ+VALN+Q+ G M L KF NG GY+LKP + K FNP + G P+
Sbjct: 672 YWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ--QMCKGTFNPFS---GDPL 726
Query: 483 ------TLTIRLISGIQLPLTHSS--SNKG---DSLVIIEVFGVPNDQMKQQTRVIKKNA 531
L +++ISG QLP S ++G D V +E+ G+P D K QTRV+ N
Sbjct: 727 PANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNG 786
Query: 532 FSPRWNETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRM 591
F+P W ET TF +H+PE+AL+RF+V I G +F+GQ T+ + GYR + L
Sbjct: 787 FNPVWEETLTFTVHMPEIALVRFLVWDHDPI-GRDFVGQRTVTFSSLVPGYRHVYL---- 841
Query: 592 GESLEPASLFVYV 604
E L AS+FV++
Sbjct: 842 -EGLTEASIFVHI 853
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 244 bits (623), Expect = 2e-64
Identities = 125/287 (43%), Positives = 187/287 (65%), Gaps = 2/287 (0%)
Query: 17 GKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLK-QGRITIEEFRAIYRIITHREEIIE 75
G +N+E+ +L+ KL++ V+Q+F++ D + QG +T EEF Y++++ R ++
Sbjct: 160 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYL 219
Query: 76 IFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFT 135
+ +YS+ + L LAQFL EQ ++ +II+K+E EE + + + +EGFT
Sbjct: 220 LLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFT 279
Query: 136 RYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKG 195
+M S C +F +VYQDM PL +Y+I+SSHNTYL DQLL S + Y L +G
Sbjct: 280 NFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEG 339
Query: 196 CRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTA 255
CRC+E+DCWDG EPVV+HGYTLTSK+LF+ V++ I+K+AF+ +++PV+LS+ENHCS
Sbjct: 340 CRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQ 399
Query: 256 QQEVMADNLQATFGESL-LSDMLDDFPDTLPSPEALKFKILVKNKKI 301
QQ +A L+ FG+ L LS + LPSP++LK KILVK KK+
Sbjct: 400 QQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKL 446
Score = 187 bits (475), Expect = 2e-47
Identities = 118/313 (37%), Positives = 169/313 (53%), Gaps = 29/313 (9%)
Query: 305 KETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSF 364
K T R S D +D + K G + ++ + +K+ LSDLV+YT S
Sbjct: 557 KTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTN-----SV 611
Query: 365 QHSRLYQQFNENN--SIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQE 422
+ N S ET+A ++ + + +F+ + +K +TRIYP A R DSSNFNP
Sbjct: 612 AAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLP 671
Query: 423 FWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMPI 482
+WN GCQ+VALN+Q+ G M L KF NG GY+LKP + K FNP + G P+
Sbjct: 672 YWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ--QMCKGTFNPFS---GDPL 726
Query: 483 ------TLTIRLISGIQLPLTHSS--SNKG---DSLVIIEVFGVPNDQMKQQTRVIKKNA 531
L +++ISG QLP S ++G D V +E+ G+P D K QTRV+ N
Sbjct: 727 PANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNG 786
Query: 532 FSPRWNETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRM 591
F+P W ET TF +H+PE+AL+RF+V I G +F+GQ T+ + GYR + L
Sbjct: 787 FNPVWEETLTFTVHMPEIALVRFLVWDHDPI-GRDFVGQRTVTFSSLVPGYRHVYL---- 841
Query: 592 GESLEPASLFVYV 604
E L AS+FV++
Sbjct: 842 -EGLTEASIFVHI 853
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 244 bits (623), Expect = 2e-64
Identities = 125/287 (43%), Positives = 187/287 (65%), Gaps = 2/287 (0%)
Query: 17 GKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLK-QGRITIEEFRAIYRIITHREEIIE 75
G +N+E+ +L+ KL++ V+Q+F++ D + QG +T EEF Y++++ R ++
Sbjct: 142 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYL 201
Query: 76 IFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFT 135
+ +YS+ + L LAQFL EQ ++ +II+K+E EE + + + +EGFT
Sbjct: 202 LLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFT 261
Query: 136 RYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKG 195
+M S C +F +VYQDM PL +Y+I+SSHNTYL DQLL S + Y L +G
Sbjct: 262 NFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEG 321
Query: 196 CRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTA 255
CRC+E+DCWDG EPVV+HGYTLTSK+LF+ V++ I+K+AF+ +++PV+LS+ENHCS
Sbjct: 322 CRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQ 381
Query: 256 QQEVMADNLQATFGESL-LSDMLDDFPDTLPSPEALKFKILVKNKKI 301
QQ +A L+ FG+ L LS + LPSP++LK KILVK KK+
Sbjct: 382 QQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKL 428
Score = 187 bits (475), Expect = 2e-47
Identities = 118/313 (37%), Positives = 169/313 (53%), Gaps = 29/313 (9%)
Query: 305 KETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSF 364
K T R S D +D + K G + ++ + +K+ LSDLV+YT S
Sbjct: 539 KTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTN-----SV 593
Query: 365 QHSRLYQQFNENN--SIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQE 422
+ N S ET+A ++ + + +F+ + +K +TRIYP A R DSSNFNP
Sbjct: 594 AAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLP 653
Query: 423 FWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMPI 482
+WN GCQ+VALN+Q+ G M L KF NG GY+LKP + K FNP + G P+
Sbjct: 654 YWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ--QMCKGTFNPFS---GDPL 708
Query: 483 ------TLTIRLISGIQLPLTHSS--SNKG---DSLVIIEVFGVPNDQMKQQTRVIKKNA 531
L +++ISG QLP S ++G D V +E+ G+P D K QTRV+ N
Sbjct: 709 PANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNG 768
Query: 532 FSPRWNETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRM 591
F+P W ET TF +H+PE+AL+RF+V I G +F+GQ T+ + GYR + L
Sbjct: 769 FNPVWEETLTFTVHMPEIALVRFLVWDHDPI-GRDFVGQRTVTFSSLVPGYRHVYL---- 823
Query: 592 GESLEPASLFVYV 604
E L AS+FV++
Sbjct: 824 -EGLTEASIFVHI 835
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 176 bits (445), Expect = 7e-44
Identities = 91/196 (46%), Positives = 130/196 (66%), Gaps = 9/196 (4%)
Query: 113 IIQKYEPIEEVRKAHQ--MSLEGFTRYMDSRECLLFKN-ECRKVYQDMTHPLNDYFISSS 169
IIQK+EP + HQ MS EGF R++ +E KN E ++ +++ PL+ Y+I SS
Sbjct: 1349 IIQKFEP--SISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLSYYYIESS 1406
Query: 170 HNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVI 229
HNTYL QL G S + Y L++GCR +E+DCWDG P++YHG+TLT+K+ FK V+
Sbjct: 1407 HNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMPIIYHGHTLTTKIPFKEVV 1466
Query: 230 QAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDML--DDFPD--TLP 285
+AI + AF+ SD P+++S+ENHCS QQ MA+ + FGE L++ L DF D LP
Sbjct: 1467 EAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEKLVTKFLFETDFSDDPMLP 1526
Query: 286 SPEALKFKILVKNKKI 301
SP+ L+ K+L+KNKK+
Sbjct: 1527 SPDQLRKKVLLKNKKL 1542
Score = 131 bits (329), Expect = 2e-30
Identities = 81/233 (34%), Positives = 122/233 (52%), Gaps = 14/233 (6%)
Query: 377 NSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQ 436
+S+ E A++L + + HT + R YP ATR DSSN NP FW G Q+VALN+Q
Sbjct: 1758 SSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQ 1817
Query: 437 TPGLPMDLQNGKFLDNGGSGYILKPHFLRESK----SYFNP--SNIKEGMPITLTIRLIS 490
T LP+ L F NGG GY+LKP L + F+P ++ P ++ ++S
Sbjct: 1818 TDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDLDSMDPAVYSLTIVS 1877
Query: 491 GIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFIIHVPELA 550
G + S++ G + ++V G+P D +T+ I +N +P WNE F F +H +L
Sbjct: 1878 GQNV---CPSNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFHVHFEDLV 1934
Query: 551 LIRF-VVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFV 602
+RF VVE + Q +PL + +GYR + L + E LE +SLF+
Sbjct: 1935 FLRFAVVENN----SSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFI 1983
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 175 bits (443), Expect = 1e-43
Identities = 101/273 (36%), Positives = 160/273 (58%), Gaps = 16/273 (5%)
Query: 44 FKDNDRLKQGRITIEEFRAIYRIITHREEIIEIF-NTYSENRKILLASNLAQFLTQEQYA 102
F ++ ++ ++E F + R +I +I ++ + L L F+ Q+Q
Sbjct: 197 FNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRD 256
Query: 103 AEMSKAI--------AFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVY 154
+++ + A +I+KYEP ++ + QMS+EGF+RY+ E + E +
Sbjct: 257 PRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLS 316
Query: 155 QDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDG--AQNEPV 212
DMT PL+ YFI+SSHNTYL + QL G S + Y AL+ GCRC+E+D W G + EP
Sbjct: 317 TDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPF 376
Query: 213 VYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEV-MADNLQATFGES 271
+ HG+T+T+++ + V++AI + AF TS YPV+LS ENH +A+Q+ MA+ ++ FG++
Sbjct: 377 ITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDA 436
Query: 272 LLSDMLDDFP----DTLPSPEALKFKILVKNKK 300
LL + LD +P LPSP+ L +ILVKNKK
Sbjct: 437 LLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKK 469
Score = 149 bits (377), Expect = 6e-36
Identities = 98/261 (37%), Positives = 147/261 (56%), Gaps = 15/261 (5%)
Query: 349 LSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYP 408
+S LV Y + KFKSF+ +R + E +S ET+A + EF+ + ++ ++RIYP
Sbjct: 590 MSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYP 649
Query: 409 KATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESK 468
K TR DSSN+ PQ FWN+GCQ+VALNFQT + M L G F NG SGY+LKP F+R
Sbjct: 650 KGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPD 709
Query: 469 SYFNPSN--IKEGMPI-TLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPND-QMKQQT 524
F+P I +G+ L +++ISG L S K V +++FG+P D + K +T
Sbjct: 710 KSFDPFTEVIVDGIVANALRVKVISGQFL-----SDRKVGIYVEVDMFGLPVDTRRKYRT 764
Query: 525 RVIKKNAFSPRWN-ETFTF-IIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGY 582
R + N+F+P W+ E F F + +P LA +R + G +F+G LP+ + GY
Sbjct: 765 RTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEE----GGKFVGHRILPVSAIRSGY 820
Query: 583 RRIPLFSRMGESLEPASLFVY 603
+ L + + L +L +Y
Sbjct: 821 HYVCLRNEANQPLCLPALLIY 841
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 174 bits (440), Expect = 3e-43
Identities = 103/313 (32%), Positives = 168/313 (53%), Gaps = 16/313 (5%)
Query: 4 RWFLSKIQ--DDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFR 61
RW + D R +I+ + + +L +++ R + + + + G IT +F
Sbjct: 155 RWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFA 214
Query: 62 AIYRIITHREE------IIEIFNTYSENRKILLASNLAQF------LTQEQYAAEMSKAI 109
+YR + + + +E + R L +L +F E +A + +
Sbjct: 215 QLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQ 274
Query: 110 AFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQD-MTHPLNDYFISS 168
F + +P+ E+ + + L+ F ++ S+E ++ ++ V D M +PL+ Y+ISS
Sbjct: 275 EFMLSFLRDPLREIEEPY-FFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISS 333
Query: 169 SHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTV 228
SHNTYL DQ S L Y L GCRC+E+DCWDG PV+YHG+TLT+K+ F V
Sbjct: 334 SHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDV 393
Query: 229 IQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPE 288
+ I ++AF+ S+YPV+LS+E+HCS AQQ MA + G++LL+ ++ D LPSP
Sbjct: 394 LHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEISADGLPSPN 453
Query: 289 ALKFKILVKNKKI 301
LK KIL+K+KK+
Sbjct: 454 QLKRKILIKHKKL 466
Score = 153 bits (386), Expect = 5e-37
Identities = 95/269 (35%), Positives = 145/269 (53%), Gaps = 9/269 (3%)
Query: 341 RKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARK-LSKLRVHEFIFHT 399
R+ KIAL LS+LV+Y + F + + + +S ET+A K ++K + +F+ +
Sbjct: 945 RRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYN 1004
Query: 400 RKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYIL 459
R ++RIYPK R DSSN++P W G Q+VALNFQTP PM + F+ GY+L
Sbjct: 1005 RLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVL 1064
Query: 460 KPHFLR-ESKSYFNPSNIKEGMPITLTIRLISGIQLPLTHSSSNKG--DSLVIIEVFGVP 516
+P +R E+ F+ S+++ P ++I ++ LP + +G V IEV G
Sbjct: 1065 QPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLP----KNGRGIVCPFVEIEVAGAE 1120
Query: 517 NDQMKQQTRVIKKNAFSPRW-NETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPL 575
D KQ+T + N +P W + F F I PE A +RFVV + + + FL Q T P+
Sbjct: 1121 YDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPV 1180
Query: 576 LCMNKGYRRIPLFSRMGESLEPASLFVYV 604
+ GYR +PL + E LE ASL + +
Sbjct: 1181 KGLKTGYRAVPLKNNYSEDLELASLLIKI 1209
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 174 bits (440), Expect = 3e-43
Identities = 103/313 (32%), Positives = 168/313 (53%), Gaps = 16/313 (5%)
Query: 4 RWFLSKIQ--DDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFR 61
RW + D R +I+ + + +L +++ R + + + + G IT +F
Sbjct: 155 RWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFA 214
Query: 62 AIYRIITHREE------IIEIFNTYSENRKILLASNLAQF------LTQEQYAAEMSKAI 109
+YR + + + +E + R L +L +F E +A + +
Sbjct: 215 QLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQ 274
Query: 110 AFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQD-MTHPLNDYFISS 168
F + +P+ E+ + + L+ F ++ S+E ++ ++ V D M +PL+ Y+ISS
Sbjct: 275 EFMLSFLRDPLREIEEPY-FFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISS 333
Query: 169 SHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTV 228
SHNTYL DQ S L Y L GCRC+E+DCWDG PV+YHG+TLT+K+ F V
Sbjct: 334 SHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDV 393
Query: 229 IQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPE 288
+ I ++AF+ S+YPV+LS+E+HCS AQQ MA + G++LL+ ++ D LPSP
Sbjct: 394 LHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEISADGLPSPN 453
Query: 289 ALKFKILVKNKKI 301
LK KIL+K+KK+
Sbjct: 454 QLKRKILIKHKKL 466
Score = 153 bits (386), Expect = 5e-37
Identities = 95/269 (35%), Positives = 145/269 (53%), Gaps = 9/269 (3%)
Query: 341 RKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARK-LSKLRVHEFIFHT 399
R+ KIAL LS+LV+Y + F + + + +S ET+A K ++K + +F+ +
Sbjct: 945 RRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYN 1004
Query: 400 RKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYIL 459
R ++RIYPK R DSSN++P W G Q+VALNFQTP PM + F+ GY+L
Sbjct: 1005 RLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVL 1064
Query: 460 KPHFLR-ESKSYFNPSNIKEGMPITLTIRLISGIQLPLTHSSSNKG--DSLVIIEVFGVP 516
+P +R E+ F+ S+++ P ++I ++ LP + +G V IEV G
Sbjct: 1065 QPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLP----KNGRGIVCPFVEIEVAGAE 1120
Query: 517 NDQMKQQTRVIKKNAFSPRW-NETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPL 575
D KQ+T + N +P W + F F I PE A +RFVV + + + FL Q T P+
Sbjct: 1121 YDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPV 1180
Query: 576 LCMNKGYRRIPLFSRMGESLEPASLFVYV 604
+ GYR +PL + E LE ASL + +
Sbjct: 1181 KGLKTGYRAVPLKNNYSEDLELASLLIKI 1209
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 172 bits (435), Expect = 1e-42
Identities = 112/341 (32%), Positives = 183/341 (53%), Gaps = 33/341 (9%)
Query: 12 DDFRGGKINLEKTQRLLEKLDIRCSYIH-VKQIFKDNDRLKQGRITIEEFRAIYR--IIT 68
D R I+L + + +L ++ + S +K F + K ++ E+F Y+ +
Sbjct: 154 DQTRRNSISLRELKTILPLINFKVSSAKFLKDKFVEIGAHKD-ELSFEQFHLFYKKLMFE 212
Query: 69 HREEIIEIF----------NTYSENRKILLASNLAQFLTQEQ---YAAEMSKAIAFEIIQ 115
++ I++ F NT + + + +FL EQ +A +++K E +
Sbjct: 213 QQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVR--ERMT 270
Query: 116 KY--EPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKV-YQDMTHPLNDYFISSSHNT 172
K+ + + E + + ++ F Y+ SRE ++ + V QDM +PL+ Y+ISSSHNT
Sbjct: 271 KFIDDTMRETAEPF-LFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNT 329
Query: 173 YLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAI 232
YL DQL S Y+ L GCRC+E+DCWDG +PV+YHG+T T+K+ F V+QAI
Sbjct: 330 YLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAI 389
Query: 233 HKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKF 292
+AF+TS +PV+LS+E HCS QQ MA + FG+ LL+ + D LPSP L+
Sbjct: 390 KDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLRE 449
Query: 293 KILVKNKKIG----------TLKETHERKGSDKRGDNQDKE 323
KI++K+KK+G K+ H+++G D+ D++
Sbjct: 450 KIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSIDQK 490
Score = 148 bits (374), Expect = 1e-35
Identities = 93/263 (35%), Positives = 137/263 (52%), Gaps = 9/263 (3%)
Query: 345 IALALSDLVIYTK-AEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFI 403
IA+ LSDLV+Y K K K + F E S ET+A + + + + + + +K +
Sbjct: 926 IAIELSDLVVYCKPTSKTKDNLEN---PDFREIRSFVETKADSIIRQKPVDLLKYNQKGL 982
Query: 404 TRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHF 463
TR+YPK R DSSN++P W G QMVALNFQT M + + F NG +GY+L+P
Sbjct: 983 TRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPES 1042
Query: 464 LRESKSYFNPSNIKEGMPITLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQ 523
+R K P + + +TLT++++ LP S V +E+ G D K +
Sbjct: 1043 MRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI--ACPFVEVEICGAEYDNNKFK 1100
Query: 524 TRVIKKNAFSPRW---NETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNK 580
T V+ N SP W E TF I+ P LA +RFVV + + + FL T P+ +
Sbjct: 1101 TTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKS 1160
Query: 581 GYRRIPLFSRMGESLEPASLFVY 603
G+R +PL + E +E ASL V+
Sbjct: 1161 GFRSVPLKNGYSEDIELASLLVF 1183
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 41.2 bits (95), Expect = 0.003
Identities = 28/96 (29%), Positives = 52/96 (54%), Gaps = 7/96 (7%)
Query: 483 TLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTF 542
TLT++++ +LP S G S ++++ +P+ + K +T+V +KN +P WNETF F
Sbjct: 151 TLTVKIMKAQELPAKDFS---GTSDPFVKIYLLPDKKHKLETKVKRKN-LNPHWNETFLF 206
Query: 543 IIHVPELALIRFV---VEGQGLIAGNEFLGQYTLPL 575
E + R + V + N+ +G+ ++PL
Sbjct: 207 EGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPL 242
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 40.0 bits (92), Expect = 0.006
Identities = 28/91 (30%), Positives = 47/91 (51%), Gaps = 4/91 (4%)
Query: 486 IRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQ-QTRVIKKNAFSPRWNETFTFII 544
+R+I+GI L D V + ++ N + QT+ IKK+ +P+WNE F +
Sbjct: 23 VRVIAGIGLA-KKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKS-LNPKWNEEILFRV 80
Query: 545 HVPELALIRFVVEGQGLIAGNEFLGQYTLPL 575
H P+ + F V + + ++FLGQ +PL
Sbjct: 81 H-PQQHRLLFEVFDENRLTRDDFLGQVDVPL 110
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 38.9 bits (89), Expect = 0.014
Identities = 27/92 (29%), Positives = 50/92 (54%), Gaps = 6/92 (6%)
Query: 484 LTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFI 543
L +R++ + LP S+ G S ++++ +P+ + K QT+V +K +P +NETF F
Sbjct: 316 LVVRILQALDLPAKDSN---GFSDPYVKIYLLPDRKKKFQTKVHRKT-LNPVFNETFQFS 371
Query: 544 IHVPELA--LIRFVVEGQGLIAGNEFLGQYTL 573
+ + ELA + F V + ++ +GQ L
Sbjct: 372 VPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 38.9 bits (89), Expect = 0.014
Identities = 27/92 (29%), Positives = 50/92 (54%), Gaps = 6/92 (6%)
Query: 484 LTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFI 543
L +R++ + LP S+ G S ++++ +P+ + K QT+V +K +P +NETF F
Sbjct: 316 LVVRILQALDLPAKDSN---GFSDPYVKIYLLPDRKKKFQTKVHRKT-LNPVFNETFQFS 371
Query: 544 IHVPELA--LIRFVVEGQGLIAGNEFLGQYTL 573
+ + ELA + F V + ++ +GQ L
Sbjct: 372 VPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 38.9 bits (89), Expect = 0.014
Identities = 27/92 (29%), Positives = 50/92 (54%), Gaps = 6/92 (6%)
Query: 484 LTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFI 543
L +R++ + LP S+ G S ++++ +P+ + K QT+V +K +P +NETF F
Sbjct: 316 LVVRILQALDLPAKDSN---GFSDPYVKIYLLPDRKKKFQTKVHRKT-LNPVFNETFQFS 371
Query: 544 IHVPELA--LIRFVVEGQGLIAGNEFLGQYTL 573
+ + ELA + F V + ++ +GQ L
Sbjct: 372 VPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 36.6 bits (83), Expect = 0.069
Identities = 25/100 (25%), Positives = 51/100 (51%), Gaps = 6/100 (6%)
Query: 484 LTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFI 543
LT+ ++ +LP G S ++VF +P+ + K +T+V +K +P +NETFTF
Sbjct: 156 LTVGVLQAAELPALDMG---GTSDPYVKVFLLPDKKKKYETKVHRKT-LNPAFNETFTFK 211
Query: 544 IHVPELA--LIRFVVEGQGLIAGNEFLGQYTLPLLCMNKG 581
+ EL + + + ++ +G+ +P+ ++ G
Sbjct: 212 VPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLG 251
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 36.6 bits (83), Expect = 0.069
Identities = 25/100 (25%), Positives = 51/100 (51%), Gaps = 6/100 (6%)
Query: 484 LTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFI 543
LT+ ++ +LP G S ++VF +P+ + K +T+V +K +P +NETFTF
Sbjct: 156 LTVGVLQAAELPALDMG---GTSDPYVKVFLLPDKKKKYETKVHRKT-LNPAFNETFTFK 211
Query: 544 IHVPELA--LIRFVVEGQGLIAGNEFLGQYTLPLLCMNKG 581
+ EL + + + ++ +G+ +P+ ++ G
Sbjct: 212 VPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLG 251
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,657,861
Number of Sequences: 37866
Number of extensions: 947830
Number of successful extensions: 2458
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 2292
Number of HSP's gapped (non-prelim): 163
length of query: 608
length of database: 18,247,518
effective HSP length: 108
effective length of query: 500
effective length of database: 14,157,990
effective search space: 7078995000
effective search space used: 7078995000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.